Digital Commons Network^™

Cascades, A Novel Sox2 Super-Enhancer-Associated Long Noncoding Rna, Regulates Cancer Stem Cell Specification And Differentiation In Glioblastoma, Uswa Shahzad, Marina Nikolopoulos, Christopher Li, Michael Johnston, Jenny J Wang, Nesrin Sabha, Frederick S Varn, Alexandra Riemenschneider, Stacey Krumholtz, Pranathi Meda Krishnamurthy, Christian A Smith, Jason Karamchandani, Jonathan K Watts, Roel G W Verhaak, Marco Gallo, James T Rutka, Sunit Das

Faculty, Staff and Students Publications

Glioblastoma is the most common primary malignant brain tumor in adults, with a median survival of just over 1 year. The failure of available treatments to achieve remission in patients with glioblastoma (GBM) has been attributed to the presence of cancer stem cells (CSCs), which are thought to play a central role in tumor development and progression and serve as a treatment-resistant cell repository capable of driving tumor recurrence. In fact, the property of "stemness" itself may be responsible for treatment resistance. In this study, we identify a novel long noncoding RNA (lncRNA), cancer stem cell-associated distal enhancer of SOX2 …

Humans Are Far Dearer Than Gold, Richard Gorban

Occasional Papers on Religion in Eastern Europe

The author of the article proves that the genocidal war of the Russian Federation against Ukraine is aimed at the total destruction of both the Ukrainian nation and its culture, based on the methodological principle of actualizing biblical texts in the current circumstances and by selecting elements from the exhaustiveness of the content of the Book of Isaiah, the Prophet, which are able to reveal the ontological foundations of this war. It is the clash between the two incompatible experiences of existence: the existence of a human community in peace and that of a community in war. Ukraine has become …

Bisecting Science Through The Use Of Art, Joyce Ymoniak

Professional Learning Day

Participants will discover, through art and drawing, how students can understand the inner workings and parts of a bisected specimen. In this hands-on session, we will explore the inner workings of an Indigenous plant. We will also explore the use of both low- and high-end technology within a classroom. Takeaways will include concepts and hands-on activities for use in grades 6-12.

Medicine In Chemistry, Dr. John Thurmond

Professional Learning Day

In this session, participants analyze medicines through simple chemical tests that reveal characteristics like solubility and reactivity. Observing reactions, such as color changes, helps participants understand how basic chemical principles are used to distinguish between different compounds. These activities build practical skills for applying chemistry in contexts like quality control and forensic analysis.

Nsf Ret Program:Integrating Sciencecurriculum, Lassandra Walker, Sarah O’Leary Driscoll

Professional Learning Day

NSF RET Program offers teachers an opportunity to develop a science curriculum. The aim of the curriculum is to demonstrate how the integration of science develops science thinkers and allows students to participate in experimental learning through investigations. Instructor to get students thinking through alternative logics and to see how thought was formed in specific cultural and historical contexts.

Small Streams Of Teaching Practice, Jonathan Litten

Essays in Education

No abstract provided.

Real-World Examples For Engaging Students In Chemistry, Dr. Angela Ahrendt, Dr. Jane Proszek Gorninski

Professional Learning Day

What do consumer electronics, water treatment, and cooking all share? Chemistry! Use real-world examples to engage students in introductory chemistry topics such as the periodic table, bonding, chemical reactions, etc. This session will have an interactive discussion about how chemistry is important in everyday life and provide examples of activities and projects you can use in your classroom. Please share at least one idea about how you use real-world examples in your class.

The Epistemic Responsibility Of 1930s Eugenicists: What The Trial Of Ann Cooper Hewitt Shows About Modern Disinformation Discourse, Lia Richter

Binghamton University Undergraduate Journal

In this paper, the author analyzes the 1936 eugenic sterilization trial surrounding Ann Cooper Hewitt, looking at the epistemic harms and wrong associated with the results and how those connect to modern day discourses of disinformation. It centers on the actions of two eugenicists involved, Ezra S. Gosney and Paul Popenoe.

Helping Students Understand The Complexity Of Ecological And Environmental Issues Through Use And Creation Of Environmental Impact Statements, Jessica Amacher, Desirae Klimek

Professional Learning Day

When discussing environmental issues, threats to ecosystems, and potential solutions, students tend toward a simplified view of these issues and how to fix them. To enrich their understanding of the complexities of these problems and the potential for real-life solutions, we developed a unit in which students create Environmental Impact Statements. This framework encourages students to consider the diverse perspectives of stakeholders in a specific ecosystem and to propose feasible and effective solutions.

Teaching With A Full Deck: Card Activities In Mathematics, Lindsey Herlehy

Professional Learning Day

Card sorts encourage students to do what we value most: talk and reason. Beyond simple matching, card sorts allow students to classify, rank, sequence, and map out ideas, creating a natural context for critical thinking and discussion. Join me for a series of math-focused card sorts where students will engage in activities like sorting equations by type, sequencing steps for solving multi-step problems, analyzing characteristics of graphs, and collaborating to solve clothesline math problems. This easy-to-prep tool will help students deepen their understanding of math concepts, fostering algebraic reasoning, graph analysis, and collaborative problem-solving skills.

Monstrous Feminine, Deviant Mother: Tolkien’S Shelob And The Grotesque Maternal, Sara Brown

Journal of Tolkien Research

J.R.R. Tolkien’s menacing character of Shelob embodies the ultimate danger that faces Frodo on his journey to destroy the Ring of Power. Her actions, in combination with the language that Tolkien uses to describe her, invite the reader to view Shelob with revulsion and horror, designating her as Other. However, Shelob is also undeniably a mother, a term laden with social and cultural expectation. This paper explores Shelob as a representation of what Barbara Creed, in her article “Horror and the Monstrous-Feminine: An Imaginary Abjection”, has termed the ‘monstrous-feminine’, examining Shelob’s presentation within the text as not only identified as …

Risk Factors Associated With Worse Outcomes In Trauma Patients Aged 55 And Older, Hector Mendez, Ilko Luque, Nicole Yordán López, Carlos Parra, Kelvin Chan, Mariel A. Javier, Marcela Ramirez, Orlando Morejón

HCA Healthcare Journal of Medicine

Background

Prior studies have shown an increase in mortality in trauma patients after 55 years of age. However, it is less certain which pre-existing comorbidities (PECs) are associated with poorer outcomes. The purpose of this study was to identify the risk factors associated with poor outcomes and death in patients 55 years old and older admitted for trauma.

Methods

Trauma patients (age ≥ 55) were studied retrospectively from the local trauma registry at HCA Florida Kendall Hospital, a level 1 trauma center (2020–22). We collected the subject’s age, gender, PECs, and outcome data. Then we performed multiple logistic regression to …

Synthetic Versus Biologic Mesh For Complex Open Ventral Hernia Repair: Three-Year Follow-Up Of A Pilot Randomized Controlled Trial, Nalia H. Dhanani, Nicole B. Lyons, Kyung Hyun Lee, Oscar A. Olavaarria, Aris R. Arakelians, Julie L. Holihan, Lillian S. Kao, Ali Siddiqui, Connor Hogan, Tunmi Anwoju, Zuhair Ali, Mike K. Liang

HCA Healthcare Journal of Medicine

Background

Biologic mesh is often used in complex hernia repair, but there has been limited clinical evidence to date to support this practice. The aim of this study was to compare clinical and patient-reported outcomes of biologic versus synthetic mesh for complex open ventral hernia repair (OVHR) at 3 years.

Methods

Patients from a single center, randomized, controlled, pilot trial comparing biologic versus synthetic mesh in complex OVHR were followed for 3 years. The primary outcome focused on major complications, namely mesh infections, hernia recurrences, reoperations, and deaths. Secondary outcomes included surgical site infections, surgical site occurrences, and patient-reported outcomes. …

Analysis Of Prey, Predator And Top Predator Model Involving Various Functional Responses, Divya B., K. Kavitha

Baghdad Science Journal

This research proposes a mathematical model to investigate the dynamical behavior of the system of three species, namely prey, predator and top predator. The feeding behavior of each predator serves as a functional response. The interaction between the species is carried out by a functional response. Crowley Martin functional response is incorporated between prey and predator while Holling type III functional response occurs between predator and top predator. The existence of positivity and boundedness of the system have been examined. The equilibrium points of the system are determined. The system has been linearized by applying the Jacobian matrix. The main …

Hopf And Zero-Hopf Bifurcation Of The Four-Dimensional Lotka-Volterra Systems, Sirwan A. Mustafa, Niazy H. Hussen

Baghdad Science Journal

In this work, the four-dimensional Lotka-Volterra model (4DLV) involving four species in a constant environment is considered. The objective of this investigation is to study the local bifurcations occurring in the system. This system has at most sixteen possible equilibrium points. One of the equilibrium points is considered in order to investigate the periodic solutions that bifurcate from the Hopf and the zero-Hopf equilibrium points, respectively. It has been proven that, five families of sufficient conditions exist on the parameters of the system in which the Jacobian matrix at equilibrium point has a pair of purely imaginary ± iω …

Predation Of The Scorpion Hottentotta Saulcyi (Scorpiones: Buthidae) By The Long-Eared Hedgehog (Hemiechinus Auritus) (Mammalia: Eulipotyphla: Erinaceidae) In Şırnak Province, Türkiye, Rıdvan Kurt, Ersen A. Yağmur, Tarkan Yorulmaz

Euscorpius

In this study, we report the predation of Hottentotta saulcyi (Simon, 1880) by the insectivorous mammal Hemiechinus auritus (Gmelin, 1770) in Şırnak Province, southeastern Türkiye. During a nighttime field trip, we observed a long-eared hedgehog biting a H. saulcyi individual on its prosoma. This observation confirms that long-eared hedgehogs feed on and prey upon scorpions.

Fluorescence Lifetime Imaging Ophthalmoscopy (Flio): A Novel Retinal Metabolic Biomarker For Multiple Sclerosis, Daniel Markowitz, Kylee Shivok, Elizabeth Affel, Ms, Jose S. Pulido, Md, Ms, Mba, Mph, Thomas P. Leist, Md, Phd, Gyorgy Hajnoczky, Md, Phd, Mahdi Alizadeh, Phd, Robert Sergott, Md

Farber Institute for Neuroscience Staff Papers and Presentations

Introduction

- Fluorescence lifetime imaging ophthalmoscopy (FLIO, Heidelberg Engineering, Figures 1 and 2), a novel in vivo retinal imaging biomarker, generates fluorescence decay lifetimes in 2 spectral channels corresponding to the following metabolic processes:

- Short Spectral Channel (SSC): 498 – 560 nm

• Corresponds to macular pigment, flavin adenine dinucleotide (FAD) and oxidative phosphorylation.

- Long Spectral Channel (LSC): 560 – 720nm

• Corresponds to predominantly lipofuscin and lysosomal function

- Based upon animal experimental models and clinical data, mitochondrial dysfunction has a role in the pathophysiology of both inflammatory and degenerative components of Multiple Sclerosis

The Student Movement Volume 109 Issue 16: New Months, New Movies, New Celebrations, Esther Martin, Ember Clark, Melanie Webb, Corinna Bevier, Nate Miller, Reagan Mccain, Andrew Francis, Melissa Moore, Natalie Reid, Amelia Stefanescu

The Student Movement V. 109 (2024-2025)

HUMANS

The Unity of Deliverance Mass Choir, Esther Martin

ARTS & ENTERTAINMENT

Save Your Time and Don't Watch "Captain America: Brave New World", Ember Clark

Celebrating Cinema's Indie Spirit, Melanie Webb

We Watched Every 2024 Best Picture Nominee (So You Don't Have To), Corinna Bevier and Nate Miller

My Life As a Student Radio Announcer (the Coolest Job on Campus), Reagan McCain

NEWS

Elegance and Beauty on Display at BSCF's Jazzy Soiree, Andrew Francis

2nd Annual Andrews University Indoor Triathlon, Melissa Moore

IDEAS

Are We Dying for Food Dyes?, Natalie Reid

PULSE

Volunteering Opportunities In the Berrien Area, Amelia Stefanescu …

A Natural Law Approach To Parental Rights, Richard A. Epstein

The Journal of Contemporary Legal Issues

The modern interest in the twin cases of Meyer v. Nebraska, and Pierce v. Society of Sisters has sparked a renewed curiosity in the intellectual foundations and current applicability of those two cases. In this instance, I stress less the constitutional underpinnings of the cases in order to focus more on their natural law approach to the parent-child relationship. Based on Lockean principles, I conclude that the standard rules of abuse and neglect offer the sole justification for such intervention, where the state is put to a high standard of proof for intervention. This framework has had only an …

Meyer, Pierce, And The Formation Of Persons, Steven D. Smith

The Journal of Contemporary Legal Issues

This essay, written for a conference marking the centennial of the Supreme Court’s decisions in Meyer v. Nebraska (1923) and Pierce v. Society of Sisters (1925), suggests that both the ongoing importance and the frustrating elusiveness of these decisions reflect the fact that questions of the formation of persons– as contrasted with matters of the expression or manifestation of personhood– are of crucial importance in the protection of liberty and yet are difficult to grasp and address within constitutional and liberal premises. In this predicament, the decisions dealt with the problem of formation of personhood by embracing what may be …

Mired In Meyer’S Mischief A Century After Fabrication Of Constitutional Parents’ Rights, James G. Dwyer

The Journal of Contemporary Legal Issues

The seminal Supreme Court decisions Meyer v. Nebraska and Pierce v. Society of Sisters, now commemorated on their centenary anniversary, are odd doctrinal ducks. They are both still routinely cited as the foundation for ascribing to persons on whom the state has conferred legal parent status a right under the Fourteenth Amendment Due Process Clause of the United States Constitution. (According to Westlaw, judicial citation count for Meyer now nears 3000, and secondary-source citations have surpassed 7000.) It is a constitutional right to force states to confer on them greater legal power than the state is otherwise inclined to …

Edge Feathering Across Forest-Meadow Ecotones Increases Light Heterogeneity And Understory Plant Diversity, Aruni Kadawatha, Jean H. Burns

Faculty Scholarship

Ecotones, the transitional zones between distinct habitats, are vital for ecosystem functioning and habitat diversity. Traditional management practices frequently create abrupt boundaries, leading to stressful conditions for organisms. To address this challenge, an underutilized land management technique called “edge feathering”, which involves gradual thinning of the canopy along the forest edge, has been introduced. This study, con- ducted at Holden Arboretum in Kirtland, Ohio, investigated the effects of edge feathering on light availability and understory plant diversity in edge feathered and control treatments. We calculated the coefficient of variation in light availability as light heterogeneity and plant diversity indices at …

Examination Of Protective Factors That Promote Prosocial Skill Development Among Children Exposed To Intimate Partner Violence, Megan R. Holmes, Anna E. Bender, Kristen A. Berg, Kylie E. Evans, Amy Korsch-Williams, Adam T. Perzynski

Faculty Scholarship

This retrospective cohort study examined prosocial skills development in child welfare-involved children, how intimate partner violence (IPV) exposure explained heterogeneity in children's trajectories of prosocial skill development, and the degree to which protective factors across children's ecologies promoted prosocial skill development. Data were from 1,678 children from the National Survey of Child and Adolescent Well-being I, collected between 1999 and 2007. Cohort-sequential growth mixture models were estimated to identify patterns of prosocial skill development between the ages of 3 to 10 years. Four diverse pathways were identified, including two groups that started high (high subtle-decreasing; high decreasing-to-increasing) and two groups …

Rotating Hinge Vs. Total Condylar “When To Decide”: A Surgical Algorithm, Benjamin Huang, Russell T. Nevins

Annual Research Symposium

Research symposium for general health topics

Enhancing Periodontal Therapy With Non-Invasive Adjunctive Techniques A Comparative Literature Review, Stockton Stohl, Kamran H. Awan

Annual Research Symposium

No abstract provided.

2025 Qdayton Colloquium Program, University Of Dayton

QDayton Documents

Program for the fourth annual QDayton Colloquium, Feb. 28, 2025

The Minutes Of The Marshall University Graduate Council Meeting, February 28, 2025, Marshall University Graduate Council

Graduate Council Minutes

No abstract provided.

Reduction Of Prostate Cancer Risk: Role Of Frequent Ejaculation-Associated Mechanisms., Mohamed Hassan, Thomas W. Flanagan, Abdulaziz M. Eshaq, Osama K. Altamimi, Hassan Altalag, Mohamed Alsharif, Nouf Alshammari, Tamadhir Alkhalidi, Abdelhadi Boulifa, Siraj M. El Jamal, Youssef Haikel, Mossad Megahed

School of Medicine Faculty Publications

Simple Summary: There is considerable evidence to suggest that frequent ejaculation reduces the risk of prostate cancer. The more frequently ejaculation occurs without risky sexual behavior, the lower the risk of prostate cancer. The mechanisms regulating the reduction in PCa risk associated with frequent ejaculations are attributed to the suppression of the sympathetic nervous system, resulting in a relief of tension and a slowing of the division of prostate epithelial cells. It is suggested that ejaculation frequency affects gene expression in prostate tissue and subsequently influences the susceptibility of the tissue to tumor formation, leading to a reduction in the …

Fructose Induces Inflammatory Activation In Macrophages And Microglia Through The Nutrient-Sensing Ghrelin Receptor, Zheng Shen, Zeyu Liu, Hongying Wang, Danilo Landrock, Ji Yeon Noh, Qun Sophia Zang, Chih-Hao Lee, Yuhua Z Farnell, Zheng Chen, Yuxiang Sun

Faculty, Staff and Student Publications

High fructose corn syrup (HFCS) is a commonly used sweetener in soft drinks and processed foods, and HFCS exacerbates inflammation when consumed in excess. Fructose, a primary component of HFCS; however, it is unclear whether fructose directly activates inflammatory signaling. Growth hormone secretagogue receptor (GHSR) is a receptor of the nutrient‐sensing hormone ghrelin. We previously reported that GHSR ablation mitigates HFCS‐induced inflammation in adipose tissue and liver, shifting macrophages toward an anti‐inflammatory spectrum. Since inflammation is primarily governed by innate immune cells, such as macrophages in the peripheral tissues and microglia in the brain, this study aims to investigate whether …

Psychosocial Burden And Suicidality In Epilepsy: A Public Health Concern, Martha Sajatovic

Faculty Scholarship

The increased risk for psychosocial burden and suicidality in people with epilepsy compared to the general population is a well-established global public health concern. Suicidality risk is also increased in patients with functional seizures. The timely identification of patients at highest risk for psychosocial burden and self-harm is vital. This can pose a significant challenge for multidisciplinary clinicians caring for people with epilepsy. Early identification of social stressors and comorbid psychiatric contributors via screening are required to assist with the development of predictive models for self-harm in epilepsy; and subsequent options for treatment and the provision of adjunct supports in …