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2025

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Evaluation Of Impact Of Some Epidemiologic Factors On The Bronchiolitis Caused By Respiratory Syncytial Virus (Rsv) In Infants And Young Children Under 5 Years Old In Al- Diwaniyah Province, Rajaa Abd Hamaadi Chaloob, Wissam Salih Abood Dec 2025

Evaluation Of Impact Of Some Epidemiologic Factors On The Bronchiolitis Caused By Respiratory Syncytial Virus (Rsv) In Infants And Young Children Under 5 Years Old In Al- Diwaniyah Province, Rajaa Abd Hamaadi Chaloob, Wissam Salih Abood

Al-Qadisiyah Medical Journal

Background:. The biggest viral cause of bronchiolitis and one of the major agents behind respiratory-tract infections globally is the Human Respiratory Syncytial Virus (HRSV). RSV is transmitted through airborne droplets or close contact with contaminated objects. Objective: The purpose of this research is to detect major risk factors associated with susceptibility to and severity of bronchiolitis in infants and young children under the age of five caused by respiratory syncytial virus (RSV).  study design to detect antibodies Immunoglobulin M (IgM) for human RSV in serum samples by using specific enzyme-linked immunosorbent assay (ELISA) kits as a diagnostic test Methods: This …


Environmental Science And Sustainable Development: Behavioral Transformation To Knowledge System Integration For Sustainability Action, Ahyahudin Sodri, Herdis Herdiansyah Dec 2025

Environmental Science And Sustainable Development: Behavioral Transformation To Knowledge System Integration For Sustainability Action, Ahyahudin Sodri, Herdis Herdiansyah

Journal of Environmental Science and Sustainable Development

Sustainability issues are now a global concern. However, knowing the root causes of problems and the target is not the only factor that constantly motivates change for the better (Wamsle & Osberg, 2022) as such change also requires encouragement from actors, including individuals, organizations, and communities. Therefore, the human aspect is crucial for the successful achievement of sustainability (Hariram et al., 2023). In other words, questions on sustainability are not just about "what should be done?" and also on “how to get people to do it?” and “why are currently available interventions not yet fully utilized?” …


The Effect Of Withering Methods On Physicochemical And Sensory Properties Of Liberica Coffee Leaf Tea (Coffea Liberica), Surhaini Surhaini, Indriyani Indriyani, Rahayu Suseno, Rinaldi Rinaldi, Ferry Jie, Huda Wazzan Dec 2025

The Effect Of Withering Methods On Physicochemical And Sensory Properties Of Liberica Coffee Leaf Tea (Coffea Liberica), Surhaini Surhaini, Indriyani Indriyani, Rahayu Suseno, Rinaldi Rinaldi, Ferry Jie, Huda Wazzan

Research outputs 2022 to 2026

This study aims to evaluate the effect of different withering methods on physicochemical and organoleptic properties of Liberica coffee leaf tea (Coffea liberica) and to identify the optimal treatment. The experiment was conducted using a Completely Randomized Design (CRD) with five withering treatments, including no withering, room temperature withering for 10 h, air withering for 10 h, oven withering at 60°C for 30 min, and steaming for 2 min, each with four replications. The observed parameters included powder moisture content, pH, color (L*, a*, b*), antioxidant activity, total phenols, total tannins, flavonoids, and sensory attributes, namely color, aroma, acidity, taste, …


The Sensus Communis And Religion In John Hughes’ The Siege Of Damascus (1719), David Alvarez Dec 2025

The Sensus Communis And Religion In John Hughes’ The Siege Of Damascus (1719), David Alvarez

English Faculty publications

John Hughes’ tragedy The Siege of Damascus (1720) seeks to bridge the divide between east and west, between Islam and Christianity, by advancing an understanding of a sensus communis in terms of sympathy, honor, and mutual respect. I argue that this articulation of a sensus communis relies on how the play conceptualizes ‘genuine religion’ in global terms. It does this primarily by universalizing the project of Anglican clergy to champion Christianity as a civil religion. The play thus points to the importance of enlightenment efforts to reconceptualize religion for a genealogy of the sensus communis.


Seadyck Realty Co., Llc V. State Of New York Division Of Housing & Community Renewal Dec 2025

Seadyck Realty Co., Llc V. State Of New York Division Of Housing & Community Renewal

All Decisions

A landlord challenged a DHCR order that reversed a Rent Administrator's decision, invalidating individual apartment improvements (IAIs) due to an alleged identity of interest between the owner and the contractor. The court, in an Article 78 proceeding, found that DHCR's policy statement did not automatically mandate complete invalidation of IAIs based solely on an identity of interest. Instead, it suggested requesting additional proof and disallowing only unsubstantiated costs. The court remanded the case to the Rent Administrator for a new determination, directing scrutiny of the work performed and its value, rather than a blanket disallowance of the rent increase.


Native-Speakerism And Multilingual Student Anxiety In One-To-One Mentoring, Grace Lee-Amuzie Dec 2025

Native-Speakerism And Multilingual Student Anxiety In One-To-One Mentoring, Grace Lee-Amuzie

The Writing Center Journal

While one-to- one writing tutoring is often viewed as a supportive space for student writers, it can also reproduce racialized linguistic hierarchies that exacerbate anxiety for multilingual students. This article examines second language (L2) anxiety as a structurally induced emotional response to native-speakerism— the ideology that privileges white, Anglophone, native English speakers as the standard for language competence. Drawing from L2 anxiety research in applied linguistics and writing center studies, the article explores how native-speakerism influences multilingual students’ self-perception, interaction, and performance in L2 during one-to- one tutoring. It discusses the sources and dimensions of L2 anxiety across all four …


Back Matter Dec 2025

Back Matter

The Writing Center Journal

Back Matter for Writing Center Journal 43.3.(2025)


Ai Ethics And Governance For Leaders In Higher Education: A Hermeneutic Phenomenology Of Faculty Early Adopters’ Sensemaking, Pedagogical Innovation, And Transformation, Freddie Seba Dec 2025

Ai Ethics And Governance For Leaders In Higher Education: A Hermeneutic Phenomenology Of Faculty Early Adopters’ Sensemaking, Pedagogical Innovation, And Transformation, Freddie Seba

Doctoral Dissertations

Artificial Intelligence (AI), especially Generative AI (GenAI), is transforming how we work, learn, acquire, produce, and deliver knowledge, as higher education experiences existential pressures, including demographic changes that reduce enrollment and revenues, as well as shifting public and government perceptions of higher education's value.

This hermeneutic phenomenology dissertation study explores how faculty early adopters critically engage, innovate, and experiment with this nascent transformational technology in their pedagogies amid multilevel pressures: macro—market-driven (neoliberalism) logic, Big Tech, and demographic change; meso—institutional policy, broader faculty community, and pedagogical innovation; micro—widespread student adoption, pedagogical experimentation, and innovation.

This dissertation study centers on shifting AI …


Applications Of Artificial Intelligence In Dental Malocclusion: A Scoping Review Of Recent Advances (2020-2025), Man Hung, Owen Cohen, Nicholas Beasley, Cairo Ziebarth, Connor Schwartz, Alicia Parry, Martin S. Lipsky Dec 2025

Applications Of Artificial Intelligence In Dental Malocclusion: A Scoping Review Of Recent Advances (2020-2025), Man Hung, Owen Cohen, Nicholas Beasley, Cairo Ziebarth, Connor Schwartz, Alicia Parry, Martin S. Lipsky

Institute on Aging Publications

Introduction:

Dental malocclusion affects more than half of the global population, causing significant functional and esthetic consequences. The integration of artificial intelligence (AI) into orthodontic care for malocclusion has the potential to enhance diagnostic accuracy, treatment planning, and clinical efficiency. However, existing research remains fragmented, and recent advances have not been comprehensively synthesized. This scoping review aimed to map the current landscape of AI applications in dental malocclusion from 2020 to 2025. Methods: The review followed the Joanna Briggs Institute methodology and the PRISMA-ScR guidelines. The authors conducted a systematic search across four databases (PubMed, Scopus, Web of Science, and …


Family Dementia Caregivers’ Disaster Preparedness In Chinese American Communities In New York City, Weiyu Mao, Bei Wu, Yaolin Pei, Zhen Cong Dec 2025

Family Dementia Caregivers’ Disaster Preparedness In Chinese American Communities In New York City, Weiyu Mao, Bei Wu, Yaolin Pei, Zhen Cong

Health Sciences and Kinesiology Faculty Articles

Disaster preparedness is a significant public health concern. Disasters manifest in different forms and often lead to disruption of daily life. This is especially challenging for family dementia caregivers and their care recipients in the community. There remains much unknown regarding dementia caregiver disaster preparedness, especially in ethnic and racial communities. Guided by Protection Motivation Theory, with the backdrop of Hurricane Ida, this study explored the association between caregiving-related characteristics, cognitive appraisals, and disaster preparedness among caregivers in Chinese American communities. Data came from a pilot study on Chinese American family dementia caregivers in New York City between November 2021 …


Gut Microbiome Metagenomics In Clinical Practice: Bridging The Gap Between Research And Precision Medicine, Henok Ayalew Tegegne, Tor C Savidge Dec 2025

Gut Microbiome Metagenomics In Clinical Practice: Bridging The Gap Between Research And Precision Medicine, Henok Ayalew Tegegne, Tor C Savidge

Faculty, Staff and Students Publications

Gut microbiome metagenomics is emerging as a cornerstone of precision medicine, offering exceptional opportunities for improved diagnostics, risk stratification, and therapeutic development. Advances in high-throughput sequencing have uncovered robust microbial signatures linked to infectious, inflammatory, metabolic, and neoplastic diseases. Clinical applications now include pathogen detection, antimicrobial resistance profiling, microbiota-based therapies, and enterotype-guided patient stratification. However, translation into routine care is hindered by significant barriers including methodological variability, limited functional annotation, lack of bioinformatics standardization, and underrepresentation of global populations. This review synthesizes current translational strategies, emphasizing the need for hypothesis-driven designs, multi-omic integration, longitudinal and multi-center cohorts, and mechanistic validation. …


Coolies Of Shimla: Modern Slavery As Relic Of The British Raj, Priya Kapoor Dec 2025

Coolies Of Shimla: Modern Slavery As Relic Of The British Raj, Priya Kapoor

Politics and Global Affairs Faculty Publications and Presentations

Coolie labor needs to be understood as a contemporary transnational practice rooted in local practices of feudal kings and the British Empire. When the British Raj established Shimla as its summer capital in 1864, they did not eliminate archaic labor practices; instead, they cleverly modified them to serve the Empire’s infrastructural needs. Under the guise of reform, the British introduced nominal pay to bypass anti-slavery laws, effectively rebranding the forced laborer as the "coolie"—a racialized linguistic construct that signified a state of permanent subalternity. This labor force was the veritable backbone of the Raj, manually carving the treacherous Hindustan-Tibet Road …


Us Drug Policy Does Not Align With Experts’ Rankings Of Drug Harms: A Multi-Criteria Decision Analysis, Michael Broman, Alan K Davis, Stacey Armstrong, Adam Levin, Kaltum Ahmed, Gustavo A Angarita, Brooke J Arterberry, Cecilia Bergeria, Mitch Earleywine, Kathryn S Gex, Tom Gregoire, Jamey J Lister, David S Mathai, Nicky J Mehtani, Nathan Menke, Charles D Nichols, Hillary Shaub, Alayna P Tackett, Brandon Weiss, Nefize Yalin, Lawrence D Phillips Dec 2025

Us Drug Policy Does Not Align With Experts’ Rankings Of Drug Harms: A Multi-Criteria Decision Analysis, Michael Broman, Alan K Davis, Stacey Armstrong, Adam Levin, Kaltum Ahmed, Gustavo A Angarita, Brooke J Arterberry, Cecilia Bergeria, Mitch Earleywine, Kathryn S Gex, Tom Gregoire, Jamey J Lister, David S Mathai, Nicky J Mehtani, Nathan Menke, Charles D Nichols, Hillary Shaub, Alayna P Tackett, Brandon Weiss, Nefize Yalin, Lawrence D Phillips

Faculty, Staff and Students Publications

Background: United States drug policy is primarily based on the Controlled Substances Act of 1970 and largely contradicts scientific evidence about how to mitigate drugs’ harms. Expert consensus on drug harms could inform policy that improves the health of people who use drugs while reducing negative societal impacts of drug use. Therefore, this study adapted and extended the relevant 2010 United Kingdom multi-criteria decision analysis, rating drug harms by criteria comprising health and social impacts to people who use drugs and their families, communities, and society.

Methods: Seventeen experts on drug use in the US, including three with lived experience …


Nutrition Support Adequacy In Children With Biliary Atresia After Liver Transplant, Nicole Knebusch, Manpreet Virk, Moreshwar S Desai, Marwa Mansour, Stacey Beer, Brittany Pearo, Kelby Fuller, Krupa Mysore, John Goss, Thomas Fogarty, Fernando Stein, Jorge A Coss-Bu Dec 2025

Nutrition Support Adequacy In Children With Biliary Atresia After Liver Transplant, Nicole Knebusch, Manpreet Virk, Moreshwar S Desai, Marwa Mansour, Stacey Beer, Brittany Pearo, Kelby Fuller, Krupa Mysore, John Goss, Thomas Fogarty, Fernando Stein, Jorge A Coss-Bu

Faculty, Staff and Students Publications

No abstract provided.


Going Nuclear: Exploring Mtor’S Transcriptional Role In Regulating Estrogen Receptor Positive Breast Cancer, Alek S. Torres Dec 2025

Going Nuclear: Exploring Mtor’S Transcriptional Role In Regulating Estrogen Receptor Positive Breast Cancer, Alek S. Torres

NYMC Student Theses and Dissertations

Global changes in gene expression are orchestrated by an array of transcription factors regulated by both extracellular and intracellular signals. The mechanistic target of rapamycin (mTOR) is a protein kinase that ubiquitously mediates signaling networks across every cell type, in two active complexes, mTORC1 and mTORC2. By phosphorylating its downstream targets, these classically cytosolic complexes regulate protein homeostasis, metabolism, cell growth, proliferation and survival. However, evidence from prostate cancer studies reveals mTOR and its partners can occupy the nucleus, where its interaction with chromatin (in complex with transcription factors) has been shown to regulate gene expression at the level of …


Job Stress And Organizational Resources As Predictors Of Teachers Psychological Well-Being: A Jd–R-Based Study In Semarang, Yuliani Setyaningsih, Ida Wahyuni, Ekawati Ekawati, Dina Lusiana Setyowati, Risa Septi Astutik Dec 2025

Job Stress And Organizational Resources As Predictors Of Teachers Psychological Well-Being: A Jd–R-Based Study In Semarang, Yuliani Setyaningsih, Ida Wahyuni, Ekawati Ekawati, Dina Lusiana Setyowati, Risa Septi Astutik

Media Kesehatan Masyarakat Indonesia

Teacher Psychological Well-Being (PWB) is increasingly recognized as vital to educational effectiveness, yet empirical studies in low and middle-income countries remain limited. This study investigates the predictors of PWB among senior high school teachers in Semarang, Indonesia, using the Job Demands–Resources (JD–R) model. A cross-sectional analytic design was employed, involving all 290 teachers from six public schools. Data were collected through validated questionnaires measuring job stress, organizational climate, career development, working conditions, and well-being, alongside demographic variables. Descriptive statistics, Spearman correlations, and multivariate logistic regression were used to analyze the data. Results showed that over half of the participants experienced …


Strengthening Community-Based Ncd Prevention Through Service Quality And Availability: Lessons From Banjarmasin City, Ayu Riana Sari Azwari, Adi Nugroho, Rosihan Adhani, Acim Heri Iswanto, Muhammad Abdan Shadiqi, Herawati Herawati, Meitria Syahadatina Noor, M. Ramadhan Dec 2025

Strengthening Community-Based Ncd Prevention Through Service Quality And Availability: Lessons From Banjarmasin City, Ayu Riana Sari Azwari, Adi Nugroho, Rosihan Adhani, Acim Heri Iswanto, Muhammad Abdan Shadiqi, Herawati Herawati, Meitria Syahadatina Noor, M. Ramadhan

Media Kesehatan Masyarakat Indonesia

The main cause of death both globally and nationally is Non-Communicable Diseases (NCDs). Integrated Non-Communicable Disease Posts (INCDs Posts) play a crucial role in early detection and control of NCD risk factors at the community acceptance of INCDs Posts services. This study aims to analyse the influence of accessibility, availability, and services on community acceptance of INCD Posts in Banjarmasin City. A cross-sectional design was used, with data analysed using Partial Least Squares-Structural Equation Modelling (PLS-SEM) on 654 respondents. The variables analysed included accessibility, availability, quality, and community acceptance of INCDs Post services. The results of the study indicate that …


Prevalence And Risk Factors And Efforts To Reduce Dengue Fever And Dengue Hemorrhagic Fever Infections At Pku Muhammadiyah Gamping Hospital, Yogyakarta, Kusbaryanto Kusbaryanto, Abdurrasyid Bin Abdurrahman, Ekorini Listiowati, Yusuf Alam Romadhon, Aisyah Rosyida Dec 2025

Prevalence And Risk Factors And Efforts To Reduce Dengue Fever And Dengue Hemorrhagic Fever Infections At Pku Muhammadiyah Gamping Hospital, Yogyakarta, Kusbaryanto Kusbaryanto, Abdurrasyid Bin Abdurrahman, Ekorini Listiowati, Yusuf Alam Romadhon, Aisyah Rosyida

Media Kesehatan Masyarakat Indonesia

The incidence of Dengue Fever (DF) and Dengue Hemorrhagic Fever (DHF) has increased sharply in recent decades, making these infections endemic in several parts of the world. The purpose of this study was to analyze the prevalence, risk factors, and efforts to reduce DF and DHF infections at PKU Muhammadiyah Gamping Hospital, Yogyakarta. This study employed an observational cross-sectional design. The study sample consisted of patients diagnosed with DF or DHF at general hospitals in Yogyakarta between January 2019 and December 2023 who met the inclusion and exclusion criteria. Patients with a DF or DHF diagnosis but incomplete data were …


The Effects Of Consumption Habits Of Vegetables Rich In Galactagogue On Breastfeeding Intensity, Nurul Fadhilah, Mohammad Zen Rahfiludin, Daru Lestantyo, Sri Winarni Dec 2025

The Effects Of Consumption Habits Of Vegetables Rich In Galactagogue On Breastfeeding Intensity, Nurul Fadhilah, Mohammad Zen Rahfiludin, Daru Lestantyo, Sri Winarni

Media Kesehatan Masyarakat Indonesia

Providing breast milk to babies becomes one of the keys to growth and development. Breast milk contains various crucial nutrients needed for the growth and development period of babies. To analyze the effect of consuming local vegetables containing galactagogues on breastfeeding intensity. This study was a cross-sectional study conducted at 38 Community Health Centers in Tasikmalaya Regency in 2024. The population was 5971 people. The sampling technique is proportional sampling. The study sample was 450 breastfeeding mothers. The independent variables were consumption behaviros of galactagogue vegetables, such as katuk leaves, moringa, spinach, young papaya, and banana blossoms. The dependent variable …


Personalized Postpartum Interventions And Their Impact On Working Mothers, Mey Elisa Safitri, Aniza Abd. Aziz, Nurulhuda Mat Hassan Dec 2025

Personalized Postpartum Interventions And Their Impact On Working Mothers, Mey Elisa Safitri, Aniza Abd. Aziz, Nurulhuda Mat Hassan

Media Kesehatan Masyarakat Indonesia

Exclusive breastfeeding is a critical determinant in maintaining infant health and nutritional status. However, its coverage remains low, particularly among postpartum working mothers. Limited maternal knowledge, lack of family especially spousal support, and low maternal satisfaction are reported key factors contributing to suboptimal breastfeeding practices. This quasi-experimental study employed a non-equivalent control group pre-test and post-test design. It was conducted from January to October 2024 in the working area of the Darussalam Primary Health Center in Medan, Indonesia. A total of 140 postpartum working mothers were purposively selected and divided into two groups: intervention (n=70) and control (n=70). The intervention …


Developing The Community Outreach Effectiveness Model (Coem) For Hiv Prevention Among Key Populations In Indonesia: Evidence From The Ibbs, Lely Wahyuniar, Aang Sutrisna, Dimas Budi Wicaksana, Rizky Habsi Dec 2025

Developing The Community Outreach Effectiveness Model (Coem) For Hiv Prevention Among Key Populations In Indonesia: Evidence From The Ibbs, Lely Wahyuniar, Aang Sutrisna, Dimas Budi Wicaksana, Rizky Habsi

Media Kesehatan Masyarakat Indonesia

Indonesia continues to experience a concentrated HIV epidemic, with key populations female sex workers, men who have sex with men, transgender women, and people who inject drugs bearing a disproportionate burden, while uptake of HIV prevention services and sustained behavior change remain inadequate. Community outreach has been widely implemented to address these gaps; however, its effectiveness has not been comprehensively documented at the national level. This study aimed to assess the impact of community outreach interventions on HIV prevention uptake and behavioral outcomes among key populations in Indonesia using the Community Outreach Effectiveness Model (COEM). A quantitative retrospective study was …


Optimising Drugs And Vaccines Management Utilizing 5 M Method: The Case Of Riau Islands, Indonesia, Erwin Sutejo, Yosi Irawati Wibowo, Indri Ayu Ningsih, Bruce Sunderland, Adji Prayitno Setiadi Dec 2025

Optimising Drugs And Vaccines Management Utilizing 5 M Method: The Case Of Riau Islands, Indonesia, Erwin Sutejo, Yosi Irawati Wibowo, Indri Ayu Ningsih, Bruce Sunderland, Adji Prayitno Setiadi

Media Kesehatan Masyarakat Indonesia

A resilient health system should include the ability to access essential drugs and vaccines in all locations. This study aims to perform root cause analysis and develop recommendations to optimize drugs and vaccines management for Riau Islands Province, Indonesia. This study used qualitative approaches which included interviews and group discussions with key stakeholders (n=6) as well as an expert panel (n=4). Data on the underlying causes of problems and recommendations were structured into 5M (Man, Money, Machine, Method, Material). Problems related to Man (limited human resources) were identified for most management stages. Other problems reported: Planning – Money (inefficient budget …


Factors Associated With Coexisting Forms Of Malnutrition (Stunting And Wasting) In Under-Five In Southeast Sulawesi, Aisyah Nurul Hidayah, Suyatno Suyatno, Apoina Kartini Dec 2025

Factors Associated With Coexisting Forms Of Malnutrition (Stunting And Wasting) In Under-Five In Southeast Sulawesi, Aisyah Nurul Hidayah, Suyatno Suyatno, Apoina Kartini

Media Kesehatan Masyarakat Indonesia

The presence of more than one type of nutritional disorder in a person's body is called Coexisting Forms of Malnutrition (CFM). Children with CFM, such as those experiencing stunting, wasting, and underweight, 12.3 fold risk of death (CI=7.67-19.28) compared to healthy children. Southeast Sulawesi has the tenth highest prevalence of these cases. This study used secondary data based on the Indonesian Nutrition Status Survey (SSGI) 2022 with a cross-sectional design using complex sample analysis. The sample was children under five from Southeast Sulawesi Province, with a final sample size of 8,518 children analyzed. The median age of the sample was …


Evaluation Of Anthropometric Data Quality For Children From Electronic-Based Nutrition Surveillance: A Case Study In Magelang Regency, Central Java, Indonesia, Slamet Riyanto, Digna Niken Purwaningrum, Lutfan Lazuardi Dec 2025

Evaluation Of Anthropometric Data Quality For Children From Electronic-Based Nutrition Surveillance: A Case Study In Magelang Regency, Central Java, Indonesia, Slamet Riyanto, Digna Niken Purwaningrum, Lutfan Lazuardi

Media Kesehatan Masyarakat Indonesia

Data quality regarding the nutritional status of children under five is crucial for developing strategies to address nutritional issues. This study aims to develop indicators and assess the quality of anthropometric data from community-based nutrition surveillance using the EPPGBM application in Magelang Regency. The research employed an observational design with a quantitative approach. Data quality indicators were defined based on expert consensus using the Delphi method. These indicators were also used to construct an anthropometric data quality index (IKDA). The WPS Office spreadsheet was utilized to assess data quality and perform IKDA calculations. Nine data quality indicators were identified, categorized …


Eata Mediated Degradation Of Intestinal Mucus Is Species-Specific And Driven By Muc2 Structural Features, Sergio Trillo-Muyo, Brendan Dolan, Frida Svensson, Tim J Vickers, Liisa Arike, Maria-Jose García-Bonete, Jenny K Gustafsson, Mathias I Nielsen, Hans H Wandall, James M Fleckenstein, Gunnar C Hansson, Sjoerd Van Der Post Dec 2025

Eata Mediated Degradation Of Intestinal Mucus Is Species-Specific And Driven By Muc2 Structural Features, Sergio Trillo-Muyo, Brendan Dolan, Frida Svensson, Tim J Vickers, Liisa Arike, Maria-Jose García-Bonete, Jenny K Gustafsson, Mathias I Nielsen, Hans H Wandall, James M Fleckenstein, Gunnar C Hansson, Sjoerd Van Der Post

2020-Current year OA Pubs

Enterotoxigenic Escherichia coli (ETEC) infections are a leading cause of diarrheal illness, responsible for an estimated 100,000 deaths annually. ETEC pathogenesis is driven by various virulence factors, including toxins, adhesins, and noncanonical factors such as the protease EatA. The first line of host defense against intestinal pathogenic bacterial infections is the protective intestinal mucus layer. Here, we demonstrate the mechanism by which EatA degrades the core mucus component MUC2, thereby facilitating access to the epithelial cell surface and promoting infection. We identify the specific cleavage site region localized at the C-terminal of MUC2. EatA's protease activity depends on the interaction …


Membrane Il-18 Identifies A Human Macrophage Subset With Distinct Proteomic And Functional Traits, Chiara Vitale, Marco Colonna, Et Al. Dec 2025

Membrane Il-18 Identifies A Human Macrophage Subset With Distinct Proteomic And Functional Traits, Chiara Vitale, Marco Colonna, Et Al.

2020-Current year OA Pubs

This study contributes to the characterization of human macrophages in normal and pathological conditions such as cancer. We characterized a macrophage population expressing membrane-associated IL-18 (mIL-18) that shows peculiar proteomic, phenotypic, ultrastructural, and functional properties. mIL-18+ macrophages exhibit increased levels of key proteins involved in pathogen recognition, activation, migration, and endocytosis. They also display specialized functions in vesicle and actin filament transport and lipid metabolism, and have typical mitochondrial traits. Importantly, mIL-18+ cells dominate the peritoneal fluid of adult cancer patients and are present in the bone marrow of children with neuroblastoma. They express high levels of TREM2 but display …


Harmonizing Self-Reported And Free Text Medication Data: A Reproducible Pipeline For Gerontological Research, Ramkrishna K Singh, Chen Chen, Semere Bekena, David C Brown, Kaylin Taylor, Matthew Blake, Yiqi Zhu, Kebede Beyene, David B Carr, Ganesh M Babulal Dec 2025

Harmonizing Self-Reported And Free Text Medication Data: A Reproducible Pipeline For Gerontological Research, Ramkrishna K Singh, Chen Chen, Semere Bekena, David C Brown, Kaylin Taylor, Matthew Blake, Yiqi Zhu, Kebede Beyene, David B Carr, Ganesh M Babulal

2020-Current year OA Pubs

BACKGROUND: Self-reported medication data collected as free text in gerontological and dementia research is often unstructured with inconsistent formatting. These circumstances pose a challenge for standardization and classification when preparing effective, reproducible analyses. Spelling variations, naming conventions, and reporting drug combinations can hinder mapping to standard pharmacologic vocabularies and compromise medication exposure assessments. We aimed to develop and implement a transparent, reproducible, and scalable data harmonization pipeline that ingests free-text medication records and classifies them according to American Hospital Formulary Service (AHFS) therapeutic categories. METHODS: A four-phase curation pipeline processed 30,062 Research Electronic Data Capture (REDCap) medication records collected over …


Ultrasound-Guided Diffuse Optical Tomography: An Adjunct To Ultrasound That Can Reduce Unnecessary Breast Biopsies, Quing Zhu, Debbie Bennett, Ian S Hagemann, Jaimee Mannix, Kimberly Wiele, Megan Luther, Jingqin Luo, Steven P Poplack Dec 2025

Ultrasound-Guided Diffuse Optical Tomography: An Adjunct To Ultrasound That Can Reduce Unnecessary Breast Biopsies, Quing Zhu, Debbie Bennett, Ian S Hagemann, Jaimee Mannix, Kimberly Wiele, Megan Luther, Jingqin Luo, Steven P Poplack

2020-Current year OA Pubs

BACKGROUND: Breast biopsy is recommended for any lesion in which the radiologist deems the likelihood of malignancy to be greater than 2% and more than 75% of biopsies return with benign results. This study assesses whether the total hemoglobin concentration (HbT) and blood oxygen saturation (%sO2) of malignant and benign breast lesions, obtained using Ultrasound-guided diffuse optical tomography (US-guided DOT), can help reduce benign breast biopsy rates. METHODS: 238 women consecutively recruited were examined with US-guided DOT before their US-guided biopsy. Three or four radiologists independently provided BI-RADS assessments using pre-procedure US and mammography (when available), first without and then …


An Advanced Multi-Branch Recurrent Deep Learning Model For Predicting The Antibacterial Capacity Of Nanoparticles With Shap-Based Explainability, Shaimaa M.S. Zainulabdeen, Najee B. Haifaa, Iman Ali Atiyah Dec 2025

An Advanced Multi-Branch Recurrent Deep Learning Model For Predicting The Antibacterial Capacity Of Nanoparticles With Shap-Based Explainability, Shaimaa M.S. Zainulabdeen, Najee B. Haifaa, Iman Ali Atiyah

Muthanna Medical Journal

The antibacterial properties of nanoparticles play a crucial role in industries such as textiles, water disinfection, pharmaceuticals, and food packaging. Given the rising concerns over antibiotic resistance, metal oxide nanoparticles (NPs) have emerged as a promising alternative. While machine learning techniques in nano informatics have shown encouraging results in predicting the antibacterial efficacy of nanoparticles, the application of deep learning methods in this domain remains limited. This study introduces a novel predictive model based on a multi-branch recurrent neural network, incorporating three types of recurrent cells: LSTM, BiLSTM, and GRU, to estimate the antibacterial effectiveness of nanoparticles. The proposed model …


Incidental Multiple Colonic Lipomas In A Patient With Adenocarcinoma Of The Right Colon: Case Report, Azza N. Al Jaleeli, Mohammed N. Hilmi, Mohammed Alkurtas, Shaymaa Khalid Abdulqader Dec 2025

Incidental Multiple Colonic Lipomas In A Patient With Adenocarcinoma Of The Right Colon: Case Report, Azza N. Al Jaleeli, Mohammed N. Hilmi, Mohammed Alkurtas, Shaymaa Khalid Abdulqader

Muthanna Medical Journal

Colonic lipomas are benign tumors composed of mature adipocytes. Colonic lipomas most commonly involve the right colon near the ileocecal valve and are multiple only in 10-20% of cases. To our knowledge, our case report is the first to describe numerous colonic submucosal lipomas in patients with intestinal obstruction and right-sided colonic carcinoma.