Digital Commons Network^™

N-Acetylaspartate From Fat Cells Regulates Postprandial Body Temperature, Jessica B Felix, Pradip K Saha, Evelyn L De Groot, Lin Tan, Robert Sharp, Elizabeth S Anaya, Yafang Li, Holly Quang, Nooshin Saidi, Layla Abushamat, Christie M Ballantyne, Christopher I Amos, Philip L Lorenzi, Samuel Klein, Xia Gao, Sean M Hartig

Faculty, Staff and Students Publications

N-acetylaspartate (NAA), the brain’s second most abundant metabolite, provides essential substrates for myelination through its hydrolysis1. However, the physiological roles of NAA in other tissues remain unknown. Here, we show that aspartoacylase (ASPA) expression in white adipose tissue (WAT) governs blood NAA levels for postprandial body temperature regulation. Genetic ablation of Aspa in mice resulted in systemically elevated NAA levels, and the ensuing accumulation in WAT stimulated pyrimidine production. Stable isotope tracing confirmed higher incorporation of glucose-derived carbon into pyrimidine metabolites in Aspa knockout cells. Additionally, serum NAA levels positively correlated with the abundance of the pyrimidine …

Exploring The Long-Term Impact Of Dating And Family Violence On American Indian Youth And Adults: The Role Of Belongingness In Moderating Negative Effects, Racheal M. Killgore

All Graduate Theses and Dissertations, Fall 2023 to Present

Exposure to violence during childhood and adolescence is an important issue, particularly among Native Americans, who experience violence at higher rates compared to other racial/ethnic groups. This early exposure to violence can significantly affect future physical and mental health outcomes—including depression, substance abuse, suicide attempts, obesity, and premature death—while also shaping subsequent relationships in adulthood. Though widely studied in the general population, research focused on American Indians is lacking, with cultural contexts and factors uniquely shaping the experiences of those affected. In AI/AN communities, belongingness is important for well-being and, as such, is a relevant cultural factor that calls for …

Water Efficient Landscaping At Utah State University: Evaluating The "True" Value Of The Landscape Resiliency And Drought Plan, Mary Claire Jennings

All Graduate Theses and Dissertations, Fall 2023 to Present

Utah faces serious water challenges due to its dry climate, growing population, and inefficient water use. While most water conservation efforts focus on homes, businesses, and farms, state institutions like universities also play a role. As Utah’s land-grant university, Utah State University (USU) uses about 260 million gallons of water each year to irrigate its 180 acres of green space, with 92% of that water being used to irrigate grass landscapes. To promote sustainability and meet state water conservation policies, USU developed the Landscape Resiliency and Drought Plan (LR&DP) to create more drought-resistant landscapes. However, implementing water-saving strategies at state …

Precision Agriculture Applications In Tart Cherries: Yield Mapping Technologies And Remote Sensing For Water Stress Estimation, Anderson Luiz Dos Santos Safre

All Graduate Theses and Dissertations, Fall 2023 to Present

Tart cherry is an important specialty crop in the United States, particularly in Utah where the area dedicated to tart cherry cultivation is larger than any other fruit grown in the state. However, growers face increasing challenges due to rising land prices, limited water availability, and extreme weather events. These factors make it essential to adopt new technologies that improve efficiency and sustainability. Precision agriculture, which uses data-driven tools to manage crops more effectively, can help address these challenges. However, most tart cherry orchards still rely on traditional practices due to a lack of specialized technologies for this crop. This …

Habitat Selection Analysis Of Mule Deer To Determine Efficacy Of The Coyote Bounty Program In Utah, Xaela M. Walden

All Graduate Theses and Dissertations, Fall 2023 to Present

Mule deer populations have been declining over the past couple of decades in many parts of the western United States. Often times, predators are blamed for the decreases in deer populations. Because of this, wildlife managers implement programs focused on reducing the number of predators on the landscape in an attempt to increase deer populations. However, predator removal programs have had mixed results, thus further investigation is needed to determine if coyote removals by the public through a bounty program have a positive effect on mule deer populations. My study investigated whether coyote removals through the bounty program in Utah …

Addressing Anxiety And Depression In The Allergy Clinic Through Motivational Interviewing, Brief Cognitive Behavioral Therapy, And Curious Questions, Marylee Verdi, Dominic Candido, Juliette Madan, Jonathan A Bernstein, Don Bukstein, Aikaterini Anagnostou, Matthew Greenhawt, S Shahzad Mustafa, Julie Wang, Anna Nowak-Wegrzyn, Elissa M Abrams, John Oppenheimer, Alexandra E Conway, Andrew A White, Taylor A Doherty, Richard P Morse, Marcus Shaker

Faculty, Staff and Students Publications

Allergic diseases, particularly food allergy, can be associated with significant psychosocial impairment. Allergist-immunologists can provide evidence-based information to correct misperceptions and misunderstandings regarding food allergy that may perpetuate cycles of fear and anxiety. Whereas motivational interviewing can be an empathetic approach to empower patients to actualize health goals, cognitive behavioral therapy (CBT) aims to provide disease-state insight to facilitate an understanding of risk that can transform health beliefs and behaviors. Brief CBT is a clinical approach that can help address ineffective management paradigms through conversations that begin with curious questions. In this review, we discuss evidence supporting implementation of an …

How Does Body Mass Index Affect Breast Cancer Risk In Postmenopausal Women With And Without Cardiovascular Disease?

Saudi Medical Journal

No abstract provided.

Gastrointestinal Infection Before Immune Checkpoint Inhibition Hinders Treatment Efficacy And Increases The Risk Of Colitis, Malek Shatila, Kian Abdul-Baki, Andres Urias Rivera, Kei Takigawa, Irene Jeong-Ah Lee, Andrew Sullivan, Tanvi Gupta, Linfeng Lu, Raakhi Menon, Ayesha Khan, Hamza Salim, Elliot Baerman, Carolina Colli Cruz, Cristina Natha, Varun Vemulapalli, Garrett Coleman, Krishnavathana Varatharajalu, Christopher Fan, Pablo Okhuysen, Anthony J Olszanski, Yan Zhou, Hao Chi Zhang, Mehnaz Shafi, Yinghong Wang

Faculty, Staff and Students Publications

Background: Gastrointestinal (GI) infections, which often result in or stem from intestinal dysbiosis, can affect the efficacy of immune checkpoint inhibitors (ICIs) and increase the risk of adverse effects, such as colitis. In this study, we explored the impact of GI infections before initiation of ICI therapy on the incidence and severity of immune-mediated colitis (IMC) and survival.

Methods: A single-center, retrospective review including all patients who received ICIs from January 2010 to February 2024 and subsequently developed IMC. Patients were screened for IMC and prior GI infections based on symptoms and stool tests. Patients' demographic, IMC, and GI infection-related …

Blood Biomarkers Of Alzheimer's Disease In Australians Habitually Consuming Various Plant-Based Diets, Shaun Eslick, Grace Austin, Jessica J.A. Ferguson, Manohar L. Garg, Christopher Oldmeadow, Ralph N. Martins

Research outputs 2022 to 2026

Background: Evidence suggests that plant-based diets (PBDs) may be protective against neurodegenerative diseases such as Alzheimer's disease (AD). Objective: This study examined associations between blood-based AD biomarkers in individuals 30–75 years without current or diagnosed cardiovascular disease following different PBDs versus regular meat-eating diets (RMEs). Methods: This secondary analysis of the Plant-based Diets study measured Aβ1–42/Aβ1–40, p-tau181, NFL, and GFAP in 237 plasma samples using SIMOA from individuals following vegan, pesco-vegetarian (PVs), lacto-ovo vegetarian (LOVs), semi-vegetarian (SVs), or RME diets. Multivariable regression adjusted for age and sex. Results: Following adjustments for age and sex, plasma Aβ1–42/Aβ1–40ratio was significantly higher in …

Supplementing Tannins To Increase Performance And Reduce Methane Emissions In Cows Grazing On Western Grasslands, Horacio Pedro Blanchard

All Graduate Theses and Dissertations, Fall 2023 to Present

Cattle grazing on U.S. rangelands often rely on a limited diet made up mostly of grasses. As the seasons change from spring to fall, the nutritional quality of these grasses declines, leading to less efficient digestion and higher production of methane—a potent greenhouse gas. In addition, most grass-based pastures lack beneficial plant compounds, such as tannins.

This study explored whether adding natural tannins—specifically, condensed and hydrolyzable tannins from quebracho and chestnut trees—to the diet of grazing cattle could improve how the use efficiency of nutrients and reducing methane emissions from cattle. Over two years, 24 cow-calf pairs grazed in small …

Ctso Implementation In Secondary Education: Insights Into Teacher Motivation, Barriers And Training Needs, Ariane Crystal

All Graduate Theses and Dissertations, Fall 2023 to Present

This study explores the role of Career and Technical Student Organizations (CTSOs) in enhancing the educational experiences of secondary Career and Technical Education (CTE) teachers in Utah. By surveying CTE educators, the research identifies key factors that motivate teachers to implement CTSOs, as well as barriers they face in doing so. The findings indicate that a significant majority of teachers recognize the value of CTSOs for fostering student engagement and career readiness. Key motivators include support from school administration and access to professional development, while challenges such as time constraints and resource limitations hinder participation. The study highlights the importance …

The Socioecology Of Indigenous Archaeological Maize In The Uinta Basin, Utah, Sara Saouma

All Graduate Theses and Dissertations, Fall 2023 to Present

This thesis investigates the phenotypic variability of maize (Zea mays spp.) from archaeological sites located in the Uinta Basin, Utah. Maize was first introduced to the American Southwest around 5,000 years ago following its migration via trade routes from its native region of southern Mexico (Vint 2017). The adaptation of maize to the arid and temperate conditions of the American Southwest and Mexico triggered significant phenotypic change resulting from human and environmental selection pressures. This thesis focuses on the analysis of uncharred maize cobs from seven archaeological sites in the Uinta Basin. The analysis includes 70 corn cobs—most …

Watermelon Production In Utah: Exploring Biostimulants To Reduce Water And Fertilizer Use, Evan A. Christensen

All Graduate Theses and Dissertations, Fall 2023 to Present

The impacts of climate change and drought threaten water supplies that are important for watermelon production. Additionally, rising fertilizer costs and off-site effects from improper fertilizer applications cause concerns for the sustainability of watermelon production. Biostimulant products have shown promise in helping plants maintain production under reduced irrigation conditions and may offset fertilizer addition. Biostimulants are any microorganism or substance that is applied to a plant with the goal to increase nutrition efficiency, crop quality traits, or tolerance to environmental stresses. Most of the production in the U.S. uses seedless watermelon which are typically grown in greenhouses and transplanted due …

Remote Detection Of Pest Damage And Tree Health In Tart Cherry, Christina Klara Lilligren

All Graduate Theses and Dissertations, Fall 2023 to Present

With the increasing affordability of technology, using technological advancements to assess tree health might soon become a possibility in low input crops such as tart cherry. We evaluated the ability of drone-mounted multispectral cameras, ceptometry

(canopy density), and soil conductivity meters (soil texture) to predict pest occurrence and remotely detect tree health. Pest scouting data were compared to the different technological datasets to identify the possibility of use for pest detection. While drone-mounted multispectral cameras were able to identify chlorotic trees, powdery mildew was not reliably detectable under a management threshold with current multispectral camera technology. Trees with low canopy …

Endogenous Analgesia, Assessed Via Conditioned Pain Modulation, Is Not Different In People With Hip Osteoarthritis Compared To Controls: A Cross-Sectional Study, Myles C. Murphy, Molly Coventry, Ebonie K. Rio, Paola T. Chivers, Benedict Wand, Gordon Waddington, Andrea B. Mosler

Research outputs 2022 to 2026

Background: In people with knee osteoarthritis, measures of pain sensitivity have been demonstrated to relate to both pain severity and treatment outcomes, dependent on the type of pain sensitivity being tested. Objective: Quantify if differences in the pressure pain thresholds (PPT) or conditioned pain modulation (CPM) effect exist between people with hip osteoarthritis and age-matched controls without hip osteoarthritis. Methods: We performed a cross-sectional study across two geographic locations. PPTs at a local (hip) and remote (elbow) site were collected via a manual algometer. CPM was quantified using PPTs immediately prior to, and during ice water immersion of the hand …

Exercise Perceptions In People With Metabolic Dysfunction-Associated Steatotic Liver Disease: Insights From A Qualitative Study, Kedar Deshpande, John Olynyk, Oyekoya Ayonrinde, Kazunori Nosaka

Research outputs 2022 to 2026

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic liver condition associated with lifestyle and metabolic risk factors. While exercise is a beneficial treatment strategy, many patients struggle to implement and perform exercise regularly. It is important for practitioners to know about patient awareness, attitudes, and preferences regarding exercise in the con-text of MASLD. In this study, we examined exercise knowledge, attitudes, and exercise preferences among patients with MASLD to improve their exercise behavior changes. Methods: We conducted a questionnaire and semi-structured inter-view study in adults with MASLD to assess their disease awareness, perspectives on exercise and exercise preferences. …

The Role Of Diet In Moderating The Relationship Between Symptoms Of Depression And Brain Amyloid Load, Hilal Salim Said J. Al Shamsi, Samantha L. Gardener, Stephanie R. Rainey-Smith, Hamid R. Sohrabi, Kevin C.M. Taddei, Colin L. Masters, Vincent M. Doré, Christopher L. Rowe, W. M.A.D.Binosha Fernando, Ralph N. Martins

Research outputs 2022 to 2026

Background: Healthy lifestyle factors, including diet, may affect brain amyloid beta (Aβ) load. This study examines dietary patterns as moderators of the relationships among symptoms of depression, anxiety, and brain Aβ load. Method: A cross-sectional study of cognitively unimpaired older adults (n = 524) from the Australian Imaging, Biomarkers, and Lifestyle study assessed dietary patterns, depressive and anxiety symptoms, and brain Aβ load. Moderation and simple slope analyses were conducted. Results: The Dietary Approaches to Stop Hypertension (DASH) diet moderated the relationship between depressive and anxiety symptoms and brain Aβ load. Higher symptoms were associated with greater Aβ load in …

Understanding The Role Of Sports Injury Management By Australian Osteopaths: A Cross Sectional Survey Of 992 Practitioners, Brett Vaughan, Jon Adams, Wenbo Peng, Lauren V. Fortington, Michael Fleischmann, Kylie Fitzgerald, Amie Steel, David Sibritt

Research outputs 2022 to 2026

Sport-related injuries are common presentations to primary care and hospital settings. Australian osteopaths practice mainly in private clinical settings in which the frequency of sport-related injury presentations, and how these injuries are managed, is unknown. The objective of the study was to describe the demographic, practice, and clinical management characteristics of Australian osteopaths who report often treating sport-related injuries. The study is a secondary analysis of data derived from the Australian osteopathy practice-based research network. Respondents indicated the frequency treating sports-related injuries in addition to other demographic, practice, and patient management characteristics. Backward logistic regression identified significant characteristics associated with …

Effect Of Aerobic Or Resistance Exercise, Or Both On Insulin Secretion, Ciliary Neurotrophic Factor, And Insulin-Like Growth Factor-1 In Dieting Older Adults With Obesity, Georgia Colleluori, Viola Viola, Siresha Bathina, Reina Armamento-Villareal, Clifford Qualls, Antonio Giordano, Dennis T Villareal

Faculty, Staff and Students Publications

Background and aims: Obesity exacerbates age-related changes in metabolic and physical function. The effect of distinct exercise modalities combined with diet-induced weight loss on insulin secretion in older adults with obesity and frailty is unknown, and the potential mediators of the metabolic and functional improvements induced by lifestyle therapy still need to be identified. We aimed to assess the effects of various exercise therapies coupled with diet-induced weight loss on insulin secretion and sensitivity and on the levels of circulating Ciliary Neurotrophic Factor (CNTF), its receptor (CNTFRα), and Insulin-like Growth Factor-1 (IGF-1) in older adults with both obesity and frailty. …

Prevalence Of Fibrosis In Hepatic Explants And Biopsies From Individuals With Urea Cycle Disorders, Saima Ali, Aisha Nisar, Anqing Zhang, Sandesh Nagamani, Nathalie M Aceves-Ewing, Brandy Rawls, Thu Quan, Greg Enns, John Goss, Daniel H Leung, Benjamin L Shneider, Shilpa Jain, Florette K Hazard, Deborah Schady, Lindsay C Burrage

Faculty, Staff and Students Publications

Background: Various forms of liver disease have been increasingly reported in individuals with urea cycle disorders (UCDs). In this study, we performed the first systematic and standardized histopathological assessment of the prevalence of fibrosis and steatosis in a large sample of hepatic explants and biopsies from individuals with UCDs at two liver transplantation centers.

Methods: Sixty-seven hepatic tissue samples from 66 individuals with UCDs were staged by two pathologists for hepatic fibrosis and steatosis using standard scoring systems at two large liver transplantation centers in the United States. Histopathological findings were correlated with clinical parameters, including UCD type, laboratory parameters, …

Rural Peer Helpers Speak: How One Program Makes A Difference, Misty S. Whisenhunt

College of Education

The problem this mixed-methods convergent research study aimed to explore was the increasing incidence of rural high school students performing poorly academically, socially, and emotionally. This mixed-methods convergent research study aimed to examine one peer helper program as perceived by rural high school peer helpers. This research study aimed to answer the following research questions: (1) How do rural high school peer helpers perceive their experience as a peer helper? (2) What are the key elements of Thriveway’s Peer Helpers PLUS Program as perceived by rural high school peer helpers? (3) How effective is Thriveway’s Peer Helpers PLUS Program’s training …

Semaphorin 3e-Plexin-D1 Pathway Downstream Of The Luteinizing Hormone Surge Regulates Ovulation, Granulosa Cell Luteinization, And Ovarian Angiogenesis In Mice, Hanxue Zhang, Jimmy Dhillon, Paul D Soloway, Bo Shui, Seoyeon Lee, Jennifer K Grenier, Paul R Munn, M Cecilia Ljungberg, Rebecca B Williams, Rainer B Lanz, Yu-Hsiang Liao, Yi A Ren

Faculty, Staff and Students Publications

Ovulation is induced by the luteinizing hormone (LH) surge and accompanied by granulosa cell luteinization and ovarian angiogenesis. Semaphorin 3E (Sema3E)-Plexin-D1 pathway regulates angiogenesis in other tissues, but its role in the ovary is unknown. Evidence indicates that Sema3E-Plexin-D1 pathway plays an important role in the mouse ovary. The expression of Sema3E and its receptor, Plexin-D1, is dynamically regulated in the mouse ovary downstream of the LH surge. This regulation requires the modulation of chromatin accessibility by CCAAT/enhancer-binding proteins α and β. Intraovarian injection of recombinant Sema3E results in reduced ovulation, impaired corpus luteum formation, and aberrant ovarian angiogenesis. These …

Rest-Activity Rhythm Phenotypes In Adults With Epilepsy And Intellectual Disability, Nandani Adhyapak, Grace E Cardenas, Mark A Abboud, Vaishnav Krishnan

Faculty, Staff and Students Publications

Objective: Rest-activity rhythms (RARs) are perturbed in many forms of neuropsychiatric illness. In this study, we applied wrist actigraphy to describe RAR perturbations in intellectually disabled adults with epilepsy ("E + ID"), using a cross-sectional case-control design. We examined whether RAR phenotypes correlated with epilepsy severity, deficits in adaptive function, and/or comorbid psychopathology.

Methods: Caregivers of E + ID subjects provided informed consent during routine ambulatory clinic visits and were asked to complete standardized surveys of overall epilepsy severity (GASE, Global Assessment of Severity of Epilepsy), adaptive function (ABAS-3, Adaptive Behavior Assessment System-3) and psychopathology (ABCL, Adult Behavior Checklist). Caregivers …

The Psychiatric Genomics Consortium: Discoveries And Directions, Arpana Agrawal, Cynthia M Bulik, Dawit Shawel Abebe, Ole A Andreassen, Elizabeth G Atkinson, Karmel W Choi, Aiden Corvin, Helena L Davies, Lea K Davis, Anna R Docherty, Howard J Edenberg, Barbara Franke, Joel Gelernter, Paola Giusti-Rodríguez, John M Hettema, Jens Hjerling-Leffler, Hailiang Huang, Emma C Johnson, Cathryn M Lewis, Yi Lu, Mary-Ellen Lynall, Joanna Martin, Andrew M Mcintosh, Janitza L Montalvo-Ortiz, Niamh Mullins, Caroline M Nievergelt, Kevin S O'Connell, Michael C O'Donovan, Adeniran Okewole, Roseann E Peterson, Danielle Posthuma, Jonathan Sebat, Jordan W Smoller, Reeteka Sud, Biju Viswanath, James T R Walters, Hyejung Won, Naomi R Wray, Patrick F Sullivan, Coordinating Committee Of The Psychiatric Genomics Consortium

Faculty, Staff and Students Publications

The Psychiatric Genomics Consortium (PGC) has fueled discoveries of common and rare genetic variation contributing to liability to many psychiatric and neurodevelopmental conditions. This narrative review reflects on major findings from the past half decade of research by this international group of investigators in five priority areas: discovery of common variants using GWAS; rare variation and its interplay with polygenic risk; leveraging genetics to go beyond diagnostic boundaries; ascribing functional attributes to genomic discoveries; and developing and implementing processes for data sharing, outreach to various communities, and training. The insights gained in these domains frame the agenda for the next …

Leviathan, Thomas Hobbes

Hannah Arendt Marginalia - All

London, Dent [n.d.]

Call #: JC153 .H656

Contains markings

PDF Information: 20 pages – 8 MB

Safety Handbook - Faculty And Staff

University press releases and calendars

No abstract provided.

Icipe Spotlight Magazine 2025, International Centre Of Insect Physiology And Ecology (Icipe)

icipe Newsletters

Join us through a journey of a tapestry of voices, landscapes and possibilities. Get a copy of our inaugural edition of the icipe Spotlight magazine, a publication that is especially close to our hearts. The magazine illuminates our scientific breakthroughs and the lives they touch. While we celebrate our contribution to the global knowledge hub, our deepest fulfillment is in witnessing how the Centre’s knowledge and innovations transform lives and foster resilience.

Effect Of Moringa Oil And Flaxseed Oil On Lipid Profile Of Male Rats Exposed To Carbendazim, Muhammad Hashim, Isam M. Abu Zeid, Atef M. Al-Attar

The Journal of King Abdulaziz University: Science

Carbendazim (CBZ), a commonly used fungicide, has been linked to adverse effects on the lipid profile. This study investigated whether Moringa and Flaxseed oils could mitigate CBZ-induced toxicity in male rats. Sixty male rats were divided into six groups: control, CBZ (200 mg/kg) treated, CBZ + Moringa Oil, CBZ + Flaxseed Oil, Moringa treated, and Flaxseed Oil treated. The oils were administered at 800 mg/kg for six weeks. Lipid parameters, including total cholesterol (TC), triacylglycerols (TG), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and high-density lipoprotein (HDL), were analyzed. CBZ elevated TC, TG, LDL, and VLDL levels, while reducing HDL. Moringa …

Determinants Of School Health Unit Program Implementation In Junior High Schools Of Boyolali District, Indonesia, Ayu Khoirotul Umaroh, Noor Alis Setiyadi, Kusuma Estu Werdani, Tanjung Anitasari Indah Kusumaningrum, Purwo Setiyo Nugroho

Kesmas

Adolescent health problems such as stunting, attempted suicide, and tobacco use in Indonesia require attention. To address these challenges, the School Health Unit Program, a school-based health initiative, aims to improve student health and academic achievement. This study examined the relationship between human resources, teachers’ knowledge, facilities and infrastructure, financial resources, and the planning process for implementing the School Health Unit Program in junior high schools in Boyolali District, Indonesia. A cross-sectional design was utilized, involving 50 junior high school teachers responsible for the School Health Unit as respondents, with data collected through structured questionnaires. Multivariate logistic regression analysis revealed …

Unveiling The Marketing Tactics Of Indonesian Fundamentalist Group: A Delphi Method Analysis, Arindra Khrisna Karamoy, Adrianus Meliala

Journal of Strategic and Global Studies

This study investigated whether Indonesian fundamentalist group utilizes marketing principles for recruitment. The research employed a Delphi method, gathering expert consensus from marketing, communication, and visual communication fields to assess the group's use of marketing strategies in attracting sympathizers and disseminating their ideology. The first round demonstrated complete agreement on the use of marketing principles. The second round revealed some disagreement regarding the classification of mosques as distribution channels, suggesting a nuanced application focusing more on promotion than traditional marketing models. The findings highlight sophisticated marketing techniques used by this group, emphasizing the need for further investigation into how such …