Digital Commons Network^™

Clostridioides Difficile Colonization Is Not Mediated By Bile Salts And Utilizes Stickland Fermentation Of Proline In An In Vitro Model, Xiaoyun Huang, April E Johnson, Joshua N Brehm, Thi Van Thanh Do, Thomas A Auchtung, Hugh C Mccullough, Armando I Lerma, Sigmund J Haidacher, Kathleen M Hoch, Thomas D Horvath, Joseph A Sorg, Anthony M Haag, Jennifer M Auchtung

Faculty, Staff and Students Publications

Treatment with antibiotics is a major risk factor for Clostridioides difficile infection, likely due to depletion of the gastrointestinal microbiota. Two microbiota-mediated mechanisms thought to limit C. difficile colonization include the conversion of conjugated primary bile salts into secondary bile salts toxic to C. difficile growth and competition between the microbiota and C. difficile for limiting nutrients. Using a continuous flow model that simulates the nutrient conditions of the distal colon, we investigated how treatment with 6 clinically used antibiotics influenced susceptibility to C. difficile infection in 12 different microbial communities cultivated from healthy individuals. Antibiotic treatment reduced microbial richness; …

Water Hammer Phenomenon In Coronary Arteries: Scientific Basis For Diagnostic And Predictive Modeling With Acoustic Action Mapping, Khiem D. Ngo, Thach Nguyen, Huan Dat Pham, Hadrian Tran, Dat Q. Ha, Truong S. Dinh, Imran Mihas, Mihas Kodenchery, C. Michael Gibson, Hien Q. Nguyen

School of Medicine Publications

Background: In the study of coronary artery disease, the mechanisms underlying atherosclerosis initiation and progression or regression remain incompletely understood. Our research conceptualized the cardiovascular system as an integrated network of pumps and pipes, advocating for a paradigm shift from static imaging of coronary stenosis to dynamic assessments of coronary flow. Further review of fluid mechanics highlighted the water hammer phenomenon as a compelling analog for processes in coronary arteries. Methods: In this review, the analytical methodology employed a comprehensive, multifaceted approach that incorporated a review of fluid mechanics principles, in vitro acoustic experimentation, frame-by-frame visual angiographic assessments of in …

Monitoring And Modeling Legacy Tree Response To Restoration Treatments In The Klamath Mountains, Oregon, Usa, Isaac Joseph Ball

Dissertations and Theses

Climate change and its disruption of historical drought and wildfire patterns pose a substantial threat to forest health in the western United States. This threat is compounded by past management practices like fire suppression. The largest, oldest, and most ecologically valuable trees are particularly vulnerable, making their conservation a key objective of climate-adaptive forest management. Restoration treatments such as mechanical thinning have been shown to enhance tree growth and drought resilience in dry conifer forests, but long-term monitoring is necessary to understand their sustained effects. This study used dendroecological tree-ring analysis to investigate the effects of thinning on the growth, …

2′-Fucosyllactose Inhibits Human Norovirus Replication In Human Intestinal Enteroids, Ketki Patil, B Vijayalakshmi Ayyar, Nicole M Hayes, Frederick H Neill, Lars Bode, Mary K Estes, Robert L Atmar, Sasirekha Ramani

Faculty, Staff and Students Publications

Human noroviruses (HuNoVs) are the leading cause of acute gastroenteritis worldwide. Currently, there are no targeted antivirals for the treatment of HuNoV infection. Histo-blood group antigens (HBGAs) on the intestinal epithelium are cellular attachment factors for HuNoVs; molecules that block the binding of HuNoVs to HBGAs thus have the potential to be developed as antivirals. Human milk oligosaccharides (HMOs) are glycans in human milk with structures analogous to HBGAs. HMOs have been shown to act as decoy receptors to prevent the attachment of multiple enteric pathogens to host cells. Previous X-ray crystallography studies have demonstrated the binding of HMO 2′-fucosyllactose …

From Religion To Cult: Terministic Screens, Alexis Brooke Underwood

Honors Capstone Projects and Theses

No abstract provided.

Pskh1 Kinase Activity Is Differentially Modulated Via Allosteric Binding Of Ca2+ Sensor Proteins, Christopher R Horne, Toby A Dite, Samuel N Young, Lucy J Mather, Laura F Dagley, Jared L Johnson, Tomer M Yaron-Barir, Emily M Huntsman, Leonard A Daly, Dominic P Byrne, Antonia L Cadell, Boaz H Ng, Jumana Yousef, Dylan H Multari, Lianju Shen, Luke M Mcaloon, Gerard Manning, Mark A Febbraio, Anthony R Means, Lewis C Cantley, Maria C Tanzer, David R Croucher, Claire E Eyers, Patrick A Eyers, John W Scott, James M Murphy

Children’s Nutrition Research Center Staff Publications

Protein Serine Kinase H1 (PSKH1) was recently identified as a crucial factor in kidney development and is overexpressed in prostate, lung, and kidney cancers. However, little is known about PSKH1 regulatory mechanisms, leading to its classification as a “dark” kinase. Here, we used biochemistry and mass spectrometry to define PSKH1’s consensus substrate motif, protein interactors, and how interactors, including Ca2+ sensor proteins, promote or suppress activity. Intriguingly, despite the absence of a canonical Calmodulin binding motif, Ca2+-Calmodulin activated PSKH1 while, in contrast, the ER-resident Ca2+ sensor of the Cab45, Reticulocalbin, Erc55, Calumenin (CREC) family, Reticulocalbin-3, suppressed PSKH1 catalytic activity. In …

A Geologist, A Photographer And A Theologian Walk Into The Woods: Wonder, Grief And Hope In An Old-Growth Forest In An Age Of Wildfire, Vincent J. Miller, Frederick J. Swanson, David Paul Bayles

Intersections of Science and Faith

In 2007, Catholic theologian Vince Miller had a sabbatical and went to the H.J. Andrews Experimental Forest in Oregon. In the late 1970s and early '80s, this is the place where the fundamental research was done that established old growth as a certain kind of ecological community. This emerged out of the fuel of forestry, which was largely concerned prior to that with harvest schedules and maximum sustainable yield. So, the research they did there, which was profoundly interdisciplinary, engaged the ecosystem across all sorts of disciplines. Out of that interdisciplinary work, it became a place that began to welcome …

Conformational Flexibility Is A Critical Factor In Designing Broad-Spectrum Human Norovirus Protease Inhibitors, Son Pham, Boyang Zhao, Neetu Neetu, Banumathi Sankaran, Ketki Patil, Sasirekha Ramani, Yongcheng Song, Mary K Estes, Timothy Palzkill, B V Venkataram Prasad

Faculty, Staff and Students Publications

UNLABELLED: Human norovirus (HuNoV) is a leading cause of gastroenteritis worldwide and is associated with significant morbidity, mortality, and economic impact. There are currently no licensed antiviral drugs for the treatment of HuNoV-associated gastroenteritis. The HuNoV protease plays a critical role in the initiation of virus replication by cleaving the polyprotein. Thus, it is an ideal target for developing antiviral small-molecule inhibitors. While rupintrivir, a potent small-molecule inhibitor of several picornavirus proteases, effectively inhibits GI.1 protease, it is an order of magnitude less effective against GII protease. Other GI.1 protease inhibitors also tend to be less effective against GII proteases. …

Atp-Sensitive Potassium Channels Alter Glycolytic Flux To Modulate Cortical Activity And Sleep, Nicholas J Constantino, Caitlin M Carroll, Holden C Williams, Hemendra J Vekaria, Carla M Yuede, Kai Saito, Patrick W Sheehan, J Andy Snipes, Marcus E Raichle, Erik S Musiek, Patrick G Sullivan, Josh M Morganti, Lance A Johnson, Shannon L Macauley

2020-Current year OA Pubs

Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate fluctuations are a biomarker of sleep/wake transitions, where increased interstitial fluid (ISF) lactate levels are associated with wakefulness and decreased ISF lactate is required for sleep. ATP-sensitive potassium (K

Tifab Modulates Metabolic Pathways In Kmt2a::Mllt3-Induced Aml Through Hnf4a, Yang Wang, Yan Xiu, Qianze Dong, Jinming Zhao, Kelao Neumbo, Masaru Miyagi, Nicholas Borcherding, Lin Fu, Havana De Celis, Nicolas Pintozzi, Daniel T Starczynowski, Chen Zhao

2020-Current year OA Pubs

Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein with forkhead-associated domain B (TIFAB), an inhibitor of NF-κB signaling, plays critical roles in hematopoiesis, myelodysplastic neoplasms, and leukemia. We previously demonstrated that Tifab enhances KMT2A::MLLT3-driven acute myeloid leukemia (AML) by either upregulating Hoxa9 or through ubiquitin-specific peptidase 15-mediated downregulation of p53 signaling. In this study, we show that Tifab deletion in KMT2A::MLLT3-induced AML impairs leukemia stem/progenitor cell (LSPC) engraftment, glucose uptake, and mitochondrial function. Gene set enrichment analysis reveals that Tifab deletion downregulates MYC, HOXA9/MEIS1, mTORC1 signaling, and genes involved in glycolysis and oxidative phosphorylation. By comparing genes upregulated in TIFAB-overexpressing …

Agouti And Bmp Signaling Drive A Naturally Occurring Fate Conversion Of Melanophores To Leucophores In Zebrafish, Delai Huang, Emaan H. Kapadia, Yipeng Liang, Leah P. Shriver, Shengkun Dai, Gary J. Patti, Bruno M. Humbel, Vincent Laudet, David M. Parichy

2020-Current year OA Pubs

No abstract provided.

Evaluating Zinc Deficiency As A Contributing Factor To Poor Glycemic Control In Type 2 Diabetes Iraqi Patients: A Case-Control Study", Noor Mohammed Obaid, Mustafa Mohammed Albassam, Yasser Kadhim Hashem Al-Zwaini

Maaen Journal for Medical Sciences

Background: Type 2 diabetes mellitus (T2DM) is a common metabolic disorder, characterized by chronic hyperglycemia resulting from insulin resistance and beta-cell dysfunction. One nutrient deficiency specifically associated with the progression of diabetes is that of micronutrients, especially zinc. This paper reviews the role of zinc in insulin synthesis, secretion, and action, whilst reviewing the potential interaction with oral antidiabetic drugs.

Objective: This study aimed to investigate serum zinc concentrations in T2DM patients and examine their correlation with fasting blood glucose (FBG) levels in individuals using oral antidiabetic medications.

Methods:A case-control study was conducted from March 2023 to September 2023 …

Extraterritorial Act Versus The Indigenous People Protection: An Analysis Of The European Union Deforestation-Free Regulation, Aartje Tehupeiory, Putu George Matthew Simbolon

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

At first glance, indigenous people and international trade appear to be two separate issues. However, this perception does not apply in the case of European Regulation 2023/1115. This study aims to provide an understanding of how Indonesia should respond to the EU DFR, which has affected Indonesia’s national interests in protecting indigenous people. This study applied a normative method through doctrinal and conceptual approaches to achieve the objective. The study covers two main discussions. The first explains how due diligence under the EU DFR has indirectly pushed Indonesia to become an EU trading partner and provide more excellent protection for …

Questioning Food Security In Green Constitution Conception: Realizing Sustainable Development Goals (Sdgs) In Indonesia, Rahayu Subekti, Tsabbita Ahmilul Husna, Putri Balqis Salsabila

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

Research on the constitution, food security, and sustainable development have become widely explored. However, issues related to the legal framework in the context of a green constitution remain unresolved. This is particularly evident in Indonesia’s efforts to address the food crisis, which has led to substantial deforestation. Therefore, this research aims to analyze the implementation of food security efforts in line with a green constitution in Indonesia. Despite the potential for adopting sustainability for future generations, there is hesitance in implementing articles related to a green constitution in food security activities. This legal issue is examined as normative research using …

The Inadequacy Of Legal Provisions On Workplace Sexual Harassment In Nigeria And Ghana: The Way Forward, Emuobo Emudainohwo

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

Sexual harassment has been a persistent problem in workplaces in Nigeria and Ghana. The legal provisions in both jurisdictions generally focus on the definition of “sexual harassment” without remedies for the harassment, sanctions, enforcement procedures, anti-sexual harassment policies, complaint procedures, etc., that can control sexual harassment in the workplace. The article examines the scantiness and inadequacy of legal provisions on workplace sexual harassment in Nigeria and Ghana, suggesting a way forward. The doctrinal research method has been deployed, focusing on relevant Nigerian and Ghanaian legal provisions. The article considers the organization theory of sexual harassment, using it as a framework, …

A Discourse Of The Indigenous Peoples' Rights And Their Contributions To The Indonesian Development: Lessons Learned From New Zealand, Mohamad Jamin, Sapto Hermawan, Mulyanto Mulyanto

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

The struggles of indigenous peoples in both New Zealand and Indonesia to gain legal recognition remain ongoing. This study focuses on two central aspects. Firstly, it examines the historical-legal journey of indigenous peoples in their quest for legal acknowledgment. Secondly, it makes a comparative analysis with New Zealand, highlighting the potential contributions that indigenous peoples can provide to their respective countries. The study follows a legal research methodology, linking existing issues with authoritative sources and real-world situations. The findings reveal that in New Zealand, indigenous peoples possess a legal standing, albeit not entirely comprehensive. Conversely, Indonesian regulations do not provide …

The Opportunities For Surrogacy Legalization Between The Right To Have Children And A Loophole Of Trafficking, Wawan Edi Prastiyo, Gde Made Swardhana

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

The phenomenon of producing surrogate mother facilities has been recognized in some countries, although Indonesia indirectly prohibits the practice. The practice is also feared to be a new form of human trafficking. Therefore, this study aims to evaluate the opportunities for surrogacy legalization regarding its perspectives between human rights and the loophole of trafficking. In this study, three problems were formulated: (1) the legal status of children born from a surrogate mother; (2) the legality of a surrogate mother in Indonesian law; and (3) the opportunities for surrogacy legalization in legal reform. This study is a normative juridical study that …

Human Genetic Engineering: Should Indonesia Regulate It?, Hari Sutra Disemadi

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

Human genetic engineering raises pros and cons. Despite the potential to contribute to the health sector, it can cause several problems. While, in theory, it goes against nature and against other conservative beliefs, human genetic engineering gains important support from Transhumanism—a philosophy promoting the scientific evolution of the human race. This study determines the relevancy regulation of human genetic engineering on a global scope and how it affects the prospects of regulating human genetic engineering in Indonesia. The study aims to provide consideration for Indonesia in determining the legality status of human genetic engineering, through analyses of legal constructions surrounding …

The Existence Of Indonesian National Research And Innovation Agency: The Academic Freedom’S Perspective, Muhamad Dzadit Taqwa, M. Irfan Dwi Putra, Muhamad Ali Muharam

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

Recently, Indonesia has taken a policy to merge all the research institutions, which were classified as non-ministerial institutions, into the National Research and Innovation Agency (BRIN –Badan Riset dan Inovasi Nasional). The BRIN is expected to (1) reduce the research costs for the research institutions; and (2) integrate and harmonize these institutions. On the other hand, the policy has drawn constitutional law scholars' attention. Many of them who concern that BRIN intervenes academic freedom in Indonesia. The main factor that causes the concern is the subordinate relationship between the President and the BRIN that restrain researchers from their …

Children Involvement In Terrorism Activities: Perpetrator Or A Victim? (A Study In The Circle Of Violence), Wawan Edi Prastiyo, I Ketut Rai Setiabudhi

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

Terrorism is an extraordinary crime since it violates human rights. However, it will be different if children commit it. The legal approach is not necessarily taken against children who become terrorists. The problem of children's involvement in terrorist activities does not end there. Another important issue that must also be considered is children of terrorist parents. They must be rescued from a violent social environment. In this study, we will discuss the position of children as victims in the cycle of violence of terrorism and criminal policies in overcoming the involvement of children in terrorism activities. This research is normative …

The Judicial Pardon Arrangement As A Method Of Court Decision In The Reform Of Indonesian Criminal Law Procedure, Mufatikhatul Farikhah

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

Judicial Pardon is a new concept formulated in the 2019 Draft of the Criminal Code. The concept refers to the judges’ new powers to forgive defendants who are convicted guilty. However, the formulation of the concept has not been adjusted to the formulation of decision types in the draft of the Criminal Law Procedure. There has to be a harmonization between the Draft of the Criminal Code and the Draft of the Criminal Law Procedure. This article is based on a legal study on the importance of regulating judicial pardon as a form of the court decision. It reveals that …

An Endless Struggle Of Fighting Discrimination In The Name Of Human Rights Protection, Hernadi Affandi, Tarsisius Murwadji

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

The Incident of George Floyd’s death reminds people of the peril of discrimination that still exists within the American society. The incident has triggered worldwide reactions from people who feel sympathy for the victim and reject racism. To eliminate racial discrimination, every modern society needs to remove any negative paradigm towards intergroup relation. In the context of the United States, the American Government has the responsibility to protect the rights of citizens from any forms of discrimination. That includes racial discrimination. In addition, people have to be reminiscent of the danger of racial discrimination in the modern era. The danger …

Diskursus Perumusan Ideologi Sebagai Perbuatan Pidana Dalam Rancangan Kitab Undang-Undang Hukum Pidana 2015, Rocky Marbun

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

Reformasi Hukum Pidana pasca kemerdekaan Indonesia telah dimulai sejak 1963 terhadap Kitab Undang-Undang Hukum Pidana sebagai warisan dari kolonial Belanda. Semangat kemerdekaan menginginkan adanya reformasi, bukan hanya terhadap produk hukum yang masih bernuansa kolonialisme, namun juga pada cara pandang atau pola pikir dalam memandang permasalahan hukum. Salah satu pola pikir yang mendapat pengaruh warisan kolonialisme dalam mempertahankan rust en orde (menjaga keamanan dan ketertiban) adalah dengan memasukkan instrumen hukum guna mempertahankan kestabilan politik. Sehingga negara masih memandang urgenitas dari tindakan isolasir terhadap ideologi negara dengan melakukan pelarangan terhadap penyebaran ideologi Komunisme/Marxisme/Leninisme. Faktor terbesar dari perumusan pelarangan tersebut adalah pengalaman hitam …

Dampak Ketiadaan Pengaturan Kuota Ekspor Hiu Tikus (Alopias Ssp.) Di Indonesia, Wahyu Hardiningsih, Hari Purwadi, Emmy Latifah

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

Kuota ekspor merupakan salah satu mekanisme perlindungan ekosistem laut. Banyaknya perburuan Ikan Hiu Tikus (Alopias Ssp.) di Indonesia saat ini karena permintaan pasar yang tinggi, khususnya dari luar negeri. Tingginya permintaan menyebabkan ikan jenis ini masuk ke dalam daftar Convention on International Trade in Endanger Species of Wild Fauna and Flora (CITES) Appendiks II pada tahun 2016. Jika Ikan Hiu Tikus yang merupakan predator puncak pada rantai makanan di laut ini sampai terancam punah, maka ekosistem laut akan mengalami kerusakan parah. Hasil penelitian menunjukkan bahwa Indonesia belum memiliki perangkat hukum yang memadai terkait dengan penentuan komponen-komponen kuota ekspor …

Book Review: Marine Protected Areas In International Law: An Arctic Perspective, Davina Oktivana

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

Marine biodiversity has always become an interesting topic in the development of the law of the sea subject. Despite of human dependence on marine resources, human intervention has been proven as the major threats to the sustainability of marine biodiversity and marine environment protection. Human activities, such an over-exploitation, shipping pollution, the use endangered fishing tools and above all, climate change, have changes the ecosystems extensively. One of the significant measures to prevent broaden the catastrophe is the establishment of Marine Protected Areas (MPAs), which has been accepted as a tool for protection and conservation of marine biodiversity. The book …

Rekonsepsi Model Pencegahan Dan Pemberantasan Illegal Fishing Di Indonesia, Muh. Risnain

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

Pencegahan dan pemberantasan illegal fishing di Indonesia adalah isu hukum yang masih dapat diperdebatkan hingga kini. Dibalik popularitas kebijakan pencegahan dan pemberantasan illegal fishing ternyata masih menimbulkan masalah yang masih diperdebatkan baik secara teoritis maupun praktikal. Model kebijakan pencegahan dan pemberantasan illegal fishing yang dilakukan dengan penenggelaman kapal dan penangkapan kapal asing masih menghadapi persoalan yang harus diselesaikan dengan sebuah model pencegahan dan pemberantasan illegal fishing secara komprehensif dan terkoordinasi. Model baru tersebut untuk menyempurnakan model yang ada sekarang dengan dukungan pada pemodelan kelembaagaan, pengayaan rezim hukum, kerjasama internasional, dan koordinasi dengan lembaga penegakan hukum perikanan di daerah.

The Re-Conception …

Peningkatan Ketahanan Keluarga Melalui Optimalisasi Pola Asuh Maternalistik Dalam Pencegahan Kejadian Pedofilia, Trini Handayani

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

Abstrak

Peningkatan kasus kekerasan seksual pada anak (pedofilia) merupakan permasalahan dalam perlindungan anak. Pada beberapa kasus pedofilia yang terungkap, pelaku pedofilia mengalami pola asuh keluarga yang menyimpang. Artikel ini mengungkap fakta-fakta kasus pedofilia di Indonesia, dampak dan persoalan hukumnya, serta peran keluarga melalui pola asuh sebagai upaya pencegahan. Pengetahuan tentang ragam kekerasan pada anak menjadi penting bagi masyarakat dan penegak hukum. Pola asuh maternalistik diharapkan juga dapat membantu mengurangi kasus pedofilia dan mencegah munculnya pedofil baru. Pencegahan terhadap kasus pedofilia dimulai dari keluarga dengan mengoptimalkan pola asuh oleh ibu atau pengganti ibu dalam keluarga sehingga anak mengetahui dan dapat menolong …

Status Hukum Sumber Daya Alam Di Luar Jurisdiksi Nasional Dan Posisi Negara Maju Di Bidang Keantariksaan, Mardianis Mardianis

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

Abstrak

Pengaturan kepemilikan dan penggunaan sumber daya alam di luar jurisdiksi nasional selalu menjadi perebutan dan perdebatan antara negara maju dan negara berkembang. Sampai saat ini sudah disahkan tiga rezim hukum internasional khusus yang berlaku untuk tiga wilayah sumber daya alam, yaitu Antartika, Laut Bebas khusus Dasar Laut Dalam, dan Antariksa khususnya Bulan. Ketiga rezim tersebut menggunakan konsepsi ‘common heritage of mankind/warisan bersama umat manusia’ sebagai prinsip utama pengaturannya. Tulisan ini dengan menggunakan metode penelitian normatif dan komparatif akan meneliti secara rinci variasi penerapan prinsip tersebut serta posisi negara maju di bidang keantariksaan terkait pemberlakuan rezim tersebut. Pada …

Urgensi Revisi Undang-Undang Landas Kontinen Indonesia, Davina Oktivana

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

Pengaturan mengenai landas kontinen di Indonesia khususnya dalam menentukan batas terluar landas kontinen masih mengacu pada ketentuan Konvensi Jenewa tentang Landas Kontinen tahun 1958, yaitu menggunakan kriteria kedalaman dan kemampuan dalam melakukan eksploitasi. Sementara Indonesia telah meratifikasi Konvensi Hukum Laut 1982, dimana kriteria dalam menentukan batas terluar landas kontinen berdasarkan konvensi ini dinilai lebih menguntungkan bagi negara pantai. Keuntungan yang dimaksud adalah penggunaan kriteria topografi dasar laut dan diperbolehkannya negara pantai mengajukan perpanjangan landas kontinen. Indonesia telah mengajukan submisi perpanjangan landas kontinen yang berlokasi di barat laut Sumatera pada tahun 2008 dan disetujui oleh Komisi Batas-Batas Landas Kontinen PBB pada …

Khazanah: Friedrich Karl Von Savigny, Atip Latipulhayat

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

Friedrich Karl von Savigny (1779-1861) adalah ahli hukum Jerman yang juga dianggap sebagai salah satu Bapak hukum Jerman. Savigny adalah tokoh mazhab sejarah (historical school jurisprudence ) yang dikembangkannya pada paruh pertama abad ke 19. Dia juga dianggap sebagai pelopor kajian mengenai relasi antara perkembangan hukum dan sosial. Sebagai seorang pemikir hukum yang senantiasa kreatif dalam membuat terobosan-terobosan (trail-blazing legal scientist), Savigny memberikan kontribusi penting dalam perkembangan ilmu hukum dan bahkan terhadap ilmu sosial. Dari sekian banyak kontribusinya antara lain teorinya mengenai kontinuitas antara institusi hukum saat ini dengan institusi hukum masa lalu, meletakkan fondasi bagi kajian sosiologi hukum, dan …