Digital Commons Network^™

Exploring The State Of Homelessness In Franklin And Licking County, Justice Ofosuhene Jr.

Student Scholarship

No abstract provided.

Preliminary Investigation Of Obstructive Sleep Apnea And Alzheimer's Disease In Down Syndrome, Dasoo M Yoon, David T Plante, Victoria Fleming, Benjamin Handen, Patrick Lao, Jamie Peven, Bradley Christian, Ozioma Okonkwo, Charles Laymon, Beau Ances, Christy Hom, Brian Helsel, Sigan L Hartley

2020-Current year OA Pubs

This study provided a preliminary examination of indices of obstructive sleep apsnea (OSA) and sleep disruptions in adults with Down syndrome (DS), and their associations with Alzheimer's disease (AD) pathology and symptomatology. A total of 93 adults with DS (aged 25-61 years) from the Alzheimer Biomarker Consortium-DS completed cognitive assessments, MRI and positron emission tomography (PET) scans (assessing amyloid-beta [Aβ] and tau), and a one-night home sleep study using the WatchPAT-300 device. Study partners also reported on depressive symptoms and diagnoses. Correlational analyses examined relationships between sleep variables, PET biomarkers, and AD symptomatology (cognitive functioning and depressive mood), controlling for …

Tourette Syndrome Research Highlights From 2024 [Version 3; Peer Review: 2 Approved, 1 Approved With Reservations], Andreas Hartmann, Per Andrén, Cyril Atkinson-Clement, Virginie Czernecki, Cécile Delorme, Simon Morand-Beaulieu, Nanette Mol Debes, Kirsten Müller-Vahl, Peristera Paschou, Natalia Szejko, Apostolia Topaloudi, Kevin J Black

2020-Current year OA Pubs

We summarize research reports from 2024 relevant to Tourette syndrome, which the authors consider the most important or interesting. This working draft aims to submit this content for publication around the beginning of 2025 in the yearly Tourette Syndrome Research Highlights series on F1000Research. The authors welcome article suggestions and thoughtful feedback from readers, who can add a comment by clicking on the rectangular comment box icon to the left of the LOG IN link at the top of this page. For private comments, you can reach us by email ( [email protected] or [email protected]).

Psychophysiological Responses To An Objectified Environment In College-Aged Females, Urska Dobersek, Richard A. Bennett, Sarah E. Siebers, Laurel A. Standiford Reyes

Midwest Social Sciences Journal

Objectification and its associated negative psychological consequences of self-objectification are well-established. Specifically, internalization of an observer’s perspective can lead to habitual body monitoring, negative psychological consequences, and mental health risks. Nevertheless, comparatively few studies examined physiological responses to an objectified environment. To remedy this gap, we explored the effects of an objectified environment on stress levels assessed via salivary cortisol in a single-blind experimental study of 34 undergraduate female students (M_age = 18.62, SD = 0.74). State self-objectification was manipulated by participants wearing tight, revealing exercise clothing (experimental condition; n =16) or baggy exercise attire (control condition; …

Maternal Incarceration, Adolescent Delinquency, And Siblings, Tracey L. Woodard

Midwest Social Sciences Journal

Researchers have estimated that approximately 2.7 million children in the United States have a parent in jail or prison. Since 1991, the number of children with a father in prison grew by 77%, while the number of children with a mother in prison more than doubled (131%). In examining the consequences of maternal incarceration on children, many researchers have found an association between negative child outcomes and maternal incarceration. However, not all research has produced the same conclusions, thus yielding heterogeneous findings. It is essential to understand the factors that may explain the variation in outcomes of children experiencing maternal …

“Finally Girls Hitting A Celly:” Emotions And Gender Embodiment In Competitive Swimmers’ Post-Race Celebrations, Lauren Q. Rohde , '25

Senior Theses, Projects, and Awards

In athletic competitions, the moment of achievement is often extremely cathartic and results in a visible celebration. In competitive swimming, these reactions to success are isolated to the end of a race, completely individual, and often feature interaction with one’s surroundings, such as the water or lane lines. These moments are also highly visible and usually well-photographed, and the visibility of these actions contributes to a growing culture in the sport around post-race celebrations. The exposure of the body in competitive swimming additionally contributes to its visibility, further complicating behaviors and norms around celebrating race outcomes. This research aims to …

Concomitant Traumatic Brain Injury Exacerbates Endotheliopathy In Patients With Spinal Cord Injury, Shahab Hafezi, Miguel A. Ruiz-Cardozo, Sarbani Ghosh, Sravanthi Bandla, Matthew N. Montoya Rush, Anand Dharmarajan, Mark H. Hoofnagle, Isaiah R. Turnbull, Camilo A. Molina, Grace M. Niziolek

2020-Current year OA Pubs

No abstract provided.

Chronic Administration Of A Cannabis-Derived Mixture At An Antihyperalgesic Dose Does Not Significantly Enhance Hepatotoxicity Or The Development Of Metabolic Dysfunction-Associated Steatohepatitis In Male Mice, Kim B. Pedersen, Tomislav Jelesijevic, Tamara M. Morris, Sarah M. Melton, Ashley S. Henderson, John F. Glenn, Gregory J. Davenport, Martin J.J. Ronis, Peter J. Winsauer

School of Medicine Faculty Publications

Cannabis and cannabinoid mixtures have been linked to a variety of health benefits including pain mitigation, suppression of nausea produced by chemotherapeutic agents, anti-inflammatory effects, and effects on energy homeostasis, glucose, and lipid metabolism. The latter properties have led to the suggestion that these products could have therapeutic effects on the development of metabolic dysfunction-associated steatohepatitis (MASH) - a severe type of liver pathology in obese and diabetic patients. However, varying agonist and antagonistic properties of different cannabinoids on the endogenous cannabinoid system make prediction regarding hepatic effects and diet interactions difficult. The current study was designed to examine hepatic …

Dance Improvisation And Kinematics: Describing Spontaneous Motion Among Movers, Fallon Simone Doshi Brackley

Student Scholarship

No abstract provided.

Proteomic Characterization And Comparison Of The Infective And Adult Life Stage Secretomes From Necator Americanus And Ancylostoma Ceylanicum, Yide Wong, Bruce A. Rosa, Makedonka Mitreva, Et Al.

2020-Current year OA Pubs

More than 470 million people globally are infected with the hookworms Ancylostoma ceylanicum and Necator americanus, resulting in an annual loss of 2.1 to 4 million disability-adjusted-life-years. Current infection management approaches are limited by modest drug efficacy, the costs associated with frequent mass drug administration campaigns, and the risk of reinfection and burgeoning drug resistance. Subunit vaccines based on proteins excreted and secreted (ES) by hookworms that reduce worm numbers and associated disease burden are a promising management strategy to overcome these limitations. However, studies on the ES proteomes of hookworms have mainly described proteins from the adult life stage …

Scoping Review Of Machine Learning Techniques In Marker-Based Clinical Gait Analysis, Kevin N. Dibbern, Maddalena G. Krzak, Alejandro Olivas, Mark V. Albert, Joseph J. Krzak, Karen M. Kruger

Biomedical Engineering Faculty Research and Publications

The recent proliferation of novel machine learning techniques in quantitative marker-based 3D gait analysis (3DGA) has shown promise for improving interpretations of clinical gait analysis. The objective of this study was to characterize the state of the literature on using machine learning in the analysis of marker-based 3D gait analysis to provide clinical insights that may be used to improve clinical analysis and care. Methods: A scoping review of the literature was conducted using the PubMed and Web of Science databases. Search terms from eight relevant articles were identified by the authors and added to by experts in clinical gait …

Advancing The Environmental Dna And Rna Toolkit For Aquatic Ecosystem Monitoring And Management, Xavier Pochon, Holly A. Bowers, Anastasija Zaiko, Susanna A. Wood

Faculty Research, Scholarly, and Creative Activity

The application of environmental DNA (eDNA) and RNA (eRNA) technologies to aquatic ecosystem monitoring and management has increased rapidly in the last decade. These methods are providing many new and exciting opportunities for enhanced biodiversity assessment, ecological health evaluation, and species detection. This special issue of PeerJ Life and Environment brings together 20 innovative studies that collectively advance the eDNA toolkit. Four key themes are covered: (i) Methodological advancements, (ii) Ecological health assessments and biomonitoring, (iii) Species detection, and (iv) Application and management. The studies cover a suite of topics including; optimizing sample collection, developing species-specific assays, evaluating bioindicator species, …

Does Mean Arterial Pressure Augmentation Improve Neurological Recovery Of Blunt Spinal Cord Injuries: An East Multicenter Trial., Aimee Lariccia, Stephanie Doris, Bhairav Shah, Tanisha Kashikar, Erik Teicher, Lindsey Perea, Jennifer Huber, Malia Eischen, H Akin Erol, Michael Steven Farrell, Lauren Colom, Stephanie Scott, Brian Daley, James Bardes, Gregory Schaefer, Melissa Moncrief, William Devoe, Ryan Peter Dumas, Caitlin Anne Fitzgerald, William Brigode, John D Berne, Dalier R Mederos, Scott Armen, Melissa Linskey Dougherty, Asanthi Ratnasekera, Emily Alberto, Alison Smith, Bradley M Dennis, Stephen Gadomski, Jeffry Nahmias, Claudia Alvarez, Salina Wydo, Jennifer Schweinsburg, Carlos H Palacio, M Chance Spalding, Joshua Hill

Trauma and Acute Care Articles

BACKGROUND: Treatment of blunt traumatic spinal cord injuries (SCIs) often includes maintaining elevated mean arterial blood pressures (MAP) to enhance perfusion to the spinal cord. Optimal hyperperfusion protocols and treatment algorithms have yet to be delineated due to a paucity of large volume prospective studies. This study aims to identify predictors of neurological improvement in American Spinal Injury Association (ASIA) impairment score following blunt SCI.

STUDY DESIGN: Prospective (January 10, 2021 to June 1, 2023) multicenter study included blunt SCI patients age >18 with complete neurological examination documented on hospital arrival. Patients were divided into two groups: neurological improvement and …

Reinforcement Learning Methods For Assistive And Rehabilitation Robotic Systems: A Survey, Mojtaba Sharifi, Shreesh Tripathi, Yun Chen, Qiang Zhang, Mahdi Tavakoli

Faculty Research, Scholarly, and Creative Activity

Advancements in robotic systems aimed at improving mobility for individuals with disabilities have required more sophisticated control and navigation methods. Traditional control approaches often lack the complexity and adaptability needed for the high-dimensional nature of human activities. Consequently, reinforcement learning (RL) has emerged as a dynamic and effective framework for managing robotic actions in complex and unpredictable human environments. This article reviews the integration of RL in robotic systems for enhancing the mobility of individuals with disabilities, addressing the limitations of traditional control methods in complex and unpredictable environments. We critically analyze various RL algorithms, discussing their advantages and challenges …

Computational Approaches To Understanding The Proton-Coupled Electron Transfer Reactions In Ribonucleotide Reductase, Jiayun Zhong

Yale Graduate School of Arts and Sciences Dissertations

Proton-coupled electron transfer (PCET) is a fundamental chemical process where both an electron and a proton are transferred simultaneously or sequentially, playing a key role in various biological and chemical systems, including enzymatic reactions and energy conversion. This thesis investigates the PCET reactions in ribonucleotide reductase (RNR), a critical enzyme responsible for DNA synthesis and repair in all living organisms. While significant progress has been made in understanding RNR's PCET pathway, several gaps remain, particularly regarding the specific mechanisms and energetics of individual PCET steps, the role of conformational dynamics, and the influence of water molecules. Through quantum mechanical/molecular mechanical …

Volunteering And Spiritual Practices: A Cross-Country Analysis In The Seventh-Day Adventist Context, Elbert Kuhn

Doctor of Ministry Projects

Problem

Although the number of Seventh-day Adventist (SDA) volunteers worldwide has increased dramatically, the Church continues to face challenges in engaging people, particularly young adults, in volunteer and mission projects on a global scale. While interest in volunteering is growing, especially in countries within the southern hemisphere, the percentage of participation remains disproportionately small in comparison to the global church membership. Given this disparity, there is a pressing need to research the impact of the volunteer experience on spiritual practices and discipline. Understanding how volunteering influences young adults’ spiritual growth is critical to developing strategies that can effectively engage more …

Evaluating Annual Precipitation Extremes In The Us Great Plains Using Prism Data, Sumiaya Amin Preota, Gaurav Talukdar, Sam Zipper

School of Earth, Environmental, & Marine Sciences Faculty Publications

Understanding hydroclimatic extremes in the U.S. Great Plains (USGP) is crucial for effective water resource management, resiliency of agricultural systems, and mitigation of climate change impacts. This study examines changing hydroclimatic conditions in the USGP, with a focus on annual-resolution precipitation trends and extremes over the past 119 years (1904–2022) using precipitation data from the gridded PRISM climate dataset. We categorized annual-scale precipitation totals into six categories of hydroclimatic extremes: (1) isolated wet extremes, (2) isolated dry extremes, (3) dry-to-dry recurring extremes, (4) wet-to-wet recurring extremes, (5) dry-to-wet whiplash extremes, and (6) wet-to-dry whiplash extremes. “Recurring” and “whiplash” are both …

Nesting Population Trend Of The Leatherback Sea Turtle In Bocas Del Toro Province And Comarca Ngäbe-Buglé, Panama For The Period 2002–2022, Sonia Gutiérrez Parejo, Susan E. Piacenza, Raúl García, Cristina Ordóñez, Roldán A. Valverde

School of Earth, Environmental, & Marine Sciences Faculty Publications

Sea turtle biologists have made sustained efforts to understand the global status of leatherback sea turtle populations. However, despite progress in assessments, demographics, and ecology, key uncertainties persist in tracking leatherback population trends. Trend analyses have historically focused on nesting beaches, with nest counts providing a widely used index for population abundance. Here, we analysed 20 years of annual nest abundance at four main nesting beaches (Soropta, Bluff, Playa Larga and Chiriquí) in Bocas del Toro province and the Comarca Ngäbe-Buglé, Panama, which constitute the largest nesting leatherback sea turtle population in Central America. We conducted daily nest counts during …

Dataset On Indoor And Outdoor Pm2.5 Concentrations At Two Residences Using Low-Cost Sensors In The Rio Grande Valley Region Of South Texas, Kabir Bahadur Shah, Sai Deepak Pinakana, Mkhitar A. Hobosyan, Armando Montes, Amit U. Raysoni

School of Earth, Environmental, & Marine Sciences Faculty Publications

Fine particulate matter (PM2.5) is one of the criteria air pollutants associated with adverse respiratory and cardiovascular health effects. This dataset contains hourly and daily averaged measurements of PM2.5 concentrations (µg/m3) collected from two residential homes in the Rio Grande Valley (RGV) Region of South Texas, using PurpleAir-II-SD low-cost sensor. In addition, the dataset also includes temperature (ºC) and relative humidity (%) measured by the sensors. The data was collected for one month during the summer season from indoor (kitchen) and outdoor (front yard) environments at two locations: Home-1 in Weslaco City from June 16, 2024, to July 16, 2024, …

Whole Genome Sequence Analysis Of Low-Density Lipoprotein Cholesterol Across 246 K Individuals, Margaret Sunitha Selvaraj, Lisa De Las Fuentes, Susan K. Dutcher, Et Al.

2020-Current year OA Pubs

No abstract provided.

Dfcp1 Is A Regulator Of Starvation-Driven Atgl-Mediated Lipid Droplet Lipolysis, Victoria A Ismail, Meg Schuetz, Zak N Baker, Jean A Castillo-Badillo, Teri V Naismith, David J Pagliarini, David J Kast

2020-Current year OA Pubs

Lipid droplets (LDs) are transient lipid storage organelles that can be readily tapped to resupply cells with energy or lipid building blocks, and therefore play a central role in cellular metabolism. Double FYVE Domain Containing Protein 1 (DFCP1/ZFYVE1) has emerged as a key regulator of LD metabolism, where the nucleotide-dependent accumulation of DFCP1 on LDs influences their size, number, and dynamics. Here we show that DFCP1 regulates lipid metabolism by directly modulating the activity of Adipose Triglyceride Lipase (ATGL/PNPLA2), the rate-limiting lipase driving the catabolism of LDs. We show through pharmacological inhibition of key enzymes associated with LD metabolism that …

Exosomes: Historical Evolution And Emerging Roles In Dermatology, Nina Schur, Luna Samman, Milaan Shah, Victoria Dukharan, Carol Stegura, Luke Broughton, Todd Schlesinger

GME Publications

Background: Exosomes are a nanoscale extracellular vesicles derived from different cell types that have been investigated for various clinical applications, including functioning as biomarkers and use as direct therapeutics. Given the role of exosomes in multiple pathophysiologic pathways and potential practical applications, they have garnered significant interest in the scientific community but much is still unknown about their development and use.

Aims: This literature review covers the background, mechanisms of action, use as biomarkers, methods of application, and direct therapeutic applications of exosomes.

Methods: A literature review on the background and uses of exosomes was conducted. Key articles describing the …

A Strategy To Address Youth Homelessness In The Minneapolis Metro Area For The Southview Seventh-Day Adventist Church, Sean Lee

Doctor of Ministry Projects

Problem

The Seventh-day Adventist Church’s teaching on serving a vulnerable neighbor is a crucial foundation of the identity of church members as the disciples of Jesus. Therefore, each congregation needs to be aware of the needs of the community it serves. Furthermore, it is crucial to identify vulnerable neighbors and develop targeted strategies to address their specific needs and issues. According to government reports and media coverage on the issue of youth homelessness in the Minneapolis and St. Paul metro area, youth homelessness is an existing issue, even though resources are invested to address it. Moreover, research shows that the …

The Mordecai-Esther Mentorship Initiative: A Cross-Gender Mentorship Model For Commissioned Female Pastors In South Central Conference, Latina Carriger

Doctor of Ministry Projects

Problem

In the South Central Conference of Seventh-day Adventists (SCC), while male pastors receive formal mentorship through the ministerial internship program leading up to ordination, female pastors—who are only commissioned and not ordained—often experience a lack of continued mentorship beyond commissioning. This absence hinders their professional development, limits leadership opportunities, and contributes to feelings of isolation. The current mentorship framework does not adequately support the ongoing growth of female pastors in a context where ordination is not extended to women, thereby creating a gap in pastoral leadership development and equity.

Method

This project utilized a qualitative case study design to …

The Interchangeable-Part Structure Of Food And Drug Law, Adam I. Muchmore

FIU Law Review

This Article demonstrates that nested tiers of interchangeable parts serve as the foundation for the regulatory programs administered by the U.S. Food and Drug Administration. Core interchangeable parts used in FDA-administered programs include product categories, prohibitions on adulteration and misbranding, agency-registration requirements, current good manufacturing practices, product standards, marketing authorization requirements, postmarket requirements, and user fees. In each of these areas, Congress or the FDA has engaged in interchangeable-part lawmaking (IPL). IPL occurs when a government takes a portion of its law in one subject area and uses it as a model for its own law in another subject area. …

Agents In A Tangled Bank: An Ecosystem Approach To Ai Regulation, Andrew W. Torrance, Bill Tomlinson

FIU Law Review

As autonomous artificial intelligence agents ("Agents") become increasingly prevalent in society, legal frameworks must evolve to govern their behavior effectively. This article argues that autonomous AI agents must be understood as operating within complex ecosystems of other agents, humans, institutions, and actual biological ecosystems-similar to how biological organisms exist within broader ecosystems. Drawing on established research in multi-agent systems and environmental law, we propose that effective governance of AI agents requires moving beyond just regulation on individual agents to include system-level approaches. We examine how existing legal frameworks handle heterogeneous autonomous entities (humans, corporations, and animals) and explore how these …

Being Pregnant In Someone Else's Body, Jennifer S. Hendricks

FIU Law Review

In the wake of the Dobbs decision overturning the right to abortion, now is a critical time to re-assess how legal feminism theorizes the pregnant body. Before Dobbs, feminist legal scholarship had blazed a path of anti-maternalism, a stance rooted in liberal, formalist notions of equality that denigrates the “feminine” and too often minimizes the importance of reproductive issues both as tools of sex-based subordination in the present and as foundations for liberation in the future. Anti-maternalism is attractive to legal scholars because it minimizes sex and gender differences and may appear to be gender-inclusive. It has produced arguments that …

Nevada’S Blockchain Gamble: Can A State Embracing Web3 Technology Lead Probate Courts Into The Digital Age?, Ariel Sweeney

FIU Law Review

Probate stands as a bastion of legal formalism, seemingly resistant to the transformative currents of digital innovation that have swept through other domains of American law. While financial transactions, real property conveyances, and contract execution have increasingly begun exploring the use of Web3 technologies such as blockchain and smart contracts, estate and probate law remain tethered to paper-based procedures and rigid execution requirements. Nevada was the first state to provide legal support for Web3 technology, amending its Uniform Electronic Transactions Act statutes in 2017 to recognize blockchain-based transactions as valid and judicially enforceable. Yet despite this progressive legislative framework, the …

The Abuse Liability Of Oral Nicotine Pouches In Electronic Cigarette Users, Jakob D. Bohland

Graduate Theses, Dissertations, and Problem Reports (ETD)

Oral nicotine pouches (ONPs) are products containing synthetic or tobacco derived nicotine in a cellulose pouch. While relatively novel in their current state, ONPs are increasing in popularity, with little known about their national level prevalence. Extant work has suggested that electronic cigarette (e-cig) users may be interested in ONPs; however, no abuse liability studies have been conducted comparing ONPs directly to e-cigs. In the few abuse liability studies that have been conducted, ONPs have been evaluated in comparison to combustible cigarettes or smokeless tobacco (SLT). These studies suggest ONPs may be less reinforcing than combustible cigarettes or SLT. Therefore, …

Beyond The Byproduct: Exploring Approaches For The Sustainable Valorization Of Underutilized Food Streams, Ian Phillip Israelsen

Graduate Theses, Dissertations, and Problem Reports (ETD)

Commercial food processing creates side-streams that are often underutilized yet hold significant potential for valorization into value-added products for consumer use. This study investigated and compared potential protein recovery and lipid removal potential from buckwheat (BW; Fagopyrum esculentum Moench), brewer’s spent grain (BSG), and coffee silverskin (CSS) using a one-step solvent defatting and a pH-shift protein extraction method. The extraction efficiency yields of extracted protein from CSS were significantly lower than all other samples (p < 0.05). The defatted BW had the highest extracted protein content of all samples (p < 0.05). The sizes of the proteins in the starting materials were observed using LDS-PAGE. These sizes were consistent with published values and were mostly unchanged by defatting or the pH-shift process. The presence of 13S globulins and 2S albumins was confirmed under reducing conditions. Protein extracted from all native samples had lower total free essential amino acids than the starting materials. Native CSS and extracted protein followed this trend, but in defatted CSS and respective extracted protein samples, the extracted proteins had higher free essential amino acid content than the starting materials, sometimes of twofold or greater (p < 0.05). After defatting, the percentage of lipids recovered compared to the original lipid content of the samples was measured. The crude fat content of native and hexane-defatted BW flour was higher than BW flour defatted with ethanol (p < 0.05). The lipid extraction efficiency of all samples ranged from 4.6 ± 1.26%–43.20 ± 14.21%. The mass of the native and defatted starting materials were recorded at each step of processing, with reasonable losses assessed. The major non-polar lipid classes in each starting material were separated using thin-layer chromatography. All samples also displayed the presence of polar lipids. When comparing starting materials, BW and BSG was the most effective for protein extraction, and BSG has the most promise for lipid removal and potential for upcycling. All the examined starting materials show promise for use in food supplementation, especially as native flours. These products are plentiful and considered underutilized or side-stream products.