Digital Commons Network^™

Computational Prediction Of Hemolysis In Laminar Non-Newtonian Fluid, Nasim Gholizadeh

Theses and Dissertations

Hemolysis, the rupture of red blood cells (RBCs), is a critical concern in blood-circulating devices, requiring accurate predictions to ensure patient safety. This study investigates the sensitivity of hemolysis predictions to variations in viscosity models and hemolysis coefficients under complex flow conditions. Computational Fluid Dynamics (CFD) simulations were conducted using Ansys Fluent and OpenFoam on identical meshes with the FDA benchmark nozzle model. Under laminar flow conditions, CFD frameworks accurately predicted global variables, but variations in derived quantities, such as strain rate and vorticity, emerged due to differences in numerical solvers and gradient evaluation methods. These variations affected predictions of …

The Effect Of Metallothionein-3 On Global Gene Expression And Transcriptome Of Kidney Progenitor And Urothelial Cells, Julia Kochanowski

Theses and Dissertations

Metallothioneins (MT) are low molecular weight, cysteine-rich, metal-binding proteins that protect against metal toxicity. MTs have several functions, such as transport of metals, detoxification of metals, and protection from metal toxicity. MT-3, first called growth inhibitory factor, was originally discovered as the Alzheimer’s disease gene. MT-3 has a unique structure with 7 additional amino acids. The role of MT-3 is unknown. Some studies suggest MT-3 plays a role in the immune system and with cisplatin resistance. RPTEC/TERT1 cell line is an immortalized cell line from the human proximal tubule of an adult kidney. It was determined that RPTEC/TERT1 cultures consisted …

Investigating The Role Of Keratin 6 And Sox2 In Regulating Growth, Stemness, Basal/Squamous Expression, And Chemotherapy Response In Muscle-Invasive Urothelial Carcinoma, Nelofar Nargis

Theses and Dissertations

Urothelial carcinoma (UC) is a prevalent and aggressive malignancy arising in urothelial cells, with arsenic exposure recognized as a significant environmental risk factor. It is categorized into two primary subtypes based on the extent of cancer progression beyond the bladder’s muscle wall: non-muscle-invasive urothelial carcinoma (NMIUC) and muscle-invasive urothelial carcinoma (MIUC). While NMIUC is associated with a relatively favorable prognosis, progression to MIUC is more aggressive and leads to significantly worse outcomes, including poor treatment response and increased metastasis. Squamous differentiation (SD) in UC is an emerging hallmark of aggressive UC, with patients often having poor prognoses and developing chemoresistance, …

From Emily To Loralei To Rory: A Qualitative Textual Analysis Of Scripts From Gilmore Girls For Real-World Application, Erin Mccann

Theses and Dissertations

In the realm of interpersonal communication and intrafamilial research, one dynamic, the mother and daughter pairing, is especially poignant in exploring the ties of closeness, the openness of communication and the potential for long-term impact on a daughter’s development. When studying the mother and daughter dynamic through a work of fiction, patterns can be observed without bias, allowing for evaluation of the strength of relationship and identification of broader implication to the discipline of family communication. In this study, a textual analysis was conducted evaluating 21 exemplary episodes of the 2000s television show Gilmore Girls focused entirely on the interactions …

Addressing The Impact Of Unlicensed And Under-Licensed Teachers In Pk-12 Schools: How School Administrators Offer Support, Taylor Topinka

Theses and Dissertations

As the impact of the teacher shortage grows, more teachers are entering classrooms with incomplete teacher licensure. Related literature affirms that new-to-profession teachers experience what Danielson (1999) described as a “sink or swim in the deep end of the pool” culture as they attempt to navigate the beginning of their teaching career with an incomplete license or no license entirely (p. 251). The influx of partially-licensed teachers engaging students is a dilemma created by the growth of the teacher shortage. The purpose of this study was to address the impact of unlicensed and under-licensed teachers on student growth and achievement …

Spatial And Temporal Assessment Of Meteorological Drought Using The Standardized Precipitation Index (Spi) And Its Effect On Crop Yield Over The Corn Belt Region Of The United States From 2000 To 2023, Victor Araya

Theses and Dissertations

Climate change and global warming have contributed to extreme weather events and patterns, including severe flooding, earthquakes, wildfires, and drought. Drought happens to be the deadliest catastrophic event around the world. Drought's impact on ecosystems and local communities has been increasing in many parts of the world, including the United States and, most importantly, the corn Belt, which also happens to be the country's food basket. Understanding drought prediction and mitigation can be investigated through drought indices. The Standardized Precipitation Index (SPI) is considered the most reliable in this study. It is used in this study to present the critical …

Gender And Family Differences In Faculty Motivation, Allyssa Jean Baumbach

Theses and Dissertations

This three-article dissertation examines gender and family differences in faculty motivation. Faculty motivation has primarily been studied in the context of development but has only recently begun to focus on productivity and success. Further, studies of faculty motivation do not provide in depth analysis of gender and family differences. Therefore, the current program of research uses the Self-Determination Theory to examine gender and family differences in faculty motivation and considers how traditional gender norms may contribute to these differences. The first study explored if gender difference existed. Data from a small sample of faculty (N=118) from two universities in the …

An Explainable Ai Framework For Detecting Harmful Algal Blooms (Habs) In Freshwater Lakes, Meera Gopinath Sujatha

Theses and Dissertations

The increase in economic impacts due to the rapid growth of harmful algal blooms (HABs) in freshwater lakes has prompted the development of monitoring and prediction systems. However, limited target data hinders reliable predictions on HAB formations. To address this limitation, this dissertation focuses on providing solutions through data-driven,interpretable, and explainable machine learning models. In Chapter 3, an interpretable multivariate regression model such as Vector Autoregressive (VAR) was used to analyze the important factors that contribute to the formation of cyanobacteria in lakes. The causality tests performed on multiple water quality data helped to determine Alkalinity, Chlorophyll-a (Chl-a), andWater Temperature …

Teaching Agroecology Through Play: A Board Game On Companion Planting Using Agroecological Principles, Ashmita Das, Julie Capito-Hernandez, Estelí Jiménez-Soto

School of Geosciences Faculty and Staff Publications

Board games themed around environmental topics are promising tools for promoting awareness of complex sustainability issues, as the materiality, sociality, and multidimensionality of gameplay can help overcome some of the inherent limitations of more traditional learning formats. To explore the potential relevance of board games for communicating about agrifood system topics in particular, we designed and tested a game called Companion: An Agroecological Adventure, in which players take on the role of community gardeners who must apply both social and ecological principles of agroecology to cultivate a thriving garden plot. In this paper, we present the results of a study …

Food Sovereignty Among Migrant Farmworkers: The Role Of Agrobiodiversity For Autonomy And Resistance In A Mexican Coffee Plantation, Estelí Jiménez-Soto, Sanya Cowal, April Lopez

School of Geosciences Faculty and Staff Publications

Coffee agroecosystems represent the economic base for thousands of small growers and agricultural workers, as well as a significant proportion of many regional economies in Latin America. Every year, the production of coffee in this region attracts a great number of laborers and their families, particularly during the harvest season. Despite being essential workers in the food system, agricultural workers continue to be one of the most marginalized actors in the coffee production chain. Even with an environment of precarity, agricultural workers exercise their autonomy and food sovereignty—the process by which agricultural workers, in this case, define their food system …

Exploring The State Of Homelessness In Franklin And Licking County, Justice Ofosuhene Jr.

Student Scholarship

No abstract provided.

Maternal Incarceration, Adolescent Delinquency, And Siblings, Tracey L. Woodard

Midwest Social Sciences Journal

Researchers have estimated that approximately 2.7 million children in the United States have a parent in jail or prison. Since 1991, the number of children with a father in prison grew by 77%, while the number of children with a mother in prison more than doubled (131%). In examining the consequences of maternal incarceration on children, many researchers have found an association between negative child outcomes and maternal incarceration. However, not all research has produced the same conclusions, thus yielding heterogeneous findings. It is essential to understand the factors that may explain the variation in outcomes of children experiencing maternal …

“Finally Girls Hitting A Celly:” Emotions And Gender Embodiment In Competitive Swimmers’ Post-Race Celebrations, Lauren Q. Rohde , '25

Senior Theses, Projects, and Awards

In athletic competitions, the moment of achievement is often extremely cathartic and results in a visible celebration. In competitive swimming, these reactions to success are isolated to the end of a race, completely individual, and often feature interaction with one’s surroundings, such as the water or lane lines. These moments are also highly visible and usually well-photographed, and the visibility of these actions contributes to a growing culture in the sport around post-race celebrations. The exposure of the body in competitive swimming additionally contributes to its visibility, further complicating behaviors and norms around celebrating race outcomes. This research aims to …

Dance Improvisation And Kinematics: Describing Spontaneous Motion Among Movers, Fallon Simone Doshi Brackley

Student Scholarship

No abstract provided.

Scoping Review Of Machine Learning Techniques In Marker-Based Clinical Gait Analysis, Kevin N. Dibbern, Maddalena G. Krzak, Alejandro Olivas, Mark V. Albert, Joseph J. Krzak, Karen M. Kruger

Biomedical Engineering Faculty Research and Publications

The recent proliferation of novel machine learning techniques in quantitative marker-based 3D gait analysis (3DGA) has shown promise for improving interpretations of clinical gait analysis. The objective of this study was to characterize the state of the literature on using machine learning in the analysis of marker-based 3D gait analysis to provide clinical insights that may be used to improve clinical analysis and care. Methods: A scoping review of the literature was conducted using the PubMed and Web of Science databases. Search terms from eight relevant articles were identified by the authors and added to by experts in clinical gait …

Advancing The Environmental Dna And Rna Toolkit For Aquatic Ecosystem Monitoring And Management, Xavier Pochon, Holly A. Bowers, Anastasija Zaiko, Susanna A. Wood

Faculty Research, Scholarly, and Creative Activity

The application of environmental DNA (eDNA) and RNA (eRNA) technologies to aquatic ecosystem monitoring and management has increased rapidly in the last decade. These methods are providing many new and exciting opportunities for enhanced biodiversity assessment, ecological health evaluation, and species detection. This special issue of PeerJ Life and Environment brings together 20 innovative studies that collectively advance the eDNA toolkit. Four key themes are covered: (i) Methodological advancements, (ii) Ecological health assessments and biomonitoring, (iii) Species detection, and (iv) Application and management. The studies cover a suite of topics including; optimizing sample collection, developing species-specific assays, evaluating bioindicator species, …

Does Mean Arterial Pressure Augmentation Improve Neurological Recovery Of Blunt Spinal Cord Injuries: An East Multicenter Trial., Aimee Lariccia, Stephanie Doris, Bhairav Shah, Tanisha Kashikar, Erik Teicher, Lindsey Perea, Jennifer Huber, Malia Eischen, H Akin Erol, Michael Steven Farrell, Lauren Colom, Stephanie Scott, Brian Daley, James Bardes, Gregory Schaefer, Melissa Moncrief, William Devoe, Ryan Peter Dumas, Caitlin Anne Fitzgerald, William Brigode, John D Berne, Dalier R Mederos, Scott Armen, Melissa Linskey Dougherty, Asanthi Ratnasekera, Emily Alberto, Alison Smith, Bradley M Dennis, Stephen Gadomski, Jeffry Nahmias, Claudia Alvarez, Salina Wydo, Jennifer Schweinsburg, Carlos H Palacio, M Chance Spalding, Joshua Hill

Trauma and Acute Care Articles

BACKGROUND: Treatment of blunt traumatic spinal cord injuries (SCIs) often includes maintaining elevated mean arterial blood pressures (MAP) to enhance perfusion to the spinal cord. Optimal hyperperfusion protocols and treatment algorithms have yet to be delineated due to a paucity of large volume prospective studies. This study aims to identify predictors of neurological improvement in American Spinal Injury Association (ASIA) impairment score following blunt SCI.

STUDY DESIGN: Prospective (January 10, 2021 to June 1, 2023) multicenter study included blunt SCI patients age >18 with complete neurological examination documented on hospital arrival. Patients were divided into two groups: neurological improvement and …

Reinforcement Learning Methods For Assistive And Rehabilitation Robotic Systems: A Survey, Mojtaba Sharifi, Shreesh Tripathi, Yun Chen, Qiang Zhang, Mahdi Tavakoli

Faculty Research, Scholarly, and Creative Activity

Advancements in robotic systems aimed at improving mobility for individuals with disabilities have required more sophisticated control and navigation methods. Traditional control approaches often lack the complexity and adaptability needed for the high-dimensional nature of human activities. Consequently, reinforcement learning (RL) has emerged as a dynamic and effective framework for managing robotic actions in complex and unpredictable human environments. This article reviews the integration of RL in robotic systems for enhancing the mobility of individuals with disabilities, addressing the limitations of traditional control methods in complex and unpredictable environments. We critically analyze various RL algorithms, discussing their advantages and challenges …

Computational Approaches To Understanding The Proton-Coupled Electron Transfer Reactions In Ribonucleotide Reductase, Jiayun Zhong

Yale Graduate School of Arts and Sciences Dissertations

Proton-coupled electron transfer (PCET) is a fundamental chemical process where both an electron and a proton are transferred simultaneously or sequentially, playing a key role in various biological and chemical systems, including enzymatic reactions and energy conversion. This thesis investigates the PCET reactions in ribonucleotide reductase (RNR), a critical enzyme responsible for DNA synthesis and repair in all living organisms. While significant progress has been made in understanding RNR's PCET pathway, several gaps remain, particularly regarding the specific mechanisms and energetics of individual PCET steps, the role of conformational dynamics, and the influence of water molecules. Through quantum mechanical/molecular mechanical …

Volunteering And Spiritual Practices: A Cross-Country Analysis In The Seventh-Day Adventist Context, Elbert Kuhn

Doctor of Ministry Projects

Problem

Although the number of Seventh-day Adventist (SDA) volunteers worldwide has increased dramatically, the Church continues to face challenges in engaging people, particularly young adults, in volunteer and mission projects on a global scale. While interest in volunteering is growing, especially in countries within the southern hemisphere, the percentage of participation remains disproportionately small in comparison to the global church membership. Given this disparity, there is a pressing need to research the impact of the volunteer experience on spiritual practices and discipline. Understanding how volunteering influences young adults’ spiritual growth is critical to developing strategies that can effectively engage more …

Evaluating Annual Precipitation Extremes In The Us Great Plains Using Prism Data, Sumiaya Amin Preota, Gaurav Talukdar, Sam Zipper

School of Earth, Environmental, & Marine Sciences Faculty Publications

Understanding hydroclimatic extremes in the U.S. Great Plains (USGP) is crucial for effective water resource management, resiliency of agricultural systems, and mitigation of climate change impacts. This study examines changing hydroclimatic conditions in the USGP, with a focus on annual-resolution precipitation trends and extremes over the past 119 years (1904–2022) using precipitation data from the gridded PRISM climate dataset. We categorized annual-scale precipitation totals into six categories of hydroclimatic extremes: (1) isolated wet extremes, (2) isolated dry extremes, (3) dry-to-dry recurring extremes, (4) wet-to-wet recurring extremes, (5) dry-to-wet whiplash extremes, and (6) wet-to-dry whiplash extremes. “Recurring” and “whiplash” are both …

Nesting Population Trend Of The Leatherback Sea Turtle In Bocas Del Toro Province And Comarca Ngäbe-Buglé, Panama For The Period 2002–2022, Sonia Gutiérrez Parejo, Susan E. Piacenza, Raúl García, Cristina Ordóñez, Roldán A. Valverde

School of Earth, Environmental, & Marine Sciences Faculty Publications

Sea turtle biologists have made sustained efforts to understand the global status of leatherback sea turtle populations. However, despite progress in assessments, demographics, and ecology, key uncertainties persist in tracking leatherback population trends. Trend analyses have historically focused on nesting beaches, with nest counts providing a widely used index for population abundance. Here, we analysed 20 years of annual nest abundance at four main nesting beaches (Soropta, Bluff, Playa Larga and Chiriquí) in Bocas del Toro province and the Comarca Ngäbe-Buglé, Panama, which constitute the largest nesting leatherback sea turtle population in Central America. We conducted daily nest counts during …

Dataset On Indoor And Outdoor Pm2.5 Concentrations At Two Residences Using Low-Cost Sensors In The Rio Grande Valley Region Of South Texas, Kabir Bahadur Shah, Sai Deepak Pinakana, Mkhitar A. Hobosyan, Armando Montes, Amit U. Raysoni

School of Earth, Environmental, & Marine Sciences Faculty Publications

Fine particulate matter (PM2.5) is one of the criteria air pollutants associated with adverse respiratory and cardiovascular health effects. This dataset contains hourly and daily averaged measurements of PM2.5 concentrations (µg/m3) collected from two residential homes in the Rio Grande Valley (RGV) Region of South Texas, using PurpleAir-II-SD low-cost sensor. In addition, the dataset also includes temperature (ºC) and relative humidity (%) measured by the sensors. The data was collected for one month during the summer season from indoor (kitchen) and outdoor (front yard) environments at two locations: Home-1 in Weslaco City from June 16, 2024, to July 16, 2024, …

Exosomes: Historical Evolution And Emerging Roles In Dermatology, Nina Schur, Luna Samman, Milaan Shah, Victoria Dukharan, Carol Stegura, Luke Broughton, Todd Schlesinger

GME Publications

Background: Exosomes are a nanoscale extracellular vesicles derived from different cell types that have been investigated for various clinical applications, including functioning as biomarkers and use as direct therapeutics. Given the role of exosomes in multiple pathophysiologic pathways and potential practical applications, they have garnered significant interest in the scientific community but much is still unknown about their development and use.

Aims: This literature review covers the background, mechanisms of action, use as biomarkers, methods of application, and direct therapeutic applications of exosomes.

Methods: A literature review on the background and uses of exosomes was conducted. Key articles describing the …

A Strategy To Address Youth Homelessness In The Minneapolis Metro Area For The Southview Seventh-Day Adventist Church, Sean Lee

Doctor of Ministry Projects

Problem

The Seventh-day Adventist Church’s teaching on serving a vulnerable neighbor is a crucial foundation of the identity of church members as the disciples of Jesus. Therefore, each congregation needs to be aware of the needs of the community it serves. Furthermore, it is crucial to identify vulnerable neighbors and develop targeted strategies to address their specific needs and issues. According to government reports and media coverage on the issue of youth homelessness in the Minneapolis and St. Paul metro area, youth homelessness is an existing issue, even though resources are invested to address it. Moreover, research shows that the …

The Mordecai-Esther Mentorship Initiative: A Cross-Gender Mentorship Model For Commissioned Female Pastors In South Central Conference, Latina Carriger

Doctor of Ministry Projects

Problem

In the South Central Conference of Seventh-day Adventists (SCC), while male pastors receive formal mentorship through the ministerial internship program leading up to ordination, female pastors—who are only commissioned and not ordained—often experience a lack of continued mentorship beyond commissioning. This absence hinders their professional development, limits leadership opportunities, and contributes to feelings of isolation. The current mentorship framework does not adequately support the ongoing growth of female pastors in a context where ordination is not extended to women, thereby creating a gap in pastoral leadership development and equity.

Method

This project utilized a qualitative case study design to …

The Interchangeable-Part Structure Of Food And Drug Law, Adam I. Muchmore

FIU Law Review

This Article demonstrates that nested tiers of interchangeable parts serve as the foundation for the regulatory programs administered by the U.S. Food and Drug Administration. Core interchangeable parts used in FDA-administered programs include product categories, prohibitions on adulteration and misbranding, agency-registration requirements, current good manufacturing practices, product standards, marketing authorization requirements, postmarket requirements, and user fees. In each of these areas, Congress or the FDA has engaged in interchangeable-part lawmaking (IPL). IPL occurs when a government takes a portion of its law in one subject area and uses it as a model for its own law in another subject area. …

Agents In A Tangled Bank: An Ecosystem Approach To Ai Regulation, Andrew W. Torrance, Bill Tomlinson

FIU Law Review

As autonomous artificial intelligence agents ("Agents") become increasingly prevalent in society, legal frameworks must evolve to govern their behavior effectively. This article argues that autonomous AI agents must be understood as operating within complex ecosystems of other agents, humans, institutions, and actual biological ecosystems-similar to how biological organisms exist within broader ecosystems. Drawing on established research in multi-agent systems and environmental law, we propose that effective governance of AI agents requires moving beyond just regulation on individual agents to include system-level approaches. We examine how existing legal frameworks handle heterogeneous autonomous entities (humans, corporations, and animals) and explore how these …

Being Pregnant In Someone Else's Body, Jennifer S. Hendricks

FIU Law Review

In the wake of the Dobbs decision overturning the right to abortion, now is a critical time to re-assess how legal feminism theorizes the pregnant body. Before Dobbs, feminist legal scholarship had blazed a path of anti-maternalism, a stance rooted in liberal, formalist notions of equality that denigrates the “feminine” and too often minimizes the importance of reproductive issues both as tools of sex-based subordination in the present and as foundations for liberation in the future. Anti-maternalism is attractive to legal scholars because it minimizes sex and gender differences and may appear to be gender-inclusive. It has produced arguments that …

Nevada’S Blockchain Gamble: Can A State Embracing Web3 Technology Lead Probate Courts Into The Digital Age?, Ariel Sweeney

FIU Law Review

Probate stands as a bastion of legal formalism, seemingly resistant to the transformative currents of digital innovation that have swept through other domains of American law. While financial transactions, real property conveyances, and contract execution have increasingly begun exploring the use of Web3 technologies such as blockchain and smart contracts, estate and probate law remain tethered to paper-based procedures and rigid execution requirements. Nevada was the first state to provide legal support for Web3 technology, amending its Uniform Electronic Transactions Act statutes in 2017 to recognize blockchain-based transactions as valid and judicially enforceable. Yet despite this progressive legislative framework, the …