Digital Commons Network^™

Biomarker And Age At Onset Endophenotypes Offer New Insights Into The Genetic Etiology Of Alzheimer’S Disease, Joseph Bradley

Arts & Sciences Graduate Student Theses and Dissertations

Introduction: Alzheimer’s Disease (AD) remains among the top 10 causes of death in the United States and is projected to affect nearly 14 million people by 2050. To this point, studies of Alzheimer’s genetics and endophenotypes have yielded a bounty of results that culminated in the first disease-modifying drugs, lecanemab and donanemab, in 2022. Most of the genetic studies for Alzheimer’s disease to date have been focused on late-onset AD or Autosomal dominant AD, leaving a critical need for studying sporadic early-onset AD (EOAD; ~10% of cases). Furthermore, the demand for clinical portability has created a need for high-sensitivity proteomic …

Intrathoracic Manifestations Of Hematologic Malignancies: A Narrative Review, Kshama Bhyravabhotla, Gregory Gaskey, Jeremy R Walder, Diwakar D Balachandran, Sujith V Cherian, Bilal Zafar, Lara Bashoura, Ajay Sheshadri, Saadia A Faiz

Faculty, Staff and Student Publications

Background and objective: Although the global incidence of hematologic malignancies is decreasing, the risk of developing these cancers is increasing due to increased lifespan and modern treatments including targeted therapy, chemotherapy, and radiation. Intrathoracic manifestations of hematologic malignancies may be the presenting sign leading to diagnosis or result from various treatment toxicity. The most common respiratory manifestation of hematologic malignancies is infectious, but up to half of pulmonary findings are from non-infectious etiologies. We aim to summarize the current literature on non-infectious intrathoracic manifestations of hematologic malignancies and their treatment.

Methods: We performed a literature review using PubMed Central and …

The Original E-Discovery: Civil Justice Reform And A Return To The Equitable Origins Of Discovery, Patricia I. Mcmahon

Osgoode Hall Law Journal

In the autumn of 2023, the Chief Justice and Attorney General of Ontario announced a broad new effort to review the rules of civil procedure to make civil dispute resolution more efficient and less expensive to enhance access to justice in the province. However, such efforts to reform the rules of civil procedure are nothing new.

This article examines the historical and contemporary aspects of civil justice reform in Ontario, focusing on the pre-trial discovery process. Among the most expensive aspects of the civil litigation process, discovery began as an equitable tool, with roots in the English Court of Chancery. …

Poetry’S Role In Shaping Critical Thinking In Indonesian Learners Of English As A Foreign Language, Hamzah Puadi Ilyas, Nani Solihati, Istaryatiningtias Istaryatiningtias

The Qualitative Report

This research investigated the role of poetry interpretation activities in fostering the development of critical thinking abilities among Indonesian English as a foreign language (EFL) students in a higher education setting. Given the scarcity of research in this area, this study contributes to the existing body of knowledge on the subject. To this end, the research posed three research questions: (1) How does poetry influence the development of critical thinking abilities in EFL learners? (2) What types of critical thinking activities are facilitated by poetry? (3) How do students perceive the benefits of using poetry for critical thinking? A total …

Education For A Shared Society In Wartime: A Faculty Of Education Dean’S Autoethnography, Ilana Paul-Binyamin

The Qualitative Report

My autoethnographic study emerged in the wake of the Hamas–Israel war that began on October 7, 2023, placing me in a dual position as both an academic leader and a member of a society in crisis. As Dean of a multicultural Faculty of Education, I reflect on how the war disrupted longstanding efforts to promote shared society education between Jews and Arabs. Drawing on personal narratives, reflective fieldnotes, and case studies from campus life, I explore how trauma, fear, and political polarization undermined the multicultural frameworks I had developed over years of practice. I document moments of rupture—between students, faculty, …

Ethnic Diversity In Uk Bioscience: Structural Biases And Recommendations For Action, Yusra Siddiqui, Prachi Stafford, Emmanuel Adukwu, Nicholas Freestone, Tina Lovleen Joshi, Emma Yhnell, Katharine Hubbard

Peninsula Dental School

Scientific research is more innovative and impactful when scientists are drawn from diverse backgrounds. However, the scientific community does not reflect the demographics of wider society. Global Majority communities remain underrepresented within science, particularly within senior leadership roles. Here we explore ethnic diversity within UK academic biosciences, using publicly available staff and student demographic data from the UK Higher Education Statistics Authority. We use the Simpson index as a quantitative measure of diversity within the biosciences and construct linear mixed effect models to identify significant predictors of both student and staff ethnic diversity. For staff, there were significant negative effects …

The Non-Reciprocity Of Cultural-Ecological Resilience In Eastern Sumba, B. Retang Wohangara

Paradigma: Jurnal Kajian Budaya

Resilience is one key concept of culture and ecology. It highlights a particular system's adaptive and thriving capacities in facing various challenges. This research-based article investigates the reciprocity of cultural-ecological resilience in three traditional communities in Eastern Sumba. It starts with the examination of cultural resilience and ecological resilience using five and seven qualitative indicators, respectively. The last part of the discussion analyzes how culture and ecology reciprocate in the given communities. The research employs a descriptive qualitative method. Data are collected by conducting mini-ethnographic field research for interviews, documentation, and focus group discussions. Using the five and seven indicators …

From Chinese Folk Religion To Tridharma: The Trajectory Of Chinese Religion In Indonesia, Refan Aditya

Paradigma: Jurnal Kajian Budaya

This article explores the trajectory of Chinese folk religion and the institution of klenteng (Chinese temple) within the broader discourse of Chinese religion in Indonesia, spanning from the colonial period to the post-reform era. Employing a historical and anthropological approach, this study examines Chinese religious discourse through Chinese-peranakan publications from the colonial era. It presents contemporary practices of Chinese folk religion and temple life as part of that evolving discourse. Historically and anthropologically, Chinese folk religion has been deeply embedded in the religious life of Chinese communities. However, its resonance has gradually degraded under the dominating religious narratives, particularly due …

Untouchable Beauty Of Everyday Aesthetics In Wim Wenders’ Perfect Days, Nindya Galuh Fatmawati, Agni Saraswati

Paradigma: Jurnal Kajian Budaya

Wim Wenders, in his latest film Perfect Days (2023), presents an everyday aesthetic experience conveyed through a visually striking aesthetic characterized by a "peaceful" gaze. This study aims to explore the everyday aesthetics depicted in Perfect Days, which align with traditional Japanese aesthetics, specifically wabi-sabi. The analysis is framed using Todd McGowan's Cinema of Desire theory. The research employs a qualitative descriptive method to examine the subject and utilizes a Psychoanalytic approach for analysis. The findings reveal that object ‘a’ in Perfect Days is highlighted through mise-en-scène and music, as these two cinematic elements facilitate a moment of …

Gender Differences In Japanese Elderly Learning Motivation, Yesy Tri Cahyani, Kurniawaty Iskandar, I Ketut Surajaya, Kosuke Mizuno, Jumanto Jumanto, Emila Ligia

Paradigma: Jurnal Kajian Budaya

Ageing is likely to become a 'gender issue' with a big number of women surviving into very old age in almost all the countries of the world. Japanese women have longer longevity than Japanese men. What is the secret behind the higher lifespan of Japanese women compared to Japanese men? Is it related to their ikigai? In this qualitative approach research, we chose the subjects as elderly men and women who participated in Easy English Conversation Courses in Kitakyushu Nenchousha Daigakkou (Kitakyushu Elder University). We assumed that to participate in Easy English Conversation Courses may change their life and …

Roblox As Open Text: Identity, Meaning, And Ideology Through Eco’S Semiotics, Yuyus Rustandi, Nanang Sutisna

Paradigma: Jurnal Kajian Budaya

This study examines Roblox as a digital cultural space that constructs and represents adolescent identity through Umberto Eco's semiotic approach. Roblox functions not only as a game platform but also as an open text comprising visual signs, social symbols, and complex narratives. This studi is based on a literature review from nine prior empirical studies, this research analyzes how avatars, virtual environments, Robux economy, and user communities shape diverse systems of meaning. Findings show that Roblox serves as a site for identity construction, simulation of social values, and reproduction of dominant discourses such as capitalism and gender performance. The study …

Translating The “Preposition + Which” Construction In English Legal Texts Into Indonesian, Doni Jaya

Paradigma: Jurnal Kajian Budaya

Legal text translation is challenging because of its emphasis on semantic and syntactic faithfulness, while ST structures do not always have correspondent TL equivalents. One of such structures is the English “preposition + which” (PW) construction. This construction can be difficult to translate into Indonesian because the language does not always have ready-to-use connectors to produce a structurally faithful translation, often forcing translators to take the easy way of using ungrammatical and unnatural connectors which becomes the hallmark of the Indonesian legalese style. This research seeks to examine various ways to translate PW constructions in a more grammatical and …

Exploring Hrm Practices In Academia: Comparative Insights From The Employees Of Polish, Maltese, And Finnish Universities, Sylwia Przytuła, Łukasz Sułkowski, Colin Borg

European Management Studies

Purpose: The aim of this article is threefold: to gain detailed insights into academic employees’ experiences and perceptions of human resource (HR) practices; to identify the challenges and opportunities perceived by academic actors in these practices; and to provide recommendations for further research.

Design/methodology/approach: The study involved 17 key informants from Polish (8), Maltese (5), and Finnish (4) universities. Data were analysed using semantic thematic analysis, resulting in a rich and nuanced understanding of the experiences shared by participants.

Findings: Findings reveal that respondents are primarily motivated to pursue academic careers due to institutional reputation, professional development …

European Management Studies 2025, Vol. 23, No. 4

European Management Studies

European Management Studies 2025, vol. 23, no. 4

Modular Construction And The Building Blocks Of Litigation: Navigating The Legal Framework Between The Ucc And Common Law, Rilee White

Georgia Law Review

The development of modular construction has re-raised a question central to construction litigation: whether contracts are governed by Article 2 of the UCC, which controls transactions in goods, or the common law, which controls other transactions, including those for services. Because the modular construction process involves fabrication of units off-site, it complicates the distinction between goods and services—while the final product is the service of constructing a building, the individual modules could arguably be classified as goods.

Although courts have historically treated processes involving prefabrication as the sale of goods, modern modular projects are increasingly becoming more customizable and service-driven. …

The Future Of The Furman Challenge To The Death Penalty, Scott W. Howe

Georgia Law Review

This article revisits the core argument against the death penalty that Professor Anthony Amsterdam offered in Furman v. Georgia. The article situates itself, however, in a modern, forward-facing context by accounting for post-Furman death penalty developments. These include the thirteen federal executions during the last six months of President Trump’s first term, the thirty-seven commutations of federal death sentences by President Biden, and the executive order by President Trump, issued on the first day of his second term, directing vigorous use of the federal death penalty and aid and encouragement in the use of capital punishment by the …

Gravitational Property Theory, Monika U. Ehrman

Georgia Law Review

Isaac Newton and Albert Einstein defined and redefined the field of physics. Their theoretical work on gravity is still considered a monumental discovery of their respective times. Although born centuries apart, the theory of gravity each advanced is still essential. Newton’s theory is applied on Earth and throughout much of the solar system, while Einstein’s theory is used in special environments, such as near black holes. Neither theory is discarded, but instead used where appropriate. Likewise, gravitational property theory proposes that simple property theory—the ad coelum doctrine—is still appropriate for simple property, like stationary or vertical objects. And complex property …

Intercontinental Variation In Population Genetics And Life-History Traits In Native And Invasive Populations Of The Aquatic Plants Myriophyllum Spicatum And Myriophyllum Sibiricum, Anastasia V. Mozharova

Graduate Doctoral Dissertations

Biological invasions pose significant threats to freshwater ecosystems worldwide, and understanding their evolutionary, genetic, and biogeographic drivers is essential for effective management. My dissertation integrates microsatellite and ITS rDNA data to examine the dynamics of both invasive and native populations of two closely related aquatic plant species, Myriophyllum spicatum (Eurasian watermilfoil) and M. sibiricum (Northern watermilfoil).

Myriophyllum spicatum is native to Eurasia, where it inhabits a variety of freshwater aquatic habitats. Since its introduction to North America in the mid-20th century, it has become highly invasive, forming dense underwater mats that outcompete native vegetation, reduce biodiversity, and degrade water quality. …

Correlation Of F2-Isoprostane With Interleukin-6 And Interleukin-10 In Transfusion-Dependent Thalassemia Patients : A Cross-Sectional Study, Nurul Muhlisa, Yetti Hernaningsih, Puspa Wardhani, Mia Ratwita Andarsini, Zulfikar Ali Hasan

Folia Medica Indonesiana

Transfusion-dependent thalassemia (TDT)[-7pc]AU: Please Provide authors affiliations. is a condition in which patients require lifelong regular blood transfusions. However, regular blood transfusions carry a major risk of iron overload, which accumulates in the body and can trigger oxidative stress and chronic inflammation. Oxidative stress is characterized by an increase in reactive oxygen species (ROS), which can be assessed through the measurement of F2-Isoprostanes (8-iso-PGF2α). Excessive ROS affects cytokine production by inducing an inflammatory response, such as IL-6 and IL-10. This study aims to analyze the correlation between F2-isoprostane with Interleukin-6 and Interleukin-10 levels in TDT patients. This research …

Transforming Vision: Long Term Follow-Up Of Rigid Gas Permeable Contact Lens Therapy In Anisometropic Amblyopia, Christina Aritonang, Sarah Fauzia, Zafirah Mutiani, Hafiza Izyani Yaacob, Muhammad Irfan Kamaruddin

Folia Medica Indonesiana

Amblyopia is defined as a unilateral or bilateral reduction in visual acuity resulting from abnormal binocular interaction during the critical period of visual development. Amblyopia is classified into three etiologies: strabismus, refractive amblyopia, and other vision obstructions. Amblyopia refractive is the most common form resulting from the integration of the retina. Amblyopia is most prevalent in childhood, with a global prevalence of 1.44% mainly in Asia, the United States, and Europe. Early detection and treatment are crucial to ensure proper visual development and prevent long-term vision problems. RGP contact lenses are an alternative treatment method that creates a more effective …

Preliminary Laboratory Evaluation Of Rapid Diagnostic Test Prototype To Detect Hbsag In Whole Blood And Serum, Ema Qurnianingsih, Citrawati Dyah Kencono Wungu, Mochammad Amin, Dewi Setyawati, Yanna Debby Restifanny Yasan, Lina Lukitasari, Maria Inge Lusida, Soetjipto Soetjipto

Folia Medica Indonesiana

Chronic hepatitis B virus (HBV) remains a major global health issue,[-10pc]AU: Please provide ORCID ID for all authors.[-7pc]AU: Please provide affiliation’s for all authors. with over 250 million people affected worldwide. In Indonesia, HBV prevalence has declined from high to moderate endemicity, but challenges persist due to regional disparities, risk of mother-to-child transmission, and the predominance of B3 and C1 sub-genotype. Despite available preventive measures and diagnostic tools, approximately 90% of cases remain undiagnosed, particularly in low-resource settings, indicating the need for improved screening and control strategies. Therefore, this study aims to conduct preliminary performance tests of KODC hepatitis B …

Comparison Of Intraperitoneal And Intraductal Routes In The Growth Of N-Methyl-N-Nitrosourea-Induced Breast Cancer In Sprague Dawley Rats: A Systematic Review 2014–2024, Adilla Soraya Prameswari, Ruendhita Azzahra Sari Sompokan, Annisa Annisa, Rachma Greta Perdana Putri, Dewi Yuniasih, Muhamad Danian, Muhammad Tri Yoga Tianotak

Folia Medica Indonesiana

Breast cancer is one of the[-6pc]AU: Please provide affiliations for your paper. leading causes of death for women worldwide, characterized by malignant tumors in the mammary epithelium. Breast cancer modelling using Sprague Dawley animals induced by N-Methyl-N-Nitrosourea (MNU) compounds is commonly used through various administration routes. The intraperitoneal route is the conventional route and the intraductal route is a new route capable of directly targeting the mammary ducts. Both routes affect the speed and characteristics of breast cancer cells in experimental animals. This systematic review using PubMed and Scopus databases from 2014-2024 aims to compare the effects of intraperitoneal and …

Global Analysis Of Pyroptosis On Autoimmune Diseases: Bibliometric Study, Astri Dewayani, Kartika Afrida Fauzia

Folia Medica Indonesiana

Pyroptosis has gained increasing attention due to its role in immune responses and its implication in the pathogenesis of autoimmune diseases. Unlike apoptosis, pyroptosis is characterized by gasdermin D-mediated membrane pore formation and the release of pro-inflammatory cytokines. This bibliometric analysis aims to systematically explore trends, influential contributions, and emerging themes in the study of pyroptosis within the context of autoimmune diseases. Literature was retrieved from the Web of Science Core Collection covering publications from 2015–2024. A total of 1,271 English-language articles and reviews were analyzed using Biblioshiny and VOSviewer for performance metrics and network visualizations. Hotpots trend identification is …

The Role Of Linear Programming And Sensitivity Analysis In Improving The Transportation And Distribution Of Vegetable Oils: A Case Study Of The State Company For Vegetable Oils In Iraq, Zainab Alaa Hameed

Muthanna Journal of Administrative and Economics Sciences

The State Company for Vegetable Oils in Iraq faces a fundamental challenge of high transportation costs and inefficiency in distributing products across factories and warehouses to meet growing demand. Accordingly, this study aims to employ operations research methods-specifically linear programming and sensitivity analysis---to design a distribution plan that enhances efficiency and minimizes costs. The methodology involved developing a mathematical model of the transportation problem based on actual data related to supply quantities, demand requirements, and transportation costs between production sources and distribution outlets. The model was solved using WinQSB software to determine the optimal solution. Sensitivity analysis was then conducted …

The Impact Of Organizational Sustainability On Improving Companies’ Financial Performance (Applied To The Southern Refineries Company.), Thaer Khalaf Khashan

Muthanna Journal of Administrative and Economics Sciences

The impact of organizational sustainability on improving companies' financial performance, applied to the Southern Refineries Company. The research aims to explore the impact oforganizational companies' financial performance. The research variables were organizational sustainability as an independent variable with its three dimensions (economic sustainability, social sustainability, and environmental sustainability), and improving financial performance as a dependent variable. To achieve the research objectives, the descriptive analytical approach was adopted. A questionnaire was used as a tool for data collection. The questionnaire was distributed to a random sample of (400) individuals from the employees of the Southern Refineries Company, (388) questionnaires were retrieved, …

The Impact Of Implementing Good Governance Principles On The Quality Of University Education: An Analytical Study Of The Opinions Of A Sample Of Employees At Sawa Private University, Thanaa Hussein Jalil Al-Khuzaie

Muthanna Journal of Administrative and Economics Sciences

This study aims to analyze the impact of applying good governance principles—such as transparency, accountability, participation, and the rule of law—within higher education institutions on the quality of university education, by examining the relationship between these principles and academic and administrative quality indicators. The study population comprised academic and administrative staff at Al-Sahel Private University. A stratified random sample of 75 participants was selected from the university. Data were analyzed using descriptive statistics (mean, standard deviation), Pearson correlation coefficient, and coefficient of variation. The instrument’s reliability was assessed using Cronbach’s alpha, and factor analysis was conducted. Hypotheses were tested using …

The Impact Of Using Management Information System On Enhancing Intelligent Organizations: An Exploratory Study Of The Opinions Of A Sample Of Faculty Members At The College Of Administration And Economics – University Of Mosul, Ali Jasim Shalash

Muthanna Journal of Administrative and Economics Sciences

The present study seeks to investigate the effect of the dimensions of the Management Information System (MIS) on fostering intelligent organizations, through analyzing the relationship between the system’s components (organization, human resources, information technology, and data/information) and the level of organizational intelligence. The research employed a descriptive–analytical methodology, with data collected from a sample of 88 faculty members at the College of Administration and Economics, utilizing a scientifically designed questionnaire. The results indicated a strong and statistically significant correlation between all MIS dimensions and the development of intelligent organizations, with the system accounting for 43.3% of the variance in organizational …

The Role Of Transformational Leadership In Achieving Strategic Recovery: A Survey Study Of The Opinions Of A Sample Of Directors In The General Directorate Of Education In Nineveh Governorate, Mariam Moneim Malallah Al-Halawajy

Muthanna Journal of Administrative and Economics Sciences

The current study aims to shed light on the role of transformational leadership as an independent variable, embodied in four dimensions (idealized influence, inspirational motivation, intellectual stimulation, and individualized consideration), in achieving strategic recovery as a dependent variable, represented by three dimensions (apology, compensation, and rapid response) at the General Directorate of Education in Nineveh Governorate. To achieve the objectives of the study, the descriptive–analytical approach was adopted as a methodological framework to accurately observe and analyze relationships. A validated questionnaire was designed for data collection and distributed to a sample of managers working in the Directorate, numbering (98). The …

Assessment Perception: Delivery Matters, Nicole Marie Arcuri-Sanders, Chelsey Simmons

Educational Sciences and Organizations

Perception shapes how individuals experience the world and guides their actions toward personal goals. In counseling, clients’ accurate understanding of assessment results is essential for informed decision-making and effective treatment engagement. Mental health clinicians have an ethical responsibility to communicate findings in ways that safeguard client welfare and empower both clients and stakeholders to collaborate in care. This conceptual manuscript introduces the BRIEF (Brief, Relevant, Interpretive, Empathetic, and Factual) Feedback Integration Framework, a structured model for delivering assessment feedback ethically and accessibly. Integrating cognitive, developmental, and cultural considerations. BRIEF provides counselors, supervisors, and educators with a practical strategy for improving …

Optimal Sizing Of Pv Water Pumping System For Off-Grid Rural Communities, Basma Abulkheir, Eid Gouda, A. A. Hegazi, Amir Abdel Menaem

Mansoura Engineering Journal

A large population worldwide lives in remote rural communities without access to electricity due to the limited reach of national transmission networks. This creates significant challenges in accessing water, hindering improvements in living conditions for off-grid communities. Photovoltaic water pumping systems (PVWPSs) offer a viable solution to this issue, but their sustainability must be examined due to the unpredictable nature of solar radiation. This paper presents a practical techno-economic approach to optimally size a PVWPS. A Particle Swarm Optimization (PSO) algorithm is employed, considering technical and economic indicators like life cycle cost, loss of load probability and PV curtailment rate. …