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Full-Text Articles in Entire DC Network
A Quantitative Study Exploring The Relationship Between Adverse Childhood Experiences And Fibromyalgia Symptoms And The Moderating Role Of Attachment To God, Darlene M. Scott
A Quantitative Study Exploring The Relationship Between Adverse Childhood Experiences And Fibromyalgia Symptoms And The Moderating Role Of Attachment To God, Darlene M. Scott
Doctoral Dissertations and Projects
Fibromyalgia, also known as Fibromyalgia Syndrome (FMS), is a condition that causes widespread musculoskeletal pain throughout the body, insomnia, tenderness and inflammation at specific pressure points on the body. This research aimed to explore the relationship between Adverse Childhood Experiences (ACEs) and FMS symptom severity. In addition, this study examined if attachment to God is a moderator of the relationship between ACEs and FMS symptoms, and if adults with four or more ACEs have higher levels of FMS symptoms than those with three or fewer ACEs. The sample consists of 99 (n = 99) participants diagnosed with FMS recruited online. …
A Predictive Correlational Study Of The Relationship Between Faculty Leadership Styles And Teacher Communication Orientation In Jamaica’S Higher Education System, Zandy Uriel Elliott
A Predictive Correlational Study Of The Relationship Between Faculty Leadership Styles And Teacher Communication Orientation In Jamaica’S Higher Education System, Zandy Uriel Elliott
Doctoral Dissertations and Projects
This quantitative study examined the extent to which faculty leadership styles, gender, and years of experience predict teacher communication orientation, specifically assertiveness (TCO-A) and responsiveness (TCO-R), among higher educational institutions in Jamaica. Grounded in communication theory and leadership frameworks, the study explored how faculty leadership express themselves and respond to others. Data were collected from 216 faculty members using the Multifactor Leadership Questionnaire (MLQ) and the Sociocommunicative Orientation Scale (SCO). Descriptive analyses indicated that participants’ mean responsiveness scores were slightly higher than assertiveness scores across all years-of-experience categories, with many displaying traits consistent with an “Amiable” to “Expressive” communication profile …
A Pilot Study Of Life Model Informed Therapy And Its Efficacy For Reducing Anxiety And Increasing Joy In Adults, William R. Mouer
A Pilot Study Of Life Model Informed Therapy And Its Efficacy For Reducing Anxiety And Increasing Joy In Adults, William R. Mouer
Doctoral Dissertations and Projects
This pilot study researched Life Model Informed Therapy (LMIT), a modality developed into a six-week treatment targeted to decrease anxiety and increase joy in adults that self-reported as having anxiety. Fourteen participants were recruited by Facebook ads in the Charlotte, North Carolina area. Outcome data were collected using the State Joy Scale (SJS) and Beck Anxiety Inventory (BAI). Participants received the same LMIT treatment for six consecutive, weekly, one-hour sessions. Participants self-reported on their joy and anxiety levels at three periods of time, including a pre-treatment, post-treatment and one month after-treatment test. Two one-way RM-ANOVA tests were conducted. Results of …
Exploring Secondary Educators’ Experiences Of Implementing Linguistic-Based Mathematics Instruction For English Language Learners: A Phenomenological Study, Adrian Pearce Martin
Exploring Secondary Educators’ Experiences Of Implementing Linguistic-Based Mathematics Instruction For English Language Learners: A Phenomenological Study, Adrian Pearce Martin
Doctoral Dissertations and Projects
The purpose of this phenomenological study was to describe the experiences of veteran educators with implementing linguistic-based instructional practices for English language learners (ELLs) in the secondary mathematics classroom. The theory guiding this study was Vygotsky’s sociocultural theory as it pertains to language and learning development through social exchanges with people, things, and events in a collective environment. This qualitative study took a hermeneutic, phenomenological approach which allowed the lived experiences of educators to be described, along with an interpretation of their instructional experiences with ELLs in the mathematics classroom to be made. The setting for this research was two …
The Divine Disciplinarian: God As The Model Father, Jacob Daniel Jones
The Divine Disciplinarian: God As The Model Father, Jacob Daniel Jones
Doctoral Dissertations and Projects
A pastor is responsible for instructing a congregation regarding biblical information and instruction. When a person is unsure of what the Bible teaches on a topic, the pastor can preach sermons and teach lessons that convey biblical truth. The growing congregation of Nevada Free Will Baptist Church consisted of believers who had been away from church for some time and new converts, resulting in a lack of biblical literacy due to their limited exposure to biblical truth. One area where congregants were uninformed was biblical parenting. This study addressed the problem of biblical illiteracy regarding parenting. It informed participants about …
The Lived Experiences Of Black Women Who Pastor Men In The Christian Methodist Episcopal Church, Karen En Bailey Garrison
The Lived Experiences Of Black Women Who Pastor Men In The Christian Methodist Episcopal Church, Karen En Bailey Garrison
Doctoral Dissertations and Projects
This qualitative phenomenological research project will explore the lived experiences of Black women pastoring at least three (3) who are not genetically related, weekly attending male congregants in the historically patriarchal culture of the Christian Methodist Episcopal (CME) Church with a minimum of at least one hundred (100) weekly attendees or more, and actively ordained. The CME Church has traditionally believed that the Bible prohibits women from serving as pastors or in any position of control over men. In four previous studies, Harden (2023), Morgan (2024), Tribble (2005), and Williams (2024) found that female pastors encountered obstacles throughout their journey …
Experiences Of Attachment And Childhood Sexual Abuse In Transgender Adults, Kimberly M. Langford
Experiences Of Attachment And Childhood Sexual Abuse In Transgender Adults, Kimberly M. Langford
Doctoral Dissertations and Projects
The purpose of this phenomenological study is to understand the experiences transgender adults have with attachment and childhood sexual abuse (CSA). The theory guiding this study is John Bowlby’s attachment theory, as secure attachment has the potential to act as a buffer against increased risks in cases where histories of CSA have occurred. Patterns of insecure and disorganized attachment are found at higher percentages within the transgender and gender dysphoric population than the cisgender population when a history of CSA is present. Research was needed to further explore and better understand the transgender population’s experiences of attachment and CSA with …
Examining The Relationship Between Trust-Based Relational Intervention® (Tbri®), Placement Stability, And The Voluntary Placement Disruption Of Minor Children In Substitute Caregiving Environments, Kelsey Tiernan-Coleman Harrison
Examining The Relationship Between Trust-Based Relational Intervention® (Tbri®), Placement Stability, And The Voluntary Placement Disruption Of Minor Children In Substitute Caregiving Environments, Kelsey Tiernan-Coleman Harrison
Doctoral Dissertations and Projects
Placement stability is associated with positive outcomes for minors in substitute caregiving environments. Numerous variables are related to placement stability, but there is a paucity of data highlighting specific interventions that improve placement stability. Trust-Based Relational Intervention (TBRI)® has been studied extensively in child welfare populations, with promising results, including improved caregiver-child attachment and decreased child internalizing and externalizing behavior, psychiatric symptomology, and caregiver burnout and stress. However, TBRI® has not been studied exclusively in relation to placement stability. This mixed-methods design study examined the relationship between TBRI®, including the degree and timing of exposure, placement stability, and voluntary placement …
Cognitive Behavioral Therapy: The Relationship Between Diet, Anxiety, And Depression And The Moderating Effect Of Cbt, Deborah J. Wright
Cognitive Behavioral Therapy: The Relationship Between Diet, Anxiety, And Depression And The Moderating Effect Of Cbt, Deborah J. Wright
Doctoral Dissertations and Projects
This study examined how cognitive behavioral therapy (CBT) techniques including cognitive restructuring and positive affirmations affect the relationship between dietary patterns and depression and anxiety symptoms. Research has established that CBT and diet affect depression and anxiety independently, but less research examines their collective impact. The study included 154 adult participants who filled out the Patient Health Questionnaire-9 and the Generalized Anxiety Disorder-7 alongside a Dietary Habits Checklist and a CBT Engagement Checklist during the previous two weeks. The results from multiple linear regressions showed no statistically significant moderation effects of CBT engagement on the relationship between diet and depression …
The Shared Experiences Of Betrayed Women In North Carolina Dealing With Long-Term Issues From Trauma Associated With Marital Infidelity: A Phenomenological Study, Anita M. Pittman
The Shared Experiences Of Betrayed Women In North Carolina Dealing With Long-Term Issues From Trauma Associated With Marital Infidelity: A Phenomenological Study, Anita M. Pittman
Doctoral Dissertations and Projects
The purpose of this qualitative phenomenological study was to describe the shared lived experiences of women affected by marital infidelity in North Carolina. Physical, emotional, and spiritual issues arise due to betrayal and brokenness of secure attachments. Findings from this study revealed that some shared emotional issues women faced following infidelity included depression, guilt, self-blame, and low self-esteem. Some issues took longer to recover from than others, such as loss of trust, low self-esteem, and varying physical health-related issues. The guiding theories for this study were Bowlby and Ainsworth’s Attachment Theory, Emotion-Focused Therapy developed by Greenberg and Johnson, and Vygotsky’s …
Music’S Transformative Power: A Phenomenological Exploration Of Christian Music’S Role In Enhancing Human Development, Crystal Ann Hubbell
Music’S Transformative Power: A Phenomenological Exploration Of Christian Music’S Role In Enhancing Human Development, Crystal Ann Hubbell
Doctoral Dissertations and Projects
Music is one of the most fundamental expressions of art, communication, and worship, linking to the conscience and personalities across cultures. Music provides a pathway to human emotions where music manifests as a therapeutic component for psychosomatic change. Furthermore, Christian music has not been explored as a therapeutic component for individuals struggling with mental health or cognitive challenges. The purpose of this study was to investigate how Christian music may serve as a therapeutic component of wellbeing in everyday lives of individuals. Using a transcendental phenomenological approach, this study investigated the lived experiences of 10 individuals who have experienced Christian …
The Lived Experiences Of Mothers Of Children With Down Syndrome Using Teleot Services: A Phenomenological Study, Tumini Umukoro
The Lived Experiences Of Mothers Of Children With Down Syndrome Using Teleot Services: A Phenomenological Study, Tumini Umukoro
Doctoral Dissertations and Projects
In response to the COVID-19 lockdown in the United States, therapy services for children with developmental delays transitioned to telehealth services. The purpose of this qualitative study was to explore the lived experiences of mothers of children diagnosed with Down syndrome (DS) who received occupational therapy services through telehealth (teleOT) using interpretative phenomenological analysis (IPA). Bronfenbrenner's ecological system theory was the framework used to address the research questions: RQ1: What are the lived experiences of mothers of children with DS regarding teleOT services? RQ2: How do mothers of children with DS perceive the benefits and challenges of telehealth OT services? …
A Concept Analysis Of Entrenched Toxic Cultures In Nursing Academia, Becky Good, Kristen Kirby, Karen J. Foli
A Concept Analysis Of Entrenched Toxic Cultures In Nursing Academia, Becky Good, Kristen Kirby, Karen J. Foli
Biennial Convention (CONV)
Introduction: Toxic cultures in nursing academia are environments characterized by incivility, bullying, and harassment, all concepts well defined in the literature (Beckmann et al., 2013; Clark, 2013; Fry & Schmer, 2021). While some toxic cultures can be addressed with targeted interventions, others are more widespread, established, and difficult to dismantle (Beitz & Beckmann, 2023; Clark & Ritter, 2018; Coates, 2024; Goldberg et al., 2013; Olsen et al., 2020). Specific data are scarce; however, as negative behaviors persist and intensify, we believe the unexplored phenomenon of entrenched toxic culture (ETC) emerges.
Purpose: This concept analysis aims to define ETCs in nursing …
Historical Review: More Than Two Decades Understanding The Genetic Architecture Of Hemostasis And Thrombosis, Maria Sabater-Lleal, Florian Thibord, Paul S De Vries, Jennifer Huffman, Alisa S Wolberg, Charles J Lowenstein, Alanna C Morrison, Andrew D Johnson, Nicholas L Smith
Historical Review: More Than Two Decades Understanding The Genetic Architecture Of Hemostasis And Thrombosis, Maria Sabater-Lleal, Florian Thibord, Paul S De Vries, Jennifer Huffman, Alisa S Wolberg, Charles J Lowenstein, Alanna C Morrison, Andrew D Johnson, Nicholas L Smith
Faculty, Staff and Student Publications
From the beginning of the millennium and the development of genome-wide analyses, the technical advances and remarkable increase in research sample sizes have led to an escalating number of discoveries revealing genetic determinants of levels of the main factors regulating hemostasis and thrombosis and demonstrating a clear polygenic complex regulation of most coagulation factors. These discoveries have been useful to understand the biology underlying hemostasis regulation and to understand risk of associated thrombotic disease, such as venous thromboembolism, coronary artery disease, and ischemic stroke. In this historical review, we outline the main discoveries in genetic studies of coagulation factors (fibrinogen …
Spartan Daily, December 4, 2025, San Jose State University, School Of Journalism And Mass Communications
Spartan Daily, December 4, 2025, San Jose State University, School Of Journalism And Mass Communications
Spartan Daily, 2025
Volume 165, Issue 42
Hsp90 Buffers Deleterious Genetic Variations In Brca1, Brant Gracia, Xing-Han Zhang, Patricia Montes, Tin Chanh Pham, Min Huang, Junjie Chen, Georgios Ioannis Karras
Hsp90 Buffers Deleterious Genetic Variations In Brca1, Brant Gracia, Xing-Han Zhang, Patricia Montes, Tin Chanh Pham, Min Huang, Junjie Chen, Georgios Ioannis Karras
Faculty, Staff and Student Publications
Protein-folding chaperone heat shock protein 90 (HSP90) buffers genetic variation in diverse organisms, but the clinical significance of HSP90 buffering in human disease remains unclear. Here, we show that HSP90 buffers mutations in the BRCT domain of BRCA1. HSP90-buffered BRCA1 mutations result in protein variants that retain interactions with partner proteins and strongly rely on HSP90 for protein stability and function in cell survival. Moreover, HSP90-buffered BRCA1 variants confer poly (ADP-ribose) polymerase (PARP) inhibitor resistance in cancer cells. Low-level HSP90 inhibition overcomes this resistance, revealing a cryptic and mutant-specific HSP90-contingent synthetic lethality. Furthermore, by stabilizing metastable variants across the entirety …
What My Church Mother Taught Me: A Phenomenological Exploration Of The Maternal Messages Given To Black Christian Women On How To Cope With Trauma, Melanie Joyce Coates
What My Church Mother Taught Me: A Phenomenological Exploration Of The Maternal Messages Given To Black Christian Women On How To Cope With Trauma, Melanie Joyce Coates
Doctoral Dissertations and Projects
The purpose of this qualitative phenomenological study was to explore the lived experiences of Black women in Churches of Christ as they perceive and interpret maternal messages about coping with and managing the effects of traumatic experiences. For this study, maternal messages was defined as advice, support, mentorship, or guidance from older Black Christian women to younger Black Christian women. It was important to understand the ways in which older Black women teach younger Black women in navigating mental health challenges within the context of a complex trauma history among African Americans. The first theory that guided this study was …
Academic Opportunities: A Phenomenological Study Of The Lived Experiences Of Principals That Foster Academic Achievement Of Students That Attend Secondary Title I Schools, Loretta O'Nita Speller
Academic Opportunities: A Phenomenological Study Of The Lived Experiences Of Principals That Foster Academic Achievement Of Students That Attend Secondary Title I Schools, Loretta O'Nita Speller
Doctoral Dissertations and Projects
The purpose of this transcendental phenomenological study is to explore the lived experiences of principals fostering the academic achievement of students in grades six through twelve who attend public secondary, Title I schools. The theory guiding this study was Maslow’s Hierarchy of needs. Maslow’s theory posits that if a person’s lower-level deficiency needs are not met, ascension to higher levels cannot happen. The central research question is: “What are the lived experiences of principals that lead secondary Title I schools and how do they foster academic achievement of their students?” Purposeful sampling was used in this study, and participants in …
Changing How Foster Care Begins: A Qualitative Study To Assess The Success Of One Specific Nonprofit, Madeline Ewoldt
Changing How Foster Care Begins: A Qualitative Study To Assess The Success Of One Specific Nonprofit, Madeline Ewoldt
Doctoral Dissertations and Projects
Most foster parents feel they do not receive adequate emotional support, funding, and preparation for their foster children in their care, which can lead to turnover, placement disruptions, and additional unnecessary caregiver changes for foster children. Attachment Theory explains children need consistent, warm, and loving caregiver relationships for healthy emotional, cognitive, and social development (Bowlby, 2018). For children in foster care, these relationships are already disrupted, therefore intervention for foster parent resiliency must be analyzed. The Bible calls Christians to care for the orphans, which leaves a large responsibility on Christians to care for those in foster care. There is …
Treatment Concerning Grief Disorder After Covid-19: Can Spiritual Care Help?, Tamika Marie Johnson
Treatment Concerning Grief Disorder After Covid-19: Can Spiritual Care Help?, Tamika Marie Johnson
Doctoral Dissertations and Projects
The phenomenological study described the experiences of spiritual care for adults who lost a loved one due to COVID-19 in Texas. The theory guiding the study was Viktor Frankl’s logotherapy, which was humanity’s search for meaning in a finite world governed by spiritual principles (García-Alandete, 2024; Parker, 2022; Seligman & Reichenberg, 2014). Grief was one of the occurrences that grappled with humanity’s understanding of life. Death was a universal phenomenon, and grief occurred as a response to a loss (Fernández & González-González, 2022). Research shows that symptoms of grief dissipate over time. When it was accompanied by prolonged time or …
A Causal-Comparative Study On The Impact Of Digital Learning Competency Professional Development And Socioeconomic Status On Teacher Digital Self-Efficacy, Sabrina C. Steigelman
A Causal-Comparative Study On The Impact Of Digital Learning Competency Professional Development And Socioeconomic Status On Teacher Digital Self-Efficacy, Sabrina C. Steigelman
Doctoral Dissertations and Projects
The purpose of this quantitative study was to examine the relationship between teacher self-efficacy, participation in digital learning professional development, and the socioeconomic status of schools. A causal-comparative design was used to investigate how these variables influenced teacher self-efficacy in implementing digital learning strategies aligned with the International Society for Technology in Education (ISTE) standards. The sample included K-12 educators from public schools across North Carolina, representing both low and mid- socioeconomic school settings. Data were collected through a Qualtrics survey, which included the Technology Integration Confidence Scale Version 3 (TICS V.3) and a demographic questionnaire. A two-way ANOVA was …
A Hermeneutic Phenomenology Study: How Students Affected By Trauma Experience Transformative Learning Through Digital Tools, Anita Sarah Chen
A Hermeneutic Phenomenology Study: How Students Affected By Trauma Experience Transformative Learning Through Digital Tools, Anita Sarah Chen
Doctoral Dissertations and Projects
The purpose of this hermeneutical phenomenological study is to explore the lived experiences of adolescent students affected by trauma embarking on the transformative learning process as facilitated by digital learning tools. The theory used to guide the study will be the transformative learning theory by Jack Mezirow. The central research question is: How do students affected by trauma experience transformative learning through digital learning tools? Examining students affected by trauma undergoing the transformative learning process facilitated by digital learning tools will be explored using a hermeneutical qualitative design. Ten participants w selected through purposive sampling based on their experiences in …
Mirrors & Windows: A Phenomenological Study On Narrative Group Therapy With Adults Survivors Of Childhood Interpersonal Trauma, Bethany Walker
Mirrors & Windows: A Phenomenological Study On Narrative Group Therapy With Adults Survivors Of Childhood Interpersonal Trauma, Bethany Walker
Doctoral Dissertations and Projects
The purpose of this phenomenological study is to describe adult survivors of childhood interpersonal trauma's lived experiences with group narrative therapy in Texas. Three theories serve as the base for this study: Terr's childhood trauma theory, Vygotsky's social constructivism, and Fisher's narrative theory. Social constructivism informs the study by suggesting that group therapy fosters meaning making through shared narratives. Narrative theory informs this study with the concept participants of narrative group therapy can not only create, examine, and reauthor their stories but find connection with others and empowerment in sharing their stories. Participants in this study completed an interview and …
A Phenomenological Study Exploring The Common Themes Among Individuals Who Have Broken Generational Cycles Of Conflict Avoidance, Codependency, And People Pleasing, Joseph Daniel Mcginnis
A Phenomenological Study Exploring The Common Themes Among Individuals Who Have Broken Generational Cycles Of Conflict Avoidance, Codependency, And People Pleasing, Joseph Daniel Mcginnis
Doctoral Dissertations and Projects
Many healthy and unhealthy adult behaviors are transmitted from parent to child as generational behavior cycles. Conflict avoidance, codependency, and people-pleasing are all unhealthy relationship dynamics that are generationally passed down in such a way. Breaking these generational cycles of unhealthy relationship dynamics is often difficult. The goal of this phenomenological qualitative study was to explore the common themes among individuals who have broken the generational cycles of conflict avoidance, co-dependency, and people-pleasing. The study consisted of 17 participants who were identified as having broken the generational cycles of conflict avoidance, codependency, or people-pleasing. Each participant was either previously involved …
The Holy Spirit Fulfills The Great Commission By Affecting The Soul – The Conscience, Intellect, And Affections – Of Believers Through The Agency Of Discipleship, Farrah K. Stewart
The Holy Spirit Fulfills The Great Commission By Affecting The Soul – The Conscience, Intellect, And Affections – Of Believers Through The Agency Of Discipleship, Farrah K. Stewart
Doctoral Dissertations and Projects
Statement of Problem
A knowledge and awareness of the Holy Spirit tends to be the missing from the church today, although his power, presence, and role is not only needed, but is necessary to fulfill the last commandment given by Christ. Though silent, he and his work are – and should be – evident among, to, and through believers, both corporately and individually.
Research Question
What do the Great Commission passages in the Gospels and the book of Acts reveal about the mission of the Holy Spirit for the church today?
Thesis Statement
This dissertation argues that, according to the …
Investigating Technology Readiness In Blended Learning Environments For Secondary Education: A Case Study, Philipiah J. Antony
Investigating Technology Readiness In Blended Learning Environments For Secondary Education: A Case Study, Philipiah J. Antony
Doctoral Dissertations and Projects
The purpose of this case study was to discover how technological readiness affects the students’ mindset in blended learning environments for secondary school students at secondary schools in Trincomalee, Sri Lanka. The theories guiding this research are the Community of Inquiry (CoI) framework, as it states that blended learning environments connect the teaching and social communities, making a social fabric in which teaching and learning occur, and Bandura’s social cognitive theory, as it proposed students can construct knowledge by interacting with the learning environment lays the theoretical foundation for blended learning that focuses on building knowledge through a commitment to …
Investigating Personality Themes And Constructs Among Professional Horse Trainers, Jenny Norton Schamber
Investigating Personality Themes And Constructs Among Professional Horse Trainers, Jenny Norton Schamber
Doctoral Dissertations and Projects
The relationship between horses and humans has evolved and now horses are a part of therapy, leisure activities, competitions, and companionship with humans, and this evolution beckons further research into aspects that contribute to positivity in this relationship. This research examined the themes of personality among professional horse trainers by utilizing the Riso-Hudson Enneagram Type Indicator (RHETI), the Ten-Item Personality Inventory (TIPI), and semi-structured interviews. To be included in the study, participants needed to be at least 18 years of age, live in the United States, and receive at least half of their yearly income from training horses. There were …
Exploring The Relationship Between Loneliness And Real-Time Measurements Of Gsr And Hrv During Concept Mapping, And Cortisol And Oxytocin Levels, Jangwon Seo
Masters Theses
This study attempts to explore loneliness among college students from a bio-physio-psycho-social perspective, and it utilizes real-time physiological measurements (GSR and HRV) and biomarkers (cortisol and oxytocin) in conjunction with psychosocial assessments. The study employs both qualitative and quantitative methods, which involve concept mapping exercises, with the aim of comprehending the full nature of how loneliness interacts with physiological and psychological processes. At Time 1 (T1) we found significant positive correlations between loneliness and elevated GSR levels, which is indicative of increased sympathetic arousal (r = .35, p < .01). Additionally, there were significant negative correlations between loneliness and mean RR intervals in HRV that indicated autonomic dysregulation featured by increased sympathetic activities as well as reduced parasympathetic functions (r = -.28, p < .05). However, at Time 2 (T2), these correlations were not significant indicating possible temporal fluctuations due to adaptive responses or extraneous variables such social support systems or coping mechanisms. The qualitative data from concept mapping enriched the analysis by providing deeper insights into the cognitive and emotional processes underlying loneliness. Despite limitations like demographic skewness, funding constraints, logistical challenges, etc., this, therefore, highlights the need for multidimensional investigations of psychological phenomena. This has implications for future research as well as clinical practice, which could include using these integrative measures to develop holistic interventions for mental health disorders.
Kenyon Collegian - December 4, 2025
Grapes Cure Cancer: My First Molecular Docking Analysis Of Resveratrol Binding To Anti-Apoptotic Protein Bcl-2: In Silico, Sydni Ann Kolokoltsev, Vishwas Joshi
Grapes Cure Cancer: My First Molecular Docking Analysis Of Resveratrol Binding To Anti-Apoptotic Protein Bcl-2: In Silico, Sydni Ann Kolokoltsev, Vishwas Joshi
Publications and Research
B-cell lymphoma 2 (BCL-2) is an anti-apoptotic protein frequently overexpressed in cancer, enabling tumor cells to evade programmed death. Resveratrol, a grape-derived polyphenol, has reported anticancer properties. Here we performed in silico docking of resveratrol to human BCL-2 using AutoDock Vina. The best-ranked pose exhibited a predicted binding free energy of 8.0 kcal/mol and formed at least one short hydrogen bond (~1.8 Å) with pocket residues. These results support further evaluation of resveratrol as a potential modulator of BCL-2-mediated apoptosis.