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2025

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The Problem Of Being The Problem: Creating Practice-Based Fieldworking Along Climate Vulnerable Coastlines, Kate Paxman Jan 2025

The Problem Of Being The Problem: Creating Practice-Based Fieldworking Along Climate Vulnerable Coastlines, Kate Paxman

School of Art, Design and Architecture Theses

Focused on multisensory encounter with local semi-flooded sea caves and their communities in the crowded shores of Torbay’s Marine Conservation Zone, South West UK, this thesis questions how art and writing, made out of art-based practices of fieldworking (Crone et al., 2022), can respond to the threats posed to climate vulnerable coastal habitats from the global phenomenon of sea level rise. It asks, what is response, and how does an approach emerge from bodily encounters with fragile marine cave ecologies . Enquiring how acts of prolonged noticing can bear witness, the research considers what it means to be human in …


Artist Designed Systems In Community Radio, Lucinda Guy Jan 2025

Artist Designed Systems In Community Radio, Lucinda Guy

School of Art, Design and Architecture Theses

Skylark is a full-time licensed radio station, founded by the author of this thesis. Since 2020 it has broadcast a continuous and ever-changing sound installation, rejecting the conventional radio schedules of presenters, programmes, music tracks, adverts etc. Its content is drawn from contributors within Dartmoor National Park, and includes oral histories, music, poems, field recordings, archive material and fragments of bespoke music. Skylark is also a public service and research project that intends to offer an innovative way forward for community radio in the UK. Such stations are intended to respond to their locations, include multiple voices, and be not-for-profit. …


The Resistant Body In Sound: Cripping Music Creation Through Technology, Embodiment, And Disability Philosophy, Amble Ysgawen-Skuse Jan 2025

The Resistant Body In Sound: Cripping Music Creation Through Technology, Embodiment, And Disability Philosophy, Amble Ysgawen-Skuse

School of Art, Design and Architecture Theses

We are currently in a period where many music organisations are beginning to engage with disabled artists as a part of their diversity agenda. However, practice seems limited to questions of physical access to spaces and asks little around the philosophies of disability and how that might change the way that we think about working with disabled creatives. If issues of physical access are all that are taken into consideration we risk creating projects which embed ableists assumptions and practices into our disabled music making, which results in negative experiences for disabled artists. In order to make the progression of …


Investigating Trauma-Informed Practices Impact On Teacher Well-Being And Burnout, Philip Walter Schonebaum Jan 2025

Investigating Trauma-Informed Practices Impact On Teacher Well-Being And Burnout, Philip Walter Schonebaum

Dissertations and Theses

Trauma-informed practices are a way to reduce the negative impacts of trauma without retraumatizing trauma victims (SAMHSA, 2014). Using trauma-informed training for staff, this study herein sought out to examine the overall impacts on utilizing trauma-informed care strategies on teacher well-being and burnout. The action research project, relying on qualitative data collection techniques, was an immersive approach to impact change in the educational landscape of a small, rural school district. Findings showed implementing trauma-informed practices in the school district led to a greater job satisfaction, reduced stress, and a sense of camaraderie with the students within the school. This study …


Educational Trouble In Paradise: Student Perception Of Teaching Behaviors And It's Relation To Intrinsic Motivation And Academic Achievement, David Mchale Davis Jan 2025

Educational Trouble In Paradise: Student Perception Of Teaching Behaviors And It's Relation To Intrinsic Motivation And Academic Achievement, David Mchale Davis

Dissertations and Theses

Grounded in self-determination theory, this study explored students’ perceptions of provision of choice, teacher feedback, and emotional support, and how these teaching behaviors relate to intrinsic motivation and academic achievement. This study is a cross-sectional survey design and has data from 197 public high school students in the Bahamas. Path analysis was used to evaluate a model in which the three teaching behaviors predicted intrinsic motivation, which in turn was hypothesized to mediate their effects on academic achievement, measured by GPA, math grade, and students’ perceived likelihood of graduating. Results supported the model, indicating that higher levels of perceived teacher …


Social-Emotional Learning In Out-Of-School Time Settings: A Mixed Methods Investigation Of Perceived Need, Kaitlin Halbert Jan 2025

Social-Emotional Learning In Out-Of-School Time Settings: A Mixed Methods Investigation Of Perceived Need, Kaitlin Halbert

Dissertations and Theses

This study examines the integration of Social and Emotional Learning (SEL) into Out-of-School Time (OOST) settings. It evaluates the perceived need for SEL curricula among OOST professionals, highlights potential benefits and barriers to implementation, and identifies necessary adaptations to tailor these programs for the unique OOST environment. Using a mixed-methods explanatory sequential design, including surveys (BIRS, URP-NEEDS, URP-IR) completed by 115 OOST providers and interviews with 10 providers, the research analyzes both quantitative and qualitative data. The results demonstrate a strong consensus among OOST professionals on the importance and value of SEL, acknowledging its potential to enhance student behavior, social …


An Exploration Of The Experiences And Factors Influencing Physical Activity In People With Parkinsons, Heather Hunter Jan 2025

An Exploration Of The Experiences And Factors Influencing Physical Activity In People With Parkinsons, Heather Hunter

School of Health Professions Theses

Abstract:Background: Physical activity plays a crucial role in enhancing the well-being and quality of life of people with Parkinsons. Despite substantial evidence supporting its benefits, people with Parkinson’s struggle to maintain an active lifestyle. This thesis explored the perspective of people with Parkinsons on their engagement in physical activity.Methodology: This research employed a person-centred approach, comprised of three sequential phases. Phase One: A systematic review utilising the JBI approach of meta-aggregation synthesised the best available qualitative evidence of people with Parkinson's' views and preferences regarding physical activity interventions. Phase Two: Constructive Grounded Theory was used to explore the beliefs, attitudes, …


Home-Based High-Intensity Interval Training For People With Parkinson’S : The Hiit-Home4parkinson’S Study, Conrad Harpham Jan 2025

Home-Based High-Intensity Interval Training For People With Parkinson’S : The Hiit-Home4parkinson’S Study, Conrad Harpham

School of Health Professions Theses

BackgroundExercise, particularly of high intensity, is considered to be important for people with Parkinson’s (PwP). However, PwP are less active than healthy individuals, and face disease specific and logistical barriers to exercise participation such as lack of outcome expectation, symptom exacerbation, travel logistics due to motor symptoms, expense and perceived lack of time. High-intensity interval training (HIIT) is a low volume exercise modality, evinced to be beneficial and time efficient for people within various healthy and clinical populations. HIIT therefore, particularly undertaken in the home could be apposite for PwP, although evidence is currently limited. Therefore, this study aimed to …


Llms Enhance Emotional Expression While Maintaining Analytical Depth In News Writing, Samuel Mazzone, Jonah Harlan, Larry Zhiming Xu, Terence T. Ow Jan 2025

Llms Enhance Emotional Expression While Maintaining Analytical Depth In News Writing, Samuel Mazzone, Jonah Harlan, Larry Zhiming Xu, Terence T. Ow

Management Faculty Research and Publications

As the impact of generative artificial intelligence (GenAI) becomes increasingly evident in automated journalism, leveraging its potential while mitigating the risks becomes a priority in research. To address this need, our study evaluated the performance of large language models (LLMs) in news writing. We tested 11 LLMs by having them rewrite headlines and content from articles published by Milwaukee Neighborhood News Service (NNS) between 2011 and 2023. The analysis and comparison of 3,623 human-written and 39,853 AI-adapted news pieces showed that different LLMs consistently enhanced emotional expression in headlines (Cohen’s d = .33) and in news content (Cohen’s d = …


Tourists’ Immersive Experiences At Dark Tourism Destinations: The Role Of The Spiritualist Medium, Andrew Fry Jan 2025

Tourists’ Immersive Experiences At Dark Tourism Destinations: The Role Of The Spiritualist Medium, Andrew Fry

Plymouth Business School Theses

While immersive experience and dark tourism are established fields, little research has examined how spiritualist mediums shape belief-led, emotionally resonant encounters at historically charged sites. This thesis addresses that gap by investigating how mediums influence emotional engagement, interpretive depth, and perceptions of authenticity. Centred on Bodmin Jail’s After Dark Event, the study adopts a sequential mixed-methods design and integrates quantitative patterns with qualitative mechanisms through joint QUAN–QUAL displays. Findings show that mediumship helps convert arousal into reflective meaning through ritual participation, atmospheric design, and interpretive trust. Anticipated theatricality heightened arousal and “staging” attributions, yet felt authenticity was sustained when the …


Graduate Catalog 2025-2026, Southwestern Oklahoma State University Jan 2025

Graduate Catalog 2025-2026, Southwestern Oklahoma State University

Graduate Catalogs

No abstract provided.


Havana Syndrome: A Scientific Review Of An Unresolved Medical Mystery, Aishik Dutta Jan 2025

Havana Syndrome: A Scientific Review Of An Unresolved Medical Mystery, Aishik Dutta

Digital Journal of Clinical Medicine

Background

Since 2016, U.S. and Canadian officials have reported Anomalous Health Incidents (AHIs), or "Havana Syndrome," characterised by a strange sensory experience followed by chronic neurological, cognitive, and vestibular issues. The cause is intensely debated, with primary hypotheses pointing to either psychosocial factors or a directed-energy weapon, creating a significant medical and geopolitical puzzle.

Methods

This review critically assesses the current evidence by analysing peer-reviewed clinical studies and major institutional reports.

Results

The findings are deeply contradictory. A 2020 NASEM report identified directed, pulsed radiofrequency energy as the most plausible mechanism for a core set of symptoms. Conversely, comprehensive 2024 …


Shaping Pakistan's Future, Sdsb 360 Magazine Jan 2025

Shaping Pakistan's Future, Sdsb 360 Magazine

Faculty Research - Newspaper and Magazine Articles

SDSB 360 is in conversation with Dr. Ishrat Husain, an influential Pakistani banker, economist, and reformer whose leadership has shaped Pakistan’s financial landscape. From steering the State Bank of Pakistan (1999–2006) to driving educational excellence as Dean of IBA Karachi (2008–2016) and championing institutional reforms as Advisor to the Prime Minister (2018–2022), Dr. Husain’s career is a testament to visionary leadership and a relentless pursuit of progress.


Afit Generative Ai Teaching Guidebook, Afit Faculty Learning Community, Mark G. Bateman, Brett J. Borghetti, Allen W. Dukes, Nicholas C. Francis, Mike Frick, Bobbie Oh, Kevin Patterson, Hiren J. Patel, Mark G. Reith, Erick S. Tyndall, Teresa M. Walton, Torrey J. Wagner, Timothy S. Wolfe, Jonathan Zemmer Jan 2025

Afit Generative Ai Teaching Guidebook, Afit Faculty Learning Community, Mark G. Bateman, Brett J. Borghetti, Allen W. Dukes, Nicholas C. Francis, Mike Frick, Bobbie Oh, Kevin Patterson, Hiren J. Patel, Mark G. Reith, Erick S. Tyndall, Teresa M. Walton, Torrey J. Wagner, Timothy S. Wolfe, Jonathan Zemmer

AFIT Documents

AFIT is proud to highlight the Generative AI Teaching Guidebook, a resource designed to provide military educators with practical insights, strategies, and use cases for integrating Generative AI (Gen AI) into their teaching practices. Developed through a collaborative effort involving AFIT faculty across various departments within the Graduate School of Engineering and Management and the School of Systems and Logistics, this digital resource serves as a starting point for educators exploring how to leverage Gen AI in their classrooms. It offers accessible examples and best practices, ensuring utility for instructors of all technical backgrounds. The guidebook provides a comprehensive overview …


A Comprehensive Exploration Of 6g Wireless Communication Technologies, Md Nurul Absar Siddiky, Muhammad Enayetur Rahman, Md. Shahriar Uzzal, H. M. Dipu Kabir Jan 2025

A Comprehensive Exploration Of 6g Wireless Communication Technologies, Md Nurul Absar Siddiky, Muhammad Enayetur Rahman, Md. Shahriar Uzzal, H. M. Dipu Kabir

Electrical & Computer Engineering Faculty Publications

As the telecommunications landscape braces for the post-5G era, this paper embarks on delineating the foundational pillars and pioneering visions that define the trajectory toward 6G wireless communication systems. Recognizing the insatiable demand for higher data rates, enhanced connectivity, and broader network coverage, we unravel the evolution from the existing 5G infrastructure to the nascent 6G framework, setting the stage for transformative advancements anticipated in the 2030s. Our discourse navigates through the intricate architecture of 6G, highlighting the paradigm shifts toward superconvergence, non-IP-based networking protocols, and information-centric networks, all underpinned by a robust 360-degree cybersecurity and privacy-by-engineering design. Delving into …


Ml Model To Better Identify Instances Of Bullying Faced By Members Of The Lgbtq+ Community, Arslan Bisharat Jan 2025

Ml Model To Better Identify Instances Of Bullying Faced By Members Of The Lgbtq+ Community, Arslan Bisharat

Master's Theses

Cyberbullying poses a significant threat to online communities, with the LGBTQ+ community facing disproportionately higher rates of harassment. While existing cyberbullying detection systems have made progress in identifying general instances of online harassment, they often fail to capture the nuanced and context-dependent nature of LGBTQ+-targeted bullying. This thesis presents a novel approach to this challenge by developing SpectrumNet, an LGBTQ+-centric transformer-based model for cyberbullying detection. Our research was conducted in two phases. In Phase 1, we evaluated the effectiveness of pre-trained transformer models (RoBERTa, BERT, and GPT-2) in identifying LGBTQ+-related cyberbullying. Building on these findings, Phase 2 introduced SpectrumNet which …


A Qualitative Analysis Of Open Banking In Poland: The Perspective Of Market Experts, Sylwia Ciechanowska Jan 2025

A Qualitative Analysis Of Open Banking In Poland: The Perspective Of Market Experts, Sylwia Ciechanowska

Studia i Materiały Wydział Zarządzania Uniwersytet Warszawski

Purpose: The purpose of this article is to present an in-depth analysis of the development of open banking in Poland based on interviews conducted with market experts representing financial institutions and regulatory authorities. The article identifies both the benefits and implementation barriers of open banking, with particular emphasis on the quality of APIs (application programming interfaces), system interoperability, and the impact of regulatory frameworks on service innovation and security.

Methodology: This qualitative study was conducted using structured interviews with market experts representing banks, fintech companies, regulatory authorities, and independent industry consultants. The selection of experts was purposive, with …


Setting The Stage For Success: Readiness And Connectedness As Antecedents Of Learning Continuance Intention In Online Learning, Yingqi Tang, Hungwei Tseng, Yu-Chun Kuo, Hsin-Te Yeh, Jianfang Liu Jan 2025

Setting The Stage For Success: Readiness And Connectedness As Antecedents Of Learning Continuance Intention In Online Learning, Yingqi Tang, Hungwei Tseng, Yu-Chun Kuo, Hsin-Te Yeh, Jianfang Liu

Research, Publications & Creative Work

Through a hierarchical multiple regression analysis, this study investigated how dimensions of online learning readiness and online connectedness influence students’ intentions to continue to take online courses. Data from 369 students who took at least one online course at a four-year public university showed that online learning readiness had a stronger relationship with continuance intention than online student connectedness, while online learning readiness had a significant correlation with online student connectedness. Online learning readiness and connectedness were indicators of online learning persistence. Factors such as age, computer/internet self-efficacy, self-directed learning, learner control, and facilitation influence students' intention to continue with …


Skinned Worlds: Virtual Reality And The Postbiological, Alicia Corts Jan 2025

Skinned Worlds: Virtual Reality And The Postbiological, Alicia Corts

Research, Publications & Creative Work

This paper explores the concept of “skinning” in educational virtual reality (VR) environments, reframing it as a dramaturgical and pedagogical act rather than a mere visual overlay. Through comparative analysis of The World of Hugo Simberg and C!ao: Piazza Navona Experience, the study investigates how design decisions shape user identity, agency, and the performance of learning. Drawing on performance theory, it examines how avatars – or their absence – guide learners through curated paths, subtly influencing perception and interaction. While both applications strip away overt self-representation, they open space for subversion, reflection, and imaginative engagement. The paper argues that skinning …


Upregulation Of Delta Opioid Receptor By Meningeal Interleukin-10 Prevents Relapsing Pain, Kufreobong E Inyang, Jaewon Sim, Kimberly B Clark, Matan Geron, Karli Monahan, Christine Evans, Patrick O'Connell, Sophie Laumet, Bo Peng, Jiacheng Ma, Cobi J Heijnen, Robert Dantzer, Grégory Scherrer, Annemieke Kavelaars, Matthew Bernard, Yasser A Aldhamen, Joseph K Folger, Alexis Bavencoffe, Geoffroy Laumet Jan 2025

Upregulation Of Delta Opioid Receptor By Meningeal Interleukin-10 Prevents Relapsing Pain, Kufreobong E Inyang, Jaewon Sim, Kimberly B Clark, Matan Geron, Karli Monahan, Christine Evans, Patrick O'Connell, Sophie Laumet, Bo Peng, Jiacheng Ma, Cobi J Heijnen, Robert Dantzer, Grégory Scherrer, Annemieke Kavelaars, Matthew Bernard, Yasser A Aldhamen, Joseph K Folger, Alexis Bavencoffe, Geoffroy Laumet

Faculty, Staff and Student Publications

Chronic pain often includes periods of transient amelioration and even remission that alternate with severe relapsing pain. While most research on chronic pain has focused on pain development and maintenance, there is a critical unmet need to better understand the mechanisms that underlie pain remission and relapse. We found that interleukin (IL)-10, a pain resolving cytokine, is produced by resident macrophages in the spinal meninges during remission from pain and signaled to IL-10 receptor-expressing sensory neurons. Using unbiased RNA-sequencing, we identified that IL-10 upregulated expression and antinociceptive activity of δ-opioid receptor (δOR) in the dorsal root ganglion. Genetic or pharmacological …


Not Fully Synthetic: Llm-Based Hybrid Approaches Towards Privacy-Preserving Clinical Note Sharing, Atiquer Rahman Sarkar, Yao-Shun Chuang, Xiaoqian Jiang, Noman Mohammed Jan 2025

Not Fully Synthetic: Llm-Based Hybrid Approaches Towards Privacy-Preserving Clinical Note Sharing, Atiquer Rahman Sarkar, Yao-Shun Chuang, Xiaoqian Jiang, Noman Mohammed

Faculty, Staff and Student Publications

The publication and sharing of clinical notes are crucial for healthcare research and innovation. However, privacy regulations such as HIPAA and GDPR pose significant challenges. While de-identification techniques aim to remove protected health information, they often fall short of achieving complete privacy protection. Similarly, the current state of synthetic clinical note generation can lack nuance and content coverage. To address these limitations, we propose an approach that combines de-identification, filtration, and synthetic clinical note generation. Variations of this approach currently retain 36%-61% of the original note's content and fill the remaining gaps using an LLM, ensuring high information coverage. We …


Neutrophils Unveiled In Chronic Lymphocytic Leukemia, Sheighlah Mcmanus, Priyanka Khare, Maria Teresa S Bertilaccio Jan 2025

Neutrophils Unveiled In Chronic Lymphocytic Leukemia, Sheighlah Mcmanus, Priyanka Khare, Maria Teresa S Bertilaccio

Faculty, Staff and Student Publications

This review explores neutrophils' roles in chronic lymphocytic leukemia (CLL), highlighting their functions within the immune system. While neutrophils are known for fighting infections, their altered behavior in CLL significantly impacts disease progression. This review notes the reduced phagocytic abilities of neutrophils and the increased formation of neutrophil extracellular traps (NETs) in patients with CLL. It also examines the effects of CLL treatments, including chemotherapy, immunotherapy and targeted therapies, on neutrophils' count and function, stressing the need for improved strategies to manage therapy-induced immune dysfunction. This review also provides detailed information about the interactions between neutrophils and other immune elements …


Role Of Mir-204 In Controlling Metabolic Functions Of The Subretinal Microglia, Yan Chen, Sarah E Bounds, Neloy Kundu, James Regun Karmoker, Yin Liu, Dongin Kim, Jiyang Cai Jan 2025

Role Of Mir-204 In Controlling Metabolic Functions Of The Subretinal Microglia, Yan Chen, Sarah E Bounds, Neloy Kundu, James Regun Karmoker, Yin Liu, Dongin Kim, Jiyang Cai

Faculty, Staff and Student Publications

Rationale: MicroRNA-204 (miR-204) is one of the most abundant miRNA species in the retinal pigment epithelium (RPE) and RPE-derived extracellular vesicles (EVs). Knockout (KO) of miR-204 leads to dysfunction and degeneration of both the RPE and the retina. In addition to previously reported retinal pathologies, we observed the accumulation of lipid-laden subretinal microglia in miR-204 KO mice. This study aimed to identify potential molecular targets of miR-204 involved in microglia lipid processing and to determine whether RPE-derived EVs can improve the function of miR-204-deficient retinal microglia.

Methods: Lipid accumulation in microglia was detected by staining with LipidTox, a fluorescent dye …


Combined Inhibition Of Lysine-Specific Demethylase 1 And Kinase Signaling As A Preclinical Treatment Strategy In Glioblastoma, Lea M Stitzlein, Deokhwa Nam, Faith A Hernandez, Kareena H Patel, Alaina Poche, Huaxian Ma, Katie Impelman, Joy Gumin, Heping Wang, Jing Wang, Samantha Gadd, Wafik Zaky, Oren Becher, Richard W Dudley, Frederick F Lang, Gangadhara R Sareddy, Joya Chandra Jan 2025

Combined Inhibition Of Lysine-Specific Demethylase 1 And Kinase Signaling As A Preclinical Treatment Strategy In Glioblastoma, Lea M Stitzlein, Deokhwa Nam, Faith A Hernandez, Kareena H Patel, Alaina Poche, Huaxian Ma, Katie Impelman, Joy Gumin, Heping Wang, Jing Wang, Samantha Gadd, Wafik Zaky, Oren Becher, Richard W Dudley, Frederick F Lang, Gangadhara R Sareddy, Joya Chandra

Faculty, Staff and Student Publications

Background: Lysine-specific demethylase 1 (LSD1) is overexpressed in glioblastoma, contributing to tumor growth and treatment resistance. LSD1 inhibitors have shown preclinical promise but have had limited clinical development for glioblastoma. Given the frequent kinase pathway alterations seen in glioblastoma, the interplay between LSD1 inhibition and kinase signaling pathways was investigated.

Methods: Glioblastoma stem cell (GSC) lines and normal human astrocytes (NHAs) were treated with catalytic LSD1 inhibitors, NCD38 and bomedemstat, and the LSD1 scaffolding inhibitor, seclidemstat alone and in combination with kinase inhibitors, including osimertinib, afatinib, and ulixertinib. The effect on cell viability, proliferation, and neurosphere formation was assessed, and …


Relationship Between Trpm4 Rs8104571 Genotype, Circulating Trpm4 And Sur1, And Clinical Outcome Following Traumatic Brain Injury, Joseph D Krocker, Madeline E Cotton, Janet R Ashley, Jacob B Schriner, Baron K Osborn, Yao-Wei Willa Wang, Charles S Cox, Charles E Wade Jan 2025

Relationship Between Trpm4 Rs8104571 Genotype, Circulating Trpm4 And Sur1, And Clinical Outcome Following Traumatic Brain Injury, Joseph D Krocker, Madeline E Cotton, Janet R Ashley, Jacob B Schriner, Baron K Osborn, Yao-Wei Willa Wang, Charles S Cox, Charles E Wade

Faculty, Staff and Student Publications

The variant single nucleotide polymorphism rs8104571 has been associated with poor outcomes following traumatic brain injury (TBI) and is most prevalent in those of African ancestry. This single nucleotide polymorphism (SNP) resides within a gene coding for the TRPM4 protein, which complexes with SUR1 protein to create a transmembrane ion channel and is believed to contribute to cellular swelling and cell death in neurological tissue. Our study evaluates the relationship between circulating TRPM4 and SUR1, rs8104571 genotype, and clinical outcome in TBI patients. Trauma patients with moderate to severe TBI were included in this retrospective study. rs8104571 genotyping and admission …


Correction: Bronchoalveolar Lavage Cell Percentages As Diagnostic Markers Of Immune Checkpoint Inhibitor Pneumonitis, Mahnoor Mir, Felipe Soto, Pedro Antonio Amezcua Gomez, Rodrigo Del Rio Arroyo, Adarsh Suresh, Amber Su, Qiong Gan, John Stewart, Roberto Adachi, Diwakar D Balachandran, Lara Bashoura, Roberto F Casal, Burton F Dickey, George A Eapen, Scott E Evans, Horiana Grosu, Carlos A Jimenez, Julie Lin, David E Ost, Bruce F Sabath, Vickie R Shannon, Aung Naing, Jianjun Gao, Jia Wu, Karthik Suresh, Saadia A Faiz, Mehmet Altan, Ajay Sheshadri Jan 2025

Correction: Bronchoalveolar Lavage Cell Percentages As Diagnostic Markers Of Immune Checkpoint Inhibitor Pneumonitis, Mahnoor Mir, Felipe Soto, Pedro Antonio Amezcua Gomez, Rodrigo Del Rio Arroyo, Adarsh Suresh, Amber Su, Qiong Gan, John Stewart, Roberto Adachi, Diwakar D Balachandran, Lara Bashoura, Roberto F Casal, Burton F Dickey, George A Eapen, Scott E Evans, Horiana Grosu, Carlos A Jimenez, Julie Lin, David E Ost, Bruce F Sabath, Vickie R Shannon, Aung Naing, Jianjun Gao, Jia Wu, Karthik Suresh, Saadia A Faiz, Mehmet Altan, Ajay Sheshadri

Faculty, Staff and Student Publications

[This corrects the article DOI: 10.3389/fmed.2025.1582714.].


Neuroprotective Role Of Ding Protein In Fetal Alcohol Spectrum Disorders And Depression, Nune Darbinian, Monica Hampe, Nana Merabova, Tamara Tatevosian-Geller, Laura Goetzl, Mary F Morrison, Gabriel Tatevosian, Malgorzata Simm, Eric Chabriere, Huaqing Zhao, Shohreh Amini, Michael E Selzer Jan 2025

Neuroprotective Role Of Ding Protein In Fetal Alcohol Spectrum Disorders And Depression, Nune Darbinian, Monica Hampe, Nana Merabova, Tamara Tatevosian-Geller, Laura Goetzl, Mary F Morrison, Gabriel Tatevosian, Malgorzata Simm, Eric Chabriere, Huaqing Zhao, Shohreh Amini, Michael E Selzer

Faculty, Staff and Student Publications

Introduction: An estimated 20% of women consume alcohol during pregnancy, and 10% of women receive antidepressants during their pregnancy. Women with depression are more likely to use alcohol (EtOH) in early pregnancy and are more likely to have a child with one of the fetal alcohol spectrum disorders (FASD). Previously, we provided evidence in rat neurons in vitro that DING phosphatase (p38SJ, a member of the DINGGG family of proteins that has neuroprotective effects under conditions of cellular stress) was neuroprotective against EtOH-mediated toxicity. Now, we examine the effects of DING, alone or in combination with EtOH and serotonergic (5-HT) …


Temporal Ensemble Logic For Integrative Representation Of The Entirety Of Clinical Trials, Xiaojin Li, Yan Huang, Rashmie Abeysinghe, Zenan Sun, Hongyu Chen, Pengze Li, Xing He, Shiqiang Tao, Cui Tao, Jiang Bian, Licong Cui, Guo-Qiang Zhang Jan 2025

Temporal Ensemble Logic For Integrative Representation Of The Entirety Of Clinical Trials, Xiaojin Li, Yan Huang, Rashmie Abeysinghe, Zenan Sun, Hongyu Chen, Pengze Li, Xing He, Shiqiang Tao, Cui Tao, Jiang Bian, Licong Cui, Guo-Qiang Zhang

Faculty, Staff and Student Publications

Clinical trials are typically specified with protocols that define eligibility criteria, treatment regimens, follow-up schedules, and outcome assessments. Temporality is a hallmark of all clinical trials, reflected within and across trial components, with complex dependencies unfolding across multiple time points. Despite their importance, clinical trial protocols are described in free-text format, limiting their semantic precision and the ability to support automated reasoning, leverage data across studies and sites, or simulate trial execution under varying assumptions using Real-World Data. This paper introduces a formalized representation of clinical trials using Temporal Ensemble Logic (TEL). TEL incorporates metricized modal operators, such as “always …


Non-Invasive Measurement Of Elasticity In Glioblastoma Multiforme Validates Decreased Tmz Sensitivity In Astrocyte Co-Culture, Megan Mendieta, Maryam Hatami, Manmohan Singh, Sajedeh Saeidi Fard, Mohammad Dehshiri, Alexander Schill, Dmitry Nevozhay, Salavat Aglyamov, Bulent Ozpolat, Konstantin V Sokolov, Yasemin M Akay, Kirill V Larin, Metin Akay Jan 2025

Non-Invasive Measurement Of Elasticity In Glioblastoma Multiforme Validates Decreased Tmz Sensitivity In Astrocyte Co-Culture, Megan Mendieta, Maryam Hatami, Manmohan Singh, Sajedeh Saeidi Fard, Mohammad Dehshiri, Alexander Schill, Dmitry Nevozhay, Salavat Aglyamov, Bulent Ozpolat, Konstantin V Sokolov, Yasemin M Akay, Kirill V Larin, Metin Akay

Faculty, Staff and Student Publications

Goal: In this research, we investigated the changes in elasticity of in vitro glioblastoma multiforme (GBM) spheroids when treated with the gold standard chemotherapy for GBM, Temozolomide (TMZ). Additionally, we aimed to use this alternative biomarker to assess how modifying the tumor microenvironment (TME) with the addition of human astrocytes (HA) would influence treatment efficacy. Methods: Spheroid stiffness was investigated using advanced non-invasive optical techniques, nanobomb optical coherence elastography (nb-OCE) and Brillouin microscopy to obtain new biomechanical insights by assessing local tumor progression or response to therapy using GBM cells (LN229). Results: The treated monocultured GBM groups showed a significant …


Long-Term Symptom Burden In A Young, Ambulatory Cohort After The Omicron Outbreak In China, Simeng Ren, Yumeng Tan, Hongkun Xu, Mian Wang, Rumei Xiang, Jiayue Jin, Baojin Han, Jiaheng Shi, Jingyu Zhang, Jinliang Yang, Xin Tian, Ying Li, Jiaojiao Chen, Wenzheng Zhang, Jingqi Yang, Xin Shelley Wang, Qiuling Shi, Jie Liu Jan 2025

Long-Term Symptom Burden In A Young, Ambulatory Cohort After The Omicron Outbreak In China, Simeng Ren, Yumeng Tan, Hongkun Xu, Mian Wang, Rumei Xiang, Jiayue Jin, Baojin Han, Jiaheng Shi, Jingyu Zhang, Jinliang Yang, Xin Tian, Ying Li, Jiaojiao Chen, Wenzheng Zhang, Jingqi Yang, Xin Shelley Wang, Qiuling Shi, Jie Liu

Faculty, Staff and Student Publications

Introduction: At the end of 2022, an outbreak of the Omicron BF.7 and BA.5.2 subvariants of SARS-CoV-2 occurred in China. In this prospective cohort study, we investigated the pattern of development of major symptom burden and influencing factors in infected Chinese patients.

Methods: First-time infected outpatients were enrolled from December 7, 2022, to January 11, 2023 (N = 355). The prevalence of symptoms was monitored by a repeated patient-reported quantitative symptom survey over nine months.

Results: At the onset of the infection, the most prevalent symptoms (score ≥1 on a 0-10 numeric rating scale) were fatigue (91.8%), cough (91.8%), …