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2025

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Comparison Of Stem Student Reflections Of Their Undergraduate Research Experiences: Cures Vs. Apprentice Model, Chazzidy Harper Jul 2025

Comparison Of Stem Student Reflections Of Their Undergraduate Research Experiences: Cures Vs. Apprentice Model, Chazzidy Harper

Master's Theses

Undergraduate research is widely recognized as a high-impact educational practice that promotes engagement and academic success in STEM. However, limited research has examined how different research formats, particularly course-based undergraduate research experiences (CUREs) and the apprentice model, shape student experiences. This study investigates undergraduate research (UR) course characteristics and student reflections across STEM disciplines at Kennesaw State University (KSU), focusing on differences between CURE and apprentice experiences. A mixed-methods analysis was conducted on 809 student reflections and 169 course syllabi spanning biology, chemistry, physics, and mathematics, computing, data science, software engineering, and information technology, psychological science, and engineering. Demographic data …


Table Of Contents Jul 2025

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.


Effects Of Perfluorooctanoic Acid (Pfoa) And Elevated Salinity On Growth, Reproduction, And Movement Of Physa Acuta, Juana Baudrix, Andrea Rizzo, Samuel Richardson, Jason Doll, Daniel Elias Jul 2025

Effects Of Perfluorooctanoic Acid (Pfoa) And Elevated Salinity On Growth, Reproduction, And Movement Of Physa Acuta, Juana Baudrix, Andrea Rizzo, Samuel Richardson, Jason Doll, Daniel Elias

Journal of the South Carolina Academy of Science

Freshwater ecosystems face increasing threats from pollutants such as perfluorooctanoic acid (PFOA) and elevated salinity. This study examined the effects of PFOA (1.69 µg/L) and elevated salinity (2.5 g/L) on Physa acuta growth, reproduction, and movement over a 21-day exposure. Movement increased across treatments, and reproductive output also increased with salinity and salinity + PFOA, with increased egg sac production in the combined treatment (p < 0.05), while PFOA alone reduced total egg production. Growth was higher with PFOA but decreased in the salinity and salinity + PFOA treatments. Our results suggest that P. acuta increases reproductive output when exposed to combined stressors, prioritizing egg sac production at the cost of movement and growth. These trade-offs may influence P. acuta population dynamics and freshwater ecosystem processes. While this study provides insights into the effects of PFOA and salinity, further research is necessary to understand the long-term ecological consequences in field conditions.


Metabolic Consequences Of Sleep Disorders: A Comprehensive Analysis Of Their Role In Diabetes, Victoria S. Parma Jul 2025

Metabolic Consequences Of Sleep Disorders: A Comprehensive Analysis Of Their Role In Diabetes, Victoria S. Parma

Journal of the South Carolina Academy of Science

The prevalence of type 2 diabetes continues to grow globally, and more strategies are needed to combat this public health problem. Considering the link between sleep problems and risk of type 2 diabetes, the objective of this review is to discuss the experimental and epidemiological evidence underlying the link between sleep disturbances (such as insomnia, circadian rhythm disorders, and obstructive sleep apnea), and the development of insulin resistance and glucose intolerance, which are impairments that can eventually result in type 2 diabetes. In order to explore this, PubMed and Google Scholar were utilized to find pertinent peer-reviewed publications, reviews, and …


High Spatial Resolution Crop Type And Land Use Land Cover Classification Without Labels: A Framework Using Multi-Temporal Planetscope Images And Variational Bayesian Gaussian Mixture Model, Minh Tri Le Jul 2025

High Spatial Resolution Crop Type And Land Use Land Cover Classification Without Labels: A Framework Using Multi-Temporal Planetscope Images And Variational Bayesian Gaussian Mixture Model, Minh Tri Le

Mathematics, Physics, and Computer Science Faculty Articles and Research

Previous studies often combined high spatial resolution data (e.g., PlanetScope) with wider spectral range data (e.g., Sentinel-2) and relied on supervised classification methods to produce land use and land cover (LULC) maps. This study proposed a new unsupervised framework to generate crop type and LULC maps at high spatial resolution (< 5 m) using available PlanetScope data solely without requiring ground truths. We used PlanetScope surface reflectance images and their derived spectral indices during growing seasons to create multi-temporal input features, which were fed into an unsupervised Variational Bayesian Gaussian Mixture Model (VBGMM). The VBGMM, unlike the traditional unsupervised classification methods, (1) first estimated optimal parameters that are most suitable based on the input features and then (2) assigned pixels to the cluster with maximum posteriori probability of a mixture of several Gaussian distributions. The crop type and LULC maps were then generated by labeling the derived clusters using the best possible assignment method, referring to the existing crop type or LULC products. We evaluated the produced PlanetScope-based crop type and LULC maps using true labels, corresponding reference maps, and other unsupervised classification methods. The results demonstrated the robustness and effectiveness of the proposed framework in mapping crop types and LULC at 3–5 m pixels across various ecosystems, climate zones, and human-managed landscapes. The spatial patterns of PlanetScope-based maps were (1) highly comparable with all the reference datasets at 10–30 m spatial resolution and (2) better than the traditional GMM and K-means clustering methods. The VBGMM produced classification maps with high confidence, yielding class probabilities above 0.9 for over 90 % of all study areas. The area percentage for all crop type and LULC classes agreed well with their reference maps, with R2 of 0.95 and RMSE of 1.04 %. The confusion matrices using true labels indicated that PlanetScope-based maps achieved a higher overall accuracy of 84 % than the supervised referenced maps of 81 %. Besides, the entropy comparison showed that our framework-based maps were better at capturing fine-scale features such as developed areas within cities that commonly mix with open space and vegetation, deforestation and cropland conversion in South America, smallholder croplands in Africa and Asia, and generating homogeneous crop fields in North America. This study further highlighted the potential for future research to implement our proposed framework to generate timely and extensive annotated datasets, which can be used for operationally training machine learning models to map crop types and LULC, track deforestation, detect wildfires, and delineate flooded areas at larger scales using medium/coarse Earth observations.


Ionic Liquid Enhanced Proton Transfer For Neutral Oxygen Evolution Reaction, Ming-Xing Chen, Nian Liu, Zi-He Dua, Jing Qi, Rui Cao Jul 2025

Ionic Liquid Enhanced Proton Transfer For Neutral Oxygen Evolution Reaction, Ming-Xing Chen, Nian Liu, Zi-He Dua, Jing Qi, Rui Cao

Journal of Electrochemistry

The development of highly active catalyst in pH-neutral media for oxygen evolution reaction (OER) is critical in the field of renewable energy storage and conversion. Nevertheless, the slow kinetics of proton-coupled electron transfer (PCET) hinders the overall OER efficiency. Herein, we report an ionic liquid (IL) modified CoSn(OH)6 nanocubes (denoted as CoSn(OH)6-IL), which could be prepared through a facile strategy. The modified IL would not change the structural characteristics of CoSn(OH)6, but could effectively regulate the local proton activity near the active sites. The CoSn(OH)6-IL exhibited higher intrinsic OER performances than the pristine …


Immunosuppressive Formulations For Immunological Defense Against Traumatic Brain Injury, Abhirami Thumsi, Abhinav P. Acharya, Jeffrey Capadona, Sanmoy Pathak, Taravat Khodaei, Madan Mohan Chandra Sekhar Jaggarapu, Abhirami P. Suresh Jul 2025

Immunosuppressive Formulations For Immunological Defense Against Traumatic Brain Injury, Abhirami Thumsi, Abhinav P. Acharya, Jeffrey Capadona, Sanmoy Pathak, Taravat Khodaei, Madan Mohan Chandra Sekhar Jaggarapu, Abhirami P. Suresh

Faculty Scholarship

Traumatic brain injury (TBI) and subsequent neurodegeneration is partially driven by chronic inflammation both locally and systemically. Yet, current clinical intervention strategies do not mitigate inflammation sequelae necessitating the development of innovative approaches to reduce inflammation and minimize deleterious effects of TBI. Herein, a subcutaneous formulation based on polymer of alpha-ketoglutarate (paKG) delivering glycolytic inhibitor PFK15 (PFKFB3 inhibitor, a rate limiting step in glycolysis), alpha-ketoglutarate (to fuel Krebs cycle) and peptide antigen from myelin proteolipid protein (PLP139-151) is utilized as the prophylactic immunosuppressive formulation in a mouse model of TBI. In vitro, the paKG(PFK15+PLP) formulation stimulates proliferation of immunosuppressive regulatory …


Seven Um Graduates Earn Fulbright Scholarships, Clara Turnage Jul 2025

Seven Um Graduates Earn Fulbright Scholarships, Clara Turnage

University of Mississippi News

OXFORD, Miss. – Seven recent University of Mississippi graduates have a chance to teach English around the world through the Fulbright U.S. Student Program.


Engineered Bifidobacterium Strains Colonization At Tumor Sites: A Novel Approach To The Delivery Of Cancer Treatments, Rhea Amonkar, Ashley Ann Uy, Pablo Ramirez, Harina Patel, Jae Jin Jeong, Nicole Oyinade Shoyele, Vidhi Vaghela, Ashakumary Lakshmikuttyamma Jul 2025

Engineered Bifidobacterium Strains Colonization At Tumor Sites: A Novel Approach To The Delivery Of Cancer Treatments, Rhea Amonkar, Ashley Ann Uy, Pablo Ramirez, Harina Patel, Jae Jin Jeong, Nicole Oyinade Shoyele, Vidhi Vaghela, Ashakumary Lakshmikuttyamma

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Bacteria-mediated cancer therapy represents a novel and promising strategy for targeted drug delivery to solid tumors. Multiple studies have demonstrated that various Bifidobacterium species can selectively colonize the hypoxic microenvironments characteristic of solid tumors. Leveraging this property, Bifidobacterium has been explored as a delivery vector for a range of anti-cancer approaches such as immunotherapy, nanoformulated chemotherapeutics, and gene therapy. Notably, anti-angiogenic genes such as endostatin and tumstatin have been successfully delivered to colorectal tumors using Bifidobacterium infantis and Bifidobacterium longum, respectively. Additionally, Bifidobacterium bifidum has been employed to transport doxorubicin and paclitaxel nanoparticles to breast and lung tumor sites. …


Selenium Nanoparticles Synthesized By Pulsed Laser Ablation In Liquids For Antimicrobial Applications, Tina Hesabizadeh Jul 2025

Selenium Nanoparticles Synthesized By Pulsed Laser Ablation In Liquids For Antimicrobial Applications, Tina Hesabizadeh

Theses and Dissertations

This study aimed to synthesize selenium nanoparticles (Se NPs) by Pulsed Laser Ablation in Liquids (PLAL) and investigate their antibacterial and biological effects, particularly their impact on cell viability and related biological responses. Spherical amorphous Se NPs were produced by irradiating a selenium target using a combination of bottom- and top-ablation protocols. After autoclaving, the amorphous Se NPs were converted into trigonal Se NPs. Se NPs were characterized by using Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), and Fourier Transform Infrared Spectroscopy (FTIR). The biological effects of Se NPs were quantitatively assessed through evaluations of cell viability and associated …


Distributional Records Of Blanding’S Turtles (Emydoidea Blandingii) In Nebraska, Sam Thede, Dan Fogell, Keith Geluso Jul 2025

Distributional Records Of Blanding’S Turtles (Emydoidea Blandingii) In Nebraska, Sam Thede, Dan Fogell, Keith Geluso

Transactions of the Nebraska Academy of Sciences and Affiliated Societies

Blanding’s Turtle (Emydoidea blandingii) is a species of concern in North America as many populations have declined across its distribution. Environmental factors associated with alteration of natural ecosystems have played a role in declines leading to many isolated populations. Most populations exist in the Great Lakes region with a number of outlying populations, such as Nebraska. Understanding the current distribution of the species will facilitate regional management strategies to protect this species into the future. In Nebraska, Blanding’s Turtles were known from 23 counties prior to this study. Herein, we report on eight new county records, five (Blaine, …


Simulated Walleye Responses To Various Harvest Regulations In A Nebraska Reservoir, Mikael Ranta, Melissa Wuellner, Keith D. Koupal Jul 2025

Simulated Walleye Responses To Various Harvest Regulations In A Nebraska Reservoir, Mikael Ranta, Melissa Wuellner, Keith D. Koupal

Transactions of the Nebraska Academy of Sciences and Affiliated Societies

Recreational fishing provides sociological and economic benefits, and fish populations are managed by state agencies to meet angler expectations. One of the most popular species in Midwest reservoirs are walleye (Sander vitreus), and most of these fisheries have established restrictions on the number and sizes of fish harvested. Regulations are set based on population structure and dynamics and management goals, but often agencies have incomplete information needed to establish regulations. Predictive models can provide insight on population responses and inform managers of the tradeoffs between angler restrictions and population sustainability. Lake McConaughy, Nebraska, supports a popular walleye fishery. …


Intouch Week Of July 28, 2025, New York Medical College Jul 2025

A Qualitative Exploration Of The Potential Benefits Of Nature-Based Approaches For Staff And Children And Young People In Child And Adolescent Mental Health Services, Beth Chapman, Siobhan B. Mitchell, Rebecca Hardwick, Hélène Bonnici, Hazel Banks, Silvana Mareva, Rachel Hayes Jul 2025

A Qualitative Exploration Of The Potential Benefits Of Nature-Based Approaches For Staff And Children And Young People In Child And Adolescent Mental Health Services, Beth Chapman, Siobhan B. Mitchell, Rebecca Hardwick, Hélène Bonnici, Hazel Banks, Silvana Mareva, Rachel Hayes

Peninsula Medical School

Across the UK there are concerns about young people’s mental health, with rates of ill health increasing and referrals to Child and Adolescent Mental Health services (CAMHS) doubling. This study explores the potential benefits of incorporating Nature-Based Approaches (NBAs) within CAMHS. Providers are understaffed, under-resourced and under pressure. NBAs offer a way of working which could address some of these challenges, yet little is known about the potential benefits of NBAs in the context of CAMHS. The project aimed to explore staff understanding of NBAs, and to identify potential benefits of integrating NBAs into practice. Staff within a South of …


Engineered Bifidobacterium Strains Colonization At Tumor Sites: A Novel Approach To The Delivery Of Cancer Treatments, Rhea Amonkar, Ashley Ann Uy, Pablo Ramirez, Harina Patel, Jae Jin Jeong, Nicole Oyinade Shoyele, Vidhi Vaghela, Ashakumary Lakshmikuttyamma Jul 2025

Engineered Bifidobacterium Strains Colonization At Tumor Sites: A Novel Approach To The Delivery Of Cancer Treatments, Rhea Amonkar, Ashley Ann Uy, Pablo Ramirez, Harina Patel, Jae Jin Jeong, Nicole Oyinade Shoyele, Vidhi Vaghela, Ashakumary Lakshmikuttyamma

College of Pharmacy Faculty Papers

Bacteria-mediated cancer therapy represents a novel and promising strategy for targeted drug delivery to solid tumors. Multiple studies have demonstrated that various Bifidobacterium species can selectively colonize the hypoxic microenvironments characteristic of solid tumors. Leveraging this property, Bifidobacterium has been explored as a delivery vector for a range of anti-cancer approaches such as immunotherapy, nanoformulated chemothera- peutics, and gene therapy. Notably, anti-angiogenic genes such as endostatin and tumstatin have been successfully delivered to colorectal tumors using Bifidobacterium infantis and Bifidobacterium longum, respectively. Additionally, Bifidobacterium bifidum has been employed to transport doxorubicin and paclitaxel nanoparticles to breast and lung tumor …


Immunocytochemistry Evaluation Of Fibroblast Response To Garlic (Allium Sativum) Extract Targeting Mmp9: In Vitro And In Silico Approaches, Sri Suciati Ningsih, Endah Zuraidah, Supri Irianti Handayani, Ahmad Ali Irfan Ardiansyah, Ningrum Wahyuni Jul 2025

Immunocytochemistry Evaluation Of Fibroblast Response To Garlic (Allium Sativum) Extract Targeting Mmp9: In Vitro And In Silico Approaches, Sri Suciati Ningsih, Endah Zuraidah, Supri Irianti Handayani, Ahmad Ali Irfan Ardiansyah, Ningrum Wahyuni

Indonesian Journal of Medical Chemistry and Bioinformatics

Background: Fibrosis involves excessive extracellular matrix (ECM) deposition, with matrix metalloproteinase-9 (MMP-9) playing a critical role. Natural compounds targeting MMP-9 may offer therapeutic potential. Objective: This study evaluated the antifibrotic effect of Allium sativum extract on fibroblast cells through in vitro and in silico approaches targeting MMP-9. Methods: Human dermal fibroblasts were treated with A. sativum extract (25, 50, and 100 µg/mL) for 24 and 48 hours. Cell viability was assessed using MTT assay. MMP-9 expression was analyzed via quantitative real-time PCR (qRT-PCR) and immunocytochemistry (ICC). Major garlic compounds were docked to MMP-9 using AutoDock Vina. Results: The 50 µg/mL …


A Novel Microdosimetry-Based Formalism For Cell Survival Modelling Applicable To Hypofractionated Radiotherapy, Oleg N Vassiliev, Radhe Mohan Jul 2025

A Novel Microdosimetry-Based Formalism For Cell Survival Modelling Applicable To Hypofractionated Radiotherapy, Oleg N Vassiliev, Radhe Mohan

Faculty, Staff and Student Publications

Objectives

Hypofractionated radiotherapy requires reliable cell survival models for doses much higher than the standard 2 Gy, for which the linear-quadratic (LQ) model is not applicable. We developed an alternative approach applicable to both low doses and high doses used in hypofractionated treatments and radiobiological experiments.

Approach.

We combined a standard microdosimetric technique with a recently introduced non-LQ cell survival model. Our formulation accounts for cell damage by multi-track events involving any number of particles. This is necessary for modelling cell survival at therapeutic doses. We characterise each cell type by the size �� of the sensitive volume (SV) and …


House Finches Lose Feeding Preferences During Infection: Behavioral Changes With Implications For Pathogen Spread, Francis Edward Tillman Jul 2025

House Finches Lose Feeding Preferences During Infection: Behavioral Changes With Implications For Pathogen Spread, Francis Edward Tillman

Electronic Theses and Dissertations Archive

Foraging is a fundamental behavior that animals use to acquire food resources. Because these resources are critical for survival and reproduction, animals are often thought to forage optimally, maximizing resource intake per unit of time. While the foraging behaviors of healthy animals often align with such predictions, we know little about how or if these predictions hold true in sick animals. This is especially relevant when considering sickness behaviors, or changes in behavior that accompany infection and frequently include lethargy and anorexia, both of which may alter foraging decisions or ability. Because food resources often cause animals to aggregate, a …


Dosimetric Effects Of Pinnacle³ Version 18.0 Advanced Auto-Planning Settings In Oropharyngeal Vmat Optimization, Emily Sanden Jul 2025

Dosimetric Effects Of Pinnacle³ Version 18.0 Advanced Auto-Planning Settings In Oropharyngeal Vmat Optimization, Emily Sanden

Masters Projects

This study evaluated the impact of Pinnacle³ version 18.0 auto-planning advanced settings modulation amount, monitor unit (MU) level, and dose fall-off priority on volumetric modulated arc therapy (VMAT) plan quality for bilateral oropharyngeal cancer. A total of 64 plans were generated using all possible combinations of low, medium, high, and very high settings for each parameter. A standardized base of tongue case was optimized once per plan using a single-time point approach, with planned target volume 1 (PTV1) (6996 cGy) and planned target volume 2 (PTV2) (5412 cGy) coverage evaluated. Each parotid gland, the spinal cord, brainstem, and the oral …


Bold New Bioweapons: Part 2 — Bold Bolstering Of Deterrence And Defense, James Giordano Jul 2025

Bold New Bioweapons: Part 2 — Bold Bolstering Of Deterrence And Defense, James Giordano

Strategic Insights

This commentary, Pt. 2 of the Bold New Bioweapons series, argues that modern biological threats demand a proactive transformation of deterrence and defense strategies. Building on earlier analysis of detection and attribution challenges, Dr. Giordano asserts that emerging life sciences and related technologies, such as synthetic biology, gene editing, and AI-driven bioengineering blur distinctions between legitimate research and weaponizable capabilities. This undermines traditional deterrence frameworks. To address these complexities, the article proposes adaptive, interoperable, and ethical approaches that integrate advanced biosurveillance, precision bioinformatics, AI-enabled threat modeling, and global collaborative governance. It emphasizes the need for robust international norms and resilient …


Association Between Sociocultural Factors, Obesity, And Depression In The Hispanic/Latino Population, Maia Junco Jul 2025

Association Between Sociocultural Factors, Obesity, And Depression In The Hispanic/Latino Population, Maia Junco

Walden Dissertations and Doctoral Studies

The increasing prevalence of obesity and mental health disparities among Hispanic/Latino populations in the United States underscores the need to understand how sociocultural factors shape physical and psychological health. The purpose of this study was to examine how acculturation, diet quality, and fiber intake affect BMI and depressive symptoms over time. The study was guided by acculturation theory and the biopsychosocial model. The study used longitudinal secondary data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) with a sample of N=8,816, including adults who completed examination visits, 1 (2008–2011) and 2 (2014–2017). Path analysis was conducted to assess direct …


Characterization Of The Role Of Rsd-6, A Tudor Domain Protein, In Antiviral Rnai Pathway In Caenorhabditis Elegans, Krishna Prasad Dahal Jul 2025

Characterization Of The Role Of Rsd-6, A Tudor Domain Protein, In Antiviral Rnai Pathway In Caenorhabditis Elegans, Krishna Prasad Dahal

LSU Doctoral Dissertations

RNA interference (RNAi) triggered by virus produced dsRNA intermediate offers robust innate immunity against invading viruses in plants, insects and animals. Caenorhabditis elegans has been extensively used as a model organism to study host virus interaction. Recently, a forward genetic screen identified RNAi spreading deficient-6 (RSD-6), a Tudor domain protein, as a key component in antiviral RNAi pathway against Orsay virus in C. elegans but its contribution in the pathway remained unclear. Here, we generated a rsd-6 null allele using CRISPR-Cas9 genome editing, crossed it with other known RNAi mutants and analyzed Orsay virus replication in them and in combination …


Phosphoglycerate Mutase Regulates Treg Differentiation Through Control Of Serine Synthesis And One-Carbon Metabolism, Wesley H Godfrey, Judy J Lee, Shruthi Shanmukha, Kaho Cho, Xiaojing Deng, Chandra Shekar R Ambati, Vasanta Putluri, Abu Hena Mostafa Kamal, Paul M Kim, Nagireddy Putluri, Michael D Kornberg Jul 2025

Phosphoglycerate Mutase Regulates Treg Differentiation Through Control Of Serine Synthesis And One-Carbon Metabolism, Wesley H Godfrey, Judy J Lee, Shruthi Shanmukha, Kaho Cho, Xiaojing Deng, Chandra Shekar R Ambati, Vasanta Putluri, Abu Hena Mostafa Kamal, Paul M Kim, Nagireddy Putluri, Michael D Kornberg

Faculty, Staff and Students Publications

The differentiation and suppressive functions of regulatory CD4 T cells (Tregs) are supported by a broad array of metabolic changes, providing potential therapeutic targets for immune modulation. In this study, we focused on the regulatory role of glycolytic enzymes in Tregs and identified phosphoglycerate mutase (PGAM) as being differentially overexpressed in Tregs and associated with a highly suppressive phenotype. Pharmacologic or genetic inhibition of PGAM reduced Treg differentiation and suppressive function while reciprocally inducing markers of a pro-inflammatory, T helper 17 (Th17)-like state. The regulatory role of PGAM was dependent on the contribution of 3-phosphoglycerate (3 PG), the PGAM substrate, …


Synthesizing Co-Reading Behaviors: Insights From Graduate Students’ Experience And A Rapid Scoping Review, Watcharasak Sudla, Wannee Kaemkate Jul 2025

Synthesizing Co-Reading Behaviors: Insights From Graduate Students’ Experience And A Rapid Scoping Review, Watcharasak Sudla, Wannee Kaemkate

Higher Learning Research Communications

Objectives: Collaborative reading of research articles is essential for graduate students to develop academic reading skills through peer engagement in knowledge sharing, reflection, and feedback. However, limited information exists about the behaviors indicative of co-reading practices. This study aims to identify behavioral indicators and social participation in students’ co-reading of research articles.

Methods: In this study, we integrated key behavioral indicators of co-reading based on data from interviews with 23 graduate students and a rapid scoping review. The collected data were then subjected to content analysis and data visualization.

Results: The findings categorize individuals involved in co-reading into six groups: …


The Biophysical Basis For Karyopherin-Dependent Ebola Virus Vp24 Nuclear Transport, Junjie Zhao, Bojie Zhang, Olivia Vogel, Benjamin W Walker, Leonard W Ma, Nicole D Wagner, Christopher F Basler, Daisy W Leung, Michael L Gross, Gaya K Amarasinghe Jul 2025

The Biophysical Basis For Karyopherin-Dependent Ebola Virus Vp24 Nuclear Transport, Junjie Zhao, Bojie Zhang, Olivia Vogel, Benjamin W Walker, Leonard W Ma, Nicole D Wagner, Christopher F Basler, Daisy W Leung, Michael L Gross, Gaya K Amarasinghe

2020-Current year OA Pubs

Nucleocytoplasmic trafficking is a highly regulated process that allows the cell to control the partitioning of proteins and nucleic acids between the cytosolic and nuclear compartments. The Ebola virus minor matrix protein VP24 (eVP24) hijacks this process by binding to a region on the NPI-1 subfamily of karyopherin alpha (KPNA) nuclear importers. This region overlaps with the activated transcription factor STAT1 binding site on KPNAs, preventing STAT1 nuclear localization and activation of antiviral gene transcription. However, the molecular interactions of eVP24-KPNA5 binding that lead to the nuclear localization of eVP24 remain poorly characterized. Here, we show that trafficking of eVP24 …


Effects Of Mating System And Adaptedness On The Evolution Of Fitness And Mtdna Copy Number In Mitonuclear Mismatched C. Elegans, Zachary P. Dietz, Devshuvam Banerji, Jennifer A. Sullins, Brent W. Bever, Stephen F. Christy, Ulfar Bergthorsson, Vaishali Katju, Suzanne Estes Jul 2025

Effects Of Mating System And Adaptedness On The Evolution Of Fitness And Mtdna Copy Number In Mitonuclear Mismatched C. Elegans, Zachary P. Dietz, Devshuvam Banerji, Jennifer A. Sullins, Brent W. Bever, Stephen F. Christy, Ulfar Bergthorsson, Vaishali Katju, Suzanne Estes

Biology Faculty Publications and Presentations

Metabolic functioning in nearly all eukaryotes relies on molecular machinery dual-encoded by mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) genomes. The two genomes have sustained an extraordinary degree of cooperation across evolutionary time, preserving the capacity for indispensable processes including oxidative phosphorylation and ATP production, which in turn influence many fitness-related traits. How this cooperation is maintained when one member of the pair is debilitated by deleterious mutation is poorly understood, as is the influence of mutation location (mtDNA or nDNA), mating system, or the potentially compensatory effects of mtDNA copy number changes on the process. We asked whether and …


Discourse Of Indian Knowledge System, Pooja Rai, Rajani Kant Pandey Jul 2025

Discourse Of Indian Knowledge System, Pooja Rai, Rajani Kant Pandey

The World Research of Political Science Journal

Indian Knowledge Systems (IKS) is a section of the Indian Ministry of Education that promotes indigenous knowledge systems. Knowledge assets generated in India are called the Indian Knowledge System (IKS). Mathematics, physics, technology, medicine, astronomy, architecture, philosophy, arts, languages, literature, culture, society, and traditions are included. IKS has traditionally established its own written or verbal texts, methodologies, and standards for knowledge generation, validation, and dissemination. The Indian knowledge system covers all sectors of society, unlike the western one. Indian knowledge system lags western methodology. This deficiency is due to two factors: Indias history as a nation-state and western societys methodology. …


Does Reliance On Kin Erode With Market Integration? A Social Network Perspective, Ruizhe Liu Jul 2025

Does Reliance On Kin Erode With Market Integration? A Social Network Perspective, Ruizhe Liu

Anthropology ETDs

Kinship has long shaped human societies. Yet globalization and market integration (MI) are reshaping social structures. This dissertation investigates how kinship-based networks persist, adapt, or erode amid rapid socioeconomic change. It draws on ethnographic and social network data from 229 Mosuo households in southwest China, a matrilineal society experiencing increasing MI, to examine shifts in everyday cooperation.

The first study analyzes fixed name-generator data and finds a general decline in kin support as MI increases, though with considerable variation. The second study uses count models to explore unbounded support networks, showing that kin ties remain central in reproductive contexts, while …


Multitasking While Walking: How Green Noise And Texting Alter Gait, Kirstin Merrill, Kyle Navarro, Raymond Ngu, Nathan Nguyen, Alex Owyang, Anthony Prajin, Karli Slater, Uyen Truong, Ryan Ye, Eileen Zhu, Sebastian Herrera Vargas, Raj Kumar Chauhan, Sivakumar Rajagopal, Seong Hyun Moon, Michael Shiraishi, Rahul Soangra Jul 2025

Multitasking While Walking: How Green Noise And Texting Alter Gait, Kirstin Merrill, Kyle Navarro, Raymond Ngu, Nathan Nguyen, Alex Owyang, Anthony Prajin, Karli Slater, Uyen Truong, Ryan Ye, Eileen Zhu, Sebastian Herrera Vargas, Raj Kumar Chauhan, Sivakumar Rajagopal, Seong Hyun Moon, Michael Shiraishi, Rahul Soangra

Physical Therapy Faculty Articles and Research

This study examines the combined effects of green noise and texting on gait to understand how multitasking and auditory stimuli affect walking stability. Green noise, associated with relaxation, was the environmental stimulus; texting the cognitive distractor. We hypothesized texting would reduce cadence and stride length, with green noise either stabilizing or disrupting gait. Ten participants walked on a treadmill under five conditions: normal walking (NW), no texting/sound (WNTNS), sound only (WNTS), texting only (WTNS), and texting with sound (WTS). Gait parameters—step length, step width, single support time, and terminal double support time—were analyzed. Step length decreased in WNTS (p …


Delusion Or Faith? Exploring Religious Delusions In Individuals With Schizophrenia Within The Banjar Culture, Nabila Regita Putri Mustafa, Nur’Aulia Maisyarah, Aulia Maulidina, Muhammad Reza Aditya, Muhammad Abdan Shadiqi Jul 2025

Delusion Or Faith? Exploring Religious Delusions In Individuals With Schizophrenia Within The Banjar Culture, Nabila Regita Putri Mustafa, Nur’Aulia Maisyarah, Aulia Maulidina, Muhammad Reza Aditya, Muhammad Abdan Shadiqi

Makara Human Behavior Studies in Asia

Schizophrenia is often characterized by delusions and hallucinations, which often appear as manifestations of religious delusions in the Banjar cultural context. This phenomenon can be understood through the hyper-religiosity theory, which explains excessive religious behavior in individuals with schizophrenia. This qualitative case study aims to identify the forms of religious delusion in individuals with hyper-religiosity and the underlying causal factors. Data were collected through in-depth interviews and observations with 10 informants, comprising four individuals with religious delusions selected using purposive sampling based on their experience of studying Tasawwuf and experiencing religious delusions and six significant others. The findings show that …