Digital Commons Network^™

Machine-Learning Driven Strategies For Adapting Immunotherapy In Metastatic Nsclc, Maliazurina B Saad, Qasem Al-Tashi, Lingzhi Hong, Vivek Verma, Wentao Li, Daniel Boiarsky, Shenduo Li, Milena Petranovic, Carol C Wu, Brett W Carter, Girish S Shroff, Tina Cascone, Xiuning Le, Yasir Y Elamin, Mehmet Altan, Simon Heeke, Ajay Sheshadri, Joe Y Chang, Percy P Lee, Zhongxing Liao, Don L Gibbons, Ara A Vaporciyan, J Jack Lee, Ignacio I Wistuba, Cara Haymaker, Seyedali Mirjalili, David Jaffray, Justin F Gainor, Yanyan Lou, Alessandro Di Federico, Federica Pecci, Mark Awad, Biagio Ricciuti, John V Heymach, Natalie I Vokes, Jianjun Zhang, Jia Wu

Faculty, Staff and Student Publications

Immune checkpoint inhibitors (ICIs), either as monotherapy (ICI-Mono) or combined with chemotherapy (ICI-Chemo), improves survival in advanced non-small cell lung cancer (NSCLC). However, prospective guidance for choosing between these options remains limited, and single-feature biomarkers like PD-L1 prove inadequate. We develop a machine learning model using clinicogenomic data from four cohorts (MD Anderson n = 750; Mayo Clinic n = 80; Dana-Farber n = 1077; Stand Up To Cancer n = 393) to predict individual benefit from adding chemotherapy. Benefit scores are calculated using five distinct functions derived from 28 genomic and 6 clinical features. Our integrated model, A-STEP (Attention-based …

Feasibility Of Manufacturing And Antitumor Activity Of Til For Advanced Endometrial Cancers, Yongliang Zhang, Kathleen N Moore, Amir A Jazaeri, Judy Fang, Ilabahen Patel, Andrew Yuhas, Patrick Innamarato, Nathan Gilbert, Joseph W Dean, Behzad Damirchi, Joe Yglesias, Rongsu Qi, Michelle R Simpson-Abelson, Erwin Cammaart, Sean R R Hall, Hequn Yin

Faculty, Staff and Student Publications

Lifileucel, a tumor-infiltrating lymphocyte (TIL) cell therapy approved for advanced melanoma, demonstrates promise for treating other solid tumors, including endometrial cancer (EC). The current study evaluates the feasibility of manufacturing TILs from EC tumors using Iovance’s proprietary 22-day Gen2 manufacturing process. Key parameters, including TIL yield, viability, immune phenotype, T-cell receptor clonality, and cytotoxic activity, were assessed. Of the 11 EC tumor samples processed at research scale, 10 (91%) successfully generated >1 × 109 viable TIL cells, with a median yield of 1.1 × 1010 cells and a median viability of 82.8%. Of the four EC tumor samples processed at …

Quantifying The Economic Burden Of Cancer In California Using Advanced Analytics, Terence Casey Kelley

Walden Dissertations and Doctoral Studies

Cancer imposes a significant and multifaceted economic burden on California’s health care system and communities. Despite extensive national data, California-specific cost analyses have been outdated and limited. This study quantified California’s cancer-care burden through a quantitative, cross-sectional design grounded in the cost-of-illness framework and human-capital theory. A retrospective modeling approach used 2015–2023 data from the California Cancer Registry, National Cancer Institute, National Program of Cancer Registries, and California’s all-payer claims database. California’s economic burden from cancer was estimated using a meta-analysis of national cost data, which was then applied to state-specific cancer incidence, prevalence, and mortality through a multicriteria decision …

Scarna1 Expression Levels Affect Alternative Splicing Of Mrna., Madeleine Brown, Brittnei Earl, Michael Filla, Nataliya Kibiryeva, James E. O'Brien, Douglas C. Bittel

Manuscripts, Articles, Book Chapters and Other Papers

Our previous research identified 12 small Cajal body-specific RNAs (scaRNAs) with reduced expression in the right ventricle in infant patients with tetralogy of Fallot. Likewise, we showed that there were significant changes in mRNA processing in the RV in these patients. ScaRNAs play a crucial role in the biochemical maturation of spliceosomal RNAs (pseudouridylation and 2'-O-methylation). We showed that variations in scaRNA1 levels resulted in changes in alternative splicing in human cells. To investigate further the role that scaRNAs play in mRNA processing, we examine here the impact of knocking down scaRNA1 in quail myoblast cells (Coturnix japonica, …

Optimizing Thermal Performance Of Ag-Mgo/H2O Hybrid Nanofluid Flow In A Quarter-Circular Cavity Using Response Surface Methodology And Artificial Neural Network, M.S. Alam, M.N. Huda, M.M. Rahman, M. Al-Lawati

Sultan Qaboos University Journal For Science

This research analyzes the optimization of the thermal performance of the natural convective flow of Ag-MgO/H2O hybrid nanofluid within a quarter-circular cavity utilizing response surface methodology (RSM) and artificial neural network (ANN) techniques through a non-homogeneous dynamic mathematical model. The Galerkin-weighted residual finite element method numerically solves the governing dimensionless equations and boundary conditions. The numerical results are then used to train ANN and RSM models and evaluate their performance. The results indicated that both models are dependable for this investigation, exhibiting a notably high coefficient of determination for the performance control variable, the average Nusselt number. In addition, the …

Antibacterial Potential Of Tapanuli Orangutan (Pongo Tapanuliensis) Food In Batang Toru Forest Against Escherichia Coli And Salmonella Typhi, Herna Febrianty Sianipar, Wahyu Widoretno, Luchman Hakim, Rezi Rahmi Amolia, Fatchiyah Fatchiyah

Karbala International Journal of Modern Science

Diarrhea is a common disease affecting orangutans, primarily caused by Escherichia coli and Salmonella typhi bacteria. To treat this disease, antibacterial food sources are essential as therapeutic agents for orangutans. The fruits consumed by Tapanuli orangutans include Campnosperma auriculatum, Agathis borneensis, Artocarpus heterophyllus, Castanopsis argantea, and Aglaia tomentosa. This study aims to examine the amino acid and phytochemical components with potential antibacterial properties in these five fruit species and their inhibitory effects on E. coli and S. typhi growth through cell lysis, observed using a Scanning Electron Microscope (SEM). The samples were tested for amino acids, phytochemicals, vitamin C content, …

Uptake, Distribution, And Activity Of Pluronic F68 Adjuvant In Wheat And Its Endophytic Bacillus Isolate, Anthony Cartwright, Mohammad Zargaran, Anagha Wankhade, Astrid Jacobson, Joan E. Mclean, Anne J. Anderson, David W. Britt

Biological Engineering Student Research

Surfactants are widely utilized in agriculture as emulsifying, dispersing, anti-foaming, and wetting agents. In these adjuvant roles, the inherent biological activity of the surfactant is secondary to the active ingredients. Here, the hydrophilic non-ionic surface-active tri-block copolymer Pluronic^® F68 is investigated for direct biological activity in wheat. F68 binds to and inserts into lipid membranes, which may benefit crops under abiotic stress. F68’s interactions with Triticum aestivum (var Juniper) seedlings and a seed-borne Bacillus spp. endophyte are presented. At concentrations below 10 g/L, F68-primed wheat seeds exhibited unchanged emergence. Root-applied fluorescein-F68 (fF68) was internalized in root epidermal cells and …

Assay Development For The Identification Of Novel Therapeutics To Treat Heart Failure And Skeletal Muscle Disorders, Micah C. Israel, Brooke Ferkull, Thomas Goyne

Summer Interdisciplinary Research Symposium

This project is a collaborative effort between Pelagos Pharmaceuticals & Valpo U. Overall goal = develop drugs that will halt &/or reverse congestive heart failure and skeletal muscle disorders by targeting two nuclear receptors: Rev-Erb & the estrogen-related receptors (ERRs). The work reported here is focused on the treatment of mouse myoblasts (skeletal muscle cell precursors) with potential ERR agonists & then looking for protective changes in gene expression.

Exploring Therapeutic Potential Of Low Dose Naltrexone For Fibromyalgia Patients, Lauren Bartlett

Summer Interdisciplinary Research Symposium

Objective: This study aims to compare and evaluate current research on the use and efficacy of low dose naltrexone (LDN) in reducing pain symptoms in patients with fibromyalgia (FM).

Methods: A literature review was conducted using Google Scholar, PubMed, and an Valparaiso University's library database. Search items included "low dose naltrexone" and "fibromyalgia." Studies were included if they focused on LDN treatment in FM populations, emphasizing symptom outcomes and safety profiles. Eligible publications comprised randomized controlled trials, systematic reviews, and clinical studies.

Results: Five studies met inclusion criteria: one randomized, double-blind trial, three systematic reviews, and one randomized, single-blinded clinical …

Ketogenic Metabolic Therapy For Treatment Refractory Mental Illness, Mackenzie R. Ketterhagen

Summer Interdisciplinary Research Symposium

This project explores the potential of Ketogenic Metabolic Therapy (KMT) as adjunctive therapy for refractory mental illness. Evidence suggests that ketogenesis can reverse mitochondrial dysfunction, a pathophysiological feature commonly associated with major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia disorder (SD), leading to measurable improvements in psychiatric symptoms, metabolic biomarkers, and body composition. While preliminary results are promising, current data are based on small sample sizes and short study durations, limiting the generalizability of findings. Therefore, KMT cannot yet be considered a broadly validated adjunctive treatment for severe mental illness. Continued research, particularly longitudinal studies, is essential to determine …

Effect Of Simulated Microgravity On Candida Albicans Amphotericin B Resistance, James Livengood, Patrice G. Bouyer

Summer Interdisciplinary Research Symposium

It is conjectured that exposing Candida albicans (C. albicans) to microgravity increases drug resistance gene expression. To research whether simulated microgravity increases amphotericin B resistance, we inoculated six plates with C. albicans that have been exposed to microgravity (using a clinostat) for 72 hours and six plates with C. albicans exposed to gravity for 72 hours. A disc diffusion (Kirby-Bauer) test was performed as such: the plates were divided into quarters, with 1 disc, either an antifungal or pure water control, placed in each quarter. The test discs were loaded with 10 micrograms (40 microliters) of amphotericin B …

Structural Differential Privacy In Graph Neural Networks, Bibek Giri

Master’s Dissertations

Graph Neural Networks (GNNs) have demonstrated impressive performance across a range of graph-based learning tasks. However, their application to domains with sensitive relational data raises serious privacy concerns, as the graph structure itself may leak confidential information. This thesis investigates a decentralized framework for enforcing edge-level local di!erential privacy (LDP) in graph-structured data. We introduce two mechanisms that perturb a node’s neighborhood in a privacy-preserving yet utility-aware manner. The first approach replaces randomly selected neighbors with feature-similar nodes from the 2-hop neighborhood, ensuring structural realism while preserving degree. The second approach eliminates the need for explicit 2-hop propagation and dummy …

One-Year Clinical Outcomes In Patients With Acute Coronary Syndrome Treated With Clopidogrel Versus Prasugrel Versus Ticagrelor: Results Of The Polish Registry Of Acute Coronary Syndromes (Pl-Acs), Julia M. Umińska, Michał Skrzypek, Małgorzata Ostrowska, Piotr Adamski, Aldona Kubica, Piotr Niezgoda, Robert Gajda, Marek Gierlotka, Bartosz Hudzik, Wiktor Kuliczkowski, Diana A. Gorog, Paul A. Gurbel, Jolanta Siller-Matula, Łukasz Szarpak, Michael Savage, Grzegorz Skonieczny, Udaya Tantry, Przemysław Trzeciak, Eliano P. Navarese, Jacek Kubica, Mariusz Gąsior

Division of Cardiology Faculty Papers

BACKGROUND: Efficient dual antiplatelet therapy is crucial in reducing adverse cardiovascular events in patients with acute coronary syndrome (ACS). Comparative effectiveness between clopidogrel, prasugrel, and ticagrelor remains unclear in real-world settings.

AIMS: The objective was to evaluate one-year clinical outcomes in ACS patients treated with clopidogrel, prasugrel, or ticagrelor using data from the Polish Registry of Acute Coronary Syndromes (PL-ACS).

MATERIAL AND METHODS: This retrospective cohort study analyzed 381 278 ACS patients from the PL-ACS registry from 2009 to 2022, who were treated with clopidogrel, prasugrel, or ticagrelor during hospitalization with a 12-month consistent regimen. The primary outcome was one-year …

Temporal And Generational Changes In Depression Among Young American Adults, Ashley W. Kranjac, Dinko Kranjac, Valentine Chung

Sociology Faculty Articles and Research

The prevalence of depression among young American adults has risen significantly over the past two decades, but the mechanisms that underlie the population-level changes in depressive symptoms severity remain unclear. We used data from the 2005–2023 National Health and Nutrition Examination Survey (NHANES) and hierarchical age–period–cohort (HAPC) analysis to examine developmental (i.e., age), life stage (i.e., period), and generational (i.e., cohort) distribution of depressive symptoms among American adults aged 20–30 years old over an 18-year period. Our model results indicate that the probability of either mild, moderate, or severe depression increased among young adult females and males between 2005 and …

Changing Aspen Stand Structure Following Large Carnivore Restoration In Yellowstone, Luke E. Painter, Robert L. Beschta, William J. Ripple

Aspen Bibliography

Restoration of large carnivores in northern Yellowstone National Park in the late 20th century resulted in a sustained reduction of Rocky Mountain elk (Cervus canadensis) and their herbivory, facilitating new growth of quaking aspen (Populus tremuloides) saplings. In 2020–21, we examined 87 randomly selected, previously sampled aspen stands across northern Yellowstone, combining random plots with stand-wide observations. Forty-three percent of stands contained a new cohort of small trees (5–10 cm dbh), the first documented recruitment of overstory aspen trees in northern Yellowstone since the 1940s. Both aspen saplings ( ≥2 m tall) and small trees were …

Utilizing The Combinatory Power Of Chemotherapeutic Compounds In Triple Negative Breast Cancer Cells, Matthew I. Hyder

Biology Summer Fellows

Breast cancer is the leading cause of cancer-related deaths among women worldwide and the second most common cause of cancer deaths in women in the United States. Genetic variants that increase the risk of breast cancer include mutations in the breast cancer susceptibility genes 1 and 2 (BRCA1 and BRCA2). Apoptosis, or programmed cell death, is a natural process that helps the body remove aged cells. However, in cancer, deregulated apoptotic signaling—especially the activation of anti-apoptotic mechanisms—enables cancer cells to evade this process, leading to uncontrolled proliferation, tumor survival, therapeutic resistance, and cancer recurrence. Most anti-cancer drugs function as chemotherapeutic …

New Paradigms In E. Coli Hemolysin Function And Pathogenesis, Hunter Winston Kuhn

Arts & Sciences Graduate Student Theses and Dissertations

Bacterial pore-forming toxins are potent secreted protein effectors that disrupt cellular ion homeostasis by integrating into the plasma membrane. Among them, the RTX toxin alphahemolysin (HlyA) from uropathogenic Escherichia coli (UPEC) has been extensively studied for its hemolytic activity, broad cell tropism, and role in virulence. HlyA was identified as the first type 1 secreted substrate, with β2 integrin CD18/LFA-1 proposed as its receptor. However, its diverse mechanisms of cellular toxicity and impact on outcomes of urinary tract infection (UTI) have remained incompletely defined. During pyelonephritis, renal epithelial cells are at the front line of infection, directly contacting ascending UPEC …

Study Of Anomalous Variations In Seismic And Non-Seismic Parameters Using Machine Learning Techniques To Develop The Earthquake Forecasting Model In The Himalayan Belt, Senthil Kumar M

Theses and Dissertations

Understanding and forecasting earthquakes is not just about science it’s about saving lives, even as the dynamic and hidden nature of Earth's tectonic processes makes this an intricate challenge. The Himalayan belt is one of the most seismically active regions globally due to the collision of the Indian and Eurasian tectonic plates. Investigating this region is essential for understanding highly complicated tectonic mechanisms and reducing substantial hazards posed to millions of people by persistent and intense seismic events. This study aims to enhance forecasting methodologies by applying machine learning techniques while dealing with the inherent challenges of geological complexity and …

The Influence Of Myocardin Effector Genes On The Tgf-Beta Smad3 Signaling Pathway In Human Pleural Mesothelial Cells, Hema Chandra Hrushi Dusharla

Biotechnology Theses

Pleural Fibrosis (PF) involves excessive extracellular matrix (ECM) deposition, mainly by myofibroblasts, leading to pleural thickening and impaired lung function. Pleural mesothelial cells (PMCs) contribute via mesothelial and mesenchymal transition (MesoMT), triggered by cytokines like TGF-β. Our lab identified Myocardin (MyoCD), a transcriptional co-activator of cardiac and smooth muscle, is a master regulator of pleural fibrosis through interactions with serum response factor (SRF) and Smad2/3 transcription factors which initiate fibrosis signaling. RNA sequencing and qPCR analysis revealed that silencing MyoCD decreased the expression of CTNNB1, MDFI, and Tspan2. MDFI emerged as a potent candidate, as this gene affecting the expression …

Unearthing Evidence For St. Augustine’S Racial Blackness And Paralleling Augustine’S Christian Mystical Religion To Traditional African Religion’S Mysticism, Dillon Cook

Say Something Theological: The Student Journal of Theological Studies

This article undertakes two projects rendering significant ramifications for philosophy/theology, if my assertions are correct. First, the philosopher/theologian known as St. Augustine of Hippo is most saliently recognized as a “white man”; if not a white man, “a European”; if not European, “a man of Rome”; or “Mediterranean”; etc. Outside the intellectual sphere, this is how he is often depicted in art, Penguin Classic books, and so on. Yet ironically, images of Augustine rarely circulate, if at all, as a Black-African-Indigenous person. Was Augustine nonwhite? Evidence is rendered that this is indubitably the case. Could Augustine have been modernly categorized …

Judith Winston, Phd, Nancy J. Brown-Peterson

Miscellaneous Documents

No abstract provided.

Comparing The Mechanical Properties Of Conventional, Milled, And 3d-Printed Occlusal Splint Materials: An In Vitro Study, Sadeem Alzaghran

Master's Theses (2009 -)

Aim: Evidence on the mechanical properties of digitally manufactured occlusal splint materials remains scarce. The aim of this study was to evaluate and compare the mechanical properties of CAD/CAM fabricated occlusal splint materials versus conventionally heat-cured acrylic resin materials. Materials and Methods: A total of 100 specimens were manufactured for the present study. One CAD-CAM milled (ProArt CAD Splint), one heat-polymerized (SR IVOcap Clear), and three 3D-Printed (KeySplint Hard, NightGuard Firm2 and RoDIN Splint 2.0) resin materials were evaluated. Flexural strength, flexural modulus and surface hardness were measured. The three-point flexure test was used for the determination of flexural strength …

Multiple Stressors Effects On The Physiological Performance Of Mytilus Trossulus, M. Christina Vasquez, Alana J. Borer, Claribel Y. Alcantar, Osiris Guinea Zepeda, Camya A. Brazil, Colin Carr, Emma Guerrini Romano, Alexander J. Provenzano, Min Jeon Roh

Biology Faculty Works

Mytilus galloprovincialis and M. trossulus co-occur and hybridize along set biogeographical ranges of temperature and salinity along the Pacific coast, USA. However, the role of physiological traits in mussel distribution remains poorly understood. We investigated metabolic rate, antioxidant activity (superoxide dismutase, catalase), oxidative damage (malondialdehyde content, MDA), and clearance rate of M. trossulus under multiple stressors: 7 days of hyposalinity (20, 28, 34 ppt), followed by an acute heat shock (17, 20, 25 ◦C). We found a significant effect of temperature on metabolic rate, an interaction effect on antioxidant activity, and MDA, and independent temperature and salinity effects on clearance …

Microrna Signatures In Dental Pulp Stem Cells Following Nicotine Exposure, David Vang, Leyla T. Hardin, Nabil Abid, Der Thor, Nan Xiao

Pacific Faculty Work

Background and Objectives: Nicotine is the most well-studied toxic substance in cigarette smoke and e-cigarette vape. However, smoke and vape are composed of other components that have a negative impact on health. The objective of this study is to investigate whether nicotine has a distinctive impact on molecular mechanisms in stem cells. Methods: The cellular impact of nicotine on the regenerative capacity of human dental pulp stem cells (DPSCs) and the microRNA (miRNA) profile was examined. Bioinformatic analysis was performed to identify miRNA-regulated cellular pathways associated with nicotine exposure. These pathways were then compared to those induced by cigarette smoke …

Using The Safety Scissors: Dna Resection Regulation At Dna Double-Strand Breaks And Telomeres, Michael M, Soniat, Logan R. Myler

Department of Biochemistry and Molecular Biology Faculty Papers

DNA resection is a universal process in genome maintenance by which one strand of DNA is degraded, leaving the other strand intact. This sometimes highly processive process is critical for many forms of DNA damage repair, replication-coupled repair, meiotic recombination, and telomere maintenance. Therefore, resection must be tightly regulated to prevent genome instability and promote faithful and accurate repair. Here, we review what is known about how resection functions and how it is controlled, using DNA double-strand break repair and telomere maintenance as examples. We address how resection is regulated in three independent steps: resection initiation, long-range processing, and termination. …

Association Between Homelessness And Maternal Health Outcomes Among Non-Hispanic Black Women In Georgia, Miranda Weaver

Walden Dissertations and Doctoral Studies

Maternal health disparities among homeless non-Hispanic Black women in Georgia represent a critical public health concern, driven by inequitable access to care and elevated risks of adverse pregnancy outcomes. This study examined how homelessness influences perinatal care utilization (timing and frequency of prenatal visits and postpartum checkups) and pregnancy complications (gestational diabetes, hypertension, and depression), and whether these associations differ by geographic context (urban versus rural). Grounded in the Social Determinants of Health framework, the study used a quantitative cross-sectional design, analyzing secondary data (n = 1,540; weighted ≈ 203,571) from Phase 8 (2017–2021) of the Pregnancy Risk Assessment Monitoring …

Sepsis Restructures The Mitochondrial Calcium Uniporter Complex In The Lymphoid Tissues Of Mice And Humans, Xianghong Zhang, Jianguo Lin, Baobo Zou, Jack R Killinger, Andrew C Sayce, Thiagarajan Meyyappan, Zeyu Xiong, Melanie J Scott, Janet S Lee, Matthew R Rosengart

2020-Current year OA Pubs

Survivors of sepsis suffer from an elevated risk of premature death that is not explained by a higher burden of chronic diseases prior to the infection. Nearly 1 out of 4 survivors have persistent elevations of inflammation biomarkers, such as interleukin (IL) 6. These observations suggest that sepsis imparts durable changes to organismal biology. Eukaryotic life depends upon ATP and calcium (Ca

Comparing Dosimetric Outcomes Of Static Imrt And Vmat In Accelerated Partial Breast Irradiation For Medially Located, Left-Sided Tumor Beds, Rani Jamil

Masters Projects

Abstract

Introduction: Accelerated partial breast irradiation (APBI) has emerged as a targeted alternative to whole-breast irradiation for early-stage breast cancer, particularly for patients with medially located, left-sided tumors. Static intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) offer advanced dose conformity, yet no direct comparisons between static IMRT and VMAT have been conducted specifically for medially located, left-sided APBI, a uniquely challenging anatomical subgroup. This study evaluates dosimetric differences between static IMRT and VMAT plans to determine which modality provides superior target coverage and organ-at-risk (OAR) sparing in left-sided APBI.

Methods: Ten patients with medially located left-sided breast …

Physical Activity Mediates Age Differences In Cognition Among Tsimane Forager-Horticulturalists, Phoebe E. Imms, Nikhil N. Chaudhari, Daniel Cummings, Daniel Eid Rodriguez, Giuseppe Barisano, Paul L. Hooper, M. Katherine Sayre, Edmond Seabright, Randall C. Thompson, M. Linda Sutherland, James D. Sutherland, Benjamin C. Trumble, Michael Gurven, Jonathan Stieglitz, Caleb E. Finch, Hillard S. Kaplan, Wendy J. Mack, Margaret Gatz, Andrei Irimia

ESI Publications

Background: The Tsimane and Moseten of the Bolivian Amazon are highly physically active and exhibit low rates of cognitive impairment and brain atrophy.

Methods: We use structural equation modelling to examine how their physical activity levels mediate the relationship between (1) age and cognition, and (2) age and cognition via brain volume (BV).

Results: Tsimane males (n = 305, mean ± SD age = 59.94 ± 9.68) and Tsimane females (n = 265, mean ± SD age = 59.28 ± 9.79) exhibit significantly higher levels of physical activity than Moseten males (n = 106, mean ± SD …

Optimizing Tobacco-Free Workplace Programs: Applying Rapid Qualitative Analysis To Adapt Interventions For Texas Healthcare Centers Serving Rural And Medically Underserved Patients, Hannah Wani, Maggie Britton, Tzuan A Chen, Ammar D Siddiqi, Asfand B Moosa, Teresa Williams, Kathleen Casey, Lorraine R Reitzel, Isabel Martinez Leal

Faculty, Staff and Student Publications

Background: Tobacco use is disproportionately high in rural areas, contributing to elevated cancer mortality, yet it often goes untreated due to limited access to care, high poverty and uninsured rates, and co-occurring substance use disorders (SUDs). This study explored the utility of using rapid qualitative analysis (RQA) to guide the adaptation of a tobacco-free workplace program (TFWP) in Texas healthcare centers serving adults with SUDs in medically underserved areas.

Methods: From September-December 2023 and May-July 2024, we conducted 11 pre-implementation, virtual semi-structured group interviews focused on adapting the TFWP to local contexts (N = 69); 7 with providers (n …