Digital Commons Network^™

Microglial Trem2 Promotes Phagocytic Clearance Of Damaged Neurons After Status Epilepticus, Dale B Bosco, Vaclav Kremen, Koichiro Haruwaka, Shunyi Zhao, Lingxiao Wang, Blake A Ebner, Jiaying Zheng, Manling Xie, Aastha Dheer, Jadyn F Perry, Abhijeet Barath, Aivi T Nguyen, Gregory A Worrell, Long-Jun Wu

The Brown Foundation: Institute of Molecular Medicine

In the central nervous system, triggering receptor expressed on myeloid cells 2 (TREM2) is exclusively expressed by microglia and is critical for microglial proliferation, migration, and phagocytosis. Microglial TREM2 plays an important role in neurodegenerative diseases, such as Alzheimer's disease and amyotrophic lateral sclerosis. However, little is known about how TREM2 affects microglial function within epileptogenesis. To investigate this, we utilized male TREM2 knockout (KO) mice within the intra-amygdala kainic acid seizure model. Electroencephalographic analysis, immunocytochemistry, and RNA sequencing revealed that TREM2 deficiency significantly promoted seizure-induced pathology. We found that TREM2 KO increased both the severity of acute status epilepticus …

Menstrual Cycle Phase Effects On Exercise Thermoregulation And Performance In The Heat, Kailei J. Eustis

All Master's Theses

Hormone fluctuations across the menstrual cycle (MC) may influence physiological responses. This study examined whether thermoregulatory measures differ across MC phases, and if these changes impact running performance in the heat. Ten eumenorrheic adults completed two treadmill runs in simulated conditions (wet bulb globe temperature 31.7 ± 1.4°C) during early follicular (EF) and midluteal (ML) phases. First 45min was a constant self-selected light pace followed by a 15min performance test for distance. Core temperature (Tc), mean skin temperature (Ts), heart rate (HR), perceived exertion (RPE), thermal perception (THERM), and comfort perception (COMF) were assessed every 5min. Sweat perception (SP), sweat …

A Comparative Study Of Legacy And Modern Proton Therapy Pencil Beam Gantries In Prostate Cancer Treatment: Advancements In Efficiency And Performance, Mey Chou, Caitlin Fung, Shaun Ray, Yuting Li, Cameron Tharp, Shaun T. Caldwell

Research Methods Poster Session 2025

No abstract provided.

Autonomous Mower Pilot Project, John T. Evans, Greg M. Shaver, Michael A. Mardikes, Nathan C. Sprauge, Timothy J. Wiegman, Shreyas Supe, Ethan M. Brown

JTRP Technical Reports

The Indiana Department of Transportation (INDOT) spends approximately $19 million annually on roadside mowing, which is a process that is time-consuming, costly, and poses safety risks. Automated mowing solutions have the potential to reduce costs and increase safety, but they will need to be extremely well tested before being deployed. In this work, data from current mowing practices was collected using machine mounted cameras, which was used to inform the creation of a digital twin environment that allows for rigorous initial testing of potential autonomous solution with no risk. The digital twin was created using digital elevation models of Indiana …

Automated Record Keeping For Maintenance Operations Via Tracking Of Maintenance Vehicles Using Telematics Tracks, Anugunj Naman, Yaguang Zhang, Aaron Ault, James V. Krogmeier

JTRP Technical Reports

Efficient and accurate record-keeping for maintenance vehicle operations is essential for optimizing resources, improving accountability, and enhancing decision-making for transportation agencies. The Indiana Department of Transportation (INDOT) sought an automated system to verify and improve work order records using telematics-based vehicle tracking. This study developed and evaluated a system that leverages GPS data from INDOT’s Data Warehouse to automate work order verification, track vehicle movements, and enhance data accuracy for winter highway maintenance operations.

The system integrates GPS tracking, automated data processing, and visualization tools to address key challenges such as data standardization, GPS accuracy, and time resolution. Results indicate …

Separating The Impacts Of A Corrosion Inhibitor From Copper Corrosion Products On Antibiotic Resistance In Drinking Water, Veronika Folvarska, Maya Adelgren, Emily Lou Lamartina, Ryan J. Newton, Yin Wang, Patrick J. Mcnamara

Civil and Environmental Engineering Faculty Research and Publications

Antibiotic resistance is a growing threat to public health, and environmental factors, including metals in drinking water distribution systems, are increasingly recognized as contributors to the spread of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs). Zinc orthophosphate, a common corrosion inhibitor, and copper corrosion products (CuO and Cu₂O) are frequently present in drinking water systems. While each has been shown to increase ARB and ARGs individually, their combined effects remain unknown. The objective of this study was to evaluate the combined impact of copper corrosion products and the corrosion inhibitor zinc orthophosphate on antibiotic resistance. Two …

Characterization Of Fungal Carbonyl Sulfide Hydrolase Belonging To Clade D Β-Carbonic Anhydrase, Ryuka Iizuka, Takahiro Ogawa, Rikako Tsukida, Keiichi Noguchi, David Hibbett, Yoko Katayama, Makoto Yoshida

Biology

Carbonyl sulfide hydrolase (COSase) is a unique enzyme that exhibits high activity towards carbonyl sulfide (COS) but low carbonic anhydrase (CA) activity, despite belonging to the CA family. COSase was initially identified in a sulfur-oxidizing bacterium and later discovered in the ascomycete Trichoderma harzianum strain THIF08. The COSase from T. harzianum has been recognized as a key enzyme in the assimilation of gaseous COS, and homologous genes are widely present not only in Ascomycota but also in Basidiomycota. Here, we characterized the COSases from the basidiomycete Gloeophyllum trabeum NBRC 6430 and T. harzianum to obtain detailed characteristics of fungal COSase. …

Two Coacting Shadow Enhancers Regulate Twin Of Eyeless Expression During Early Drosophila Development, Jacqueline Dresch, Luke L. Nourie, Regan D. Conrad, Lindsay T. Carlson, Elizabeth I. Tchantouridze, Biruck Tesfaye, Eleanor Verhagen, Mahima Gupta, Diego Borges-Rivera, Rob Drewell

Biology

The Drosophila PAX6 homolog twin of eyeless (toy) sits at the pinnacle of the genetic pathway controlling eye development, the retinal determination network. Expression of toy in the embryo is first detectable at cellular blastoderm stage 5 in an anterior–dorsal band in the presumptive procephalic neuroectoderm, which gives rise to the primordia of the visual system and brain. Although several maternal and gap transcription factors that generate positional information in the embryo have been implicated in controlling toy, the regulation of toy expression in the early embryo is currently not well characterized. In this study, we adopt an integrated experimental …

If You Build It: Using Ground Squirrel Risk Perception To Test Wildlife Crossing Structure Success, Sarah Sanz

All Master's Theses

Roads and traffic present many risks for wildlife, and animals must be able to accurately assess risks in their environment. Animals can often perceive the level of risk they face, and their behavioral responses can alter their fitness and potentially even whole-population dynamics. However, animals may be unable to properly measure the levels of risk near roadways because roads present novel environmental conditions and alter predators’ behavior. To mitigate some of the ecological problems created by roadways, wildlife crossing structures (WCSs) are being incorporated into transportation projects. To understand whether WCSs provide quality habitat for wildlife, we compared the levels …

University Of Richmond Magazine - Spring 2025

University of Richmond Magazine

The University of Richmond's Alumni Magazine was first published as The Alumni Bulletin in 1936 and continues to this day as the University of Richmond Magazine.

“No One Told You Life Was Gonna Be This Way”: A Qualitative Exploration Of Friendship Expectations And Reality In University Life, Michael Priestley, Hannah Rachael Slack, Miss Madiha Islam, Delia Fuhrmann, Emily Long, Sarah Crook, Juliet Foster, Sophie Homer, Nicola Byrom

School of Psychology

Introduction: Young adulthood (ages 18–25) is a high-risk period for loneliness, particularly during educational transitions. Loneliness has negative consequences for mental health, physical health, and educational achievement. Psychologists conceptualize loneliness as emerging from a discrepancy between expected and experienced social connection, but this has been under-explored during young adulthood. Method: Drawing on thematic analysis of eight focus groups with 21 young adults in the UK, this paper explores the differences between retrospective expectations and experience of social connection during the transition into university and the implications for loneliness. Results: Whilst social expectations, experiences, and preferences vary considerably, young adults' perception …

On Parentage, Genetics, And Surrogacy, Jessica Tueller

Georgia Law Review

Bans in some jurisdictions, combined with relative affordability in others, have turned surrogacy into an increasingly cross-border phenomenon. Meanwhile, the complex and varied approaches to legal parentage and surrogacy that exist in domestic jurisdictions, along with a lack of international oversight, have at times left children of surrogacy parentless or stateless. The decision of the Hague Conference on Private International Law to begin regulating legal parentage in international surrogacy arrangements is thus an important and welcome development. However, the Hague Conference is considering imposing new genetic requirements that could result in violations of the rights to equality and non-discrimination of …

The New Game Theory, Cortelyou C. Kenney

Georgia Law Review

Game theory and the legal system it models are deeply indebted to the idea of efficiency and efficient outcomes. A great many scholars use game theory to rationalize approaches based on efficiency not only to commercial transactions but also to the legal system writ large, including the tort law system and the criminal justice system.

Efficiency and efficient outcomes have a storied history dating back to Vilfredo Pareto, Ronald Coase, and even before that to Adam Smith. But the person who truly popularized the idea of efficiency was John Nash, who won the Nobel Prize for his work on noncooperative …

Eco-Friendly Synthesis Of Anemonin From 5-Hydroxymethylfurfural, A Biomass-Derived Starting Material, Diane Zefack Tangmi

Theses and Dissertations

Anemonin, a valuable cyclobutane containing dilactone is a bioactive natural product from Ranunculaceae plants. It holds great potential for applications in pharmaceuticals and materials science. However, traditional synthesis methods are hampered by low yields, toxic reagents, and environmental concerns, limiting its practical use. This study highlights the development of green and scalable synthetic strategies designed to achieve high yields while minimizing environmental impact. Our approach focuses on sustainable methodologies, including optimized steam and fractional distillation performed under mild conditions to reduce waste and energy demands. Protoanemonin’s natural ability to dimerize under mild heating offers a green approach to anemonin synthesis, …

Genetic Epidemiology Of Chronic Wasting Disease And Epizootic Hemorrhagic Disease In North Dakota Deer, Ethan S. Baker

Theses and Dissertations

Wildlife diseases have become a critical factor in the management of animal populations across the globe. Such diseases can compromise individual health, reduce population sizes, and disrupt ecosystem biodiversity. As a result, there can be a loss in recreational opportunities which, in turn, can cause economic losses for communities relying on these populations. Effective wildlife disease management not only requires the ability to respond to outbreaks but also the capacity to predict how diseases interact with populations and ecosystems. Due to the complexity of disease dynamics, a multidisciplinary approach is essential for gaining a comprehensive understanding of these systems. In …

Exploring Refugee Students’ Experiences In Midwest Higher Education Environments: Culturally Responsive Practices For Educators, Rohana De Silva

Theses and Dissertations

This qualitative study examined the teaching and learning strategies used by highereducation faculty to support refugee students at a Midwestern university. Recognizing that refugee students bring diverse cultural, linguistic, and experiential backgrounds to academic environments, this research examined how instructional practices can either promote or hinder their educational success. Traditional teaching methods often fall short in addressing the complex needs of this student population. Using Yosso’s Community Cultural Wealth Framework, Bourdieu’s Theory of Cultural Capital, and Resilience Theory, this study analyzed the narratives of refugee students to uncover how their lived experiences influenced their educational journeys. Findings revealed that refugee …

Stem Professors’ Motivation To Engage In A College Teaching Certificate, Justin Craig Alexander

Theses and Dissertations

Despite an expanded focus on educating students in STEM disciplines, nearly half of U.S. college students who enroll in these degree programs fail to graduate (Hamm et al., 2020, p. 623). Critics sometimes blame pedagogically untrained faculty (e.g., Kahn, 2022). This Dissertation in Practice (DiP) focused on STEM university faculty's motivation for teaching and whether professors are motivated to enroll in pedagogy courses. Via the lens of self-determination theory (SDT), this DiP examined to what extent STEM faculty at a major research university in the upper Midwest could devote additional time to pedagogy by enrolling in a college teaching graduate …

Impact Of Resin Grinding On Per- And Polyfluoroalkyl Substance Adsorption In Rapid Small-Scale Column Tests, Tihitna Gezahegn Mulugeta

Theses and Dissertations

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with significant health risks. Among the different technologies for PFAS removal, adsorption is preferable due to low-cost, operational simplicity, and use of regenerable adsorbents. While pilot-scale fixed-bed columns are ideal for evaluating adsorption media, they are time- and resource-intensive. Rapid Small-Scale Column Tests (RSSCTs) offer a practical alternative, yet most studies have focused on granular activated carbon, with limited insight into ion exchange (IX) resins. Due to limited literature on the effect resin preparation on the performance of RSSCTs and their prediction accuracies are unexplored. This study investigates the effect of …

Mindfulness And Modification Therapy (Mmt) Group Feasibility And Acceptability Among Prison Residents With Dysregulated Behaviors, Leslie Unger

Theses and Dissertations

Mindfulness and Modification Therapy (MMT; Wupperman, 2019) is a transdiagnostic therapy that systematically integrates aspects of six empirically supported treatments for impulsive and dysregulated behavior. As such, MMT may offer an efficient approach to addressing a variety of dysregulated behaviors, thereby supporting increased safety within carceral settings and enhancing goals of rehabilitation. To date, MMT has demonstrated positive results in community settings when treating substance misuse and anger/aggression, but it has not yet been examined in a prison setting. The present research examines the feasibility and acceptability of using a 14-session version of group MMT as a voluntary treatment option …

Which University Faculty Are Successful Researchers? Developing And Testing Measures Of Research Competence To Predict Faculty Research Motivation And Success, Muhammad Salahuddin

Theses and Dissertations

University faculty play a pivotal role in producing research that leads to positive social change through the creation of new knowledge, enhancement of higher education quality, and improved university rankings. Faculty produce more when they feel competent, autonomously motivated, and acknowledged. Past studies have measured faculty research competencies using self-report scales that may contain biases, potentially leading to significant discrepancies in research outcomes. My program of research – a three-article dissertation – aimed to develop and validate the test-based measures of faculty research competence that can more reliably predict faculty research success. The three studies provide an enhanced understanding of …

Precipitation Forecast And Verification For Suas Applications, Patrick Britt

Theses and Dissertations

Small Unmanned Aerial Systems (sUAS) have become a fast-growing part of air traffic in the United States. This significant growth is due to the numerous uses these systems can provide, both recreationally and professionally. Due to the small nature of the sUAS, any weather, regardless of intensity, plays a vital role in flight operations and planning. In a survey of sUAS pilots, it was found that precipitation was the most significant hazard of concern, and the most time-sensitive hazard, as precipitation conditions are most often checked by operators in the immediate moments before flight. This project aimed to create, analyze, …

Computational Prediction Of Hemolysis In Laminar Non-Newtonian Fluid, Nasim Gholizadeh

Theses and Dissertations

Hemolysis, the rupture of red blood cells (RBCs), is a critical concern in blood-circulating devices, requiring accurate predictions to ensure patient safety. This study investigates the sensitivity of hemolysis predictions to variations in viscosity models and hemolysis coefficients under complex flow conditions. Computational Fluid Dynamics (CFD) simulations were conducted using Ansys Fluent and OpenFoam on identical meshes with the FDA benchmark nozzle model. Under laminar flow conditions, CFD frameworks accurately predicted global variables, but variations in derived quantities, such as strain rate and vorticity, emerged due to differences in numerical solvers and gradient evaluation methods. These variations affected predictions of …

The Effect Of Metallothionein-3 On Global Gene Expression And Transcriptome Of Kidney Progenitor And Urothelial Cells, Julia Kochanowski

Theses and Dissertations

Metallothioneins (MT) are low molecular weight, cysteine-rich, metal-binding proteins that protect against metal toxicity. MTs have several functions, such as transport of metals, detoxification of metals, and protection from metal toxicity. MT-3, first called growth inhibitory factor, was originally discovered as the Alzheimer’s disease gene. MT-3 has a unique structure with 7 additional amino acids. The role of MT-3 is unknown. Some studies suggest MT-3 plays a role in the immune system and with cisplatin resistance. RPTEC/TERT1 cell line is an immortalized cell line from the human proximal tubule of an adult kidney. It was determined that RPTEC/TERT1 cultures consisted …

Investigating The Role Of Keratin 6 And Sox2 In Regulating Growth, Stemness, Basal/Squamous Expression, And Chemotherapy Response In Muscle-Invasive Urothelial Carcinoma, Nelofar Nargis

Theses and Dissertations

Urothelial carcinoma (UC) is a prevalent and aggressive malignancy arising in urothelial cells, with arsenic exposure recognized as a significant environmental risk factor. It is categorized into two primary subtypes based on the extent of cancer progression beyond the bladder’s muscle wall: non-muscle-invasive urothelial carcinoma (NMIUC) and muscle-invasive urothelial carcinoma (MIUC). While NMIUC is associated with a relatively favorable prognosis, progression to MIUC is more aggressive and leads to significantly worse outcomes, including poor treatment response and increased metastasis. Squamous differentiation (SD) in UC is an emerging hallmark of aggressive UC, with patients often having poor prognoses and developing chemoresistance, …

From Emily To Loralei To Rory: A Qualitative Textual Analysis Of Scripts From Gilmore Girls For Real-World Application, Erin Mccann

Theses and Dissertations

In the realm of interpersonal communication and intrafamilial research, one dynamic, the mother and daughter pairing, is especially poignant in exploring the ties of closeness, the openness of communication and the potential for long-term impact on a daughter’s development. When studying the mother and daughter dynamic through a work of fiction, patterns can be observed without bias, allowing for evaluation of the strength of relationship and identification of broader implication to the discipline of family communication. In this study, a textual analysis was conducted evaluating 21 exemplary episodes of the 2000s television show Gilmore Girls focused entirely on the interactions …

Addressing The Impact Of Unlicensed And Under-Licensed Teachers In Pk-12 Schools: How School Administrators Offer Support, Taylor Topinka

Theses and Dissertations

As the impact of the teacher shortage grows, more teachers are entering classrooms with incomplete teacher licensure. Related literature affirms that new-to-profession teachers experience what Danielson (1999) described as a “sink or swim in the deep end of the pool” culture as they attempt to navigate the beginning of their teaching career with an incomplete license or no license entirely (p. 251). The influx of partially-licensed teachers engaging students is a dilemma created by the growth of the teacher shortage. The purpose of this study was to address the impact of unlicensed and under-licensed teachers on student growth and achievement …

Spatial And Temporal Assessment Of Meteorological Drought Using The Standardized Precipitation Index (Spi) And Its Effect On Crop Yield Over The Corn Belt Region Of The United States From 2000 To 2023, Victor Araya

Theses and Dissertations

Climate change and global warming have contributed to extreme weather events and patterns, including severe flooding, earthquakes, wildfires, and drought. Drought happens to be the deadliest catastrophic event around the world. Drought's impact on ecosystems and local communities has been increasing in many parts of the world, including the United States and, most importantly, the corn Belt, which also happens to be the country's food basket. Understanding drought prediction and mitigation can be investigated through drought indices. The Standardized Precipitation Index (SPI) is considered the most reliable in this study. It is used in this study to present the critical …

Gender And Family Differences In Faculty Motivation, Allyssa Jean Baumbach

Theses and Dissertations

This three-article dissertation examines gender and family differences in faculty motivation. Faculty motivation has primarily been studied in the context of development but has only recently begun to focus on productivity and success. Further, studies of faculty motivation do not provide in depth analysis of gender and family differences. Therefore, the current program of research uses the Self-Determination Theory to examine gender and family differences in faculty motivation and considers how traditional gender norms may contribute to these differences. The first study explored if gender difference existed. Data from a small sample of faculty (N=118) from two universities in the …

An Explainable Ai Framework For Detecting Harmful Algal Blooms (Habs) In Freshwater Lakes, Meera Gopinath Sujatha

Theses and Dissertations

The increase in economic impacts due to the rapid growth of harmful algal blooms (HABs) in freshwater lakes has prompted the development of monitoring and prediction systems. However, limited target data hinders reliable predictions on HAB formations. To address this limitation, this dissertation focuses on providing solutions through data-driven,interpretable, and explainable machine learning models. In Chapter 3, an interpretable multivariate regression model such as Vector Autoregressive (VAR) was used to analyze the important factors that contribute to the formation of cyanobacteria in lakes. The causality tests performed on multiple water quality data helped to determine Alkalinity, Chlorophyll-a (Chl-a), andWater Temperature …

Teaching Agroecology Through Play: A Board Game On Companion Planting Using Agroecological Principles, Ashmita Das, Julie Capito-Hernandez, Estelí Jiménez-Soto

School of Geosciences Faculty and Staff Publications

Board games themed around environmental topics are promising tools for promoting awareness of complex sustainability issues, as the materiality, sociality, and multidimensionality of gameplay can help overcome some of the inherent limitations of more traditional learning formats. To explore the potential relevance of board games for communicating about agrifood system topics in particular, we designed and tested a game called Companion: An Agroecological Adventure, in which players take on the role of community gardeners who must apply both social and ecological principles of agroecology to cultivate a thriving garden plot. In this paper, we present the results of a study …