Digital Commons Network^™

Molecular Classification Of Endometrial Cancers (Ec) And Association With Relapse-Free Survival (Rfs) And Overall Survival (Os) Outcomes: Ancillary Analysis Of Gog-0258, Aine Clements, Danielle Enserro, Kyle C Strickland, Rebecca Previs, Daniela Matei, David Mutch, Matthew Powell, Ann Klopp, David Scott Miller, William Small, Paul Disilvestro, Nick Spirtos, Casey Cosgrove, Greg Sfakianos, J Rebecca Liu, Roberto Vargas, Mark Shahin, Bradley Corr, Kimberly Dessources, Frederick Ueland, David Warshal, Jessica Gillen, Angeles Alvarez Secord

Faculty, Staff and Student Publications

Purpose: Determine if molecular classification using mismatch repair (MMR) and p53 protein expression predicts recurrence-free survival (RFS) and overall survival (OS) in endometrial cancer (EC) patients treated with chemotherapy and radiation (CRT) versus chemotherapy (CT).

Methods: GOG-0258, a phase III randomized trial (NCT00942357), compared CRT to CT. Immunohistochemistry assessed MMR and p53 status. Kaplan-Meier curves and adjusted Cox models analyzed survival outcomes by molecular subtype.

Results: ECs classified as deficient MMR (dMMR) (27 %), p53 abnormal (p53abn) (24 %), and p53 wild type (p53wt) (49 %). p53abn were more frequent in patients that were older, Black, and had …

A Multicenter Open-Label Randomized Phase Ii Study Of Osimertinib With And Without Ramucirumab In Tyrosine Kinase Inhibitor–Naïve Egfr-Mutant Metastatic Non–Small Cell Lung Cancer (Ramose Trial), Xiuning Le, Jyoti D Patel, Elaine Shum, Christina Baik, Rachel E Sanborn, Catherine A Shu, Chul Kim, Mary Jo Fidler, Richard Hall, Yasir Y Elamin, Janet Tu, George Blumenschein, Jianjun Zhang, Don Gibbons, Carl Gay, Nisha A Mohindra, Young Chae, Yanis Boumber, Joshua Sabari, Rafael Santana-Davila, Shane Rogosin, Benjamin Herzberg, Ben Creelan, Bruna Pellini, Tawee Tanvetyanon, Simon Heeke, Mike Hernandez, Jhanelle E Gray, Andreas Saltos, John V Heymach

Faculty, Staff and Student Publications

Purpose: Preclinical studies demonstrated that dual inhibition of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) pathways delay the emergence of resistance to EGFR tyrosine kinase inhibitors (TKIs), and in trials with first-generation EGFR TKIs, the combination of EGFR VEGF pathway inhibitors prolonged progression-free survival (PFS).

Methods: The RAMOSE trial (ClinicalTrials.gov identifier: NCT03909334, HCRN LUN-18-335) is a randomized, open-label multicenter phase II study comparing osimertinib with ramucirumab (arm A) to osimertinib (arm B) for initial treatment of metastatic EGFR-mutant non-small cell lung cancer (NSCLC) with 2:1 random assignment. The primary end point is PFS for …

Decoding Cancer Etiology With Cellular Reprogramming, Mo-Fan Huang, Megan E Fisher, Trinh T T Phan, Ruiying Zhao, Dung-Fang Lee

Faculty, Staff and Student Publications

Cancer research remains clinically unmet in many areas due to limited access to patient samples and the lack of reliable model systems that truly reflect human cancer biology. The emergence of patient-derived induced pluripotent stem cells and engineered human pluripotent stem cells (hPSCs) has helped overcome these challenges, offering a versatile alternative platform for advancing cancer research. These hPSCs are already proving to be valuable models for studying specific cancer driver mutations, offering insights into cancer origins, pathogenesis, tumor heterogeneity, clonal evolution, and facilitating drug discovery and testing. This article reviews recent progress in utilizing hPSCs for clinically relevant cancer …

Chemoresistance-Motility Signature Of Molecular Evolution To Chemotherapy In Non-Muscle-Invasive Bladder Cancer And Its Clinical Implications, Mi-So Jeong, Seung-Woo Baek, Gi-Eun Yang, Jeong-Yeon Mun, Jeong Ah Kim, Tae-Nam Kim, Jong-Kil Nam, Yung-Hyun Choi, Ju-Seog Lee, In-Sun Chu, Sun-Hee Leem

Faculty, Staff and Student Publications

Non-muscle-invasive bladder cancer (NMIBC) often recurs and can progress to MIBC due to resistance to treatments like intravesical chemotherapy or Bacillus Calmette-Guérin (BCG). Therefore, we established the Gemcitabine-Resistant Cells (GRCs) to study the molecular evolution under external pressure. A 63-gene Chemoresistance-Motility (CrM) signature was created to identify stage-specific traits of GRCs. This signature was tested on 1846 samples using log-rank tests and Cox regression to evaluate clinical utility. Early and intermediate resistance stages showed increased cell motility and metastatic potential. FAK, PI3K-AKT, and TGFβ pathways were activated first, followed by MAPK signaling. Single-cell analysis and experiments utilizing the CrM signature …

Selinexor (Kpt-330) In Combination With Immune Checkpoint Inhibition In Uveal Melanoma: A Phase 1b Trial, Mohamed A Gouda, Abdulrazzak Zarifa, Yali Yang, Bettzy Stephen, Serdar A Gurses, Ashabari Sprenger, Yanyan Tian, Mohamed H Derbala, Isabella Glitza Oliva, Funda Meric-Bernstam, Sapna P Patel

Faculty, Staff and Student Publications

Introduction: Uveal melanoma remains a disease with aggressive behavior and poor prognosis despite advances in clinical management. Because monotherapy with immune checkpoint inhibitors has led to limited improvement in response rates, combination with other agents that act on the biological basis of oncogenesis has been proposed as a possible therapeutic strategy.

Methods: We designed a phase 1b trial to test the safety and tolerability of selinexor in combination with immune checkpoint inhibitors in patients with advanced uveal melanoma. Patients received selinexor 60 mg PO twice weekly with standard of care, commercially available immune checkpoint inhibitor of the investigator's choice. In …

Offshore Wind Farms Could Impact Coastal Marine Heatwaves In Eastern Boundary Upwelling Systems, Michael Dalsin, Ryan K. Walter, Piero L.F. Mazzini

Physics

Analysis of ecosystem impacts from offshore wind (OSW) farm development has primarily focused on localized effects. However, in Eastern Boundary Current Upwelling Systems (EBUS) like the California Current, OSW farms can modify the intensity and spatial structure of wind-driven upwelling, inducing non-local (tens of kms away) changes to seawater temperature. Recent numerical modeling research determined that a hypothetical upper bound full buildout of OSW farms in central California could warm coastal waters through a reduction in upwelling. Here, we examine the sensitivity of coastal marine heatwaves (MHWs), which are prolonged extreme seawater temperatures that are among the greatest threats to …

Brain Transcriptomics Of A Social Challenge And Maternal Aggression In Incubating Female Tree Swallows, Emily J. Levy, Elizabeth M. George, Douglas B. Rusch, Aaron Buechlein, Kimberly A. Rosvall

Biology Faculty Publications

Aggressive behavior is ubiquitous across many contexts, including defense of territories, mates, and offspring. For decades, researchers have detailed the effect of aggressive behavior on physiology, but our understanding of these mechanisms in females lags behind that of males, despite the fact that female aggression is widespread, particularly in the context of maternal defense of eggs or offspring (i.e., maternal aggression). Here, we measured effects of a social challenge on brain gene expression in free-living incubating females. We hypothesized that the social challenge would generate at least one of three transcriptomic effects: (1) sensitizing the brain to otherwise low levels …

Host Traits And Temperature Predict Biogeographical Variation In Seagrass Disease Prevalence, F.R. Schenck, J.K. Baum, K.E. Boyer, J.E. Duffy, F.J. Fodrie, J. Gaeckle, Torrie Hanley, C.M. Hereu, K.A. Hovel, P. Jorgensen, D.L. Martin, N.E. O’Connor, B.J. Peterson, J.J. Stachowicz, A.R. Hughes

Biology Faculty Publications

Diseases are ubiquitous in natural systems, with broad effects across populations, communities and ecosystems. However, the drivers of many diseases remain poorly understood, particularly in marine environments, inhibiting effective conservation and management measures. We examined biogeographical patterns of infection in the foundational seagrass Zostera marina by the parasitic protist Labyrinthula zosterae, the causative agent of seagrass wasting disease, across >20° of latitude in two ocean basins. We then identified and characterized relationships among wasting disease prevalence and a suite of host traits and environmental variables. Host characteristics and transmission dynamics explained most of the variance in prevalence across our survey, …

Empowering Multilingual Learners Through Culturally Sustaining Pedagogy And Arts-Based Learning In Burkina Faso, Inoussa Malgoubri

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This dissertation explores how culturally sustaining pedagogy and arts-based learning can engage multilingual learners of English as an Additional Language (EAL) in Burkina Faso. The research emphasizes the incorporation of local cultural elements and learners' linguistic backgrounds into the EAL curriculum to address challenges such as limited classroom interactions (Somé-Guiebré, 2020) and monolingual instructional strategies with inadequate cultural representation (Ndlangamandla, 2024). This qualitative study integrates culturally relevant materials, including Forum Theater, slam poetry, and griot-style storytelling, to create an engaging and inclusive learning environment. Data consisted of observation, images from arts-based workshops and pre- and post-workshop interviews with selected teachers …

Survival By Selection: The Role Of Natural Selection In Developing Biological Radiation Defenses, Seyed Alireza Mortazavi, Ilham Said-Salman, Sami El Khatib, Parmis Taghizadeh, Seyed Mohammad Javad Mortazavi, Lembit Sihver

Informatics and Engineering Systems Faculty Publications

Natural selection, a cornerstone of evolutionary biology, shapes the adaptations organisms develop to survive environmental pressures. This paper explores how natural selection drives biological adaptations to radiation exposure. We examine the genetic mechanisms at play, exemplified by the enhanced DNA repair capabilities observed in bacteria like Escherichia coli (E. coli) following exposure to radiation. We then investigate adaptations in humans residing in high-background radiation areas, highlighting potential genetic variations for radiation resistance. Finally, the contemporary relevance of natural selection is discussed, emphasizing its role in the emergence of antibiotic-resistant bacteria and the need for sustainable medical practices. By studying these …

A Randomized, Double-Blind, Placebo-Controlled Trial Of Daxibotulinumtoxina For Injection For The Treatment Of Upper Limb Spasticity In Adults After Stroke Or Traumatic Brain Injury, Atul T Patel, Michael C Munin, Ziyad Ayyoub, Gerard E Francisco, Rashid Kazerooni, Todd M Gross

Faculty, Staff and Student Publications

Background: Intramuscular injection of botulinum toxin type A is a first-line pharmacotherapy for adults with upper limb spasticity (ULS). However, reemergence of symptoms within 12 weeks of treatment is common and longer-lasting treatments are needed.

Objective: To evaluate the efficacy and safety of three doses of DaxibotulinumtoxinA for Injection (DAXI) for treatment of ULS in adults with stroke or traumatic brain injury.

Intervention: Intramuscular injections of placebo (N = 24), DAXI 250 U (N = 22), DAXI 375 U (N = 19), or DAXI 500 U (N = 18) to the suprahypertonic muscle (SMG) and other muscle groups.

Design: Randomized, …

Survey Of Vitamin D Supplementation Practices In Extremely Preterm Infants, Mar Romero-Lopez, Mamta Naik, Lindsay F Holzapfel, Ariel A Salas, Kaashif A Ahmad, Matthew A Rysavy, Waldemar A Carlo, Yuxin Zhang, Covi Tibe, Jon E Tyson

Faculty, Staff and Student Publications

Background: Most extremely preterm (EP) infants are vitamin D deficient (serum 25-hydroxyvitamin D levels below 20 ng/mL), and optimal supplementation practices for EP infants remain unknown. Our objective is to assess current vitamin D supplementation practices in U.S. neonatal intensive care units (NICU) for EP infants to provide baseline information for the design of future clinical trials.

Methods: We conducted an online survey to study vitamin D intake and supplementation practices in U.S. NICUs caring for EP infants. Descriptive statistics compared responses by affiliation and level of care.

Results: We analyzed responses from 253 NICUs, representing the majority of academic …

Improving The Prediction Accuracy Of A Model Using Svr With Genetic Algorithm, Rand Haitham Abdul Hussein, Suhail Najm Abdulla

Journal of Economics and Administrative Sciences

The enhancement of predictive accuracy of the first-order integer autoregressive (INAR 1) model is the focus of the study through the effective amalgam of machine learning techniques and classical statistics. INAR (1) model structures are key elements for the prediction of nonnegative integer-valued time series processes. Conventional estimation methods include Classical Least Squares (CLS), Conditional Maximum Likelihood (CML), and Yule-Walker (YW) as compared with advanced methods like Support Vector Regression (SVR) and Genetic Algorithms (GA). A new clustering algorithm was created (with SVR to GA) to determine optimal INAR (1) model parameters. Computer simulation studies confirmed the effectiveness of the …

The End Of Fda Exceptionalism? Dissecting Deference To The Fda In Drug Disputes, Anjali Deshmukh

Cardozo Law Review

On April 7, 2023, a federal judge issued a nationwide stay on the United States Food and Drug Administration (FDA) approval of the abortifacient medication mifepristone. It was instantly a landmark case, decried as the first time in over one-hundred years that a federal court nullified an FDA drug approval. A few hours later, a second federal district court enjoined FDA restrictions on mifepristone. Two federal courts substantively evaluating FDA drug approval data in one day is unprecedented. It begs the question: will courts overturn FDA drug approvals again?

Conventional wisdom says no. Abortion exceptionalism, the trend of legislatures and …

Comparing Methods For Estimating Gamma Distribution Parameters With Outliers Observation, Taha Hussein Ali, Dlshad Mahmood Saleh, Qais Mustafa Abdulqader, Awaz Omer Ahmed

Journal of Economics and Administrative Sciences

The purpose of our research is to work to maintain parameters for the Gamma Distribution within a better frame of precision in the context of other methods and dealing with outliers. Outliers are common and pose a threat to modelling because one little outlier scales a statistical model and brings about the estimations of parametric index validity. The objective of this study was to find useful applications for the detection and mitigating effect of outliers accomplished through the Hampel filter, the nonlinear fit of the Gamma distribution using the Median Rank Regression (MRR) method for the calculation of the shape …

Effective Business Promotion Strategies Small Business Owners Use To Improve Revenue And Increase Business Viability, Shirley Owusu-Ankomah

Walden Dissertations and Doctoral Studies

Small businesses are vital to national and local economies, yet many struggle to sustain operations in the long term. A significant concern for small business owners is the lack of effective promotion strategies, a key factor in business failure. Grounded in open system theory, the purpose of this multiple case study was to investigate the promotion strategies employed by small business owners to improve revenue and increase business viability. The participants were six small business owners from Sekondi-Takoradi in Ghana’s Western Region, who successfully utilized strategies to improve revenue and maintain their businesses. Data sources included semistructured interview data and …

Effective Business Promotion Strategies Small Business Owners Use To Improve Revenue And Increase Business Viability, Shirley Owusu-Ankomah

Walden Dissertations and Doctoral Studies

Small businesses are vital to national and local economies, yet many struggle to sustain operations in the long term. A significant concern for small business owners is the lack of effective promotion strategies, a key factor in business failure. Grounded in open system theory, the purpose of this multiple case study was to investigate the promotion strategies employed by small business owners to improve revenue and increase business viability. The participants were six small business owners from Sekondi-Takoradi in Ghana’s Western Region, who successfully utilized strategies to improve revenue and maintain their businesses. Data sources included semistructured interview data and …

Selling Homemade Food Products In New Hampshire The Basics - Part Two [Fact Sheet], Mary S. Choate

UNH Cooperative Extension

No abstract provided.

Struggles Around Transgenderism In Hungarian Feminism: An Autoethnographic Account, Dalma Feró

Dignity: A Journal of Analysis of Exploitation and Violence

In this autoethnography, I am using my personal experiences as data to examine the inextricable personal, political, social, and cultural aspects of one of the most decisive ruptures in Hungarian “progressive” activism of the second half of the 2010s. In the mid-2010s, I was part of an informal collective of women that started to outline a feminist approach critical of mainstream individualistic renditions of women’s rights as social progress, thereby diverging fundamentally from the country’s institutionalised feminism. As I and the circle of women I worked with focused on women’s reproductive autonomy, we encountered central feminist questions about sex and …

A Reconstruction Of Gender: Implications Of Social Construct And Gender Structure Theories, Bethany Rozario Steinhagen

Dignity: A Journal of Analysis of Exploitation and Violence

The relationship between gender and social construction has long been discussed in feminist and gender studies scholarship. However, the current discussion on gender has run up against a blockage of misapplication of social construct theory. To untangle this blockage, my analysis applies the philosophy of social construction as explained by Ian Hacking in his 1999 book The Social Construction of What? and the framework of gender as a social structure as put forth by feminist sociologist Barbara Risman since the early 2000s. I apply these frameworks to elucidate better the logical implications that follow from a social construct thesis about …

Response To A Political Critique And Personal Attack Against A United Nations Report That Presented New Evidence About Prostitution As A Cause And Consequence Of Violence Against Women And Girls, Reem Alsalem

Dignity: A Journal of Analysis of Exploitation and Violence

Reem Alsalem, the United Nations Special Rapporteur on the Elimination of Violence Against Women and Girls, Its Causes and Consequences, responses to the false and unfounded accusations and personal attacks on her Report on Prostitution and Violence Against Women presented before the 56^th session of the United Nations Human Rights Council in Geneva, 2024. I presented new evidence regarding the relationship between violence against women and girls and prostitution. Using human rights law, the Report described how prostitution is a system of abuse, exploitation, and violence against women and girls. The Report’s goal was to clarify concepts and terminology, …

Respuesta A Una Crítica Política Y A Un Ataque Personal Contra Un Informe De Las Naciones Unidas Que Presenta Nueva Evidencia Sobre La Prostitución Como Causa Y Consecuencia De La Violencia Contra Las Mujeres Y Las Niñas, Reem Alsalem

Dignity: A Journal of Analysis of Exploitation and Violence

Reem Alsalem, Relatora Especial de las Naciones Unidas sobre la violencia contra las mujeres y las niñas, sus causas y consecuencias, responde a las acusaciones falsas y infundadas y a los ataques personales sobre su informe sobre Prostitución y Violencia contra la Mujer, presentado ante la 56ª sesión del Consejo de Derechos Humanos de las Naciones Unidas en Ginebra, 2024. Presenté nueva evidencia sobre la relación entre la violencia contra las mujeres y las niñas y la prostitución. Utilizando el derecho de los derechos humanos, el informe describe la prostitución como un sistema de abuso, explotación y violencia contra las …

Protein Arginine Methyltransferases As Regulators Of Cellular Stress, Julia Zaccarelli-Magalhães, Cristiane Teresinha Citadin, Julia Langman, Drew James Smith, Luiz Henrique Matuguma, Hung Wen Lin, Mariana Sayuri Berto Udo

Faculty, Staff and Student Publications

Arginine modification can be a "switch" to regulate DNA transcription and a post-translational modification via methylation of a variety of cellular targets involved in signal transduction, gene transcription, DNA repair, and mRNA alterations. This consequently can turn downstream biological effectors "on" and "off". Arginine methylation is catalyzed by protein arginine methyltransferases (PRMTs 1-9) in both the nucleus and cytoplasm, and is thought to be involved in many disease processes. However, PRMTs have not been well-documented in the brain and their function as it relates to metabolism, circulation, functional learning and memory are understudied. In this review, we provide a comprehensive …

Management Of Isolated Partial Acl Tears: A Survey Of International Acl Surgeons, Christopher S Frey, Kinsley J Pierre, Nicole S Pham, Geoffrey D Abrams, Seth L Sherman, Tim Spalding, Marc R Safran

Faculty, Staff and Student Publications

Background: Partial anterior cruciate ligament (ACL) tears, particularly injuries detected with magnetic resonance imaging (MRI) but stable on ligamentous examination, appear to be recognized more frequently; however, there remains no consensus management for this complex pathology.

Purpose: To present the results of a survey of a group of international ACL experts on the management of partial ACL injuries.

Study design: Survey study; Level of evidence, 5.

Methods: The ACL Study Group is an international group of orthopaedic surgeons with a special interest in the ACL. There are 169 members overall, with 135 clinically active surgeons. A branching logic survey was …

Applications Of Metabolomics And Lipidomics In The Neonatal Intensive Care Unit, Jonathan D Reiss, Samson J Mataraso, Lindsay F Holzapfel, Ivana Marić, Maya M Kasowski, Camilia R Martin, Jonathan Z Long, David K Stevenson, Gary M Shaw

Faculty, Staff and Student Publications

The metabolome and lipidome comprise the thousands of molecular compounds in an organism. Molecular compounds consist of the upstream metabolic components of intracellular reactions or the byproducts of cellular pathways. Molecular and biochemical perturbations are associated with disorders in newborns and infants. The diagnosis of inborn errors of metabolism has relied on targeted metabolomics for several decades. Newer approaches offer the potential to identify novel biomarkers for common diseases of the newborn and infant. They may also elucidate novel predictive or diagnostic measures for a variety of health trajectories. Here, we review the relevance of the metabolome and lipidome for …

Pharmacologic Management Of Heart Failure With Preserved Ejection Fraction (Hfpef) In Older Adults, Ashkan Hashemi, Min Ji Kwak, Parag Goyal

Faculty, Staff and Student Publications

There are several pharmacologic agents that have been touted as guideline-directed medical therapy for heart failure with preserved ejection fraction (HFpEF). However, it is important to recognize that older adults with HFpEF also contend with an increased risk for adverse effects from medications due to age-related changes in pharmacokinetics and pharmacodynamics of medications, as well as the concurrence of geriatric conditions such as polypharmacy and frailty. With this review, we discuss the underlying evidence for the benefits of various treatments in HFpEF and incorporate key considerations for older adults, a subpopulation that may be at higher risk for adverse drug …

Exploring Unintended Consequences From The Prospective Payment System Transitional Drug Add-On Payment Adjustment To Refine Program Enhancement Strategies, Donald Andrew Molony, Dia Rose Waguespack

Faculty, Staff and Student Publications

No abstract provided.

Conflicted Help-Seeking: Vulnerable And Grandiose Narcissistic Traits In College Students, Daniel G. Lannin, Rachel Brenner, Jake R. Solka, Amanda Martin, Anthony Hermann

Faculty Publications – Psychology

This study highlights distinct patterns in help-seeking behavior among college students with narcissistic traits, focusing on grandiose and vulnerable manifestations of these traits. Two undergraduate samples (N₁ = 398, N₂ = 424) completed measures of narcissistic traits, stigma, psychological distress, and help-seeking intentions. Higher levels of vulnerable narcissistic traits were positively linked to help-seeking willingness, with indirect effects through heightened distress (positive) and stigma (negative). In contrast, grandiose narcissistic traits showed no consistent direct or indirect effects on help-seeking behavior. These findings reveal that students with elevated vulnerable narcissistic traits may experience conflicting motivations for seeking help – driven by …

Genome Wide Association Study Reveals Novel Associations With Face Morphology, Aamer Alshehhi, Mira Mousa, Guan K. Tay, Naoufel Werghi, Habiba Alsafar

Research outputs 2022 to 2026

Genome-wide association studies (GWAS) on the Middle Eastern population, including the United Arab Emirates (UAE), have been relatively limited. The present study aims to investigate genotype-face morphology associations in the UAE population through Genome Wide Association Studies (GWAS). Phenotypic data (44 face measurements) from 172 Emiratis was obtained through three-dimensional (3D) scanning technology and an automatic face landmarking technique. GWAS analysis revealed associations of 19 genetic loci with six face features, 14 of which are novel. The GWAS analysis revealed 11 significant relationships between 44 face parameters and 242 SNPs, exceeding the GWAS significance threshold. These phenotypes were previously associated …

Investigating The Impact Of Sorghum On Tau Protein Phosphorylation And Mitochondrial Dysfunction Modulation In Alzheimer’S Disease: An In Vitro Study, Nasim Rezaee, Eugene Hone, Hamid Sohrabi, Rasheed Abdulraheem, Stuart K. Johnson, Stuart Gunzburg, Ralph N. Martins, W. M.A.D.Binosha Fernando

Research outputs 2022 to 2026

Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with poorly understood pathology. Elevated tau, phospho-tau and mitochondrial dysfunction are significantly correlated with an increased risk of AD and are therefore targets for disease-modifying therapy. In this study, we examined the effects of polyphenolic extracts from six different varieties of sorghum: Shawaya short black-1 (Black), IS1311C (Brown), QL33/QL36 (Red), B923296 (Red), QL12 (White), and QL33 (Red) on the attenuation of beta amyloid-induced phospho-tau levels, total tau levels, and mitochondrial dysfunction in neuronal cells. Method: Tau proteins (231 (pT231), Serine- 199 (pS199), and total tau proteins (T-tau)) were detected and quantified …