Digital Commons Network^™

Experienced Latinx Urban Gardeners In San Jose, Ca, Offer Strategies For Climate Justice And Resilience, Claudia S. Damiani Fontana

Master's Theses

Low-income and underinvested communities will be disproportionately affected by climate change due to limited resources, inadequate infrastructure, and insufficient support systems. Urban gardeners are responding to the need to adapt to new climate conditions while sustaining their food sources and cultural practices. Many have adapted thanks to local interventions led by the government and non-profit agencies. For this study, I partnered with La Mesa Verde (LMV), a gardening and food justice program that works with low-income Latinx families in San José, and I documented the contributions of experienced Latinx gardeners, especially those with agricultural backgrounds, to climate-resilient gardening in San …

Humans Rule? Implications Of Religious Undergraduates’ Changing Environmental Perceptions, J. Robert Nielson

Undergraduate Honors Theses

Addressing climate change requires correctly appraising one’s ethic toward the Earth. Historically, people have navigated their relationship to the natural world via environmental ethics of both religious and secular origin. Aldo Leopold described developing this relationship via the land ethic, a culturally informed process, as “an evolutionary possibility and an ecological necessity.” A land ethic provides a reference point from which individuals and societies make decisions about the Earth and its resources. This thesis considers the evolving land ethic of a young population of conservative Christian students at Brigham Young University with two separate cohorts of non-biology major undergraduates enrolled …

Humor Subversif Dalam Video Musik Balance Ton Quoi Oleh Angele, Nur Annisa Khalish Zarkasya, Airin Miranda

Multikultura

The phenomenon of the #MeToo and #BalanceTonPorc hashtags became the focus of attention in various parts of the world in 2017. It was first popularized by Alyssa Milano on her Twitter account using the #MeToo hashtag, and later followed by Sandra Muller with #BalanceTonPorc in France. The feminist movement on social media inspired many artists and musicians, including Angèle, a singer from Belgium. She released a song and music video titled "Balance Ton Quoi" (2019), in which she expressed that the activist spirit of feminism resides within her, turning her song into a feminist anthem. The messages conveyed in her …

Life-Course And Biography Of Things: Minangkabau Women's Headgear, Attari Putri Denendra, Irmawati Marwoto

International Review of Humanities Studies

Like men, objects also have a biography or life-course. Both biographies are intertwined, so when someone experiences a new life phase transition in their life-course, it will cause changes in the objects attached to them. This is also supported by the statement that the identity is performative. The headgear as one of the elements used by Minangkabau women also represents the identity of the wearer. This research was conducted in three stages: (1) data collection in the form of old photos and literature of Minangkabau women with headgear in Batipuh, Fort de Kock, and Payakumbuh, (2) data processing by analysis …

Impact Of Print Speed And Nozzle Temperature On Tensile Strength Of 3d Printed Abs For Permanent Magnet Turbine Systems, Wirawan Wirawan, Hilmi Iman Firmansyah, Satworo Adiwidodo, Mohammad Sukri Mustapa

Journal of Mechanical Engineering Science and Technology (JMEST)

Operational parameters must be integrated into turbine systems' main components, which are determined by turbine systems' functional requirements. The need for producing component designs more effectively raises the possibility of using additive manufacturing. The study focuses on the optimization of the mechanical properties of the principal components of magnetic turbines manufactured with 3D printers using Acrylonitrile Butadiene Styrene (ABS), by changing the temperature and speed of the nozzle. The approach consisted of modeling a standard test piece in CAD software and producing ABS-based test pieces using a 3D printer with print speeds of 50, 70, 90, and 110 mm/s and …

Characterization Of Bamboo Petung Fiber Reinforced Composites With Environmentally Friendly Enzymes, Rudianto Raharjo, Teguh Dwi Widodo, Redi Bintarto, Fikrul Akbar Alamsyah

Journal of Mechanical Engineering Science and Technology (JMEST)

Natural fiber composites are a good choice for many businesses uses because of their better mechanical properties and are friendly environment. Researchers are currently looking into bamboo petung fiber (BPF) and epoxy composites as alternative to synthetic fibers and products made from petroleum. This study's goal is to improve the overall performance of these composites while reducing the need for non-organic materials. This study used the various concentration of bromelain enzyme in BPF to changes the mechanical and physical properties of epoxy composites made from BPF. Composites were characterized the mechanical properties including tensile strength using tensile tester, impact strength …

Retrotransposon Methylation Profiles And Survival In Black Women With High-Grade Serous Ovarian Carcinoma., Christelle Colin-Leitzinger, Katherine A. Lawson-Michod, Courtney E. Johnson, Irma M. Vlasac, Sean Yoder, Tania Mesa, Dana Roeber, Chad Huff, Michelle A T Hildebrandt, Kristin Haller, Anthony J. Alberg, Elisa V. Bandera, Melissa Bondy, Michele L. Cote, Theresa Hastert, Edward S. Peters, Paul D. Terry, Andrew B. Lawson, Andrew Berchuck, Brooke L. Fridley, Jing-Yi Chern, Jennifer A. Doherty, Jeffrey R. Marks, Joellen M. Schildkraut, Brock C. Christensen, Lucas A. Salas, Lauren C. Peres

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Retrotransposons (REs) constitute nearly half of the genome and include long terminal repeat (LTR) elements, Long INterspersed Elements (LINE), and Short INterspersed Elements (SINE). REs are typically silenced in somatic tissues via DNA methylation but can be reactivated through DNA hypomethylation, potentially impacting gene regulation. Here, we investigate genome-scale profiles of RE methylation in high-grade serous ovarian carcinoma (HGSOC) and associations with survival among Black women.

METHODS: Methylation levels of LTR, LINE-1, and Alu (type of SINE) in 200 HGSOC tumors were predicted using a random forest approach and clustered using multiple consensus algorithms. Associations between RE methylation clusters …

Utilization Of Biomass From Kerai Payung Trees And Waste Paper Through Pyrolysis Technology To Support The Zero-Waste Concept, Anggita Putri Indadari, Nurfa Anisa, Asih Budi Santoso

Journal of Mechanical Engineering Science and Technology (JMEST)

Wisnuwardhana University is a private institution with a green campus environment surrounded by Kerai Payung trees. This environment produces organic waste from trees and inorganic waste such as used paper from campus activities. This study aims to achieve zero-waste processing by using pyrolysis technology to process campus waste, ensuring minimal residue. The experimental method involves comparing waste processing outcomes between conventional combustion and pyrolysis, the data was analyzed by comparing the results of pyrolysis with conventional combustion. The results of biochar from the pyrolysis process of used paper, Kerai Payung leaves, and nagging Kerai Payung tree are 76 g, 250 …

Characterization Of Curcumin As A Coating Material For Polymer-Free Stents Interms Of Morphology And Release, Ameliyana R.S.P.A. Yani, Muhammad Kusumawan Herliansyah

Journal of Mechanical Engineering Science and Technology (JMEST)

The use of bare metal stents over the long term often leads to the re-narrowing of blood vessels, prompting a shift to drug-eluting stents (DES). However, the use of polymers in DES has been known to trigger inflammation and thrombosis in the arteries. As an alternative, polymer-free drug-eluting stents (PF-DES) have emerged as a safer option. In this study, curcumin was selected as the primary coating material for PFDES using the electrophoretic deposition method. The effects of varying curcumin concentrations (125 µg/ml, 250 µg/ml, and 500 µg/ml) were examined to understand their impact on deposition morphology, coating weight, chemical bonding …

Surface Analysis Of Bacterial Cellulose Membrane Made From Biowaste Added With Zno Nanopowder, Naufal Rizky Amasda, Heru Suryanto, Uun Yanuhar, Aminnudin Aminnudin, Fajar Nusantara, Quota Alief Sias

Journal of Mechanical Engineering Science and Technology (JMEST)

Utilization of pineapple biowaste is important to increase the value added to biowaste and solve the environmental problem. So, the study objective is to synthesize membranes of bacterial cellulose made from pineapple biowaste and characterize the surface morphology and porosity of the membrane after being added with ZnO nanopowder. The study starts with extracting biowaste as a bacterial cellulose culture medium for the fermentation process. The obtained pellicle was crushed and homogenized with the added ZnO nanopowder in the presence of ultrasonic waves. The membrane is dried in the oven. The membrane morphology was monitored using scanning electron microscope and …

Logged Out Or Logged In? Stress, Burnout, And Job Satisfaction Between Remote And In-Person Workers, Ryan H. Nguyen

McNair Scholars Research

There is an increasing concern about job-related stress, burnout, and satisfaction. This study explores stress, burnout, and job satisfaction patterns among remote and in-person workers. The sample for this study comprised 88 adults recruited through social media who voluntarily completed a 40-item Google Forms survey. The survey included 10 demographic items and incorporated items from three inventories: Perceived Stress Scale (PSS), Copenhagen Burnout Inventory (CBI), and Aggregate Job Satisfaction Scale (AJSS). The data were analyzed quantitatively using Pearson correlation and independent samples t-tests to assess the relationship among burnout, work-related stress, and job satisfaction, and to determine the influence of …

2021-05-11 Leadership Council Minutes, Susie Salazar

Executive Council Minutes

No abstract provided.

On Expertise Change: The Use And Misuse Of Cultural Evolutionary Models, Ge Fang

Arts & Sciences Graduate Student Theses and Dissertations

Expertise is a major topic in the thoughts of Socrates, Plato, and Aristotle in the West, as well as in the thoughts of Daoist and Buddhist philosophers in the East. Expertise interests ancient philosophers due to the distinctive phenomenology of expertise, the puzzle surrounding the relationship between declarative knowledge and expertise, the practical process of expertise formation, and the use of expertise acquisition as a model for ethical and epistemic development. Philosophical interest in expertise has resurfaced in the last century, particularly regarding the phenomenology of expert performance, the relation between knowledge and expertise, and expertise-based models of ethical and …

Dissecting Macrophage Metabolism In Metabolic Liver Disease, Mandy Mei-Ying Chan

Arts & Sciences Graduate Student Theses and Dissertations

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of chronic liver disease around the globe; however, the mechanisms that lead to the progression of metabolic liver disease are poorly understood. Liver-resident macrophages, known as Kupffer cells (KCs), are the largest population of macrophage in the human body, playing a critical role in immune sensing and tissue homeostasis. In the context of MASLD, KCs undergo cell death through an unclear mechanism, and monocytes enter the liver where they differentiate into macrophages. Next-generation sequencing and spatial-omics studies have revealed significant, heterogeneity in the recruited macrophage populations in both human …

Indirect Genetic Effects Among Neighbors Promote Cooperation And Accelerate Adaptation In A Small-Scale Human Society, Jordan S. Martin, Bret Beheim, Michael Gurven, Hillard Kaplan, Jonathan Stieglitz, Benjamin C. Trumble, Paul Hooper, Daniel K. Cummings, Daniel Eid Rodriguez, Adrian V. Jaeggi

ESI Publications

Explaining the rapid evolution of human cooperation and its role in our species’ biodemographic success remains a major evolutionary puzzle. To address this challenge, we tested a social drive hypothesis, which predicts that social plasticity and social selection in human groups cause indirect genetic effects that accelerate the adaptation of fitness, promoting population growth via feedback between the environmental causes and evolutionary consequences of cooperation. Using Bayesian multilevel models to analyze fertility data from a small-scale society, we demonstrate that density- and frequency-dependent indirect genetic effects on fitness promote the evolution of cooperation among neighboring women, increasing the rate of …

Retrotransposon Methylation Profiles And Survival In Black Women With High-Grade Serous Ovarian Carcinoma, Christelle Colin-Leitzinger, Katherine A Lawson-Michod, Courtney E Johnson, Irma M Vlasac, Sean Yoder, Tania Mesa, Dana Roeber, Chad Huff, Michelle A T Hildebrandt, Kristin Haller, Anthony J Alberg, Elisa V Bandera, Melissa Bondy, Michele L Cote, Theresa Hastert, Edward S Peters, Paul D Terry, Andrew B Lawson, Andrew Berchuck, Brooke L Fridley, Jing-Yi Chern, Jennifer A Doherty, Jeffrey R Marks, Joellen M Schildkraut, Brock C Christensen, Lucas A Salas, Lauren C Peres

Faculty, Staff and Student Publications

Introduction: Retrotransposons (REs) constitute nearly half of the genome and include long terminal repeat (LTR) elements, Long INterspersed Elements (LINE), and Short INterspersed Elements (SINE). REs are typically silenced in somatic tissues via DNA methylation but can be reactivated through DNA hypomethylation, potentially impacting gene regulation. Here, we investigate genome-scale profiles of RE methylation in high-grade serous ovarian carcinoma (HGSOC) and associations with survival among Black women.

Methods: Methylation levels of LTR, LINE-1, and Alu (type of SINE) in 200 HGSOC tumors were predicted using a random forest approach and clustered using multiple consensus algorithms. Associations between RE methylation clusters …

Precision Medicine And Beyond: Evolving Roles Of Targeted Therapy, Immunotherapy, And Artificial Intelligence In Oncology, Linwei Li, Anika Doppalapudi, Jennifer Escamilla, Annu Karithara, Christine Pham, Angel Phillip, Sriya Gullapalli, Lois Baldado, Arjun Bellamkonda, Daniela Gonzalez, Amin Ibrahim, David Sta. Maria, Kaitlyn Ybanez, Hugo Zamarron, Shizue Mito

School of Medicine Publications

Precision medicine in oncology is an evolving therapeutic approach that leverages genetic, clinical, and biomarker data to tailor treatments to individual patients. This review explores the three core pillars of modern precision oncology: targeted therapy, immunotherapy, and the integration of artificial intelligence (AI) into clinical practice. Targeted therapies, including monoclonal antibodies and antibody-drug conjugates, selectively inhibit molecular pathways involved in tumor growth. While conventional chemotherapy remains the backbone of treatment and has improved remission rates, its cytotoxic nature limits broader applicability and increases the risk of comorbidities. Immunotherapies, particularly immune checkpoint inhibitors and chimeric antigen receptor T-cell therapies, have transformed …

Dosimetric Comparisons Of 6mv, 6fff, 10mv, And 10fff On Vmat Planning In Patients With Endometrial Cancer, Madisin M. Depas

Masters Projects

Purpose: This study aimed to evaluate the dosimetric and efficiency impacts of different photon beam energies—6MV, 6 flattening filter free (FFF), 10MV, and 10FFF—on volumetric modulated arc therapy (VMAT) plans for endometrial cancer, with attention to target coverage, organ at risk (OAR) sparing, and treatment efficiency.

Methods: A retrospective analysis was conducted on 25 patients with post-hysterectomy endometrial cancer. Each patient received four VMAT plans with varying energies. Planning metrics assessed included planning target volume (PTV) dose maximum (Dmax), conformity index (CI), heterogeneity index (HI), OAR doses (bladder, bowel, rectum), and total monitor units (MU). Correlations were drawn …

Investigation Into Intraocular Pressure Distribution Via Computer Aided Engineering (Cae), Madison Maureen Hinman

Masters Theses

The leading cause for irreversible blindness and vision loss is glaucoma - an eye condition associated with elevated intraocular pressure (IOP). Increased IOP is also seen during other pathological conditions like spaceflight-associated neuro-ocular syndrome (SANS), and non-pathological conditions as when playing a wind instrument. The study aimed to describe the influence of different vitreous cavity size as well as vitreous fluid viscosity on the IOP as measured at the back of the eye on the retina. Improved understanding of eye pressure transmission can aid in a better understanding of eye diseases. The experiment conducted included cavities of varying size and …

Gene Regulatory Network Prediction Using Machine Learning, Deep Learning, And Hybrid Approaches, Sai Teja Mummadi, Md Khairul Islam, Victor Busov, Hairong Wei

Michigan Tech Publications

Construction of gene regulatory networks (GRNs) is essential for elucidating the regulatory mechanisms underlying metabolic pathways, biological processes, and complex traits. In this study, we developed and evaluated machine learning, deep learning, and hybrid approaches for constructing GRNs by integrating prior knowledge and large-scale transcriptomic data from Arabidopsis thaliana, poplar, and maize. Among these, hybrid models that combined convolutional neural networks and machine learning consistently outperformed traditional machine learning and statistical methods, achieving over 95% accuracy on the holdout test datasets. These models not only identified a greater number of known transcription factors regulating the lignin biosynthesis pathway but also …

The Problem With Consumer Affordability Of Prescription Medications In The United States, Valerie E. Bell

Walden Dissertations and Doctoral Studies

Consumer affordability of prescription drugs is an ongoing problem in the United States. This study was undertaken to research the financial, physical, and economic effects of drug prices on consumers and the methods used by consumers to address such effects. Rational choice and power and politics theories were used to explain the decisions consumers make when they could not afford their medications and the role policies and politics play in drug pricing. The research questions concerned the relationship between consumers’ perceptions of drug pricing and their ability to purchase medications. The quantitative nonexperimental study involved the administration of a survey …

Fathers’ Experiences With Reunification With The Massachusetts Child Welfare System, Phernel Joseph Manigat

Walden Dissertations and Doctoral Studies

This study focused on fathers’ experiences with the Massachusetts child welfare system (MCWS) or the Department of Children and Families (DCF) during the reunification process with their children, particularly those fathers who received sole custody of their children during this process. Researchers have demonstrated that fathers are minimally engaged and mostly ignored in the child welfare system (CWS). A research gap was identified regarding the experiences of fathers who received sole custody of their children through the CWS. The purpose of this study was to explore these fathers’ experiences with the MCWS or the DCF during the reunification process with …

Data-Driven Approach To Dynamic Resting State Functional Connectivity In Post-Traumatic Stress Disorder: An Enigma-Pgc Ptsd Study, Jacklynn M. Fitzgerald

Psychology Faculty Research and Publications

Using functional magnetic resonance imaging (fMRI), symptoms of posttraumatic stress disorder (PTSD) have been associated with aberrations in brain networks in the absence of a given cognitive demand or task, called resting-state networks. Prior work has focused on disruption in the static functional connectivity (FC) among specific regions constrained by a priori hypotheses. However, dynamic FC, an approach that examines brain network characteristics over time, may provide a more sensitive measure to understand the network properties underlying dysfunction in PTSD. Further, using a data-driven analytic approach may reveal the contribution of other larger network disturbances beyond those revealed by hypothesis-driven …

In Vitro Α-Glucosidase Enzyme Inhibition Activity Test Of Water Extract From Sintok (Cinnamomum Sintoc Blume) Bark, Astrella Amanda Putri Saksono, Inana Ratu Soripada Simanjuntak, Mariana Wahjudi, Marisca Evalina Gondokesumo

Pharmaceutical Sciences and Research

Diabetes mellitus is a condition characterized by elevated blood glucose levels beyond the normal limits. One therapeutic approach for managing diabetes mellitus involves inhibiting the α-glucosidase enzyme, which plays a role in glucose absorption in the body. However, the use of oral antidiabetic drugs from the α-glucosidase inhibitor class often causes gastrointestinal side effects. Therefore, exploring natural materials as alternative treatments is a promising option. In Indonesia, one plant with potential as an alternative treatment is sintok (Cinnamomum sintoc Blume), a member of the Cinnamomum genus, which is widely utilized in traditional medicine for chronic diseases such as …

Gastroprotective Potential Of Medicinal Plant From Central Kalimantan: Sungkai Leaves (Peronema Canescens Jack)-Ultrasonic Assisted Extraction In Rats Induced With Absolute Ethanol, Dilasari Savitri, Elsa Trinovita, Ratna Widayati, Septi Handayani, Sintha Nugrahini

Pharmaceutical Sciences and Research

Peptic ulcer disease is a gastrointestinal disorder associated with significant morbidity and mortality. Enhancing the quality of life of patients with peptic ulcers often involves integrating conventional treatments with complementary alternative therapies. One such alternative therapy is herbal remedies, which local communities have long recognized. Sungkai leaves (Peronema canescens Jack) contain various bioactive components, including flavonoids, alkaloids, saponins, tannins, steroids, and phenolic compounds. This study aimed to assess the gastroprotective properties of sungkai leaf extract (Peronema canescens Jack) by analyzing the average size of gastric lesions in male Wistar rats exposed to absolute ethanol. The research used a …

Systematic Review Of Parkinsonism In Cerebrotendinous Xanthomatosis, Jennifer Hanson, Penelope E Bonnen

Faculty, Staff and Students Publications

Background: Cerebrotendinous Xanthomatosis (CTX) is a rare, inherited metabolic disease caused by pathogenic variants in CYP27A1. The clinical presentation of this progressive disease includes cognitive deficits, ataxia, peripheral neuropathy, and pyramidal signs, as well as bilateral cataracts and tendon xanthomas. In some cases, CTX also includes parkinsonism. The goals of this study are to develop a data source that provides improved characterization and awareness of parkinsonism in CTX.

Methods: We conducted a systematic review of the literature according to PRISMA guidelines to identify all published individuals diagnosed with CTX and parkinsonism. Clinical signs, imaging findings and treatment response to …

Integrating Circulating Tumor Dna Into Clinical Management Of Colorectal Cancer: Practical Implications And Therapeutic Challenges, Nikhil Vojjala, Viktoriya Gibatova, Raj N Shah, Sakshi Singal, Rishab Prabhu, Geetha Krishnamoorthy, Karen Riggins, Nagaishwarya Moka

Faculty, Staff and Students Publications

The American Cancer Society estimates that over 152,000 new cases of colorectal cancer (CRC) were diagnosed in 2024, with more than 105,000 cases affecting the colon and 46,000 involving the rectum. CRC remains the second leading cause of cancer-related deaths in the United States, with an estimated 53,010 deaths in 2024. In the era of precision medicine, which incorporates molecular and environmental information into clinical decision-making, identifying patients harboring a deficiency in Deoxyribonucleic acid (DNA) repair allowed for targeted immunotherapies and significantly reduced CRC-related mortality. A significant advancement in this domain is the application of liquid biopsy, which has emerged …

Examining Light-Circadian Interactions In Regulation Of Amyloid Plaque Pathology, Melvin William King

Arts & Sciences Graduate Student Theses and Dissertations

Circadian disruption has long been appreciated as a downstream consequence of Alzheimer’s Disease in humans. However, an upstream role for circadian disruption in regulating AD pathology remains an open question. The mammalian circadian system is hierarchical, with cellular clocks – driven largely by BMAL1 – synchronized by the hypothalamic SCN (suprachiasmatic nucleus) via a combination of hormonal and synaptic cues. To assess the relative contributions of each component to Alzheimer’s Disease pathology, we crossed mice harboring either microglial (Cx3cr1/Lyz2-Cre) or GABAergic (VGAT-iCre, expressed in more than 95% of the SCN) BMAL1-knockout to mouse models of Aβ aggregation (5xFAD; APP/PS1-21), which …

Collection Of Instructional Slides From Molten Salt Electrochemistry Symposium (Moses), Devin Rappleye, Carlos Mejia

Faculty Publications

During the Molten Salt Electrochemistry Symposium (MoSES) on July 30-31, 2025, interactive instruction was given to the attendees including live demonstrations. These slides contain the introductory instructions given for each learning module at MoSES 2025. Please visit https://pyro.byu.edu/moses for more information.

Unveiling Spatial Heterogeneity In Medulloblastoma: A Multi-Omics Analysis Of Cellular State And Geographical Organization, Jiankang Li, Hailong Liu, Ziwei Wang, Jiao Zhang, Xuan Chen, Craig Daniels, Xiaochong Wu, Olivier Saulnier, Hiromichi Suzuki, Pasqualino De Antonellis, Alexandra Rasnitsyn, Winnie Ong, Evan Y Wang, Liam D Hendrikse, Yu Su, Yu Tian, Dongming Han, Ruohan Wang, Jialin Mo, Fei Liu, Kaiwen Deng, Dongyang Wang, Zhaoyang Feng, Yifei Jiang, Yanong Li, Yuting Ma, Zijia Liu, Meiyu Li, Peiyi Tian, Yanfeng Shi, Yong Jiang, Tao Yang, Shouwei Li, Jianfeng Liang, Jingchuan Wu, Ying Wang, Wanjing Zou, Yina Jiang, Lusheng Wang, Fang Chen, Xin Jin, Shuaicheng Li, Xiaoguang Qiu, Chunde Li, Ya Gao, Yujie Tang, Michael D Taylor, Tao Jiang

Faculty, Staff and Students Publications

Background: Despite numerous studies on medulloblastoma (MB) cell heterogeneity, the spatial characteristics of cellular states remain unclear.

Methods: We analyze single-nucleus and spatial transcriptomes and chromatin accessibility from human MB spanning four subgroups, to identify malignant cell populations and describe the spatial evolutionary trajectories. The spatial copy number variations (CNVs) patterns and niches were analyzed to investigate the cellular interactions.

Results: Three main malignant cell populations were identified, including progenitor-like, cycling, and differentiated populations. Gene signatures of cell populations strongly correlate to clinical outcomes. These tumor cell populations are geographically organized as stem-like and mature regions, highlighting their spatially heterogeneous …