Digital Commons Network^™

Childhood Asthma Biomarkers Derived From Plasma And Saliva Exosomal Mirnas, Abdelnaby Khalyfa, Mohit Verma, Meghan M. Alexander, Zhuanhong Qiao, Tammy Rood, Ragini Kapoor, Trupti Joshi, David Gozal, Benjamin D. Francisco

Biomedical Sciences

Asthma, the most common chronic respiratory condition in children, involves airway inflammation, hyper-responsiveness, and frequent exacerbation that worsen the airflow and inflammation. Exosomes, extracellular vesicles carrying microRNAs (miRNAs), play a key role in cell communication alongside other types of communication and are promising markers of asthma severity. This study compares exosomal miRNA and long non-coding RNA (lncRNA) profiles in boys with asthma, focusing on differences between those with normal lung functions and those with severe airflow obstruction. This study enrolled 20 boys aged 9–18 years with asthma, split into two groups based on their lung function. Ten had normal lung …

The Untapped Power Of Citizen Science: A Survey Of Utah Residents, Wesley Crump, Elizabeth Cohen, Shital Poudyal

Outcomes and Impact Quarterly

Citizen Science is an approach to involve the public in the scientific process to address locally relevant needs. A survey was conducted to explore Utahns’ relationship with citizen science. Results show a gap between respondents’ past participation and willingness to participate in citizen science, indicating an opportunity for USU Extension to strengthen its relationship with the public through citizen science.

Ai Questions; "The Ai Tea", Sally Brown

Artificial Intelligence Exhibit

This section includes a series of questions related to AI and the exhibit content, as well as button designs by WVU students and Art in the Libraries committee members, a list of the exhibition sponsors, and information on the exhibition launch panel.

Artificial Intelligence In Education, Sally Brown, Jill Woods, Mohamed Hefeida, Jennifer Sano-Franchini, Megan Vendemia, Erin Brock Carlson, Megan Leight, Gangqing Hu, Nicole Fuller

Artificial Intelligence Exhibit

This section explores the intersection of AI and education, including an overview of WVU's AI statement and submissions from WVU faculty, classes, students, and staff on AI related projects.

Advancing Circular Bioeconomy Through A Systems-Level Assessment Of Food Waste And Industrial Sludge Codigestion, Md Nizam Uddin, Cassidy Hartog, Emma Murray, Jacob Loveless, Luke Roberson, Asli Aslan, Francisco Cubas, Stetson Rowles

Civil Engineering & Construction: Faculty Publications

Disposal of food waste (FW) in landfills remains an unsustainable practice for organic waste management. Simultaneously, pulp and paper mills produce significant amounts of recalcitrant organic waste that is difficult to decompose due to its high lignocellulosic content. In this study, we developed an innovative approach to improve the digestion of pulp and paper mill sludge (PPMS) by amending FW to produce a low chemical oxygen demand (COD) sludge while recovering methane in the process. This codigestion process was evaluated through lab-scale biogas production experiments coupled with a comprehensive economic and environmental sustainability assessment. Biomethane production results revealed that the …

A Brief Guide To Statistical Analysis Of Grouped Data In Preclinical Research, Colby J Vorland, Lilian Golzarri-Arroyo, David B Allison

Children’s Nutrition Research Center Staff Publications

Clustering and nesting (C&N) arise in many preclinical studies such as when animals are group-housed, share litters, or in cell culture. Ignoring C&N undermines the validity of analyses. We explain how C&N arise and valid designs and analyses.

Book Review: How To Fight A War, Chase Metcalf

Parameters Bookshelf – Online Book Reviews

Author: Mike Martin

Reviewed by Colonel Chase Metcalf (US Army), assistant professor, Department of Military Strategy, Planning, and Operations, US Army War College

Current member of the British Parliament, former British Army officer with Afghanistan experience, and senior visiting research fellow at Kings College London’s War Studies Department Dr. Mike Martin delivers what he terms a “reference guide for the Commander in Chief” in How to Fight a War (3). The result is far more and will serve as an accessible primer for aspiring national security professionals and senior leaders seeking to understand the basic principles of employing violence to …

In Situ Thrust Measurement Of Fish During Locomotion; Test Case: Sharks, Braedon Payne, Bryan A. Keller, Daniel Weihs, Roi Gurka

Physics and Engineering Science

We present a novel method of measuring thrust of aquatic animals using in situ video data of swimming motions. To demonstrate its utility, the method was applied to several large elasmobranch species, which are typically highly challenging to measure. Using motion tracking software, we analyzed video footage of wild and captive sharks to track their instantaneous position and speed. In order to estimate the force output, we used the tail/body motion based on the swimming modes of the fish to calculate the water displaced by this motion during locomotion. Using Newton 3rd law, we have calculated the instantaneous force exerted …

Statistical Power To Detect Simultaneous Violation Of Proportionality In Hazards And Additive Assumption In Cox Regression Model, Lawrence Mensah Agbota

Theses and Dissertations

The Cox proportional hazards regression model is a widely employed semi-parametric tool in epidemiological and medical research for analyzing time-to-event data and assessing the relationship between patient survival times and one or more predictors. This method involves regression analyses necessitating a meticulous approach to careful examination of the covariates and the relationship among covariates included in the model through a series of critical decisions and steps. Violation of the additivity of the effects and the proportionality in hazards (PH) assumption can lead to biased results and misleading scientific findings. We conducted a Monte Carlo simulation study to assess the performance …

Hunter-Gatherer Subsistence Strategies In Changing Environments In Prehistoric Mindoro, Philippines, Alfred Ferdinand F. Pawlik

Sociology & Anthropology Department Faculty Publications

As an archipelago straddling two distinct biogeographic zones, Sunda and Wallacea, the Philippines have acted as a conduit for the movements of people, material culture and ideas across Southeast Asia throughout prehistory. The Mindoro Archaeology Project investigates several caves and rockshelters from the late Pleistocene and early Holocene, located in Sta. Teresa and Ilin Island in Occidental Mindoro on the southern end of Mindoro and explores the deep history of the first anatomically modern humans in the Philippines, the timeline of their arrival and dispersal, and their adaptation to coastal and island environments. By at least 40,000 years ago, anatomically …

Shsp Dean's Newsletter, Summer 2025, Robert W. Amler

SHSP Dean’s Newsletter

No abstract provided.

Gender Representation Of Composers In Recommended Wind Band Literature And Prominent Performances, Devon Alexis Gray Porter

USF Tampa Graduate Theses and Dissertations

The purpose of this research was to evaluate gender representation in recommended literature in wind band repertoire and prominent performances. I collected data from music lists approved by the National Band Association (NBA) state chapters, programs from the Midwest Clinic and College Band Directors National Association, music vendor catalogues, the Teaching Music Through Performance in Band series, and Florida Bandmasters Association (FBA) Music Performance Assessment (MPA) past performances. I evaluated names of composers to determine the male-female ratios and quantities for recommended works from these sources. I conducted further analysis to determine if trends existed in the relationships between composer …

Dean's Report- Summer-Fall 2025, Marina K. Holz

GSBMS Dean’s Report

No abstract provided.

Response Of Soybean To Variable Irrigation Levels In Eastern Nebraska Using The Aquacrop Model, Anmol Singh

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

AquaCrop was calibrated and validated for soybean [Glycine max (L.) Merr.] using 19 irrigation treatments from five years using data from field experiments. The model accurately simulated canopy cover (CC), soil water content (SWC), and grain yield, with overall validation nRMSE values of 12%, 7%, and 7%, respectively. The overall validation nRMSE for SWC in individual 30-cm soil layers was comparatively higher, at 19%. The model was subsequently applied for long-term simulations (2010–2024) to estimate soybean yield and water requirements for two dominant soil types, Yutan silty clay loam and Tomek silt loam under three irrigation levels - rainfed, …

Overcoming Maternal Antibody Interference In Swine Influenza: Advancing Dna Vaccine Strateies For Enhanced Immune Protection In Piglets, Danh Cong Lai

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Maternally derived antibodies (MDAs) play a vital role in protecting neonates from infectious diseases, but their presence at the time of vaccination can interfere with vaccine-induced immune responses, thereby reducing vaccine effectiveness. MDA interference has been documented in pigs vaccinated with whole inactivated virus (WIV) vaccines against swine influenza A virus (IAV). In this thesis, we evaluated the efficacy of a lipid nanoparticle encapsulated DNA (LNP-DNA) vaccine against swine IAV in the presence and absence of MDAs, comparing it to a WIV vaccine. In MDA-negative piglets, both the LNP-DNA and WIV vaccines induced strong immune responses and effectively prevented the …

Individualized Functional And Structural Language Lateralities In Temporal Lobe Epilepsy And Their Impact On Memory, Ankeeta Ankeeta, Qirui Zhang, Sam Sharifzadeh Javidi, Shilpi Modi, Michael R. Sperling, Joseph I. Tracy

Department of Neurology Faculty Papers

The basis and impact of functional asymmetries in the brain, particularly language lateralization, are not fully understood, and the relationship between functional and structural asymmetries remains largely untested. This study investigated the degree to which asymmetries in hemispheric language laterality are concordant with asymmetries in gray matter (GM) structure and whether the hemispheric organization of memory is influenced by functional language asymmetries. Structural and functional MR data was acquired from 261 individuals, including those with unilateral temporal lobe epilepsy (LTLE = 96, RTLE = 69) and matched with healthy participants (HPs = 96). Functional language laterality indices (LIs) were calculated …

Investigating Focal Adhesion Kinase Activation In Arteriovenous Fistula Maturation, Sam Fulkerson, Fuji Anday, Thi Hong Phuong Nguyen, Tatyana Isayeva-Waldrop, Steve Lim, Kevin Ingle, Timmy Lee

Expo Student Presentations

2025 Summer Expo Poster Presentation

• Biological & Life Sciences

Decoding Emt Heterogeneity In Pancreatic Cancer, John David Slowikowski, Julienne L. Carstens

Expo Student Presentations

2025 Summer Expo Poster Presentation

• Biological & Life Sciences
• Works in Progress

Measures Of Muscle Strength, Rate Of Force Development, And Fatiguability Across The Menstrual Cycle, Cassidy Wisler

All NMU Master's Theses

BACKGROUND: Hormone fluctuations and inconsistencies across the menstrual cycle paired with a shortage of literature on female physiology in exercise have made understanding on female exercise performance troublesome. Performance-based research has fallen behind and the increase in women participation and current evidence does not warrant general guidance on modulating specific exercise across the menstrual cycle. PURPOSE: The purpose of this study was to determine the effects of estrogen and progesterone on muscle strength, rate of force development, and fatiguability. METHODS: Nineteen recreationally active and eumenorrheic females (25.3 ± 5.8 yrs, 73.4 ± 12.2 kgs) volunteered to participate in the study. …

Investigating The Role Of Msbdnf – Trkb Signaling In The Maintenance Of Mitochondrial Populations Through The Bnip3 Mitophagy Pathway, Jack A. Horton

All NMU Master's Theses

Maintenance of mitochondrial transport and clearance at the pre- and post-synaptic terminal is an essential function of neuromuscular junctions to meet their high energy demands. Damaged or dysfunctional mitochondria can put stress on these synaptic junctions, ultimately leading to the degradation of the synapse and subsequent cell death. Dysfunctional mitochondria are also often present in neuromuscular diseases such as ALS. One possible mechanism by which neurons may eliminate dysfunctional mitochondria is through the muscle-synthesized BDNF (msBDNF) /TrkB-mediated Bcl-2 nineteen-kD interacting protein (BNIP3) mitophagy pathway, although the relationship is not well-defined. BNIP3 localizes to the mitochondria and triggers a loss of …

The Effect Of Skeletal Muscle-Synthesized Bdnf On Motor Neuron Soma Size And Bdnf Protein Abundance, Sydney Benson

All NMU Master's Theses

Brain derived neurotrophic factor (BDNF) is a neurotrophin essential to neuron health and maintenance in both the central nervous system and periphery. It acts as a positive feedback system for the body’s motor neurons and the muscles they innervate, strengthening the synapse between them. Skeletal muscle-synthesized BDNF transmission occurs across the neuromuscular junction, the site where motor neuron axons synapse with muscle fibers. BDNF transmission to tropomyosin receptor kinase B (TrkB) at the motor neuron axon terminal causes clathrin mediated endocytosis of the complex and an intracellular signaling cascade that recruits dynein motor proteins for retrograde transport of the BDNF/TrkB …

Elucidating The Role Of Mir-10a/B In The Wound Healing Process In Larval Zebrafish, Jacquelyn E. Jacobs

All NMU Master's Theses

This study explores the regulatory role of microRNA-10 (miR-10) in larval zebrafish caudal fin regeneration, a model with broad implications for the future of regenerative medicine. Building on prior research from the lab, which indicated that miR-10 knockdown impairs regeneration, we verified this finding through rescue experiments, assessed its influence on healing projections, and examined its role in the innate immune response during the wound healing process. To address these questions, we employed a multi-faceted approach, including timed matings, microinjections, immunohistochemistry, fixed sample microscopy, and live imaging. Our results show that the experimental introduction of exogenous miR-10 can rescue the …

Marigold Lodge: Family Home, Meeting Venue, And Community Landmark; Willard (Bill) Wichers: “Mr. Holland”, Sarah Lundy, Charlotte Ulloa

Archives and Special Collections Quarterly

Marigold Lodge: Family Home, Meeting Venue, and Community Landmark

Column: From the Director of Archives and Special Collections

Willard (Bill) Wichers: “Mr. Holland”

Mitigating Regression Faults Induced By Feature Evolution In Deep Learning Systems, Hanmo Yu, Zan Wang, Xuyang Chen, Junjie Chen, Jun Sun, Shuang Liu, Zishuo Dong

Research Collection School Of Computing and Information Systems

Deep learning (DL) systems have been widely utilized across various domains. However, the evolution of DL systems can result in regression faults. In addition to the evolution of DL systems through the incorporation of new data, feature evolution, such as the addition of new features, is also common and can introduce regression faults. In this work, we first investigate the underlying factors that are correlated with regression faults in feature evolution scenarios, i.e., redundancy and contribution shift. Based on our investigation, we propose a novel mitigation approach called FeaProtect, which aims to minimize the impact of these two factors. To …

The Indian Pharmacopoeia: Enabling Open Access And Crafting A ‘Sovereign Function Exception’ For Government Works, Aparajita Lath

National Law School Journal

Standardisation of drugs and access to such standards are important levers for effective drug regulation. The Indian Pharmacopoeia, the official book of standards for drugs in the country prescribed by the Union government under the Drugs and Cosmetics Act 1940, are legally binding and enforceable. Not only do the standards have the force of law but are also government-created. The Indian Pharmacopoeia Commission (IPC), a division of the Union Department of Health and Family Welfare, has a legal monopoly over creating and publishing this compendium. Though it is legally binding, the Indian Pharmacopoeia is neither in the public domain …

Histopathological Features Of Gastrointestinal And Pancreatic Neuroendocrine Neoplasms: An 11-Year Retrospective Study From A Tertiary Center In Saudi Arabia, Rana Y. Bokhary

Saudi Medical Journal

ABSTRACT Objectives: To evaluate the clinicopathological features of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) over 11 years at a single tertiary institution in Saudi Arabia. Methods: In a retrospective review, data from 71 patients diagnosed with GEP-NEN, at a tertiary academic center in Jeddah, Saudi Arabia, between January 2014 to December 2024, were analyzed for demographics, clinical presentation, tumor location, size, pathology, grade, and immunohistochemistry. The statistical analyses included Chi-square, Mann-Whitney-U, and Spearman’s correlation tests. Results: The cohort had a mean age of 54.9±15.1 years and comprised 62% males. Most tumors originated in the foregut (62.0%) and were unifocal (83.1%). Abdominal pain …

Identification Of Milk And Milk Product Adulteration By Molecular Methods, Isam Shaker Haza, Saad Sabah Fakhry

Al-Esraa University College Journal for Medical Sciences

The polyacrylamide gel electrophoresis sodium dodecylsulfate (SDS-PAGE) has been extensively used to separate native and denaturalized proteins. In various countries this has been useful to detect milk adulteration with whey, which is a fraud according to the current legal standards. The presence of glycomacropeptide (GMP) constitutes a marker of adulteration. It is released to the serum due to the hydrolysis of --casein peptide catalyzed by rennin incheese elaboration. In this work, the GMP detection was standardized as a pasteurized milk adulteration index, by means of GMP isolation with sequential precipitation in trichloroacetic acid at 24% and 50%, treatment with ethanol-ether …

Impact Of Hypocalcemia On Dickkopf-Related Protein 1 And Hmgb1 In Transfusion-Dependent Thalassemia Patients, Haneen Azeez Falih

Al-Esraa University College Journal for Medical Sciences

Background: Transfusion-dependent thalassemia (TDT) is associated with various symptoms including anaemia and bone problems. There is a need for more biomarkers of calcium disorders in TDT patients. In the present study, DKK 1 and HMGB1 are studied in TDT patients with hypocalcemia (TDT+Hypocalcemia) and normocalcemia (TDT+Normocalcemia) as a function of inflammation. Methods: TDT patients were classified according to the cut-off value (2.12 mM) of the adjusted serum calcium (Adj.T.Ca) into TDT+Normocalcemia (n = 54) and TDT+Hypocalcemia (n = 41) groups. Forty healthy controls have participated in the present study. DKK1 and HMGB1 were measured using the ELISA technique. Results: Both …

Electrocatalytic Degradation Of Methylene Blue Using Graphene Oxide, Antimony Oxide, And Graphene Oxide-Supported Antimony Oxide Ink-Based Electrodes, Maria Irene Myers Armas

Theses and Dissertations

This study investigates the electrocatalytic degradation of methylene blue (MB) using copper mesh electrodes coated with graphene oxide (GO), antimony oxide (Sb₂O₃), and their composite (GO/Sb₂O₃). These materials were evaluated across a pH range of 2 to 8 using sodium sulfate as the supporting electrolyte. UV-Vis spectroscopy at 665 nm confirmed dye degradation, with removal efficiencies reaching up to 95% at pH 2. However, degradation decreased at higher pH, with 40 – 60% removal at pH 8, depending on the electrode. Kinetic analyses revealed optimum performance under acidic conditions. GO/Sb₂O₃ electrodes demonstrated the most consistent and effective performance across all …

Investigating The Threshold Of Opa1-Mediated Mitochondrial Fusion In Shsy5y Cells, Jorge Alberto Elizondo

Theses and Dissertations

Mitochondrial dynamics occurring under stress-induced conditions in SHSY5Y neuroblastoma cells provide insight into the OPA1-mediated mitochondrial fusion threshold in cells of varying energetic demands. Mitochondria are dynamic structures that are continuously balancing fusion and fission, depending on cellular needs. The ability to fuse and divide relies on the maintenance of the mitochondrial transmembrane potential. Stress-induced conditions in SHSY5Y cells were induced via utilization of carbonyl cyanide m-chlorophenylhydrazone (CCCP), a protonophore that disrupts the transmembrane potential. OMA1 protein reacts to the loss of transmembrane potential and subsequently cleaves the fusion-active isoforms of OPA1, L-OPA1. This causes an accumulation of S-OPA1, the …