Digital Commons Network^™

Genome-Wide Profiling Of Trna Modifications By Induro-Trnaseq Reveals Coordinated Changes, Yuko Nakano, Howard Gamper, Henri Mcguigan, Sunita Maharjan, Jiatong Li, Zhiyi Sun, Erbay Yigit, Sebastian Grünberg, Keerthana Krishnan, Nan-Sheng Li, Joseph Piccirilli, Ralph Kleiner, Nicole Nichols, Brian Gregory, Ya-Ming Hou

Department of Biochemistry and Molecular Biology Faculty Papers

While all native tRNAs undergo extensive post-transcriptional modifications as a mechanism to regulate gene expression, mapping these modifications remains challenging. The critical barrier is the difficulty of readthrough of modifications by reverse transcriptases (RTs). Here we use Induro-a new group-II intron-encoded RT-to map and quantify genome-wide tRNA modifications in Induro-tRNAseq. We show that Induro progressively increases readthrough over time by selectively overcoming RT stops without altering the misincorporation frequency. In a parallel analysis of Induro vs. a related RT, we provide comparative datasets to facilitate the prediction of each modification. We assess tRNA modifications across five human cell lines and …

Development And Characterization Of Cd44-Targeted X-Aptamers With Enhanced Binding Affinity For Cancer Therapeutics, Hongyu Wang, Weiguo He, Miguel-Angel Elizondo-Riojas, Xiaobo Zhou, Tae Jin Lee, David G Gorenstein

Faculty, Staff and Student Publications

CD44, a pivotal cell surface molecule, plays a crucial role in many cellular functions, including cell-cell interactions, adhesion, and migration. It serves as a receptor for hyaluronic acid and is involved in lymphocyte activation, recirculation, homing, and hematopoiesis. Moreover, CD44 is a commonly used cancer stem cell marker associated with tumor progression and metastasis. The development of CD44 aptamers that specifically target CD44 can be utilized to target CD44-positive cells, including cancer stem cells, and for drug delivery. Building on the primary sequences of our previously selected thioaptamers (TAs) and observed variations, we developed a bead-based X-aptamer (XA) library by …

Minerals And Human Health: From Deficiency To Toxicity, Mohammed S. Razzaque, Sunil J. Wimalawansa

School of Medicine Publications

Minerals are essential nutrients that play critical roles in human health by regulating various physiological functions. Examples include bone development, enzyme function, nerve signaling, and the immune response. Both the deficiencies and toxicities of minerals can have significant health implications. Deficiencies in macrominerals such as calcium, magnesium, and phosphate can lead to osteoporosis (associated with falls and fractures), cardiovascular events, and neuromuscular dysfunction. Trace mineral deficiencies, such as iron and zinc. Selenium deficiency impairs oxygen transport, immune function, and antioxidant defenses, contributing to anemia, delaying wound healing, and increasing susceptibility to infectious diseases. Conversely, excessive intake of minerals can have …

Demetrius Boyd

African American Funeral Programs

Demetrius_Boyd.pdf - Funeral program for Demetrius Boyd

The Evolving Coast By Richard A. Davisjr, C. Nicholas Raphael

The Geographical Bulletin

The most obvious and attractive boundary to people is that which separates the land from the sea. Although shorelines have been examined and classified since the early part of this century (e.g. Gulliver, 1899: Suess, 1909), understanding of their hazards and the consequence of reckless development seems, until quite recently, to have passed us by.

The Right To Receive Information: Conceptual Problems, Shrutanjaya Bhardwaj Mr

Indian Journal of Law and Technology

This article studies the “right to receive information” or the “right to know”, a judicially-recognised right under Article 19(1)(a) of the Constitution. It attempts to show, through an analysis of judgments of the Supreme Court and High Courts, that the right rests on a shaky philosophical foundation and that there are inconsistencies in how the right is judicially treated in terms of its structure and content.

First, the article questions the logic that the “right to know” is implicit in Article 19(1)(a) merely because it makes the exercise of free speech more meaningful. Such a logic was authoritatively rejected by …

Social Jetlag Alters Markers Of Exercise-Induced Mitochondrial Adaptations In The Heart, Michael B. Dial, Elias M. Malek, Austin R. Cooper, Greco A. Neblina, Nikoleta I. Vasileva, Graham Mcginnis

Kinesiology and Nutrition Sciences Faculty Research

Social jetlag (SJL) represents the behavioral misalignment of sleep and wake times on work days and free days, and potently disrupts the circadian rhythm. SJL affects up to 70% of the population worldwide and is associated with increased risk for many cardiometabolic diseases. Animal models of acute SJL have shown disruption in locomotor activity and expression of clock genes in select tissues, its impact on the heart remains unclear. The purpose of this study was to investigate the effects of prolonged SJL (6 weeks), on activity rhythms, and the impact on exercise-induced adaptations in the heart. Male mice (n …

Increasing Atmospheric Evaporative Demand Across The Tibetan Plateau And Implications For Surface Water Resources, Shiqin Xu, Dennis P. Lettenmaier, Tom R. Mcvicar, Pierre Gentine, Hylke E. Beck, Joshua B. Fisher, Zhongbo Yu, Ningpeng Dong, Akash Koppa, Matthew F. Mccabe

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The Tibetan Plateau, known as the “Asian water tower,” is a hotspot for complex hydroclimatic changes. We reveal that the previously decreasing atmospheric evaporative demand (Eo) trend at the end of the 20th century has reversed over the last two decades. Although both wind stilling and solar dimming have persisted, their effects on Eo rates have been overshadowed by increasing air temperatures and decreasing relative humidity, leading to a net rise in Eo for 1980−2015. Using the empirical “top-down” Budyko approach, we estimate that across seven sub-catchments draining the Tibetan Plateau, a 10% increase in annual-averaged …

Contemporary Views Of Spiritual And Theological Reflection (2013-2023) Compared To Forty Years Ago: Analysis Of 32 Texts, Chris Brouillard-Coyle, Des Mcenaney, Joselin Zak, Thomas St. James O’Connor

Consensus

What are contemporary views on spiritual and theological reflection? We answer this question using a hermeneutical research method analyzing 32 texts from the current situation. The data indicate five themes: 1) experiences as sources for spiritual/theological reflection, 2) meaning making as key component for spiritual/theological reflection, 3) growth in spiritual reflection and overlap with theological reflection, 4. some flexible methods; many without explicit method, and 5) spiritual but not religious. Discussion, limitations, and areas for future research are provided.

Correlates Of Inaccuracy In Reporting Of Energy Intake Among Persons With Multiple Sclerosis, Stephanie L Silveira, Brenda Jeng, Barbara A Gower, Gary R Cutter, Robert W Motl

Faculty, Staff and Student Publications

BACKGROUND/OBJECTIVES: Persons with multiple sclerosis (MS) are interested in diet as a second-line approach for disease management. This study examined potential variables that correlate with inaccuracy of self-reported energy intake (EI) in adults with MS.

METHODS: Twenty-eight participants completed two assessment appointments within a 14-day period that included a standard doubly labeled water (DLW) protocol for estimating total energy expenditure (TEE). The participants reported their EI using the Automated Self-Administered 24 h (ASA24) Dietary Assessment Tool. The primary variables of interest for explaining the discrepancy between TEE and ASA24 EI (i.e., inaccuracy) included cognition (processing speed, visuospatial memory, and verbal …

Hubungan Konsentrasi Pm 2,5 Dengan Keluhan Gangguan Pernapasan Pada Pekerja Uji Mekanis Up Pkb Pulo Gadung, Armando Wijaya Tampubolon, Doni Hikmat Hikmat Ramdhan

National Journal of Occupational Health and Safety

Vehicle emissions including traffic and transportation emissions have become the largest source of particulates in many cities in various countries. Health problems due to particulates from motor vehicles can not only occur around the highway, but can also occur in industries that are in contact with motor vehicles. Under these conditions, researchers wanted to conduct a study at UP PKB Pulo Gadung to see the relationship between PM_2.5 concentrations and complaints of respiratory problems. The study sample totaled 38 people, consisting of mechanical testers and FKM UI community members as a comparison sample. The average result of measurements taken …

Efektivitas Full Body Stretching Dan Edukasi Manual Handling Digital Terhadap Keluhan Musculoskeletal Disorders Pekerja Yantek, Nadia Rosalinda, Anita Sulistyorini, Marji Marji, Supriyadi Supriyadi, Tika Dwi Tama

National Journal of Occupational Health and Safety

Occupational Diseases (PAK) in the form of pain complaints in the skeletal system that cause the work process are called Musculoskeletal Disorders (MSDs). PT. PLN Yantek workers are at risk of experiencing MSDs complaints because the work is done manually and the work posture is less ergonomic. This study aimed to analyze the effect of implementing full-body stretch and digital-based manual handling education and to assess its effectiveness on MSDs. The study used a quasi-experimental method with a one-group pretest-posttest design involving 26 Yantek workers. The intervention was given at 10 meetings, MSDs complaints were measured using the Nordic Body …

The Methodological Problems Of Incorporating Indigenous Philosophy In Collaborative Research, Luthonliu Gangmei, P. Milan Khangamcha

Comparative Philosophy

This paper addresses the methodological challenges inherent in collaborative research endeavours focused on the development of Indigenous philosophy. It argues that these challenges persist due to a lack of recognition of the autonomy and intrinsic philosophical value of ethno-philosophy or Indigenous philosophy. Despite the United Nations acknowledging the significance of indigenous worldviews and their philosophical underpinnings, they are still yet to be fully integrated into the global knowledge domain. The paper highlights the tendency to view indigenous philosophy solely as a cultural asset of indigenous peoples rather than recognizing its broader philosophical relevance. It identifies this as a critical interdisciplinary …

Farm Resilience, Management Practices, And Producer Sentiment: Segmenting Us Farms Using Machine Learning Algorithms, Margaret Lippsmeyer, Michael Langemeier, James R. Mintert, Nathan Thompson

Journal of Applied Farm Economics

Farm managers possess a broad spectrum of capabilities, ranging from tech-savvy, strategically focused managers to those grappling with operational challenges. Our study examines survey data from 403 US commercial producers in order to identify subsets of producers who differ in terms of resilience, management practices, producer sentiment, and other farm characteristics. Utilizing various supervised and unsupervised machine learning techniques, we uncover key farm characteristics that capture the most pronounced variations in survey responses. We then cluster the dataset using these key variables, maximizing separation between clusters and minimizing differences within clusters using Ward’s hierarchical clustering. Fisher’s exact tests are implemented …

Children's Rights Debates, Revisited, Martha Minow

Florida Law Review

A Dunwody distinguished lecture in law that reflects on children's rights.

Virginia Academy Of Sleep Medicine Position Statement On School Start Times In Virginia, Sean Hesselbacher, Mariana Szklo-Coxe, Sachin Relia, Jonathan Gellman, Nicole Mcintyre

Eastern Virginia Medical Journal

The VASM endorses the 2017 AASM position statement that middle and high schools should begin no earlier than 8:30 a.m. The existing and updated scientific literature repeatedly identifies the detrimental impact of early high school start times, and the benefits of delaying start times, on the safety and well-being of students in Virginia. The adverse effects of early school start times on Virginia’s students have been demonstrated, with regards to academic performance, mental health, and driving risks. Data published since the AASM position paper highlight these dangers further. Importantly, recent studies also demonstrate some of the benefits that can come …

The Coming Wave: Technology, Power, And The 21st Century’S Greatest Dilemma, Peter Khooshabeh, Robert Underwood

Joint Force Quarterly

This book review assesses Mustafa Suleyman and Michael Bhaskar’s The Coming Wave: Technology, Power, and the 21st Century’s Greatest Dilemma, which surveys the rapid development of artificial intelligence, synthetic biology, and other general-purpose technologies and the challenge of containing their unintended consequences. Suleyman argues that falling costs, accelerating innovation, increasing autonomy, and broad applicability are expanding the power of individuals and groups while making emerging technologies difficult to control. The reviewers highlight the book’s treatment of artificial intelligence, generative AI, synthetic biology, advanced energy, and quantum technologies, as well as its proposed containment mechanisms, including regulation, technical safety, …

China’S Use Of Armed Coercion: To Win Without Fighting, Ian Forsyth

Joint Force Quarterly

This book review assesses China’s Use of Armed Coercion: To Win Without Fighting, edited by James A. Siebens, which analyzes how China employs military and paramilitary forces to signal, deter, and coerce while remaining below the threshold of armed conflict. Drawing particular attention to the book’s analysis of more than 200 Chinese coercive military operations conducted between 2000 and 2021, the reviewer highlights patterns in Beijing’s use of armed coercion, including its tendency to portray its actions as defensive, apply pressure in territorial disputes, and use military forces as instruments of political signaling. Case studies involving the East and …

Is The Pla Overestimating The Potential Of Artificial Intelligence?, Koichiro Takagi

Joint Force Quarterly

This article analyzes how the People’s Liberation Army views the military potential and limitations of artificial intelligence as part of China’s broader drive toward “intelligentization.” Drawing on approximately 370 military theory articles published in PLA Daily in 2023, the author identifies four principal areas in which the PLA expects AI to transform warfare: situational awareness, military decisionmaking, unmanned weapons, and cognitive domain operations. PLA writings also discuss applications in training, logistics, and weapons development. At the same time, the PLA acknowledges significant risks, including unreliable or biased data, system malfunction, loss of human control, unintended escalation, legal and ethical concerns, …

Reassigning Batson: A Modern Approach, Max Angel

Florida Law Review

In Batson v. Kentucky, the Supreme Court of the United States held that using peremptory challenges to strike jurors solely on their race violates the Equal Protection Clause. Following that decision, the Supreme Court extended Batson to gender-based peremptory challenges, holding that state-sponsored group stereotypes rooted in historical prejudice that bars a potential juror from serving on a jury violates that juror’s equal protection right. As it currently stands, there is no federal statute prohibiting peremptory strikes on the basis of sexual orientation or gender identity. And although some courts at the state and federal level have held such …

Breaking Barriers: Investigating Gender Dynamics In Introductory Physics Lab Classes, Bilas Paul, Shantanu Chakraborty, Ganga Sharma

Georgia Journal of Science

The persistent underrepresentation of women and other gender minorities in physical science fields has been an ongoing concern. This study investigates gender dynamics in introductory physics laboratory courses, focusing on whether students of different gender identities exhibit equal inclination and confidence in conducting lab experiments, and whether they face barriers that impact their participation. Conducted across three institutions and involving non-physics STEM students enrolled in algebra-based and calculus-based physics courses, the study found mixed results, with two institutions showing no significant gender-based differences in participation levels during lab activities, while one institution demonstrated significant differences. Chi-square tests revealed no significant …

Centella Asiatica: Recent Cosmeceutical Uses For Treatment Of Skin Diseases, Iman I. Soliman, Nouran Medhat, Huda Saleh, Mai El Halawany

Bulletin of Faculty of Pharmacy Cairo University

Centella asiatica is one of the well-known herbal species used in traditional medicine across Asia such as India, Indonesia, and China. It had been used as a medicinal plant for hundreds of years. Besides its general pharmacological activities such as neuroprotection, anti-cancer and anti-diabetes. It demonstrated effective dermatological actions as being a potent anti-inflammatory, antioxidant, healing and moisturizing properties. The major constituents responsible for these effects were triterpenoids. Triterpenoids included asciaticoside which was reported to induce collagen synthesis. Madecassoside was known for its wound healing properties. It was well known for its efficiency in improving the treatment of hypertrophic wounds. …

Genomic And Proteomic Analyses Of Bacterial Communities Of Ixodes Scapularis Ticks From Broome County, New York, Michel Shamoon-Pour, Emily H. Canessa, John Macher, Amaan Fruitwala, Emma Draper, Benjamin Policriti, Matthew Chin, Matthew Nunez, Paul Puccio, Yuan Fang, Xin-Ru Wang, Yetrib Hathout

Pharmacy Faculty Scholarship

The microbial communities of Ixodes scapularis, the primary vector of Lyme disease in North America, exhibit regional variations that may affect pathogen transmission and vector competence. We analyzed bacterial communities in I. scapularis ticks collected from Broome County, New York, using 16S rRNA gene sequencing (18 ticks) as well as mass spectrometry-based proteomics (36 ticks). According to the 16S rRNA analysis, the endosymbiont Rickettsia buchneri was the most abundant species, with significantly higher (p = 0.0011) abundance in females (54.76%) compared to males (31.15%). We detected Borreliella burgdorferi in 44.44% of ticks and Anaplasma phagocytophilum in two nymphs but in …

The Beacon, January 24, 2025, Beacon Staff

The Beacon, 2024-2025

Unsung Hero: Lori Bonnema; Come enjoy a night of dancing; Zendaya and Holland spark online frenzy; "Wicked" lives up to Broadway original; 2025 fashion throwbacks and throwaways; Heritage Singers present Madrigal Dinners; Comfort to those from far away; Unsung Hero: Lori Bonnema; Diaper drive at local church; Latin dance night; The sad reality of New Year's resolutions; You should try failure; Van Kalsbeek takes down 20-uear-old record; Track and field begins 2025 season; Wrestling charging through 2024-25 season; MLK chapel is moving to many; We all know the BINGO event is not getting old;

The Scarlet - Volume Ciii, No. 7 (January 24, 2025), Scarlet Staff

The Scarlet (Student Newspaper) (2011-present)

The January 24, 2025 edition of The Scarlet (est. 1939), Clark University's student-run newspaper. The Scarlet is intellectually and editorially independent of the University.

The Bison, January, 24, 2025

The Bison Newspapers

No abstract provided.

2025-1-24 Minutes Of The Academic Senate, University Of Dayton. Academic Senate

Academic Senate Minutes

Approved minutes of a meeting of the Academic Senate of the University of Dayton.

Central Line Associated Bloodstream Infection Prevention In Medical Intensive Care Unit, Linet Angir

Walden Dissertations and Doctoral Studies

. The doctoral project was a collaborative endeavor focused on central line dressing sites at a state university hospital in the northeastern United States. The aim was to reduce the current central line-associated infections (CLABSIs) rate. Through audits, it was discovered that most central line dressings needed to be completely sealed, some required insertion site clipping to ensure a complete seal, and some dressings were saturated. To uphold a commitment to quality care, clinical excellence, patient care, and superior outcomes, the Doctor of Nursing Practice (DNP) project recognized the importance of implementing the recommendations to reduce CLABSIs by maintaining central …

Chem 221-004: Analytical Chem Methods, Hao Chen

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Chem 244a-006: Organic Chemistry Lab, Chumeng Lu

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.