Digital Commons Network^™

Establishment And Characterization Of Vincristine-Resistant S1 Colon Cancer Cells, Harsh Patel

Theses and Dissertations

Colorectal cancer (CRC) remains one of the most common causes of cancer-related mortality worldwide. Vincristine is frequently used to treat CRC, although the specific pathways leading to acquired resistance are still not fully understood. In this study, we established two novel vincristine-resistant human colon cell lines (S1/V1 and S1/V4) to explore the mechanisms underlying vincristine resistance, with a particular emphasis on the overexpression of ATP-binding cassette (ABC) transporters. The S1/V1 and S1/V4 sublines were derived by continuously exposing human S1 colon cancer cells to vincristine. An MTT cytotoxicity assay revealed that S1/V1 cells exhibit about 39-fold greater resistance to vincristine …

Biological And Chemical Evaluation Of Amide-Based Cjoc42 Derivatives As Potential Gankyrin-Inhibitors For The Treatment Of Breast, Lung, And Liver Cancer, Benita Britton-George

Theses and Dissertations

Gankyrin is an ankyrin-repeat protein overexpressed in certain cancers and is responsible for cell growth and proliferation. Gankyrin is important to the development of many types of cancer, including breast, lung, and liver cancer. Consequently, gankyrin and its various protein-protein interactions, are prospective therapeutic targets for inhibiting the progression of certain cancers. In 2016, the first small molecule inhibitor of gankyrin, cjoc42, was discovered and subsequently demonstrated modest antiproliferative activity against liver cancer cells. Previous work from our lab demonstrated that replacing the sulfonate ester of cjoc42 with an amide group significantly improved gankyrin binding while enhancing antiproliferative activity against …

The Psychometric Properties Of A Spanish Version Of The Attitudes And Beliefs Scale-2 Short Form In A Mexican Sample, Verónica Compeán

Theses and Dissertations

The Attitudes and Beliefs Scale 2-Short Form (ABS2-SF) is one of the most widely used measures of irrational and rational beliefs central to Rational Emotive Behavior Therapy (REBT). While evidence supports its reliability and validity in English-speaking populations, little is known about its applicability across cultural and linguistic groups. This study investigated the psychometric properties and cultural validity of the Spanish version of the ABS2-SF in a Mexican sample (n = 579) collected from undergraduate students in Tampico, Mexico, and compared them with English-speaking American non-clinical samples (n = 1,167). Using a bifactor multi-group confirmatory factor analysis (MG-CFA), I examined …

Neural Congruency Contrastive Learning Framework Validation Using Artificially Created Eeg Data For Dyslexia Research, Jacqueline M. Torres

Theses and Dissertations

Analysis of electroencephalogram (EEG) recordings in children with dyslexia has been commonly used to explore the neural mechanisms underlying reading disorders. Yet, challenges such as low signal-to-noise ratio (SNR), high inter-subject and inter-trial variability, and the inherently multivariate nature of EEG signals hinder the isolation of neural components elicited during reading diagnostic tests. To mitigate these challenges, the neural-congruency analysis framework was recently proposed, leveraging traditional machine learning optimization methods to incorporate domain knowledge about the congruency of neural responses across participants (i.e., consistent neural responses among proficient readers). However, the application of deep learning techniques, specifically contrastive learning, remains …

Expression And Function Of Floral Symmetry Genes In The Regulation Of Flower Shape In Fedia Graciliflora, Theresa A. Mustacchio

Theses and Dissertations

Shifts between radial symmetry (actinomorphy) and bilateral symmetry (zygomorphy) in flowers have occurred multiple times independently within angiosperms (flowering plants). Evidence across angiosperms indicate the transcription factors RADIALIS (RAD), DIVARICATA (DIV), and CYCLOIDEA (CYC) play a major role in regulating floral symmetry and morphology. The CYC-like genes have been shown to shift their expression dorsally independently in nearly all shifts to bilaterally symmetrical flowers examined. Three core eudicot clades of CYC-like genes have been identified: CYC1, CYC2 and CYC3, with only CYC2 genes being shown to have a role in floral symmetry. We use the non-model plant, Fedia graciliflora (Caprifoliaceae) …

Propelling Whole-Cell Biosensor Creation By Leveraging Gene Fusion To Assemble Synthetic Functional Transcription Factors For The Detection Of Biomarkers, Samuel J. Verzino

Theses and Dissertations

Biosensors are analytical devices that leverage biological modules for the detection of molecules of interest. As customizable tools designed to aid in a wide array of diagnostics, these instruments are rapidly advancing the field of synthetic biology. While varied in their construction and purpose, biosensors are ultimately concerned with converting a physicochemical stimulus into a detectable signal. Among the many existing variants, whole-cell biosensors (WCBs) stand out due to their versatility and engineering potential. WCBs are a type of biosensor in which a physiologically active cell sustains an array of biomolecular elements - receptors, transporters, regulators, etc. - capable of …

As I Type: An Autoethnography Of Italian (Sicilian) Family Literacies Across Generations In The United States, Kailyn Nicole Giaccone

Theses and Dissertations

This dissertation aims to investigate the racialization of my own family through the examination of migration and citizenship documents, primary sources, and oral histories as told by those who were present for or knew those present for events in question. Participants, including myself, were members of the same family, identified as either male or female, and ranged in age from 30 years to 80 years old. Participants were either monolingual English speakers or multilingual in English, Italian, and/or Sicilian. The methodology used to accomplish this research was autoethnography, which allowed the use of traditional database research, archival examinations of primary …

Operation Airlift Africa: American Education And The Development Of Future Leaders From British Colonies In East And Central Africa, David N. Gachigo

Theses and Dissertations

In the late 1950s and early 1960s, over 800 students from British East and Central Africa gained access to American education through Operation Airlift Africa (OAA), a visionary initiative led by Kenyan trade unionist and politician Tom Mboya. Funded by private American donors, including Senator John F. Kennedy, and supported by scholarships from U.S. institutions, the program enabled African students to attend high schools, colleges, and universities in North America, mostly in the United States. This dissertation explores the impact of OAA on educational access for colonial subjects and its role in shaping future African leadership. The study argues that …

Sustained Effects Of Neurofeedback On Children & Adolescents With Adhd: A Meta-Analysis, Dannielle A. Stephen

Theses and Dissertations

Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder diagnosed in the United States, with the most common form of treatment being psychostimulant medication. In the recent years there has been a growing concern among parents about starting their children on medication from a young age, prompting researchers to look at alternative methods. This will me a meta-analytic review of neurofeedback treatments to see if they are a feasible method in improving core behavioral symptoms and executive functions. All articles included in the review contained follow-up periods of 6 months or greater. There was a total of 468 participants across …

Qualitative Analysis Via Network Models Of Human Dynamin-1 Throughout Gtp Hydrolysis, Kevin Brian Schulman

Theses and Dissertations

This thesis aims to elucidate the molecular mechanisms by which nucleotide binding dictates the intrinsic dynamics and to understand the functional conformational changes of Human Dynamin-1 during the GTP hydrolysis cycle through the use of Elastic Network Models (ENM). A comprehensive understanding of this process is crucial given dynamin's role in clathrin-mediated endocytosis (CME). The research utilized both experimentally derived crystal structures and AlphaFold-predicted structures of dynamin, specifically examining the GTPase and Bundle Signaling Element (BSE) domains across nucleotide-free, GTP-bound, GDP-bound, and transition states. The essential features of the research methodology involved a multi-scale computational approach. Qualitative analyses were performed …

Sonic Futures: Exploring Podcasting, Artificial Intelligence, And The Evolving Landscape Of Composition, Grant David Crawford

Theses and Dissertations

This dissertation investigates podcasting and audio projects as multimodal practices in composition, analyzing how audio-based assignments both challenge and reproduce traditional writing norms. Drawing from personal teaching experience and a dataset of publicly accessible assignment prompts, rubrics, and instructional guides, the study examines how podcast projects are framed, assessed, and implemented in higher education. While often promoted as creative and accessible alternatives to essays, these assignments frequently replicate the same thesis-driven, rubric-centered, and exclusionary structures that define conventional academic writing. Through a cross-textual analysis of fifteen podcast rubrics and fifteen assignment prompts, this project identifies recurring patterns, including paradoxical expectations …

Nutrition Assessment Of Substance Use Population Compared To Control Population, Lalitha Indrani Dasari

Theses, Dissertations and Capstones

This study aims to evaluate and compare the nutritional status of individuals undergoing treatment for substance use disorder (SUD) with a matched control population. Poor nutrition, micronutrient deficiencies and malabsorption are common in individuals with SUD, potentially affecting recovery outcomes. This study involves collection of biometric data, demographic information, conducting a structured nutrition survey and performing a one-time blood draw of 35ml to assess key nutritional markers such as lipid panel, folic acid, vitamin B12, vitamin D, thyroid stimulating hormone (TSH), magnesium, selenium, chromium, zinc, copper and lithium. While the original protocol was designed to recruit approximately 110 participants across …

Analysis Of The Influence Of Telomere Length Variation On Flowering Time And Plant Fitness In Arabidopsis, Brianna Spadavecchia

Theses, Dissertations and Capstones

Telomeres are conserved structures at the ends of eukaryotic chromosomes that promote genome stability. In most eukaryotes, the DNA found within these protective end caps consists of short, G-rich nucleotide repeats. Cells with critically short telomeres face a variety of potential adverse outcomes such as end-to-end chromosome fusion, apoptosis, etc. The length of telomeric DNA varies substantially between different plant species and even between genotypes of the same species. A previous study using T-DNA mutants of the model plant Arabidopsis thaliana with long or short telomeres suggested that telomere length may be an adaptive trait. Specifically, for reproductive fitness, the …

Winter 2025, Augustana College, Rock Island Illinois

Augustana Magazine

No abstract provided.

Species-Specific Discrimination Of Bacterial Biofilms Using A Ratiometric Fluorescence Sensor Array And Machine Learning, Ritika Gupta, Aayushi Laliwala, Elena Muldiiarova, Kenneth W. Bayles, Denis Svechkarev, Marat Sadykov, Aaron M. Mohs

Journal Articles: Pathology and Microbiology

Biofilms are intricate bacterial communities encased in a self-produced extracellular matrix (ECM) of DNA, lipids, proteins, and polysaccharides. The diverse ECM composition across bacterial species significantly influences the progression of biofilm-associated infections, making precise identification crucial for effective treatment. Traditional methods such as biochemical assays, MALDI-TOF mass spectrometry, DNA sequencing and culturing provide valuable insights but have notable drawbacks, including time-consuming procedures, high costs, and the need for specialized equipment and trained personnel. These limitations hinder the rapid and widespread adoption of biofilm identification in clinical settings, underscoring the need for more streamlined, accurate, and accessible methods. In this study, …

Assessing The Impact Of Key Environmental Factors On Caretta Caretta Nesting Patterns In Sarasota County, Matthew Senecal

Theses & ETDs

Environmental factors can impact development for oviparous species during incubation. For sea turtles temperature can influence the sex ratio of the hatchlings and can decrease survival. The substrate the eggs are incubated in can differ between nests thus, impacting nests differently. This study examines the impact of sand characteristics, specifically grain size, color, calcium carbonate, change in sand surface temperature, and hydraulic conductivity, on overall nest viability in Sarasota County, Florida. Darker sands, such as those found further to the south, may lead to higher incubation temperatures and faster hatching rates, potentially increasing the proportion of female hatchlings. Laboratory analysis …

The Queen’S Gambit, Jennifer Stegman

Theses & ETDs

The Queen’s Gambit by Walter Tevis is both a novel and a Netflix mini series about a female chess prodigy, Beth Harmon, navigating the world of chess in the mid-twentieth century. The adaptation to screen in 2020 sparked a global interest in chess, especially among women. My thesis analyzes the adaptation from novel to series, the use of music as a narrative tool, the historical context, the chess games themselves, and the character development. I will be integrating my personal experience as a female chess player, and focusing on how my evolution and experience as a player mirrors Beth’s. I …

Applications Of Marine Optics: Satellite-Derived Bathymetry, Light Attenuation Measurements Via Multi-Spectral Light Sensors, And Colored Dissolved Organic Matter Spectral Analysis, Noah Tyler

Theses & ETDs

This thesis aims to explore three applications of the field of marine optics. First, some marine optical principles are applied to satellite imagery to generate satellite-derived bathymetry (SDB) charts for Sarasota Bay, FL. SDB charts were successfully created using satellite images from July and August of 2023. Unique terrain features, such as the intercoastal waterway, can be seen in the SDB charts. Next, a multi-spectral light sensor system (MSLSs) was developed so it could be utilized to measure attenuation as a proxy for turbidity using marine optics concepts. The MSLSs were deployed in Sarasota Bay to collect attenuation data. The …

This Is Gospel; Seven Stories And A Nonfiction Braid (Bacc To Writing, Writing To Bacc; A Short Story Collection), Zena Williams

Theses & ETDs

My thesis for spring of 2025 is a collection of seven short stories and one nonfiction piece. These are pieces I have created over my time here at New College. Each has been redrafted at least three times, and it has been a long process to build this collection that I am so proud of. I hope you enjoy it, but first maybe some context. Coming soon! No clue if this is right or not.

Principles Of Advanced Manufacturing For Engineers, Xin Zhao, Walid Asad, Subha Majumder, Chenyang Zhu

Manufacturing

No abstract provided.

A History Of Individuation: Aristotle, Jung, Simondon And The Vital Impulse, Sam Gould

International Journal of Transpersonal Studies Advance Publication Archive

This paper theoretically situates transformation as a biophysiological process specific to information transfer in and throughout a multicellular organism, conceptualized as the epigenesis, morphogenesis, and formation of the self in the unfolding process of individuation. The self will be ascribed, not merely as the Jungian definition of something to be realized through individuation, but rather, as a twofold operation: (a) As a conjunction within the process of individuation that extends into, as part of, the possible future process of individuation; to account for this phase in the operation of the unfolding of the self, the paper refers to Gilbert Simondon’s …

Undergraduate Catalogue 2025 - 2026, Tennessee State University

Tennessee State University Undergraduate Catalogues

No abstract provided.

Unm Pathology, Pathfinder Winter 2025, Unm Department Of Pathology

Newsletters

No abstract provided.

Reduced Risk Of Necrotizing Enterocolitis With Breastfeeding, Jadyn Tavekelian

The PA Department Journal of Medical Science

Abstract

Introduction: Necrotizing enterocolitis (NEC) is a life-threatening disease in infants that causes direct damage to the intestines and requires emergent treatment. The purpose of this clinical review is to analyze the prevention of NEC in preterm neonates with breastfeeding.

Methods: PubMed was searched using a specific search strategy using the key terms “breast,” “feed,” “formula,” “necrotizing,” and “enterocolitis.” Operators and filters applied narrowed the results to 4 quality articles for review.

Results: One RCT, and two meta-analyses, reviewed had a reduction in the development of necrotizing enterocolitis among breastfed neonates. One randomized noninferiority trial totaling 123 neonates did not …

Efficacy Of Second Generation Antipsychotics As An Adjunct Therapy For Major Depressive Disorder, Gina Russo

The PA Department Journal of Medical Science

INTRODUCTION: Major depressive disorder is a debilitating mental health condition for many US adults. Traditional therapies may not be effective for many patients. The purpose of this paper is to evaluate the effectiveness of brexpiprazole, a second generation antipsychotic medication, as an adjunctive treatment for resistant MDD.

METHODS: PubMed was searched with a specific search strategy using key terms “brexpiprazole” and “major depressive disorder.” This search resulted in 21 results in which four articles were chosen based on the availability of free full text and the included content. Of the articles selected, three were a systemic review and meta-analyses, …

Food Resource Efficiency Decision Support Hub: Workshop 2 - Summary Report, Jennifer Attard, Tracey O'Connor, Simon Patterson, Julia Lessa Feitosa Virgolino, Mina Sadeghzadeh

Publications

FRED is focused on informing policy on food waste prevention using a total food system sustainability approach.

Food Resource Efficiency Decision Support Hub: Workshop 3 - Summary Report, Jennifer Attard, Tracey O'Connor, Simon Patterson, Julia Lessa Feitosa Virgolino, Mina Sadeghzadeh

Publications

FRED is focused on informing policy on food waste prevention using a total food system sustainability approach.

Food Resource Efficiency Decision Support Hub: Workshop 4 - Summary Report, Jennifer Attard, Tracey O'Connor, Simon Patterson, Julia Lessa Feitosa Virgolino, Mina Sadeghzadeh

Publications

FRED is focused on informing policy on food waste prevention using a total food system sustainability approach.

Food Resource Efficiency Decision Support Hub: Workshop 1 - Summary Report, Jennifer Attard, Tracey O'Connor, Simon Patterson, Julia Lessa Feitosa Virgolino, Mina Sadeghzadeh

Publications

FRED is focused on informing policy on food waste prevention using a total food system sustainability approach.

Food Resource Efficiency Decision Support Hub: Food System Stakeholder Needs Identification, Jennifer Attard, Tracey O'Connor, Simon Patterson, Julia Lessa Feitosa Virgolino, Mina Sadeghzadeh

Publications

Understanding the needs of everyone in the food system is vital to solving the food waste problem. If interventions are misaligned with stakeholder needs, the resultant impact will be highly diminished and/or will result in unintended consequences. We there fore conducted significant stakeholder engagement to identify and prioritise stakeholder needs.