Digital Commons Network^™

Defense Wins Championships (And Labor Disputes): How The Minor Leagues Can Field Their Position Against Mlb’S ‘Inside Baseball', Blake Morain

Vanderbilt Law Review

For years, minor league baseball players received salaries far below the federal minimum wage, despite working sixty hours per week. It was not uncommon for these professional athletes to share cramped hotel rooms, sleep on floors, or live out of their cars. Most had to secure loans and pursue odd jobs to make ends meet during the offseason. Such sacrifices were necessary for minor leaguers to achieve their dreams of reaching the major league level, particularly as those abysmal working and living conditions became entrenched by adverse legislation and judicial rulings.

Only within the last five years have minor leaguers …

Pembrolizumab In Patients With Advanced Miscellaneous Rare Cancers: Results From A Phase 2 Basket Trial, Mirella Nardo, Camila Braganca Xavier, Bettzy Stephen, Jeffrey A How, Justin Moyers, Vivek Subbiah, David S Hong, Aung Naing

Faculty, Staff and Student Publications

Introduction: Rare solid tumors account for one-quarter of cancers among adults in the United States, but few resources have been devoted to their treatment. We evaluated the efficacy of pembrolizumab, a programmed cell death-1 inhibitor, in patients with rare solid tumors.

Methods: We conducted a phase 2 basket trial that included patients with rare, advanced tumors. Patients were enrolled in the study in nine tumor-specific and a 10th cohort of miscellaneous rare histologies. Patients received pembrolizumab 200 mg intravenously every 21 days. The primary endpoint was the non-progression rate at 27 weeks per immune-related Response Evaluation Criteria in Solid Tumors …

Multiparametric Mri Scoring System Of The Pancreas For The Diagnosis Of Chronic Pancreatitis, Temel Tirkes, Dhiraj Yadav, Darwin L Conwell, Xuandong Zhao, Anil K Dasyam, Vivek Gowdra Halappa, Aashish Patel, Zarine K Shah, Jordan Swensson, Naoki Takahashi, Sudhakar Venkatesh, Ashley Wachsman, Liang Li, Kristofer Jennings, Yunlong Yang, Phil A Hart, Stephen J Pandol, Walter G Park, Santhi Swaroop Vege, Mark Topazian, Paul R Territo, Scott A Persohn, Dana K Andersen, Evan L Fogel, Consortium For The Study Of Chronic Pancreatitis, Diabetes, And Pancreatic Cancer (Cpdpc)

Faculty, Staff and Student Publications

Background: Ductal features alone may not offer high diagnostic sensitivity or most accurate disease severity of chronic pancreatitis (CP).

Purpose: Diagnose CP based on multiparametric MRI and MRCP features.

Study type: Prospective.

Population: Between February 2019 and May 2021, 46 control (23 males, 49.3 ± 14.1 years), 45 suspected (20 males, 48.7 ± 12.5 years), and 46 definite (20 males, 53.7 ± 14.6 years) CP patients were enrolled at seven hospitals enrolled in the MINIMAP study. CP classification was based on imaging findings and clinical presentation.

Field strength and sequences: 1.5 T. T1-weighted (T1W) spoiled gradient echo, T1 map with …

African Sleeping Sickness: From Basic Biology To Future Directions, Riddhi R. Patel

All Theses

African Sleeping Sickness is a Neglected Tropical Disease (NTD) which poses a significant health risk to impoverished populations in 36 Sub-Saharan African countries. It is a devastating disease caused by the protozoan parasite Trypanosoma brucei, which is transmitted to mammals via the bite of infected tsetse flies. The disease manifests in two stages: the hemolymphatic stage and the meningoencephalitic stage. In the latter stage, it invades the Central Nervous System (CNS) and can be fatal if left untreated. It is caused by morphologically indistinguishable species of Trypanosoma brucei in both humans and animals, where in humans it is known as …

Standardized Classification Of Infants With Robin Sequence Using Micronaps: The Impact Of Syndromes And Comorbidities., Cory M. Resnick, Jody E. Heffernan, Snigdha Jindal, Zaara Mehra, Irfan Ahmad, Bimal Chaudhari, Christopher Cielo, Nicole Deptula, Zarmina Ehsan Md, Kelly N. Evans, Semsa Gogcu, Scott E. Hickey, Jeffrey S. Marschall, Maithilee Menezes, David Molter, Michael A. Padula, Stacey L. Peterson-Carmichael, Stephen Alex Rottgers, Christopher M. Runyan, Jordan W. Swanson, Tara L. Wenger, Andrew Deek

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: MicroNAPS, a classification for infants with Robin sequence (RS) intended to guide treatment decisions, consists of 5 elements: micrognathia, nutrition, airway, palatal clefting, and syndromes/comorbidities. Scoring of the first 4 elements is well defined, but the assignment of the syndromes/comorbidities score (S score) introduces subjectivity by necessitating judgment regarding the clinical impact of the diagnosis. A database of comorbid diagnoses associated with RS and consensus-based S scores for each is needed for the MicroNAPS system to be reproducible.

METHODS: Diagnoses known to be associated with RS were identified from existing literature, and preliminary severity grades were applied. A series …

Labour Companionship And Respectful Treatment Of Women During Childbirth: A Cross-Sectional Study Across 16 Hospitals In Benin, Malawi, Tanzania And Uganda, Soha El-Halabi, Kristi Sidney Annerstedt, Christian Agossou, Fadhlun Al-Beity, Andrea B. Pembe, Phillip Wanduru, Bianca Kandeya, Jean-Paul Dossou, Helle Molsted-Alvesson, Claudia Hanson

Centre of Excellence in Women and Child Health

Introduction: Evidence suggests that women value and benefit from having a labour companion during childbirth. However, the applicability of the evidence to low-income and lower-middle-income countries is limited and varies. Thus, we assessed the association between the presence of labour companions and mistreatment in 16 hospitals of Benin, Malawi, Tanzania and Uganda.

Methods: We conducted a cross-sectional survey using a validated questionnaire administered to women at discharge after birth between December 2021 and March 2024. The main outcomes were factor-weighted respectful treatment score and its subscores on maintained respect and dignity, privacy and maintained confidentiality and no physical and verbal …

Harnessing Edna Metabarcoding To Monitor Species Diversity In Restoration Sites: Insights From Laikipia, Kenya, Cornelius Okello, Nina Wambiji, Susana W. Kihia, Nehemiah Ongeso, Samuel Mwakisha Mwamburi, Anthony Wandera, Marie Estelle Demory, Margaret Awuor Owuor

All Peer-Reviewed Publications

Restoration of degraded arid and semi-arid lands (ASALs) dryland ecosystems gained traction globally with the enactment of the Bonn Challenge and UN Decade of Restoration. This has been domesticated in Kenya's context by The Forest and Landscape Restoration Implementation Plan (FOLAREP). However, effectively monitoring restored ecosystems is crucial but challenging because of data gaps and technical hurdles, highlighting the need for innovative approaches to assess and restore biodiversity. This study aimed to pilot soil environmental DNA (eDNA) metabarcoding to detect species compositions rapidly, evaluate population structures and abundances, and characterize taxonomic groups. The results from this study serve as a …

Influence Of Colony And Hive Attributes, Landscape, And Seasonality On Occurrence Of Large Hive Beetles (Coleoptera: Scarabaeidae) In Taita Taveta County, Kenya, Mbatha B. Wambua, Ayuka T. Fombong, Kiatoko Nkoba, Gladys K. Onyambu, Helen Lydiah Kutima, Sevgan Subramanian, Beatrice T. Nganso

All Peer-Reviewed Publications

Recently, an unexpectedly large number of large hive beetles, Oplostomus haroldi (Witte), was observed in Taita Taveta County (TTC), Kenya, suggesting a potential threat to the apicultural industry. This study investigated the influence of colony and hive attributes, landscape characteristics, and seasonality on the occurrence of O. haroldi within beehives in TTC. Field surveys assessed beetle populations alongside colony strength parameters, environmental variables, and hive types using standard protocols. Our findings revealed significant positive correlations between beetle occurrence and colony phenotypes, such as capped brood, pollen, and honey quantities. Higher beetle populations were also observed in areas with tree cover …

Long-Term Cropping System And Manure Effects On Soil Health Parameters And Associated Soil-Borne Pathogens, Joyce Mutai, Beth Medvecky, Steven J. Vanek, John Ojiem, Peter Bolo, Job Kihara, Steven J. Fonte

All Peer-Reviewed Publications

Soil-borne pathogens reduce the performance of key food crops in sub-Saharan Africa. Diversified cropping and nutrient management can enhance soil and plant health, limiting pathogen damage. To examine how management and soil health changes influence soil-borne pathogens, we leveraged an 18-year field trial in western Kenya, evaluating cropping systems typical of smallholder farms. We considered three cropping systems and two organic matter management strategies: continuous maize monocrop (M–M), Tephrosia in rotation with maize (T–M), maize intercropped with soybean (M–S), application or not of farmyard manure, and retention or removal of crop residues. We assessed soil physical and chemical properties and …

Summit Disease: The Ecological Horror Of Empire, Nicholas Moore

Theses

This project focuses on the use of insect imagery in art and media and the theories and concepts that have been instrumental in understanding the cultural and political significance of insect species extinction and decline. I center my work on the concept of ecohorror and highlight several artists whose work depicts insect species and conveys anxieties over ecoprecarity and climate dysfunction. I argue that depictions of insects in art and media can be interpreted in two ways - insects as destructive, monstrous contaminants and insects as constructive, beneficial terraformers - and I rely on Hayao Miyazaki’s Nausicaa of the Valley …

Hope After Grief And Loss: A Needs Assessment Of Peer-Led, Non-Denominational Bereavement Support Services At Laurel’S Grief Center, Julia A. Lange

Public Administration Master’s Projects

This needs assessment examines the grief support services provided by Laurel’s Grief Center (LGC), a nonprofit organization in Buffalo, New York, and identifies opportunities to expand tailored services for grieving adults in Western New York. Using a convergent mixed-methods design, this study collected data through semi-structured interviews with LGC board members and surveys with clients and peer volunteers. Key findings highlight the importance of peer-led, non-denominational grief support and creative approaches, such as art therapy, while identifying barriers, such as stigma, limited awareness, and fragmented regional services.

Based on these findings, this study recommends expanding healing arts programs, enhancing outreach …

The Effect Of Food Preference On The Efficacy Of The High-Probability Instructional Sequence To Treat Food Selectivity, Christina Marie Sheppard

Theses and Dissertations

Food selectivity involves avoiding certain foods based on type, texture, brand, smell, temperature, or presentation, and it affects 80% of children with intellectual and developmental disabilities. Although several antecedent-based and consequence-based behavioral interventions exist to increase acceptance and consumption of food in this population, one antecedent-based intervention that has shown promise both within and outside of a feeding context is the high-probability instructional sequence, which consists of the delivery of three high-probability instructions before delivery of a low-probability instruction. The high-probability sequence is used to increase compliance with instructions that have a low probability of completion (e.g., taking a bite …

Exploring The Relationship Between Suicidal Behavior And Obesity Among Young Hispanic Adults In The United States, Nadeen Salhadar

Theses and Dissertations

The rates of obesity and suicidal behavior have continued to increase over the years among young adults in the United States. Previous research has indicated a relationship between obesity and suicidal behavior, primarily among women, yet minimal research has been done to examine factors that explain this relationship (i.e., mediators). This study investigated the role of depression, body dissatisfaction, body shame and guilt, insomnia, physical health, and social anxiety on obesity and suicidal ideation among 209 college-aged Latina women. The researcher hypothesized that there would be an indirect relationship between obesity and suicidal behavior through multiple variables. Mediation analyses via …

Constructing An Attractive Targeted Sugar Bait For Reducing Mosquito Populations, Xi Xian Ng

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Mosquito-borne pathogen transmission continues to pose a significant burden to global public health, well-being, and economic productivity. In the absence of universally available vaccines and amidst rising insecticide resistance that leads to product failures, there is an urgent need to develop new tools to mitigate mosquito-borne disease risk. Two general strategies exist to reduce transmission risk: personal protective measures and area-wide chemical interventions. Attractive Targeted Sugar Bait (ATSB) systems leverage the sugar-feeding behavior of mosquitoes—critical for sustaining their flight, metabolism, development, and fecundity—by delivering oral toxicants through attractively formulated sugar baits. This study aimed to develop an optimized ATSB formulation …

Youth Sport Participation And Cognitive Development: The Need For Improved Measurement, Amelia Anne Miramonti

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Background: Youth sport participation is associated with numerous positive developmental outcomes, including potential cognitive benefits. However, research examining sport-cognition links often uses simplistic operationalizations of sport participation and cross-sectional designs, limiting causal inference and understanding of specific sport characteristics' roles. This study aimed to develop and compare a novel, nuanced sport participation scoring method against common operationalizations in predicting cognitive outcomes in a large youth sample, while controlling for general physical activity and health as a first step towards more robust longitudinal analyses.

Methods: Data were drawn from the Adolescent Brain Cognitive Development (ABCD) Study Year 2 follow-up …

Sheep And Goat Industry Funding Scheme 2023-24 Annual Report, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity published reports

I am pleased to present the 2023-24 annual report for the Sheep and Goat Industry Funding Scheme (Sheep and Goat IFS) to our participants, key stakeholders in the Western Australian (WA) sheep and goat industry, and the Minister for Agriculture and Food.

The WA sheep and goat industry has faced a challenging year. After a period of relative stability between 2010 and 2019, the WA flock has continued to decline since 2020, reaching its lowest point since 1952. This downward trend is expected to continue due to local factors such as increased turn-off and seasonal conditions, further compounded by political …

Local Systems Change: Applied Research Methods For Sustainable Communities, Taylor Barrett Hill

Graduate Student Portfolios, Professional Papers, and Capstone Projects

No abstract provided.

Translation Of The Carcinogenic Dna Breakage-Repair Inhibition Mechanism For Hexavalent Chromium To Its Key Targets: Lung Epithelial Cells, Lung Tissue And Impacts On The Genome., Idoia Meaza Isusi

Electronic Theses and Dissertations

Lung cancer is the leading cause of cancer death worldwide. Hexavalent chromium [Cr(VI)] is a human lung carcinogen with widespread occupational and environmental exposure. Despite the known health risks, how Cr(VI) causes lung cancer remains unclear. This dissertation investigates the mechanisms of Cr(VI)-induced carcinogenesis. Cr(VI) causes DNA damage, specifically DNA double strand breaks, and inhibits homologous recombination repair, a high-fidelity repair pathway. Unrepaired DNA double strand breaks or those repaired through error-prone pathways, progress to chromosomal damage, and chromosome instability. The latter is a common characteristic of Cr(VI)-exposed cells, and a hallmark of lung cancer. Although the mechanism of Cr(VI)-induced …

Analyzing The Association Of Competitive Food Policy On Competitive Food Content In U.S. Schools., Mary E. Curnutte

Electronic Theses and Dissertations

OBJECTIVES: School food can have a profound effect on the population’s health. Thirty million children receive food at school and consume half their daily calorie intake at school. Competitive foods are foods sold outside of school breakfast and lunch, such as those sold in vending machines. A new ruling for Smart Snacks Standards, a set of competitive food guidelines, started in the school year 2014-2015. It is known that competitive foods undermine school lunch participation, and a decrease in school lunch consumption is associated with poorer student health. Additionally, an increase in competitive foods tends to be of nutrient-poor …

The Effects Of Geographic Isolation And Anthropogenic Activity On The Social Behavior Of Caribbean Green Monkeys., Rose Amrhein

Electronic Theses and Dissertations

Green monkeys (Chlorocebus sabaeaus) arrived to the Caribbean with the Trans-Atlantic slave trade. Since then, they have experienced unique environments to those of their native ranges in West Africa. Additionally, recent taxonomic changes within the genus make previous knowledge about the species hard to determine to be accurate. In this dissertation, I both assess some of the effects the island environment may have had on monkey behavior as well as build on the understanding of their vocal communication across three islands: Barbados, St. Kitts, and St. Martin. In chapter one, I investigate how human activity in Barbados affects …

Long-Term Changes In Bolus Parameters During Swallowing Post-Chemoradiation Treatment., Brittany Rebecca Smiley

Electronic Theses and Dissertations

Current treatment for oropharyngeal cancer involves chemoradiation, which can have profound effects on swallowing function. Submental muscle activity is critical for airway protection and bolus transit but is highly susceptible to radiation-related swallowing impairments. This study examined whether chemoradiation targeting the submental muscles leads to measurable changes in esophageal distension during swallowing in a rodent model. We hypothesized that rats receiving chemoradiation would exhibit aberrant esophageal distension compared to chemotherapy-only controls. Twenty male rats underwent four cycles of cisplatin concurrently with either radiation or sham radiation. High-speed videofluoroscopy swallow studies were conducted pre- and post-treatment with thin liquids to analyze …

Mechanisms Of Particulate Hexavalent Chromium-Induced Inhibition Of Homologous Recombination Repair: Targeting The Bcdx2 Complex Considered Through A One Health Perspective., Aggie W. Brownell

Electronic Theses and Dissertations

Lung cancer remains the leading cause of cancer death, often linked to smoking. However, smoking alone does not account for all cases. Exposure to environmental metals like hexavalent chromium [Cr(VI)] also contributes to lung cancer. Cr(VI) causes lung cancer by inducing chromosome instability (CIN), an early hallmark of its carcinogenic mechanism. While it has been established that Cr(VI) induces chromosome instability, the precise mechanisms underlying the chromosome instability are poorly understood. This dissertation investigates the mechanisms of carcinogenesis associated with zinc chromate, a particularly potent particulate form of hexavalent chromium. Studies show Cr(VI) induces DNA double-strand breaks and impairs the …

Seeding Rate, Planting Date, And Herbicides For Dormant Seeded Safflower In Utah, Rodney Daniel Nelson

All Graduate Theses and Dissertations, Fall 2023 to Present

Dryland crop production in the Intermountain West is largely limited by the amount of precipitation received. Increasing dryland safflower (Carthamus tinctorius L.) production yields in a semi-arid climate is possible with a dormant planting but is not well understood. A two-year (2020-22) project was designed to gain an understanding of the effects of variety, seeding rate, and planting date, on dormant seeded safflower. Chemical weed control options for safflower were also evaluated. One study, conducted at three Utah State University research farms near Blue Creek, Clarkston, and Kaysville, UT, evaluated four varieties, S-208, S-333, 7325 and Hybrid-446, seeded at …

Seasonal And Temporal Influences On Successful Crossing Rates By Ungulates Of A North Utah Wildlife Overpass, Blake Ledbetter

All Graduate Theses and Dissertations, Fall 2023 to Present

Encroachment of human infrastructure fragments wild landscapes and introduces a suite of negative impacts for humans and wildlife. In Utah, roadways threaten migratory ungulates by creating a barrier to movements and preventing access to seasonal migration routes. To mitigate these conflicts, state transportation agencies often install wildlife crossing structures to allow animals to safely cross over or under roadways. Selecting the proper crossing structure requires consideration of the species of interest, landscape, location, and structural dimensions. Often there is balance between the optimal location, the dimensions of the crossing structures, and what is feasible given the landscape. In 2018, the …

Novel Horticultural Approaches For Reduced Gravity And Controlled Environment Agriculture, Sarah Elizabeth Schreck

All Graduate Theses and Dissertations, Fall 2023 to Present

On July 16, 1969, Apollo 11 achieved the first successful moon landing, marking a significant milestone in human space exploration. This historic moment effectively ended the space race between the United States and the Soviet Union, and since then, countries around the world have continued to advance their space programs. While the space race has evolved, the next major challenge lies in sending humans to Mars—a journey that could take 6 to 9 months each way, presenting numerous challenges, including the critical issue of nutritional sustainment for the crew.

This thesis addresses key aspects of a broader effort to support …

Uv-A Light And Heat-Activated Antimicrobial And Biodegradable Materials For Food Packaging And Preservation, Michael J. Bodily

All Graduate Theses and Dissertations, Fall 2023 to Present

Current food packaging materials are often non-biodegradable and harmful for ingestion, which poses a threat to the environment and public health. Thus far, the dangers of microbial contamination of food on human health have outweighed the risks associated with using these conventional packaging plastics. A possible solution to these issues is to use a combination of innovative materials and microbial inactivation methods that can potentially both reduce plastic waste and combat harmful microorganisms. In this study, two antimicrobial, biodegradable composites were developed and tested for their ability to inactivate two types of bacterium, Escherichia coli K12 and Listeria innocua, …

Optimizing Nutrient Recycling To Achieve Zero–Discharge Management For Controlled Environment Agriculture, Noah James Langenfeld

All Graduate Theses and Dissertations, Fall 2023 to Present

Controlled environment agriculture (CEA) allows for human control of one or more environmental factors affecting crop production. Optimizing nutrient management in such systems allows for translation and predictions of sustainable management strategies in the field. These systems will be used to supply fresh food as public and private space agencies are planning to send humans to the Moon and Mars in the near future. Food resupply becomes increasingly difficult as the distance from Earth increases. Plants can be grown off-Earth as a food source, but their growth must be carefully managed to ensure long-term sustainability. I describe a model used …

Effects Of Plant Biostimulants On Onion Growth And Production Under Greenhouse And Field Conditions, Prakriti Nepal

All Graduate Theses and Dissertations, Fall 2023 to Present

The escalating impact of climate change on agricultural production underscores the need to investigate sustainable crop enhancement methods. This research explores the use of plant biostimulants to grow onion (Allium cepa L.) under varying environmental conditions. In the initial germination and greenhouse screening, seven biostimulants were tested on ‘Vaquero’ onion seeds: three bacterial products (Continuum, Spectrum DS, and Tribus Original), two mycorrhizal products (Mighty Mycorrhizae and Myco Apply), one seaweed extract product (Seaweed), and one product containing humic acid (Huma Pro 16). Mighty Mycorrhizae, Continuum, and Myco Apply supported faster germination, while seeds treated with Spectrum and Seaweed took …

The Effect Of Dietary Protein Source On Gut Health, Spencer Lawson Schow

All Graduate Theses and Dissertations, Fall 2023 to Present

We investigated the impact of protein source in a western-style diet on colon cancer, colitis, and the gut microbiome. The Western dietary pattern is energy-dense, low in fiber, and has a sub-optimal micronutrient profile. Our group has formulated the Total Western Diet (TWD) that emulates the Western dietary pattern using survey data (NHANES), and we have demonstrated that this diet increases gut inflammation and colorectal cancer relative to a healthy control diet (AIN-93G), which is optimized for mouse health. However, the effect of protein source in the TWD and its effects on gut health have yet to be investigated.

Recent …

School Counselors’ Lived Experiences During The Covid-19 Pandemic, Katie M. Guzman Dunn

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to understand how school counselor perceptions of their roles may have been permanently impacted by the COVID-19 pandemic. Bronfenbrenner’s (1979) Ecological Systems Theory, which relates to the interactions of an individual and the environment around them, guided the study. The study’s central research was: What are public school counselors’ lived experiences regarding their role perception during the COVID-19 pandemic? Data was collected through virtual semi-structured interviews and photo elicitation with 10 school counselors who were members of the Kentucky School Counselor Association. The data collected from the interviews was analyzed using bracketing to …