Digital Commons Network^™

Comparison Of Hepcidin-25 And Angiogenin (Rnase-5) Levels In Healthy Children And Children With Brucellosis, Ümmü Seleme Mumcu, Özge Metin Akcan, Mehmet Özdemir, Gökçe Kader Arslan, Mustafa Gençeli

Journal of Pediatric Infectious Diseases

Objective: The aim of this study is to determine whether there is a change in serum levels of the anti-microbial peptides Hepcidin-25 and angiogenin, in pediatric patients with Brucellosis compared to healthy controls. In addition, to evaluate their role in brucellosis and relationship with complications of brucellosis. Methods: In our study, children aged 3 to 18 years were included. There were 50 patients in the brucellosis group and 40 healthy children in the control group. Serum hepcidin-25 and angiogenin levels were studied, as well as complete blood count, alanine aminotransferase, aspartate aminotransferas, C-reactive protein, erythrocyte sedimentation rate. The relationship between …

Evaluation Of Kl-6 And Srage As Alveolar Damage Markers In Pediatric Covid-19 Cases: Is Srage The Key Reason For Clinical Differences In Pediatric And Adult Covid-19 Patients?, Gulsen Akkoc, Berker Okay, Sukran Ozdatli Kurtulus, Halil Ugur Hatipoglu, Eda Dilara Bay, Derya Buyukkayhan

Journal of Pediatric Infectious Diseases

Objective: KL-6 and sRAGE, produced by pneumocytes, are novel biomarkers for pulmonary diseases. These markers were found to be elevated in COVID-19 adult patients. The aim of this study was to identify a possible inflammatory biomarker for COVID-19 in children and evaluate these biomarkers to predict clinical course. Methods: Between 01.01.2021 and 31.12.2021, 61 patients (mild and moderate) and 27 control participants aged from 1 month to 18 years were included in the study, and a nonrandomized prospective case-control study was designed. KL-6 and sRAGE levels were evaluated in all participants and compared between each group. Results: The mean age …

Ezrin And Childhood Pneumonia: A Potential Marker Of Pulmonary Epithelial Damage And Inflammation, Sedef Turk, Bahadir M. Samur, Humeyra Aslaner, Didem Barlak-Keti, Emrah Turk, Mehmet Kose

Journal of Pediatric Infectious Diseases

Objective: Ezrin, also known as villin-2 or cytovillin, is a cytoplasmic peripheral membrane protein encoded in humans with the potential implications for various human cancers, cytokine modulation, cytoskeleton remodeling, mucous membrane integrity, and epithelial or pulmonary damage. This study hypothesizes that the amounts of exosome-associated ezrin in the serum detected by ELISA may correlate with the diagnosis or severity of pneumonia in children. We aimed to examine ezrin levels as a pulmonary epithelial cell damage or inflammation marker in a clinical model of pediatric pneumonia. Methods: The prospective study was conducted with 108 previously diagnosed children with pneumonia and 59 …

Ene 661 -101: Environmental Microbiology, Wen Zhang

Civil and Environmental Engineering Syllabi

No abstract provided.

Enhancing The Care Of Patients With Bone And Joint Infections Through Educational Interventions, Neel B. Shah, Jessica Seidelman, Katherine Belden, Elizabeth Thottacherry, Allison Lastinger, Priya Nori, Ronald M. Beaulieu, Don Bambino Geno Tai

Division of Infectious Diseases and Environmental Medicine Faculty Papers

Musculoskeletal infections represent a significant proportion of the clinical workload for infectious diseases (ID) providers, often presenting complex diagnostic and therapeutic challenges. Many providers may feel inadequately prepared to manage these conditions, which require a nuanced understanding of microbiology, musculoskeletal anatomy, surgical intervention, and orthopedic hardware. We implemented a pair of educational interventions including an online library of high-yield musculoskeletal ID literature and an educational podcast. © The Author(s) 2025. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Synthetic Plasmodium Antigens, Compositions, And Uses Thereof, John H. Adams, Christopher L. King, Niraj H. Tolia, Edwin Chen, Nichole Diane Salinas, Miriam Thankam George, Francis B. Ntumngia, Samantha Jones Barnes

USF Patents

Provided herein are synthetic P. vivax antigens, antibodies and pharmaceutical formulations and vaccines thereof. Also provided herein are methods of treating and/or preventing Plasmodium infection and/or disease by administering the synthetic P. vivax antigens, antibodies and pharmaceutical formulations and vaccines thereof.

Clinical Testing For Covid-19, Influenza, And Rsv In Hospitalized Youths, 2016-2024., Ariana P. Toepfer, Rachel E. Rutkowski, Leila C. Sahni, Geoffrey A. Weinberg, Marian G. Michaels, Rangaraj Selvarangan, Mary Allen Staat, Natasha Halasa, Janet A. Englund, Julie A. Boom, Peter G. Szilagyi, Jennifer E. Schuster, Elizabeth P P. Schlaudecker, Laura S. Stewart, Eileen J. Klein, Samantha M. Olson, Sascha Ellington, Meredith L. Mcmorrow, Heidi L. Moline, Fatimah S. Dawood, New Vaccine Surveillance Network Collaborators

Manuscripts, Articles, Book Chapters and Other Papers

IMPORTANCE: Studies of COVID-19, influenza, and respiratory syncytial virus (RSV) disease clinical epidemiology, disease burden, and vaccine effectiveness often rely on clinical testing to identify cases, particularly with increasing use of electronic health record data. However, few data are available describing clinical testing practices to inform interpretation of these studies.

OBJECTIVE: To characterize clinical testing frequency for SARS-CoV-2, influenza, and RSV among children and adolescents hospitalized with acute respiratory illness during the 2016 to 2024 respiratory illness seasons by age, intensive care unit admission, and time period (2016-2020 and each season in 2020-2024); estimate the case fraction missed by clinical …

Encapsulation Of Disease-Causing And Commensal Mitis Group Non-Pneumococcal Streptococci, Daniel M Musher, Mathias Müsken, M John Hicks, Lesley Mcgee, Bernard Beall

Faculty, Staff and Students Publications

Background: Mitis group non-pneumococcal streptococci (MGNPS), specifically Streptococcus mitis, Streptococcus infantis and Streptococcus oralis, have recently been shown to cause pneumonia and/or bacteremia. These organisms often have capsular (cps) operons resembling those in pneumococci, and some express cps-generated polysaccharides that antigenically cross-react with pneumococcal capsular serotypes. But, to date, a series of MGNPS isolates has not been studied by electron microscopy (EM) for the presence of a capsule.

Methods: We studied 21 MGNPS; 11 were isolated from sputum and determined to have caused pneumonia, 3 were isolated from blood, and 7 were commensal isolates cultured …

Gellan Gum Formulations Containing Natural Polyphenolic Compounds To Treat Oral Candidiasis, Narchonai Ganesan, Lewis Oscar Felix, Biswajit Mishra, Liyang Zhang, Charilaos Dellis, Fadi Shehadeh, Danielle Wu, Lissette A Cruz, R M Arce, Eleftherios Mylonakis

Faculty, Staff and Student Publications

Oral candidiasis (OC) is caused by Candida albicans, targeting immunocompromised individuals and developing drug resistance, highlighting the need for advanced therapeutics. Polyphenols such as caffeic acid phenethyl ester (CAPE) and ellagic acid (EA) display antifungal and immune-modulating properties. Incorporating CAPE and EA in gellan gum (GG) formulation enhances their applicability and effectiveness against OC. We developed GG-based formulations loaded with CAPE (1,000 µg/mL), EA (1,000 µg/mL), or CAPE + EA (1,000 µg/mL each) against C. albicans. GG formulations containing gellan (0.6% and 1.0%), genipin (5 mM), polyethylene glycol 400 (0.5%), and sorbitan monooleate 80 (0.5%) demonstrated enhanced release …

Scenario Projections Of Covid-19 Burden In The Us, 2024-2025, Sara L Loo, Sung-Mok Jung, Lucie Contamin, Emily Howerton, Samantha J Bents, Harry Hochheiser, Michael C Runge, Claire P Smith, Erica C Carcelén, Katie Yan, Joseph C Lemaitre, Emily Przykucki, Clifton D Mckee, Koji Sato, Allison L Hill, Matteo Chinazzi, Jessica T Davis, Clara Bay, Alessandro Vespignani, Shi Chen, Rajib Paul, Daniel Janies, Jean-Claude Thill, Sean M Moore, T Alex Perkins, Ajitesh Srivastava, Majd Al Aawar, Kaiming Bi, Shraddha Ramdas Bandekar, Anass Bouchnita, Spencer J Fox, Lauren Ancel Meyers, Przemyslaw Porebski, Srinivasan Venkatramanan, Bryan Lewis, Jiangzhuo Chen, Madhav Marathe, Michal Ben-Nun, James Turtle, Pete Riley, Katriona Shea, Cécile Viboud, Justin Lessler, Shaun Truelove

Faculty, Staff and Student Publications

Importance: COVID-19 remains a disease with high burden in the US, prompting continued debate about optimal targets for annual vaccination.

Objective: To project COVID-19 burden in the US for April 2024 to April 2025 under 6 scenarios of immune escape (20% and 50% per year) and levels of vaccine recommendation (no recommendation, vaccination for individuals at high risk only, vaccination for all eligible groups) and to assess the potential benefit of vaccine recommendations in reducing disease burden.

Design, setting, and participants: For this decision analytical model, the US Scenario Modeling Hub, a collaborative modeling effort, convened 9 teams to provide …

Risk Of Cardiovascular Events During Delivery Hospitalization Among Pregnant Patients With Mental Health Conditions, Kavya Parekh, R J Waken, Khavya Avula, Katelin B Nickel, Kathryn J Lindley, Cynthia Rogers, Karen E Joynt Maddox

2020-Current year OA Pubs

BACKGROUND: Cardiovascular disease remains the leading cause of maternal mortality. Mental health disorders are risk factors for cardiovascular disease in nonpregnant populations, but their association with delivery outcomes is unknown.

METHODS: This cross-sectional study used delivery hospitalizations from the 2021 National Inpatient Sample. We used generalized estimating equations to fit quasi-Poisson regression models for cardiovascular severe maternal morbidity and mortality (SMM) events as defined by the Centers for Disease Control and Prevention, and non-SMM cardiovascular conditions or complications as defined by the Alliance for Innovation on Maternal Health. Incidence rate ratios were calculated for depression, anxiety, psychosis, bipolar, obsessive-compulsive disorder, …

Gw Ophthalmology On-Call: 09/2025, Mike Nguyen, Sophie Gorup

GW Ophthalmology On-Call

No abstract provided.

Hist 213-011: The 20th Century World, Elektra Kostopoulou

History Syllabi

No abstract provided.

Math 374-001: Stochastic/Discrete Bio Models, J. Maclaurin

Mathematical Sciences Syllabi

No abstract provided.

Prosthetics In The Time Of Proust, Ashley S. Mcguire

Patent Coloring Books

Patent coloring book

Association Of Covid-19 Status With Maternal And Neonatal Outcomes Among Pregnant Women At Mombasa County Referral Hospital, Kenya, Salome Mghoi Rajab

MSc in Advanced Practice Midwifery

Background: COVID-19 pandemic has raised global concern regarding maternal and neonatal health owing to physiological and immunological changes that may heighten disease severity. Despite the global evidence linking COVID-19 infection with unfavorable pregnancy outcomes, data from Sub-Saharan Africa remain limited. This leaves an essential vacuum in our understanding of how COVID-19 status affects maternal and neonatal outcomes in counties like Mombasa, where health-care system problems may alter risks. Vertical transmission remains a puzzle to be solved.

Aim: To assess the association of COVID-19 status on maternal and neonatal outcomes between March 2020 to March 2022.

Methodology: A …

Private Functional Wildlife Trusts, Stuart W. Babcock

ACTEC Law Journal

Public wildlife law is clear: wild animals exist and are managed for the public writ large. This is a mistake. Wild animals are beings of moral concern; their lives can be good or bad, better or worse, and they should be treated accordingly. This article explores a novel legal instrument which can account for wild animals' unique interests and circumstances: private wildlife trusts, in which wild animals are the trust beneficiaries. Wildlife trusts pose distinctive management and implementation challenges. This article aims to provide a path forward for wildlife advocates seeking new tools to protect wild animals and the habitats …

Are Ai-Assisted Drug Technologies Addressing Or Aggravating The Opioid Crisis In The United States?, Abby O'Hern

West Virginia Law Review

The opioid crisis is a significant public health emergency, intensified by the rise of synthetic opioids such as fentanyl. Lawmakers have described fentanyl as “terroristic in nature” due to its often-fatal properties. According to the Center for Disease Control (“CDC”), an estimated 107,543 people died from drug overdoses in the United States in 2023. As fentanyl use has surged, it has increasingly shaped public health policy through harm reduction initiatives, expanded addiction treatment resources, and legislative reforms aimed at curbing overdose deaths. Artificial Intelligence (“AI”) now plays a dual role in this evolving crisis. While AI technologies offer valuable tools …

Hist 213-015: The 20th Century World, Elektra Kostopoulou

History Syllabi

No abstract provided.

Towards Accessibility In Healthcare For Individuals With And Without Hearing Loss: Evaluation Of Usability, Fit, And Communicative Effectiveness Of A Transparent N95 Mask Prototype, Samuel R. Atcherson, Brooklyn Schultes, Jeanne Hahne, Barbara Debaun, Chris Showell

JADARA

The COVID-19 pandemic has underscored the necessity of effective face masks in both public and healthcare settings for mitigating the spread of disease. However, traditional face masks impede communication, posing significant challenges for approximately 13% of the general population and 10% of healthcare and social assistance workers who have hearing loss and who rely on lipreading and other non-verbal cues. Traditional surgical masks and N95 respirator masks serve important roles in healthcare, but they differ in levels of protection. Currently, a transparent surgical mask is available, but not an N95 version. Thus, this study aimed to evaluate the usability, fit, …

Inborn Errors Of Immunity: Manifestation, Treatment, And Outcome-An Esid Registry 1994-2024 Report On 30,628 Patients., Gerhard Kindle, Mickaël Alligon, Michael H Albert, Matthew Buckland, J David Edgar, Benjamin Gathmann, Sujal Ghosh, Antonios Gkantaras, Alexandra Nieters, Claudio Pignata, Peter N Robinson, Stephan Rusch, Catharina Schuetz, Svetlana Sharapova, Benjamin Shillitoe, Fabio Candotti, Andrew J Cant, Jean-Laurent Casanova, Amos Etzioni, Alain Fischer, Isabelle Meyts, Luigi D Notarangelo, Martine Pergent, C I Edvard Smith, Esid Registry Working Party, Lennart Hammarström, Bodo Grimbacher, Mikko R J Seppänen, Nizar Mahlaoui, Stephan Ehl, Markus G Seidel

Faculty Research 2025

The European Society for Immunodeficiencies patient registry (ESID-R), established in 1994, is one of the world's largest databases on inborn errors of immunity (IEI). IEI are genetic disorders predisposing patients to infections, autoimmunity, inflammation, allergies, and malignancies. Treatments include antimicrobial therapy, immunoglobulin replacement, immune modulation, stem cell transplantation, and gene therapy. Data from 194 centers in 33 countries capture clinical manifestations and treatments from birth onward, with annually expected updates. This report reviews the ESID-R's structure, data content, and impact. The registry includes 30,628 patient datasets (aged 0-97.9 years; median follow-up: 7.2 years; total 825,568.2 patient-years), with 13,550 cases in …

Florida Ems Voices: What Agency Providers Told Us In 2025, Michael Lozano

Florida Center for Emergency Medical Services Research Reports

The 2025 Annual Florida EMS Provider Survey provides a comprehensive overview of Florida’s EMS system, highlighting critical insights into workforce dynamics, resource allocation, medical direction, and service integration across EMS agencies statewide. Conducted from April to May 2025, the survey received robust participation from 249 agencies, covering 74.5% of licensed EMS providers. Key findings underscore regional variability in workforce recruitment, salary scales, mental health support, mobile integrated healthcare (MIH), and preparedness for mass casualty incidents.

Key areas of strategic emphasis include EMT and paramedic mental health and wellness, mobile integrated healthcare (MIH), and local quality improvement (QI) efforts. Notably, recruitment …

Icipe Monthly Digest – Volume 1, Issue 9, September 2025, International Centre Of Insect Physiology And Ecology (Icipe)

icipe Newsletters

No abstract provided.

Summer 2025, Humayun Islam

PMI Newsletter

No abstract provided.

Fisheries Occasional Publication No. 149 - Economic Contribution Of Wild-Catch Fishing In Western Australia, 2024: Beyond Gross Value Of Production, Dipesh Maharjan, Vilaphonh Xayavong, Ben Fraser, Rebecca Thomas

Fisheries Occasional Publications

The wild-catch fishing industry plays a significant role in Western Australia’s economy, particularly in regional communities. This report summarises the economic contribution of the commercial wild-catch fishing sector in 2024, based on REMPLAN’s input-output (I-O) modelling methodology and DPIRD data and analysis. This report focuses on key economic indicators including total economic output, gross value added (GVA), and employment (FTEs).

Key findings:

• Total Economic Output of the wild-catch fishing industry is $1.22 billion (total value of goods and services produced, including intermediate inputs)
• Gross Value Added (GVA) of the wild-catch fishing industry is $487 million (value of profit, wages, salaries …

Prevalence And Factors Associated With Depression, Anxiety And Post-Traumatic Stress Disorder Among Healthcare Workers From Sub-Saharan Africa: Systematic Review, Ezra Too, Peninah Wachira, Solomon Njenga, Sabina Odero, Eunice Ndirangu, Amina Abubakar

Institute for Human Development, East Africa

Background: Depression, anxiety and post-traumatic stress disorder (PTSD) are prevalent among healthcare workers (HCWs), including those from sub-Saharan Africa (SSA). However, there are limited summary data on the burden and factors associated with these disorders in this region. We conducted this systematic review (registration no. CRD42022349136) to fill this gap.

Aims: The aim of this review was to systematically summarise the available evidence on the prevalence and factors associated with depression, anxiety and PTSD, or their symptoms, among HCWs from SSA.

Method: We searched African Index Medicus, African Journals Online, CINAHL, PsycINFO and PubMed for articles published, from database inception …

Bmp Signaling Co-Regulation Of Immune Response And Lipid Metabolism, Katerina K. Yamamoto

Dissertations, Theses, and Capstone Projects

The Bone Morphogenetic Proteins (BMPs) are secreted peptide ligands of the Transforming Growth Factor beta (TGF-β) family, initially identified for their roles in development and differentiation across animal species. They are now increasingly recognized for their roles in physiology and infectious disease. In the nematode Caenorhabditis elegans, the BMP ligand DBL-1 controls fat metabolism and immune response, in addition to its roles in body size regulation and development. DBL-1 regulates classical aspects of innate immunity, including the induction of anti-microbial peptides. We theorized that BMP-dependent regulation of fat metabolism could also promote resilience against microbial pathogens. We found that …

“Lead”Ing Industrial Science: Studying Occupational Lead Poisoning In The Early 20th Century, Rebekah E. Dreyer-Rowe

Master's Theses and Capstones

Lead was essential to the creation and coalescence of industrial hygiene as a discipline in the United States from its early days in the 1910s through the 1930s when the first professional associations of industrial hygiene were formed. In the early years, Alice Hamilton was central to the burgeoning field, and her seminal study on lead poisoning in Illinois industries thrust both her and her methods into the spotlight. Industrial hygienists of her generation followed her methods and came away with similar conclusions: that occupational diseases were rampant in the US, even if few people were studying them. In the …

The Relationship Between Physical Activity And Health-Related Quality Of Life In College Students, Shelia Ann Fritts

Graduate Theses and Dissertations

This study explored the interaction effects of physical activity levels and race on college students' physical and mental health, focusing on Native American students. A total of 245 students participated, categorized by physical activity levels (low, moderate, and high) and race (Native American and others). Descriptive statistics outlined the sample characteristics and physical activity behaviors. At the same time, a two-way ANOVA was conducted to assess the effects of race and physical activity on health-related quality of life, measured through physical and mental composite scores (PCS and MCS). The results revealed a significant interaction effect between race and low physical …

No Suspicion For Nocarh: A Cautionary Tale Of Anchoring Bias, Nicole Demarco, Julia Allyson Hays, Bonnie Sullivan, Michael Price, Kimberly A. Horii, Shannon Haines

Posters

Introduction: Neonatal onset of cytopenia autoinflammation rash and hemophagocytic lymphohistiocytosis syndrome (NOCARH), a subset of hemophagocytic lymphohistiocytosis (HLH), is a rare and life-threatening condition characterized by uncontrolled immune response. It presents a diagnostic challenge in neonates due to the overlap of clinical features with other conditions, particularly congenital infections. We report a case of NOCARH in a late pre-term neonate, highlighting an atypical age group and the diagnostic difficulty of this syndrome. Case Presentation: A 1 day old ex-35 week er neonate presented to a level 4 NICU with chief complaints of pancytopenia,; an extensive petechialmaculopapular rash of on the …