Digital Commons Network^™

Peptide-Based Inorganic Nanoparticles As Efficient Intracellular Delivery Systems, Amir Nasrolahi Shirazi, Rajesh Vadlapatla, Ajoy Koomer, Anthony Nguyen, Vian Khoury, Keykavous Parang

Pharmacy Faculty Articles and Research

Background/Objectives: Peptide-based inorganic nanoparticles (PINPs) have emerged as promising candidates for intracellular delivery due to their unique structural and functional attributes. These hybrid nanostructures combine the high surface area and tunable optical/magnetic properties of metal cores (e.g., Au, Ag, Fe3O4) with the biocompatibility, targeting specificity, and responsive behavior of peptides. In particular, peptides with amphipathic or cell-penetrating features could facilitate efficient transport of molecular cargos across cellular membranes while enabling stimulus-responsive drug release in target tissues. Methods: We review key synthesis methods (especially green, peptide-mediated one-pot approaches), functionalization strategies (e.g., thiol-gold bonds, click chemistries), and characterization techniques (TEM, …

Ole Miss Student Combines Passions In Italian Medical Fellowship, Marisa C. Atkinson

University of Mississippi News

OXFORD, Miss. – Sparked by a love of travel and aspirations of becoming a doctor, University of Mississippi junior Samantha Ragan experienced the best of both worlds when she spent time in Italy this summer as part of a global health fellowship program.

Editorial: Endocrine Imbalances Of Mineral Ions And Vitamins In Chronic Disease Pathogenesis, Mor-Li Hartman, Hosam G. Abdelhady, Mohammed S. Razzaque

School of Medicine Publications

No abstract provided.

Geol 64: Planetary Geology - Syllabus, Dara Laczniak

Open Educational Resources

This Open Educational Resources (OER) syllabus is for an introductory planetary geology course that utilizes results from space missions to expose students to the surface features, composition, geological activity, and probable history of the planets, moons, asteroids, and comets of the solar system. It also places space exploration into the context of larger societal issues such as global warming and natural resource availability and addresses topics such as the ethics of space exploration and hazards of space travel. This OER syllabus aims to foster student-centered learning, critical thinking, data analysis and communication skills, and creativity. Assigned readings are compiled into …

Dna Double-Stranded Breaks, A Hallmark Of Aging, Defined At The Nucleotide Resolution, Are Increased And Associated With Transcription In The Cardiac Myocytes In Lmna-Cardiomyopathy, Benjamin Cathcart, Sirisha M Cheedipudi, Leila Rouhi, Zhongming Zhao, Priyatansh Gurha, Ali J Marian

Faculty, Staff and Student Publications

Aims: An intrinsic feature of gene transcription is the formation of DNA superhelices near the transcription bubble, which are resolved upon induction of transient double-stranded breaks (DSBs) by topoisomerases. Unrepaired DSBs are pathogenic as they lead to cell cycle arrest, senescence, inflammation, and organ dysfunction. We posit that DSBs would be more prevalent at the genomic sites that are associated with gene expression. The objectives were to identify and characterize genome-wide DSBs at the nucleotide resolution and determine the association of DSBs with transcription in cardiac myocytes.

Methods and results: We identified the genome-wide DSBs in ∼1 million cardiac myocytes …

Evolving Paradigms In Acute Myeloid Leukemia: Personalized Approaches To Therapy Across Age And Risk Groups, Sumeet Yadav, Utsav Joshi, Guleid Hussein, Mohamed Warsame, Bolun Liu, Abhash Shrestha, Peter Krastev, Hariprasad Reddy Korsapati, Amrit Singh

Student Publications

Acute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by the clonal proliferation of myeloid precursors and rapid progression. Historically consisting of intensive chemotherapy, AML management has evolved significantly due to advances in molecular diagnostics and risk stratification. This review discusses current therapeutic paradigms in AML, emphasizing the growing role of personalized medicine across age and risk groups. For younger, fit patients, intensive regimens such as the "7 + 3" protocol remain the standard, often enhanced by targeted agents like FMS-like tyrosine kinase 3 (FLT3) and IDH inhibitors. Older or unfit individuals benefit from low-intensity treatments such as hypomethylating …

C-C Motif Chemokine Receptor-Like 2 Promotes The Interferon-Γ Signaling Response In Myeloid Neoplasms With Erythroid Differentiation And Mutated Tp53, Nour Sabiha Naji, Sergiu Pasca, Theodora Chatzilygeroudi, Pablo Toledano-Sanz, Joseph Rimando, Yuju An, Yashvi Hemani, Brandy Perkins, Xinghan Zeng, Conover Talbot, Bogdan Paun, Abdulmuez Abdulmalik, Chen Lossos, Tatianna R Boronina, Ilias Sinanidis, Panagiotis Tsakiroglou, Priyanka Fernandes, Christopher Esteb, Alexander J Ambinder, Robert N Cole, Rena Xian, Ivana Gojo, Suman Paul, Mark J Levis, Amy E Dezern, Leo Luznik, Styliani Karanika, Linda S Resar, Richard J Jones, Frederick Bunz, Lukasz Gondek, Marios Arvanitis, Theodoros Karantanos

Faculty, Staff and Students Publications

Patients with myeloid neoplasms with loss-of-function TP53 mutations and erythroid differentiation have poor outcomes, and a better understanding of disease biology is required. Upregulation of interferon-γ (IFN-γ) signaling has been associated with acute myeloid leukemia (AML) progression, selection of TP53 mutated clones and chemotherapy resistance, but its drivers remain unclear. In this study, we found that the surface receptor C-C motif chemokine receptor-like 2 (CCRL2) is overexpressed in AML with erythroid differentiation and TP53 mutations compared to other AML subtypes and healthy hematopoietic cells. CCRL2 knockout (KO) suppressed erythroleukemia growth in vitro and in vivo. Further proteomics and transcriptomics analysis …

An Antioxidant Approach To Ameliorate The Effects Of Radiation And Chemotherapy On Cognition, Raymond Anan Otoo

Theses and Dissertations

Acute Lymphoblastic Leukemia (ALL) is a hematologic malignancy that primarily affects children and young adults. While advancements in treatment—including chemotherapy and cranial irradiation—have significantly improved 5-year survival rates in children to nearly 90%, radiation-induced cognitive impairment (RICI) remains a persistent and debilitating side effect. The brain, particularly the hippocampus, is highly susceptible to radiation-induced oxidative stress and inflammation. In the treatment of ALL, the combined use of chemotherapy and radiotherapy contributes to a heightened oxidative burden, exacerbating the risk of cognitive dysfunction. Although previous studies have linked radiation exposure to neurocognitive decline, the molecular mechanisms underlying RICI and chemotherapy-induced cognitive …

Pressure And Force Dynamics In Artificial Muscle Actuators: A State-Space And Optimization-Based Approach, Mohammad Elzein

Dissertations and Theses

This two-part investigation explores the dynamic behavior of braided pneumatic actuators (BPAs) under bio-inspired pulse modulation, with the aim of improving their biomimetic force output and control. The first study examines the effect of pulse length and inter-pulse timing on BPA performance, revealing that force output is highly sensitive to the temporal structure of input pulses mirroring biological muscle behavior. Using dual-pulse actuation schemes, the results demonstrate that force responses exceed the additive contributions of individual pulses, with peak amplification occurring consistently at a 27 ms inter-pulse gap. Shorter pulse lengths (10–20 ms) yielded the highest normalized force increases, up …

The Social And Political Identities Of Latine Republicans In The U.S., Gabriella M. Mota

Dissertations and Theses

Between the 2016 and 2024 presidential elections, support for Republican candidate Donald Trump among Latine voters increased from 29% to 42%. This rise has attracted interest given Trump's nativist rhetoric and policies that target Latine immigrants. Previous literature has examined the growing Republican partisanship among Latine Americans, focusing on the processes of assimilation and the effects of racial ideology on the partisanship of the Latine electorate. Although this research is gaining traction, the political attitudes of Latine Republicans remain understudied. This study explores how Latine Republicans manipulate ethnoracial attachments to justify their support for Donald Trump and the Republican Party. …

Comprehending Students' Experiences With A Language Learning Resource Center: A Descriptive Phenomenological Study Of College Life And Belonging, Paulina Dzieza

Dissertations

This study explores the impact of Language Learning Resource Center (LLRC) services on college students' overall college experience and their sense of belonging on campus. In the constantly evolving world of higher education, higher education institutions work to provide welcoming spaces where students can flourish academically and socially. In higher education, where there is a growing focus on student support services, the LLRC is essential for promoting academic achievement, cross-cultural interaction, and social integration for foreign language learners. This qualitative study, guided by a combined theoretical framework of Community of Practice and Ethics of Care, aims to advance knowledge of …

The Immunophenotypic And Genetic Characterization Of Pediatric T -L Ymphoblastic Leukemia With A Mature Immunophenotype, Mahsa Khanlari, Wei Wang, Parastou Tizro, Mohammad K Eldomery

Faculty, Staff and Student Publications

Not available.

Alterations In Ether Lipid Metabolism In Obesity Revealed By Systems Genomics Of Multi-Omics Datasets, Yvette Schooneveldt, Sudip Paul, Kevin Huynh, Habtamu B. Beyene, Natalie A. Mellett, Gerald F. Watts, Joseph Hung, Jennie Hui, John Beilby, John Blangero

Human Genetics Publications

Ratios between two metabolites are sensitive indicators of metabolic changes. Lipidomic profiling studies have revealed that plasma ether lipids, a class of glycero- and glycerophospho-lipids with reported health benefits, are negatively associated with obesity. Here, we utilized lipid ratios as surrogate markers of lipid metabolism to explore the processes underlying the inverse relationship between ether lipid metabolism and obesity. Plasma lipidomics data from two independent human cohorts (n = 10,339 and n = 4,492) were integrated to assess the associations between 82 lipid ratios and obesity-related markers in males and females. Results were externally validated using mouse transcriptomics data …

August 28, 2025, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Bi-5756 Reduces Graft-Versus-Host Disease Through Cb1-Mediated Treg Upregulation, Sena Kim, Abdul-Jalil Dania, Sora Lim, Jaebok Choi

2020-Current year OA Pubs

Cannabinoid receptor 1 (CB1) has been implicated in multiple inflammatory diseases by regulating pro-inflammatory mediators or altering immune cell polarization. However, the expression and direct functional role of CB1 in T cells remain largely unexplored. Here, we demonstrate that primary murine T cells express CB1 and that its novel agonist, BI-5756, directly increases the frequencies of regulatory T cells (Tregs) in primary murine pan T cells after activation. In addition, BI-5756 exhibits an in vivo protective effect against graft-versus-host disease (GvHD), an allogeneic T cell-mediated inflammatory complication after allogeneic hematopoietic cell transplantation (allo-HCT), resulting in an improved overall survival with …

Peer-Led Sexual And Reproductive Healtheducation Programs At Universities, Madison Michelle Patrick

Silicon Valley Sociological Review

This applied research explores the accessibility, visibility, and comprehensiveness of sexual and reproductive health (SRH) education and services at universities, with a specific focus on contraceptive risk awareness. Recognizing college students as particularly vulnerable to misinformation regarding hormonal contraceptives, unintended pregnancy, and STI exposure, the study examines the role of university-provided SRH resources in mitigating these risks.

A mixed-methods content analysis was conducted on the SRH publicly-available web pages of four Northern California universities—Stanford University, San Francisco State University, Santa Clara University, and the University of California, Berkeley, chosen for their diversity in institutional identity. The research assessed each university’s …

Association Between Area Deprivation Index And Outcomes After Subarachnoid Hemorrhage, Michelle Chung, Zhirui Deng, Dianxu Ren, Kelly Isola, Elizabeth Crago

Creating Healthy Work Environments (CHWE)

Subarachnoid hemorrhage (SAH) is a life-threatening hemorrhagic stroke caused by bleeding in the arachnoid space of the brain, often resulting in long-term disabilities and poor quality of life (QOL). Individuals living in more advantaged neighborhoods report higher levels of QOL post-stroke, but little has been reported about QOL and neighborhood data after SAH.

This study sought to examine the relationship between measures of socioeconomic status (SES) and outcomes after SAH. SES encompasses a variety of factors. For this analysis, the area deprivation index (ADI) - a measurement of neighborhood socioeconomic disadvantage - was used as a surrogate for SES. We …

Bridging The Gap Of Bipoc Patients, Clinicians, And Doulas, Tasha Chatman

Creating Healthy Work Environments (CHWE)

The project is a Doctor of Nursing practice quality improvement project addressing the barriers to collaboration between BIPOC prenatal patients, clinicians, and doulas. Maternal mortality and morbidity are a crisis in our nation with black women dying three times more than their white counterparts (Harris, n.d.). BIPOC prenatal patients are suffering from maternal mortality and morbidity. Stemming from such as historical racism, racial inequalities, implicit bias and structural determinants of health. The Doula can give cultural congruent care, impower BIPOC prenatal patients, while providing emotional and physical support. The utilization of a doula as continuous labor support is shown to …

Rna Sequencing-Based Transcriptome Analysis Of Liver In Laying Hens Supplemented With Dietary Probiotic Bacillus Species And Prebiotic Yeast (Saccharomyces Cerevisiae) Cell Walls, Ala E. Abudabos, Zafar M. Hakami, Ali R. Al Sulaiman, Riyadh S. Aljumaah, Valentino Palombo, Mashael R. Aljumaah, Mariasilvia D’Andrea, Abdulrahman S. Alharthi, Rashed A. Alhotan

Food and Animal Sciences Faculty Research

To investigate the impacts of dietary Bacillus-based probiotics and yeast-derived prebiotics on the hepatic transcriptome profile, 500 Hisex White laying hens were randomly allotted into five dietary treatments from 37 to 52 weeks of age: control; control + Bacillus subtilis; control + Bacillus subtilis and Bacillus licheniformis; control + Bacillus coagulans; and control + Saccharomyces cerevisiae yeast cell wall. Transcriptome analysis revealed a substantial number of differentially expressed genes exclusively between the control and prebiotic groups, identifying 2221 genes (FDR ≤ 0.05), with 980 genes upregulated (log2 fold change 0.69 to 24.62) and 1241 downregulated (log2 fold change −0.74 to …

Commonwealth Times 2025-08-27

Commonwealth Times, 1969-

No abstract provided.

Accelerating The Fusion Workforce In The Usa, Carlos Paz-Soldan, Eva Belonohy, Troy Carter, Laleh E. Coté, Evdokiya Kostadinova, Calvin Lowe, Subash L. Sharma, Sybil De Clark, Jaydeep Deshpande, Kate Kelly, Bobbi Makani, David A. Schaffner, Kathreen E. Thome

Faculty Research, Scholarly, and Creative Activity

The fusion energy research and development landscape has seen significant advances in recent years, with important scientific and technological breakthroughs and a rapid rise of investment in the private sector. The workforce needs of the nascent fusion industry are growing at a rate that academic workforce development programs are not currently able to match. This paper presents the findings of the Workforce Accelerator for Fusion Energy Development Conference held in Hampton, Virginia, United States of America (USA), on 29-30 May 2024, which was funded by the National Science Foundation of the USA. A major goal of the conference was to …

Lip Tie Management And Treatment, Bob Underwood, Jairrah Godsil

Pediatrics in Practice: A CME Podcast

In this episode, we’re joined by Jairrah Godsil, Occupational Therapist at Children’s Mercy, to explore the often misunderstood topic of lip ties in infants. Jairrah shares how lip ties can impact feeding, oral motor development, and long-term function—and what pediatricians should look for during early assessments. We’ll also discuss the importance of a multidisciplinary approach, the role of occupational therapy in treatment, and how to navigate the balance between anatomical structure and functional impact. Whether you’re seeing infants in your clinic or collaborating with feeding specialists, this conversation offers practical insights you won’t want to miss.

Click here to stream …

The Illusion Of Internal Models In Biological Movement, Madhur Mangalam

Journal Articles

The concept of internal models dominates contemporary theories of sensorimotor control, with researchers across neurosciences, specifically motor control, routinely explaining observed behaviors through computational representations that supposedly exist within the nervous system. In this perspective, I present a critical examination of internal model frameworks in sensorimotor control. I argue that representational approaches mischaracterize biological systems for several fundamental reasons: (1) Internal models require homuncular interpreters, creating infinite regress problems; (2) The purported neural implementations of internal models remain empirically elusive despite decades of research; (3) Biological movement systems exhibit multiscale, nonlinear, and non-Gaussian dynamics that fundamentally defy reduction to conventional …

Class Of 2029 Officially Joins The Ole Miss Family, Marisa C. Atkinson

University of Mississippi News

OXFORD, Miss. – The Class of 2029 officially celebrated the start of their journey at the University of Mississippi during Tuesday's (Aug. 26) Fall Convocation at the Sandy and John Black Pavilion at Ole Miss.

Nf1-Depleted Er+ Breast Cancers Are Differentially Sensitive To Cdk4/6 Inhibitors, Ze-Yi Zheng, Anran Chen, Eric J Jaehnig, Meenakshi Anurag, Jonathan T Lei, Long Feng, Chenwei Wang, Diana Fandino, Purba Singh, Hilda Kennedy, Ghazal Yadav, Craig T Vollert, Jill Tsai, Xi Chen, Yi Li, Bora Lim, Alastair Thompson, Shunqiang Li, Charles E Foulds, Bing Zhang, Matthew J Ellis, Eric C Chang

Faculty, Staff and Students Publications

Neurofibromin/NF1 is a RAS (rat sarcoma virus) GTPase activating protein and estrogen receptor (ER) transcriptional corepressor. NF1low status, identified by copy number loss or low mRNA/protein expression is associated with endocrine therapy resistance in approximately 20% of ER+/HER2− (human epidermal growth factor receptor 2) early-stage breast cancers. The identification of targeted treatments for NF1low ER+/HER2− breast cancer is therefore a priority. In this study proteogenomic analysis of ER+/HER2− breast cancer demonstrated that NF1low tumors exhibited elevated cyclin-dependent kinase 4/6 (CDK4/6) activity. In cell lines, NF1-deletion had a dual effect on CDK4 activity. First, by promoting ER recruitment to CCND1 …

Optimizing Pharmacologic Treatment For Neonatal Opioid Withdrawal Syndrome (Optimize Now): A Symptom-Based Dosing Approach Study Protocol For A Multi-Center, Cluster Crossover Design Randomized Controlled Trial, Leslie W. Young, Denise C. Babineau, Abhik Das, Sara Demauro, Walter K. Kraft, Scott Lorch, Michele C. Walsh, Stephanie Merhar, Lori A. Devlin

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

BACKGROUND: Opioid use and misuse during pregnancy rose from 1.5 to 6.5 per 1000 deliveries between 1999 and 2014 and continues as a significant public health concern. A fivefold increase in neonatal opioid withdrawal syndrome (NOWS) has accompanied the increase in opioid use. The Eating, Sleeping, Consoling care approach (ESC) has been shown to improve outcomes for infants with NOWS and is quickly becoming the standard of care for infants affected by opioid use disorder. Quality improvement initiatives following the implementation of ESC provide some evidence to suggest that symptom-based (i.e., as needed, PRN, just in time) dosing of opioid …

A Protective Role Of Src-1 Against Aging Associated Cognitive Decline, Hesong Liu, Yongjie Yang, Jonathan C Bean, Yang He, Hailan Liu, Rambabu Majji, Chen Liang, Nan Zhang, Meng Yu, Longlong Tu, Qingzhuo Liu, Yue Deng, Kristine M Conde, Na Yin, Mengjie Wang, Yongxiang Li, Junying Han, Sanika Vattakuzhiyil Jossy, Megan Elyse Burt, Hari Krishna Yalamanchili, Chunmei Wang

Duncan NRI Faculty and Staff Publications

Introduction: Research indicates a strong correlation between obesity and the risk of dementia, both are linked to steroid receptor coactivator-1 (SRC-1), a transcriptional coactivator.

Methods: We used RNA sequencing analysis (RNA-Seq) to investigate the transcriptome of SRC-1-KO mice, and identified S100 calcium-binding protein A6 (S100A6), an AD associated gene, as one target of SRC-1. We tested cognitive behaviors in SRC-1-KO mice and mice with a humanized SRC-1 mutation (SRC-1L1376P), and performed promoter luciferase assays on S100A6.

Results: Loss of SRC-1 caused alterations in gene signatures that are commonly associated with neurodegenerative diseases, including AD, and diminished the neural plasticity of …

Computational Fluid Dynamics (Cfd) Modeling For Bio-Inspired Aerodynamic Optimization In Autonomous Drones, Hyginus C.O. Unegbu, Danjuma Saleh Yawas

Makara Journal of Technology

This study explores the aerodynamic benefits of bio-inspired design modifications for autonomous drones using advanced Computational Fluid Dynamics (CFD) simulations. Four bio-inspired configurations—leading-edge serrations, winglets, riblet surfaces, and curved wings—were assessed and compared against a baseline drone model to evaluate their impact on aerodynamic performance. The results indicated that all bio-inspired designs significantly enhanced lift, reduced drag, and improved overall aerodynamic efficiency. The leading-edge serration configuration achieved the highest performance gains, with a 33.6% increase in maximum lift coefficient (CL) and a 29.5% improvement in lift-to-drag ratio (CL/CD), primarily due to delayed flow separation and reduced turbulence. Winglets minimized wingtip …

The 9th Annual Lafora Science Symposium: A Rare Epilepsy Community Makes Progress Towards Clinical Readiness, Meredith I. Williams, Katherine J. Donahue, Pascual Sanz, Souad Messahel, Jose M. Serratosa, Jordi Duran, Roberto Michelucci, Lorenzo Muccioli, Antonio Delgado-Escueta, Viet-Hong Nguyen, Berge A. Minassian, Matthew S. Gentry

Pharmacy Faculty Articles and Research

Lafora disease (LD) is a fatal childhood progressive myoclonus epilepsy and glycogen storage disease that is caused by recessive mutations in either EPM2A or EPM2B. The hallmarks of LD are cytoplasmic, aberrant glycogen-like aggregates, called Lafora bodies (LBs), that drive disease progression. The 9th Annual Lafora Science Symposium was held in San Diego, California and brought together over 70 researchers, clinicians, academic trainees, and friends and family members of patients with LD and 80 attendees joined virtually. This symposium focused primarily on international collaborations for therapeutic development and biomarker identification and strategies for preparing the Lafora community for upcoming …

Adapting To Southwest Idaho's Shifting Wildfire Regime: Sustainable Collaboration As A Means To Socioecological Resilience, Olivia Awbrey

Dissertations and Theses

Community wildfire adaptation is happening at multiple scales across the western United States. A range of collaboratively formed groups have addressed compounding issues related to wildfire risk, forest health and land use. In Southwestern Idaho, place-based collaboratives emerging in the early 2000s have considered trade-offs between localized social and ecological needs as they approach wildfire adaptation from the bottom-up. More recently, regional partnerships have emerged that emphasize cross-boundary wildfire risk reduction to cover larger geographic areas for risk mitigation. In between these micro- and macro-scales of activity exist bridging agencies such as county and state-level programs that account for gaps …