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2025

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Aeolus-Ds: Dust-Aware Ai Decision Support For Coccidioidomycosis (Valley Fever) — A Design Science Research Framework Integrating Aerosol Remote Sensing, Land Disturbance, And Clinical Sentinel Signals, Harsha Sammangi, Aditya Jagatha, Harshini Balaga Jul 2025

Aeolus-Ds: Dust-Aware Ai Decision Support For Coccidioidomycosis (Valley Fever) — A Design Science Research Framework Integrating Aerosol Remote Sensing, Land Disturbance, And Clinical Sentinel Signals, Harsha Sammangi, Aditya Jagatha, Harshini Balaga

Research & Publications

This paper presents Aeolus-DS, a design science research (DSR) artifact that integrates aerosol remote sensing (MAIAC AOD; dust fraction), mesoscale meteorology and soil moisture (ERA5), land-disturbance telemetry (construction, off-road vehicle activity, nightlights) and clinical sentinel signals (syndromic ED chief complaints, pneumonia rule-out) into a dust-aware, AI-driven early warning and decision-support system for Coccidioidomycosis (Valley Fever). Methodologically, we propose a graph spatiotemporal transformer with direction-aware attention and physics-guided regularisation reflecting aeolian transport. Using county-week panels (2014-2024) for the U.S. Southwest (AZ–CA–NV), Aeolus-DS improves now-casting mean absolute error (MAE) by 18% and two-week area under precision-recall curve (AUPRC) by 21% over …


2025-2026 Etsu General Academic Operating Budget (July), Budget And Financial Planning, East Tennessee State University Jul 2025

2025-2026 Etsu General Academic Operating Budget (July), Budget And Financial Planning, East Tennessee State University

ETSU General Academic Operating Budgets and Analysis

No abstract provided.


Building Social Butterflies And Learning Circles: The Key To Organizational Safety Potential, Trevor Farr Jul 2025

Building Social Butterflies And Learning Circles: The Key To Organizational Safety Potential, Trevor Farr

ASEM Capstones

2025 ASEM 620 Capstone Project


News From Hope College, Volume 57.1: Summer 2025, Hope College Jul 2025

News From Hope College, Volume 57.1: Summer 2025, Hope College

News from Hope College

No abstract provided.


​​Site Fidelity Is Associated With The Social Experience Of Forked Fungus Beetles (Bolitotherus Cornutus), Joo Yeon Kim , '22, C. W. Wood, E. D. Brodie Iii, Vincent A. Formica Jul 2025

​​Site Fidelity Is Associated With The Social Experience Of Forked Fungus Beetles (Bolitotherus Cornutus), Joo Yeon Kim , '22, C. W. Wood, E. D. Brodie Iii, Vincent A. Formica

Biology Faculty Works

Consistently returning to or remaining within a specific location, a behavior known as site fidelity, is a useful metric for quantifying animal space use. When multiple individuals display similar site fidelity patterns, they are likely to interact, shaping the degree and quality of their social interactions. However, the link between the expression of site fidelity behavior and an individual’s social experience has not been thoroughly investigated. In this study we examined (1) how intrinsic individual properties (body size and sex) predicted variation in site fidelity and (2) whether site fidelity was linked to the social experience of individuals in wild …


Gis-Based Swat Modeling For Surface Runoff Assessment To Support Urban Flood Resilience In Central Java, Indonesia, Putri Amalia Sholichah Ms., Endah Sulistyawati, Susana Paulina Dewi Jul 2025

Gis-Based Swat Modeling For Surface Runoff Assessment To Support Urban Flood Resilience In Central Java, Indonesia, Putri Amalia Sholichah Ms., Endah Sulistyawati, Susana Paulina Dewi

Smart City

Surface runoff significantly contributes to environmental hazards such as floods in Indonesia, including in Borobudur District. Based on watershed delineation, the administrative area of Borobudur District is predominantly located within the Sileng Subwatershed. The rehabilitation zones managed by PT Adaro Indonesia are located in several specific areas within this subwatershed. This study utilizes the SWAT (Soil and Water Assessment Tool) model integrated with GIS (Geographic Information System) to simulate surface runoff quantitaively in the Sileng subwatershed, part of the Progo watershed in Central Java Province. SWAT is applied in this research to simulate surface runoff in both watershed and …


Global Database For Naturally Occurring Radionuclides Associated With Offshore Oil And Gas Production, Ziran Wei, Songjie He, Stephanie Sharuga, Kanchan Maiti Jul 2025

Global Database For Naturally Occurring Radionuclides Associated With Offshore Oil And Gas Production, Ziran Wei, Songjie He, Stephanie Sharuga, Kanchan Maiti

Faculty Publications

This study compiles a comprehensive dataset on the occurrence, distribution, and potential impacts of Naturally Occurring Radionuclides (NORMs) near offshore oil and gas platforms. It encompasses data, including activities (Bq/l) and exposure levels (Msv), derived from various environmental matrices. A particular emphasis is placed on petroleum products and waste, such as produced water, scales, and sludges. The dataset contributes to a better understanding of the distribution of NORM wastes in marine environments, informs future radiological safety standards, contributes to the formulation of regulatory policies, and facilitates the design of mitigation strategies. The information—literature and data from five continents over the …


Water Exposure Time Distributions Controlled By Freshwater Releases In A Semi-Enclosed Estuary, Caitlin R.R. Turner, Matthew Hiatt Jul 2025

Water Exposure Time Distributions Controlled By Freshwater Releases In A Semi-Enclosed Estuary, Caitlin R.R. Turner, Matthew Hiatt

Faculty Publications

Freshwater diversions manage water shortages, salinity, and control floodwater by redirecting river flows; however, their full ecological and hydrological impact remains unknown. This study examines the Lake Pontchartrain Estuary in Louisiana using a hydrodynamic model and Lagrangian particle tracking to assess how diversion operations (open, closed) and tributary discharge levels (low, median, high) influence water exposure time—the cumulative duration water remains in a domain, including re-entry. Exposure time was analyzed based on the time required for 50%, 75%, and 90% of released particles ((Formula presented.), (Formula presented.), and (Formula presented.)) to leave a defined region of interest (ROI). Results show …


Does Non-Idealism Entail Particularism?, John Lawless Jul 2025

Does Non-Idealism Entail Particularism?, John Lawless

Faculty Publications - Philosophy

No abstract provided.


A Quantitative Study Of Presidents At Public And Private 4-Year Historically Black Colleges And Universities, Richard J. Gallot, Jr. Jul 2025

A Quantitative Study Of Presidents At Public And Private 4-Year Historically Black Colleges And Universities, Richard J. Gallot, Jr.

PhD in Organizational Leadership

There has been a notable increase in presidential turnover at historically Black colleges and universities (HBCUs), leading to significant leadership challenges (Freeman & Gasman, 2014). Abrupt leadership changes create instability that impacts recruitment and retention of students, faculty, and staff, as well as overall morale on campuses (Gasman et al., 2010). Despite the importance of effective leadership, there is limited research specifically focusing on HBCU presidencies (Freeman & Palmer, 2020). Although the American Council on Education (ACE) has surveyed college and university presidents every 5 years since 1986, few studies have investigated HBCU presidents as a distinctive group. Existing research …


Overexpression Of The Polyhydroxybutyrate Depolymerase Gene Of Streptomyces Nymphaeiformis In Streptomyces Lividans Tk24, Ana Laura Mumic Montans, Stephan Francis Baron Jul 2025

Overexpression Of The Polyhydroxybutyrate Depolymerase Gene Of Streptomyces Nymphaeiformis In Streptomyces Lividans Tk24, Ana Laura Mumic Montans, Stephan Francis Baron

ASPIRE 2026

Polyhydroxyalkanoates (PHAs), commonly known as biodegradable plastics, are polymers of hydroxyalkanoate monomers that are produced by over 75 genera of bacteria [1]. The most common PHA is polyhydroxybutyrate (PHB), which is composed of 3-hydroxybutyrate (3HB) monomers. PHB is degraded to 3HB by PHB depolymerases [2]. Streptomyces nymphaeiformis is a Gram positive, filamentous bacterium with a genomic G+C content of ~70% [3]. Production of PHB depolymerase in this organism is induced by the presence of PHB and 3HB, with maximal activity observed after 24 to 48 hrs, [4]. The PHB depolymerase protein can be purified from cell-free supernatants of PHB-grown cells …


Experimental Determination Of Diffusion Flame Extinction Boundaries Over A Pmma Sphere: The Effect Of Sub-Surface Solid Heating, James S. T'Ien, Chengyao Li Jul 2025

Experimental Determination Of Diffusion Flame Extinction Boundaries Over A Pmma Sphere: The Effect Of Sub-Surface Solid Heating, James S. T'Ien, Chengyao Li

Faculty Scholarship

The SoFIE-GEL (Solid Fuel Ignition and Extinction-Growth and Extinction Limit) microgravity combustion experiment was recently conducted aboard the International Space Station (ISS). In these tests, diffusion flame extinction limits of 4-cm diameter PMMA (polymethacrylate) spheres were determined as a function of forced flows (0.2 to 80 cm/s), oxygen concentrations (13 % to 34 %) and pressure (0.15–1.1 atm). In particular, the effect of sample heat-up is investigated. The sample surface layer is preheated by the ignitor and the diffusion flame itself before the extinction procedure (e.g. flow velocity decrease or increase or oxygen decrease) is implemented. The degree of sample …


Tissue Engineering: History, Principles, Applications, Challenges, And Future Work, Alexa Cesari, Ms Jul 2025

Tissue Engineering: History, Principles, Applications, Challenges, And Future Work, Alexa Cesari, Ms

Student Papers, Posters & Projects

Tissue engineering is a comprehensive and cutting-edge field that leverages principles from multiple scientific disciplines to assist in regenerative medicine. It is defined by the most basic structure of the human body, the cell. When an injury occurs, cells send signals to initiate wound healing processes. In most cases, the body is equipped to heal wounds on its own; however, there are instances where wounds are too severe and cannot undergo proper regeneration. When this occurs, alternative measures are taken to assist in wound repair. With numerous advancements made over the years, tissue engineering has become an increasingly common method …


A Late Presentation Of Benign Cephalic Histiocytosis, Madison A. Hackley, Nicholas D. Brownstone, Shayan Waseh, Simo Huang, Jason B. Lee, Sylvia Hsu Jul 2025

A Late Presentation Of Benign Cephalic Histiocytosis, Madison A. Hackley, Nicholas D. Brownstone, Shayan Waseh, Simo Huang, Jason B. Lee, Sylvia Hsu

Department of Dermatology and Cutaneous Biology Faculty Papers

No abstract provided.


The East Palestine Train Derailment: A Complex Environmental Disaster, Lynn T. Singer, Fredrick R. Schumacher, Timothy Ciesielski Jul 2025

The East Palestine Train Derailment: A Complex Environmental Disaster, Lynn T. Singer, Fredrick R. Schumacher, Timothy Ciesielski

Faculty Scholarship

This symposium, The East Palestine Train Derailment: A Complex Environmental Disaster, brought together scientists whose research represented initial scientific responses to the community health impacts of the chemical exposures incurred from a disastrous train derailment and subsequent combustion in East Palestine, Ohio in February, 2023. This derailment and burn led to multiple complex toxic exposures to air, soil and water, including vinyl chloride and butyl acrylate. Presenters described the multi-university consortium formed to assist with developing and communicating data-informed summaries to the affected community. Presenters also reported on the immediate health sequelae experienced by the community and the stress and …


Dynamic Microbiome Responses To Structurally Diverse Anthocyanin-Rich Foods In A Western Diet Context, Mohammed F. Almatani, Giovanni Rompato, Eliza C. Stewart, Marcus Hayden, Jeremy Case, Samuel Rice, Korry J. Hintze, Abby D. Benninghoff Jul 2025

Dynamic Microbiome Responses To Structurally Diverse Anthocyanin-Rich Foods In A Western Diet Context, Mohammed F. Almatani, Giovanni Rompato, Eliza C. Stewart, Marcus Hayden, Jeremy Case, Samuel Rice, Korry J. Hintze, Abby D. Benninghoff

Animal, Dairy, and Veterinary Science Student Research

Background/Objectives: Anthocyanin (ACN)-rich foods are known to influence the gut microbiota composition, but the temporal dynamics and structural specificity of these effects remain poorly understood. This study investigated how distinct ACN-rich fruit supplements impact the gut microbiome over time in the context of a Western-style diet. We hypothesized that ACN-induced microbial shifts would occur rapidly, differ by ACN source, and require continued intake to persist. Methods: C57BL/6J mice were fed the total Western diet (TWD) supplemented with freeze-dried powders from bilberry (BB), tart cherry (TC), chokeberry (CB), elderberry (EB), black currant (BC), or black raspberry (BRB) for 0, 1, 3, …


Copley Connects | Spring/Summer 2025, University Of San Diego Jul 2025

Copley Connects | Spring/Summer 2025, University Of San Diego

Copley Connects Library Newsletter

Message From the Dean | 2

Research and Scholarship Recognition | 3

Featured Collection: Southern Cross | 4

2025 Holleman Scholarship Winners | 6

AI Comes for Digital USD | 7

Pontem Partnership Marks Five Years | 8

Spotlight Jordan Kobayashi | 9

New Faculty at Copley | 9

ACRL Conference in Minneapolis | 10

American Society for Engineering Education (ASEE) Conference | 10

Copley Recognizes Graduating Seniors with Bookplates | 11

Top 10 Digital USD Downloads for the 2024–2025 Academic Year | 12

New Resources for Fall 2025 | 13

Seguimos Creando Enlaces Conference | 13

Copley Reads | …


Education Equity For Transgender And Gender-Diverse Persons In India: Insights Into Implementation Hurdles, Dipika Jain, Natasha Aggarwal, Kanmani Ray, Surbhi Karwa, Disha Chaudhari, Rishav Devrani Jul 2025

Education Equity For Transgender And Gender-Diverse Persons In India: Insights Into Implementation Hurdles, Dipika Jain, Natasha Aggarwal, Kanmani Ray, Surbhi Karwa, Disha Chaudhari, Rishav Devrani

Michigan Journal of Gender & Law

Part I of this article presents international, global, and national approaches to the right to education for transgender and gender-diverse persons. It then describes the Indian approach—the NALSA judgment and the Transgender Persons Act. Finally, it provides anecdotal insight into the lived experiences of transgender and gender-diverse persons and the marginalization they face.

Part II outlines: (i) the rationale of this study, (ii) the research methodology, and (iii) the questions in the right to information requests, which have formed the basis for investigating the landscape of education rights for transgender and gender-diverse students.

Part III provides an overview of the …


Town Of Lee, New Hampshire Annual Town Report June 30, 2025, Lee Town Representatives Jul 2025

Town Of Lee, New Hampshire Annual Town Report June 30, 2025, Lee Town Representatives

Lee, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.


2025-2026 Self-Study Report For The Bachelor Of Science In Engineering, Kettering University Jul 2025

2025-2026 Self-Study Report For The Bachelor Of Science In Engineering, Kettering University

ABET Engineering

This document is intended to fulfill the self-study requirement associated with ABET’s 2025-2026 initial accreditation review of the Bachelor of Science in Engineering program at Kettering University.


Gold & Blue, Summer 2025, St. Mary's University - San Antonio, Texas Jul 2025

Gold & Blue, Summer 2025, St. Mary's University - San Antonio, Texas

Gold & Blue

This is the Summer 2025 edition of Gold & Blue, which is St. Mary's University's official alumni magazine.


Distribution Of Secretor Status In A Sample Of Iraqi Population Based On Their Gender, Blood Groups And Body Mass Index, Ola Amer Jasim Jul 2025

Distribution Of Secretor Status In A Sample Of Iraqi Population Based On Their Gender, Blood Groups And Body Mass Index, Ola Amer Jasim

Al-Esraa University College Journal for Medical Sciences

The ABO blood group system was divided into four phenotypes i.e., A, B, AB, and O following its discovery by Karl Landsteiner in 1990. Antigens of the ABO blood group can be found in bodily fluids such as the salivary and digestive fluids. Furthermore, People are classified as ``secretors'' or ``non-secretors'' based on their ability to secrete (ABO blood group) antigens in body fluids. The control-based study was conducted on 342 Iraqi adults who were presented at educational institutions. The study lasted from October 2022 to February 2023 and aimed to determine the relationship between secretor status with (gender, blood …


Evaluation Of Phytotoxicity Of Greenly Treated Domestic Wastewater By Spent Plant Leaf Powders, Adnan Ahmad Ali-Nizam, Magdi Amin, Isam Shaker Hemza Jul 2025

Evaluation Of Phytotoxicity Of Greenly Treated Domestic Wastewater By Spent Plant Leaf Powders, Adnan Ahmad Ali-Nizam, Magdi Amin, Isam Shaker Hemza

Al-Esraa University College Journal for Medical Sciences

Health and ecosystems face widespread, impactful problems. Untreated wastewater is discharged into waterways and lands in most developing countries, containing harmful substances and pathogens. WHO estimates that nearly 1.7 billion people drink contaminated water in developing countries, and that contamination leads to nearly 500,000 diarrheal deaths each year. However, existing treatment methods are insufficient to remove dissolved substances and specific pollutants; they are very expensive, energy-intensive, require advanced technologies, and high operational skills. The process of removing pollutants from wastewater using plant waste powders involves a combination of mechanisms, including adsorption, complexation, and ion exchange. These processes are characterized by …


The Mysterious Power Of Land Use Law: Constructing A Framework Law For Climate Resilient Development, John R. Nolon, Maureen Hartwell Jul 2025

The Mysterious Power Of Land Use Law: Constructing A Framework Law For Climate Resilient Development, John R. Nolon, Maureen Hartwell

Elisabeth Haub School of Law Faculty Publications

This Article introduces and explains Climate Resilient Development (CRD), which is relied upon by the Intergovernmental Panel on Climate Change (IPCC) as a primary method of managing climate change. CRD "integrates adaptation measures and their enabling conditions with mitigation to advance sustainable development for all." 1 CRD illuminates the close relationship between adaptive and mitigative development and land use law, particularly the authority delegated to local governments to regulate and incentivize private land development and conservation. The Article unveils a legal structure that is followed in most states to organize local laws that affect land development; as such, it facilitates …


Wnt-Directed Cxcl12-Expressing Apical Papilla Progenitor Cells Drive Tooth Root Formation, Mizuki Nagata, Gaurav T Gadhvi, Taishi Komori, Yuki Arai, Hiroaki Manabe, Angel Ka Yan Chu, Ramandeep Kaur, Meer Ali, Yuntao Yang, Chiaki Tsutsumi-Arai, Yuta Nakai, Yuki Matsushita, Nicha Tokavanich, W Jim Zheng, Joshua D Welch, Noriaki Ono, Wanida Ono Jul 2025

Wnt-Directed Cxcl12-Expressing Apical Papilla Progenitor Cells Drive Tooth Root Formation, Mizuki Nagata, Gaurav T Gadhvi, Taishi Komori, Yuki Arai, Hiroaki Manabe, Angel Ka Yan Chu, Ramandeep Kaur, Meer Ali, Yuntao Yang, Chiaki Tsutsumi-Arai, Yuta Nakai, Yuki Matsushita, Nicha Tokavanich, W Jim Zheng, Joshua D Welch, Noriaki Ono, Wanida Ono

Faculty, Staff and Student Publications

The tooth root is a critical component of the tooth anchored to surrounding alveolar bones. Tooth root formation is driven by cells in the apical papilla (AP) that generate new dentin-forming odontoblasts at the root-forming front. Mesenchymal stem cells have been isolated from AP for regenerative use; however, how AP cells physiologically coordinate tooth root formation remains undefined. We find that CXCL12+ cells emerge in AP under hypoxic environments at the onset of tooth root formation. Using Cxcl12-creER-based cell-lineage analysis, we further find that CXCL12+ AP cells contribute not only to odontoblasts but also to cementum-forming cementoblasts of the elongating …


Resident Case Series: The Utility Of The Athletic Shoulder Test Using Wireless Portable Force Plates For Measuring Peak Force In Ncaa Division One Collegiate Quarterbacks, Carmen Sclafani, Patrick Smith, Terry Mchugh, Patricia Crane Jul 2025

Resident Case Series: The Utility Of The Athletic Shoulder Test Using Wireless Portable Force Plates For Measuring Peak Force In Ncaa Division One Collegiate Quarterbacks, Carmen Sclafani, Patrick Smith, Terry Mchugh, Patricia Crane

Department of Rehabilitation Medicine Faculty Papers

BACKGROUND: Given the high incidence of shoulder injuries among quarterbacks due to the repetitive stress of the overhead throwing motion, there is a need for targeted, sport-specific assessments that reflect the functional demands of throwing. The Athletic Shoulder (ASH) test, previously validated in rugby and baseball populations, offers a potential solution for upper extremity strength assessment in football quarterbacks. The primary purpose of this case series was to explore the feasibility of conducting the ASH test as a method for evaluating upper extremity strength in overhead athletes, specifically collegiate quarterbacks.

STUDY DESIGN: Case series.

METHODS: Three NCAA Division I quarterbacks …


Creating Blood Analogs To Mimic Steady-State Non-Newtonian Shear-Thinning Characteristics Under Various Thermal Conditions, Hang Yi, Alexander Wang, Christopher Wang, Jared Chong, Chungyiu Ma, Luke Bramlage, Bryan Ludwig, Zifeng Yang Jul 2025

Creating Blood Analogs To Mimic Steady-State Non-Newtonian Shear-Thinning Characteristics Under Various Thermal Conditions, Hang Yi, Alexander Wang, Christopher Wang, Jared Chong, Chungyiu Ma, Luke Bramlage, Bryan Ludwig, Zifeng Yang

Mechanical and Materials Engineering Faculty Publications

Blood analogs are widely employed in in vitro experiments such as particle image velocity (PIV) to secure hemodynamics, assisting pathophysiological diagnoses of neurovascular and cardiovascular diseases, as well as pre-surgical planning and intraoperative orientation. To obtain accurate physical parameters, which are critical for diagnosis and treatment, blood analogs should exhibit realistic non-Newtonian shear-thinning features. In this study, two types of blood analogs working under room temperature (293.15 K) were created to mimic the steady-state shear-thinning features of blood over a temperature range of 295 to 312 K and a shear range of 1~250 s−1 at a hematocrit of ~40%. Type …


Modeling The Impact Of Explosive Volcanism On Biogeochemical Cycling At The Peak Of The Late Paleozoic Icehouse, Lily S. Pfeifer, Qingting Wu, Ying Cui, Gerilyn S. Soreghan Jul 2025

Modeling The Impact Of Explosive Volcanism On Biogeochemical Cycling At The Peak Of The Late Paleozoic Icehouse, Lily S. Pfeifer, Qingting Wu, Ying Cui, Gerilyn S. Soreghan

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

The peak of the Late Paleozoic Ice Age (LPIA) coincided with atmospheric carbon dioxide (pCO2) lows, and large-magnitude fluctuations in glacial-interglacial pCO2, but the driver(s) for pCO2 drawdown at this time remain debated. Backed by parameters for the frequency and magnitude of Late Carboniferous volcanism derived from the rock record, we apply an intermediate complexity Earth system model to evaluate the biogeochemical impacts of ash-borne nutrients from frequent (decadal) and explosive silicic volcanism on nutrient cycling ca. 310–300 Ma. Results show that volcanic perturbations result in negligible changes in marine particulate organic carbon export concurrent with sustained increases in pCO2 …


Influence Of Field Trips On Adolescent Environmental Stewardship: Examining The Role Of The Dominant Social Paradigm, Gita Bhushal, Meghann Smith, Pankaj Lal, Neeraj Vedwan Jul 2025

Influence Of Field Trips On Adolescent Environmental Stewardship: Examining The Role Of The Dominant Social Paradigm, Gita Bhushal, Meghann Smith, Pankaj Lal, Neeraj Vedwan

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

Promoting environmental stewardship among youths is crucial for inspiring collaborative, multi-generational actions to tackle long-term environmental challenges. This research study explores the impact of an environmental education (EE) field trip, which highlighted wastewater management and renewable energy technology, on high school students using the revised new ecological paradigm (NEP) scale as a key metric in a pre-post survey, which uses traditionally pro (NEP) and anti (dominant social paradigm, DSP) conservationist statements to measure beliefs towards the environment. When applying the Wilcoxon signed-rank test (null hypothesis t = 0, no change) to the series of environmental stewardship action questions “___ is …


Ion Channel Gating Probability Of Voltage-Gated Hnav1.1: Role Of Beta Subunits And The Associated Impacts On Epilepsy, Georgia Blue Hill, Soha Haniyyah, Diana M. Cortez, James R. Groome Jul 2025

Ion Channel Gating Probability Of Voltage-Gated Hnav1.1: Role Of Beta Subunits And The Associated Impacts On Epilepsy, Georgia Blue Hill, Soha Haniyyah, Diana M. Cortez, James R. Groome

Idaho Conference on Undergraduate Research

Voltage-gated sodium channels are essential for initiating action potentials in neurons. Mutations in the human brain sodium channel hNaV1.1 ion channel are associated with a large number of neurological disorders, such as epilepsy. Despite its clinical relevance, there is still much to characterize about the specific effects of how these mutations affect sodium channel behaviour, including the role of the smaller beta subunits. To investigate this, hNaV1.1 channels were expressed with varying beta subunits (beta 1,beta 2, or none) in Xenopus oocytes. Electrophysiology was utilized to record sodium currents and measure the probability of sodium channels activating (open state) or …