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Unlocking Nature’S Ice-Binders, Nicholas Gosling

UNH Today Archive

No abstract provided.

A Comparison Study Of Sensory Processing In Older Adults With And Without Dementia, Medi̇ne Nur Özata Değerli̇, Di̇dem Karaduman, Burcu Balam Doğu, Onur Altuntaş

Turkish Journal of Medical Sciences

Background/aim: Sensory processing is affected by aging, and dementia may lead to changes in sensory processing. This study aimed to examine the differences in sensory processing and sensory modulation between older adults with and without dementia.Materials and methods: This study was designed as a comparative study of community-dwelling older adults aged 65 years and older with and without dementia. Participants and their caregivers were recruited at the occupational therapy clinic of a public hospital. They completed a sociodemographic information form and the Adolescent/Adult Sensory Profile to assess sensory processing and sensory modulation.Results: The study included 120 older adults (60 with …

Nanrilkefusp Alfa (Sot101), An Il-15 Receptor Βγ Superagonist, As A Single Agent Or With Anti-Pd-1 In Patients With Advanced Cancers, Stephane Champiat, Elena Garralda, Vladimir Galvao, Philippe A Cassier, Carlos Gomez-Roca, Iphigenie Korakis, Peter Grell, Aung Naing, Patricia Lorusso, Romana Mikyskova, Nada Podzimkova, Milan Reinis, Kaissa Ouali, Andreu Schoenenberger, Joachim Kiemle-Kallee, Sascha Tillmanns, Richard Sachse, Ulrich Moebius, Radek Spisek, David Bechard, Lenka Palova Jelinkova, Irena Adkins, Aurelien Marabelle

Faculty, Staff and Student Publications

Nanrilkefusp alfa (nanril; SOT101) is an interleukin (IL)-15 receptor βγ superagonist that stimulates natural killer (NK) and CD8

Single-Cell Analysis Of Neoplastic Plasma Cells Identifies Myeloma Pathobiology Mediators And Potential Targets, Luz Yurany Moreno Rueda, Hua Wang, Keiko Akagi, Minghao Dang, Amishi Vora, Li Qin, Hans C Lee, Krina K Patel, Pei Lin, David E Mery, Fenghuang Zhan, John D Shaughnessy, Qing Yi, Yang Song, Bo Jiang, Maura L Gillison, Sheeba K Thomas, Donna M Weber, Lixia Diao, Jing Wang, Isere Kuiatse, Elisabet E Manasanch, David E Symer, Robert Z Orlowski

Faculty, Staff and Student Publications

Multiple myeloma is a clonal plasma cell (PC) dyscrasia that arises from precursors and has been studied utilizing approaches focused on CD138+ cells. By combining single-cell RNA sequencing (scRNA-seq) with scB-cell receptor sequencing (scBCR-seq), we differentiate monoclonal/neoplastic from polyclonal/normal PCs and find more dysregulated genes, especially in precursor patients, than we would have by analyzing bulk PCs. To determine whether this approach can identify oncogenes that contribute to disease pathobiology, mitotic arrest deficient-2 like-1 (MAD2L1) and S-adenosylmethionine synthase isoform type-2 (MAT2A) are validated as targets with drug-like molecules that suppress myeloma growth in preclinical models. Moreover, functional studies show a …

An Integrative Multiparametric Approach Stratifies Putative Distinct Phenotypes Of Blast Phase Chronic Myelomonocytic Leukemia, Kristian Gurashi, Yu-Hung Wang, Fabio M R Amaral, Katherine Spence, Rachel Cant, Chi-Yuan Yao, Chien-Chin Lin, Christopher Wirth, David C Wedge, Guillermo Montalban-Bravo, Simona Colla, Hwei-Fang Tien, Tim C P Somervaille, Kiran Batta, Daniel H Wiseman

Faculty, Staff and Student Publications

Approximately 30% of patients with chronic myelomonocytic leukemia (CMML) undergo transformation to a chemo-refractory blastic phase (BP-CMML). Seeking novel therapeutic approaches, we profiled blast transcriptomes from 42 BP-CMMLs, observing extensive transcriptional heterogeneity and poor alignment to current acute myeloid leukemia (AML) classifications. BP-CMMLs display distinctive transcriptomic profiles, including enrichment for quiescence and variability in drug response signatures. Integrating clinical, immunophenotype, and transcriptome parameters, Random Forest unsupervised clustering distinguishes immature and mature subtypes characterized by differential expression of transcriptional modules, oncogenes, apoptotic regulators, and patterns of surface marker expression. Subtypes differ in predicted response to AML drugs, validated ex vivo in …

Effects Of Differential Protein Removal On The Properties Of Early Indica Rice Flour, Cao Yijun, Feng Wei, Wang Ren, Zhang Hao, Wang Tao

Food and Machinery

［Objective ］ To investigate the mechanism of the effect of deproteinisation on the physicochemical and functional properties of rice flour.［Methods ］ Enzymatic and alkaline methods were used to remove protein from early rice flour,and the damaged starch content,size distribution,morphology,solubility,swelling power,pasting characteristics and textural characteristics of the deproteinized rice flour were analyzed.［Results］ Sodium dodecyl sulfate -polyacrylamide gel electrophoresis (SDS -PAGE ) and confocal laser scanning microscope (CLSM ) showed that the alkaline method equally removed the protein subunit where as the enzymatic method showed a better homogeneity of protein removal from the surface of starch.The size distribution of the control showed …

Effect And Synergy Of Different Exogenous Additives On Gel Properties Of The Crayfish Surimi Products, Fang Siwei, Yu Jinxiang, Guo Quanyou, Bao Hairong, Hu Huogen

Food and Machinery

［Objective ］ This study aimed to investigate the effect of exogenous additives on gel properties of crawfish surimi products.［Methods ］ The experiment was designed with different amounts of hydroxypropyl distarch phosphate (HPDSP ),soy protein isolate (SPI),and glutamine transaminase (TGase ).After clarifying the addition amounts of the above three exogenous additives (HPDSP,SPI,TGase ),the effects of the three additives alone and the combination of the three additives (HST ) on the gel strength,water distribution,rheological properties,protein secondary structure,and microstructure of crayfish surimi were clarified,respectively.［Results］ The results showed that the best gel characteristics of crayfish surimi were obtained when HPDSP,SPI,and TGase were added at …

Two-Dimensional Correlation Infrared Spectroscopy And Hyperspectral Imaging To Detect The Changes Of Polysaccharide During The Drying Process Of Polygonatum Sibiricum, Fu Shuya, Xie Anguo, Liu Yunhong

Food and Machinery

［Objective ］ To study the changes of polysaccharide in the drying process of "one steam and one preparation" of Polygonatum sibiricum.［Methods ］ The slices were steamed by atmospheric pressure water isolation steaming,and then dried by heat pump at 60 ℃.Near infrared spectroscopy (NIR ),hyperspectral imaging (HSI ) and middle and far infrared spectroscopy were used to analyze the characteristic spectra of the drying process of Polygonatum sibiricum,and the changes of polysaccharide during the drying process were studied by combining two -dimensional correlation infrared spectroscopy (2D-IR) analysis method.［Results］ The content of polysaccharide was 3.39% after steam heating for 11 h,and 6.67% …

Egg Appearance Quality Detection Based On Cnn-Svm Model, Qi Ge, Zhao Feng, Li Wanning

Food and Machinery

［Objective ］ In order to improve the accuracy of egg appearance quality detection,an egg appearance quality detection model based on CNN -SVM model was established.［Methods ］ Combined with the adaptive feature extraction capability of CNN and the super -generalization classification capability of SVM,the features of fully connected layers were extracted by six -layer convolutional neural network structure processing,and the CNN -SVM hybrid model was adopted,instead of the traditional CNN + softmax,an egg appearance quality detection method based on CNN -SVM model was proposed.［Results］ Compared with SVM model,CNN model and KNN model,CNN -SVM model had better performance in accuracy,precision,recall and F1 …

Study On The Inhibitory Mechanism Of Epigallocatechin Gallate Against Foodborne Pathogens And Its Application, Chen Xiaomin, Huang Zexuan, Tan Lihao, Yu Yigang

Food and Machinery

［Objective ］ The bacteriostatic mechanism of epigallocatechin gallate (EGCG ) against Staphylococcus aureus (S.aureus ) and Salmonella typhimurium (S.typhimurium ) and the elimination effect of S.aureus and S.typhimurium in purple yam chip were studied.［Methods ］ The bacteriostatic effect of EGCG in vitro was determined by microbroth gradient dilution method,and the bacteriostatic mechanism of EGCG was further determined by potassium ion determination,PI staining,OD260 nm value,OD280 nm value and cell morphology observation.Finally,the clearance rate of S.aureus and S.typhimurium in purple yam chip was studied by EGCG combined with pasteurization.［Results］ The minimum inhibitory concentration (MIC ) of EGCG for S.aureus and S.typhimurium was …

Research Progress On Application Of Dextran In Food, Chang Guowei, Li Zhide, Liu Guiyun, Liang Dafeng, Huang Zengwei

Food and Machinery

Dextran is a kind of microbial polysaccharide consisting of a glucose chain linked by α-1,6-glucoside bond.Its application research has been carried out in many food fields.In this review,the structure and function analysis of new sources of dextran and the research trend of producing bacteria in recent years were summarized,and the research status of innovative applications of dextran in the field of protein deep processing,bread baking,prebiotics,etc.,were described.The existing problems in current research and policy and future research directions were also discussed.

Application Of Quantum Dot Immunochromatography In Rapid Detection Of Veterinary Drug Residues, Song Qianzhao, Wang Yao, Hu Xiaofei, Cao Li, Sun Yaning

Food and Machinery

In recent years,immunochromatography has been a key player in the field of rapid detection of food of animal origin,providing a strong guarantee for the efficient supervision of veterinary drug residues.As a new type of fluorescent material,quantum dots can be used as a marker material in immunochromatographic detection,which can effectively improve the detection performance and has broad application prospects in the research field of rapid detection technology.This paper summarized the classification,synthesis,and preparation of immune probes of quantum dots,reviewed the application of quantum dot -based immunochromatographic assay in the rapid detection of veterinary drug residues in animal -derived food,prospected the research of …

Research And Development Of Food 3d Printing Based On Potato Starch And Potato Puree, Xia Guofeng, Ou Shengyang, Zhou Zhongyuan, Tao Lilulu, Lin Dongqi

Food and Machinery

As a staple food material,potatoes are rich in a variety of nutrients,which play an important role in regulating the dietary nutritional structure of residents.The article reviews the research on food 3D printing technology based on potato starch and potato puree,mainly including the research on food 3D printing technology based on potato starch.The study of food 3D printing performance under the condition of potato starch as the main material and additive,and the study of the influence of food additives and printing temperature on food 3D printing performance.Research on food 3D printing technology based on potato puree,including the effects of pretreatment methods,additives,printing …

Current Status Of Research On Golden Pomfret Processing And High-Value Utilization Of By-Products, Tu Yuchen, Lin Haisheng, Gao Jialong, Zhong Saiyi

Food and Machinery

Trachinotus ovatus is one of the main marine economic fish species in the South China sea,which is delicious and with high nutritional value.With the rapid development of culture technology,the output of golden pomfret is increasing in recent years.Its healthy circulation,fresh preservation and deep processing are of great significance to the healthy and sustainable development of the industry.This review summarized the current status of comprehensive processing and utilization technology of T.ovatus,including keep alive technology,low temperature preservation technology,non thermal processing technology,surimi processing technology,canning technology,pickling and smoking processing technology,and high value processing products of golden pomfret protein,prepared food,and high -value utilization of by …

Advances In Extraction Methods Of Astaxanthin From Crustacean Aquatic Products And Their Processing By-Products, Han Lu, Xiang Dandan, Xie Dan, Ma Zibin, Wu Chunhui

Food and Machinery

Astaxanthin is widely used in food,feed,cosmetic and pharmaceutical fields due to its biological activity and color characteristics,among which natural astaxanthin has a huge market demand in recent years due to its higher antioxidant activity and safety.In this review,the extraction methods of natural astaxanthin from crustacean aquatic products were summarized,including pretreatment as well as specific extraction techniques,such as oil solubilization,organic solvent method,supercritical fluid extraction,emerging ionic liquid method and deep eutectic solvent method.Moreover,the current problems in the extraction of natural astaxanthin were analyzed and the future research direction was pointed out.

Effects Of Vitamin D Replacement Combined With Graves’ Disease Therapy: A Retrospective Cohort Study, Beyza Taşkent Sezgi̇n, Muhammed Kizilgül, Özgür Özçeli̇k, Taner Demi̇rci̇, Hayri̇ Bostan, Ümran Gül, Beki̇r Uçan

Turkish Journal of Medical Sciences

Background/aim: In Graves’ disease (GD), an autoimmune disease, antibodies targeting the TSH receptor cause the production of excessive amounts of thyroid hormone. A significant association has been reported between low 25(OH) Vitamin D3 (VitD) levels and various autoimmune disorders. Therefore, this study aimed to investigate the effects of VitD deficiency and replacement therapy on laboratory and clinical parameters in GD patients.Methods:Fourty GD and 37 healthy control patients were included in this study. Patients with GD were divided into two groups, and the first group was given only antithyroid treatment (n:18), and the second group was given antithyroid treatment plus VitD …

Does Cd47 Expression Have Prognostic Significance In Classical Hodgkin Lymphoma?, Aydan Kiliçarslan, Gülnaz Kurt Çevi̇k, Mehmet Doğan, Ayşegül Aksoy Altinboğa, Funda Ceran, Şule Mi̇ne Bakanay Öztürk, Gülşah Efeci̇k

Turkish Journal of Medical Sciences

Background/aimHodgkin Lymphoma (HL) is highly treatable, but new chemotherapy agents are needed for patients with progression or recurrence. CD47 regulates anti-phagocytic activity by signaling through the SIRPα (signal regulatory protein alpha) pathway on macrophages. This study aims to assess the expression of CD47 in HL cases and explore its relationship with Epstein-Barr Virus (EBV) status and the International Prognostic Index (IPI).Materials and Methods120 patients diagnosed with Classical HL, characterized by the presence of Hodgkin and Reed-Sternberg (HRS) cells, for whom IPI scores were available. Demographic data and EBV status were retrieved from hospital records. CD47 immunohistochemical expression in HRS cells …

Relationship Between Uncoupling Protein 1 (Ucp1) Levels And Psoriasis, Fi̇kret Akyurek, Fatma Tuncez Akyurek, Fatma Sengul

Turkish Journal of Medical Sciences

Background/aim: Psoriasis is an autoimmune, chronic and common skin disease. Comorbidities also increase the mortality risk of the disease. The aim of this study is to investigate the changes in UCP1 levels in psoriasis patients and to evaluate their possible role in the pathogenesis of the disease, focusing on disease severity (Psoriasis Area and Severity Index), dyslipidemia, inflammation and cardiovascular risk.Materials and methods: This study included 30 psoriasis patients and 30 healthy individuals as a control group. Serum UCP1 was measured using an ELISA test kit. The laboratory results of psoriasis patients and healthy controls were compared.Results: UCP1 level was …

Redefining Cell Culture Using A 3d Flipwell Co-Culture System: A Mimetic For Gut Architecture And Dynamics In Vitro, Saori Furuta

Faculty Scholarship

Gut mucosae are composed of stratified layers of microbes, a selectively permeable mucus, an epithelial lining, and connective tissue homing immune cells. Studying cellular and chemical interactions between the gut mucosal components has been limited without a good model system. We have engineered a three-dimensional (3D) multi-cellular co-culture system we coined “3D Flipwell system” using cell culture inserts stacked against each other. This system allows an assessment of the impact of a gut mucosal environmental change on interactions between gut bacteria, epithelia, and immune cells. As such, this system can be utilized in examining the effects of exogenous stimuli, such …

Natural And Bioengineered Extracellular Vesicles In Diagnosis, Monitoring And Treatment Of Cancer, Xin Luo, Kathleen M Mcandrews, Raghu Kalluri

Faculty, Staff and Student Publications

Extracellular vesicles (EVs) are cell derived nanovesicles which are implicated in both physiological and pathological intercellular communication, including the initiation, progression, and metastasis of cancer. The exchange of biomolecules between stromal cells and cancer cells via EVs can provide a window to monitor cancer development in real time for better diagnostic and interventional strategies. In addition, the process of secretion and internalization of EVs by stromal and cancer cells in the tumor microenvironment (TME) can be exploited for delivering therapeutics. EVs have the potential to provide a targeted, biocompatible, and efficient delivery platform for the treatment of cancer and other …

Mitochondrial Defects And Metabolic Vulnerabilities In Lynch Syndrome-Associated Msh2-Deficient Endometrial Cancer, Mikayla Borthwick Bowen, Brenda Melendez, Qian Zhang, Diana Moreno, Leah Peralta, Wai Kin Chan, Collene Jeter, Lin Tan, M Anna Zal, Philip L Lorenzi, Kenneth Dunner, Richard K Yang, Russell R Broaddus, Joseph Celestino, Nisha Gokul, Elizabeth Whitley, Deena M Scoville, Tae Hoon Kim, Jae-Wook Jeong, Rosemarie Schmandt, Karen Lu, Hyun-Eui Kim, Melinda S Yates

Faculty, Staff and Student Publications

Lynch syndrome (LS), caused by inherited mutations in DNA mismatch repair genes, including MSH2, carries a 60% lifetime risk of developing endometrial cancer (EC). Beyond hypermutability, mechanisms driving LS-associated EC (LS-EC) remain unclear. We investigated MSH2 loss in EC pathogenesis using a mouse model (PR-Cre Msh2LoxP/LoxP, abbreviated Msh2KO), primary cell lines, human tissues, and human EC cells with isogenic MSH2 knockdown. By 8 months, 58% of Msh2KO mice developed endometrial atypical hyperplasia (AH), a precancerous lesion. At 12-16 months, 50% of Msh2KO mice exhibited either AH or ECs with histologic similarities to human LS-ECs. Transcriptomic profiling of EC from Msh2KO …

Rice Cultivar Tolerance To Preemergence- And Postemergence-Applied Fluridone, Maria Carolina Souza, Jason K. Norsworthy, Pamela Carvalho-Moore, Amar J. Godar, Samuel B. Fernandes, Thomas R. Butts

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Fluridone was registered for use in rice production in 2023, offering a new herbicide site of action for growers. However, little information is available on the degree of rice tolerance to this herbicide. Field experiments conducted in 2022 and replicated in 2023 near Colt, AR, evaluated the tolerance of 12 rice cultivars to fluridone, applied preemergence or at the 3-leaf growth stage, in separate experiments. Each experiment consisted of one cultivar. Fluridone rates included 0, 168 (1 x label rate), and 336 (2 x label rate) g ai ha-1 in all experiments. Visible injury varied between years in all experiments, …

Crème De La Conference: 8th World Congress Of Pediatric Cardiology And Cardiac Surgery-Wcpccs 2023, Carissa M. Baker-Smith, Liesl Zühlke, Jennifer Co-Vu, Shubhika Srivastava, Renelle George, Shelby Kutty, Ali N. Zaidi, David J. Goldberg, Erica D. Sood, Kathryn M. Dodds, David S. Cooper, Mitchel I. Cohen, Gil Wernovsky, Jeffrey P. Jacobs

Department of Medicine Faculty Papers

No abstract provided.

Unveiling The Genetic Landscape Of Coronary Artery Disease Through Common And Rare Structural Variants, Kruthika R Iyer, Shoa L Clarke, Rodrigo Guarischi-Sousa, Ketrin Gjoni, Adam S Heath, Erica P Young, Nathan O Stitziel, Cecelia Laurie, Jai G Broome, Alyna T Khan, Joshua P Lewis, Huichun Xu, May E Montasser, Kellan E Ashley, Natalie R Hasbani, Eric Boerwinkle, Alanna C Morrison, Nathalie Chami, Ron Do, Ghislain Rocheleau, Donald M Lloyd-Jones, Rozenn N Lemaitre, Joshua C Bis, James S Floyd, Gregory L Kinney, Donald W Bowden, Nicholette D Palmer, Emelia J Benjamin, Matthew Nayor, Lisa R Yanek, Brian G Kral, Lewis C Becker, Sharon L R Kardia, Jennifer A Smith, Lawrence F Bielak, Arnita F Norwood, Yuan-I Min, April P Carson, Wendy S Post, Stephen S Rich, David Herrington, Xiuqing Guo, Kent D Taylor, Joann E Manson, Nora Franceschini, Katherine S Pollard, Braxton D Mitchell, Ruth J F Loos, Myriam Fornage, Lifang Hou, Bruce M Psaty, Kendra A Young, Elizabeth A Regan, Barry I Freedman, Ramachandran S Vasan, Daniel Levy, Rasika A Mathias, Patricia A Peyser, Laura M Raffield, Charles Kooperberg, Alex P Reiner, Jerome I Rotter, Goo Jun, Paul S De Vries, Themistocles L Assimes

Faculty, Staff and Student Publications

Background: Genome-wide association studies have identified several hundred susceptibility single nucleotide variants for coronary artery disease (CAD). Despite single nucleotide variant-based genome-wide association studies improving our understanding of the genetics of CAD, the contribution of structural variants (SVs) to the risk of CAD remains largely unclear.

Method and results: We leveraged SVs detected from high-coverage whole genome sequencing data in a diverse group of participants from the National Heart Lung and Blood Institute's Trans-Omics for Precision Medicine program. Single variant tests were performed on 58 706 SVs in a study sample of 11 556 CAD cases and 42 907 controls. …

The Potential Of Using Screening Tools For Bipolar Disorder To Predict Lithium Response, Delfina Janiri, Mario Pinto, Silvia Montanari, Ester Maria Marzo, Greta Sfratta, Guglielmo Donofrio, Alexia Koukopoulos, Giovanni Camardese, Alessio Simonetti, Lorenzo Moccia, Gianna Autullo, Gabriele Sani

Faculty, Staff and Students Publications

Background/Objectives: Lithium is the gold standard for treating Bipolar Disorder (BD), but its effectiveness varies widely. While clinical and environmental factors may influence response, it remains unclear if screening tools can reliably predict lithium response outcomes. This study explores this potential using two widely used screening instruments for BD.

Methods: A total of 146 patients with BD were evaluated. Lithium response was assessed using the Alda Scale, while hypomanic and manic symptoms were characterized through the Hypomania Checklist-32 (HCL-32) and the Mood Disorder Questionnaire (MDQ). Group differences in HCL-32 and MDQ scores were analyzed using ANOVA, and a multivariate model …

Machine Learning-Enhanced Surface-Enhanced Spectroscopic Detection Of Polycyclic Aromatic Hydrocarbons In The Human Placenta, Oara Neumann, Yilong Ju, Andres B Sanchez-Alvarado, Guodong Zhou, Weiwu Jiang, Bhagavatula Moorthy, Melissa A Suter, Ankit Patel, Peter Nordlander, Naomi J Halas

Faculty, Staff and Students Publications

The detection and identification of polycyclic aromatic hydrocarbons (PAHs) and their derivatives, polycyclic aromatic compounds (PACs), are essential for environmental and health monitoring, for assessing toxicological exposure and their associated health risks. PAHs/PACs are the most dangerous chemicals found in tobacco smoke, and cigarette use during pregnancy can convey these molecules to the developing fetus through the placenta. This exposure is associated with many negative health outcomes, from premature birth to sudden infant death syndrome and adverse neurodevelopmental disorders. This study demonstrates the use of surface-enhanced Raman and surface-enhanced infrared absorption spectroscopies for direct detection of PAHs/PACs in human placental …

Metabolic Effects Of Testosterone Added To Intensive Lifestyle Intervention In Older Men With Obesity And Hypogonadism, Adrian M Gonzalez-Gil, Yoann Barnouin, Alessandra Celli, Viola Viola, Marcos D Villarreal, Maria Liza Duremdes Nava, Adam Sciuk, Clifford Qualls, Reina Armamento-Villareal, Dennis T Villareal

Faculty, Staff and Students Publications

Background: Whether testosterone replacement therapy (TRT) conveys additional cardiometabolic benefit to an intensive lifestyle therapy (LT) in older men with obesity and hypogonadism remains unclear.

Objective: To determine whether TRT augments the effect of LT on metabolic outcomes in older men with obesity and hypogonadism.

Design: Secondary analysis of a randomized, double-blind, placebo-controlled trial.

Setting: Veterans Affairs Medical Center.

Participants: Eighty-three older (age ≥ 65 years) men with obesity (body mass index ≥ 30 kg/m2) and persistently low Am testosterone (< 10.4 nmol/L) associated with frailty.

Interventions: LT (weight management and exercise training) plus either testosterone (LT + TRT) or placebo (LT + Pbo) for …

Unveiling The Genetic Landscape Of Coronary Artery Disease Through Common And Rare Structural Variants, Kruthika R Iyer, Erica P Young, Nathan O Stitziel, Et Al.

2020-Current year OA Pubs

BACKGROUND: Genome-wide association studies have identified several hundred susceptibility single nucleotide variants for coronary artery disease (CAD). Despite single nucleotide variant-based genome-wide association studies improving our understanding of the genetics of CAD, the contribution of structural variants (SVs) to the risk of CAD remains largely unclear.

METHOD AND RESULTS: We leveraged SVs detected from high-coverage whole genome sequencing data in a diverse group of participants from the National Heart Lung and Blood Institute's Trans-Omics for Precision Medicine program. Single variant tests were performed on 58 706 SVs in a study sample of 11 556 CAD cases and 42 907 controls. …

Late Holocene Coastal And Estuarine Environments Of The Shanghai Area, People's Republic Of China, Li Jinan, Yan Qinshang

The Geographical Bulletin

Four major sedimentary environments have been identified in the Shanghai area which were deposited over the past 7,000 years, 3 to 20 meters above a Pleistocene basal clay. These are marsh, lagoon, recurved spit and tidal flat. The morphology west of Shanghai is a fresh water marsh since it was not transgressed by rising Holocene sea levels. In the central area, a recurved spit and lagoon had developed from 6,500 years B.P. to 3,500 years B.P. However, the tidal flat has characterized coastal sedimentation in the eastern part of Shanghai since 3,000 years B.P.

Tracking The Effects Of Time Zone Shift On An Individual’S Circadian Rhythm, Amaka Eziakonwa, Erich Stahmer, Amega Nguyen, Samuel Park, Madison Payne, Alexis Salinas, Deborah Bell-Pedersen, Julie A. Zacharias-Simpson

Annual Research Symposium

This poster presentation aims to understand how a rapid time-zone change can affect an individual’s circadian rhythms. By quantifying changes in physiological rhythms, the study seeks to develop targeted therapeutic interventions to mitigate the negative effects of jetlag.