Digital Commons Network^™

Barriers And Breakthroughs In The Evolution Of Aggregative Multicellularity, Israt Jahan

Arts & Sciences Graduate Student Theses and Dissertations

The evolution of multicellular organization represents a key innovation in the history of life, yet fundamental questions remain about the evolutionary mechanisms that allowed some lineages to achieve remarkable complexity, while constrained others in their elaboration. The widely accepted single-cell bottleneck model provides a compelling explanation for the success of clonal multicellularity by reducing internal conflict and facilitating developmental integration. However, this perspective does not fully account for the stability and repeated evolution of aggregative multicellularity, where cooperation emerges among previously independent cells that may not be genetic relatives. Aggregative multicellularity demonstrates that the evolution of multicellularity is not a …

Mesenchymal Stem Cells Loaded In Injectable Alginate Hydrogels Promote Liver Growth And Attenuate Liver Fibrosis In Cirrhotic Rats, Dominic Karl M Bolinas, Allan John R Barcena, Archana Mishra, Marvin R Bernardino, Vincent Lin, Francisco M Heralde, Gouthami Chintalapani, Natalie W Fowlkes, Steven Y Huang, Marites P Melancon

Faculty, Staff and Student Publications

Cirrhosis, a marker of severe liver diseases, limits future liver remnant (FLR) growth, preventing many cancer patients from undergoing surgery. While portal vein blockade (PVB) techniques are used to stimulate liver regeneration, 20-30% of patients still fail to achieve the required growth. Although mesenchymal stem cell (MSC) therapy improves PVB, its efficacy is limited by poor cell retention. To address this, we utilized alginate hydrogels to deliver MSCs and improve their retention. MSCs were loaded in the hydrogel and injected intraportally in cirrhotic rats. Liver volume, weights, enzyme levels, and histology were monitored. Results showed that the hydrogel maintained 89.0 …

The Mechanistic Target Of Rapamycin Mediates Clostridium Perfringens-Induced Chicken Necrotic Enteritis Attenuated By Secondary Bile Acid Deoxycholic Acid, Mohit Bansal, Tahrir Alenezi, Ying Fu, Janashrit Shrestha, Ayidh Almansour, Hong Wang, Anamika Gupta, Rohana Liyanage, Xiaolun Sun

Poultry Science Faculty Publications and Presentations

Clostridium perfringens is a prevalent gut bacterial pathogen in humans and animals. This study investigated the role of the mechanistic targets of rapamycin (mTOR) and deoxycholic acid (DCA) on C. perfringens intestinal infection. Chickens were sequentially infected with Eimeria maxima and received the mTOR inhibitor rapamycin and DCA. C. perfringens-induced necrotic enteritis (NE) was evaluated using body weight gain (BWG), histopathology, bile acids, pathogen colonization, cell infiltration and death, and gene expression. The significant difference of p < 0.05 was analyzed by one-way ANOVA and multiple comparisons. Notably, rapamycin strongly reduced the subclinical and clinical NE histopathologies. DCA and DCA combined with rapamycin alleviated clinical NE and BWG loss. Rapamycin, DCA, and DCA + rapamycin attenuated bile acid reduction in NE birds, and they also reduced immune cell infiltration into the intestinal lamina propria as well as immune cell migration in vitro. At molecular levels, DCA and DCA + rapamycin reduced proinflammatory IFN gamma, MMP9, IL23, and IL17 gene expression. Rapamycin, DCA, and DCA + rapamycin reduced NE-induced intestinal cell apoptosis. Together, these results suggest that mTOR signaling mediates C. perfringens-induced ileitis, and combining mTOR inhibition and DCA improves the intervention efficacy against NE ileitis and BWG loss.

March 27, 2025, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Genomics Yields Biological And Phenotypic Insights Into Bipolar Disorder, Kevin S. O’Connell, Maria Koromina, Tracey Van Der Veen, Toni Boltz, Ney Alliey Rodriguez

School of Medicine Publications

Bipolar disorder is a leading contributor to the global burden of disease¹. Despite high heritability (60–80%), the majority of the underlying genetic determinants remain unknown². We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.8 million controls), combining clinical, community and self-reported samples. We identified 298 genome-wide significant loci in the multi-ancestry meta-analysis, a fourfold increase over previous findings³, and identified an ancestry-specific association in the East Asian cohort. Integrating results from fine-mapping and other variant-to-gene mapping approaches identified 36 credible genes …

Constructivism Made Easy Using The Consider, Construct, Confirm Learning Cycle, Timothy E. Goodwin Ed.D

Essays in Education

Shifting from didactic, teacher-led instruction to a student-centered, constructivist classroom is often a daunting task for teachers. The Consider, Construct, Confirm Learning cycle is a framework for teachers to organize their planning—be it individual lessons, units of study, or whole courses. The CCC Learning Cycle framework shifts the format of a typical lesson from didactic instruction leading to short-term renting of knowledge through memorization, to student-centered, lived experiences resulting in students owning their new knowledge.

Parrotfeather (Myriophyllum Aquaticum): Biology And Management Options In Utah, Francielli S. De Oliveira

Spring Runoff Conference

Parrotfeather (Myriophyllum aquaticum)

• Invasive weed from South America.
• Heterophilic perennial dioecious plant (female in the US).
• Forms dense mats, blocks waterways, and outcompetes native species
• Spreads via rhizomes, stolons, and stem fragments.

The True Beauty Of Being Bitten By A Tick, Dereck Daschke

Journal of Religion & Film

This is a film review of The True Beauty of Being Bitten by a Tick (2025), directed by Pete Ohs.

The Impact Of Obesity Vs Non-Obesity Body Mass Index (Bmi) On Adalimumab Efficacy In Ulcerative Colitis, Mekhala Santebennur, Kathryn Mozzochi, Diana Gavilanes Md, Evelyn J. Calderon Martinez Md, Anas Atrash Md

Tower Health Research Day

No abstract provided.

The Shorthorn: December 17, 1929

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: November 05, 1929

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: October 08, 1929

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: May 28, 1929

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: April 30, 1929

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: April 23, 1929

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: April 02, 1929

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: April 09, 1929

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: February 26, 1929

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: February 19, 1929

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: January 29, 1929

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: January 15, 1929

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

Harvest Management And Regrowth Of Trifolium Alexandrinum, R E. Joost, J D. Mooso

IGC Proceedings (1977-2023)

Adaptation of berseem clover (Trifolium alexandrinum) beyond the coastal regions of the southeastern United States was limited by a lack of cold tolerance prior to the release of 'Bigbee', a selection from a stand of 'Sacromonte' subjected to temperature of -15 and -18 Con successive nights in 1972. The release of Bigbee in 1985 expanded the range of berseem clover adaptation to include the entire Southeast, as far north as Oklahoma (Knight, 1985). It is known that annual clovers do not rely on root reserve carbohydrates, but rather on residual leaf area and rapid leaf regeneration from active …

The Anorexigenic Peptide Nesfatin-1 Dampens The B Cell Response To Receptor-Mediated Stimulation Through Inhibition Of Nf-Kb Signaling, Tara L. Steffen, Joshua D. Stafford, Colleen R. Boche, Willis K. Samson, Gina Yosten

Biological Sciences Faculty Research & Creative Works

Nesfatin-1, a posttranslational product of the protein encoded by the nucleobindin 2 gene (NUCB2), was functionally identified as an appetite regulatory molecule in rat hypothalamic nuclei. In the years following the discovery, those findings have been corroborated and expanded upon, and we now know that nesfatin-1 is expressed throughout peripheral tissues and exerts physiological effects beyond feeding control. Literature indicates that adipose tissue is one of the peripheral sources of NUCB2/nesfatin-1, and in this setting, it has anti-inflammatory effects that have recently been implicated in regulating chronic inflammation associated with diet-induced obesity. Currently, there are gaps in our understanding of …

Fs Agenda 2025-03-26, Northern Illinois University

Faculty Senate Archives

No abstract provided.

Visible Learning: Adapting Primary And Secondary Pedagogical Approaches To Legal Education, Dawn Young

Journal of Legal Education

No abstract provided.

Nurses' Knowledge And Attitudes Towards The Healthcare Needs Of Transgender Persons, Christopher Brooks

ETD Collection

No abstract provided.

Marine Heatwave Conditions In Western Australia Marine Waters - 26th March 2025, Department Of Primary Industries And Regional Development, Western Australia

Marine Heatwave Notification Reports

Marine heatwave (MHW) conditions across the state have persisted. Category 1 – Moderate conditions continue for the Gascoyne and South Coast Bioregions. The North Coast Bioregion has returned to Category 1 – Moderate conditions. The West Coast Bioregion remains warm but is not categorised as experiencing MHW conditions.

Who’S Asking?: Perception, Success, And Negotiation Dynamics In Library Acquisitions, Amy Pham

Copley Library: Faculty Scholarship

“Women don’t ask.” The titular phrase of a groundbreaking work from Linda Babcock and Sara Laschever that cemented the popular belief that women are bad negotiators. But are women bad negotiators? Does the gender divide in negotiations intersect with a racial divide? In a field defined by its history of feminization and white women majority, how does this affect librarians? This presentation will draw a line through two decades of literature to examine trends of negotiation outcomes currently underrepresented in library research and share the results of an interview study exploring experiences in academic library acquisition negotiations.

The Present And Future Of Ai: Ethical Issues And Research Opportunities, Ankita Srivastava, Marco Marabelli, Danielle Blanch-Hartigan, Jeffrey Moriarty, Evan Carey

Computer Information Systems Faculty Publications

Healthcare is currently a fast-changing industry with AI and generative AI (GenAI) playing a prominent role in the transformation of clinical as well as managerial practices. Clinical practices involve AI to diagnose diseases and develop new drugs and compounds, while managerial practices concern AI-supporting processes such as billing patients and insurance companies, handling electronic medical records, and supporting remote connections with patients, increasingly using virtual and augmented reality. Yet, all these opportunities offered by AI come with challenges involving potential ethical issues, such as discrimination, bias, lack of accessibility, and privacy issues. In March 2024, we organized a panel with …

Ocular Surface Glycocalyx In Health And Disease, Rafael Martínez-Carrasco, Ajay Sharma

Pharmacy Faculty Articles and Research

The glycocalyx is a dynamic carbohydrate-enriched structure that forms a dense coating on the surface of animal cells, including those at the ocular surface. It plays a critical role in maintaining cellular functions and it has a significant influence in disease processes. At the ocular surface, glycoproteins such as mucins are essential for hydration, lubrication, and barrier protection. Proteoglycans and glycolipids contribute to cell signaling, and mediate interactions with pathogens. Alterations in the glycocalyx are implicated in a spectrum of ocular conditions, including dry eye disease, ocular allergies, infections, and systemic diseases such as Graft-versus-host disease (GVHD) and diabetes mellitus. …