Digital Commons Network^™

Chem 244a-102: Organic Chemistry I Lab, Bingyi Liang

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Eps 202-452: Society, Technology And Environment, Micheal Bonchonsky

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Evsc 125-002: Fundamentals Of Environmental Science, Micheal Bonchonsky

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Evsc 340-452: Environmental Health, Micheal Bonchonsky

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Frsc 307-002: Crime Scene Investigation Lab, Kevin Parmelee

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Frsc 307-004: Crime Scene Investigation & Lab, Kevin Parmelee

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Chem 361-002: Environmental Chemistry Of Wter And Soil Pollution, Alexei Khalizov

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Chem 673-104: Biochemistry, Patrick Depaolo

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Chem 244a-004: Organic Chemistry I Lab, Alfredo Castro

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Comprehensive Analysis Of High-Dimensional, Longitudinal Multi-Modal Molecular And Electronic Health Record Data, Jessica Zielinski

MUSC Theses and Dissertations

Healthcare is poised to comprise over a third of the market for big data by 2032, making it the dominant sector in this field (Insights 2024). This growth is driven by the increasing volume and variety of data sources, including electronic health records, payer records, research studies, personal health devices, and smartphones. The integration of such data holds transformative potential, enabling earlier disease diagnosis through biomarker identification, advancing preventive care by pinpointing risk factors, and enhancing hospital quality standards, among other benefits. Despite these promising applications, significant challenges arise in processing and analyzing high-dimensional biomedical data. This dissertation focuses on …

Frsc 479-002: Forensic Biology, Sara Zapico

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Chem 244a-008: Organic Chemistry I Lab, Bingyi Liang

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Chem 475-002: Biochemistry Lab, Edgardo Farinas

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Chem 473-002: Biochemistry, Bhavani Balasubramanian

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Evsc 623-852: Environmental Health, Micheal Bonchonsky

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Chem 244a-104: Organic Chemistry Lab I, Chunmeng Lu

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Review Of New Treatment Options For Toxoplasmosis, Kiley Roman

D.U.Quark

Toxoplasmosis is an infectious disease caused by the parasite, Toxoplasma Gondii. The parasite is often carried in cats and contaminated food and water. Toxoplasmosis is not serious most of the time but can be harmful to immunocompromised people, pregnant women, and their fetuses or babies. Treatments are commonly given to the immunocompromised. However, there are problems with the current treatments, in which they only treat active parasites and cannot remove the cysts created by disease progression. Due to the treatments’ inability to remove cysts, an infected person may not fully recover from the infection. This review evaluated the new …

Using Rna-Sequencing To Explore Mechanistic Markers, New Therapeutics, And Immune Imbalance: A Study Of Cancer And Autoimmunity Through The Lens Of Triple Negative Breast Cancer, Systemic Lupus Erythematosus, And B-Cell Non-Hodgkin's Lymphoma, Naomi Lydia Rapier-Sharman

Theses and Dissertations

Cancer and autoimmune diseases both impose a substantial healthcare burden on the US and world populations. In 2016, there were over 17 million cases of cancer, leading to nearly nine million deaths. Additionally, autoimmune diseases cause substantial mortality and morbidity and are present in 3-5% of the general population. Despite the increased attention scientists now give diseases that are impacted by immune imbalance, we have yet to find regimens to treat the core cause(s) of tissue dysfunction without drastically decreasing the quality of life for many patients with either cancer or autoimmune disease. For instance, anti-CD19 Chimeric Antigen Receptor (CAR) …

Developing A Citizen Science Approach To Monitor Stranded Marine Plastics On A Remote Small Island In Indonesia, Radisti A. Praptiwi, Carya Maharja, Fauzan Cholifatullah, Dwi Cj Subroto, Sainal Sainal, Peter I. Miller, Vikki Cheung, Tatang Mitra Setia, Nasruddin, Datu, Jito Sugardjito, Melanie Austen

School of Psychology

Marine plastics stranded on the coastlines of remote small islands threaten both the ecological integrity of local ecosystems and communities’ well-being. However, despite the growing quantities of stranded plastics in these locations, the remote nature of these sites renders monitoring and intervention efforts difficult to undertake. Within this context, we developed a citizen science approach to monitor stranded marine plastics in collaboration with villagers living on a remote small island in Indonesia. This study reports the co-development and application of an approach that can be used and maintained independently by remote coastal communities. In the monitoring stage, the participants quantified …

Social, Racial, And Economic Disparities Affecting Outcomes Of Hypertensive Adolescents, Kanya Singhapakdi, Amelia Haydel, Marla Johnston, Shengping Yang, Tamara Bradford, Dedrick Moulton, Thomas R. Kimball

School of Medicine Faculty Publications

Essential hypertension is one of the most common conditions managed in pediatric cardiology and can result in lasting deleterious effects on the cardiovascular system. Pediatric hypertension is so prevalent in the United States that it is often referred to as a public health challenge. Social determinants of health (SDH) are the cultural, economic, educational, healthcare accessibility, and political influences in the environment in which an individual is born or lives, all of which can affect that individual's overall health. This study investigated the impact of social determinants such as rurality, food insecurity, transportation challenges, minority status, income, and race on …

Prevalence Of Autoimmune Diseases In Patients Treated With Immune Checkpoint Inhibitors: An Epidemiological Study Using A Global Network Of Health Care Organizations, Pushti Khandwala, Devashish Desai, Arthur Lau

Einstein Health Papers

OBJECTIVE: Evaluate prevalence of new onset autoimmune conditions (ACs) after commencement of immune checkpoint inhibitors (ICIs).

METHODS: This retrospective observational study was done using TriNetX. Patients with neoplasm for which ICIs were approved were stratified into two groups based on ICI use. Multivariate Cox proportional hazard models and Kaplan Meier method were used to assess risk of developing ACs among the groups. Subgroup analysis was done to evaluate risk of ACs in patients receiving cytotoxic T-lymphocyte-associated protein 4 inhibitor (CTLA4i) versus program cell death protein 1 inhibitor (PD1i) and program death ligand 1 inhibitor (PDL1i) inhibitors and combination treatment (CT) …

Central Line Associated Bloodstream Infection Prevention In Medical Intensive Care Unit, Linet Angir

Walden Dissertations and Doctoral Studies

. The doctoral project was a collaborative endeavor focused on central line dressing sites at a state university hospital in the northeastern United States. The aim was to reduce the current central line-associated infections (CLABSIs) rate. Through audits, it was discovered that most central line dressings needed to be completely sealed, some required insertion site clipping to ensure a complete seal, and some dressings were saturated. To uphold a commitment to quality care, clinical excellence, patient care, and superior outcomes, the Doctor of Nursing Practice (DNP) project recognized the importance of implementing the recommendations to reduce CLABSIs by maintaining central …

As-988-25 Resolution In Support Of Cal Poly's Transgender And Gender Non-Conforming Community, Academic Senate

Academic Senate Resolutions

Resolves that the Cal Poly Academic Senate unequivocally affirms its support for the rights, safety, and well-being of members of the Cal Poly community who identify as transgender, gender non-conforming, or any other identity encompassed within the LGBTQIA+ community; and it further resolves that the Academic Senate supports members of the Cal Poly community who identify as transgender, gender non-conforming, or any other identity encompassed within the LGBTQIA+ community and encourages the administration to continue implementing and expanding initiatives that provide education and training on gender inclusivity for all students, faculty, and staff; ensure access to gender-inclusive facilities, including restrooms …

The Quic-Sp: A Spanish Language Tool Assessing Unpredictability In Early Life Is Linked To Physical And Mental Health, Sabrina R. Liu, Natasha A. Bailey, Sara Romero-González, Amy Moors, Belinda Campos, Elysia P. Davis, Laura M. Glynn

Psychology Faculty Articles and Research

Accumulating evidence indicates that unpredictable signals in early life represent a unique form of adverse childhood experiences (ACEs) associated with disrupted neurodevelopmental trajectories in children and adolescents. The Questionnaire of Unpredictability in Childhood (QUIC) was developed to assess early life unpredictability, encompassing social, emotional, and physical unpredictability in a child’s environment, and has been validated in three independent cohorts. However, the importance of identifying ACEs in diverse populations, including non-English speaking groups, necessitates translation of the QUIC. The current study aims to translate and validate a Spanish language version of the QUIC (QUIC-SP) and assess its associations with mental and …

Ethnic Disparities In Hba1c And Hypoglycemia Among Youth With Type 1 Diabetes: Beyond Access To Technology, Social Deprivation And Mean Blood Glucose, J. Pemberton, Zhide Fang, Stuart Chalew, S. Uday

School of Public Health Faculty Publications

Introduction The UK national pediatric diabetes audit reports higher HbA1c for children and young people (CYP) with type 1 diabetes (T1D) of Black ethnicity compared with White counterparts. This is presumably related to higher mean blood glucose (MBG) due to lower socioeconomic status (SES) and less access to technology. We aimed to determine if HbA1c ethnic disparity persists after accounting for the above variables. Research design and methods A retrospective analysis of participants who received structured education in continuous glucose monitoring (CGM) use was conducted at a tertiary center. HbA1c was paired with glucose metrics from 90-day CGM data. The …

Spatial Transcriptome Reveals Histology-Correlated Immune Signature Learnt By Deep Learning Attention Mechanism On H&E-Stained Images For Ovarian Cancer Prognosis, Chun Wai Ng, Kwong-Kwok Wong, Barrett C Lawson, Sammy Ferri-Borgogno, Samuel C Mok

Faculty, Staff and Student Publications

Background: The ability to predict the prognosis of patients with ovarian cancer can greatly improve disease management. However, the knowledge on the mechanism of the prediction is limited. We sought to deconvolute the attention feature learnt by a deep learning convolutional neural networks trained with whole-slide images (WSIs) of hematoxylin-and-eosin (H&E)-stained tumor samples using spatial transcriptomic data.

Methods: In this study, 773 WSIs of H&E-stained tumor sections from 335 patients with treatment naïve high-grade serous ovarian cancer who were included in The Cancer Genome Atlas (TCGA) Pan-Cancer study were used to train, and validate, and to test a ResNet101 CNN …

Adverse Side Effects Of Hemodialysis In Patients With End-Stage Chronic Renal Disease At Kassala Dialysis Center, Sudan, Muzamil Ahmed, Mustafa Khairelseed, Muzdlefa Ahmed, Mutaz Mohammed, Mutaz Omara

Iraqi National Journal of Medicine

Background: Hemodialysis is a treatment for advanced renal failure; however, various complications can arise following the procedure. Aim: This study aimed to investigate the incidence of adverse side effects during hemodialysis in patients with chronic renal failure. Methods: This descriptive hospital-based study was conducted on 105 patients treated with hemodialysis between November 2020 and January 2021 at the Kassala Dialysis Center in Kassala City, Kassala State, Sudan. Data were collected through interviews using a questionnaire designed to address the research questions. The data were analyzed using the software Statistical Package for the Social Sciences version 16. Results: The findings indicated …

Case Report: A Durable Response To Anastrozole Re-Challenge With Everolimus In A Patient With Advanced-Stage Estrogen Receptor-Positive Breast Cancer, Vincent Emma P Weiss

Iraqi National Journal of Medicine

Estrogen receptor-positive breast cancer is a heterogeneous disease characterized by its dependence on estrogen for growth and progression. Although hormonal therapy remains the cornerstone of treatment, many patients eventually develop resistance, leading to recurrence and disease progression. This case report describes a durable response to a rechallenge with Anastrozole (Arimidex) in combination with Everolimus (Afinitor), an mTOR inhibitor, in a patient with advanced (stage IV) ER+ metastatic breast cancer.

Single-Molecule Dna-Flow Stretching Assay As A Versatile Hybrid Tool For Investigating Dna-Protein Interactions, Sadaf Shehzad, Hyeongjun Kim

Physics & Astronomy Faculty Publications

Single-molecule techniques allow researchers to investigate individual molecules and obtain unprecedented details of the heterogeneous nature of biological entities. They play instrumental roles in studying DNA-protein interactions due to the ability to visualize DNA or proteins and to manipulate individual DNA molecules by applying force or torque. Here, we describe single-molecule DNA-flow stretching assays as hybrid tools that combine forces with fluorescence. We also review how widely these assays are utilized in elucidating working mechanisms of DNA-binding proteins. Additionally, we provide a brief explanation of various efforts to prepare DNA substrates with desired internal protein-binding sequences. More complicated needs for …

Atm Expression And Activation In Ataxia Telangiectasia Patients With And Without Class Switch Recombination Defects, Fereshte Salami, Tannaz Moeini Shad, Nazanin Fathi, Hanieh Mojtahedi, Marzie Esmaeili, Sepideh Shahkarami, Ladan Gol Mohammad Pour Afrakoti, Parisa Amirifar, Samaneh Delavari, Hassan Nosrati, Azadehsadat Razavi, Mohammad Reza Ranjouri, Mahsa Yousefpour, Zahra Hamidi Esfahani, Gholamreza Azizi, Mahmoudreza Ashrafi, Nima Rezaei, Reza Yazdani, Hassan Abolhassani

Department of Neurology Faculty Papers

BACKGROUND: Ataxia telangiectasia mutated (ATM) kinase plays a critical role in DNA double-strand break (DSB) repair. Ataxia telangiectasia (A-T) patients exhibit abnormalities in immunoglobulin isotype expression and class switch recombination (CSR). This study investigates the role of residual ATM kinase expression and activity in the severity of A-T disease.

METHODS: A-T patients with defined genetic diagnoses were classified based on CSR and based on the severity of their medical complications. Isolated peripheral blood mononuclear cells from any patient were evaluated before and after exposure to 0.5 Gy ionizing radiation for one minute. Western blotting was performed to identify the expression …