Digital Commons Network^™

Intrinsic Motivation Teaching Experiences Of Middle School Educators 4 Years After The Pandemic, Carmy Aristor

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic has altered the educational landscape, significantly impacting middle school educators’ intrinsic motivation to teach. While research has extensively addressed the immediate impacts of the pandemic on education, there remains a gap in understanding how middle school educators make sense of their intrinsic motivation teaching experiences 4 years after the pandemic. Grounded in intrinsic motivation as the conceptual framework supported by the self-determination theory (SDT), the purpose of this qualitative study was to gain an understanding of the intrinsic motivation teaching experiences of middle school educators 4 years after the pandemic. The central research question examined the lived …

Epigenetic Profiling Of Cell-Free Dna In Cerebrospinal Fluid: A Novel Biomarker Approach For Metabolic Brain Diseases, Kyle Sporn, Rahul Kumar, Kiran Marla, Puja Ravi, Swapna Vaja, Phani Paladugu, Nasif Zaman, Alireza Tavakkoli

SKMC Student Presentations and Publications

Due to their clinical heterogeneity, nonspecific symptoms, and the limitations of existing biomarkers and imaging modalities, metabolic brain diseases (MBDs), such as mitochondrial encephalopathies, lysosomal storage disorders, and glucose metabolism syndromes, pose significant diagnostic challenges. This review examines the growing potential of cell-free DNA (cfDNA) derived from cerebrospinal fluid (CSF) epigenetic profiling as a dynamic, cell-type-specific, minimally invasive biomarker approach for MBD diagnosis and monitoring. We review important technological platforms and their use in identifying CNS-specific DNA methylation patterns indicative of neuronal injury, neuroinflammation, and metabolic reprogramming, including cfMeDIP-seq, enzymatic methyl sequencing (EM-seq), and targeted bisulfite sequencing. By synthesizing current …

Mental Health In Prisons: Examining Variations In Disorders Across Custody Levels, Ariel Bysiek

Dissertations and Theses

The United States has a significantly large prison population with the number of people currently in a correctional facility being 1.9 million. Concern has been increasingly growing related to treatment of individuals in prison, particularly when it comes to solitary confinement. Many people believe that solitary confinement is unnecessarily cruel and debilitating to AIC's mental health. Studies have found contradicting information as to whether solitary impacts mental health. Part of the reason for this contradiction stems from the lack of measurement systems that are appropriate for AICs. The measures used in studies are meant for the general population, not individuals …

Genetic Control Of Sweetness And Acidity In Blackberry, Carly Godwin, T. Mason Chizk, Carmen John, Lacy Nelson, Renee Threlfall, John R. Clark, Margaret L. Worthington

Horticulture Faculty Publications and Presentations

Introduction The global blackberry (Rubus subgenus Rubus) industry has experienced rapid growth during the past 20 years. Even so, many industry stakeholders report complaints from consumers and grocers stating that blackberries are often too tart or not sweet enough for their palate. Studies have shown that most consumers prefer sweet blackberries with relatively low acidity, but little research has been conducted to understand the genetic control of these traits in Rubus.Methods The objective of this study was to identify quantitative trait loci (QTL) related to sweetness and acidity in autotetraploid blackberry using a genome-wide association study (GWAS). A panel consisting …

From Feedback To Framework: Improving Mentorship Through Resident Insights In Scholarly Activity, Eleni Mastrokalos, Angela Colistra Lpc, Phd, Ms

Research Scholars

No abstract provided.

Adherence To The 2022 Down Syndrome Guidelines In Children Less Than 18 Years Of Age In The Greater Lehigh Valley Area, Constance Mulligan, Christopher P. Raab Md, Ms

Research Scholars

No abstract provided.

Impact Of The Junior Research Scholar Program At Lehigh Valley Health Network (Lvhn), Part Of Jefferson Health, Yashimabet Burke, Kerri Green Edd, Ms

Research Scholars

No abstract provided.

Mechanical Circulatory Device Impella Usage In Patients With Cardiogenic Shock On Ecmo Support, Julia Pekala, James K. Wu Md, Bryan D. Nelson Mba, Cphq, Nrp

Research Scholars

No abstract provided.

A National Hospital Review And Community Survey: Assessing Fall Risk Concern And Fall Prevention Program Awareness Among Older Adults, Luciana Carnero, Kendal Davis, Daniel Patruno, Doree Feldman Md, Mba

Research Scholars

No abstract provided.

A Hairy Situation: Investigating Facial Hair's Role In Central Line Dressing Integrity, Jaylen Lesser, Elisa C. Moyer Bsn, Rn, Cen, Jonathan T. Berback Mph, Cic, Joseph Yashur Bsph, Brenda Croll-Stachelek Msn

Research Scholars

No abstract provided.

Hearing The Call: The Need For An Evangelical Theology Of 'Intentional Christian Community' And Consecrated Life At Taylor University In The 21st Century, Hank Voss

Presentations

Taylor University's Life Together Covenant calls the university "a covenant community of Christians . . . intentionally joining together for academic progress, personal development, and spiritual growth." This paper presented at the 2025 Intentional Christian Communities Explorer's Gathering argues for a theological understanding of Taylor University's intentional Christian community as a consecrated Christian sodality with a specific second-order commitment, a community rule, symbolic vestiture, leadership structures, and a specific charism for the larger church.

Classroom Enrichment-Based Energy-Exhaustion Games And Their Impact On Developing Selected Social Skills And Physical Attributes And Reducing Hyperactivity And Attention Deficit In Gifted Students, Nihad Mohammed Alwan, Ali Sadiq Dhiyab, Doaa Muhib Al-Din Ahmed, Farah Alaa Jafar

Modern Sport

The significance of this research lies in exploring the impact of energy-exhausting games through enrichment classroom activities on the development of specific social skills and physical attributes, as well as reducing hyperactivity and attention deficit among gifted students aged 13. The research problem emerged from the question: To what extent can energy-exhausting games, when implemented through enrichment classroom programs, contribute to enhancing selected social and physical traits and minimizing hyperactivity and attention deficit? This study aimed to (a) identify the levels of specific social skills in the sample, (b) identify the values of specific physical attributes in the sample, (c) …

U-Rich Elements Drive Pervasive Cryptic Splicing In 3' Utr Massively Parallel Reporter Assays, Khoa Dao, Courtney F Jungers, Sergej Djuranovic, Anthony M Mustoe

2020-Current year OA Pubs

Untranslated RNA sequences play essential roles in orchestrating gene expression. However, the sequence codes and mechanisms underpinning post-transcriptional regulation remain incompletely understood. Here, we revisit the finding from a prior massively parallel reporter assay (MPRA) that AU-rich elements in 3' untranslated regions (3' UTRs) can drive upregulation or downregulation of mRNA expression depending on 3' UTR context. We unexpectedly discover that this variable regulation arises from widespread cryptic splicing, predominately from an unannotated splice donor in the coding sequence of GFP to diverse acceptor sites in reporter 3' UTRs. Splicing is activated by U-rich sequences, which function as potent position-dependent …

Phase 1b/2 Study Evaluating Safety, Efficacy And Immune Effects Of Tlr9 Agonist Cavrotolimod With Anti-Pd-1 Antibodies Among Patients With Advanced Solid Tumors, Mohammed M Milhem, George Ansstas, Et Al.

2020-Current year OA Pubs

BACKGROUND: There is an unmet need for novel immunotherapies to overcome immune evasion in patients with advanced skin cancers resistant to programmed death (PD)-1 / PD-ligand 1 (PD-L1) blockade. Cavrotolimod is a novel spherical nucleic acid configuration of a toll-like receptor 9 agonist oligonucleotide, designed to trigger innate and adaptive immune responses to tumors.

PATIENTS AND METHODS: The safety, pharmacokinetics, pharmacodynamics and preliminary efficacy of intratumoral cavrotolimod, first dosed alone and then in combination with anti-PD-1 antibodies (pembrolizumab or cemiplimab), were assessed in a combined Phase 1b/2 dose escalation/dose expansion study in patients with advanced skin cancers, including melanoma, Merkel …

Be Mindful: Examining A Brief Mindfulness Intervention On Educator Well-Being, Oceann S. Gittens

LSU Doctoral Dissertations

Teaching is currently rated as one of the topmost stressful occupations. Concerningly, chronic levels of stress can lead to poor mental and physical health, occupational burnout, and teacher attrition; all of which have a negative impact on student outcomes. Mindfulness-based interventions (MBIs) are commonly used to combat occupational stress by enhancing educator well-being. There is compelling evidence to support these types of interventions with teachers. However, the length of many MBIs may make them prohibitive for the average educator to participate in them. The literature suggests that a briefer format may be just as effective at reducing stress, but more …

Replication Of Sensor-Based Categorization Of Upper-Limb Performance In Daily Life In People Post Stroke And Generalizability To Other Populations, Chelsea E Macpherson, Marghuretta D Bland, Christine Gordon, Allison E Miller, Caitlin Newman, Carey L Holleran, Christopher J Dy, Lindsay Peterson, Keith R Lohse, Catherine E Lang

2020-Current year OA Pubs

BACKGROUND: Wearable movement sensors can measure upper limb (UL) activity, but single variables may not capture the full picture. This study aimed to replicate prior work identifying five multivariate categories of UL activity performance in people with stroke and controls and expand those findings to other UL conditions.

METHODS: Demographic, self-report, and wearable sensor-based UL activity performance variables were collected from 324 participants (stroke

RESULTS: Two PCs explained 70-90% variance: PC1 (overall UL activity performance) and PC2 (preferred-limb use). A five-variable, five-cluster model was optimal across samples. In comparison to clusters, two PCs and individual accelerometry variables showed higher convergent …

Unpacking Digital Transformation – Constructing A Framework Based On Industry Use Cases, Khawaja Asjad Saeed, Andrew William Green, Alison Brooke Hedrick

Faculty Articles

Based on industry use cases, we identify six distinct types of digital transformation (DT), each grounded in a specific concept or enabling technology. These DT types can be implemented individually or combined to drive transformation initiatives. While deploying a single DT type often focuses on improving operational efficiency or streamlining existing workflows, initiatives that combine multiple DT types tend to pursue more ambitious goals, such as the creation of new products, services, or business models. However, the complexity increases significantly with the integration of multiple DT types, as organizations must not only address behavioral changes but also overcome technical challenges …

Analysis Of Consistent Self-Care And Mobility Scoring Across The Inpatient Continuum, Makenzie Epting, Kasey Hutter Ms, Ccc-Slp, Michael Pechulis Dpt, Christopher Johns Pt, Dpt, Ocs, Cert. Mdt

Research Scholars

No abstract provided.

Impacts Of Care Navigation On Patient Readmissions Post Total Joint Replacement Surgery, Prajeet Santra, Teresa Latvis Ma, Bsn, Rn, Jessica Snyder Bsn, Rn, Carissa Hrichak Mba, Bsn, Rn

Research Scholars

No abstract provided.

Hepcidin Overexpression In Burn Patients Causes Decreased Red Blood Cell Synthesis, Joshua Rushing, Sigrid A. Blome-Eberwein Md, Gordon Lindberg Md, Nadine Koenig Bmst, Tc-Nrcc, Cynthia Berger Bmst-Ascp, Elizabeth Berger, Tomas Ganz

Research Scholars

No abstract provided.

Barriers Preventing Discharges Home Before Noon, Julia Sealing, Heather Faust Msn, Rn, Cmsrn, Karanda Erdman Bsn, Rn

Research Scholars

No abstract provided.

Outcomes Of Acute Infective Endocarditis With Antibiotic Treatment In Cardiothoracic Surgery, Ella Amadio, James K. Wu Md, Bryan D. Nelson Mba, Cphq, Nrp

Research Scholars

No abstract provided.

Characterization Of Necrotizing Enterocolitis (Nec) In Neonatal Patients, Jeremy Sumner, Kristin Held Wheatley Pharmd, Bcop, Tibisay Villalobos-Fry Md

Research Scholars

No abstract provided.

Insufficient Pap Smear Results In Transgender Male Patients, Ella Choi, Patricia L. Mara Md

Research Scholars

No abstract provided.

Cholecystectomy Outcomes Following The Implementation Of Robotic Surgery At Lvh-M, Amber Unger, Kathryn L Wheel Md, Joseph J. Stirparo Md

Research Scholars

No abstract provided.

The Influence Of Renal Function On 30-Day Post-Coronary Artery Bypass Graft Surgery Readmissions, Hanna Sumner, Rosemarie Incorvaia, Bryan D. Nelson Mba, Cphq, Nrp, James K. Wu Md

Research Scholars

No abstract provided.

Quality Improvement Project To Increase Utilization Of Oral Step-Down Therapy For Prosthetic Joint Infections (Pji), Juliane Kallenbach, Amy Slenker Md

Research Scholars

No abstract provided.

Emergency Department (Ed) Patients With A Sepsis Alert Discharged With A Prescription For Oral Antibiotics, Mckenna Dempsey, Jarrod W. Kile Rphd, Megan Taylor Pharmd, Eric Young Md

Research Scholars

No abstract provided.

Commonalities Of 30-Day Readmitted Coronary Artery Bypass Graft Surgery Patients, Rosemarie Incorvaia, Hanna Sumner, James K. Wu Md, Bryan D. Nelson Mba, Cphq, Nrp

Research Scholars

No abstract provided.

Inhibition Of The Caveolin-1 Pathway Promotes Apoptosis And Overcomes Pan-Tyrosine Kinase Inhibitor Resistance In Hepatocellular Carcinoma, Tasnuva D. Kabir, Samuel Beck, Lisa M. Stuart, Ji Li, Rui Hou, Peiwen Liu, Shelby Margolius, Claire Kim, Yu Suk Choi, Edward R. Bastow, Dianne J. Beveridge, Lisa Spalding, Ziyi Li, Florent Ginhoux, Pierce Chow, Michael Phillips, Andrew D. Redfern, George C. Yeoh, Alistair Forrest, Andrew J. Woo, Ankur Sharma, Jacob George, Geoffrey Mccaughan, Peter Leedman

Research outputs 2022 to 2026

Resistance to multi-tyrosine kinase inhibitors (TKI) is a major clinical concern in advanced hepatocellular carcinoma (HCC). Herein, we aimed to uncover the mechanisms underlying pan-TKI resistance and to identify potential therapeutic targets. We used multiple TKI-resistant HCC cell lines to identify caveolin-1 (CAV1) as a key driver of therapeutic resistance. CAV1 downregulation induced apoptosis, inhibited metastasis and restored TKI sensitivity in both inherent and acquired TKI-resistant HCC cells. Mechanistically, in acquired TKI-resistant cells aberrant CAV1/STAT3/P70S6K signalling is required for their survival, motility, and invasiveness. CAV1 inhibition reduced expression of dormancy regulators E-cadherin, RAC1 and p21, enhanced cancer stemness markers, and …