Digital Commons Network^™

Factors Affecting The Quality Of Life Of Residents In The United States: Lessons From Virginia, Daniel K. Pryce

Sociology & Criminal Justice Faculty Publications

Evaluating community members' views about their quality of life is important for improving quality of well-being in society, as most societies are interested in the collective well-being of the people. Moreover, quality-of-life research helps public officials to understand how well they are meeting the needs of the electorate. Using the theoretical framework of Maslow's Developmental Perspective, which argues that the higher the need satisfaction of the majority in a given society the greater the quality of life of that society, I explore the effects of multiple variables on quality of life in the Hampton Roads region of Southeast Virginia (this …

Selective Inhibition Of Canonical Stat3 Signaling Suppresses K-Ras Mutant Lung Tumorigenesis And Reinvigorates Anti-Tumor Immunity, Michael J Clowers, Zahraa Rahal, Sung-Nam Cho, Avantika Krishna, Bo Yuan, Leticia G Hamana Zorrilla, T Kris Eckols, Moses M Kasembeli, Samuel Liu, Stephen Peng, Marco Ramos-Castaneda, Annamarie L Thompson, Carlos Ignacio Rodriguez Reyna, Katherine E Larsen, Maria T Grimaldo, Shanshan Deng, Nastaran Karimi, Cody Chou, Walter V Velasco, Melody Zarghooni, Sayan Alekseev, Luisa M Solis Soto, Edwin J Ostrin, Humam Kadara, Suhendan Ekmekcioglu, David J Tweardy, Seyed Javad Moghaddam

Faculty, Staff and Student Publications

Introduction: K-ras mutant lung adenocarcinoma (KM-LUAD) is a difficult-to-treat cancer subtype in which chronic inflammation pervades the tumor immune microenvironment (TIME). Pro-inflammatory pathways dampen the response to treatments, including immune checkpoint inhibitors, necessitating therapies that target this inflammatory signaling network in the TIME. One of the lynchpins of chronic inflammation in KM-LUAD is signal transducer and activator of transcription 3 (STAT3).

Methods: Here, we tested the anti-tumor and early immunotherapeutic efficacy of TTI-101, a selective small-molecule inhibitor of canonical STAT3 signaling, in a K-rasG12D mutant lung cancer mouse model (CC-LR).

Results: Treatment of CC-LR mice with TTI-101 resulted in reduced …

A Study Of Regulatory Compliance In U.S. Nursing Homes, Patrick Schumacher

Electronic Theses & Dissertations (2024 - present)

The federal government is responsible for ensuring that nursing homes comply with regulations designed to protect residents from abuse, neglect, and substandard care. To this end, the Centers for Medicare and Medicaid Services (CMS) partners with states to conduct onsite inspections of nursing homes, during which regulators may identify violations. The agency can take one or more actions in response to violations, including imposing civil money penalties (fines), appointing a state monitor, or mandating remedial education for staff. Despite this regulatory framework, the quality of care in nursing homes remains poor, with many facilities failing to protect the well-being of …

Queer Coasts: Beach Space, Climate Change, And The American Queer Community, Erin Cardoza

Open Access Master's Theses

Queer coastal spaces and beaches have been culturally and historically significant to the LGBTQ+ community for decades. These sites provide visibility, acceptance, and community allowing for LGBTQ+ folks to connect, organize, and find refuge from societal stigma and discrimination. However, these spaces face increasing threats from climate change, gentrification and privatization, and shifting societal dynamics. This research was conducted at two historically queer beaches on the American East Coast, Herring Cove in Provincetown, Massachusetts, and Jacob Riis Park in Queens, New York. This study examined the similarities and differences between these sites regarding (1) the importance of beach spaces for …

Fixation On Viruses: Eye-Tracking, Image-Based Agency, And Fear-Appeal Desensitization, Braden Bagley, Lijie Zhou, Hayden Coombs, Matthew Barton

Iowa Journal of Communication

This study examined the effects of image-based assignment of agency (IAA) on COVID-19 and flu fear-appeals by employing eye-tracking technology. Volunteers participated in a 2x2x2 between-groups experiment. Fixation-count and fixation-duration were collected by a Tobii Pro X3-120 Screen-Based Eye-Tracker. After reviewing a fact sheet, participants answered a 29-item survey that included items aligning with the extended parallel process model. The flu/agentic-image/virus-agentic-language message produced significantly higher fixation-frequency to the image and a higher perception of severity than the COVID-19/real-image/human-agentic-language message. Fixation-frequency on the image produced significantly higher fear perceptions, but significantly lower message-quality and message-credibility perceptions. Flu messages led to significantly …

Engineering Extracellular Vesicles (Evs) To Combat Infection And Inflammation In Cystic Fibrosis, Sharanya Sarkar

Dartmouth College Ph.D Dissertations

Cystic Fibrosis (CF) is a multisystemic genetic disorder caused by mutations in the CFTR gene, resulting in chronic pulmonary infections, hyperinflammation, and progressive lung damage. Among the pathogens that colonize CF lungs, Pseudomonas aeruginosa (P. aeruginosa) is predominant, infecting over 50% of adults with CF and developing antibiotic resistance over time. Current modulator therapies fail to address persistent bacterial infections, chronic inflammation, or irreversible lung damage, underscoring the need for novel therapeutic strategies. In our previous in vitro studies, we demonstrated that extracellular vesicles (EVs) secreted by primary Human Bronchial Epithelial Cells (HBECs) inhibit P. aeruginosa growth by reducing the …

In Pursuit Of Sovereignty: Transformations Of Colonial Medicine From Wilhelmine To Nazi Germany, Veda Joshi

All ETDs from UAB

After the Berlin Conference of 1884-1885, the Great Powers of Europe, including the newly-born German Empire, greatly expanded their influence and colonial possessions in Africa, with colonies in East Asia and the South Pacific quickly following suit. The German Empire, like its contemporaries, engaged with medicine as a necessary part of its colonial endeavors in order to keep both its native laborers and European settlers healthy. Using documents from the German Bundesarchiv (Federal Archive), including official reports made to the German Colonial Office and documenting of formally conducted expeditions, as well as the writings of colonial doctors, this research examines …

Evaluation Of In Vitro Cardiac Models For Characterizing The Role Of Autophagy In Streptococcus Pneumoniae Infection, Georgianna Khong

All ETDs from UAB

Streptococcus pneumoniae (Spn) is a gram-positive bacterium that causes community-acquired pneumonia, the most prevalent type of pneumonia and a predominant infectious disease. There is evidence linking Spn infection to cardiovascular damage through the ability of Spn to invade and replicate in the myocardium, inducing cardiomyocyte death and disrupting cardiac function. Spn infects cardiomyocytes intracellularly through clathrin-mediated endocytosis, with demonstrated evidence of inhibitory mechanisms including clathrin-mediated endocytosis inhibitors and antioxidants. As a result, autophagy is being investigated as a potential pathway for cardiomyocyte self-defense against Spn, as it may protect cardiomyocytes intracellularly. The primary objective of this study was to evaluate …

Endothelial Cell Cd36 In Alzheimer’S Disease And Breast Cancer Progression, Atul Kumar

All ETDs from UAB

Vascular endothelial cells (ECs) are increasingly recognized as a distinct class of innate immune cells, with CD36, an innate immunity receptor, playing a pivotal role in regulating immune function and its regulation, angiogenesis, cancer progression, brain related disorder as well as the exchange of nutrients and waste. To investigate this further, we developed EC-specific CD36 knockout mice using the translating ribosome affinity purification (TRAP) technique. By isolating ribosome-bound mRNA directly from vascular endothelial cells in vivo in these knockout and control mice, we conducted deep RNA sequencing and transcriptional profiling. Our findings revealed that CD36 deficiency in brain endothelia led …

Maternal Immune Activation Causes Oligodendrocyte Deficits In The Hypothalamus, Kate Miller

All ETDs from UAB

Maternal immune activation (MIA) refers to the occurrence of an inflammatory immune response during any stage of pregnancy. This manifests as the upregulation of proinflammatory cytokines and can be caused by air pollution, obesity, or viral infection. When this occurs during the first trimester in humans, it increases the offspring’s susceptibility to developing neuropsychiatric disorders such as autism (ASD) and schizophrenia (SZ), in males more commonly than females. In addition to behavioral manifestations of neuropsychiatric disorders, metabolic syndrome (MetS) is a common comorbidity, defined as the co-occurrence of three or more symptoms including but not limited to hyperlipidemia, hypertension, and …

Investigating Risk Of Suboptimal Hiv Treatment Outcomes (Treatment Failure And Disengagement) Among Pregnant And Postpartum Women Living With Hiv, Kevin Owuor

All ETDs from UAB

The joint United Nations Programme on HIV/AIDS (UNAIDS) has set targets to end the HIV epidemic by improving HIV diagnosis, treatment, and viral suppression to reduce new infections and improve health outcomes for people living with HIV (PLHIV), including pregnant and postpartum women living with HIV (PPWH). After diagnosis, linking PPWH to antiretroviral (ART) treatment is critical to suppress the virus and prevent mother-to-child transmission (MTCT) of HIV. Continuous engagement in care is essential for achieving and maintaining virologic suppression in the peripartum and postpartum period for PPWH, both for their own health and the health of their family. Disengagement …

Clarification Of Public Health Pathways Toward Clinical Careers: A Pilot Study Describing A Benchmark Analysis Project, Elizabeth A. Brown, Melissa Feliciano, Daniel Martinez

Health Behavior, Policy & Management Faculty Publications

Introduction: Undergraduate public health programs have adapted the required basic sciences based on medical and technological advances and the needs of the public health workforce. We aim to demonstrate how a benchmark analysis project was used to improve curriculum and develop a model where basic sciences in public health can be used to build pathways to clinical graduate programs like medicine, pharmacy, physician assistant, etc.

Methods: Authors conducted a benchmark analysis of Bachelor of Science in Public Health (BSPH) Degrees (or public health-related degrees) in the southern region of the United States (US) to explore required basic sciences. Authors searched …

Trust During Troubled Times: Evidence From Sierra Leone’S Ebola Epidemic, Colin Cannonier

Funded Scholarship

Existing literature provides evidence that crises can considerably impact public trust. However, research on these dynamics in lower-income and postconflict countries like Sierra Leone is limited. Using nationally representative survey data and district-level Ebola infection data, herein, we examine the relationship between the Ebola epidemic and various measures of government trust. Our analysis, which employs propensity score matching and other techniques, reveals a notable decline in trust among individuals exposed to the outbreak. Our estimates indicate that individual perceptions of trust in government and other government entities decreased by 11.6%– 33.6% following the Ebola epidemic. This relationship is driven by …

Genomic Epidemiology Of Staphylococcus Aureus Sequence-Type 97, Eva Armao

Honors Undergraduate Theses

Staphylococcus aureus (S. aureus) is a gram-positive bacterial pathogen that colonizes human nasal passages, mucous membranes, or the skin of carriers, with colonization commonly found in 20-30% of healthy people. S. aureus has the potential for two types of infection within human hosts: methicillin-susceptible (MSSA) and methicillin-resistant (MRSA). These infections can be further classified based on their route of infection, either known as community-associated (CA), healthcare-associated (HA), or healthcare-associated community-onset (HACO). Upon further investigation of infected populations, specific genetic subtypes of S. aureus, known as sequence types (ST), have been identified globally, with some exhibiting increased virulence among …

Readmission Reduction Of 1st Year Transplant Recipients, Kristin Freed

Yale School of Nursing Digital Theses

Abstract Readmission Reduction of 1st Year Transplant Recipients Clear communication with patients at their health-literacy level improves patient outcomes, fosters trust, and is associated with readmission reduction. Readmission of transplant recipients are correlated with morbidity, medical errors, higher healthcare economic costs, and indicative of decreased survival post- transplant. Literature suggests that up to 72% of transplant recipients may have low health literacy increasing risk of readmission. The Agency of Healthcare Research and Quality created the REALM-SF assessment as a tool for medical providers to evaluate a patient’s health literacy status in a timely manner. This Doctor of Nursing Practice (DNP) …

State Of The University Annual Report - 2024-2025, Office Of The President, East Tennessee State University, University Marketing And Communication, East Tennessee State University

Office of the President State of the University Annual Report

No abstract provided.

University Of Minnesota Morris Catalog 2025-2027, University Of Minnesota-Morris

UMM Catalog

This document serves as an official historical record for a specific period in time. The information found is subject to change without notice. Colleges and departments make changes to their degree requirements and course descriptions frequently. More information is available at catalogs.umn.edu.

Human Trafficking In The Er: Will You Recognize The Signs?, Lauren Neff

Doctor of Nursing Practice Projects

Current data reveals that 88% of human trafficking (HT) victims seek some form of health care while being trafficked. More specifically, 63% seek care in the emergency department setting (McAmis et al., 2022). A recent literature review indicates that regarding human trafficking and healthcare, there is a lack of awareness and knowledge on the issue. Healthcare team members often have little to no education or knowledge of potential signs and symptoms of a victim in a trafficking situation. The purpose of this DNP project was to increase healthcare staff knowledge of human trafficking (HT) and, more specifically, nurses in an …

Educational Sessions On Opioid Use Disorder In A Rural Community: A Faith-Based Approach, Tarrelle Reade

Doctor of Nursing Practice Projects

This scholarly project aimed to evaluate the effectiveness of a faith-based community education program regarding opioid use disorder (OUD) in a rural area of Person County, North Carolina. Through 4 weekly sessions hosted at Lattisville Grove Missionary Baptist Church, the program provided education on the signs and symptoms of opioid misuse, associated risks, available treatment options, support resources, and the use of Narcan. A pre- and post-survey design using a Likert scale measured changes in knowledge and confidence across five key domains. Data from participants (n = 54 total) showed statistically significant improvements in awareness and self-efficacy in most areas, …

Rare Case Of Osteomyelitis Caused By Achromobacter Xylosoxidans, Christopher P. Girgis, Tyler L. Coye, Elizabeth Ansert, Amanda L. Killeen, Peter A. Crisologo

School of Podiatric Medicine Publications

Achromobacter xylosoxidans is a rare opportunistic aerobe that has rarely been documented in the literature as a causative agent for osteomyelitis. It can present with antibiotic resistance, making treatment without operative management challenging. We present the case of a 51-year-old male with a past medical history of uncontrolled type 2 diabetes. The patient presented to a clinic with a grade 2 infection to the right fifth digit, as defined by the International Working Group on the Diabetic Foot, and was subsequently admitted for intravenous antibiotics and operative management. Magnetic resonance imaging revealed abnormal signal of the phalanges of the fifth …

Concordance Of Molecular Microbiology And Conventional Culture Techniques For Infected Diabetic Foot Ulcer Management, Angela Oates, Sarah T. Brown, Colin C. Everett, Fran Game, Jane E. Nixon, Tim Sloan, Michelle M. Lister, Michael Backhouse, Benjamin A. Lipsky, David Russell, Howard Collier, Joanna Dennett, Rachael Gilberts, E. Andrea Nelson, Jon Deeks, Sue Mallett, Roger Gasdby, Jane Lewis, Julie Brittenden, Andrew Bradbury, Joanne Paton, Zoe Hoare, Deborah Fitzsimmons, Mark Wilcox, Gerry Rayman, Brenda Riley, Christine Thomas, Ravikanth Gouni, Haroon Siddique, Gillian A. Lomax

School of Health Professions

Aim: The management of infected diabetic foot ulcers (DFUs) requires balancing the need for timely interventions against the desire for targeted antibiotic therapy, which relies on laboratory results. This study aimed to evaluate concordance between molecular and conventional culture and sensitivity (C&S) methods in identifying bacteria from infected DFUs. Methods: This study was conducted alongside CODIFI2, a Phase III randomised controlled trial comparing tissue sampling with wound swabbing. It assessed C&S and metagenomic 16S rRNA gene sequencing (M16S) in DFUs with suspected mild or moderate infections using both tissue and swab samples. Results: In 145 participants, C&S identified 248 microorganisms …

The Path To Zero Clabsis: The Benefits Of Central Line Care Teams, Supplemental Checklist, Increased Education And Utilizing Clabsi Bundles, Lauren A. Bondurant

Doctor of Nursing Practice Projects

Central line-associated bloodstream infections (CLABSIs) result in a plethora of deaths each year and cost the U.S. healthcare system billions of dollars (Centers for Disease Control and Prevention, 2024). CLABSIs have been a type of bloodstream infection that has affected a plethora of individuals for years and one that does not discriminate patient type. Many articles were reviewed, but they all inferred that CLABSIs bundles,supplemental checklists, and central line care teams all showed the most significant data and resulted in the most decreased CLABSI rates. Upon assessment of the project unit, it was noted that the issue that most impacted …

Beyond Genes: Non-Canonical Mechanisms Driving Antimicrobial Resistance In Bacteria, Leonard Koolman, Chijioke Emenike, Debasis Mitra, Sourav Chattaraj

Research Outputs: 2025-Present

Antimicrobial resistance (AMR) is traditionally discussed in the context of horizontally acquired resistance genes and point mutations at target loci. However, this gene-centred model fails to account for a large number of clinically important modalities of resistance. There is now substantial evidence implicating bacteria in the ability to escape the effects of antibiotics in a variety of non-canonical ways, which are not considered in traditional diagnostic and surveillance pipelines. Among these factors, we can list those arising from global regulatory networks, phase variability, epigenetic tuning, small RNAs, genome structural variability, and phenotypic states like tolerance and persistence. This review will …

Directing Patient Hand Hygiene Before Meals In The Icu: A Quality Improvement Project To Enhance Patient Safety, Nicholas Davini

Master's Theses and Capstones

BACKGROUND:

Hospital-acquired infections (HAIs) are a major problem in healthcare, increasing patient morbidity, mortality, and costs. While staff hand hygiene is a well-established infection control measure, less attention is paid to patient hand hygiene (PHH) despite CDC recommendations.

LOCAL PROBLEM:

An intensive care unit (ICU) in northeastern Massachusetts had no formal policy for patient hand hygiene, and hospital leadership expressed support for enhancing infection control practices.

METHODS:

Using the Plan-Do-Study-Act model, a quality improvement project was implemented to encourage PHH before meals. Baseline PHH rates were collected through observation. The intervention involved registered nurses (RNs) directing patients to use hand …

Evaluation Of Bacterial Contamination On Flush Levers And Faucet Tap Handles In The Institute Of Biological Sciences Building Restrooms, University Of The Philippines Los Baños, Jan Patricia S. Estillore, Ronilo Jose D. Flores, Renard M. Jamora

Journal Article

Public restrooms provide convenience outside the home but are frequented by many users daily, creating a risk of microbial contamination on commonly touched surfaces such as flush levers and faucet handles. This study assessed microbial loads on these surfaces across genders and floors and aimed to isolate antibiotic-resistant Staphylococcus species and characterize Enterobacteriaceae. Samples were collected from flush levers and faucet handles across three floors of Wing C, Institute of Biological Sciences, University of the Philippines Los Baños, Laguna, Philippines. Results showed that faucet handles (7.9 × 109CFU/cm2) harbored higher microbial loads than flush levers (5.3 × 109CFU/cm2), and female …

Profile And Characteristic Dental Anomalies And Oral Hygiene Status In Down Syndrome Children, Nurlindah Hamrun, Ameta Primasari, Elza Ibrahim, Asmawati Amin, Syakriani Syahrir, Fadhlil Ua. Rahman, Aprivita Lt. Padang, Aziza D. Risqillah

Journal of Dentomaxillofacial Science

No abstract provided.

The Potential Of Oral Cavity Bacterial Relative Abundance Index For Determining The Severity Of Dental Caries, Masyhudi, Krishna P. Candra, Esti H. Hardi, Aman S. Panggabean, Islamuddin Ahmad, Hadi Kuncoro, Rudy A. Nugroho

Journal of Dentomaxillofacial Science

No abstract provided.

Electrochemical Strategies For Microrna Quantification Leveraging Amplification And Nanomaterials: A Review, Alexander Hunt, Gymama Slaughter

Center for Bioelectronics Publications

MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression and have emerged as critical biomarkers in various diseases, including cancer. Their stability in bodily fluids and role as oncogenes or tumor suppressors make them attractive targets for non-invasive diagnostics. However, conventional detection methods, such as Northern blotting, RT-PCR, and microarrays, are limited by low sensitivity, lengthy protocols, and limited specificity. Electrochemical biosensors offer a promising alternative, providing high sensitivity, rapid response times, portability, and cost-effectiveness. These biosensors translate miRNA hybridization events into quantifiable electrochemical signals, often leveraging redox-active labels, mediators, or intercalators. Recent advancements in nanomaterials and signal amplification …

Responses To Tobacco Use Screening And Tobacco Cessation Assistance Offers Among Rural And Ubran Cancer Survivors At An Nci-Designated Comprehensive Cancer, Abigayle Feather

Theses and Dissertations--Psychology

Smoking after cancer diagnosis is associated with poor outcomes while smoking cessation can improve quality of life and promote survival. Although there are calls for equitable tobacco treatment delivery in cancer and other healthcare settings, disparities in tobacco-related disease burden persist. In the context of an outpatient cancer center’s population-based tobacco treatment program, this study examines the association between cancer survivors’ rural and Appalachian residence and 1) current tobacco use status, 2) decision to decline cessation assistance, and 3) reason for declining assistance. A cross-sectional, retrospective analysis was conducted using electronic health record data from 16,839 adults (64.04% female, 88.49% …

The Effects Of Plx 3397 On Fentanyl Escalation In Male And Female Sprague-Dawley Rats, Jakob Shaykin

Theses and Dissertations--Psychology

Purpose: A hallmark characteristic of opioid use disorder (OUD) is a persons’ ‘loss of control’, which leads to the compulsion to seek and obtain opioids, resulting in increased consumption. This phenomenon is known as ‘escalation of drug intake’. Chronic opioid use causes microglial reactivity and subsequent release of proinflammatory cytokines leading to neuroinflammation, weakening one’s executive control over drug taking and ultimately leading to greater use. Previous research in our laboratory has explored heterogeneity of fentanyl intake in extended access (6-hr) sessions and identified distinct endophenotypes of fentanyl intake. Moreover, we have observed a positive correlation between Treml1 expression …