Digital Commons Network^™

Investigating The Impact Of Sorghum On Tau Protein Phosphorylation And Mitochondrial Dysfunction Modulation In Alzheimer’S Disease: An In Vitro Study, Nasim Rezaee, Eugene Hone, Hamid Sohrabi, Rasheed Abdulraheem, Stuart K. Johnson, Stuart Gunzburg, Ralph N. Martins, W. M.A.D.Binosha Fernando

Research outputs 2022 to 2026

Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with poorly understood pathology. Elevated tau, phospho-tau and mitochondrial dysfunction are significantly correlated with an increased risk of AD and are therefore targets for disease-modifying therapy. In this study, we examined the effects of polyphenolic extracts from six different varieties of sorghum: Shawaya short black-1 (Black), IS1311C (Brown), QL33/QL36 (Red), B923296 (Red), QL12 (White), and QL33 (Red) on the attenuation of beta amyloid-induced phospho-tau levels, total tau levels, and mitochondrial dysfunction in neuronal cells. Method: Tau proteins (231 (pT231), Serine- 199 (pS199), and total tau proteins (T-tau)) were detected and quantified …

Sparse Seagrass Meadows Are Critical Dugong Habitat: A Novel Rapid Assessment Of Habitat-Wildlife Associations Using Paired Drone And In-Water Surveys, Nicole E. Said, Christophe Cleguer, Paul Lavery, Amanda J. Hodgson, Connor Gorham, Julian A. Tyne, Ankje Frouws, Simone Strydom, Johnny Lo, Holly C. Raudino, Kelly Waples, Kathryn Mcmahon

Research outputs 2022 to 2026

Understanding the fine-scale behavioural and feeding ecology of marine megafauna is imperative for effective management of their habitat areas; however, obtaining the relevant data can be both costly and challenging. Here we integrate the use of small drones for dugong surveys with underwater benthic habitat assessment techniques at the local spatial scale (∼30 km2), to determine the drivers of dugong (Dugong dugon) distribution across three locations in the Pilbara, Western Australia. Paired assessment data was collected three times over two years. Benthic habitat (percent cover), seagrass nutritional quality and environmental parameters (temperature, water clarity, water current, water depth) were tested …

A Living Feminist Postdevelopmental Lexicon For Early Education, Mindy Blaise, Veronica Pacini-Ketchabaw

Research outputs 2022 to 2026

Expanding the important body of work that addresses child development’s limitations and responding to the ecological crisis that threatens the future of life on Earth, this article proposes a living feminist postdevelopmental lexicon. The lexicon introduces 26 concepts that together challenge the theory/practice divide, disrupt Cartesian modes of subjectivity, reorient taken-for-granted ideas as problematic in early education, open up early education to inquiries that respond to the political and ethical questions of our milieu, and generate conditions for creative, inventive, thoughtful, and ethical projects. The paper invites readers to engage with and creatively add to the lexicon, making it an …

The Influence Of Climate On The Invasion Of The Asian Hornet (Vespa Velutina) To Guernsey, Channel Islands: Citizen Science And Misidentified Aliens, Laura C. Wade, Francis J. Russell, Ashwitha L. Aranha, Mairi E. Knight, Jonathan S. Ellis

School of Biological and Marine Sciences

Vespa velutina is an Asian bee-hawking hornet that has rapidly colonised continental Europe since its accidental introduction in 2004. Its range continues to expand with the first confirmed sightings in Guernsey in 2017. This study aimed to analyse local weather variables over three years to assess their importance for predicting Asian hornet occurrences. We also investigated citizen science reporting to ascertain which species the public most commonly misidentify as Asian hornets. Weather analysis using zero-inflated negative binomial regression showed that Asian hornet observations are more likely in warmer weather (air temperature > 12 °C). The year 2019 significantly affected the likelihood …

Looking Out For Danger: Theoretical And Empirical Issues In Translating Human Attention Bias Tasks To Assess Animal Affective States, Sarah Kappel, Sarah Collins, Michael Mendl, Carole Fureix

School of Biological and Marine Sciences

Understanding animal emotional (affective) state is highly relevant to various disciplines (e.g., animal welfare, neuroscience, comparative psychology), and has been significantly advanced by translating affect-induced cognitive bias paradigms rooted in human psychology to non-human animal studies. Attention bias (i.e., preferential attention allocation, AB) tests are increasingly used as more practical substitutes to commonly used judgement bias tests. Yet, evidence that AB reflects affective valence in animals is still limited. We review in-depth the concept of attention and AB described in humans and discuss utilising human-derived AB paradigms for measuring animal affective states. We describe key concepts and functions of attention …

Voices From The Field: Mental Health Therapists' Perceptions Of Collaboration With Child Protective Services Workers, Tamara P. Fields

Electronic Theses and Dissertations

The child welfare system in the United States requires collaboration across various agencies in the provision of services. Although collaboration between mental health therapists and state agencies is fundamental when the goal is to provide quality care and achieve positive outcomes for families involved with Child Protective Services (CPS), the system is characterized as complicated and fragmented. Using Bronstein’s 2003 model of interprofessional collaboration to understand the dynamics of collaboration between mental health therapists and CPS workers in Texas, this qualitative descriptive research study described mental health therapists’ perceptions of collaborating with CPS workers in delivering therapy services to CPS-involved …

Neural Processes Of Emotional Conflict Detection And Prediction Of Posttraumatic Stress Disorder Symptom Clusters In Traumatic Injury Survivors, Kaley E. Davis, Carissa W. Tomas, Kate E. Webb, Ashley A. Huggins, Terri A. Deroon-Cassini, Christine L. Larson, Jacklynn M. Fitzgerald

Psychology Faculty Research and Publications

Objective: Given the prevalence and significant burden of posttraumatic stress disorder (PTSD), identifying early predictors of symptom development following trauma is critical. PTSD is a heterogeneous disorder comprised of distinct symptom clusters-reexperiencing, avoidance, negative mood, and hyperarousal-that contribute to the broad range of possible symptom profiles. Affective and attentional regulation processes, such as emotional conflict detection, are impaired in individuals with PTSD; however, the neural mechanisms underlying these alterations and their predictive utility for the development of PTSD symptoms remain unclear.

Method: Traumatic injury survivors (N = 49) without traumatic brain injury were recruited from the emergency department of …

Covid-19-Related Risk, Resilience, And Mental Health Among Mexican American Mothers Across The First Year Of The Pandemic, Amy L. Non, Elizabeth S. Clausing, Sandraluz Lara-Cinisomo, Kimberly D'Anna-Hernandez

Psychology Faculty Research and Publications

Background

Latina mothers have been especially affected by the pandemic and historically exhibit high rates of depression and anxiety. However, few longitudinal studies have assessed the effect of the pandemic on this vulnerable population. We hypothesized that COVID-19-related stressors would associate with psychological distress among Latina mothers across the first year of the pandemic.

Methods

We investigated COVID-19-related impact, stigma, and fears across two critical time points and changes in these measures in relation to changes in maternal anxiety and depression among mothers of Mexican descent living in Southern California (n=152). Surveys were administered within 5–16 weeks of …

Comparison Between The Partial Least Squares Method And Principal Components Using Genetic Algorithm With An Application, Hayder Osman Hussein, Rabab Abdul Rida Al-Bakri

Journal of Economics and Administrative Sciences

The problem of multicollinearity among independent variables in a regression model was addressed in this study using Partial Least Squares (PLS) and Principal Component Analysis (PCA). The influence exerted by multicollinearity can deteriorate the results of regression modeling; that is, it makes the traditional technique OLS less reliable. The research is centered on applying advanced algorithms for Partial Least Squares (SIMPL and O-PLS) as well as for PCA (NIPALS and SVD) on real-life data scenarios, as well as integrating genetic algorithm (GAs) with these algorithms to optimize predictive performance. The relative efficiency of these methods is evaluated primarily through the …

Ags3-Based Optogenetic Gdi Induces Gpcr-Independent Gβγ Signalling And Macrophage Migration, Waruna Thotamune, Sithurandi Ubeysinghe, Chathuri Rajarathna, Dinesh Kankanamge, Koshala Olupothage, Aditya Chandu, Bryan A Copits, Ajith Karunarathne

2020-Current year OA Pubs

G-protein-coupled receptors (GPCRs) are efficient guanine nucleotide exchange factors (GEFs) and exchange GDP to GTP on the Gα subunit of G-protein heterotrimers in response to various extracellular stimuli, including neurotransmitters and light. GPCRs primarily broadcast signals through activated G proteins, GαGTP and free Gβγ and are major disease drivers. Evidence shows that the ambient low threshold signalling required for cells is likely supplemented by signalling regulators such as non-GPCR GEFs and guanine nucleotide dissociation inhibitors (GDIs). Activators of G-protein signalling 3 (AGS3) are recognized as a GDI involved in multiple health and disease-related processes. Nevertheless, understanding of AGS3 is limited, …

On The Acceptance, Commissioning, And Quality Assurance Of Electron Flash Units, Allison Palmiero, Kevin Liu, Julie Colnot, Nitish Chopra, Denae Neill, Luke Connell, Brett Velasquez, Albert C Koong, Steven H Lin, Peter Balter, Ramesh Tailor, Charlotte Robert, Jean-François Germond, Patrik Gonçalves Jorge, Reiner Geyer, Sam Beddar, Raphael Moeckli, Emil Schüler

Faculty, Staff and Student Publications

Background and purpose: FLASH or ultra-high dose rate (UHDR) radiation therapy (RT) has gained attention in recent years for its ability to spare normal tissues relative to conventional dose rate (CDR) RT in various preclinical trials. However, clinical implementation of this promising treatment option has been limited because of the lack of availability of accelerators capable of delivering UHDR RT. Commercial options are finally reaching the market that produce electron beams with average dose rates of up to 1000 Gy/s. We established a framework for the acceptance, commissioning, and periodic quality assurance (QA) of electron FLASH units and present an …

Frailty And Sleep In Adult Survivors Of Childhood Cancer: A Childhood Cancer Survivor Study Report, Lauren C Daniel, Margaret M Lubas, Huiqi Wang, Mariana Szklo-Coxe, Kirsten K Ness, Annalynn M Williams, Daniel A Mulrooney, Rebecca Howell, Wendy Leisenring, Yutaka Yasui, Leslie L Robison, Gregory T Armstrong, Eric J Chow, Kevin R Krull, Tara M Brinkman

Faculty, Staff and Student Publications

Background: Young adult survivors of childhood cancer exhibit rates of frailty similar to adults several decades older without a cancer history. Frailty has been associated with sleep disturbances in non-cancer populations, but the relationship has not been examined in childhood cancer survivors who are known to exhibit elevated rates of sleep problems.

Aims: Examine associations between frailty and poor sleep quality in long-term survivors of childhood cancer.

Methods: This study utilized data from 9044 participants (> 5 years from diagnosis, Mage = 40.8 years [SD = 9.5]) in the Childhood Cancer Survivor Study. Survivors' frailty status, chronic health conditions (CHC), …

Toward A Biological Definition Of Neuronal And Glial Synucleinopathies, Claudio Soto, Brit Mollenhauer, Oskar Hansson, Un Jung Kang, Roy N Alcalay, David Standaert, Claudia Trenkwalder, Kenneth Marek, Douglas Galasko, Kathleen Poston

Faculty, Staff and Student Publications

Cerebral accumulation of alpha-synuclein (αSyn) aggregates is the hallmark event in a group of neurodegenerative diseases-collectively called synucleinopathies-which include Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. Currently, these are diagnosed by their clinical symptoms and definitively confirmed postmortem by the presence of αSyn deposits in the brain. Here, we summarize the drawbacks of the current clinical definition of synucleinopathies and outline the rationale for moving toward an earlier, biology-anchored definition of these disorders, with or without the presence of clinical symptoms. We underscore the utility of the αSyn seed amplification assay to detect aggregated αSyn in living …

Mutational And Co-Mutational Landscape Of Early Onset Colorectal Cancer, Jumanah Yousef Alshenaifi, Guglielmo Vetere, Giulia Maddalena, Mahmoud Yousef, Michael G White, John Paul Shen, Eduardo Vilar, Christine Parseghian, Arvind Dasari, Van Karlyle Morris, Ryan Huey, Michael J Overman, Robert Wolff, Kanwal P Raghav, Jason Willis, Kristin Alfaro, Andy Futreal, Y Nancy You, Scott Kopetz

Faculty, Staff and Student Publications

Introduction: Colorectal cancer (CRC) incidence and mortality before 50 have been rising alarmingly in the recent decades.

Methods: Using a cohort of 10,000 patients, this study investigates the clinical, mutational, and co-mutational features of CRC in early-onset (EOCRC, < 50 years) compared to late-onset (LOCRC, ≥ 50 years).

Results: EOCRC was associated with a higher prevalence of Asian and Hispanic patients, rectal or left-sided tumors (72% vs. 59%), and advanced-stage disease. Molecular analyses revealed differences in mutation patterns, with EOCRC having higher frequencies of TP53 (74% vs. 68%, p < 0.01) and SMAD4 (17% vs. 14%, p = 0.015), while BRAF (5% vs. 11%, p < 0.001) and NOTCH1 (2.7% vs. 4.1%, p = 0.01) mutations …

Refining Diagnostic Subtypes Of Peripheral T-Cell Lymphoma Using A Multiparameter Approach, Catalina Amador, Dennis D Weisenburger, Ana Gomez, Alyssa Bouska, Ahmad Alshomrani, Sunandini Sharma, Ab Rauf Shah, Timothy C Greiner, Francisco Vega, Andreas Rosenwald, German Ott, Andrew L Feldman, Elaine S Jaffe, Neval Ozkaya, Sarah L Ondrejka, James R Cook, Philipp W Raess, Kerry J Savage, Graham W Slack, Joo Y Song, David W Scott, Elias Campo, Lisa M Rimsza, Joseph D Khoury, Louis M Staudt, Wing C Chan, Javeed Iqbal

Faculty, Staff and Student Publications

Peripheral T-cell lymphoma (PTCL) is a heterogeneous category, and many cases are unclassifiable and designated as PTCL-not otherwise specified (PTCL-NOS). Gene expression profiling (GEP) has delineated two prognostic subtypes within PTCL-NOS, PTCL-TBX21, and PTCL-GATA3, characterized by distinctive transcriptomes and a different prognosis. To further evaluate the pathologic features of these subgroups, 101 PTCL cases that did not meet specific criteria for well-defined T-cell lymphoma entities underwent detailed pathologic, immunophenotypic (including TFH biomarkers) and GEP analyses, separating them into PTCL-NOS (n=63) and PTCL-TFH (a.k.a. nodal PTCL-TFH, NOS, and TFH lymphoma, NOS) (n=38). PTCL-NOS cases were further categorized into PTCL-GATA3 (n=22; 34%) …

Preclinical And Clinical-Scale Magnetic Particle Imaging Of Natural Killer Cells: In Vitro And Ex Vivo Demonstration Of Cellular Sensitivity, Resolution, And Quantification, Olivia C Sehl, Yanwen Yang, Ariana R Anjier, Dmitry Nevozhay, Donghang Cheng, Kelvin Guo, Benjamin Fellows, Abdul Rahman Mohtasebzadeh, Erica E Mason, Toby Sanders, Petrina Kim, David Trease, Dimpy Koul, Patrick W Goodwill, Konstantin Sokolov, Max Wintermark, Nancy Gordon, Joan M Greve, Vidya Gopalakrishnan

Faculty, Staff and Student Publications

Purpose: Clinical adoption of NK cell immunotherapy is underway for medulloblastoma and osteosarcoma, however there is currently little feedback on cell fate after administration. We propose magnetic particle imaging (MPI) may have applications for the quantitative detection of NK cells.

Procedures: Human-derived NK-92 cells were labeled by co-incubation with iron oxide nanoparticles (VivoTrax™) for 24 h then excess nanoparticles were washed with centrifugation. Cytolytic activity of labeled versus unlabeled NK-92 cells was assessed after 4 h of co-incubation with medulloblastoma cells (DAOY) or osteosarcoma cells (LM7 or OS17). Labeled NK-92 cells at two different doses (0.5 or 1 × 106) …

Outcomes Of Patients With Treated Secondary Acute Myeloid Leukemia: A High-Risk Subtype That Warrants An Independent Prognostic Designation, Jayastu Senapati, Hagop M Kantarjian, Fadi G Haddad, Nicholas J Short, Gautam Borthakur, Rashmi Kanagal-Shamanna, Guilin Tang, Elias Jabbour, Courtney D Dinardo, Naval Daver, Guillermo Montalban-Bravo, Vishrut Shah, Amin Alousi, Elizabeth Shpall, Uday Popat, Guillermo Garcia-Manero, Farhad Ravandi, Tapan M Kadia

Faculty, Staff and Student Publications

Patients who develop acute myeloid leukemia (AML) after having received treatment for myelodysplastic syndrome (MDS) or related conditions have particularly poor outcomes. This study analyzed adult patients with newly diagnosed AML who previously had MDS, chronic myelomonocytic leukemia (CMML), or MDS/myeloproliferative neoplasm (MPN) overlap syndrome, and who had received hypomethylating agents, chemotherapy, and/or allogeneic stem cell transplantation (HSCT) for these antecedent disorders. From January 2012 to August 2023, we included 673 patients with a median age of 70 years (range, 19-94); 536 (80%) had transformed from MDS, and the remainder from CMML or MDS-MPN. Additionally, 149 patients (22%) had prior …

Using Integrin Αvβ6-Targeted Positron Emission Tomography Imaging To Longitudinally Monitor Radiation-Induced Pulmonary Fibrosis In Vivo, William C Y Lo, Cristian W Villas Boas, Truc T Huynh, Amanda Klaas, Felicia Grogan, Lori Strong, Pamela Samson, Clifford G Robinson, Buck E Rogers, Carmen Bergom

2020-Current year OA Pubs

PURPOSE: Radiation-induced pulmonary fibrosis (RIPF) is a potentially serious and disabling late complication of radiation therapy. Monitoring RIPF progression is challenging due to the absence of early detection tools and the difficulty in distinguishing RIPF from other lung diseases using standard imaging methods. In the lungs, integrin αvβ6 is crucial in the development of RIPF, acting as a significant activator of transforming growth factor β after radiation injury. This study aimed to investigate integrin α

METHODS AND MATERIALS: We used a focal RIPF model (70 Gy delivered focally to a 3 mm spot in the lung) and a whole lung …

Buyer, Beware Of Addiction, Erin E. Meyers, Clayton J. Masterman

Cardozo Law Review

Addictive products kill more than 700,000 people in the United States every year. Despite the large-scale risks that addiction poses, the law requires manufacturers of addictive products to disclose little-to-no information about the risk of addiction—the single most consequential characteristic of a class of products contributing to mass death every year.

While consumers understand that addictive products are, in fact, addictive, they generally do not understand the magnitude of the addiction risks that they face. Metaphorically, consumers understand that they are playing a game of “Russian roulette” when they consume an addictive product—but they play without knowing how many bullets …

Radical Restorative Justice: Reflections On Conflict, Trauma, And Hope In Chicagoland Schools, Amy J. Cohen, Uma Blanchard

Cardozo Law Review

This Article tracks how abolitionist and reformist debates are unfolding within urban schools’ attempts to smash the school-to-prison pipeline. We document how Chicago-area public school teachers are grappling with new restorative justice programs and their complex and divergent sociopolitical and institutional meanings. Drawing on over forty qualitative interviews with teachers, we illustrate how difficult widespread implementation of new conflict resolution mechanisms, in the name of restorative justice, are turning out to be. We analyze how teachers are interpreting restorative justice practices and the challenges they involve for students, educators, and school administrators who learn and teach and work in hierarchical …

The Role Of Adjunctive Medial Plating In Distal Femur Fractures And Distal Femur Fractures Nonunions., Jerrod Steimle, Jaron L Lohmeyer, Benjamin Taylor, Daniel T Degenova

Trauma and Acute Care Articles

PURPOSE: There exists controversy in the treatment of acute distal femur fractures as well as distal femur fracture nonunions. The objective of this study is to determine the clinical benefit of adjunctive medial plate application in the setting of acute distal femur fractures and distal femur fracture nonunions.

METHODS: This is a retrospective comparative study at a Level 1 academic trauma center, including 104 patients treated for acute distal femur fractures and 23 patients treated for distal femur nonunions between 2015 and 2019. The study compared dual plate fixation to other methods of fixation.

RESULTS: In the acute fracture setting, …

High Shear Stress Reduces Erg Causing Endothelial-Mesenchymal Transition And Pulmonary Arterial Hypertension, Tsutomu Shinohara, Jan-Renier Moonen, Yoon Hong Chun, Yannick C. Lee-Yow, Kenichi Okamura, Jason M. Szafron, Jordan Kaplan, Aiqin Cao, Lingli Wang, Weiguang Yang

Mechanical Engineering Faculty Publications

Background: Computational modeling indicated that pathological high shear stress (HSS; 100 dyn/cm2) is generated in pulmonary arteries (PAs; 100-500 µm) in congenital heart defects causing PA hypertension (PAH) and in idiopathic PAH with occlusive vascular remodeling. Endothelial-to-mesenchymal transition (EndMT) is a feature of PAH. We hypothesize that HSS induces EndMT, contributing to the initiation and progression of PAH.

Methods: We used the Ibidi perfusion system to determine whether HSS applied to human PA endothelial cells (ECs) induces EndMT when compared with physiological laminar shear stress (15 dyn/cm2). The mechanism was investigated and targeted to prevent PAH in a mouse with …

The Role Of Childhood Stress In Inflammatory Skin Conditions: A Neuroimmune Investigation, Marissa Ruppe, Colin Burnette, Emily Deehan, Emily Woolhiser, Haily A. Fritts, Kelly Frasier, Aspynn Owsley, Savannah K. Fakhouri, Veronica Rodriguez

Student Publications

Emerging evidence indicates that childhood stressors, such as familial conflict, bullying, academic pressure, and traumatic events, can significantly worsen inflammatory skin conditions like atopic dermatitis (AD) and psoriasis. This review explores the underlying neuroimmune pathways that link stress to skin inflammation in children, focusing on the role of the hypothalamic-pituitary-adrenal (HPA) axis and stress-induced cytokine production. Studies have shown that chronic psychological stress leads to dysregulation of the HPA axis, resulting in elevated cortisol levels, which paradoxically impair skin barrier function and upregulate pro-inflammatory cytokines such as IL-6, TNF-α, and IL-1β. Specific stressors, such as bullying, have been associated with …

Covid-19- In Children Evidence For Treatment With Remdesivir, Children's Mercy Kansas City

Clinical Critically Appraised Topics

No abstract provided.

Predictors Of Bi-Directional Transitions From Mild Cognitive Impairment In A Diverse Cohort, Mitzi M. Gonzales, Roman Fernandez, Sarah Kremen, Zaldy S. Tan, Amy E. Werry, Xueqiu Jian, John Hart, Donald Royall, Gladys Maestre, Sara Espinoza

School of Medicine Publications

Trajectories following a diagnosis of mild cognitive impairment (MCI) are varied and may fluctuate over time. Among diverse ethnic and racial groups, social factors, medical comorbidities, and biases in assessment procedures may contribute to greater heterogeneity in the MCI diagnostic category and affect its prognostic significance for dementia. The study goal was to evaluate the frequency and variables associated with MCI transitions among non-Hispanic White (NHW) and Latinx older adults. Multistate Markov models characterized transitions across diagnostic states (cognitively unimpaired (CU), MCI, dementia) over ten years. Variables associated with transitions were assessed using hazard ratios (HR) and 95% confidence intervals …

Osteoporosis In Relation To A Bone-Related Aging Biomarker Derived From The Urinary Proteomic Profile: A Population Study, Yu-Ling Yu, Dries S. Martens, De-Wei An, Babangida Chori, Agnieszka Latosinska, Justyna Siwy, Augustine N. Odili, Katarzyna Stolarz-Skrzypek, Gladys E. Maestre, Kei Asayama

School of Medicine Publications

Screening for and prevention of osteoporosis and osteoporotic fractures is imperative, given the high burden on individuals and society. This study constructed and validated an aging-related biomarker derived from the urinary proteomic profile (UPP) indicative of osteoporosis (UPPost-age). In a prospective population study done in northern Belgium (1985-2019), participants were invited for a follow-up examination in 2005-2010 and participants in the 2005-2010 examination again invited in 2009-2013. Participants in both the 2005-2010 and 2009-2013 examinations (n = 519) constituted the derivation (2005-2016 data) and time-shifted validation (2009-2013 data) datasets; 187 participants with only 2005-2010 data formed the synchronous validation dataset. …

Development Of 24-Hour Rhythms In Cortisol Secretion Across Infancy: A Systematic Review And Meta-Analysis Of Individual Participant Data, Laura Kervezee, Michelle Romijn, Kirsten N.G. Van De Weijer, Britney S.J. Chen, George L. Burchell, Marieke S. Tollenaar, Marcela Tamayo-Ortiz, Lauren E. Philbrook, Carolina De Weerth, Yang Cao, Joost Rotteveel, Rina D. Eiden, Rima Azar, Nicole R. Bush, Adina Chis, Grazyna Kmita, Melissa W. Clearfield, Roseriet Beijers, Michael Gröschl, Stefan A. Wudy, Andries Kalsbeek, Evalotte Mörelius, Martijn J.J. Finken

Research outputs 2022 to 2026

Context: In adults, cortisol levels show a pronounced 24-hour rhythm with a peak in the early morning. It is unknown at what age this early-morning peak in cortisol emerges during infancy, hampering the establishment of optimal dosing regimens for hydrocortisone replacement therapy in infants with an inborn form of adrenal insufficiency. Objective: We aimed to characterize daily variation in salivary cortisol concentration across the first year of life. Methods: We conducted a systematic review followed by an individual participant data meta-analysis of studies reporting on spontaneous (ie, not stress-induced) salivary cortisol concentrations in healthy infants aged 0-1 year. A one-stage …

Blast Tube Design: How Shape And Size Influence The Resultant Shock Wave, R. L. Bauer, C. E. Johnson

Mining Engineering Faculty Research & Creative Works

Shock tubes and tunnels are often used in research settings as a way of producing high pressure shock waves in a smaller footprint or without the use of explosives. However, there is no standard geometric design across laboratories. Peak pressure is a significant parameter for characterizing a shock wave. However, different tube configurations could also affect parameters such as impulse and duration, yet no research has investigated how the scale of the tube affects the overall waveform shape. To understand the implications of shock tube design, tubes with a constant length to diameter ratio were evaluated to determine how tube …

Exploring Key Factors Influencing Depressive Symptoms Among Middle-Aged And Elderly Adult Population: A Machine Learning-Based Method, Ngoc Doan Thu Tran, Yi Zhen Tan, Sapphire Lin, Fang Zhao, Yee Sien Ng, Dong Ma, Jeonggil Ko, Rajesh Krishna Balan

Research Collection School Of Computing and Information Systems

Objective: This paper aims to investigate the key factors, including demographics, socioeconomics, physical wellbeing, lifestyle, daily activities and loneliness that can impact depressive symptoms in the middle-aged and elderly population using machine learning techniques. By identifying the most important predictors of depressive symptoms through the analysis, the findings can have important implications for early depression detection and intervention. Participants: For our cross-sectional study, we recruited a total of 976 volunteers, with a specific focus on individuals aged 50 and above. Each participant was requested to provide their demographic, socioeconomic information and undergo several physical health tests. Additionally, they were asked …

Analytical Method For Solving Systems Of Fractional Initial Value Problems Using The Modified Atangana-Baleanu Derivative, Lana Mohammad Aref

Theses

This thesis presents an analytical method to solve systems of fractional initial value problems using the Modified Atangana-Baleanu Fractional Derivative. The proposed approach leverages an improved operational matrix method, incorporating an iterative, direct computation technique to simplify the solution process and reduce computational costs. Foundational concepts in fractional calculus and block pulse functions are introduced, followed by the derivation of operational matrices tailored for fractional systems. Theoretical analysis establishes the existence and uniqueness of solutions, along with uniform convergence and error estimates. Practical examples and applications are presented that demonstrate the efficiency, accuracy, and versatility of the method in solving …