Digital Commons Network^™

Antipsychotic Misuse: A Silent But Growing Public Health Hazard, Sumeet Bhardwaj, Karisma Pathak, Myra Mclenon, Steven Spector, Kevin Tu

Student Publications

Antipsychotic drugs are essential in the management of schizophrenia, bipolar disorder, and other psychiatric illnesses, but their use is closely linked to cardiometabolic side effects. Cardiometabolic side effects include weight gain, dyslipidemia, glucose intolerance, and increased cardiovascular morbidity and mortality. Mechanisms of cardiometabolic side effects involve disruption of the central nervous system’s ability to regulate appetite, peripheral metabolic effects, which are changes in metabolism outside the CNS, and receptor-level interactions, with second-generation antipsychotics generally posing a greater risk than first-generation agents. This review addresses current evidence on the cardiometabolic consequences of antipsychotic therapy, increasing inappropriate off-label use of antipsychotic drugs, …

Virtual Reality Protocol Development For Bone Marrow Aspiration And Biopsy In Adults With Blood Cancers, Maria Motta

Doctoral Scholarly Projects & Capstones

Patients with hematologic malignancies such as leukemia, multiple myeloma, and lymphoma frequently undergo bone marrow aspiration and biopsy (BMAB) procedures throughout their treatment trajectory. At a comprehensive cancer research hospital in southern California, these procedures were commonly performed on an outpatient basis by nurse practitioners and physician assistants while patients remained awake under topical anesthesia. Despite these measures, patients consistently reported significant pain and anxiety during BMAB procedures (Glennon et al., 2018). Current literature supported the use of virtual reality (VR) as an effective non-pharmacologic intervention to reduce pain and anxiety in cancer populations (Ahmad et al., 2020). However, the …

Ethnomusicologically Augmented French Diction Course, Jake Larcqua

Doctoral Scholarly Projects & Capstones

Modern diction pedagogy in university vocal performance education largely depends on a combination of International Phonetic Alphabet transcription study and the application of those systems to Western-Classical vocal repertoire. However, recent research in related fields suggests we may be able to expand our diction teaching methods to better meet the needs of our students. Using a combination of second-language pedagogic principles, folksong structure, self-efficacy concepts, modeling structures, and ethnomusicological perspectives on classroom culture, I have drafted a French diction course that should improve not only students’ performance within university vocal music education, but also students’ confidence in their ability to …

Evaluating The Housing Disparities Surrounding 1890 Land-Grant Universities And 1862 Land-Grant Universities In The South, Jimmy Henry

All Dissertations

This dissertation investigated the disparities in housing and economic development surrounding 1890 and 1862 land-grant universities in the southern United States, highlighting the differences between Historically Black Colleges and Universities (HBCUs) established by the 1890 Morrill Act, and Predominantly White Institutions (PWIs) established under the 1862 Morrill Act. These Morrill Acts established the first federal support for higher education in agriculture and mechanical arts, granting land and, in the case of 1862 institutions, financial resources:

This dissertation was guided by six research questions, applied by both the Hedonic Price Model and comparative analysis: (1) How do housing structure types differ …

Evaluation And Identification Of Risk Factors For Stress Among Maquiladora Workers Based On The Mexican Official Standard 035 Survey Tool, Andrea Baca Melendez

Open Access Theses & Dissertations

Background and significance: Occupational psychosocial risk factors are workplace conditions that can trigger physiological, emotional, cognitive, and behavioral changes. They are strongly associated with mental health issues such as anxiety and depression, as well as non-mental health conditions like myocardial infarction, stroke, and occupational injuries. Analyzing these risks from a sociodemographic perspective provides valuable insights for improving work environments and workers’ well-being. Purpose: This study aimed to identify and determine the levels of occupational psychosocial risk factors among workers in a manufacturing company in Cd. Juárez, Chihuahua, and to examine their relationship with sociodemographic variables to inform future interventions in …

Enduring Efffects Of Juvenile Fluoxetine Exposure On Serotonin Transporter Expression Within The Hippocampus And Prefrontal Cortex Of Male C57bl/6 Mice, Daniel Eduardo Calvo

Open Access Theses & Dissertations

Prescription rates of fluoxetine, the most dispensed selective serotonin reuptake inhibitor, have been rising among the juvenile population. Since adolescence is a critical developmental period in which the brain undergoes pruning, chronic increases in serotonin levels may lead to long-term neurobiological changes in brain regions responsible for emotional regulation. Thus, using mice as a model system, this thesis evaluated how adolescent fluoxetine exposure (AFE) influences the expression of serotonin transporters (SERT) in the adult hippocampus and prefrontal cortex. To do this, postnatal day (PD)-35 male C57BL/6 mice were administered with fluoxetine (250 mg/l in their drinking water) for 15 consecutive …

Ai-Facilitated Abuse & Misogyny: A Feminist Response To Non-Consensual Intimate Image Deepfakes, Lizbeth Carmona

Open Access Theses & Dissertations

The creation of non-consensual intimate images utilizing AI deepfake technology has been demonstrated to overwhelmingly target women. The harms of non-consensual intimate image deepfakes are similar to other forms of misogynistic abuse, including intimate image abuse and online objectification. This project seeks to contextualize this phenomenon within feminist accounts of misogyny and its role in regulating women's behavior. In particular, this project highlights that the accessibility of this technology has lowered the threshold of abuse, despite the individual woman's preventive measures. Furthermore, this project argues that the dissemination of non-consensual intimate image deepfakes is a morally problematic situation because it …

Borderlines Of Becoming: Transfronterizx College Students Navigating Surveillance, Hybridity And Belonging Along The Us-México Border, Aylin Garcia

Open Access Theses & Dissertations

This narrative literature review examines the educational experiences of transfronterizx college students along the U.S.– México border, a population largely absent from higher education scholarship. Drawing on Borderlands Theory, Anzaldúa’s frameworks, and critical perspectives on neoliberalism and militarization, this thesis highlights the border as a site of both constraint and possibility. Structural violence, surveillance, and militarization intersect with linguistic, racial, and class hierarchies to shape students’ mobility, identities, and sense of belonging. At the same time, students mobilize hybrid identities, cultural wealth, and transborder networks to assert agency, cultivate belonging, and resist deficit narratives. It also identifies persistent gaps, particularly …

Our Trajectories As We Leave The Teaching Profession: Pláticas With Former Bilingual Teachers On The U.S.-Mexico Border In Texas- An Explanatory Sequential Mixed-Methods Study, Carla Medina Jaquez

Open Access Theses & Dissertations

Teacher attrition has had a negative impact on the educational system for many years. New and experienced teachers have been leaving the classroom. Although the reasons appear repetitive, we know relatively little about what teachers must go through when deciding to leave the profession and what happens to them afterward. A teacher shortage is occurring along the U.S.-Mexico border, as in many other cities across the United States. Despite undergoing a lengthy certification process, teachers continue to leave the classroom. This research employed an explanatory sequential mixed-methods design to explore how new and experienced teachers navigate their transition out of …

Exploring Intersectional Risks Of Substance Use Disorder, Mental Health, Hiv/Aids, And Hepatitis C Among Hispanic Adults On The Tx-Mx Border: A Mixed-Methods Study, Md Mohsin

Open Access Theses & Dissertations

Purpose: The purpose of this study was to explore intersectional risks of substance use disorders, mental health, HIV/AIDS, and HCV among Mexican-origin Hispanic adults on the Texas-Mexico border. Methods: The study employed an exploratory sequential mixed-methods approach, which involved collecting and analyzing qualitative data first, followed by quantitative data collection. Selected purposively, 15 in-depth interviews were conducted among the target population. Using convenient sampling, 106 cross-sectional surveys were conducted. Qualitative interview data were analyzed manually using thematic analysis. Quantitative data analyses included univariate descriptive analysis, bivariate, and multivariable penalized logistic regression, negative binomial, and zero-inflated negative binomial regression. Results: The …

Voices At The Intersection: A Listening Guide Analysis Of Campus-Based Advocates Navigating Institutional Policies On Sexual Violence, Arely Zaragoza-Hernandez

Open Access Theses & Dissertations

Campus-based advocates occupy a critical yet complex position within higher education institutions (Nightingale, 2023; Wood et al., 2021), serving as frontline support for students while simultaneously navigating the mandates, policies, and bureaucratic structures that define their roles. This research study explores the lived experiences of advocates working in university settings, focusing on how institutional mandates from compliance requirements to administrative expectations shape, constrain, and sometimes empower their daily practices. Using a qualitative, phenomenological approach, the study centers the voices of campus-based advocates in Texas to illuminate the tensions between their professional commitments to student-centered care and the institutional imperatives of …

Branding The Divide: Political Ideology And The Strategic Challenges Of Higher Education Marketing, Oscar J. Early Mr

Electronic Theses and Dissertations

The purpose of this qualitative study was to explore how first-year students experience and interpret institutional branding within the context of their personal and social identities, with particular attention to the role of political ideology. While previous research had examined general branding strategies and declining public trust in higher education, scholars have given little attention to the ways in which prospective students make meaning from institutional messaging during one of the most significant transitions of their lives.

I conducted interviews with 12 first-year students from four-year colleges and universities across South-Central Appalachia. The phenomenological analysis revealed that students’ interpretation of …

Undergraduate Students' Perceptions Of Sense Of Belonging And Engagement Opportunities In The Campus Community, Shelby Jo Akers

Electronic Theses and Dissertations

This non-experimental, correlational, quantitative study examined the relationship between undergraduate students’ perceptions of sense of belonging and their participation in university programming and engagement opportunities at a medium-sized public institution in the Southeastern United States. Guided by the Integrative Framework for Belonging (Allen et al., 2021), the study explored how specific student factors including academic major, campus residency status, class standing, primary mode of instruction, and employment status intersect with engagement to shape students’ sense of belonging. Engagement opportunities that were measured included dimensions of campus facility use and participation in clubs and organizations. Questions related to perceptions of the …

Collective Action Under Repressive Conditions: Integration Of Individual, Group, And Structural Level Research, Recommendations, And Reflections, Arin H. Ayanian, Aya Adra, Fouad Bou Zeineddine, Rim Saab, Johanna Vollhardt, Nicole Tausch

Psychology

Social scientific research from different traditions on collective action under repressive conditions is fragmented across different levels of analysis. The current paper takes a first step toward remedying this fragmentation by reviewing research findings on repression and collective action and organizing them into a multilevel framework. We describe the impact of repression on antecedents of collective action at the (a) individual level (including grievances, emotions, efficacy beliefs, politicized identity, and individual differences), (b) group level (including community cohesion and norms), and (c) structural level (including political opportunities and socioecological conditions). We then present an integrative summary reflecting on the broad …

Study Protocol For The Rainbow Austrian Longitudinal Family (Ralf) Study: A Longitudinal, Multi-Method, Multi-Rater Investigation Of Risk And Resilience Factors In Austrian Lgbtq+ Parent Families, Betty Geidel, Magdalena Siegel, David Steryl, Abbie E. Goldberg, Guy Bodenmann, Martina Zemp

Psychology

Background: Research on LGBTQ+ parent families is evolving to include a growing range of family systems, identities, methodologies, and topics. However, studies that examine minority-specific risk and resilience factors and their associations with within-family processes remain scarce, particularly outside a US-American context. Addressing these research gaps quantitatively poses challenges for researchers, because traditional modelling techniques based on (generalized) linear models are not ideally suited to capture the complexity and intersectionality of family experiences. Within this study protocol, we introduce the Rainbow Austrian Longitudinal Family (RALF) study. Its main goal is to comprehensively investigate general and minority-specific factors that affect the …

Conflict Management: Values-Based Training Effects On Shifts In Strategy Preference Among Formerly Incarcerated Individuals, Candace Renae Fay

Theses and Dissertations

Problem-solving refers to a behavior evoked by a problem in which the behaver manipulates, supplements, and consequently, generates discriminative stimuli (SD) that they subsequently respond to (Donahoe & Palmer, 2004; Skinner, 1957, 1968). The use of problem-solving when faced with interpersonal conflict reflects pro-social behavior patterns, while providing a learning opportunity for identifying relevant variables and contingencies, and possible reductions of extended conflict or escalation in anti-social behavior patterns. Patterns of preference can be identified following multiple opportunities, given an array of options, resulting in consistency of choice responses (Martin, 2006). When less prosocial (avoiding, yielding), or antisocial (forcing) conflict …

Culture-Dependent Characterization Of Microbial Succession And Persistence In The Integrated Lunar/Martian Analog Habitat (Ilmah), Haley Olivia Boles

Theses and Dissertations

This study examines culture-dependent microbial monitoring in a closed lunar/Martian analog habitat, focusing on viable community dynamics relevant to long-duration missions. A standardized sampling and cultivation pipeline was implemented in ILMAH to track microbial succession and persistence under realistic operational conditions. Surface samples were collected across eight habitat zones at five mission timepoints (Days 0, 5, 10, 15, 20) during a 21-day crewed mission. Samples were concentrated post-collection and plated on chromogenic film media to quantify total aerobic bacteria (AC-R), fungi (YM-R), E. coli (EC), and S. aureus (SA). Plates were imaged and enumerated digitally; representative colonies were isolated and …

Resistance Through Policy: Documenting Lgbtq+ Advocacy In Public Education, Rhys Mitchell Fryar

Theses and Dissertations

This research examines how educational policies related to LGBTQ+ students are constructed, interpreted, and implemented across federal, state, and district-levels. It asks whether institutional intent reflects authentic commitment to equity or functions as symbolic compliance in politically contested environments. Using Portland Public Schools (PPS) as a case study, the analysis situates the district within Oregon’s affirming policy landscape and the Trump administration’s restrictive federal mandates. PPS has adopted policies, such as Administrative Directive 4.30.061 AD (2023b) and the Gender Identity Support Guide (2023a), to support queer and gender-expansive students; however, it faces a federal investigation (U.S. Department of Education, 2025b, …

Integrating Cognitive And Visual Scanning Strategies In Flight Instruction: Effects On Student Pilots’ Learning During Approach And Landing, Hyungwoo Jo

Theses and Dissertations

This interdisciplinary study employed a convergent parallel mixed-methods design to advance innovation in aviation education by incorporating eye tracking technology with enhanced performance traceability through visual modeling and comparative feedback. Specifically, the study investigated student pilots’ scanning behavior, cognitive strategies, and proficiency development on a normal approach and landing task by modeling flight instructors’ cognitive behavior. The first research phase revealed statistically significant differences in scanning ratios between 10 flight instructors and 10 student pilots along with substantial performance variation. The result showed that student pilots exhibited excessive outside fixation, often failing to monitor or respond to energy management in …

False Memory Susceptibility In Association With Attachment Theory: Effects On Memory Conformity, Rachel Catherine Miller

Theses and Dissertations

False memory research has been an evident topic in various fields of psychological study. Research in this area has important implications in forensic contexts and clinical settings as false memories can result in an array of harmful consequences. To explain individual differences in susceptibility to endorsing false memories of the rare medical procedure known as the voiding cystourethrogram (VCUG), the current study extended the findings of Herndon and colleagues (2014). It also examined predictor variables from attachment theory (such as attachment anxiety and avoidance), depressive symptomatology, compliance levels (e.g., use of confederates), and the impact of guided imagery (i.e., a …

Examining The Utility Of Haptic Feedback To Improve Pilot Situational Awareness & Performance: A Psychophysiological Approach, Jessica Van Bree

Theses and Dissertations

Pilot situational awareness (SA) has been deemed to be a critical component of flight efficacy, efficiency, and overall mission success. Studies have shown that several incidents and accidents have been the result of level-one SA errors, meaning that members of the flight crew have failed to accurately perceive the elements in their environments. As such, several strategies have been investigated to improve pilot SA. One potential avenue of research is the addition of haptics in to the flight deck. In some studies, the implementation of haptics have shown to improve piloting tasks, pilot safety, and aircraft control. The current study …

Standardized Research Electronic Cigarette Acceptability Among Adult Men And Women Who Smoke Combustible Cigarettes, Jason D Robinson, Yong Cui, Maher Karam-Hage, Janice A Blalock, Sanjay Shete, Peiying Yang

Faculty, Staff and Student Publications

Objective: The U.S. electronic cigarette marketplace is diverse and has evolved rapidly. To provide a standardized research model, the U.S. National Institute on Drug Abuse developed the Standard Research E-Cigarette (SREC). This study characterized potential gender differences in product use, acceptability, reinforcement, and nicotine dependence symptoms when switching from combustible cigarettes (CCs) to nicotine and placebo SRECs.

Method: In total, 169 adults (82 women) who smoke were enrolled in this all-remote randomized double-blind crossover trial. During Weeks 1-2, participants used their usual brand cigarettes (UBCs). During Weeks 3-4 and 5-6, they were instructed to use the tobacco-flavored SREC (either nicotine …

Smags-Lasso: A Novel Feature Selection Method For Sensitivity Maximization In Early Cancer Detection, Hamid Khoshfekr Rudsari, Sara Khorami-Sarvestani, Johannes F Fahrmann, James P Long, Samir Hanash, Ehsan Irajizad

Faculty, Staff and Student Publications

Background: Sensitivity and specificity are foundational metrics for cancer detection tools. However, most machine learning algorithms prioritize overall accuracy during optimization, which fails to align with clinical priorities of early detection. We aim to develop a feature selection machine learning algorithm while maximizing sensitivity at a given specificity.

Methods: We developed SMAGS-LASSO, a machine learning algorithm that combines our developed Sensitivity Maximization at a Given Specificity (SMAGS) framework with L1 regularization for feature selection. This approach simultaneously optimizes sensitivity at user-defined specificity thresholds while performing feature selection. SMAGS-LASSO utilizes a custom loss function with L1 regularization and multiple parallel optimization …

Symptom Burden, Healthcare Utilization, And Risky Behaviors In Survivors Of The Childhood Cancer Survivor Study (Ccss): An Observation Cohort Study, Rachel Webster, Deo Kumar Srivastava, Lu Xie, Himani Darji, Wei Liu, Tara M Brinkman, Kirsten K Ness, Bernard Fuemmeler, Alicia S Kunin-Batson, I-Chan Huang, Gregory T Armstrong, Rebecca M Howell, Daniel M Green, Yutaka Yasui, Kevin R Krull

Faculty, Staff and Student Publications

Background: Childhood cancer survivors face physical, psychological, and neurological symptoms that contribute to risky health behaviors and increased healthcare utilization. Traditional survivorship care models overlook risk associated with this symptom burden. The current study examined symptoms phenotypes to identify high-risk groups.

Methods: Five-year survivors (N = 17,231; Mean [standard deviation] age = 27.4 [5.98]; 80% non-Hispanic White; 48% female) from the Childhood Cancer Survivor Study (NCT01120353) self-reported symptoms and risky behavior at baseline and first follow-up (original cohort data collection: baseline 1994-1998 and follow-up 2002-2004; expansion cohort: baseline 2008-2010 and follow-up 2014-2016). Medical records were extracted through chart …

Adherence To Breast Cancer Screening Guidelines Among Age-Eligible Us Women: Findings From Nhis 2021, Monalisa Chandra, Joël Fokom Domgue, Robert Yu, Sanjay Shete

Faculty, Staff and Student Publications

Background: Despite the proven benefits of early breast cancer detection in reducing mortality, adherence to breast cancer screening guidelines in the United States is suboptimal. In this study, we assessed the prevalence and factors associated with adherence to breast cancer screening guidelines.

Methods: Using nationally representative data from the National Health Interview Survey 2021, we included breast cancer screening-eligible women (aged 50-74). Descriptive statistics and population-weighted multivariable logistic regression were employed to examine breast cancer screening adherence per the United States Preventive Services Task Force guidelines, and its determinants in this population.

Results: Of the 6814 screening-eligible women included in …

Improvement And Maintenance Of Clinical Outcome Assessments In Atopic Dermatitis With Amlitelimab, Andrew Blauvelt, Raj Chovatiya, Joseph F Merola, Stephan Weidinger, Ken Igawa, Christine Weber, Cori Gray

Faculty, Staff and Student Publications

Background: Amlitelimab, a fully human, nondepleting, anti-OX40 ligand monoclonal antibody, demonstrated reductions in lesional and pruritic endpoints in adults with moderate-to-severe atopic dermatitis (AD) in phase 2a and 2b trials.

Objectives: Here, we examined the effect and durability of amlitelimab on clinical outcome assessments (COAs) in the randomized STREAM-AD phase 2b trial.

Methods: Adults with moderate-to-severe AD with prior inadequate response to or inadvisability of topical medications received subcutaneous amlitelimab (250 mg with 500-mg loading dose, 250 mg, 125 mg or 62.5 mg) or placebo every 4 weeks in Part 1 (Weeks 0-24; 1:1:1:1:1 randomization). In Part 2, Week 24 …

Acculturation, Values, And Acculturative Stress For Autistic Latino Emerging Adults And Spanish-Speaking Parents Participating In The ¡Iniciando! La Adultez Program, Antonio F Pagán, Miriam Ortiz, Erin Bernal, Katherine A Loveland, Ana Esparza, Cecilia Montiel-Nava, Ron Acierno

Faculty, Staff and Student Publications

Latino families with emerging adults diagnosed with Autism Spectrum Disorder (ASD) face unique challenges during the transition to adulthood, influenced by cultural values, acculturation, and systemic barriers. Acculturation and acculturative stress are particularly relevant in this population, as they navigate cultural adaptation while maintaining traditional values like familismo (family) and respeto (respect). These dynamics are further complicated by disparities in access to resources and culturally responsive interventions. This study explores the interplay of cultural values, acculturation, and acculturative stress among Latino emerging adults with ASD and their Spanish-speaking parents participating in a culturally adapted and translated intervention. Using a cross-sectional …

Help-Seeking Among Early Adolescents Who Use Physical Peer Violence, Kelli Franco, Elizabeth Baumler, Leila Wood, Heidi Adams Rueda, Jeffrey R Temple

Faculty, Staff and Student Publications

Despite accumulating research on help-seeking among violence victims, little is known about help-seeking among youth who use violence. In a racially and ethnically diverse sample of early adolescents (N=2,676; 50.3% female; Mage=12.67), participants self-reported physical bullying, physical fighting, physical dating violence perpetration, and help-seeking intentions over the past year. T-tests and one-way ANOVAs examined help-seeking by sex and race, respectively. Prevalence and comparisons of help-seeking across youth with and without any violence were examined. Youth who used any physical peer violence (n=965) reported lower help-seeking intentions than their peers, and among violent youth, males reported …

Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells For Parkinson's Disease: A Randomized Trial., Mya C Schiess, Jessika Suescun, Juan D Martinez-Lemus, Charles Green, Tia S Thomas, Mohammad Shahnawaz, Emily Tharp, Nikunj B Satani, Jerome G Saltarrelli, Christopher Adams, Marie-Francoise Doursout, Vanessa Thyne, Rula Abuamouneh, Elsa M Rodarte, Sean I Savitz, Timothy M Ellmore

Faculty, Staff and Student Publications

Background: Neuroinflammation contributes to Parkinson's disease (PD) progression and motor dysfunction. Allogeneic human mesenchymal stem cells (allo-hMSCs) may reduce neuroinflammation and improve motor symptoms.

Objectives: To evaluate the efficacy of repeated intravenous doses of 10 × 106/kg allo-hMSCs in improving motor symptoms in patients with PD (PwP).

Methods: In this phase 2, randomized, placebo-controlled trial (November 2020-July 2023), mild-to-moderate PwP received either three allo-hMSC infusions, one placebo followed by two allo-hMSC infusions, or three placebo infusions at 18-week intervals. Follow-up lasted 88 weeks. The primary outcome was a >70% posterior probability (PP) of a difference in the proportion of participants …

Efficacy Of Platelet Rich Plasma Versus Placebo For Improvement In Olfactory Function In Adults With Olfactory Dysfunction: A Systematic Review And Meta-Analysis, Ali B Jafar, Ghabrielle Almeida, Fatima Al Mousawi, Eric Delgado Rendon, Amber U Luong

Faculty, Staff and Student Publications

Background: Olfactory dysfunction significantly impairs quality of life. Conventional treatments such as corticosteroids and olfactory training offer limited and inconsistent efficacy. Platelet-rich plasma (PRP), a biologically active agent, has shown potential regenerative effects in olfactory neuroepithelium. This study systematically evaluates the efficacy of PRP compared to placebo in improving olfactory function.

Methods: A systematic review and meta-analysis was conducted according to PRISMA guidelines and was registered in PROSPERO (CRD 420251045079). The databases searched included PubMed, Scopus, Embase, Central, and Web of Science. Seven studies (four RCTs, three non-RCTs) involving 789 patients were included. Subjective and objective outcomes were extracted and …