Digital Commons Network^™

Toward A Roadmap For Addressing Today's Health Dilemma-The 101-Statement Consensus Report, Katharina C. Wirnitzer, Mohamad Motevalli, Derrick R. Tanous, Clemens Drenowatz, Maximilian Moser, Holger Cramer, Thomas Rosemann, Karl-Heinz Wagner, Andreas Michalsen, Beat Knechtle, Zlatko Fras, Merel Ritskes-Hoitinga, Adilson Marques, Natasa Fidler Mis, Fatima C. Stanford, Christian Schubert, Nandu Goswami, Claus Leitzmann, Per Morten Fredriksen, Gerhard Ruedl, Doris Wilflingseder, Rodrigo A. Lima, Christian Kessler, Michael Jeitler, Naim A. Khan, Hassan Joulaei, Maryam Fatemi, Andrew Knight, Karl W. Kratky, Kara K. Palmer

School of Health Professions

Importance: In recent decades there has been an expansion in the quantity and quality of scientific findings and guidelines on different health topics to promote individual and public health status. Reports also indicate that there has been a simultaneous increase in the financial burden of disease, including trillions spent on healthcare resources by governments worldwide (predominantly in developing countries) to address health concerns. At the same time, personal health behavior is well-known as efficient and cost-free, holding four times the potential to prevent early death compared to health care. Despite this knowledge, data show that the increasing prevalence of unhealthy …

Functional Classification Of Platelet Gene Variants Using Crispr Hdr In Cd34+ Cell-Derived Megakaryocytes, Yasuhiro Kosaka, Brandon Lopez, Nina Kishimoto, Shancy Jacob, Emilie Montenont, Rodrigo Huallanca, Graeson Coughenour, Jorge Di Paola, Justyne Ross, Kristy Lee, Matthew T Rondina, Paul F Bray, Jesse W Rowley

2020-Current year OA Pubs

The interpretation of genetic variants in inherited diseases, such as inherited platelet disorders (IPDs), remains a major clinical challenge, as most are classified as variants of uncertain significance (VUSs). A key barrier to functional evaluation is the lack of accessible, lineage-appropriate assays that reliably reflect native gene regulation and cell-specific biology. To address this gap, we developed CRIMSON HD (CRISPR-edited megakaryocytes [MKs] for surveying platelet variant functions through homology-directed repair [HDR]), a CRISPR-Cas9 HDR-based genome-editing platform applicable to CD34

Discovery Of A Small Molecule Tlr3 Agonist Adjuvant, Branden Lee, Danica Dong, Etsuro Nanishi, John Mark Awad, Kimia Abedi, Yoshine Saito, Francesco Borriello, Soumik Barman, Byron Brook, Aisling Kelly, Manisha Menon, Constance Marques-Mourlet, Maansi Gupta, Ida Lister, Chiwoo Oh, Kevin Lyskawa, Morgan Goetz, Kristina Walker, Wing Ki Cheng, Spencer Brightman, Pankaj Sharma, Timothy O'Meara, Katherine Chew, Daniel Vieira, Kevin Ryff, Cali Sweitzer, Sanya Thomas, Simon Van Haren, Matthew Pettengill, Hyuk-Soo Seo, Sirano Dhe-Paganon, Wei Zhang, Ofer Levy, David Dowling

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Pattern-recognition receptor (PRR) agonists are valuable agents across multiple medical applications, from vaccinology to immune-oncology. However, well-defined and potent small molecule agonists for many PRRs still await discovery and development. Screening of chemical libraries of ~200,000 small molecules for maturation of human monocytic cells by quantifying NF-κB activation and cell adherence was completed. From this screen, we selected a thiazole benzamide derivative, PVP-057, for its robust immunomodulatory properties, low toxicity profile, and concentration-dependent activity. In vitro investigation of pathway and receptor activation reveals that PVP-057 is a Toll-like receptor 3 (TLR3) agonist. As a single-component adjuvant, administered intramuscularly or intradermally …

Comparing Isocitrate Dehydrogenase Inhibitors With Procarbazine, Lomustine, And Vincristine Chemotherapy For Oligodendrogliomas, Gerardo Duran, Diego Pichardo-Rojas, Ahmed Hashim Ali, Peter Passias, Angela Downes, Wilson Z Ray, Gregory J Zipfel, Hakeem J Shakir, Andrew Bauer, Andrew Jea, Ian F Dunn, Jeffrey A Zuccato, Christopher S Graffeo, M Burhan Janjua

2020-Current year OA Pubs

The abstract has been submitted for presentation to the AANS 2026 meeting being held in San Antonio, TX, USA.

Brain Metabolic-Functional (De)Coupling From Health To Glioma Dysfunction, G Vallini, G Baron, E Silvestri, T Volpi, A G Vlassenko, M S Goyal, A Chiuso, D Cecchin, M Corbetta, A Bertoldo

2020-Current year OA Pubs

The interplay between brain metabolism and function supports the brain's adaptive capacity in cognitively demanding processes. Prior work has linked glucose metabolism to resting-state fMRI activity, but often overlooks both hemodynamic confounders in the BOLD signal and the brain's dynamic nature. To address this, we employed a novel effective connectivity decomposition, separating symmetric partial covariance, capturing "true" statistical dependencies between regions, from antisymmetric differential covariance, reflecting directional brain flow. In 42 healthy subjects, we show that partial covariance corresponds to metabolic connectivity across regions, while node directionality relates to standardized uptake value ratio, a proxy for local glucose consumption. We …

2017 Rocky Mountain National Park Research Conference, United States Department Of Interior

Rocky Mountain National Park

The work highlighted by this conference addresses key issues, including climate change, the spread of exotic plants, large scale restoration needs, environmental contaminants and disease, a need for greater relevancy to youth, and inadequate capacity to keep pace with growing visitation. The NPS Director's Order "Resource Stewardship for the 21st Century" directs park managers to steward resources for continuous change that is not yet fully understood. This challenge makes research, learning, and engagement at local to global scales more important than ever. The magnitude of issues and opportunities currently facing park managers is reflected in the breadth and depth of …

Rapid Ascent: Rocky Mountain National Park In The Great Acceleration: 1945-Present, Max Boxwell

Rocky Mountain National Park

A Master's Thesis asserting that wat-time technologies cheap fossil fuels, and a culture of techno-optimism—epitomized by the Mission 66 development program—helped foster a “Great Acceleration” of human alterations of Earth’s natural systems.

Abbey, Edward; Beau, Lucas; Braudel, Fernand; Carhart, Arthur; Collins, Kay; Condon, David; Contor, Robert; Crutzen, Paul; Fry, John; Guse, Neal; Hirt, Paul; Hughes, George; Keizer, Garret; Knous, Robert; Love, John Arthur; Menning, Edgar; Mills, Enos; Mooney, David; Noland, Jerry; Olson, Sigurd; Philpott, William; Redman, Mayme; Stoemer, Eugene; Sutter, Paul; Wirth, Conrad; Zalasiewicz, Jan; Leopold, Aldo; Rocky Mountain National Park; Rocky Mountains; Great Acceleration; Anthropocene; Spindletop; Tennessee Valley Authority; …

Rocky Mountain National Park's Loch Vale Watershed, Jill Barron

Rocky Mountain National Park

A News Account of the National Park Service investigation whether there is an acidic deposition problem, and how acidic deposition affects high elevation ecosystems of the Southern Rocky Mountains.

Shared Space, Contested Space: Enslaved Women In The Contested Space Ofwhite Texas Baptists, 1840-1860, David Wilkie

Journal of Texas History

No abstract provided.

Cardiovascular Disease And Pregnancy: Clinical Outcomes From A Tertiary Center Experience In Saudi Arabia, Nouf Alanazi, Sara Abou Al-Saud, Wareef Almousa, Ghada Alshalan, Jumana Alqahtani, Munira Alsharif, Abrar Alshahrani, Hessah Alothman

Journal of the Saudi Heart Association

Cardiovascular disease complicates pregnancy and elevates maternal and fetal risks. Local data in Saudi Arabia is scarce. This study examines pregnancy outcomes in women with cardiovascular disease at a tertiary center. A retrospective cohort study of 103 cardio-obstetric patients (2015-2023) at King Khalid University Hospital. Multivariable logistic regression identified risk factors for adverse maternal and neonatal outcomes, with significance at p

Physicochemical And Biological Evaluation Of Aque-Duct Water In Kosovo, Demokrat Nuha, Arbër Bytyçi, Fisnik Laha, Pajtim Bytyçi, Osman Fetoshi

International Journal of Business and Technology

The study analyzes the water quality of aqueducts in Drenas, Prishtina, Lipjan, and Shtime, Kosovo, in June and August 2024. The parameters assessed include physicochemical properties like color, turbidity, pH, free chlorine, chlorides, conductivity, and metal ions (Fe²⁺, Mn²⁺, Al), alongside biological indicators such as coliform bacteria. The results indicate that most parameters are within acceptable limits, reflecting overall good water quality. However, variations were noted: Prishtina's low chlorine levels may pose microbial risks, and the increased chlorides and conductivity in Lipjan suggest the impact of urban runoff or industrial activities. Seasonal shifts, especially during August, influenced the concentration of …

Determination Of General Parameters, Total Phenols And Total Flavonoids Content For The Assessment Of The General Quality Of Herbs From The Two Sideritis Species (S. Scardica And S. Raeseri), Bujar Qazimi, Shpend Dragusha, Hyrije Koraqi, Gentiana Balaj, Vesel Qazimi

International Journal of Business and Technology

The determination of general parameters (loss on drying test, total ash, and ash insoluble in dilute HCl) as well as the determination of total phenols content (TPC) and total flavonoids content (TFC) were determined in the aerial part of Sideritis scardica and S. raeseri collected in different localities in North Macedonia and Albania. In the analyzed samples of S. scardica and S. raeseri loss by drying was 6.65-8.01% and 7.08-8.42%, the content of total ash was 4.91-7.41% and 4.72-7.74%, while the content of total ash insoluble in diluted HCl was 0.13-0.27% and 0.05-0.75%, respectively. The amounts of phenolics content and …

The Picotesla Protocol: Energy-Matched Neuromorphic Brain–Ai Interface With Quantum-Responsive Event, Samuel Church

Defensive Publications Series

This disclosure presents a brain–AI interface architecture that operates under a strict sub-50 W system power envelope to reduce electromagnetic and thermal noise to near-brain levels, enabling event-driven coupling between biological neural surprise events and a neuromorphic spiking system. The system comprises: (i) a brain signal receiver (EEG) with alpha/theta-band feature extraction; (ii) an optional quantum-responsive transducer (e.g., NV-center magnetometer or QRNG correlator) for timing-level sensitivity to picotesla-scale field perturbations; and (iii) an energy-matched neuromorphic processor (e.g., Loihi-class SNN or low-power NPU) that converts biological “surprise” events into discrete spikes with < 40 μs latency and learns via STDP. The disclosure includes enabling details: system diagrams, energy budgets, filtering equations, spike-encoding logic, and experimental protocols (including physically isolated, Faraday-caged conditions) to ensure that the design is reproducible and citable as prior art. This publication is intended as a defensive disclosure to dedicate these concepts to the public domain and prevent later patenting of substantially similar systems

The Hidden Cost Of Metformin: Deficiency Of Vitamin B12 In Iraqi Patients With Type 2 Diabetes, Noor Mohammed Obaid, Halla Talib Salih, Mohammed Abdulzahra Hussein, Yousif M. I Al-Mohammed Amin, Mustafa Raheem Oglah

Maaen Journal for Medical Sciences

Background: Metformin remains a cornerstone in the management of type 2 diabetes mellitus. However, extended use has been increasingly linked to vitamin B12 deficiency, contributing to neuropathy, anemia, and cognitive impairment.

Objective: To assess the prevalence of vitamin B12 deficiency among Iraqi patients with type 2 diabetes mellitus receiving long-term metformin therapy and to identify associated clinical and demographic risk factors.

Methods: This cross-sectional study enrolled 500 type 2 diabetes mellitus patients on metformin for ≥18 months. Serum vitamin B12 levels were measured using chemiluminescence immunoassay. Correlations with demographic and clinical variables (including smoking, hemoglobin, and fasting blood sugar were …

Serum Ccr7 As A Diagnostic Biomarker In Acute And Chronic Pyelonephritis In Iraq, Dhafer Rahman Abed Al-Janabi, Ahmed Abduljabbar Jaloob Aljanaby

NJF Biomedicine Journal

Background: Pyelonephritis is a serious kidney infection primarily caused by E. coli. This study evaluated serum CCR7 levels in patients with acute and chronic pyelonephritis.

Objectives: To assess serum CCR7 concentrations and determine its potential as a diagnostic biomarker.

Methods: A cross-sectional study included 30 acute, 30 chronic pyelonephritis patients, and 29 healthy controls. Serum CCR7 was measured using ELISA and analyzed by one-way ANOVA.

Results: CCR7 levels were significantly higher in pyelonephritis patients compared to controls (P < 0.05). Chronic cases showed higher CCR7 levels than acute cases, but the difference was not statistically significant.

Conclusion: Elevated CCR7 is associated with pyelonephritis and may serve as a supplementary diagnostic biomarker. Further studies are required …

Impact Of Various Laboratory Techniques Upon Accuracy Of Hemoglobin Measurement, Ali Saleem Abdulridha Aridhee

NJF Biomedicine Journal

Introduction: Hemoglobin is one of the most important biological substances in the body, as it is the primary carrier of oxygen to the body's cells. Without this essential element, cells cannot receive oxygen, nor can they remove carbon dioxide. Hemoglobin has many types, one of which is normal, and many diseases are related to the synthesis and types of hemoglobin. These diseases are called anemia, and there are many types of anemia depending on the abnormal type of hemoglobin. The ideal way to diagnose such diseases is by measuring the hemoglobin concentration in the blood. Over the past decades, various …

Serum Ccr7 As A Diagnostic Marker In Acute And Chronic Pyelonephritis: Findings From A Cross-Sectional Study In Iraq, Dhafer Rahman Abed Al-Janabi, Ahmed Abduljabbar Jaloob Aljanaby

NJF Biomedicine Journal

Background: Pyelonephritis is a serious kidney infection primarily caused by Gram-negative bacteria, notably Escherichia coli. Understanding the host immune response is essential for developing diagnostic tools. This study aimed to evaluate the serum levels of CC-chemokine receptor 7 (CCR7) in patients with acute and chronic pyelonephritis. Objectives: To assess serum CCR7 concentrations in patients with acute and chronic pyelonephritis, compare them to healthy controls, and determine the potential of CCR7 as a diagnostic biomarker. Materials and Methods: This cross-sectional study was conducted in Najaf, Iraq, involving 89 participants: 30 with acute pyelonephritis, 30 with chronic pyelonephritis, and 29 healthy …

Applications Of Nanoparticle Systems In Drug Delivery Technology, Sadeq R. Atiyah, Samer Ali Hasan, Ali Jaaen Seger, Mohamed A. Akl

NJF Biomedicine Journal

The nanoparticle-based drug delivery system (DDS) is thought to be a viable cancer treatment method. Nanoparticle-based DDS outperforms standard DDS in terms of drug and protein half-life, hydrophobic drug solubility, and overall efficacy. providing for regulated and targeted medicine release at the sick location. The nexus of nanotechnology and medicine gave rise to the relatively new area of nanomedicine. Its basis is the medical manipulation of materials at the nanoscale. In certain situations, drugs with a superior safety profile—like chemotherapeutic cancer treatments, which carry a significant toxicity risk—can be delivered by nanotechnology. The fact that living cells are tiny virtual …

Daily Eastern News: December 03, 2025, Eastern Illinois University

Daily Eastern News: 2025-2026

No abstract provided.

Genomic Annotation And Biological Characterization Of Three Novel Gordonia Rubripertincta Bacteriophages, Sri Rishitha Nannapaneni

All HCAS Student Capstones, Theses, and Dissertations

Antimicrobial resistance (AMR) is a global crisis, with 1 in 6 bacterial infections being resistant to antibiotics and causing 40 million deaths between 1990 and 2021 worldwide. This threat has resulted in the demand for alternative therapies, like bacteriophage therapy which uses viruses to treat bacterial infections by killing them. Gordonia rubripertincta is a gram-positive bacterium that is found in various habitats: water, soil, and on the exterior of plants. Gordonia species are rare, however, they are emerging as opportunistic human pathogens that may cause various infections in any individual. G. rubripertincta infections occur from surgical complications with a catheter …

Fall 2025 Student Scholar Symposium Abstract Volume, Chapman University Center For Undergraduate Excellence

Student Scholar Symposium Abstracts and Posters

No abstract provided.

Imaging Of Dynamic Processes In Materials With A Laser-Wakefield Accelerator, J. Kang, R. J. Shalloo, M. J. Higgins, S. J.D. Dann, J. N. Gruse, C. I.D. Underwood, A. F. Antoine, C. Arran, C. D. Baird, M. D. Balcazar, N. Bourgeois, J. A. Cardarelli, K. Krushelnick, S. P.D. Mangles, C. D. Murphy, N. Lu, P. P. Rajeev, M. P. Selwood, D. R. Symes, C. P. Ridgers, A. G.R. Thomas, C. Thornton, Z. Najmudin, P. G. Sanders, P. D. Staublin, A. J. Shahani, M. J.V. Streeter

Michigan Tech Publications

Betatron x rays generated from laser-wakefield accelerators are a promising source for imaging dynamic processes in materials. Here, we present proof-of-concept imaging of microstructural evolution in a hypermonotectic Al-Bi alloy, which consists of liquid Bi particles in a solid Al matrix. The images capture the elongation and fragmentation of Bi particles upon isothermal annealing. Because of the femtosecond time scale of the betatron source, the images are not subject to motion blur, whereas the accessibility of the source allows for studies of long-term processes such as annealing. The high-resolution data reveal that the evolution of Bi particles is mediated by …

Emerging Tools In Plant Genome Editing, Shilpi Sharma, Naveen Kumar Saroha, Abhilasha Sehrawat, Guiliang Tang, Deepali Singh, Sachin Teotia

Michigan Tech Publications

Plant genome editing has undergone a transformative shift with the advent of advanced molecular tools, offering unprecedented levels of precision, flexibility and efficiency in modifying genetic material. While classical site-directed nucleases such as ZFNs, TALENs and CRISPR-Cas9 have revolutionized genome engineering by enabling targeted mutagenesis and gene knockouts, the landscape is now rapidly evolving with the emergence of novel systems that go beyond the conventional double strand break (DSB)-mediated approaches. Advanced and recent tools include LEAPER, SATI, RESTORE, RESCUE, ARCUT, SPARDA, helicase-based approaches like HACE and Type IV-A CRISPR system, and transposon-based techniques like TATSI and piggyBac. These tools unlock …

December 3, 2025 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Trends In Cardiovascular Disease Prevalence Among Adults With Type 1 Diabetes In The Usa, Orighomisan Freda Agboghoroma, Kory R. Heier, Omer Atac, Meredith S. Duncan, Anna Kucharska-Newton, Mary E. Lacy

Epidemiology and Environmental Health Faculty Publications

Introduction Cardiovascular disease (CVD) is a common complication and major cause of mortality in people with type 1 diabetes (T1D). This study quantifies the prevalence of CVD among commercially insured adults with T1D in the USA from 2017 to 2021, overall and among age-defined and sex-defined subgroups. Research design and methods We used Merative MarketScan nationwide commercial insurance claims database (2017–2021) to identify adults ≥20 years with T1D (International Classification of Diseases, 10th Revision (ICD-10) codes). CVD ascertainment was based on ICD-10 codes for myocardial infarction, atrial fibrillation, ischemic heart disease, heart failure, peripheral artery disease, and stroke. Comorbidities included …

2025-12-03 [Review] Lions And Tigers And Plot Holes, Oh My!: A ‘Wicked: For Good’ Review, Julia Pilch

The Spectator Online

No abstract provided.

Selenium Nanoparticles As Versatile Delivery Tools, Amir Nasrolahi Shirazi, Rajesh Vadlapatla, Ajoy Koomer, Kyle Yep, Keykavous Parang

Pharmacy Faculty Articles and Research

Selenium nanoparticles (SeNPs) have emerged as promising metal-based nanoparticles for drug delivery due to their unique physicochemical properties, intrinsic bioactivity, and biocompatibility. SeNPs offer a lower toxicity, higher bioavailability, and flexibility to be customized for surface chemistry compared to traditional selenium compounds. Advances in synthetic strategies, including chemical reduction, green biosynthesis, and surface functionalization with polymers, peptides, or ligands, have improved their stability, targeting capability, and circulation time. SeNP-based systems have demonstrated unique anticancer, antimicrobial, and anti-inflammatory activities, as they can function as drug carriers and active therapeutic agents. The surface of SeNPs has been functionalized with ligands such as …

Decoding The Chameleon Game, Tri Dang '25, Hieu Tran, Brian T. Howard, Sutthirut Charoenphon, Dat Nguyen '25

Student Research

The Chameleon game is a challenging word association activity where players are given a secret word and must respond with words relevant to that secret word. It requires strategic thinking and deduction. The Chameleon must cleverly guess the secret keyword in this game while avoiding suspicion. Our research aims to create an advanced artificial intelligence (AI) model that can play the Chameleon game from both perspectives: as the Chameleon and as a Human. This AI is designed to guess secret keywords based on the information provided by the players, choose the best strategies to avoid detection as the Chameleon, identify …

"Learning A New Me", Rebecca Trent-Burt

INRW/Coreq Student Showcase

Fall 2025 Student Showcase

Unsaturated Fatty Acid Oil-Based Microdroplets: A Promising Novel Class Of Microdroplets, Ramiz S. Alejilat

Seton Hall University Dissertations and Theses (ETDs)

Droplet-based microfluidics has rapidly advanced numerous fields, including chemistry, biology, materials science, medicine, food science, and cosmetics. In these systems, fluorocarbon oil combined with fluorinated surfactants is the preferred medium for fluid encapsulation, offering exceptional stability and biocompatibility essential for sensitive biological and chemical processes. However, growing concerns about the environmental and biological risks associated with fluorinated chemicals have prompted a search for alternatives.

This study is the first to explore the use of unsaturated fatty acids derived from emu oil for microdroplet formation. We characterized droplet formation based on flow rates and the presence non-fluorinated surfactant at a certain …