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2025

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The Potential For Diagnosing High Blood Pressure At The Dentist: An Examination Of Periodontal Disease And The Oral Microbiome In Raised Blood Pressure., Amazon Doble Jan 2025

The Potential For Diagnosing High Blood Pressure At The Dentist: An Examination Of Periodontal Disease And The Oral Microbiome In Raised Blood Pressure., Amazon Doble

Peninsula Dental School Theses

Background: Hypertension is increasingly linked to periodontitis. However, the nature and specific mechanistic relationship of this remains unclear, however may involve reduced oral and systemic nitric oxide (NO) availability. There remains limited research on the oral microbiome during hypertension that could support such a causative mechanism involving NO.Aims: This project aimed to examine links between periodontal disease, the oral microbiome, and raised blood pressure, while establishing a cardiovascular risk case-finding clinic with a GP referral pathway.Methods: The project comprised three studies: Study I established and identified cardiovascular risk case-finding in a dental environment (n=200). Study II evaluated clinical markers and …


From Recognition To Action: Surf-Driven Governance In The Manly And Freshwater World Surfing Reserve, Kizzy Beaumont, Joao Castro Jan 2025

From Recognition To Action: Surf-Driven Governance In The Manly And Freshwater World Surfing Reserve, Kizzy Beaumont, Joao Castro

School of Art, Design and Architecture

Executive summary This report presents findings from a focus group with members of the Manly and Freshwater World Surfing Reserve (WSR) Local Stewardship Council. Participants reflected on changes over the past decade and imagined future pathways for the WSR. Discussions revealed a strong sense of community pride and renewed momentum following the WSR’s relaunch, which has reconnected previously fragmented grassroots efforts.Key challenges identified included surf crowding, political inertia, water pollution, and a lack of formal governance mechanisms. While engagement with the local Council has improved, participants stressed the need for more consistent follow-through, youth inclusion, and funding security. Concerns were …


The Gut-Brain Axis: Investigating The Effects Of Diet, Physical Activity, And Prior Adversity On Anxiety Via Autonomic Nervous System, Jenna L. Pennella Jan 2025

The Gut-Brain Axis: Investigating The Effects Of Diet, Physical Activity, And Prior Adversity On Anxiety Via Autonomic Nervous System, Jenna L. Pennella

UNF Graduate Theses and Dissertations

Previous literature has highlighted a bidirectional relationship between the gut and brain called the gut-brain axis (de Punder & Pruimboom, 2015; Hill et al., 2008; Leistner & Menke, 2020). The current study aimed to investigate directional relations between different stressors (e.g. poor diet, vigorous activity, and prior adversity) and anxiety and how interactions with gut issues and autonomic dysfunction may impact these relationships. Based on previous literature, we examined (a) physical activity and diet as moderators of stress and anxiety as well as stress and GI symptoms, (b) GI symptoms as a mediator between various predictors (i.e., diet, stress, physical …


Urban Heat Island Effects On Arthropod Populations And Communities In Jacksonville, Fl, Eleanor G. Cronin Jan 2025

Urban Heat Island Effects On Arthropod Populations And Communities In Jacksonville, Fl, Eleanor G. Cronin

UNF Graduate Theses and Dissertations

The urban heat island (UHI) effect makes urban areas hotter than rural areas. Urban areas, and the extreme heat that comes with them, are becoming more common worldwide. If UHIs lead to changes in arthropod community diversity, then ecosystem structure and services could be disrupted. Previous UHI studies have investigated heat impacts on arthropod ecology, but many focus on one species while studies that consider thermal diversity within a single urban area have been limited. In Jacksonville, Florida, areas that are 12°C hotter than the coolest areas are considered local UHIs. The goal of this research is to investigate how …


Use Of Coelomic Fluid As A Noninvasive Indicator Of Reproductive Status In Elasmobranchs, Emily Sapp Jan 2025

Use Of Coelomic Fluid As A Noninvasive Indicator Of Reproductive Status In Elasmobranchs, Emily Sapp

UNF Graduate Theses and Dissertations

Information on reproduction in elasmobranchs is important for the management and conservation of populations. However, the ability to obtain reliable data on elasmobranch reproduction without animal euthanasia is extremely limited. Therefore, there has been a call for nonlethal approaches for identifying reproductive status of elasmobranchs. Although useful, current techniques can be limited with respect to access to equipment and reliability of blood analyses. This study investigates whether a new noninvasive approach, the examination of coelomic fluid (CF), can provide a reliable indicator of reproductive status. CF is fluid that bathes the internal organs of the abdominal cavity, including ovaries, and …


Dynamics Of Prey-Prey Mutualism With Varying Carrying Capacity And Herd Behavior In The Presence Of Predator, Felix Dela Djokoto Jan 2025

Dynamics Of Prey-Prey Mutualism With Varying Carrying Capacity And Herd Behavior In The Presence Of Predator, Felix Dela Djokoto

UNF Graduate Theses and Dissertations

This study investigates the dynamics of mutualistic relationships between two prey species in the presence of a predator, by taking into account herding in one species along with the influence of carrying capacities between two prey species. These mutualistic dynamics are presented by constructing two mathematical models, namely an indirect and direct mutualism model. As the strength of the symbiotic relationship increases the indirect model goes through transcritical bifurcation to Hopf bifurcation whereas in the direct mutualism model goes through saddle-node bifurcation to Hopf bifurcation.


Diversity Makes Me Uncomfortable: Effects Of Diversity Language On University Student Belonging, Ziena Baker Jan 2025

Diversity Makes Me Uncomfortable: Effects Of Diversity Language On University Student Belonging, Ziena Baker

UNF Graduate Theses and Dissertations

Diversity statements and experiences form the first impressions students have of their prospective universities and employers, setting the stage for perceived feelings of belonging, otherness, and comfort within new environments (Baleria, 2021; O’Keeffe, 2013; Starck et al., 2021). Diversity statements can signal feelings of comfort and belonging or feelings of stress depending on the way in which diversity is framed (Chaney, 2022; Trawalter et al., 2016). This is especially true for students, who are more often affected mentally and physically by changes in university diversity perspectives (Sladek et al., 2021) The current study thus uses a novel blood pressure measure …


The Stochastic Occupation Kernel (Sock) Method For Learning Stochastic Differential Equations, M. L. Wells, Kamel Lahouel, Bruno Jedynak Jan 2025

The Stochastic Occupation Kernel (Sock) Method For Learning Stochastic Differential Equations, M. L. Wells, Kamel Lahouel, Bruno Jedynak

Mathematics and Statistics Faculty Publications and Presentations

We present a novel kernel-based method for learning multivariate stochastic differential equations (SDEs). The method follows a two-step procedure: we first estimate the drift term function, then the (matrix-valued) diffusion function given the drift. Occupation kernels are integral functionals on a reproducing kernel Hilbert space (RKHS) that aggregate information over a trajectory. Our approach leverages vector-valued occupation kernels for estimating the drift component of the stochastic process. For diffusion estimation, we extend this framework by introducing operator-valued occupation kernels, enabling the estimation of an auxiliary matrix-valued function as a positive semi-definite operator, from which we readily derive the diffusion estimate. …


The Impact Of Socioeconomic Status On Substance Use Amongst The Hispanic Maternal Population, Emily C. Olivo Jan 2025

The Impact Of Socioeconomic Status On Substance Use Amongst The Hispanic Maternal Population, Emily C. Olivo

Honors Undergraduate Theses

Aim: To explore and synthesize existing research that focuses on the relationship between socioeconomic status and the use of substances amongst the maternal Hispanic population. By examining research and these factors, interventions can be identified to lower reported substance use rates amongst Hispanic mothers of childbearing ages.

Background: Minorities such as Hispanic women deal with a myriad of struggles, especially during motherhood. Socioeconomic status and substance use can contribute to a large part of the struggles faced by this population. Hispanic and Latina will be used interchangeably throughout this review of literature.

Method: A comprehensive electronic review of 3 databases …


Organization And Activation Of Caffeine Expectancies, Catherine S. Forsyth Jan 2025

Organization And Activation Of Caffeine Expectancies, Catherine S. Forsyth

Honors Undergraduate Theses

Caffeine is the most consumed and widely used psychoactive substance in the world. Whether someone uses caffeine or not, expectations about use can be influential to some degree. Expectancies exist everywhere and are extremely influential in all aspects of life. Regarding drug use, expectancies can affect behavior, outcomes, and one’s experience with the drug. Caffeine is no exception, caffeine expectancies have been seen to play a role in several actions such as the development, maintenance, and reinforcement of caffeine use. This study examined latent use profiles of caffeine and relationships between the profiles and the activation of caffeine expectancies. Multidimensional …


Assessing The Relationship Between Perceived Psychological And Physical Pain In Adults With Orthopedic Pain, Daniel C. Karimi Dehkordi Jan 2025

Assessing The Relationship Between Perceived Psychological And Physical Pain In Adults With Orthopedic Pain, Daniel C. Karimi Dehkordi

Honors Undergraduate Theses

Suicide remains a public health concern in the U.S., particularly among individuals experiencing chronic pain and psychological distress. This cross-sectional study investigated the relationship between perceived physical and psychological pain in 41 adults with chronic orthopedic conditions. The relationship between other risk and protective factors and perceived levels of pain distress was also examined. Results showed a significant positive correlation between psychological distress and physical pain (r(39) = 0.388, p < .05) and psychological distress and depressive/anxiety symptoms (r (39) = 0.477, p < .01). Psychological distress was moderately associated with feelings of hopelessness (r (39) = 0.403, p < .01), however, the relationship between physical pain and hopelessness was weak and nonsignificant (r (39) = -0.06, p = .71). Contrary to expectations, emotional support did not buffer the effects of psychological distress (r (39) = 0.07, p = 0.66). Mediational analysis confirmed that emotional support did not influence the relationship between physical pain and psychological distress (Beta (β) = -0.969, p = 0.572; Sobel Z = 0.5598, p = 0.575). Age was not correlated with psychological distress (r (39) = -0.24, p = 0.13) or mental health symptoms (r (39) = -0.05, p = .77). While there was no significant difference across sex, males reported higher mental health symptomatology and psychological distress scores than female counterparts. These findings underscore the direct impact of physical pain on psychological distress and challenge assumptions about the protective role of social support. The study highlights the need for integrated, multidisciplinary interventions targeting both physical and psychological pain to mitigate suicide risk among individuals with chronic orthopedic conditions. Future research should iii explore alternative support mechanisms and resilience-building strategies to address the complex interplay of pain, distress, and suicidality.


Intelligent Tutoring Systems In The Age Of Llm-Based Agentic Frameworks - Adapting Small On-Device Language Models For Fact-Checking And Student Compliance Detection, Evan Vahid Naderi Jan 2025

Intelligent Tutoring Systems In The Age Of Llm-Based Agentic Frameworks - Adapting Small On-Device Language Models For Fact-Checking And Student Compliance Detection, Evan Vahid Naderi

Honors Undergraduate Theses

As large language models (LLMs) demonstrate increasingly sophisticated language understanding capabilities, they offer transformative potential for educational technology, particularly in developing more responsive intelligent tutoring systems (ITS). To develop these systems, a synthesis that balances theoretical frameworks with practical, cutting-edge, and deployable technology would be useful. This thesis aims to advance the field of ITSs theoretically by viewing the modern advancements in natural language processing within the context of the foundational frameworks important to the fields of self-regulated learning, ITSs, and cognitive agents. Then, building on prior research on the ITS MetaTutor \citep{Azevedo2022}, this research focuses on how functions of …


Physical Activity And Hypertension Outcomes Around Menopause In Adult Women—A Secondary Analysis Of The All Of Us Research Program, Meriam F. Naguib Jan 2025

Physical Activity And Hypertension Outcomes Around Menopause In Adult Women—A Secondary Analysis Of The All Of Us Research Program, Meriam F. Naguib

Honors Undergraduate Theses

Hypertension significantly impacts menopausal women due to a decrease in estrogen levels. That is due to estrogen level changes, causing many metabolic alterations, one of which is increased vascular resistance, leading to hypertension. Advanced treatments are made available to help alleviate the condition; however, lifestyle modifications—especially physical activity—show a critical role in hypertension control. This thesis explored the effect of physical activity as a non-pharmacological, lifestyle intervention on hypertension in women by menopausal status (pre-, peri-, and post-menopausal). This study used a secondary analysis with a retrospective design. Physical activity was defined using the American Heart Association's (AHA) guidelines (i.e., …


The Stigmatization Of Autism – Why It’S Still Present And How It Affects Women And Individuals Assigned Female At Birth (Afab), Emma Drauer Jan 2025

The Stigmatization Of Autism – Why It’S Still Present And How It Affects Women And Individuals Assigned Female At Birth (Afab), Emma Drauer

Honors Undergraduate Theses

The intent of this thesis is to explain some key factors (the theory of mind notion and the narrow perception of autism) that contribute to the stigmatization of autism and the impact this has on autistic women. Autistic women are heavily underrepresented, especially in the scholarly discourse, so this thesis collected first person accounts of autistic experiences through a survey and interviews. This data revealed important information such as the benefits of a diagnosis, how stigma can prevent this and have consequences, and the struggles autistic women face. Unmasking these struggles can help make the general public aware of their …


The Intersection Of Autism Spectrum Disorder And Mental Health: A Focus On College Students, Sudeepta Matha Jan 2025

The Intersection Of Autism Spectrum Disorder And Mental Health: A Focus On College Students, Sudeepta Matha

Honors Undergraduate Theses

Rising prevalence rates of autism spectrum disorder (ASD), changes in diagnostic criteria, and increased public awareness have all contributed to the growing population of college students with ASD. However, many individuals - commonly referred to as the “lost generation” - go undiagnosed, due to experiencing negative interactions with mental health professionals. As a result, these individuals are not given the proper support and interventions required for a successful transition into adulthood, and often face heightened social isolation, academic problems, mental health challenges compared to their neurotypical peers. A combination of these factors can lead to increased suicidal ideation (SI) and …


Anxiety And Adaptive Functioning In Young Adults: The Moderating Role Of Psychological Flexibility, Makenzie L. Kennedy, Jeffrey E. Cassisi Jan 2025

Anxiety And Adaptive Functioning In Young Adults: The Moderating Role Of Psychological Flexibility, Makenzie L. Kennedy, Jeffrey E. Cassisi

Honors Undergraduate Theses

Anxiety is highly prevalent among emerging adults and is associated with impairments in academic, social, and daily functioning. While previous research has documented strong associations between anxiety and adaptive functioning, the present study uniquely tested psychological flexibility as a potential moderator that may foster resilience and adaptive coping.

Undergraduate students (N = 522) from the University of Central Florida completed measures of anxiety (PROMIS-A, GAD-7, STAI-S), adaptive functioning (WHODAS 2.0), and psychological flexibility (COMPACT-23). Confirmatory factor analyses supported distinct but correlated latent constructs of anxiety and adaptive functioning. Due to poor subscale intercorrelations, the COMPACT-23 total score was modeled as …


Generation Z’S Perception Of Skin Cancer And How It Relates To Climate Change, Piercen Bogolea Jan 2025

Generation Z’S Perception Of Skin Cancer And How It Relates To Climate Change, Piercen Bogolea

Honors Undergraduate Theses

Skin cancer is the most common cancer worldwide, and climate change has been identified as a significant contributor. Preventative action early on can help reduce occurrence, but it is unknown if Generation Z is aware of this and is taking the necessary action now to protect themselves. This research aims to gauge the perception of Generation Z on the severity of skin cancer, the relationship between climate change and skin cancer, and the prevalence of preventative measures being taken. A survey was distributed to students aged 18 to 27 enrolled at the University of Central Florida through mixed sampling. The …


Genomic Epidemiology Of Staphylococcus Aureus Sequence-Type 97, Eva Armao Jan 2025

Genomic Epidemiology Of Staphylococcus Aureus Sequence-Type 97, Eva Armao

Honors Undergraduate Theses

Staphylococcus aureus (S. aureus) is a gram-positive bacterial pathogen that colonizes human nasal passages, mucous membranes, or the skin of carriers, with colonization commonly found in 20-30% of healthy people. S. aureus has the potential for two types of infection within human hosts: methicillin-susceptible (MSSA) and methicillin-resistant (MRSA). These infections can be further classified based on their route of infection, either known as community-associated (CA), healthcare-associated (HA), or healthcare-associated community-onset (HACO). Upon further investigation of infected populations, specific genetic subtypes of S. aureus, known as sequence types (ST), have been identified globally, with some exhibiting increased virulence among …


Uv- Altered Macrophages: Impact Of Uv Radiation On Phagocytic Receptor Expression In M2 Macrophages And Implications For Tissue Repair And Immunosuppression, Hala Hafez Jan 2025

Uv- Altered Macrophages: Impact Of Uv Radiation On Phagocytic Receptor Expression In M2 Macrophages And Implications For Tissue Repair And Immunosuppression, Hala Hafez

Honors Undergraduate Theses

Ultraviolet radiation is an environmental stressor known to suppress immune function in the skin, but its effect on the immunoregulatory M2 phenotype macrophages is poorly studied. This study aims to investigate the impact of UV exposure on key markers of the M2 macrophage, which are critical for tissue repair and immunosuppression. THP-1 monocytes were differentiated and polarized into the M2 phenotype using Phorbol-12 myristate (PMA) and Cytokines IL-4 and IL-10. Once differentiation was confirmed, the macrophages were exposed to varying durations of UV radiation. Real Time Quantitative PCR was used to analyze expression changes in phagocytic receptors (CD206, CD163, Arg-1), …


Exploring Biostimulant Efficacy Under Limited Fertilizer And Water In Utah's Watermelon Production, Evan Christensen, Milena Oliveira, Prakriti Nepal, Youping Sun Jan 2025

Exploring Biostimulant Efficacy Under Limited Fertilizer And Water In Utah's Watermelon Production, Evan Christensen, Milena Oliveira, Prakriti Nepal, Youping Sun

Plants, Soils and Climate Student Research

The western U.S. has recently experienced some of the driest conditions on record, and Utah has been in a multi-year drought (2019-2023) that affected the agricultural sector, including vegetable producers. While vegetables are not a primary agricultural crop in Utah, they are still an important part of the horticultural economy with 763 farms growing 6,138 acres. As the fourth largest acreage vegetable crop in Utah (almost 10% of the acreage) watermelon and related crops in the gourd family Cucurbitaceae (nearly 36% of total vegetable acreage) are important to vegetable growers. Watermelon is a water-intensive crop and requires an adequate supply …


Biomarkers In Coronary Artery Disease: Systematic Review And Meta-Analysis, Nicola King, Neil A. Smart, Theodore Bungon, Martin Peacock, Shakil A. Awan Jan 2025

Biomarkers In Coronary Artery Disease: Systematic Review And Meta-Analysis, Nicola King, Neil A. Smart, Theodore Bungon, Martin Peacock, Shakil A. Awan

Faculty of Science and Engineering Datasets

Little information exists regarding the detection of early coronary heart disease protein biomarkers. The aim of this study was to investigate several potential candidates. Systematic review was carried out followed by meta-analysis. The standardized mean difference (95% confidence intervals) for each comparison was: Troponins 2.31 (1.18, 3.4), iL-6 1.3 (0.8, 1.81), fibrinogen 1.55 (1.16, 1.94), NT-proBNP 1.05 (0.72, 1.38), lipoprotein a 0.75 (0.48, 1.03) osteoprotegerin 0.92 (0.23, 1.62), VCAM-1 1.53 (0.87, 2.18), pentraxin 3 0.87 (−0.13, 1.87), PAI-1 2.51 (−0.65, 5.66) MMP9 1.25 (0.36, 2.14), MCP-1 1.99 (1.12, 2.85) and adiponectin −1.11 (−1.49, −0.73). Multiple biomarkers that could potentially be …


Whose Burden Is It Anyway? A Comprehensive Proposal To Reshape Food Safety Review By Treating Food As Medicine, Katya S. Cronin Jan 2025

Whose Burden Is It Anyway? A Comprehensive Proposal To Reshape Food Safety Review By Treating Food As Medicine, Katya S. Cronin

GW Law Faculty Publications & Other Works

With more than sixty percent of U.S. adults struggling with at least one diet-related health condition, the relationship between nutrition and public health has never been clearer. Indeed, for the first time in over a century, food has a prominent place on the national political stage and is one of the exceedingly few issues that has garnered bipartisan support. The recent rise in popularity of "Food Is Medicine" initiatives, which seek to provide medically tailored or healthy meals to vulnerable populations, underscores the critical importance of food to public health. Yet, while "Food Is Medicine" is shifting the insurance, business, …


Foster Care Students And Their Success In Academic Achievements In School, Kirsten Nassiff Jan 2025

Foster Care Students And Their Success In Academic Achievements In School, Kirsten Nassiff

Theses and Dissertations

This applied dissertation was designed to provide better training and resources for teachers working with students in foster care who have experienced multiple foster care placements, and to assist them in achieving academic success.

The researcher conducted semi-structured interviews with six educators and staff at an alternative school that has the highest number of students in foster care, located in this school district. Using Braun and Clarke’s six steps for Thematic Analysis, each transcript was coded with the assistance of MAXQDA, and themes were developed.

An analysis of the data revealed that educators and staff do not receive adequate communication …


Analysis Of Mapt On Alzheimer’S Disease, Elaine Vanterpool, Marc Morgan Jr. Jan 2025

Analysis Of Mapt On Alzheimer’S Disease, Elaine Vanterpool, Marc Morgan Jr.

Student Posters

Alzheimer’s is the 7 th most common cause for death in humans and unfortunately has no cure. Coincidentally the gene MAPT (microtubule-associated protein tau) increases chances of obtaining Alzheimer's. The purpose of this study is to discover the mutation that resides within this gene. A website database called Simple Clinvar was used to generate information concerning Alzheimer’s disease and the different genetic variants associated with the disease. The SIFT algorithm was used to show whether the changes in amino acid sequences of the MAPT gene can affect protein function. PolyPhen was another prediction algorithm used to predict the influence that …


How Latine College Students Experience, Maneuver, And Navigate Within The Colonizing Notion Of Smartness, Jasmine Jetton-Gonzales Jan 2025

How Latine College Students Experience, Maneuver, And Navigate Within The Colonizing Notion Of Smartness, Jasmine Jetton-Gonzales

Theses and Dissertations

This study explores how Latine college students, particularly those who are the first in their family to attend college, navigate and maneuver within the dominating colonizing notion of smartness in academia. Rooted in an Anglo-centric educational framework, the American education system often marginalizes Latine students by devaluing their cultural and linguistic knowledge while upholding Eurocentric standards of intelligence. Using a qualitative critical research approach, this study employs testimonios to examine the lived experiences of Latine college graduates in Illinois. Findings reveal that Latine students frequently encounter systemic barriers that challenge their academic identity, including racialized perceptions of intelligence, institutionalized deficit …


Stress And Behavior In Beef Calves During Weaning, Kathleen E. Tierney Jan 2025

Stress And Behavior In Beef Calves During Weaning, Kathleen E. Tierney

Theses and Dissertations

Animal welfare in commercial livestock operations has been an increasing topic of concern. It is well known that stress can have significant behavioral and physiological repercussions. It is especially important in commercial operations to reduce stress, as animal efficiency is the leading priority. In an effort to reduce stress on animals and improve welfare in livestock operations, several studies have evaluated common husbandry practices. One of the most widely studied practices is weaning, which encapsulates the process of removing the young from the dam. Several studies have evaluated the effects of weaning on beef cattle through a variety of behavioral …


The Impact Of Perfumes And Cosmetic Products On Human Health: A Narrative Review, Sharifa Alblooshi Jan 2025

The Impact Of Perfumes And Cosmetic Products On Human Health: A Narrative Review, Sharifa Alblooshi

All Works

Background: The use of perfumes and cosmetic products is widespread, serving personal hygiene, aesthetic, and olfactory functions. However, concerns have been raised regarding the potential health impacts associated with long-term exposure to various ingredients used in these products. Objectives: This narrative review aims to synthesize evidence on the health risks associated with perfumes and cosmetics, focusing on specific health concerns, including fertility, respiratory health, cancer risk, allergies, skin disorders, endocrine disruption, and neurological effects. It also discusses the presence of heavy metals in cosmetics, regulatory challenges, and the need for transparency in ingredient disclosure. Methods: A comprehensive review of the …


Fabrication Of Palladium Decorated Zinc Oxide Nanostructures For Non-Enzymatic Glucose Sensing, Reagan Aviha, Anju Joshi, Gymama Slaughter Jan 2025

Fabrication Of Palladium Decorated Zinc Oxide Nanostructures For Non-Enzymatic Glucose Sensing, Reagan Aviha, Anju Joshi, Gymama Slaughter

Center for Bioelectronics Publications

The growing global burden of diabetes necessitates the development of glucose sensors that are not only reliable and sensitive but also cost-effective and amenable to point-of-care use. In this work, we report a non-enzymatic electrochemical glucose sensor based on laser-induced graphene (LIG), functionalized with zinc oxide (ZnO) and palladium (Pd) nanostructures. The ZnO nanostructures were systematically optimized on the LIG surface by varying electrochemical deposition parameters, including applied potential, temperature, and deposition time, to enhance the electrocatalytic oxidation of glucose in alkaline medium. Subsequent modification with Pd nanostructures further improved the electrocatalytic activity and sensitivity of the sensor. The performance …


Advanced Nanocomposite-Based Electrochemical Sensor For Ultra-Sensitive Dopamine Detection In Physiological Fluids, Megha Shinde, Gymama Slaughter Jan 2025

Advanced Nanocomposite-Based Electrochemical Sensor For Ultra-Sensitive Dopamine Detection In Physiological Fluids, Megha Shinde, Gymama Slaughter

Center for Bioelectronics Publications

This study presents a novel point-of-care electrochemical sensor for dopamine (DA) detection, featuring a flexible laser-induced graphene (LIG) modified with a unique nanocomposite comprising Nb4C3Tx MXene, polypyrrole (PPy), and iron nanoparticles (FeNPs). The LIG-Nb4C3Tx MXene-PPy-FeNPs is characterized by scanning electron microscopy to confirm the successful surface modification. The electrochemical performance of the fabricated sensor via cyclic voltammetry showed significant electrochemical activity upon Nb4C3Tx MXene-PPy-FeNPs nanocomposite modification of the LIG surface with an increased peak anodic current (Ipa) from 43 μA to 104 μA. The sensor …


Electrochemical Strategies For Microrna Quantification Leveraging Amplification And Nanomaterials: A Review, Alexander Hunt, Gymama Slaughter Jan 2025

Electrochemical Strategies For Microrna Quantification Leveraging Amplification And Nanomaterials: A Review, Alexander Hunt, Gymama Slaughter

Center for Bioelectronics Publications

MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression and have emerged as critical biomarkers in various diseases, including cancer. Their stability in bodily fluids and role as oncogenes or tumor suppressors make them attractive targets for non-invasive diagnostics. However, conventional detection methods, such as Northern blotting, RT-PCR, and microarrays, are limited by low sensitivity, lengthy protocols, and limited specificity. Electrochemical biosensors offer a promising alternative, providing high sensitivity, rapid response times, portability, and cost-effectiveness. These biosensors translate miRNA hybridization events into quantifiable electrochemical signals, often leveraging redox-active labels, mediators, or intercalators. Recent advancements in nanomaterials and signal amplification …