Restricting Outdoor Advertising Of Unhealthy Food: Can Australia's Food Category-Based Classification System Be Applied Consistently?, Clare Whitton, Frith Klug, Alexia Bivoltsis, Georgina S.A. Trapp, Claire E. Pulker

Research outputs 2022 to 2026

Most outdoor food advertising (e.g. billboards and bus stops) features foods that are considered unhealthy. The most important technical challenge when designing policies to restrict unhealthy outdoor food advertising is defining 'unhealthy food'. To date, most restriction policies have used nutrient profiling models (i.e. foods are classified according to their nutritional composition) to determine which foods and beverages may be advertised. In Australia, state governments have endorsed a food category-based classification system, with no prescribed nutrient limits, which may create ambiguity when multiple users are identifying food advertisements to be restricted. This study aimed to assess the consistency of decisions …

Examining The Lived Experiences Of International Students At East Tennessee State University, John The Baptist Anodjo

Electronic Theses and Dissertations

This research investigates the lived experiences of international students at East Tennessee State University (ETSU), specifically examining how they navigate social, academic, and structural challenges. Through in-depth interviews with 20 international students from a variety of nationalities, I analyzed issues related to legal status, housing, food insecurity, healthcare, and social integration. I found that students encounter barriers due to immigration policies, financial constraints, and limited access to essential resources. Additionally, international students benefit significantly from support provided by campus services, community organizations, and their social networks, which play a vital role in their adjustment process. While institutional resources are beneficial …

Investigating The Impact Of Psychoactive Plant Alkaloids On Bumblebee Behavior, Skylar Mathieson

Electronic Theses and Dissertations

The relationship between plants and their pollinators is often framed as a food-for-service exchange in which plants provide pollinators with nutrients in exchange for transport of their gametes. However, in addition to essential nutrients, many floral rewards (nectar, pollen) also contain defensive toxins such as alkaloids, with largely unexplored consequences for plant-pollinator interactions. I investigated how three psychoactive and addictive plant alkaloids — caffeine, nicotine, and morphine — affect foraging behavior in generalist bumblebees (Bombus impatiens) using robotic flowers. Each of these chemicals affected pollinator foraging behavior, influencing the number and duration of their visits to flowers in …

Investigating The Multiple Enzyme Complex In The Carotenoid Biosynthesis Pathway, Mercy Mormor

Electronic Theses and Dissertations

In nature, plant carotenoids are 40-carbon isoprenoids with polyene chains that may have double bonds. They are vital components of all photosynthetic organisms, playing several roles in the plant cell, including photosynthesis, pigmentation, phytohormone synthesis, signaling and photoprotection. In this study, we investigated protein-protein interactions among key enzymes involved in the carotenoid biosynthesis pathway using the Bimolecular Fluorescent Complementation (BiFC) assay. Our results revealed several interactions that suggest a coordinated regulation of enzymatic activity within this pathway, highlighting potential regulatory complexes that influence carotenoid production. The study also highlights the pivotal role of Zeta-Carotene Isomerase (Z-ISO) as a key regulatory …

Drivers And Consequences Of Changes In Nectar Microbiome Composition Across Spatial And Biological Scales, Daniel A. Barker

Electronic Theses and Dissertations

Microbial communities inhabiting floral nectar, known as the nectar microbiome, are important mediators of plant-pollinator interactions. However, the ecological and environmental factors that shape the composition of these microbial communities remain poorly understood. While previous studies have examined the effects of a few microbial groups, typically independent of one another, on one plant or pollinator species, this dissertation takes a wide-scale approach to explore how abiotic conditions and biotic interaction’s structure microbial communities within floral nectar. Furthermore, I also quantify how variation in microbial richness and identity influences pollinator behavior and plant reproductive success.

This dissertation shows that microbial abundance …

Construct And Predictive Validity Of The Kansas City Cardiomyopathy Questionnaire In Adult Congenital Heart Disease, Ryan D Byrne, Ajith P Nair, Stephen J Dolgner, Swati Choudhry, Edward J Hickey, Alexis C Wood, Savitri Fedson, Biykem Bozkurt, Christopher R Broda

Faculty, Staff and Students Publications

Background: The Kansas City Cardiomyopathy Questionnaire (KCCQ) is an Food and Drug Administration-approved health status measure for patients with heart failure (HF) but has not been directly assessed in adult congenital heart disease (ACHD).

Objectives: This study evaluates construct and predictive validity of the KCCQ in ambulatory ACHD patients.

Methods: We performed cross-sectional and prospective cohort studies of ACHD patients who completed the KCCQ to assess construct and predictive validity, respectively. KCCQ scores were compared across ACHD complexity categories, disease characteristics and physiologic failure, and within 2 primary composite outcomes: death or all-cause hospitalization (DH) and death or interventional cardiac …

Two Essays On The Role Of Anthropomorphism In Consumer Behavior, Faegheh (Faa) Taheran

Theses and Dissertations in Business Administration

The first essay of this dissertation investigates the contradictory findings on the relationship between anthropomorphism and self-control by focusing on how everyday anthropomorphized objects, rather than the products being used for consumption, influence consumer behavior. While previous studies have shown that using anthropomorphized products may decrease consumers’ self-control, this paper examines how unrelated [to consumption] anthropomorphized objects in a consumer’s environment—such as a water bottle with a humanlike face—can evoke a sense of social presence, increasing consumers’ perceptions that they are being negatively evaluated. Drawing on mind perception theory, I propose that this fear of negative evaluation can enhance self-control. …

Trophic Roles And Climate-Driven Vulnerability For Benthic Invertebrates At Artificial Reefs In The Northern Gulf Of Mexico, Amanda Kirkland

LSU New Orleans Theses and Dissertations

Artificial reefs are deployed to enhance marine habitats and fisheries, yet their role in supporting secondary production and their vulnerability to climate stressors remain understudied. This dissertation investigates the trophic ecology and climate sensitivity of benthic invertebrates at artificial reefs in the northern Gulf of Mexico. Chapter 1 assessed reef food webs using stable isotopes from fishes, invertebrates, and primary producers across six reefs and two seasons. Mixing models showed that most fishes rely on benthic reef carbon, while suspension feeders consume plankton and sediment microphytobenthos. Isotopic niche analysis revealed functional diversity and seasonal shifts in δ¹³C and δ³⁴S, though …

Celebrating The Fifth Edition Of The International Symposium On Fungal Stress – Isfus, A Decade After Its 2014 Debut, Alene Alder-Rangel, Amanda E A Rangel, Arturo Casadevall, Asiya Gusa, Chaoyang Xue, Charles M Boone, Chris Todd Hittinger, Claudio A Masuda, Consuelo Olivares-Yañez, Deborah Bell-Pedersen, Erica J Washington, Gerhard Braus, Guilhem Janbon, István Pócsi, Jason E Stajich, Jay C Dunlap, Joan W Bennett, Joseph Heitman, Ling Lu, Lucia Landi, Mari L Shinohara, Maurizio Del Poeta, Mavis A Acheampong, Mia R Maltz, Michael C Lorenz, Minou Nowrousian, N Louise Glass, Nichole A Broderick, Nicolás Pedrini, Nir Osherov, R Blake Billmyre, Sabrina Sarrocco, Salomé Leibundgut-Landmann, Vânia Aparecida Vicente, Xiaorong Lin, Xin-Qing Zhao, Yong-Sun Bahn, Zachary A Lewis, Drauzio E N Rangel

Faculty, Staff and Student Publications

The Fifth International Symposium on Fungal Stress (ISFUS) brought together in Brazil many of the leaders in the field of fungal stress responses, from fourteen countries, for four days of outstanding science ranging from basic research to studies with agricultural, medical, industrial, and environmental significance. In addition to the excellent oral and poster presentations, the Symposium organisers ensured that all participants had ample opportunity to engage, socialise, and network to exchange ideas and share research. The conference was enhanced by the world-class venue near Iguazu Falls, probably the greatest natural phenomenon in South America.

De-Escalating Local Therapies Without Compromising Outcomes: Lessons From The Collision Trial, Jessica Albuquerque, Noreen S Siddiqi, Van K Morris, Hop Tran Cao, Iwan Paolucci, Bruno C Odisio

Faculty, Staff and Student Publications

No abstract provided.

Optimization Of Mhealth Behavioral Interventions For Patients With Chronic Lymphocytic Leukemia: The Health4cll Study, Che Young Lee, Max J Gordon, Melissa M Markofski, Emily C Lavoy, Susan K Peterson, Liang Li, Sara Fares, Miranda Baum, Margaret Pace, Danielle Walsh, Alessandra Ferrajoli, Karen Basen-Engquist

Faculty, Staff and Student Publications

Purpose: This pilot study of a diet and physical activity intervention (HEALTH4CLL) was conducted to reduce fatigue and improve physical function (PF) in patients with chronic lymphocytic leukemia (CLL).

Methods: The HEALTH4CLL study used a randomized factorial design based on the multiphase optimization strategy (MOST). Patients received diet, exercise, and body weight management instructional materials plus a Fitbit and were randomized to undergo one of 16 combinations of 4 evidence-based mHealth intervention strategies over 16 weeks. Patients' fatigue, PF, health-related quality of life, behavior changes, and program satisfaction and retention were assessed. Paired t-tests were used to examine changes in …

Commodity Diversification, Technological Innovation, And Market Dynamics: Insights Into Beef Cattle Production And Feeder Cattle Basis In The United States, Nik Berg

All Theses

The beef cattle industry plays an important role in the agricultural economy, contributing to both domestic food supply and global trade. The United States is one of the world's largest producers of beef, with production systems varying widely across regions largely due to differences in available resources and market structures. Market conditions, technological advancements, and policy interventions shape the way producers operate, making research into these factors essential for both industry stakeholders and policymakers.

Producers are continuously adapting to changing economic conditions, environmental challenges, and evolving consumer preferences. By analyzing these factors, researchers can provide insights to support informed decision-making …

Effect Of Amino Acid Derivatives And Polyphenol Supplementation On Skeletal Muscle Growth In-Vitro And In-Vivo, Gabriella C. Iheanacho

All Theses

Background

Satellite cells (SCs) are myogenic precursor cells that play a crucial role in muscle growth, and their activity can be influenced by nutrient supplementation. Muscle growth can also be stimulated using growth-promoting hormones; however, there are no approved growth hormones for use in sheep in the United States (Qaid & Abdoun, 2022). This limitation highlights a need to identify alternative compounds that would serve as nutrient supplements to enhance muscle growth and thereby improve meat production. Amino acid derivatives such as guanidinoacetic acid (GAA) and 5-hydroxytryptophan (5-HTP), along with the polyphenol quercetin, are naturally derived compounds that have shown …

Life Cycle Assessment Of The Cultivation Of Lettuce In A Hydroponic System Using The Nutrient Film Technique, Raquel Jordan

All Theses

Hydroponic systems are an emerging method of soilless crop cultivation typically done inside a greenhouse where nutrients are delivered dissolved in water rather than being supplied from the soil. Potential benefits of hydroponic systems include reduced irrigation requirements, higher crop yield per area, and the ability to grow crops year-round in nontraditional areas such as urban settings, cold climates, and sites with contaminated soil. However, hydroponic systems tend to have high energy requirements for lighting and climate control, which can yield significant environmental impacts. To explore the environmental impacts of cultivating lettuce in a nutrient film technique (NFT) hydroponic system, …

Assessing Grafted Triploid Watermelon And Yellow Nutsedge Growth In Saline Agroecosystems, Joseph F. Bazzle

All Theses

In an effort to better understand how saltwater intrusion events will impact watermelon growers a field trial was conducted to study how saline irrigation water will impact weed growth and seedless watermelon productivity at a joint Clemson University and USDA ARS facility. Weed management has always been a hurdle in vegetable crop production systems, requiring extensive labor even in a conventional setup. For organic growers, often the only economical approach is a combination of mechanical weed control techniques, including plastic mulches, tarps, and hand weeding. For watermelon growers, plastic mulch remains the most effective form of organic weed control available. …

Determining The Impact Of Surface Roughness On Disinfection Efficacy Of Commercial Products Against Pseudomonas Aeruginosa And Staphylococcus Aureus Wet Surface Biofilms, Kayley Stallings

All Theses

Biofilms are resistant to many stressors including disinfectant treatments. Disinfection may be further complicated by biofilms formed on damaged surfaces, as the damaged parts provide bacteria a better place to attach and grow. To better understand the risks, a new method to standardize surface scratching, to emulate worn surfaces via surface roughness changes was developed. These surfaces were used to grow biofilms with an adapted standardized EPA method to determine disinfection efficacy differences on scratched and non-scratched high-density polyethylene (HDPE) and stainless steel (SS) coupons treated with commercial disinfectants [hypochlorite (CL)-based, hydrogen peroxide (HP)-based, and quaternary ammonium (QA)-based]. Post-80 grit …

Mammal Use Of Crossing Structures On Highways In The Southern Blue Ridge Mountains, Chloe E. Horton

All Theses

Road networks are a major driver of habitat fragmentation and wildlife mortality. Wildlife crossing structures (WCS) are a common mitigation strategy with the goal of maintaining landscape connectivity, reducing wildlife-vehicle collisions, and facilitating safe passage across highways. Most research on WCS prioritize large ungulates or carnivores, leaving potential gaps in our understanding of how diverse mammalian communities interact with these features. We investigated spatial, temporal, and behavioral patterns of small-, medium-, and large-bodied mammals using WCS in the southern Blue Ridge Mountains of North Carolina and Tennessee. Using remote camera data from structures on I-40 and I-26 collected from 2018 …

A Comparative Study Of Land Use Regulations And Impact On Coastal Estuaries, Mabel W. Dadzie

All Theses

The study presents a mixed method and longitudinal assessment of land cover change, estuarine land loss, and policy implemented to address the past and anticipated estuarine losses in the Cooper River and North and South Santee watershed over the past twenty years. This study uses National Land Cover Dataset from 2001 to 2021, NOAA’s SLR projection data and planning documents from 1990 to 2025 to examine policy evolution among ten major themes. The results illustrate significant changes in land cover, notably the transition of wetlands, agriculture, and forests to developed land, as well as an evident spike in the integration …

Life Cycle Assessment Of Sustainable Wastewater Systems - Algae-Based Wastewater Treatment, Harish Lakshmi Srinivasan

All Theses

This thesis studies the integration of an algae-based membrane bioreactor (MBR) and photobioreactor system into a domestic wastewater treatment facility, using the Clemson University WWTP as a reference plant. The proposed system replaces the conventional sequencing batch reactor and aerobic digester with a microalgae-bacteria symbiosis process, coupled with submerged ceramic membranes, an algal photobioreactor and anaerobic digestion for enhanced nutrient and energy recovery, which paves the way for water reuse and increased biological capacity in the future.

The study shows that overall energy consumption is reduced by approximately 18% compared to the existing conventional configuration. Further, methane production from anaerobic …

A Neutrosophic Cognitive Map-Based Modeling Framework For Analyzing The Indeterminate Impact Of Exercise On University Students’ Mental Health, Rui Wang

Neutrosophic Sets and Systems

No abstract provided.

The Microrna Mir-30a Blocks Adipose Tissue Fibrosis Accumulation In Obesity, Pradip K Saha, Robert Sharp, Aaron R Cox, Rabie Habib, Michael J Bolt, Jessica B Felix, Claudia E Ramirez Bustamante, Xin Li, Sung Yun Jung, Kang Ho Kim, Kai Sun, Huaizhu Wu, Samuel Klein, Sean M Hartig

Faculty, Staff and Student Publications

White adipose tissue (WAT) fibrosis occurring in obesity contributes to the inflammatory and metabolic comorbidities of insulin resistance and type 2 diabetes, yet the mechanisms involved remain poorly understood. Here, we report a role for the broadly conserved miRNA miR-30a as a regulator of WAT fibrosis and systemic glucose metabolism. Mice modified to express miR-30a at elevated levels in adipose tissues maintain insulin sensitivity coupled with reduced fatty liver disease when fed a high-fat diet. These effects were attributable to cell-autonomous functions of miR-30a that potently increase expression of adipocyte-specific genes. Proteomic screening revealed miR-30a limits profibrotic programs in subcutaneous …

Low-Dose Metformin Requires Brain Rap1 For Its Antidiabetic Action, Hsiao-Yun Lin, Weisheng Lu, Yanlin He, Yukiko Fu, Kentaro Kaneko, Peimeng Huang, Ana B De La Puente-Gomez, Chunmei Wang, Yongjie Yang, Feng Li, Yong Xu, Makoto Fukuda

Faculty, Staff and Students Publications

Metformin is the most commonly prescribed antidiabetes drug, yet its precise mechanism of action remains controversial. Previous studies have suggested that metformin acts peripherally by reducing hepatic glucose output and altering gut functions. Here, we report a neural mechanism via the small guanosine triphosphatase Ras-related protein 1 (Rap1). Mice with forebrain-specific Rap1 knockout exhibited resistance to the antidiabetic effects of low-dose metformin while remaining sensitive to other antidiabetic agents. Centrally administered metformin inhibited brain Rap1 and reduced hyperglycemia. Conversely, forced activation of brain Rap1 increased glycemia and abolished the glycemic effect of metformin. Metformin activated a specific subset of neurons …

Fluoride Toxicity And Benefit: An Integrated Review Of Mechanisms, Risks, And Public Health Impact, Sophia Chavarria

Graduate Student Dissertations, Theses, Capstones, and Portfolios

Fluoride has long been praised for its role in preventing dental caries, primarily through its effects on enamel remineralization and antibacterial effects. However, growing evidence from molecular and cellular studies suggests that excessive fluoride exposure, especially during tooth development, can lead to dental fluorosis and systemic toxicity. This paper examines the biological mechanisms underlying fluoride-induced dental fluorosis, with a focus on stress responses in ameloblasts, oxidative damage, impaired autophagy, and disrupted protein processing. It integrates data from in vitro, in vivo, and human studies to evaluate the cellular thresholds at which fluoride shifts from therapeutic to toxic. Systemic risks, including …

Effects Of Sediment Composition On Spartina Alterniflora And Juncus Roemerianus Productivity In Coastal Virginia: A Thin-Layer Sediment Placement Experiment, Caitlin Hemphill

Biological Sciences Theses & Dissertations

Climate change poses a major threat to the health of estuaries and their coastal wetland systems. The Chesapeake Bay’s coastal salt marshes are at high risk of inundation due to sea-level rise and land subsidence. Restoration techniques for maintaining coastal marsh resistance to sea-level rise are being developed and refined, with thin layer placement (TLP) emerging as a feasible solution in many areas of the United States. Despite TLPs use across the country, additional research is needed on species-specific responses, sediment types, and geographically focused studies in the lower Chesapeake Bay. My research addresses these gaps by combining both greenhouse …

Visceral, Neural, And Immunotoxicity Of Per- And Polyfluoroalkyl Substances: A Mini Review, Pietro Martano, Samira Mahdi, Tong Zhou, Yasmin Barazandegan, Rebecca Iha, Hannah Do, Joel Burken, Paul Ki-Souk Nam, Qingbo Yang, Ruipu Mu

Chemistry Faculty Research & Creative Works

Per- and polyfluoroalkyl substances (PFASs) have gained significant attention due to their widespread distribution in the environment and potential adverse health effects. While ingestion, especially through contaminated drinking water, is considered the primary route of human exposure, recent research suggests that other pathways, such as inhalation and dermal absorption, also play a significant role. This review provides a concise overview of the toxicological impacts of both legacy and emerging PFASs, such as GenX and perfluoro butane sulfonic acid (PFBS), with a particular focus on their effects on the liver, kidneys, and immune and nervous systems, based on findings from recent …

Optimization Of The Root Zone In Controlled Environment Agriculture, Brendan Fatzinger

All Graduate Theses and Dissertations, Fall 2023 to Present

Controlled environment agriculture (CEA) helps grow plants in spaces where resources like water and nutrients are limited, such as deserts or spacecraft. Effective management of water in the root zone, the area where plant roots grow, is vital to keeping plants healthy, especially in closed-loop systems where water cannot be wasted, as will be necessary for long-duration space missions.

An improved automated watering system designed for use in space-like environments was developed over several trials. Early designs using suction to draw water through tubes faced problems with uneven watering and roots blocking the tubes. Switching to a system that pushed …

Linking Variation In Mule Deer Nutritional Condition And Age To Population Performance In A Temperate Environment, Kent R. Hersey

All Graduate Theses and Dissertations, Fall 2023 to Present

The amount of body fat animals have as they enter and exit winter can have major impacts on how well they survive and reproduce. Mule deer are widely distributed herbivores whose survival and reproduction are strongly tied to weather patterns and the quality of vegetation they consume, which in turn impacts nutritional condition. The objective of this study was to identify and quantify the factors (animal specific, climatic, or habitat) influencing mule deer body fat during both summer and winter in Utah and examine how nutritional condition influences survival. We found December body fat was most affected by December lactation …

Ecology And Management Of Forest Grouse: Breeding Acoustic Monitoring, Spatial Behavior, And Harvest, Logan Clark

All Graduate Theses and Dissertations, Fall 2023 to Present

Forest grouse are difficult to study and manage in the Intermountain West because they live in remote, rugged areas and do not gather at predictable display sites like other grouse species. From 2023 to 2025, I studied two species, dusky grouse (Dendragapus obscurus) and ruffed grouse (Bonasa umbellus), to test new survey tools, track their seasonal movements, and evaluate hunting impacts.

First, I tested whether small audio recording devices placed in the forest could minimize labor needed for spring breeding surveys. To do this, I conducted traditional surveys with human observers at the same time and …

The Experience Of Latine Parents During Covid-19: Coping, Support, And Wellness, Jazmin Lara

All Graduate Theses and Dissertations, Fall 2023 to Present

Documentation status affects not just individuals, but entire family units. This project shares the voices of Undocumented Individuals and their Loved Ones (UnLOs), specifically Latine parents navigating multiple, overlapping stressors. Data was collected during a particularly challenging time marked by the COVID-19 pandemic and threats to the Deferred Action for Childhood Arrivals (DACA) program. Participants shared how they cope with stress, who they rely on for social support, how they practice wellness, and the type of community programming they would like to see more of. This research was possible through the collaboration between the Latinx Immigrant Health Alliance (LIHA) and …

Impacts Of 4r Nitrogen Management And Water Optimization On Soil Health, Kamaldeep Kamaldeep

All Graduate Theses and Dissertations, Fall 2023 to Present

Farmers in Utah and Idaho are facing growing challenges due to high fertilizer costs, limited irrigation water, and pressure to improve long-term soil health. To better understand current practices and grower attitudes, a survey was conducted in 2020 targeting 5,000 producers of small grains, corn, and potatoes. Although the response rate was low, 146 growers representing over 25,000 hectares of cropland participated. Survey results showed that most growers are open to improving nitrogen and irrigation practices and care about their soil health, even if not all are fully using 4R or precision agriculture methods.

This thesis includes two field studies …