Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2025

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 31621 - 31623 of 31623

Full-Text Articles in Entire DC Network

Association Of High-Sensitivity Cardiac Troponin I Levels Below The Sex-Specific 99th Percentile With Late-Life Dementia: The Perth Longitudinal Study Of Ageing Women, Carlos J. Toro-Huamanchumo, Abadi Kahsu Gebre, Tiago Pecanha, Craig Sale, Wai Lim, Elizabeth Byrnes, Ee Mun Lim, Simon Laws, Kun Zhu, Carl Schultz, Richard L. Prince, Blossom C.M. Stephan, Mario Siervo, Joshua R. Lewis, Marc Sim Jan 2025

Association Of High-Sensitivity Cardiac Troponin I Levels Below The Sex-Specific 99th Percentile With Late-Life Dementia: The Perth Longitudinal Study Of Ageing Women, Carlos J. Toro-Huamanchumo, Abadi Kahsu Gebre, Tiago Pecanha, Craig Sale, Wai Lim, Elizabeth Byrnes, Ee Mun Lim, Simon Laws, Kun Zhu, Carl Schultz, Richard L. Prince, Blossom C.M. Stephan, Mario Siervo, Joshua R. Lewis, Marc Sim

Research outputs 2022 to 2026

Background: Elevated high-sensitivity cardiac troponin (hs-cTn) levels are linked with cardiovascular disease and cognitive impairment, both of which are strong risk factors for late-life dementia (LLD). This study examined the association between hs-cTnI levels below the sex-specific 99th percentile for myocardial injury and the incidence of LLD in older women. Methods: 986 community-dwelling women aged ≥70 years without prior LLD and with hs-cTnI < 15.6 ng/L (stratified into quartiles) were included from the Perth Longitudinal Study of Ageing Women. The primary outcome was incident LLD events, including LLD hospitalisation or death, over 14.5 years obtained from linked health records. Associations between hs-cTnI and LLD outcomes were explored using multivariable-adjusted Cox models, as part of restricted cubic splines. Results: At baseline, participants' mean (±SD) age was 75.2±2.7 years. Over 14.5 years of follow-up, LLD events (n=174, 17.7%), hospitalisations (n=155, 15.7%) and deaths (n=68, 6.9%) were recorded. Compared with those in the lowest quartile (Q1, median 3.1 ng/L), women in the highest quartile of hs-cTnI (Q4, median 7.3 ng/L) had a greater risk of developing LLD-related events (adjusted HR: 1.88, 95% CI: 1.22 to 2.91), hospitalisation (adjusted HR: 1.65, 95% CI: 1.04 to 2.64) and death (adjusted HR: 2.27, 95% CI: 1.13 to 4.59), after adjusting for established cardiovascular and dementia risk factors, including apolipoprotein E (APOE) genotype. Conclusion: Among older women, hs-cTnI levels below the sex-specific 99th percentile for myocardial injury were associated with an increased risk of LLD events over 14.5 years. These findings suggest that hs-cTnI may identify older women at higher risk of LLD, capturing both cardiovascular and brain health vulnerability in older age.

Go to article

Establishment Of Reference Intervals For Serum Immunoglobulin G N-Glycosylation Features In Healthy Chinese Adults: A Nationwide Survey In The Framework Of Predictive, Preventive, And Personalized Medicine, Changyu Liu, Yinghao Wang, Xingang Li, Xiaojia Xu, Ruirui Xu, Cuihong Tian, Zhixian Chen, Xinxia Lu, Yuejin Li, Meng Wang, Zhaoyang Tang, Xueyu Chen, Guoyong Ding, Xuerui Tan, Dong Li, Haifeng Hou, Wei Wang Jan 2025

Establishment Of Reference Intervals For Serum Immunoglobulin G N-Glycosylation Features In Healthy Chinese Adults: A Nationwide Survey In The Framework Of Predictive, Preventive, And Personalized Medicine, Changyu Liu, Yinghao Wang, Xingang Li, Xiaojia Xu, Ruirui Xu, Cuihong Tian, Zhixian Chen, Xinxia Lu, Yuejin Li, Meng Wang, Zhaoyang Tang, Xueyu Chen, Guoyong Ding, Xuerui Tan, Dong Li, Haifeng Hou, Wei Wang

Research outputs 2022 to 2026

Background: Immunoglobulin G (IgG) N-glycosylation plays a vital role in the pathogenesis of autoimmune disorders, inflammatory diseases, and viral infections. While various models of serum IgG N-glycosylation have been developed to identify individuals at high risk for relevant diseases, reference intervals (RIs) for the levels of IgG N-glycans have not been established yet. Identifying RIs for serum IgG N-glycans closely associated with biological aging and disease risk contributes to predictive, preventive, and personalized medicine (PPPM/3PM), which results in improvement of patients’ outcomes, enhancement of healthcare efficiency, and in reducing burden of chronic diseases. This study is aimed at defining the …

Go to article

Tetrazole-Containing Naphthalene Bis-Sulfonamide Keap1-Nrf2 Interaction Inhibitors With Unexpected Binding Modes, Nikolaos D Georgakopoulos, Sandeep K Talapatra, Sharadha Dayalan Naidu, Dina Dikovskaya, Maureen Higgins, Jemma Gatliff, Roxani Nikoloudaki, Marjolein Schaap, Jasmine M Walker, Christopher Wardby, Albena T Dinkova-Kostova, Sarah Harris, Frank Kozielski, Geoff Wells Jan 2025

Tetrazole-Containing Naphthalene Bis-Sulfonamide Keap1-Nrf2 Interaction Inhibitors With Unexpected Binding Modes, Nikolaos D Georgakopoulos, Sandeep K Talapatra, Sharadha Dayalan Naidu, Dina Dikovskaya, Maureen Higgins, Jemma Gatliff, Roxani Nikoloudaki, Marjolein Schaap, Jasmine M Walker, Christopher Wardby, Albena T Dinkova-Kostova, Sarah Harris, Frank Kozielski, Geoff Wells

Peninsula Medical School

Naphthalene bis-sulfonamides are amongst the most studied inhibitors of the interaction between Kelch-like ECH-associated protein-1 (Keap1), a ubiquitination facilitator protein and the nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor associated with diverse cytoprotective responses. The compounds bind to the C-terminal Kelch domain of Keap1 and occupy the Nrf2 binding pocket, causing Nrf2 to accumulate and increase the expression of a battery of antioxidant response element genes. The binding modes of the compounds have been characterised through a series of X-ray crystallography and binding assay studies. In this work we have evaluated a series of symmetric and asymmetric …

Go to article

First Prev