Digital Commons Network^™

Optimization Of Extraction Process Of Polysaccharides From Mulberry Leaves And Determination Of The Antioxidant Activity In Vitro, Wu Jun, Yang Biwen, Zhao Pei, Ma Jingqiu, Wang Xiaojing, Huang Yue

Food and Machinery

［Objective］ This study aimed to optimize the extraction process of polysaccharides from mulberry leaves using deep eutectic slovents (DES ) and assess their antioxidant properties.［Methods］ Autumn mulberry leaf powder was used as the raw material,and ultrasonic -assisted extraction with complex enzymes facilitated the process.The composition of DES and the extraction conditions were optimized using Box -Behnken response surface methodology,with polysaccharide yield as the primary indicator.Antioxidant activity was evaluated by measuring the scavenging abilities of against DPPH radicals,ABTS+ radicals,and hydroxyl radicals.［Results］］ The optimal extraction conditions were as follows:a choline chloride/malic acid molar ratio of 1∶4,water content 44%,liquid -solid ratio of 40∶1 …

Review Of The Active Function Of Birch Juice And Its Product Development, Xu Lingfei, Zhang Guofeng, Wang Weiwei, Zhang Wenjun

Food and Machinery

Birch juice is a natural beverage with numerous health benefits including providing essential vitamins and minerals,treating kidney disease,relieving gout,exhibiting antibacterial and anti -inflammatory properties,and enhancing immunity.As a rising focus in the food industry,birch juice has potential commercial value,but there are few systematic reviews on birch juice and its products.In order to promote the sustainable development of the birch juice industry in China,based on the main components,efficacy and application of the birch juice,this review summarized the current situation of the birch juice product development and the problems faced by the birch juice industry,and prospected the future development of the birch juice …

Special Characteristics Of Airline Food And Quality Control During Processing , Transportation , And Storage, Zhang Qian, Yuan Yuan, Tao Yuan, Yan Bowen

Food and Machinery

To comprehensively improve the whole -process efficiency and quality of airline food,this paper introduced the special characteristics of airline food regarding the nutrition,safety,and flavor under high altitude conditions,especially the changes in passengers' perception of food.The novel technologies and initiatives for quality control throughout the entire supply chain,from processing to cold chain logistics and to the supervision of finished products were described systematically.Furthermore,the development trends of the airline food industry were discussed,including raw material traceability,intelligent production modes,functional packaging innovation,and development of reheating technology.

Research Progress And Industry Status Of Novel Processing Technology Of Nutritious Rice Products, Ding Jian, Li Yupeng, Qian Mingji, Jin Zhengyu, Lin Qinlu, Cui Bo, Lai Xiarong, Wai Jinfu, Fang Yong

Food and Machinery

With the enhanced national health awareness,there is an increasing consumers ’ demand for healthy food,and more attentions are drawn to nutritious rice products.Therefore,the development of novel nutritious rice products is of great significance for diversifying the nutritional staple rice foods,improving glucose metabolism,avoiding chronic diseases,and promoting a healthier diet.The latest physical and biological processing technologies in improving the nutritional function of rice products are reviewed.The current status of the nutritious rice products industry is summarized and prospect is outlined for industrial development based on market demands.

Impact Of Voluntary Exercise On Systemic Inflammation In A 2? Hit Model Of Heart Failure With Preserved Ejection Fraction, Heather Quiriarte, Eunhan Cho, Youyoung Kim, Jake E. Doiron, Gregory Davis, James Stampley, Robert C. Noland, Zhen Li, Sanjiv J. Shah, Brian A. Irving, Guillaume Spielmann, David J. Lefer, Timothy D. Allerton

Faculty Publications

No abstract provided.

Minutes, Curriculum Committee Meeting, Tuesday, February 18, 2025, Curriculum Committee

Curriculum Committee Minutes

No abstract provided.

Experiences Of Former Foster Youths With Learning Disabilities Who Transitioned Into Adulthood, Phyllis J. Phillips

Walden Dissertations and Doctoral Studies

Foster youths with learning disabilities face numerous challenges as they transition out of care, including housing instability, unemployment, and mental health issues. Despite these barriers, research focusing on this specific population is limited. Guided by Taormina’s adult personal resilience theory, this qualitative case study explored the experiences and perceptions of former foster youths with learning disabilities to inform interventions and improve service delivery and policy improvements. The research questions addressed the experiences of former foster youths with learning disabilities transitioning out of care, the unique challenges associated with transitioning out of foster care as experienced by former foster youths with …

Systems And Methods For Determining Cell Number Count In Automated Stereology Z-Stack Images, Palak Pankajbhai Dave, Dmitry Goldgof, Lawrence O. Hall, Peter R. Mouton

USF Patents

Systems and methods for automated stereology using deep learning are disclosed. The systems include an update in the form of a semi-automatic approach for ground truth preparation in 3D stacks of microscopy images (disector stacks) for generating more training data. The systems also present an exemplary disector-based MIMO framework where all the planes of a 3D disector stack are analyzed as opposed to a single focus-stacked image (EDF image) per stack. The MIMO approach avoids the costly computations of 3D deep learning-based methods by using the 3D context of cells in disector stacks; and prevents stereological bias in the previous …

Deep5mc: Predicting 5-Methylcytosine (5mc) Methylation Status Using A Deep Learning Transformer Approach, Evan Kinnear, Houssemeddine Derbel, Zhongming Zhao, Qian Liu

Faculty, Staff and Student Publications

DNA methylations, such as 5-methylcytosine (5mC), are crucial in biological processes, and aberrant methylations are strongly linked to various human diseases. Genomic 5mC is not randomly distributed but exhibits a strong association with genomic sequences. Thus, various computational methods were developed to predict 5mC status based on DNA sequences. These methods generated promising achievements and overcome the limitations of experimental approaches. However, few studies have comprehensively investigated the dependency of 5mC on genomic sequences, and most existing methods focus on specific genomic regions. In this work, we introduce Deep5mC, a deep learning transformer-based method designed to predict 5mC methylations. Deep5mC …

Paradigm Shift In Obesity Treatment: An Extensive Review Of Current Pipeline Agents, Ecesu Çeti̇n, Brian Pedersen, Mehmet Furkan Burak

Turkish Journal of Medical Sciences

Obesity is a multifaceted disease that poses a significant public health challenge. Recent discoveries in understanding the biological pathways that regulate satiety and metabolism have led to a shift in the treatment paradigm for obesity. Thus, the gap between pharmacological and surgical interventions has diminished. The latest approved anti-obesity medications are achieving weight loss comparable to surgery. These GLP-1 analog-based therapies not only cause substantial weight loss but also improve obesity-associated comorbidities. However, there are still unmet needs in obesity care, and treatment options with alternative pathways are necessary. Whether achieved through lifestyle changes or medication, weight loss often leads …

Synthetic Osteobiologics In Spine Surgery: A Review, Aydin Si̇nan Apaydin, Eli Johnson, Prince Antwi, Brett Rocos, Michael M. Haglund, Christopher Shaffrey, Peter Passias, Muhammad Adb-El-Barr, Khoi Than

Turkish Journal of Medical Sciences

Background/aimOsteobiologics are increasingly used in orthopedics and spine surgery to facilitate bone healing and prevent non-union. Synthetic osteobiologics are artificial materials crafted in laboratories that aim to replicate the natural composition and functionality of bone. Notable examples, such as calcium phosphate and calcium sulfate, are engineered to mirror the mineral aspect of bone. They mimic human bone functionality, exhibiting osteoconductive, osteoinductive, and osteogenic properties. These characteristics promote cell attachment, migration, recruitment, and differentiation. Consequently, synthetic osteobiologics (osteoconductive grafts) have been introduced in bone fracture repair. The main strength of synthetic osteobiologics in spine surgery lies in improving fusion rates and …

Genetic Mutations And Prognostic Indicators In Differentiated Thyroid Cancer: A Molecular Perspective, Hali̇m Özçevi̇k, Müge Öner Tamam, Gündüzalp Buğrahan Babacan, Selma Şengi̇z Erhan, Merve Nur Acar Tayyar, Bi̇ray Ertürk

Turkish Journal of Medical Sciences

Background/aim: This study aimed to investigate the relationship between the presence of BRAF, HRAS, NRAS, and KRAS gene mutations and the development of dedifferentiation (iodine-refractory disease) and extrathyroidal disease in patients with differentiated thyroid carcinoma (DTC).Materials and methods: Seventy-seven adult patients classified as intermediate and high-risk according to the ATA 2015 guidelines, who underwent total thyroidectomy followed by radioiodine I-131(RAI) therapy between June 2014 and December 2022, were included. Clinical data were collected via the hospital information system, including the number of surgeries, RAI treatments, and levels of thyroglobulin(Tg), anti-thyroglobulin, and thyroid-stimulating hormone. Histopathological subtypes of DTC were re-evaluated, and …

Impact Of Concurrent Parathyroid Adenoma On The Recurrence Of Differentiated Thyroid Carcinoma: A Retrospective Study, Derya Çayir, Alev Çinar, Mehmet Bozkurt, Bahadir Külah

Turkish Journal of Medical Sciences

Background/aim: The impact of concurrent parathyroid adenoma in differentiated thyroid carcinoma remains unclear. This study was performed to compare the recurrence rates of patients operated on for differentiated thyroid carcinoma with concomitant parathyroid adenoma and those operated on for thyroid carcinoma without detected parathyroid adenoma.Materials and methods: This retrospective study examined 340 patients who underwent total thyroidectomy for thyroid carcinoma at our institution. We compared the patients with concurrent parathyroid adenoma to those without, assessing clinical, laboratory, surgical, and histopathological findings and thyroid carcinoma recurrence over a 6-year postoperative period.Results: Among all patients, 53/340 (16%) were identified with parathyroid adenoma, …

Evaluation Of Nonmotor Symptoms In Myasthenia Gravis Patients, Aysel Tekeşi̇n, Çağla Şi̇şman, Ufuk Emre Toprak, Alena Sar, Burcu Akalin, Goncagül Koşargeli̇r, Meli̇h Tütüncü, Enes Yi̇ği̇t

Turkish Journal of Medical Sciences

Background/aim: Myasthenia gravis (MG) is chronic autoimmune disorder characterized primarily by muscle weakness and fatigue, due to autoantibodies targeting acetylcholine receptor at neuromuscular junction. In this study, we aimed to evaluate non-motor symptoms in myasthenia gravis patients and compare them with disease duration, severity and clinical features.Materials and methods: This prospective study was conducted with thirty-five myasthenia gravis patients and thirty-five healthy volunteers. Total of 35 patients, 17 women and 18 men with mean age of 52.9±13.6 years constituted patient group. Control group consisted of total of 35 participants, 23 women and 12 men with mean age of 46.9±12.2 years. …

Integrated Convolutional Neural Network For Skin Cancer Classification With Hair And Noise Restoration, Ni̇dhi̇ Bansal, Sri̇dhar Sundaramurthy

Turkish Journal of Medical Sciences

Background/aim: Skin lesions are commonly diagnosed and classified using dermoscopic images. There are many artifacts visible in dermoscopic images, including hair strands, noise, bubbles, blood vessels, poor illumination, and moles. These artifacts can obscure crucial information about lesions, which limits the ability to diagnose lesions automatically. This study investigated how hair and noise artifacts in lesion images affect classifier performance and how they can be removed to improve diagnostic accuracy.Materials and methods: A synthetic dataset created using hair simulation and noise simulation was used in conjunction with the HAM10000 benchmark dataset. Moreover, integrated convolutional neural networks (CNNs) were proposed for …

Relationship Between Bleeding Risk And Arterial Stiffness In Patients With Cerebral Aneurysms, Mehmet Seli̇m Gel, Hasan Çağri Postuk, İskender Samet Daltaban, Savaş Özer, Ercan Aydin, Emrah Keski̇n

Turkish Journal of Medical Sciences

Background/aimA risk factor assessment evaluating the susceptibility of cerebral aneurysms (CA) to rupture has not yet been established. Therefore, the clinical management of unruptured CA remains uncertain. Our aim was to assess whether arterial stiffness is associated with the development of rupture in patients with cerebral aneurysms.Materials and methodsAfter magnetic resonance angiography, 49 patients with cerebral aneurysm and subarachnoid haemorrhage and ruptured cerebral aneurysm detected by digital substraction angiography were included in the study. Arterial stiffness was measured using the VaSera VS-1000 vascular scanning system, expressed as cardio-ankle brachial index (CAVI). CAVI values were compared between patient groups.ResultsThe mean age …

Relationship Between The Density Of Degenerated Neurons In The Carotid Body And Changes In Blood Ph, Hakan Kina, Aydin Si̇nan Apaydin

Turkish Journal of Medical Sciences

Background/aimCarotid artery is the majority artery for brain feeding. Carotid Bodies (CBs) are located in carotid bifurcation and regulate body fluid pH. We aimed to evaluate the changes in CB-related pH levels as a consequence of degeneration induced by the ligation of both Common Carotid Arteries (BCCAL).Materials and methodsWe included 23 adult male New Zealand rabbits. A control group (n= 5); a sham group (0.5 mL saline injected n=5) and the main study group (subjected to the BCCAL procedure, n = 13). We monitored and recorded pH levels, and cardiac rhythms before, during, and after the experiments at two-day intervals. …

Relationship Between Hand Osteoarthritis Severity And Serum Resistin Levels In Women With Metabolic Syndrome: A Case-Control Study, Eki̇n Başak Doğanci, Berna İmge Aydoğan, Ni̇lgün Başkal, Safi̇ye Tuncer

Turkish Journal of Medical Sciences

Background/aimWe aimed to determine the relationship between clinical and radiological severity of hand osteoarthritis and serum resistin levels in women diagnosed with metabolic syndrome.Materials and methodsThe study was designed as a case-control study. A total of 87 women aged 50-65 years were evaluated; 29 patients diagnosed with metabolic syndrome and hand osteoarthritis (MetS (+), hand OA (+); Group 1), 29 patients without metabolic syndrome but with hand osteoarthritis (MetS (-), hand OA (+); Group 2) and 29 healthy controls (MetS (-), hand OA (-); Group 3). The diagnostic criteria of American College of Rheumatology (ACR) for hand osteoarthritis and National …

In Vitro Anticancer, Antioxidant And Chelating Activities Of Natural Organosulfur Compounds Originated From Türkiye: An Investigation On Breast And Colorectal Cancer Cells, Ümmügülsüm Polat Korkunç, Hi̇lal Çalik, Leyla Polat Köse, Rabi̇a Çakir Koç, Emi̇ne Karakuş

Turkish Journal of Medical Sciences

Background/aim:Taşköprü garlic, cultivated in the Taşköprü region of Kastamonu province, is a very famous in Türkiye.This study aimed to determine the anticancer and antioxidant effects of extracts from Kastamonu Taşköprü garlic on human breast cancer and colorectal cancer cells.Materials and methods:Taşköprü garlic, which contains natural organosulfur compounds, has a geographical registration. Taşköprü garlic, which contains natural organosulfur compounds (OSCs), has a geographical registration.Garlic contains oil- and water-soluble OSCs known to exhibit anticancer activity by interfering with MCF-7 and Caco-2 proliferation and tumor metastasis. In this study, the antiproliferative activity of oil- and water-soluble garlic extracts with and without glutathione at …

Are Cinnamon Derivatives Effective And Safe For Diabetes?, Methi̇ye Mancak, Ufuk Koca Çalişkan

Turkish Journal of Medical Sciences

Background/aimCinnamon spice is obtained by drying the tree bark of the Cinnamomum Schaeff genus. Cinnamomum genus belongs to the Lauraceae family and there are approximately 250 different species around the world. The most common species in the market are Cinnamomum verum J. S. Presl, C. cassia (L.) J. Presl, C. burmannii (Nees & T. Nees) Blume and C. loureiroi Nees. Cinnamon and its by-products are used for many years for their antidiabetic effect. In this research, the major chemical content and in vitro antidiabetic activities of different commercially available cinnamon samples were evaluated to conclude whether they are safe to …

Association Of Certain Biochemical Parameters Related To Bone Cycle With Genotype In Mps Iii-B Patients, Seda Gökkurt, İrem Peker Eyüboğlu, Banu Nur Güzel, Ercan Mihçi, Ayşe Özer, Mustafa Akki̇pri̇k

Turkish Journal of Medical Sciences

Background/aim: The aim of this study is to investigate the genotype-phenotype correlation in Sanfilippo type B patients in terms of bone formation/resorption parameters, and to determine the release/inhibition of biomarkers accompanying osteoporosis.Materials and Methods: Plasma levels of Osteoprotegerin, Matrix metalloproteinases (MMP2, MMP9), TIMP-1, TIMP-2, BALP, Cathepsin K, and TRACP-5b were examined by ELISA method in MPS IIIB patients. At the same time, mutations in the NAGLU gene causing this disease were detected by whole exome sequencing, and their correlation with biochemical parameters was investigated.Results: Based on the enzyme analysis results, MMP-9, TIMP1, TIMP-2, and MMP-2 were significantly high, while Cathepsin-K …

Ascorbic Acid Exhibits More Of A Protective Effect Than Estradiol Against Nephrotoxicity Induced By Malathion In Rats: A Histopathological And Molecular Docking Study, Mohammad Alhilal, Mahmoud Salem, Ahmed Albakoush, Suzan Alhilal, Basant Farag, Sobhi M. Gomha

Turkish Journal of Medical Sciences

Background/Aim: Despite the known harmful effects associated with malathion toxicity in various organs, it continues to be widely used for plant protection and insect control. This study is the first to compare the protective effects of estradiol and ascorbic acid against malathion-induced nephrotoxicity through histopathological assessment and molecular docking analyses.

Materials and Methods: This study was conducted using 20 female albino rats that were distributed into sham, malathion, malathion + estradiol, and malathion + ascorbic acid groups. Nephrotoxicity was induced by daily treatment with malathion, and the effects of estradiol and ascorbic acid on nephrotoxicity were evaluated. After 4 weeks …

Identification And Co-Regulation Of Main Residual Bacteria In Ready-To-Eat Duck Esophagus, Zheng Ruisheng, Yuan Sihui, Huang Yilin, Li Jiani, Han Shuxian, Su Kunlun

Food and Machinery

［Objective ］ This study aimed to analyze the main residual bacteria and control the bacterial growth effectively.［Methods ］ The 16S rDNA technology was used to identify the main residual bacteria.The compound antibacterial experiments were carried out to kill the heat-resistance residual bacteria which were screened by high temperature test.［Results ］ A total of 47 strains of genera belonging to 8 strains of genera were isolated from 5 groups of samples,including raw and auxiliary materials,final RDEs products spoilaged samples etc.The 8 strains of genera were Bacillus,Streptococcus,Moraxella,Alkalihalobacillus,Kurthia,Lactococcus,Enterococcus and Vagococcus respectively.It was found the RDEs easily caused secondary pollution after mixing the sauce …

Predicting Diabetes Self-Management Education Engagement: Machine Learning Algorithms And Models, Xiangxiang Jiang, Gang Lv, Minghui Li, Jing Yuan, Z Kevin Lu

Faculty Publications

Introduction Diabetes self-management education (DSME) is endorsed by the American Diabetes Association (ADA) as an essential component of diabetes management. However, the utilization of DSME remains limited in the USA. This study aimed to investigate current DSME participation among the older population and to identify comprehensive factors of DSME engagement through employing various machine learning (ML) models based on a US nationally representative survey linked to claims data.

Research design and methods Data from the Medicare Current Beneficiary Survey were employed, and this study included data on US Medicare beneficiaries with diabetes from 2017 to 2019. Comprehensive variables following the …

The Effect Of Processing Mode On The Characteristics Of Crystalline Sorbitol Powder, Yu Shankai, Yan Yongqiu, Yu Xindi, Sun Yi, Tao Gang, Jia Fuhuai

Food and Machinery

［Objective ］ This study aimed to improve the fluidity of sorbitol to be used as a raw material for direct tablet pressing.［Methods ］ XTAB 290 crystalline sorbitol was sieved,and particles smaller than 50 mesh were further processed by fluidized bed granulation or wet granulation.The particle size distribution and fluidity of sorbitol were determined using a laser particle size analyzer and an intelligent micromeritics properties tester，respectively.［Results］ The results showed that the flowability of the particles treated by all methods was good enough to meet the requirements for direct compression.Specifically,the sieving treatment significantly improved the flowability index of sorbitol particles with a …

Determination Of Protein Peptide Content In Edible Jiaosu, Liu Zeya, Zhao Ran, Li Minxia, Zhang Hongchen, Kang Xiaojing, Dai Jun

Food and Machinery

［Objective ］ This study aimed to establish a method to determine the content of peptides in edible Jiaosu accurately.[Methods ] After the sample was precipitated with a certain concentration of trichloroacetic acid (TCA ) to remove protein macromolecules,the total hydrolyzed amino acid content and free amino acid content in the sample were determined by amino acid analyzer according to the two national standards GB 5009.124—2016 and GB/T 30987 —2020 respectively.The peptide content is calculated by the difference between the two.For samples containing collagen protein in raw materials,refer to the first method of GB/T 30987,that is,the sulfonic acid type cation exchange …

The Effect Of Brown Rice Flour Particle Size On The Quality Of Brown Rice Noodles, Xiong Shaobai, Yang Xiaoli, Chen Tingting, Luo Shunjing, Liu Chengmei

Food and Machinery

［［Objective ］］ This study aimed to investigate the effect of brown rice particle size on the quality of brown rice noodles. ［［Methods ］］ Brown rice flours with average particle sizes (D[4,3]) of 370,86,62,47,and 30 μm were prepared using low -temperature impact milling.Noodles were made from each flour,and their starch short -range ordered structure,crystalline structure,cooking quality,and texture properties were analyzed. ［［Results ］］ Both the short -range order and relative crystallinity of starch in brown rice noodles first increased and then decreased with decreasing particle size.Hardness and chewiness also followed this trend.Noodles prepared from flour with a moderate particle size (D[4,3] of …

Analysis Of Key Volatile Flavor Substances In Boiled Spicy Pork Slices During Different Cooking And Processing Stages, Yang Qian, Jia Hongfeng, Zhang Miao, Huang Jia

Food and Machinery

［Objective ］ The purpose of this study is to improve the quality of boiled spicy pork slices and promote standardized and industrialized production.［Methods ］ The changes of volatile flavor substances in boiled spicy pork slices were analyzed by gas chromatography-mass spectrometry (GC-MS ).The contents of the main volatile flavor substances were calculated by adding internal standard substances,and the odor activity value (OAV ) was used to determine the key volatile flavor substances in samples.［Results］ 136 volatile flavor substances were identified in samples.The number of volatile flavor substances in samples during slicing,curing,boiling,and pouring oil was 57,66,57 and 63 respectively.Ketones ’ contents …

Effects Of Glycosylation Combined With Tannic Acid Modification On The Emulsification Properties Of Molten Globule Egg White Protein, Wan Jun, Zhang Xiaoqin, Deng Bowen, Ai Minmin, Xie Zhequan

Food and Machinery

［Objective］ This study aimed to develop a modification method to stabilize emulsions using molten -globule state egg white protein (MGEWP ).［Methods］ MGEWP was prepared through partial denaturation of egg white protein via pH induction.The synergistic effects of D-xylose and tannic acid on the emulsifying properties of MGEWP were analyzed.［Results］］ Increasing tannic acid concentration significantly elevated the turbidity and browning degree of D-xylose glycosylated MGEWP (X-MGEWP ) (P<0.05).Tannic acid facilitated the unfolding of X -MGEWP,exposing free sulfhydryl and active groups,which enhanced molecular flexibility,apparent viscosity,storage modulus and loss modulus (P<0.05).However,under extreme pH value treatment,the active groups of MGEWP were passivated,inhibiting the Maillard reaction with D-xylose.As a result,there was no significant difference in emulsification properties between glycosylated X -MGEWP and untreated MGEWP (P>0.05).The addition of tannic acid enhanced the emulsifying activity of X -MGEWP obviously (P<0.05),and it was dose -dependent with tannic acid concentration.［Conclusion］ The synergistic modification of MGEWP with D-xylose/tannic acid represents a promising method for enhancing the emulsifying properties of MGEWP,offering potential applications in emulsion stabilization.

Allostatic Load And Incident Dementia Among Older Adults In The United States, Mohammed Usman Kabeto

Walden Dissertations and Doctoral Studies

Allostatic load (AL), the cumulative physiological burden of chronic stress, is a significant health problem, and it has been associated with adverse health outcomes, including cognitive functioning. There is a paucity of literature examining associations between AL and incident dementia in the United States. This quantitative study used data from the United States Health and Retirement Study cohort (2016-2020) to examine the association between AL quartile and incident dementia among participants who were aged 56 and older at baseline. Dementia status was determined measuring immediate and delayed recall, serial seven subtraction, and backward count, as well as self-report conditions for …