Digital Commons Network^™

Aprepitant Ameliorates Cyclophosphamide-Induced Testicular Toxicity In Mice Via Suppression Of P38 Mitogen-Activated Protein Kinase, Suzan Awad Abdelghany Morsy, Amira H. Eltrawy, Nehal Adel Khalil, Abd Elaziz Mm, Nourhan Mohamed Mohamed Saeed, Gehad M. Khamis

Mansoura Medical Journal

Background: While cyclophosphamide (CP) is a commonly used immunosuppressant and anticancer drug, it has a high risk of testicular toxicity. The current study evaluated the protective and therapeutic actions of aprepitant (APR), a neurokinin-1 receptor blocker, against CP-induced testicular toxicity in mice and the role of oxidative stress and phosphorylated P38 mitogen-activated protein kinase (p-P38 MAPK) in this action.Methods: Forty male mice were assigned to four groups: control (vehicle only), CP-induced testicular toxicity (single 200 mg/kg intraperitoneal CP dose), APRprotected (20 mg/kg/day APR starting one day before CP, continued for 30 days), and APR-treated (same APR dose starting one hour …

Relation Between Serum Vitamin D Level And Disease Activity In Rheumatoid Arthritis, Mohamed Hussein Salem, Nahed Abdullah Hassan, Adel Ibrahim Abdelsalam, Fatma Hamdy

Mansoura Medical Journal

Background The role of vitamin D in the pathogenesis of rheumatoid arthritis is controversial. This study aims to assess the relation between vitamin D level and rheumatoid arthritis disease activity. Patients and methods This study was conducted on 80 rheumatoid arthritis (RA) patients beside 40 healthy persons. Vitamin D level was assessed in all participants. Rheumatoid activity was assessed using DAS28 (disease activity score). RA patients were classified according to DAS 28 into two groups: active group and remission group. Results The median for vitamin D level in RA group was 23.5ng/ml. There was no statistically significant difference in serum …

Ultrasonic Criteria For The Selection Of Rib Graft For Laryngotracheal Reconstruction, Mohamed Abdulaziz Farah, Hazem Emam Amer, Ahmed Abdelfattah Elsobki, Mahitab M. Rashad Ghoneim, Ahmed Abdoo Elzhzahy

Mansoura Medical Journal

Background Laryngotracheal reconstruction (LTR) is a well-established surgical procedure for the management of pediatric subglottic stenosis, with rib cartilage grafts. This study was conducted to evaluate preoperative and intraoperative discrepancies of rib graft used in laryngotracheal reconstruction using ultrasonic criteria in terms of their height, thickness, and length. Methods This prospective cohort study was conducted on 10 pediatric patients who underwent LTR at Mansoura University Hospitals. Preoperative ultrasonography was performed on the right 4th, 5th, and 6th rib cartilages, measuring height, thickness, and length. These measurements were then directly compared with intraoperative dimensions of the harvested cartilage. Results There was …

The Association Between Stress-Related Disorders And Chronic Pelvic Pain Syndrome In Males: A Narrative Review, Abdinur Jama Farah, Mohammed Hegazy Abdulhalem, Wafaa Abdel-Hakim El-Bahaey, Ahmed Sobhy El Hefnawy

Mansoura Medical Journal

Background Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) in males is a multifactorial clinical syndrome with significant impact on quality of life (QoL). Objective To explore the link between psychological stress and chronic pelvic pain in males through reviewing the relevant articles in CPPS literature. Review summary CPPS in males is a complex condition marked by persistent pelvic pain, urinary symptoms, and sexual dysfunction without identifiable infection or pathology. Its unclear etiology and significant impact on quality of life make it a challenging clinical problem. Growing evidence suggests that psychological stress plays a key role in symptom onset and persistence by …

Evaluation Of Serum Ischemia Modified Albumin Level In Male With Androgenic Alopecia, Eman Elnigomy Mahmoud Elnigomy, Fawzia Ameen Saafan, Noha Mohamed Sherif Salah, Mohammed Samir Sultan

Mansoura Medical Journal

Introduction Androgenic alopecia (AGA) is the most common type of progressive hair loss in men, influenced by genetic and hormonal factors. Recent studies suggest that oxidative stress may play a role in its pathogenesis. Serum ischemia-modified albumin (IMA), a biomarker of oxidative stress, could provide insights into disease activity and severity in AGA patients. Aim The purpose of this study was to evaluate serum level of ischemia-modified albumin in male patient with androgenetic alopecia in comparison with healthy control. Patients and Methods This case-control study included 45 male patients with androgenetic alopecia and 45 age- and sex-matched healthy controls, recruited …

Outcomes Of Expansion Sphincter Pharyngoplasty In Multilevel Lateral Pharyngeal Wall Collapse In Obstructive Sleep Apnea, Esraa Moustafa, Hisham Atef Ebada, Ahmed El-Sobki, Mohamed Mostafa Elsaher

Mansoura Medical Journal

Background: since its introduction in 2006, Since its introduction, expansion sphincter pharyngoplasty (ESP) has demonstrated significant efficacy in the management of pharyngeal collapse among patients with obstructive sleep apnea syndrome (OSAS). The aim of the current study is to investigate the effectiveness of ESP in multi-level pharyngeal wall collapse in patients with OSAS. Methods: This prospective study was conducted in the Otorhinolaryngology Department, Faculty of Medicine, Mansoura University, Egypt over 1.5 years (June 2023 – December 2024). The study included 29 patients with OSAS who underwent ESP to manage multilevel pharyngeal wall collapse. The outcomes were evaluated based on the …

Interplay Between Amiodarone And Statins: Experimental Evidence Of Synergistic Hepatotoxicity, Hager Zaki Elghareb, Abdel-Motaal M. Fouda, Mohamed Mahmoud Elhadidi, Ahmed Abdel-Monem Elmetwally

Mansoura Medical Journal

Background: Drug-induced liver injury (DILI) continues to be a main contributor to acute liver failure. So, this study aimed to investigate interactions between amiodarone and atorvastatin concerning hepatic safety, due to increasing clinical practice of their combination for optimal arrhythmia control. Methods: Forty male Sprague Dawley rats were randomly divided into four groups (10 in each group). Group 1 was control group receiving normal saline. Group 2 received Amiodarone-only \ (administered 30 mg/kg/day orally). Group 3 received Atorvastatin only (administered 10 mg/kg/day orally). Group 4 received combination of both amiodarone and atorvastatin in same previous doses. All drugs were dissolved …

Study Of Heat Shock Protein 70 In Serum Of Cancer Breast Patients, Dina Adel Denewer, Fatma Abbas Auf, Khaled M. Abdelwahab, Mona Elwassefy

Mansoura Medical Journal

Background Breast cancer (BC) is the most frequent malignancy affecting women worldwide. Heat shock proteins (HSPs) are a family of proteins that are important for the maintenance of cell homeostasis. HSPs have been overexpressed in many tumours, including BCs, lung, gastric, ovarian, endometrial and colon Aim To evaluate the relation between serum levels of HSP70 and BC in Egyptians and its impact on tumour characteristics and different histopathological types of BC. Methods This a case-control study conducted on 70 cases of newly diagnosed BC and the control group included 19 apparently healthy age and sex matched subjects. Full clinical examination …

Comparison Of The Efficacy Of Topical Cetirizine 1% Versus Topical Minoxidil 5% Solution In Treatment Of Male Androgenetic Alopecia, Hadeer Samy Abd-Elfattah, Bothaina Mahrous Ghanem, Farid Abd-Elreheim Badria, Mohammed Samir Sultan

Mansoura Medical Journal

Background: Androgenetic alopecia (AGA) is a common form of non-scaring hair loss characterized by extensive miniaturization of scalp hair follicles. Minoxidil is a standard topical treatment. Cetirizine, an antihistamine with anti-inflammatory properties, may be beneficial by modulating prostaglandins—specifically by inhibiting PGD2 and promoting PGE2, both of which have essential roles in hair cycle regulation. Aim: To compare the efficacy and safety of topical cetirizine 1% versus minoxidil 5% in treating male AGA. Patients and Methods: Forty male patients were randomly allocated in this randomized controlled study to receive topical cetirizine 1% or minoxidil 5%. Clinical photographs and dermoscopic evaluations were …

Relationship Between Down Syndrome And Attention Deficit Hyperactivity Disorder And The Role Of Fkbp5 Gene: A Review Of Current Evidence, Israa A. Elsawi, Dina Salama Abd-Elmagid, Doaa Shahin, Mohamed Rizk Khodair, Sohier Yahia

Mansoura Medical Journal

The most prevalent chromosomal disorder is Down syndrome (DS). Neurodevelopmental disorders are highly associated with Down syndrome, such as attention deficit hyperactivity disorder (ADHD). Down syndrome is also distinguished by intellectual disability and developmental delays, with many affected individuals presenting manifestations of ADHD like inattention or hyperactivity. Differentiating ADHD from overlapping DS-related cognitive deficits remains a diagnostic dilemma. The FKBP5 gene, particularly the rs7748266 polymorphism, has been implicated in modulating stress response pathways linked to ADHD susceptibility. This review summarizes the relationship between DS and ADHD and explores the emerging role of FKBP5 rs7748266 in this context. This may later …

Cyclooxygenase-2 Gene Variant In Egyptian Patients With Type 2 Diabetes Mellitus With Correlation To Lipid Profile And Markers Of Oxidative Stress, Shereen A. Mourad, Mohammed M. El Arman, Abeer Mesbah, Amany R. Youssef, Tarek Gouda, Hyam Sameh Nada, Doaa A. El-Hanafy

Mansoura Medical Journal

Background: Cyclooxygenase-2 (COX-2) is an enzyme responsible for the conversion of arachidonic acid into prostaglandins. Despite previous studies, there is controversy considering the exact role of COX-2 in the pathogenesis of type 2 diabetes mellitus (T2DM) and its related adverse cardiovascular events. We aimed to examine the association between COX-2 rs20417 genetic polymorphism with increasing susceptibility to T2DM and whether it enhances the development of cardiovascular complications in T2DM. Methods: A total of 244 individuals were recruited, including 164 T2DM patients (further subdivided into uncomplicated and cardio-complicated cases) and 80 healthy control subjects. The different genotypes for the COX-2 rs20417 …

Evaluation Of Safety And Efficacy Of Autologous Platelet-Rich Fibrin In The Treatment Of Psoriasis Vulgaris, Hajar Esamelddin, Maha Elgyyar, Mohamed Sultan

Mansoura Medical Journal

Background: Psoriasis is a chronic, immune-mediated dermatosis characterized by dysregulated cutaneous immunity. Platelet-rich fibrin (PRF), an autologous biomaterial concentrated with immunomodulatory cytokines and growth factors, presents a potential novel therapeutic approach by modulating localized inflammatory pathways. Objective: This study aimed to assess the efficacy and safety of a topical and intralesionally autologous PRF protocol in patients with localized plaque psoriasis. Methods: In a prospective single-arm trial, sixty adults with mild-to-moderate localized plaque psoriasis (BSA ≤10%, PASI ≤10) were enrolled. PRF was prepared from peripheral blood via low-speed centrifugation without anti-coagulant. Treatment involved bi-weekly intralesionally injections and topical massage of the …

Comparison Of Baumgaertner Reduction Quality Criteria , Chang Criteria And Ap3×Ml3 Classification And Their Ability To Predict Mechanical Complications Of Trochanteric Fractures Fixed With Proximal Femoral Nail, Amr Elhadidy Elhadidy, Ahmed Abdelbadie Ibrahim, Sallam Ibrahim Fawzy, Ehab Youssef Hassanin

Mansoura Medical Journal

Background Trochanteric fractures are common injuries among the elderly. Despite advances in fixation with proximal femoral nails (PFN), Mechanical complication remain significant. Several reduction quality systems have been proposed, but their predictive value and reproducibility remain debated. Aim To evaluate and compare the predictive value and reproducibility of Baumgaertner Reduction Quality Criteria (BRQC), Chang Reduction Quality Criteria (CRQC), and AP3×ML3 classification in patients with AO Foundation/Orthopaedic Trauma Association (AO/OTA) 31-A1 and 31-A2 trochanteric fractures fixed with PFN. Methods A prospective observational study was conducted on 146 patients with 31-A1 and A2 trochanteric fractures treated by PFN. Postoperative radiographs were assessed …

Application Of The Papanicolaou Society Of Cytopathology (Psc) System For Reporting Endoscopic Ultrasound-Guided Fine-Needle Aspiration (Eus-Fna) Of Pancreatic Lesions, Sara Saad Abd El-Razik, Rehab Talaat El-Desoky, Khadiga Mohamed Ali, Amal Abd El Hafez

Mansoura Medical Journal

Background: The Papanicolaou Society of Cytopathology (PSC) Reporting System presented a six-category classification system to stereotype the pathological clarification of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) samples. This study aimed to evaluate the accurateness of the PSC system in interpreting and reporting EUS-FNA of pancreatic lesions. Methods: A retrospective study with inter-observer analysis was performed on cytological samples got from patients who experienced EUS-FNA for pancreatic lesions from January 2018 to December 2022. Smears were observed by pathologists who were blinded to the final radiologic and pathologic data, applied the criteria of PSC System. Statistical examination was performed. Results: The study …

Role Of Calbindin2 In Male Infertility With Oligozoospermia And Asthenoteratozoospermia, Ashraf H. A. Hassan, Adel A. E. Zalata, Sherif R. Ismail, Hebatullah Ahmed Elsayed

Mansoura Medical Journal

Introduction: Male infertility may account for almost half of all cases of infertility. This is commonly linked to compromised sperm characteristics, such as shape, concentration, and motility. Recent studies have suggested a role for calcium-binding proteins, including Calbindin 2 (CALB2), in spermatogenesis and male reproductive function. Aim: The purpose of this study was to assess the association between male infertility in cases of oligozoospermia and asthenoteratozoospermia and seminal Calbindin 2 levels. Patients and Methods: A case-control study was performed on 90 men (45 infertile, 45 fertile controls). Semen parameters, oxidative stress, hormone levels, DNA fragmentation, acrosin activity, and seminal CALB2 …

Clinical And Radiological Outcomes Of Posterior Malleolar Fractures Fixation Through Posterolateral Approach: A Prospective Case Series Study, Mohammed Abdulrafei Farag, Ahmed Elsayed Elhawary, Ahmed Salah-Eldeen Zaghloul

Mansoura Medical Journal

Background: Posterior malleolar fractures are frequently associated with other malleolar injuries and significantly affect ankle stability through the posterior tibiofibular ligament. CT imaging is vital for preoperative classification, fragment size measurement, and syndesmotic evaluation. Objective: To assess clinical and radiological outcomes of posterior malleolar fractures treated using the posterolateral approach. Methods: This prospective case series included 20 skeletally mature patients treated between March 2022 and January 2024. Preoperative evaluation included radiographs and CT scans for classification, fragment size, articular step-off, and syndesmotic injury. Postoperative reduction and alignment were assessed with X-ray and CT. Functional outcomes were evaluated at ≥6 months …

New Modifications Of The Loop Electrosurgical Excision Procedure (Leep) For The Management Of Cervical Lesions In The Low Resource Conditions, Amal Abdulrahman Al-Kbous, Rafik Ibrahim Barkat, Mohamed A. Elnegeri, Amany A. Makroum, Reda Abdelhadi Hemida Dr.Reda Hamida, Mohamed Elsayed Taman

Mansoura Medical Journal

Background: Cervical intraepithelial neoplasia (CIN) encompasses a range of abnormal changes within the cervical squamous epithelium and is regarded as a precursor to invasive squamous cell carcinoma of cervix. Management of CIN-1 generally involves follow-up with repeat testing after one year, while CIN-2 and higher lesions require treatment aimed at complete removal of the lesion and transformation zone using ablative or excisional methods such as Loop electrosurgical excision (LEEP), or cold-knife cone biopsy. This study aimed to test applying a new modification on LEEP to facilitate its use in the management of cervical lesions in the low resource conditions regarding …

Association Of Uric Acid Index And Cardiovascular Risk In Egyptian Patients With Type 2 Diabetes, Reem Fathallah, Talaat Abdelaaty, Hend Ghallab, Shimaa M. Elrahmany

Mansoura Medical Journal

Background The uric acid index (UAI) has recently gained recognition as a potential indicator for cardiovascular risk, particularly among middle-aged individuals. This research investigated the association between UAI levels and cardiovascular disease risk in Egyptian patients with type 2 diabetes (T2DM). Methods 200 individuals with T2DM were included in this cross-sectional analysis. The UAI was derived using the logarithmic formula: Ln [fasting triglycerides × fasting uric acid × fasting glucose ÷ 2]. To estimate the 10-year risk of cardiovascular events, the SCORE2-Diabetes was employed. Results The average serum uric acid level was 4.40 ± 1.48 mg/dL, and the mean UAI …

Oncologic Outcome Of Hemithyroidectomy For Low Risk Patients With Well Differentiated Thyroid Carcinoma, Yasser Sharaf El Din, Khaled Gaballa, Mohamed Attia, Mohamed A. Hegazy

Mansoura Medical Journal

Background: The incidence of well-differentiated thyroid cancer (WDTC) has increased in recent decades, yet most cases remain indolent and categorized as low-risk, typically associated with excellent prognoses. The rising identification of these tumors has led to continued discussion about optimal surgical management. In recent years, there has been a clear trend in the evolution of guidelines addressing surgical management of WDTC toward de-escalation, including hemithyroidectomy, for appropriately selected low-risk WDTC patients. Methods: We performed a retrospective case series included 24 individuals with an incidentally discovered and pathologically proven diagnosis of WDTC following hemithyroidectomy, over a five-year period (January 2018-December 2022) …

Evaluation Of Serum Zinc-To-Copper Ratio In Adults With Type 2 Diabetes And Its Association With Microvascular Complications, Magdy H. Megallaa, Shimaa M. Elrahmany, Rehab Safwat, Mohamed Zietoun

Mansoura Medical Journal

Background Zinc (Zn) and copper (Cu) are indispensable trace metals that contribute fundamentally to insulin biology, antioxidant defense, and vascular health. In this research, we sought to explore the association between the serum zinc-to-copper (Zn/Cu) ratio and microvascular complications among adults diagnosed with type 2 diabetes (T2DM). Methods For this case-control design, a total of 336 participants were selected and divided into two main groups: Group 1, comprising 224 patients with T2DM, and Group 2, consisting of 112 healthy subjects serving as controls. Group 1 was further stratified into two subgroups based on the presence of microvascular complications; Group 1A …

Treatment Of Xanthelasma Palpebrarum With Plasma Energy Device, Merna Azab, Fawzia A Saafan, Amal Wagdy

Mansoura Medical Journal

Background: Semisolid, yellowish deposits known as Xanthelasma palpebrarum (XP) may develop at the inner and outer corners of the eyelids. The goals of ideal XP treatment are complete clearance with no recurrence, ensuring safety, comfort, and affordability, with no or minimal undesirable side effects, including pigmentary changes or scarring. One non-ablative electrosurgical method is plasma sublimation therapy, which involves generating plasma from atmospheric gas using radio frequency energy. This process creates ionized and mixed chemicals, which then sublimate epidermal tissue. Aim: to evaluate the efficacy of plasma energy devices in treatment of xanthelasma palpebrarum. Patients and methods: The current study …

Low-Carbohydrate, Low-Fat, And Balanced Diets In Weight Reduction Among Obese Adolescents., Ashraf A. Elsharkawy, Gihan Fouad Ahmad, Ahmed El-Husseiny, Amany K. Elhawary, Ola Shawky Ahmed, Asmaa Taha Zaher Taha, Fatma El-Zahraa M. Hashish

Mansoura Medical Journal

Background: Obesity in adolescents is a major public health concern, leading to early onset of metabolic abnormalities. This study aimed to compare the effects of the Low- Carbohydrate Diet (LCD) and Low-Fat Diet (LFD) in comparison with the balanced calculated diet (BCD) on weight reduction in obese adolescents and their impact on metabolic health markers. Patients and methods: 75 obese adolescents aged less than 18 years were enrolled in this prospective, randomized, controlled study and were randomly assigned to either LCD group, LFD group, or BCD group. Anthropometric and laboratory measures were collected before and after a 10-week intervention. Results: …

Vitamin D Status In Coronary Artery Disease, Yasmeen M. Zayed, Hamdy F Marzouk, Alshaimaa H. Abd-Elmaksoud, Ahmed H. Eladawy, Shereen A Mourad

Mansoura Medical Journal

Background: Vitamin D deficiency, dyslipidemia, and systemic inflammation are recognized contributors to coronary artery disease (CAD), so the aim of this study was to assess association of serum vitamin D (25(OH)D), traditional and nontraditional lipid indices, and neutrophil lymphocyte ratio (NLR) with CAD risk and severity, and to evaluate their predictive value using the Gensini score. Methods: A cross-sectional study included 55 CAD patients (group I) and 55 age- and sex-matched individuals (group II). lipid profiles, NLR, and serum 25(OH)D levels were measured. Nontraditional lipid indices, including Castelli’s Risk Indices and atherogenic coefficient were calculated. The severity of CAD was …

Impact Of Insulin Resistance And Obesity Indices On Patients Received Recombinant Tissue Plasminogen Activator (R-Tpa) In Acute Ischemic Stroke, Manar Hamada Abou El-Wafa, Azza E. Elmongui, Ahmed Saad Almenshawy, Nada Abd Elhameed Elsaid

Mansoura Medical Journal

Background Insulin resistance (IR) and obesity may influence stroke outcomes after recombinant tissue plasminogen activator (r-TPA) therapy. The aim of this work was to analyze the potential impact of IR, body mass index (BMI) and relative fat mass on stroke prognosis in non-diabetic patients after intravenous thrombolytic therapy Methods This Cross-sectional observational study was conducted on 44 patients, with acute ischemic stroke (AIS) received r-TPA. Every single patient underwent routine laboratory examination in addition to serum insulin and assessment of insulin resistance (IR) by the HOMA-IR index (defined as HOMA-IR>2.5). Body mass (BMI), relative fat mass (RFM) indices and …

Sexual Dysfunction After Hysterectomy Based On Female Sexual Function, Elsayed M. Abd Elfattah, Amany A. Makroum, Mohamed A. Fekry, Mohamed Sayed Abdelhafez, Maher Shams, Ahmed El Mennayyer

Mansoura Medical Journal

Abstract Hysterectomy is the most common major gynecological surgical procedure. There are raised concerns regarding its impact on sexual function. Objective: This study aimed to assess the effects of vaginal, abdominal, and laparoscopic hysterectomy on women’s sexual functioning based on the female sexual function index (FSFI). Methods: This prospective Cohort study was conducted on 48 patients who underwent hysterectomy by different routes at the OB/GYN department at Mansoura University Hospitals, Mansoura, Egypt, aged between 25 and 49 years, from October 2024 to October 2025. The patients’ sociodemographic and clinical data were collected. The patients were asked to fill the FSFI …

Food Allergies And Quality Of Life In Older Adults: Development Of A Food Allergy Questionnaire, Avalon F. Mustafa

UNF Graduate Theses and Dissertations

The United States is experiencing a rapid increase in the number of older adults, yet there is a lack of research on food allergies in this demographic. While there are survey instruments available to study food allergies and quality of life, none of these are tailored to the unique needs of elderly individuals. This study aims to create and validate an on-line survey instrument specifically designed for older adults, focusing on their quality of life in the context of food allergies. The survey will be used to establish a food allergy severity score and a quality-of-life score, enabling comparison between …

Indications Of Hospitalization And Predictors Of Outcome Among Patients With Rheumatological Diseases Admitted To Mansoura Rheumatology And Immunology Unit, Hanan Mohamed Elberashi, Nibal Morad, Samar Tharwat

Mansoura Medical Journal

Background correction: Systemic autoimmune rheumatological diseases (SARDs) constitute a category of disorders that can affect several organs. SARDs are persistent, incapacitating illness characterized by significant morbidity and mortalityrates. Patients with SARDs necessitate hospitalization more frequently than the general population.

Aim: To determine the characteristics of patients hospitalized with SARDs at Mansoura University Hospital.

Materials and methods: This cross-sectional study was carried out on patients with different SARDs. The collected data

included patients’ sociodemographic data, autoimmune disease diagnoses, the onset and duration of the disease, rate of

readmission, the main cause of admission, the main organ affected at time of admission, …

Effect Of Dexmedetomidine Versus Magnesium Sulfate On Intraocular Pressure In Glaucoma Surgery: A Randomized Controlled Trial, Nourhan E. Elhadidi, Nevert A. Abdelghaffar, Nabil A. Mageed, Amany Tarbay

Mansoura Medical Journal

Background : Lowering the intraocular pressure (IOP) is regarded as a primary and initial treatment option for glaucoma. Dexmedetomidine and Magnesium sulfate are known to have intraocular pressure-lowering effects which improve visual fields in patients with primary open angle glaucoma and attenuate intraocular pressure spikes induced by tracheal intubation. Aim: To evaluate and compare the safety and efficacy of using Dexmedetomidine versus Magnesium Sulfate on intraocular pressure and the incidence of postoperative hyphema. Methods : This study included 100 patients both male and female with American Society of Anesthesiologists (ASA) physical status class ɪ and ɪɪ scheduled to undergo elective …

Efficacy Of Intradermal Injection Of Tranexamic Acid And Ascorbic Acid Versus Tranexamic Acid And Placebo In The Treatment Of Melasma: A Split-Face Comparative Trial, Wafaa H. A. Mahmoud, Bothaina M. Ghanem, Amal Wagdy

Mansoura Medical Journal

Background: Melasma is a common hyperpigmentation disorder affecting millions worldwide. This study was done to evaluate effectiveness of combined intradermal injections of Tranexamic acid (TxA) and ascorbic acid compared to TxA alone with placebo in managing facial melasma. Methods: This randomized controlled study included twenty patients diagnosed with epidermal melasma were divided into two groups. In Group A, one side of the face received 0.5 ml of TxA (50 mg) with 0.5 ml of normal saline; in Group B, the other side received 0.5 ml of TxA plus 0.5 ml of ascorbic acid. Treatment efficacy was assessed by measuring the …

Role Of Magnetic Resonance Diffusion Tensor Imaging In Differentiating Osteomyelitis From Osteoarthropathy In Diabetic Foot, Mona Mohamed Hamid Ibrahim Barakat, Saher Ebrahim Taman, Samer Abdelhamid Regal, Ahmed Galal Sadek

Mansoura Medical Journal

Background: Diabetic foot ulcer (DFU) represents a major cause of preventable morbidity among adults with diabetes mellitus (DM). Diabetic foot osteomyelitis (DFO) frequently arises through contiguous spread of soft tissue infection to the underlying bone. Diffusion tensor imaging (DTI) is an advanced magnetic resonance imaging (MRI) technique that enables quantitative evaluation of tissue microstructure. Aim: To assess the diagnostic value of magnetic resonance DTI in differentiating osteomyelitis from acute osteoarthropathy in patients with diabetic foot complications. Methods: This prospective study included 28 diabetic patients presenting with clinically suspected foot complications. According to the final diagnosis, patients were classified into two …