Digital Commons Network^™

Mycetohabitans Rhizoxinica Bacteremia In The Setting Of Invasive Fungal Disease In An Immunocompromised Patient, Marisa Orbea, Mary Fortini, Megan H Amerson-Brown, Debra L Palazzi, James J Dunn

Faculty, Staff and Students Publications

Background: Mycetohabitans [Burkholderia] rhizoxinica is an endosymbiotic bacteria of Rhizopus microsporus that normally causes rice seedling blight. In our case report, we present one of the first known cases of concomitant bacteremia with M. rhizoxinica and invasive mold infection due to Rhizopus spp. in an immunocompromised child.

Case summary: A 3 year old male recently diagnosed with B-cell acute lymphoblastic leukemia developed febrile neutropenia. His workup was significant for invasive fungal sinusitis due to Exserohilum spp. based on histopathology and culture, a right middle lobe infiltrate, and a blood culture positive for gram-negative coccobacilli, later identified as M. …

Performance Of Stool Xpert Mtb/Rif Ultra For Detection Of Mycobacterium Tuberculosis Among Adults Living With Hiv: A Multicentre, Prospective Diagnostic Study, George W Kasule, Sabine Hermans, Sozinho Acacio, Alexander Kay, Joachim Kikoyo Nsubuga, Carlos Fernández-Escobar, Nosisa Shiba, Lucia Carratalá-Castro, Derrick Semugenze, Patricia Mwachan, Shilzia Munguambe, Joanna Ehrlich, Elisa Lopez-Varela, Andrew R Dinardo, Frank Cobelens, Christoph Lange, Moses Joloba, Anna M Mandalakas, Willy Ssengooba, Alberto L García-Basteiro

Faculty, Staff and Students Publications

Background: When people living with HIV develop pulmonary tuberculosis, it often manifests without detectable acid-fast bacilli on sputum microscopy. We aimed to assess the diagnostic accuracy of stool Xpert MTB/RIF Ultra (hereafter, Ultra) for Mycobacterium tuberculosis detection among adults with HIV.

Methods: This multicentre, prospective diagnostic accuracy study was done in outpatient and inpatient health centres in Eswatini, Mozambique, and Uganda. We enrolled adults aged 15 years and older with HIV with presumptive tuberculosis. We evaluated the diagnostic accuracy of stool Ultra using the simple one-step processing method against a composite microbiological reference standard (CMRS) including three WHO-recommended tuberculosis diagnostic …

Short-Term Neurologic Outcomes In Pediatric Extracorporeal Membrane Oxygenation Are Proportional To Bleeding Severity Graded By A Novel Bleeding Scale, Katherine Doane, Danielle Guffey, Laura L Loftis, Trung C Nguyen, Matthew A Musick, Amanda Ruth, Ryan D Coleman, Jun Teruya, Christine Allen, Melania M Bembea, Brian Boville, Jamie Furlong-Dillard, Santosh Kaipa, Mara Leimanis, Matthew P Malone, Lindsey K Rasmussen, Ahmed Said, Marie E Steiner, Deanna T Tzanetos, Heather Viamonte, Linda Wallenkamp, Arun Saini

Faculty, Staff and Students Publications

Patients admitted to a pediatric intensive care unit (PICU) need individualized nutrition support that is tailored to their particular disease severity, nutritional status, and therapeutic interventions. We aim to evaluate how calories and proteins are provided during the first seven days of hospitalization for children in critical condition with organ dysfunction (OD). A single-center retrospective cohort study of children aged 2–18 years, mechanically ventilated > 48 h, and admitted > 7 days to a PICU from 2016 to 2017 was carried out. Nutrition support included enteral and parenteral nutrition. We calculated scores for the Pediatric Sequential Organ Failure Assessment (pSOFA) on days …

Integrating Nonindividual Patient Features In Machine Learning Models Of Hospital-Onset Bacteremia, M Cristina Vazquez-Guillamet, Jingwen Zhang, Alice Bewley, Andrew Atkinson, Heidi Holtz, Ziqian Wang, Nicole Brougham, Chenyang Lu, Marin H Kollef, Philip Payne, David Warren, Victoria J Fraser

2020-Current year OA Pubs

IMPORTANCE: Hospital-onset bacteremia and fungemia (HOB) are common and potentially preventable complications of hospital care.

OBJECTIVE: To assess whether nonindividual patient features, which summarize interactions with other patients and health care workers (HCWs), can contribute to predictive and causal machine learning models for HOB.

DESIGN, SETTING, AND PARTICIPANTS: This prognostic study included adult patients admitted to Barnes-Jewish Hospital, an academic hospital in St Louis, Missouri, in 2021. Analyses were developed between October 2023 and August 2024 and in April 2025.

EXPOSURE: Individual patient features were extracted from electronic health records and used to engineer nonpatient features, including interactions with HCWs …

Utility Of The Us Preventive Services Task Force For Preeclampsia Risk Assessment And Aspirin Prophylaxis, Thomas F Mcelrath, Antonina I Frolova, Et Al.

2020-Current year OA Pubs

IMPORTANCE: The US Preventive Services Task Force (USPSTF) guidelines on preeclampsia risk assessment and aspirin prophylaxis (AP) have not been evaluated for clinical utility.

OBJECTIVE: To evaluate which characteristics in the USPSTF guidelines identify risk status and the association of preeclampsia risk with AP recommendations.

DESIGN, SETTING, AND PARTICIPANTS: This observational cohort study enrolled from July 2020 to March 2023 with data analysis performed from October to December 2024. Enrollment occurred at 11 centers throughout the US or via direct-to-participant recruitment. Pregnant participants aged 18 years or older with a singleton pregnancy less than 22 weeks' gestation were selected via …

Covid-19-Associated Pulmonary Aspergillosis In Mechanically Ventilated Patients At 7 Us Hospitals: Epidemiology And Estimated Likelihood Of Invasive Pulmonary Aspergillosis-Results Of The Prospective Msg-017 Study, M Hong Nguyen, Sixto M Leal, Luis Ostrosky-Zeichner, Andrej Spec, George R Thompson, Thomas F Patterson, John Baddley, Rachel Mcmullen, Drashti Shah, Cornelius J Clancy, Gerald Mcgwin, Peter G Pappas

2020-Current year OA Pubs

BACKGROUND: There is no prospective, US multicenter study of COVID-19-associated pulmonary aspergillosis (CAPA). CAPA definitions do not differentiate invasive aspergillosis (IPA) from colonization. Validity of single mycologic test results is unclear.

METHODS: We performed a prospective 7-center US study of mechanically ventilated adults with COVID-19 (April 2021-May 2022). Mycoses Study Group (MSGERC) CAPA criteria include host and clinical factors, imaging and test results (histopathology; bronchoalveolar lavage [BAL] culture and/or BAL or serum galactomannan-immunoassay). Proven, putative, and unlikely IPA were defined by clinical criteria. CAPA-unlikely IPA criteria included survival or negative autopsy following no/limited antifungal treatment. IPA likelihood was estimated using …

Liger-Hn Phase Iii Trials Of Petosemtamab + Pembrolizumab And Petosemtamab Monotherapy In Recurrent Or Metastatic Hnscc, Jean-Pascal Machiels, Douglas Adkins, Et Al.

2020-Current year OA Pubs

Patients with recurrent/metastatic (r/m) head and neck squamous cell carcinoma (HNSCC) have limited treatment options and a dismal prognosis, especially when their cancer is resistant to standard treatments like anti-programmed cell death protein 1 and platinum-based therapies. Petosemtamab - a human, common light chain, bispecific antibody with enhanced antibody-dependent cellular cytotoxicity targeting epidermal growth factor receptor (EGFR) and leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) - demonstrated antitumor activity in r/m HNSCC. In many tumor types, including HNSCC, EGFR is an oncogenic driver, while LGR5 is upregulated. LGR5 can potentiate the wingless-type integration site (WNT)/β-catenin signaling pathway in response to …

Clinical Evaluation Of The Healgen Rapid Covid-19 Antigen Test As A Point-Of-Care Diagnostic Tool, Stephen A Young, Hua Zhang, Jose Rodriguez, David Mishkin, Ward Paine, Li Seyfried, Latisha Hargrove, Dennis L Broyles, Chermaen Lindberg, Anurag Purushothaman, Stacey House

2020-Current year OA Pubs

BACKGROUND: Development of readily available Rapid COVID-19 Antigen tests essential for promptly identifying SARS-CoV2 infection and preventing its spread.

METHODS: This study evaluated the clinical performance of the Healgen Rapid COVID-19 antigen test as a point-of-care diagnostic tool with 806 evaluable subjects who were within 6 days post-symptom onset. The results from the Healgen test were compared to the results from Emergency Use Authorization (EUA) approved SARS-CoV-2 RT-PCR tests.

RESULTS: Out of the 806 evaluable subjects, 140 tested positive and 640 tested negative for SARS-CoV-2 with the Healgen COVID-19 test, showing good agreement with the EUA RT-PCR results. There were …

Technical Quality Of Cta Chest Pulmonary Embolism Protocol: Can We Do Better?, Sai Mandava

Graduate Medical Education Research Journal

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Presentation And Management Of Pinch-Off Syndrome: A Rare Complication Of Subclavian Venous Catheters, Neal Kucera

Graduate Medical Education Research Journal

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Giant Cell Myocarditis In The Setting Of Ischemic Cardiomyopathy, Chukwuebuka Ubochi

Graduate Medical Education Research Journal

NA

Midtown Clinic Buprenorphine Quality Improvement Project, Andrew Regoli

Graduate Medical Education Research Journal

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4 Weeks Of Dyspnea In Immunocompromised Woman: Presenting Symptom Of Disseminated Histoplasma Capsulatum, Cristina Torres

Graduate Medical Education Research Journal

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Percutaneous Transhepatic Cholangioscopy: New Horizons For Challenging Biliary Interventions, Jeremy Stone

Graduate Medical Education Research Journal

NA

Long-Term Autoimmune Polyarthritis Due To Covid-19 Vaccine, Ramesh Pandit, Namratha Pallipamu, Trupiti Pandit

HCA Healthcare Journal of Medicine

Background

Vaccinations for COVID-19 have played a pivotal role in controlling the global pandemic, with most adverse events being mild and transient. However, rare post-vaccination autoimmune responses have been reported. The understanding of long-term rheumatologic sequelae, particularly autoimmune polyarthritis following COVID-19 vaccination, remains limited.

Case Presentation

We report the case of a 41-year-old previously healthy man who developed progressive polyarthritis and systemic symptoms following the Johnson & Johnson COVID-19 vaccine. The initial symptoms of joint swelling and arthralgia appeared within a week of the first vaccine dose, subsiding temporarily with medication. After receiving a booster dose, the patient experienced worsening …

Covid-19 Vaccine-Induced Rhabdomyolysis In A 53-Year-Old Woman, Akash Hazari, Jack Chien, Daniel Nunez

HCA Healthcare Journal of Medicine

Introduction

COVID-19-induced rhabdomyolysis is a common complication in COVID-19 infection. However, only a handful of cases have been reported showing links between COVID-19 vaccine and rhabdomyolysis.

Case Presentation

We present the case of a 53-year-old woman, who recently received COVID-19 vaccine and presented to the hospital with progressive extremity weakness. Common reasons for rhabdomyolysis were ruled out as possibility and the patient was found to have rhabdomyolysis induced from COVID-19 vaccine.

Conclusion

Even though COVID-19 vaccine-induced rhabdomyolysis is rare, it should be considered in the differential diagnosis with patients presenting with neuromuscular complaints and a recent COVID-19 vaccine.

Efficacy And Safety Of Lotilaner Ophthalmic Solution 0.25% In Demodex Blepharitis: A Systematic Review, Stephanie P. Fabara, Thalia Fabara, Akankcha Alok, Nausheen Khuddus

HCA Healthcare Journal of Medicine

Demodex blepharitis is a chronic eyelid inflammation caused by Demodex mites, which are ubiquitous skin parasites. Lotilaner, a newly United States Food and Drug Administration (FDA)-approved drug, is an antiparasitic agent that selectively inhibits parasite-specific γ-aminobutyric acid chloride channels, inducing spastic paralysis and death of Demodex mites. It is applied as an ophthalmic solution, 0.25%, twice a day for 6 weeks, and it has a long half-life and high lipophilicity, facilitating the penetration of the drug into the eyelash follicles and meibomian glands where the mites reside. This study systematically reviewed 6 clinical trials that compared lotilaner with placebo for …

Are Digital And Social Media Marketing Matters For Tajikistan’S Youth Travelers?, Namozov Jamshed, Gita Gayatri

ASEAN Marketing Journal

This research examines the influence of social media and online marketing on the travel behaviours of youth -domestic - tourists in a capital city of Tajikistan, Dushanbe, as the main destination. With the development of new technologies in the modern digital age, digital tools could significantly change the preferences of travellers to choose tourism destinations. In this regard, social media, with its wide audience through Instagram, Facebook, YouTube, and others, became not only an effective tool for tourism marketing but also for affecting tourism decision-making processes. That's why the study examines the impact of tourists’ attitudes towards online tourism information, …

Gejala Neuropsikiatri Pasien Hiv Setelah Menjalani Transisi Antiretrovirus Nevirapin Ke Dolutegravir Di Rumah Sakit Cipto Mangunkusumo, Jakarta, Metra Adi Pratama, Rudi Putranto, Herqutanto Herqutanto, Aisyah Syahrani, Aljira Fitya Hapsari, Veritea Natali, Meivina Ramadhani Pane, Evy Yunihastuti

Jurnal Penyakit Dalam Indonesia

Introduction. Dolutegravir (DTG) is one of the effective antiretroviral therapies (ART) for suppressing HIV replication and has a favorable safety profile. However, reports regarding neuropsychiatric side effects, especially in patients transitioning from a nevirapine (NVP) regimen to dolutegravir, have started to emerge. This study aimed to describe the changes in neuropsychiatric symptoms before and after the transition from a NVP-based ARV regimen to DTG in HIV patients at Cipto Mangunkusumo Hospital (RSCM), Jakarta.

Methods. This study employed a prospective cohort design involving 292 HIV patients at Cipto Mangunkusumo Hospital who were transitioning from NVP to DTG regimen. Participants …

Spatially Resolved Transcriptomic Profiles Of Placental Cell Populations In Placental Malaria, Corina A. Mong

Undergraduate Honors Theses

Malaria remains a prevalent infectious disease that continues to cause disease-related morbidity and mortality. Despite preventative efforts, malarial pregnancies still cause birth complications, therefore emphasizing the necessity to study these adverse outcomes in malarial pregnancy. Malaria in pregnancy can lead to placental malaria (PM), which is the presence and accumulation of Plasmodium-infected red blood cells in the placental intervillous space (IVS). Even after treatment, past PM (presence of hemozoin crystals from the parasite in the placenta) can cause a chronic inflammatory response. We predicted that the activation states of the maternal monocytes and fetal macrophages differ within the placenta and …

Distribusi Kejadian Diare Pada Balita Dan Kualitas Sumber Air Minum Di Indonesia: Studi Ekologi, Nadia Z. Sabira, Naijla I. Shaliha, Sandrina H. Salsabila, Wellsa D. Kusumaningrum

Jurnal Nasional Kesehatan Lingkungan Global

Background: Diarrhea is an infectious disease with the third highest mortality rate in children under 5 years of age globally. The Indonesian Ministry of Health states that 88% of deaths from diarrhea in children are caused by poor sanitation practices and inadequate quality of drinking water sources. This study aims to describe the distribution of the quality of drinking water sources and the prevalence of diarrhea in all provinces in Indonesia. Methods: This study used an ecological study approach with secondary aggregate data from Survei Kesehatan Indonesia (SKI) 2023 and Studi Kualitas Air Minum Rumah Tangga (SKAM RT) 2020. The …

Determinants Of Catastrophic Health Expenditure Of Households In Indonesia, Rafa Fayza Afrizal, Novira Hasya, Faticha Putri Harda, Wildan Avif Alfathin, Vanissa Nur Latifah, Maxent Rael Nainggolan, Fadillah Rahmah Jaelani, Estro Dariatno Sihaloho

Jurnal Ekonomi Kesehatan Indonesia

The need for healthcare services due to illness is unpredictable, thus burdening patients economically and posing a risk of catastrophic events. The percentage of households with catastrophic health expenditures is defined as out-of-pocket payments exceeding 10% of the household’s capacity to pay for healthcare. Increasing catastrophic expenditure costs can further deteriorate the household’s financial condition. This study analyzes the determinants of catastrophic health expenditures in Indonesian households. A total of 12,892 household samples from the cross-sectional Indonesian Family Life Survey (IFLS) wave 5 (2014) were used in this study. Using a logistic regression model, this study aims to identify various …

Demographic Characteristics And History Of Pulmonary Tb Treatment In Malang City In 2022-2023, Ema Novita Deniati, Zalva Hanny Fauzia, St. Mutrifatul Imthiatiyyah, Muhammad Thoriq Haidar Rantaka

Preventia: The Indonesian Journal of Public Health

Tuberculosis (TB) is currently in thirteenth place as the main cause of death globally. In 2022, at East Java there were 78,799 cases of pulmonary TB. The success rate for TB treatment in East Java is 89.01 percent or has not yet reached the target for the Treatment Success Rate indicator in 2022, which is 90 percent. Meanwhile in Malang City, in 2022 there were 2,417 TB cases and this will increase in 2023 to 2,716 cases. The increase in cases occurs because people still think it's trivial, especially when they cough and are reluctant to get checked, but when …

Diarrhea Risk Factors Of Toddlers In Jember District, 2022, Annisa Fitrah Aini, Yunus Ariyanto, Adistha Eka Noveyani

Preventia: The Indonesian Journal of Public Health

Diarrhea is a disease characterized by passing feces three or more times a day. The occurrence of diarrhea is also influenced by sociodemographic factors (nutritional status) and environmental factors (access to clean water, access to sanitary latrines, and living in flood-prone areas). The purpose of this research focuses on finding risk factors for diarrhea and mapping the risk factors of diarrhea. This study used an ecological study design, in which the population is all sub-districts in Jember. Secondary data were used in this research. The data were analyzed using statistical correlation analysis using SPSS and mapping using GIS software. The …

Investigation Of Some Biochemical Parameters Changes Due To Coronavirus Infections, Lamiaa Al-Maliki, Manaf A. Guma, Mustafa A. J. Alhiti, Shahad M. Ali, Salman Ashraf, Abdel-Raheem M. A.

Hilla University College Journal For Medical Science

Background: Coronavirus infection has been the severest pandemic in recent years. Several biomarkers for direct assessment and rapid diagnosis have been used, such as IgM and PCR.

Objectives: The aim of this study was to investigate the critical biomarkers, either a mineral or an enzymatic inhibition or activation.

Materials and Methods: This study was conducted on COVID-19 patients who were suspected of being infected with the coronavirus, using serum of 25–80 years of age, males. The following biochemical tests (LDH, CK-MB, Ferritin, Mg, Zn, Cu and Ceruloplasmin) were measured at a private laboratory in Baghdad.

Results: The results showed that …

Havana To Port-Au-Prince: Cuba’S Medical Internationalism Aid To Haiti, Wilner Saint Cyr

Walden Dissertations and Doctoral Studies

Haiti ranks among the lowest in healthcare quality in the Americas, according to the health indicators used by the World Health Organization. Despite national and international efforts to improve health service delivery, access to primary medical care and preventive services is limited, especially in rural areas. In response to a request from the Haitian government following the devastating Hurricane Georges, the arrival of the first Cuban doctors to support ongoing public health needs commenced in December 1998. Recognizing an opportunity for international cooperation, the Haitian president sought assistance from Cuba by signing a bilateral cooperation agreement for initial and ongoing …

Dynamic Model Of Stunting Incidents And Policies In Padang City, Elsa Yuniarti, Yulhendri Yulhendri, Fitra Arya Dwi Nugraha, Nurhasan Syah, Iswandi Umar, Heldi Heldi, Nabila Azzahra

Media Kesehatan Masyarakat Indonesia

Stunting remains a significant public health challenge with complex, interconnected causative factors. Traditional static approaches fail to capture the dynamic relationships between environmental, health, and socioeconomic determinants. Dynamic modeling is essential for understanding these multifaceted interactions and developing effective prevention policies. Despite declining trends, Padang City's high prevalance of stunting necessitates urgent, targeted interventions to achieve national targets. This study aims to develop a dynamic model analyzing stunting factors in Padang City and formulate effective prevention policies. A quantitative descriptive method with a dynamic systems approach was employed. Primary data were obtained through stakeholder questionnaires, while secondary data were obtained …

Mapping Trends And Patterns In Tuberculosis And Tobacco Use: Insights From A Bibliometric Analysis Of 25 Years Of Research, Meyi Yanti, Erwani Erwani, Radian Ilmaskal, Masrizal Masrizal, Sohel Rana

Media Kesehatan Masyarakat Indonesia

Tuberculosis (TB) and tobacco use represent two of the most pervasive global health challenges, with a particularly profound impact in Low and Middle-Income Countries (LMICs). Although numerous reviews have explored the clinical and epidemiological associations between TB and smoking. A systematic analysis of publication trends is lacking. This study aims to address this gap by providing a comprehensive bibliometric analysis of the intersection between TB and tobacco use, mapping its evolution, key research themes, collaboration networks, and underexplored areas. This study utilized a bibliometric method. Data from 13,876 articles indexed in Scopus were analyzed using RStudio, VOSViewer, and OpenRefine. PLOS …

Validating The Malay Version Of Adolescent Sexual And Reproductive Health Knowledge And Attitudes Questionnaires, Gerraint Gillan Ahi, Md Mizanur Rahman, Rafazila Ramli, Rasitasam Safii, Jacey Lynn Minoi, Stephanie Chua Hui Li, Ahmad Sofian Bin Shminan, Lee Jun Choi

Media Kesehatan Masyarakat Indonesia

Adolescent Sexual and Reproductive Health (SRH) knowledge is crucial for informed decision-making, yet cultural barriers in Malaysia limit open discussions, creating significant knowledge gaps. This study validated the Malay version of the Adolescent SRH Knowledge and Attitudes Questionnaire to address this need. The validation process included expert content review (6 panelists), face validity testing (30 respondents), and psychometric analysis among 100 adolescents in Sarawak. The questionnaire demonstrated excellent content validity as rated by the experts and strong face validity among adolescents. The knowledge domain showed high internal consistency (α = 0.935), while the attitude domain had moderate reliability (α = …

Babaeng Frontliner At Covid-19 Sa Pilipinas: Batayan Para Sa Isang Epektibong Tugon Sa Pandemya Na Nakatuon Sa Gender, Arianne Nicole N. Fernando

Social Sciences and Development Review

While the mortality rates for men are higher, the socioeconomic impact of the COVID-19 pandemic hit women differently. This qualitative study examines the experiences of eight Filipina frontliners who continued to work during the General Community Quarantine in Metro Manila. Respondents were selected through purposive sampling. The primary data collection method was in depth interview. Phenomenological study was utilized for data analysis. The research resulted in three major themes which emerged out of the experiences shared by the female frontliners (1) there exists a problem in safety and transportation among female frontliners; (2) stress develops from a high-risk work task; …