Digital Commons Network^™

Innovative Approaches In Precision Radiation Oncology: Advanced Imaging Technologies And Challenges Which Shape The Future Of Radiation Therapy, Yue Yan, Daniel A Alexander, Bryan P Bednarz, Lawrence F Bronk, Huixiao Chen, David J Gladstone, Bin Han, Christopher M Iannuzzi, Yuting Li, Ngoc Nguyen, Natasha Mulenga, Natalie N Viscariello, Yuenan Wang, Joseph Weygand, Yana Zlateva, Fada Guan

Faculty, Staff and Student Publications

Radiation oncology is undergoing a transformative shift toward precision medicine through unprecedented advances in imaging technologies that enable increasingly personalized and adaptive cancer treatment. This comprehensive review synthesizes the underlying physical principles, current clinical applications, technical challenges, and quality assurance requirements across the complete spectrum of emerging imaging-guided radiation therapy approaches. We examine magnetic resonance-guided radiotherapy systems that enable daily soft-tissue visualization and online plan adaptation, positron emission tomography-guided platforms that allow real-time tracking of metabolically active tumor regions, advanced cone beam computed tomography systems supporting rapid adaptive workflows through artificial intelligence-enhanced image generation, and novel applications including Cherenkov radiation …

Correction: Innovative Approaches In Precision Radiation Oncology: Advanced Imaging Technologies And Challenges Which Shape The Future Of Radiation Therapy, Yue Yan, Daniel A Alexander, Bryan P Bednarz, Lawrence F Bronk, Huixiao Chen, David J Gladstone, Bin Han, Christopher M Iannuzzi, Yuting Li, Ngoc Nguyen, Natasha Mulenga, Natalie N Viscariello, Yuenan Wang, Joseph Weygand, Yana Zlateva, Fada Guan

Faculty, Staff and Student Publications

No abstract provided.

Fatty Pancreas On Eus: Risk Factors, Correlation With Ct/Mri, And Implications For Pancreatic Cancer Screening, Ramez M Ibrahim, Shantanu Solanki, Wei Qiao, Hyunsoo Hwang, Ben S Singh, Irina M Cazacu, Adrian Saftoiu, Matthew H G Katz, Michael P Kim, Florencia Mcallister, Manoop S Bhutani

Faculty, Staff and Student Publications

Background and objectives: Fatty pancreas (FP), traditionally perceived as a benign finding, has been undergoing scrutiny lately due to growing evidence linking it to various disease states, including increased risk for pancreatic cancer (PC).

Methods: A retrospective study of patients who underwent EUS at a single institution from August 2007 to October 2023, conducted by one endosonographer with more than 25 years of experience. Focusing on individuals identified with FP during EUS, we compared these findings with corresponding findings on computed tomography/magnetic resonance imaging (CT/MRI) conducted within 3 months or 1 year prior to or following EUS.

Results: Ninety-one patients …

Inducing Hypertension In Myh11r247c/R247c Mice Triggers Aortic Dissections With Increased Focal Adhesion Kinase Signaling, Callie S Kwartler, Shanzhi Wang, Zhen Zhou, Pujun Guan, Yang Yu, Xue-Yan Duan, Theodore Zhang, Jiyuan Chen, Elaine C Davis, Dianna M Milewicz

Faculty, Staff and Student Publications

Objective: We sought to determine if hypertension in combination with a "variant of uncertain significance" that disrupts protein function, MYH11 p.Arg247Cys, would induce aortic dissections in a mouse model.

Approach and results: Administration of L-NAME via drinking water and a high salt diet increased blood pressure in WT and Myh11R247C/R247C mice and triggered type A dissections with cardiac tamponade in 20% of the Myh11R247C/R247C mice. Myh11R247C/R247C aortas have aberrant smooth muscle contractile unit-elastin connections by transmission electron microscopy, along with increased focal adhesion signaling at baseline, which further increases with hypertension.

Conclusion: Gene-environment interactions trigger aortic dissections in Myh11R247C/R247C mice.

New Insights Into The Mechanisms Of Electroconvulsive Therapy In Treatment-Resistant Depression, Ana C Ruiz, Abdul Haseeb, William Baumgartner, Edison Leung, Giselli Scaini, Joao Quevedo

Faculty, Staff and Student Publications

Electroconvulsive therapy (ECT) remains one of the most effective interventions for treatment-resistant depression (TRD), particularly in cases involving severe symptomatology, suicidality, or psychotic features. Despite advancements aimed at enhancing the safety and cognitive tolerability of ECT, concerns about cognitive side effects continue to limit its broader acceptance. A deeper understanding of the mechanisms underlying ECT is therefore critical for refining its use and maximizing clinical outcomes. Through a narrative review of recent literature, this paper synthesizes current evidence comparing the efficacy of ECT, ketamine, and repetitive transcranial magnetic stimulation (rTMS) in the treatment of TRD. Then, the review delves into …

Correspondence To Letter To The Editor On “Genomic Biomarkers To Predict Response To Atezolizumab Plus Bevacizumab Immunotherapy In Hepatocellular Carcinoma: Insights From The Imbrave150 Trial”, Sung Hwan Lee, Sun Young Yim, Ji Hoon Kim, Sunyoung S Lee, Ahmed O Kaseb, Peng Wei, Ju-Seog Lee

Faculty, Staff and Student Publications

No abstract provided.

The Tripod-Llm Reporting Guideline For Studies Using Large Language Models, Jack Gallifant, Majid Afshar, Saleem Ameen, Yindalon Aphinyanaphongs, Shan Chen, Giovanni Cacciamani, Dina Demner-Fushman, Dmitriy Dligach, Roxana Daneshjou, Chrystinne Fernandes, Lasse Hyldig Hansen, Adam Landman, Lisa Lehmann, Liam G Mccoy, Timothy Miller, Amy Moreno, Nikolaj Munch, David Restrepo, Guergana Savova, Renato Umeton, Judy Wawira Gichoya, Gary S Collins, Karel G M Moons, Leo A Celi, Danielle S Bitterman

Faculty, Staff and Student Publications

Large language models (LLMs) are rapidly being adopted in healthcare, necessitating standardized reporting guidelines. We present transparent reporting of a multivariable model for individual prognosis or diagnosis (TRIPOD)-LLM, an extension of the TRIPOD + artificial intelligence statement, addressing the unique challenges of LLMs in biomedical applications. TRIPOD-LLM provides a comprehensive checklist of 19 main items and 50 subitems, covering key aspects from title to discussion. The guidelines introduce a modular format accommodating various LLM research designs and tasks, with 14 main items and 32 subitems applicable across all categories. Developed through an expedited Delphi process and expert consensus, TRIPOD-LLM emphasizes …

The Impact Of A Small-Group Mammography Video Discussion On Promoting Screening Uptake Among Nonadherent Chinese American Immigrant Women: A Randomized Controlled Trial, Naomi Q P Tan, Grace X Ma, Annette E Maxwell, Roger L Brown, Kathy Zhou, Alice Loh, Lucy Young, Robert J Volk, Qian Lu, Judy Huei-Yu Wang

Faculty, Staff and Student Publications

Background: The objective of this study was to evaluate the efficacy of an in-person, small-group mammography video discussion (SMVD) intervention on mammography uptake among nonadherent Chinese American immigrant women.

Methods: Women (N = 956) were randomized into either an SMVD group, where Chinese-speaking community health workers (CHWs) used an effective, culturally appropriate video to discuss mammography, or a video-only group, which viewed the cultural video sent by mail. Outcomes were mammography uptake at 6 months and 21 months postintervention.

Results: Women in both groups increased mammography uptake, and an outcome analysis revealed no group differences (adjusted odds ratio [AOR], 1.18; …

Stat3 Inhibition In Combination With Cd47 Blockade Inhibits Osteosarcoma Lung Metastasis, Pradeep Shrestha, Rejeena Shrestha, You Zhou, Rafal Zielinski, Waldemar Priebe, Eugenie S Kleinerman

Faculty, Staff and Student Publications

Background: New therapies are urgently needed for patients with osteosarcoma (OS). STAT3 and CD47 are potential therapeutic target in OS. Here we investigated the therapeutic activity of the orally bioavailable STAT3 inhibitor, WP1066, and anti-CD47 antibody using OS mouse models.

Methods: Cytotoxic effect of WP1066 against OS cell lines and its immunomodulatory effects were evaluated in vitro. Experimental metastasis and orthotopic syngeneic mouse models were used to investigate the therapeutic efficacy of WP1066 and anti-CD47 antibody. Further flow cytometric analysis was performed.

Results: STAT3 was constitutively activated in multiple human and mouse OS cell lines. WP1066 suppressed STAT3 activation …

Evaluation Of Quantum Contouring Algorithms For Treatment Planning On Mr Abdominal Images, Rachel Glenn, Tucker Netherton, Adrian Celaya, Mohamed Eltaher, Beatrice Riviere, Eugene J Koay, David Fuentes

Faculty, Staff and Student Publications

Introduction: Quantum computing is increasingly being investigated for integration into medical radiology and healthcare applications worldwide. Given its potential to enhance clinical care and medical research, there is growing interest in evaluating its practical applications in clinical workflows.

Methods: We developed an evaluation of quantum computing-based auto-contouring methods to introduce medical physicists to this emerging technology. We implemented existing quantum algorithms as prototypes tailored for specific quantum hardware, focusing on their application to auto-contouring in medical imaging. The evaluation was performed using a medical resonance imaging (MRI) abdominal dataset, comprising 102 patient scans.

Results: The quantum algorithms were applied to …

Novel Use And Value Of Contrast-Enhanced Susceptibility-Weighted Imaging Morphologic And Radiomic Features In Predicting Extremity Soft Tissue Undifferentiated Pleomorphic Sarcoma Treatment Response, Raul F Valenzuela, Elvis De Jesus Duran Sierra, Mathew A Canjirathinkal, Behrang Amini, Ken-Pin Hwang, Jingfei Ma, Keila E Torres, R Jason Stafford, Wei-Lien Wang, Robert S Benjamin, Andrew J Bishop, John E Madewell, William A Murphy, Colleen M Costelloe

Faculty, Staff and Student Publications

Purpose: Undifferentiated pleomorphic sarcomas (UPSs) demonstrate therapy-induced hemosiderin deposition, granulation tissue formation, fibrosis, and calcification. We aimed to determine the treatment-assessment value of morphologic tumoral hemorrhage patterns and first- and high-order radiomic features extracted from contrast-enhanced susceptibility-weighted imaging (CE-SWI).

Materials and methods: This retrospective institutional review board-authorized study included 33 patients with extremity UPS with magnetic resonance imaging and resection performed from February 2021 to May 2023. Volumetric tumor segmentation was obtained at baseline, postsystemic chemotherapy (PC), and postradiation therapy (PRT). The pathology-assessed treatment effect (PATE) in surgical specimens separated patients into responders (R; ≥90%, n = 16), partial responders …

Building Boundary-Crossers In Clinical-Translational Research: An Exploratory Study Of A Novel Communication Intervention, Carrie Cameron, Irene Rull-Garcia, Laura G Meyer, Jose-Armando Fernandez-Guerrero, Erin K Dahlstrom, Christine Bell, Christine Pribbenow

Faculty, Staff and Student Publications

INTRODUCTION: Integrating scientific research across multiple disciplines to advance breakthroughs is at the heart of clinical-translational science (CTS); among competencies that have been identified as essential for progress, skillful communication is critical. Few tools are available to address the social dynamics of the multidimensional diversity characteristics of CTS. We created the "Building a Diverse Biomedical Workforce Through Communication Across Difference (CAD)" workshop intervention. Based on principles of intercultural communication, CAD taught novel situationally-based communication skills to dyads of near-peer mentors and their undergraduate mentees. This study reports on the effectiveness of the operative mechanisms employed in CAD workshops for helping …

Cord Blood-Derived Ink T Cells As A Platform For Allogeneic Car T Cell Therapy, Maison Grefe, Abel Trujillo-Ocampo, Jelita Clinton, Hong He, Ling Yu, Dan Li, Qing Ma, Elizabeth J Shpall, Jeffrey J Molldrem, Jin S Im

Faculty, Staff and Student Publications

CD1d-restricted invariant Natural Killer (iNK) T cells are a suitable candidate for allogeneic Chimeric Antigen Receptor (CAR) T cell therapy as they do not cause graft-versus-host disease (GvHD) due to the monomorphic nature of CD1d proteins. However, the phenotypic and functional heterogeneity of iNK T cells from adult donors (AD) may lead to the inconstant CAR-iNK T cell products. Cord blood-derived (CB) iNK T cells, in contrast, exhibit inter-donor homogeneity in phenotype including uniform CD4 expression and are enriched in memory iNK T cell populations. Thus, we evaluated the preclinical therapeutic potential of iNK T cells derived from cord blood …

Mental Silence For Emotional Intelligence Development, Mina N. Nandwani

Theses and Dissertations

While emotional intelligence is considered key for effective leadership, and perhaps the most vital competency for current and emerging leaders to cultivate, there appears to be uncertainty on how to develop it. This study examined how the practice of Sahaja Yoga Meditation (SYM) influences the development of emotional intelligence and contributes to the advancement of global leadership capacities, addressing a gap in the current literature. The conceptual frameworks of SYM, Daniel Goleman’s Emotional Intelligence Model, and the literature on global leadership, particularly Jeffrey Sachs’ Ages of Globalization, guided the research question. By implementing a qualitative phenomenological research approach, ten long-time …

Benefits And Challenges With The Modular Model Of Teacher Certification In Australia: Listening To Teachers’ Voices, Bernard Brown, Rohan Nethsinghe

Australian Journal of Teacher Education

This paper examines teachers’ views about the Highly Accomplished and Lead Teacher (HALT) Certification 2.0 Modular Model (CMM 2.0). The research reveals teachers’ voices and agency in relation to HALT certification. Participants in this study included HALT certified teachers, current HALT participants, and prospective participants. The semi-structured interviews conducted provide insights into the benefits and challenges associated with the CMM 2.0. Thematic coding and systematic analysis were applied to the data to arrive at the key findings. The research revealed that teachers believed that the modular approach was advantageous as it was flexible and provided professional recognition and development. Issues …

Challenging Assumptions: Ai And Teacher Assessment Identity Formation, Nadia Ollington

Australian Journal of Teacher Education

This article explores the ways in which teacher educators can strengthen the developing teacher assessment identity of preservice teachers who are at the precipice of Industry 4.0, where work with Artificial Intelligence (AI) and assessment will require flexible thinking. This reflective case study narrative outlines a teacher educator’s experiences in a novel assessment task using Generative AI for technology enhanced learning in an Australian postgraduate teaching program. In the task, those who held positive beliefs and emotions about AI were more likely to engage in flexible thinking skills than those who were more critical of the AI. To ensure that …

Changes In Mentor Teacher Participation In Postgraduate Secondary Initial Teacher Education: Climatic Conditions Preceding Workforce Reform., Alison L. Hilton, Chad Morrison, Felicity I. Mclure, Kathryn G. Dehle, Sandi Fielder

Australian Journal of Teacher Education

Professional Experience placements provide invaluable opportunities for pre-service teachers to connect their expanding knowledge to teaching practice. When done well, these experiences are underpinned by purposeful and continuous guidance from experienced mentor teachers. Significantly, the participation and engagement of Australian mentor teachers in this process is voluntary in nature, meaning the system relies on teachers ‘opting-in’ to mentoring. This research examines mentor teacher participation within Secondary-level initial teacher education courses and highlights issues relating to overall mentor teacher (and host school) engagement. Analysis of placement data over a five-year period to 2021 illustrates a significant change in participation with a …

Fostering Learner Autonomy In Efl Setting Through Multiliteracy Pedagogy: A Case In Tertiary Education, Desi Surlitasari Dewi, Rudi Hartono, Sri Wahyuni, Sri Lestari

Australian Journal of Teacher Education

The intersection of learner autonomy and multiliteracy pedagogy in EFL settings remains underexplored. To address this gap, this study investigates how multiliteracy pedagogy fosters learner autonomy in the EFL context. The study involved 24 university students majoring in English, for whom English was primarily a third language. The participants attended an intermediate speaking course, a compulsory class in their curriculum. A learner autonomy questionnaire was administered to measure autonomy in the EFL speaking context before and after the implementation. Additionally, semi-structured interviews and classroom observations enriched the data. The findings indicate a significant improvement in learner autonomy following the implementation …

Raising Information Literacy Of Biology Pre-Service Teachers: Study On Three Problem Solving Methods, Muhammad Saefi, Hadi Suwono, Rifka Fachrunnisa, Widi Cahya Adi, Herawati Susilo, Ahmad Kamal Sudrajat

Australian Journal of Teacher Education

Integrating information literacy teaching methods with subject-content curricula to develop prospective biology teacher students' abilities is still problematic. This quasi-experimental research, with a nonrandomized pretest-posttest control group design, intends to compare the influences of challenge-based learning (CBL), problem-based learning (PBL), and problem-solving through classroom discussion (PCD) – as the control- in improving information literacy. This study involved 183 students from three classes of freshmen and three sophomores in the biology education program. The results showed that CBL significantly improved students' information literacy compared to PBL and PCD across five indicators: 1) identifying the required information, 2) attaining the required information …

A Decolonial And Liberation Lens To Social Justice Research: Upholding Promises For Diverse, Inclusive, And Equitable Psychological Science, Luz M. Garcini, Aldo Barrita, German Cadenas, Melanie M. Domenech Rodriguez, Thania Galvan, Alfonso Mercado, Oswaldo Moreno, Manuel Paris, Oscar F. Rojas Perez, Michelle Silva, Amanda Venta

Psychological Science Faculty Publications

In the face of harmful disparities and inequities, it is crucial for researchers to critically reflect on methodologies and research practices that can dismantle systems of oppression, accommodate pluralistic realities, and facilitate opportunities for all communities to thrive. Historically, knowledge production for the sciences has followed a colonial and colonizing approach that continues to silence and decontextualize the lived experiences of people of color. This article acknowledges the harm to people of color communities in the name of research and draws from decolonial and liberation frameworks to advance research practices and psychological science toward equity and social justice. In this …

Petrophysical And Petrographic Characterisation Of The Reservoirs In Niger Delta For Carbon Capture And Storage, Itai Mutadza, Sunday Ikiensikimama, Ogbonna F. Joel

All Rsif Scholars' Publications

The unprecedented levels of carbon dioxide in the atmosphere are linked to the rising average temperatures that the world is experiencing. Carbon sequestration in geological formations is one of the key strategies to combat climate change. However, it is essential to characterise these geological formations to assess the potential success of environmentally friendly carbon sequestration. Controlling carbon sequestration and its migration within porous sandstones is largely dependent on the textural and geometrical characteristics of the pore networks, including tortuosity, connectivity, pore size distribution, and pore shape. Microstructural analysis of the reservoirs helps reduce risks and uncertainties associated with carbon …

Development Of High-Performance Basalt Fiber-Reinforced Polymer Composite Using A Nanocellulose-Based Surface Modification Strateg, Abdulrahman Adeiza Musa, Junha Park, Gonui Hong, Soon Ho Yoon, Azikiwe Peter Onwualu, Minkook Kim

All Rsif Scholars' Publications

Basalt fibers (BFs) have emerged as a promising alternative reinforcement material for developing fiberreinforced polymer (FRP) composites, due to their lower environmental impact compared with traditional fibers such as carbon and glass. However, the weak interfacial bonding between BFs and the polymer matrix limits the mechanical performance of basalt fiber-reinforced polymers (BFRPs). In this work, nanocelluloses (NCs), including cellulose nanofiber (CNF) and cellulose nanocrystal (CNC), were investigated as bio-based interfacial modifiers to enhance fiber–matrix adhesion and improve the mechanical performance of BFRP. While direct incorporation of NC into epoxy resin is challenging due to its poor dispersibility in hydrophobic media, …

Mechanistic Insights Into Nigerian Lithium Ores: Implications For Energy And Industrial Applications, Seun Isaiah Olajuyi, Hassan Adamu Abubakar, O. S Ogunmodimu, D. O . Afolayan

All Rsif Scholars' Publications

Lithium is a critical element in battery technology for renewable energy storage applications. The mineral offers potential solutions to the current surge in global energy demand and can position Nigeria as a potential key player in the lithium supply chain. However, little to nothing is known of the lithium deposits in Nigeria. This review explores the formation, geology, and ongoing exploration activities of lithium in Nigeria. The study provides an overview of the geological settings and mineralogical characteristics of the Nigerian lithium-bearing pegmatites and ores, comparing them with global deposits. It also examines current lithium mining and processing techniques, identifies …

Using Public Nuisance Litigation To Address Industrywide Misconduct: Common-Law Statutes, Nondelegation, And Regulation, Hillel Y. Levin, Timothy D. Lytton

Scholarly Works

In this Article, we assert that broad, open-ended public nuisance statutes offer a legitimate legal tool to curb public health harms caused by the unreasonable design, marketing, and distribution practices of product manufacturers. We argue that these statutes are "common-law statutes" by which legislatures authorize courts to apply the concept of public nuisance to new situations using common-law-style reasoning. We demonstrate that this understanding of public nuisance statutes is consistent with well-established interpretive traditions regarding the codification of common law. Statutory delegation of broad interpretive discretion to courts concerning the application of public nuisance law constitutes a legislative choice to …

Charting New Frontiers: A Legal Literature Review Of Social Entrepreneurship And Impact Investing 2018–2023, Anne M. Tucker, Deborah Burand

Scholarly Works

This Article surveys 177 articles published in U.S. law reviews and journals between 2018–2023 that contribute to the fields of social enterprise, social finance and impact investing. The Article extends our earlier legal literature review of the same fields from 2007-2017.Our collective 17-year review of this span of legal literature documents the legal issues examined by scholars with respect to the development of sophisticated alternative business forms, like the Delaware Public Benefit Corporation; the growth in impact investing; the enduring academic interest in corporate purpose; and the effects that developments related to ESG and corporate sustainability are having on the …

“Take Eight Bits And Call Me In The Morning” Video Games, Well-Being, And The Psychology Of Nostalgia, Nicholas Bowman

Media Studies - All Scholarship

For nearly 60 years, video games have arrested the attention of players, inviting us to interact and interface with on-screen content. More than just short-term entertainment experiences, video games are part of a broader cultural milieu—they are the most profitable media entertainment sector (global revenues nearly $400 billion USD in 2023) with more than 3.5 billion players globally (Clement, 2023). Similar to other entertainment media, some video game intellectual properties have transcended generations and, in many cases, grown beyond the medium itself: common cultural touchstones include Super Mario Bros. and Sonic the Hedgehog, along with seemingly endless subcultures of devoted …

What Lawyers Could Learn From The Corporate Practice Of Medicine, Melissa D. Mortazavi

Faculty Articles

Proponents of the United States’ domestic experiments in non-lawyer ownership (NLO) of legal practice justify them in terms of increasing “access to justice.” But what if opening ownership of legal practice to investment capital only exacerbates market failures (leading to further consolidation and increased costs to clients), while also compromising professional autonomy and fiduciary duty? The legal profession must be clear-eyed about who are the real winners and losers of such a shift and avoid being blinded by wishful thinking. Prominent legal scholars have repeatedly touted NLO as a solution to the access to justice crisis. However, there is scant …

Artificial Intelligence And The Hipaa Privacy Rule: A Primer, Stacey A. Tovino

Faculty Articles

No abstract provided.

An Unreliable Reporter, Jon J. Lee

Faculty Articles

As part of the legal profession’s tradition of self-regulation, attorneys have an ethical obligation to ensure that those within it are fit to practice. Given the gravity associated with accusing another lawyer of misconduct, it is not surprising that many are reticent to speak up. But what would happen if attorneys were pressured to vigorously pursue sanctions against their opponents, even if those sanctions may be unwarranted? President Trump’s recently-issued memorandum arguably does just that, mandating the Attorney General to seek court and disciplinary sanctions for lawyers and law firms that appear to violate ethics rules. This Essay explains how …

The First Amendment, Global Corporate Responsibility Standards, & The Quest For Online "Speech Nirvana", Evelyn Aswad

Faculty Articles

With large and powerful social media companies operating as worldwide speech regulators, it is unsurprising that governments have attempted to not only regulate how these companies address platform speech but also pressure them to deliver preferred speech outcomes. In 2024, the Supreme Court decided two cases addressing both themes in the U.S. context. In Moody v. NetChoice, the Court explained how legislation regulating private platform curation of usergenerated content runs afoul of First Amendment protections. And, in Murthy v. Missouri, the Court appeared to erect significant hurdles to challenging alleged governmental coercion of such platforms. These cases have left many …