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Characterization Of Curcumin As A Coating Material For Polymer-Free Stents Interms Of Morphology And Release, Ameliyana R.S.P.A. Yani, Muhammad Kusumawan Herliansyah

Journal of Mechanical Engineering Science and Technology (JMEST)

The use of bare metal stents over the long term often leads to the re-narrowing of blood vessels, prompting a shift to drug-eluting stents (DES). However, the use of polymers in DES has been known to trigger inflammation and thrombosis in the arteries. As an alternative, polymer-free drug-eluting stents (PF-DES) have emerged as a safer option. In this study, curcumin was selected as the primary coating material for PFDES using the electrophoretic deposition method. The effects of varying curcumin concentrations (125 µg/ml, 250 µg/ml, and 500 µg/ml) were examined to understand their impact on deposition morphology, coating weight, chemical bonding …

Impact Of Print Speed And Nozzle Temperature On Tensile Strength Of 3d Printed Abs For Permanent Magnet Turbine Systems, Wirawan Wirawan, Hilmi Iman Firmansyah, Satworo Adiwidodo, Mohammad Sukri Mustapa

Journal of Mechanical Engineering Science and Technology (JMEST)

Operational parameters must be integrated into turbine systems' main components, which are determined by turbine systems' functional requirements. The need for producing component designs more effectively raises the possibility of using additive manufacturing. The study focuses on the optimization of the mechanical properties of the principal components of magnetic turbines manufactured with 3D printers using Acrylonitrile Butadiene Styrene (ABS), by changing the temperature and speed of the nozzle. The approach consisted of modeling a standard test piece in CAD software and producing ABS-based test pieces using a 3D printer with print speeds of 50, 70, 90, and 110 mm/s and …

Characterization Of Bamboo Petung Fiber Reinforced Composites With Environmentally Friendly Enzymes, Rudianto Raharjo, Teguh Dwi Widodo, Redi Bintarto, Fikrul Akbar Alamsyah

Journal of Mechanical Engineering Science and Technology (JMEST)

Natural fiber composites are a good choice for many businesses uses because of their better mechanical properties and are friendly environment. Researchers are currently looking into bamboo petung fiber (BPF) and epoxy composites as alternative to synthetic fibers and products made from petroleum. This study's goal is to improve the overall performance of these composites while reducing the need for non-organic materials. This study used the various concentration of bromelain enzyme in BPF to changes the mechanical and physical properties of epoxy composites made from BPF. Composites were characterized the mechanical properties including tensile strength using tensile tester, impact strength …

Surface Analysis Of Bacterial Cellulose Membrane Made From Biowaste Added With Zno Nanopowder, Naufal Rizky Amasda, Heru Suryanto, Uun Yanuhar, Aminnudin Aminnudin, Fajar Nusantara, Quota Alief Sias

Journal of Mechanical Engineering Science and Technology (JMEST)

Utilization of pineapple biowaste is important to increase the value added to biowaste and solve the environmental problem. So, the study objective is to synthesize membranes of bacterial cellulose made from pineapple biowaste and characterize the surface morphology and porosity of the membrane after being added with ZnO nanopowder. The study starts with extracting biowaste as a bacterial cellulose culture medium for the fermentation process. The obtained pellicle was crushed and homogenized with the added ZnO nanopowder in the presence of ultrasonic waves. The membrane is dried in the oven. The membrane morphology was monitored using scanning electron microscope and …

Fathers’ Experiences With Reunification With The Massachusetts Child Welfare System, Phernel Joseph Manigat

Walden Dissertations and Doctoral Studies

This study focused on fathers’ experiences with the Massachusetts child welfare system (MCWS) or the Department of Children and Families (DCF) during the reunification process with their children, particularly those fathers who received sole custody of their children during this process. Researchers have demonstrated that fathers are minimally engaged and mostly ignored in the child welfare system (CWS). A research gap was identified regarding the experiences of fathers who received sole custody of their children through the CWS. The purpose of this study was to explore these fathers’ experiences with the MCWS or the DCF during the reunification process with …

Retrotransposon Methylation Profiles And Survival In Black Women With High-Grade Serous Ovarian Carcinoma., Christelle Colin-Leitzinger, Katherine A. Lawson-Michod, Courtney E. Johnson, Irma M. Vlasac, Sean Yoder, Tania Mesa, Dana Roeber, Chad Huff, Michelle A T Hildebrandt, Kristin Haller, Anthony J. Alberg, Elisa V. Bandera, Melissa Bondy, Michele L. Cote, Theresa Hastert, Edward S. Peters, Paul D. Terry, Andrew B. Lawson, Andrew Berchuck, Brooke L. Fridley, Jing-Yi Chern, Jennifer A. Doherty, Jeffrey R. Marks, Joellen M. Schildkraut, Brock C. Christensen, Lucas A. Salas, Lauren C. Peres

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Retrotransposons (REs) constitute nearly half of the genome and include long terminal repeat (LTR) elements, Long INterspersed Elements (LINE), and Short INterspersed Elements (SINE). REs are typically silenced in somatic tissues via DNA methylation but can be reactivated through DNA hypomethylation, potentially impacting gene regulation. Here, we investigate genome-scale profiles of RE methylation in high-grade serous ovarian carcinoma (HGSOC) and associations with survival among Black women.

METHODS: Methylation levels of LTR, LINE-1, and Alu (type of SINE) in 200 HGSOC tumors were predicted using a random forest approach and clustered using multiple consensus algorithms. Associations between RE methylation clusters …

Authentication Of Kaffir Lime Leaf Oil (Citrus Hystrix D.C.) In Products Using Ftir Combined With Chemometrics, Jeffry Jeffry, Any Guntarti, Nina Salamah

Pharmaceutical Sciences and Research

Indonesia is rich in aromatic plants, producing approximately 40 types of essential oils used in various industries, including health and aromatherapy. Essential oils have significant potential but face high rates of adulteration. This study aimed to identify kaffir lime leaf oil (Citrus hystrix D.C.), to determine the essential oil profile, and to detect adulteration in commercial oil products. The methods used involved steam distillation and characterization tests of kaffir lime leaf essential oil, including yield percentage and organoleptic, density, refractive index, and solubility in alcohol. An essential oil content test and adulteration detection using FTIR combined with chemometrics were …

Retrotransposon Methylation Profiles And Survival In Black Women With High-Grade Serous Ovarian Carcinoma, Christelle Colin-Leitzinger, Katherine A Lawson-Michod, Courtney E Johnson, Irma M Vlasac, Sean Yoder, Tania Mesa, Dana Roeber, Chad Huff, Michelle A T Hildebrandt, Kristin Haller, Anthony J Alberg, Elisa V Bandera, Melissa Bondy, Michele L Cote, Theresa Hastert, Edward S Peters, Paul D Terry, Andrew B Lawson, Andrew Berchuck, Brooke L Fridley, Jing-Yi Chern, Jennifer A Doherty, Jeffrey R Marks, Joellen M Schildkraut, Brock C Christensen, Lucas A Salas, Lauren C Peres

Faculty, Staff and Student Publications

Introduction: Retrotransposons (REs) constitute nearly half of the genome and include long terminal repeat (LTR) elements, Long INterspersed Elements (LINE), and Short INterspersed Elements (SINE). REs are typically silenced in somatic tissues via DNA methylation but can be reactivated through DNA hypomethylation, potentially impacting gene regulation. Here, we investigate genome-scale profiles of RE methylation in high-grade serous ovarian carcinoma (HGSOC) and associations with survival among Black women.

Methods: Methylation levels of LTR, LINE-1, and Alu (type of SINE) in 200 HGSOC tumors were predicted using a random forest approach and clustered using multiple consensus algorithms. Associations between RE methylation clusters …

Logged Out Or Logged In? Stress, Burnout, And Job Satisfaction Between Remote And In-Person Workers, Ryan H. Nguyen

McNair Scholars Research

There is an increasing concern about job-related stress, burnout, and satisfaction. This study explores stress, burnout, and job satisfaction patterns among remote and in-person workers. The sample for this study comprised 88 adults recruited through social media who voluntarily completed a 40-item Google Forms survey. The survey included 10 demographic items and incorporated items from three inventories: Perceived Stress Scale (PSS), Copenhagen Burnout Inventory (CBI), and Aggregate Job Satisfaction Scale (AJSS). The data were analyzed quantitatively using Pearson correlation and independent samples t-tests to assess the relationship among burnout, work-related stress, and job satisfaction, and to determine the influence of …

Data-Driven Approach To Dynamic Resting State Functional Connectivity In Post-Traumatic Stress Disorder: An Enigma-Pgc Ptsd Study, Jacklynn M. Fitzgerald

Psychology Faculty Research and Publications

Using functional magnetic resonance imaging (fMRI), symptoms of posttraumatic stress disorder (PTSD) have been associated with aberrations in brain networks in the absence of a given cognitive demand or task, called resting-state networks. Prior work has focused on disruption in the static functional connectivity (FC) among specific regions constrained by a priori hypotheses. However, dynamic FC, an approach that examines brain network characteristics over time, may provide a more sensitive measure to understand the network properties underlying dysfunction in PTSD. Further, using a data-driven analytic approach may reveal the contribution of other larger network disturbances beyond those revealed by hypothesis-driven …

2021-05-11 Leadership Council Minutes, Susie Salazar

Executive Council Minutes

No abstract provided.

Dissecting Macrophage Metabolism In Metabolic Liver Disease, Mandy Mei-Ying Chan

Arts & Sciences Graduate Student Theses and Dissertations

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of chronic liver disease around the globe; however, the mechanisms that lead to the progression of metabolic liver disease are poorly understood. Liver-resident macrophages, known as Kupffer cells (KCs), are the largest population of macrophage in the human body, playing a critical role in immune sensing and tissue homeostasis. In the context of MASLD, KCs undergo cell death through an unclear mechanism, and monocytes enter the liver where they differentiate into macrophages. Next-generation sequencing and spatial-omics studies have revealed significant, heterogeneity in the recruited macrophage populations in both human …

Examining Light-Circadian Interactions In Regulation Of Amyloid Plaque Pathology, Melvin William King

Arts & Sciences Graduate Student Theses and Dissertations

Circadian disruption has long been appreciated as a downstream consequence of Alzheimer’s Disease in humans. However, an upstream role for circadian disruption in regulating AD pathology remains an open question. The mammalian circadian system is hierarchical, with cellular clocks – driven largely by BMAL1 – synchronized by the hypothalamic SCN (suprachiasmatic nucleus) via a combination of hormonal and synaptic cues. To assess the relative contributions of each component to Alzheimer’s Disease pathology, we crossed mice harboring either microglial (Cx3cr1/Lyz2-Cre) or GABAergic (VGAT-iCre, expressed in more than 95% of the SCN) BMAL1-knockout to mouse models of Aβ aggregation (5xFAD; APP/PS1-21), which …

Protective Multi-Stressor Interactions In The Anthropocene: Key Considerations For Investigating Cross-Tolerance In A Conservation Context, Essie M Rodgers, Simone Baldanzi, Michael Collins, W Wesley Dowd, Lauric Feugere, Giovanna Mottola, Fanny Vermandele, Daniel F Gomez Isaza

School of Biological and Marine Sciences

In the Anthropocene, species are increasingly faced with multiple stressors that are more severe and less predictable than before. While multiple stressors often interact to affect organisms negatively, sometimes these interactions can be beneficial, enhancing resilience through cross-protection. Cross-protection interactions occur when exposure to one stressor, such as elevated temperature, enhances an organism’s tolerance to a different stressor, like hypoxia, through shared protective mechanisms or signaling pathways. Understanding the potential for cross-protection to combat rapid and diverse environmental change is crucial for conservation, as it potentially alters the predicted consequences of such change. Here, we outline 10 key considerations for …

Unveiling Spatial Heterogeneity In Medulloblastoma: A Multi-Omics Analysis Of Cellular State And Geographical Organization, Jiankang Li, Hailong Liu, Ziwei Wang, Jiao Zhang, Xuan Chen, Craig Daniels, Xiaochong Wu, Olivier Saulnier, Hiromichi Suzuki, Pasqualino De Antonellis, Alexandra Rasnitsyn, Winnie Ong, Evan Y Wang, Liam D Hendrikse, Yu Su, Yu Tian, Dongming Han, Ruohan Wang, Jialin Mo, Fei Liu, Kaiwen Deng, Dongyang Wang, Zhaoyang Feng, Yifei Jiang, Yanong Li, Yuting Ma, Zijia Liu, Meiyu Li, Peiyi Tian, Yanfeng Shi, Yong Jiang, Tao Yang, Shouwei Li, Jianfeng Liang, Jingchuan Wu, Ying Wang, Wanjing Zou, Yina Jiang, Lusheng Wang, Fang Chen, Xin Jin, Shuaicheng Li, Xiaoguang Qiu, Chunde Li, Ya Gao, Yujie Tang, Michael D Taylor, Tao Jiang

Faculty, Staff and Students Publications

Background: Despite numerous studies on medulloblastoma (MB) cell heterogeneity, the spatial characteristics of cellular states remain unclear.

Methods: We analyze single-nucleus and spatial transcriptomes and chromatin accessibility from human MB spanning four subgroups, to identify malignant cell populations and describe the spatial evolutionary trajectories. The spatial copy number variations (CNVs) patterns and niches were analyzed to investigate the cellular interactions.

Results: Three main malignant cell populations were identified, including progenitor-like, cycling, and differentiated populations. Gene signatures of cell populations strongly correlate to clinical outcomes. These tumor cell populations are geographically organized as stem-like and mature regions, highlighting their spatially heterogeneous …

Systematic Review Of Parkinsonism In Cerebrotendinous Xanthomatosis, Jennifer Hanson, Penelope E Bonnen

Faculty, Staff and Students Publications

Background: Cerebrotendinous Xanthomatosis (CTX) is a rare, inherited metabolic disease caused by pathogenic variants in CYP27A1. The clinical presentation of this progressive disease includes cognitive deficits, ataxia, peripheral neuropathy, and pyramidal signs, as well as bilateral cataracts and tendon xanthomas. In some cases, CTX also includes parkinsonism. The goals of this study are to develop a data source that provides improved characterization and awareness of parkinsonism in CTX.

Methods: We conducted a systematic review of the literature according to PRISMA guidelines to identify all published individuals diagnosed with CTX and parkinsonism. Clinical signs, imaging findings and treatment response to …

Integrating Circulating Tumor Dna Into Clinical Management Of Colorectal Cancer: Practical Implications And Therapeutic Challenges, Nikhil Vojjala, Viktoriya Gibatova, Raj N Shah, Sakshi Singal, Rishab Prabhu, Geetha Krishnamoorthy, Karen Riggins, Nagaishwarya Moka

Faculty, Staff and Students Publications

The American Cancer Society estimates that over 152,000 new cases of colorectal cancer (CRC) were diagnosed in 2024, with more than 105,000 cases affecting the colon and 46,000 involving the rectum. CRC remains the second leading cause of cancer-related deaths in the United States, with an estimated 53,010 deaths in 2024. In the era of precision medicine, which incorporates molecular and environmental information into clinical decision-making, identifying patients harboring a deficiency in Deoxyribonucleic acid (DNA) repair allowed for targeted immunotherapies and significantly reduced CRC-related mortality. A significant advancement in this domain is the application of liquid biopsy, which has emerged …

Myth And Reality, Mircea Eliade

Hannah Arendt Marginalia - All

New York, Harper & Row, 1967

Call #: BL304 .E413

Contains marginalia, underlining, and is inscribed by the author

PDF Information: 62 pages – 22.5 MB

Achieving Outcomes In Analytical Chemistry While Focusing On Active Learning And Self-Care, Gretchen E. Potts Ph.D.

UTC Spring Research and Arts Conference

Pedagogy can support self-care and student outcomes in the chemistry classroom. In fact, intentional course design to support the whole student may improve overall student outcomes. A quantitative analysis lecture course that was designed synchronously online during COVID was transitioned to a face-to-face environment in an active learning classroom. Discussion boards were converted to daily group work that highlighted collaboration. Small adjustments were implemented to the course and syllabus design to help students manage stress and to encourage self-care. Frequent anonymous check-ins were used to monitor student learning progression. Additional anonymous prompts encouraged students to share study tips, how to …

Artificial Wetlands Provide Hope For Municipal Sewage Effluent Treatment And Biodiversity Declines, William T. Bryant

UTC Spring Research and Arts Conference

Wetlands provide habitat for a multitude of species worldwide and exist on almost every continent. They act as water filtration systems, cycle organic and inorganic nutrients, prevent flooding and mitigate storm damage. As the human population continues to expand and cities continue expanding, more infrastructure is needed for water treatment and providing green spaces for citizens to enjoy. This literature review analyzes the current data on the effectiveness of constructed wetlands in the treatment of sewage effluent and how they impact the biodiversity of the local ecosystem. The databases Web of Science, ProQuest and Agriculture, Ecosystems and Environment were utilized. …

Being, Man & Death: A Key To Heidegger, James M. Demske

Hannah Arendt Marginalia - All

University Press of Kentucky, 1970

Call #: B3279.H49 D4513

Light underlining & moderate marginal lining.

PDF Information: 37 pages – 16mb

The Survivor: An Anatomy Of Life In The Death Camps, Terrence Des Pres

Hannah Arendt Marginalia - All

New York : Oxford University Press, 1976

Call #: D810.J4 D474 1976

Contains edited markings, marginalia, and is an advance proof copy that is uncorrected

PDF Information: 69 pages – 4.6MB

Unless Peace Comes; A Scientific Forecast Of New Weapons, Nigel Calder

Hannah Arendt Marginalia - All

New York, Viking Press, 1968

Call #: U104 .C155 1968

Contains underlining and marginal lining.

PDF Information: 48 pages – 19mb

An Essay On Man, Ernest Cassirer

Hannah Arendt Marginalia - All

Garden City, NY: Doubleday, 1953 [c1944]

Call #: B3216.C33 E8 1953

Marginalia , underlining and marginal lining

PDF Information: 14 pages – 4 MB

Comparative Analysis Of Linear And Non-Linear Feature Selection For Breast Cancer Detection With Shap Analysis, Hamza Sabo Maccido

AUIQ Technical Engineering Science

Breast cancer remains one of the leading causes of mortality worldwide, emphasizing the critical need for accurate and efficient diagnostic tools. This study investigates the effectiveness of combining linear and non-linear feature selection methods-Principal Component Analysis (PCA), Pearson Correlation Coefficient (PCC), and Backpropagation Neural Networks (BNN) to improve breast cancer classification using machine learning models. We utilized the Wisconsin Breast Cancer Dataset to evaluate the performance of five classifiers-Support Vector Machine (SVM), K-Nearest Neighbor (KNN), Logistic Regression (LR), Decision Tree (DT), Naïve Bayes (NB) and Artificial Neural Network (ANN). The results demonstrated that BNN-selected features consistently outperformed PCA and PCC …

Retracted: Dynamics And Stability Analysis Of 8-Dimensional Hyperchaotic Systems: Study Of Lyapunov Exponents, Abdulsattar Abdullah Hamad, Nida Muhsin Ali, Muayyad Mahmood Khalil

Iraqi Journal for Computer Science and Mathematics

This research explores the complex dynamics of an 8D hyperchaotic system, focusing on its trajectory stability and behavior under various control parameters. By using numerical simulations, we investigate the relationship between the Lyapunov components and the stability of the system. It provides a quantitative measure of the chaos within the model of the matrix, whose derivation consists of the system's sensitivity to perturbation, simulating chaotic systems in high dimensions faces challenges such as high computational resource demands. Difficulty in ensuring numerical convergence and stability. The results highlight the profound impact of control parameters on the dynamic behavior of hyperchaotic systems. …

Corneal Elevation Maps Patterns Classification Using Correlation Method, Sura M. Ahmed, Nebras H. Ghaeb, Salman Yussof, Noor T. Al-Sharify, Husam Yahya Nser, Zainab T. Al-Sharify, Ong Hang See, Leong Yeng Weng

Iraqi Journal for Computer Science and Mathematics

The ophthalmologist uses various techniques to diagnose corneal abnormalities, including corneal topography and tomography devices. Currently generated color corneal elevation surface maps from topographic imaging devices are essential for detecting ocular diseases, while accurately classifying these maps to differentiate between different shapes remains an issue. This study aims to assess and compare parameters of the front and back corneal surface elevation map patterns of normal/abnormal corneas. Two hundred cases were randomly taken (100 normal and 100 abnormal) with a single normal reference image, and then an additional 25 cases were added later for the optimization process. The preprocessing of all …

Computational And In Vitro Investigation Of P. Crocatum Bioactive Compounds As Pancreatic Lipase Inhibitors, Gusnia Meilin Gholam, Dimas Andrianto, Dewi Anggraini Septaningsih, Mega Safithri

Karbala International Journal of Modern Science

Obesity, a prevalent metabolic disorder characterized by excessive fat accumulation, can severely affect overall health if left untreated. This study investigated the potential of a 70% ethanol extract from Piper crocatum (red betel) leaves as an in vitro inhibitor of pancreatic lipase (PL), supported by computational analyses to identify alternative compounds to orlistat. The phytochemical profile was characterized using LC-MS/MS, revealing alkaloids and terpenoids with contents of 1.1 ± 0.01 mg CE/g and 3.14 ± 0.3 mg UAE/g, respectively. The extract exhibited 49 ± 9.1% inhibition of PL activity. Molecular docking identified three promising compounds: calanolide A (10.43 kcal/mol), myricanone …

Hyperglycemia And Oral Health: A Review Of Dental Clinicians’ Perceptions And Practices Of Blood Glucose Monitoring In The Dental Office, Kathleen Wozniak

Dental Hygiene ETDs

This study aims to review the current practices and perceptions of dentists regarding the likelihood of dental professionals incorporating blood glucose monitoring into patient care protocol of patients with diabetes mellitus and prediabetes in dental offices. A survey link was shared by DentalOffices, a dental resource center. The survey included a series of questions which aimed to review dentists' current attitudes, practices, and considerations for implementation of in-office blood glucose testing as it relates to the treatment of patients with diabetes mellitus. Forty-seven dentists participated in the survey. This study determined blood glucose testing is not a common protocol or …

Baseline Testosterone Levels Peak During The Inactive Period In Male Degus (Octodon Degus), Yuta Sato , '26, Tate M. S. Garcia , '26, Josephine S. Low , '27, Carolyn M. Bauer

Biology Faculty Works

The steroid hormone testosterone is important for stimulating male reproductive processes including territory acquisition, mating displays, and spermatogenesis. When examining the relative effects of testosterone on reproductive processes, it is most reasonable to focus on peak baseline testosterone levels, especially for reproductive processes that may occur during specific times of day, such as mating and spermatogenesis. However, some studies have not found consistent positive relationships between circulating testosterone levels and reproductive variables. These nonsignificant relationships could be driven by methodology, as most studies in wild, free-living animals collect blood samples during an animals' active period, yet many species show peak …