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2025

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Food Safety Concerns: A Review On Pathogenic Microbes Associated With Common Edible Insects, Anitha Philbert Dec 2025

Food Safety Concerns: A Review On Pathogenic Microbes Associated With Common Edible Insects, Anitha Philbert

Tanzania Journal of Science

This review explored the pathogenic microbes associated with common edible insects. With rising human populations and fluctuating food supplies, edible insects offer a rich source of protein, vitamins, and minerals and are culturally accepted in many regions. Despite their nutritional benefits, knowledge on microbial hazards associated with edible insects is fragmented. The review focuses on commonly consumed species, including Tenebrio molitor, Zophobas morio, Acheta domesticus, Gryllus bimaculatus, Locusta migratoria, Ruspolia differens, Bombix mori, Bunaea alcinoe, and Oryctes monoceros. A total of 43 pathogenic bacteria and 20 pathogenic fungi linked to these edible insect species were identified. The most frequently reported …


Black Bone Mri Morphometry For Mandibular Cortical Bone Measurement In Head And Neck Cancer Patients: Prospective Method Comparison With Ct, Lisanne V Van Dijk, Juan Ventura, Kareem A Wahid, Lin L Zhu, Brigid A Mcdonald, Sara Ahmed, Keith L Sanders, Sonja M Stieb, Lance Mccoy, Christina S Sharafi, Kathryn E Preston, Natalie A West, Sarah Mirbahaeddin, Dina M El-Habashy, Travis Salzillo, Samuel Mulder, Joly Fahim, Aubryane Dearmas, Mona Arbab, Yao Ding, Jihong Wang, Bastien Rigaud, Anando Sen, Mark Chambers, Katherine A Hutcheson, Kristy K Brock, Abdallah S R Mohamed, Stephen Y Lai, Clifton D Fuller Dec 2025

Black Bone Mri Morphometry For Mandibular Cortical Bone Measurement In Head And Neck Cancer Patients: Prospective Method Comparison With Ct, Lisanne V Van Dijk, Juan Ventura, Kareem A Wahid, Lin L Zhu, Brigid A Mcdonald, Sara Ahmed, Keith L Sanders, Sonja M Stieb, Lance Mccoy, Christina S Sharafi, Kathryn E Preston, Natalie A West, Sarah Mirbahaeddin, Dina M El-Habashy, Travis Salzillo, Samuel Mulder, Joly Fahim, Aubryane Dearmas, Mona Arbab, Yao Ding, Jihong Wang, Bastien Rigaud, Anando Sen, Mark Chambers, Katherine A Hutcheson, Kristy K Brock, Abdallah S R Mohamed, Stephen Y Lai, Clifton D Fuller

Faculty, Staff and Student Publications

Objectives: Determine the utility of low-flip angle "black bone" magnetic resonance imaging (MRI) for cortical mandibular bone assessment compared to computed tomography (CT).

Methods: Quantification of cortical mandibular bone width was performed per Hamada et al. at 15 cross-sectional interdentium locations on pretreatment black bone MRI and CT for 15 oropharyngeal cancer patients, with interobserver analyses on a subset of three patients by 11 observers. CT and MRI measurements were compared using Bland-Altman analysis, Lin's concordance, and Deming regression; interobserver variability was assessed with absolute variance and intraclass correlation coefficient (ICC).

Results: Bland Altman and Deming regression analyses showed CT …


Sex Differences In Bile Acid Homeostasis And Excretion Underlie The Disparity In Liver Cancer Incidence Between Males And Females, Megan E Patton, Sherwin Kelekar, Lauren J Taylor, Angela E Dean, Qianying Zuo, Rhishikesh N Thakare, Sung Hwan Lee, Emily C Gentry, Morgan Panitchpakdi, Pieter Dorrestein, Yazen Alnouti, Zeynep Madak-Erdogan, Ju-Seog Lee, Milton J Finegold, Sayeepriyadarshini Anakk Dec 2025

Sex Differences In Bile Acid Homeostasis And Excretion Underlie The Disparity In Liver Cancer Incidence Between Males And Females, Megan E Patton, Sherwin Kelekar, Lauren J Taylor, Angela E Dean, Qianying Zuo, Rhishikesh N Thakare, Sung Hwan Lee, Emily C Gentry, Morgan Panitchpakdi, Pieter Dorrestein, Yazen Alnouti, Zeynep Madak-Erdogan, Ju-Seog Lee, Milton J Finegold, Sayeepriyadarshini Anakk

Faculty, Staff and Student Publications

Hepatocellular carcinoma (HCC), the common liver cancer, exhibits higher incidence in males. Here, we report that mice lacking bile acid (BA) regulators, Farnesoid X Receptor (FXR also termed NR1H4) and Small Heterodimer Partner (SHP also termed NR0B2), recapitulate the sex difference in liver cancer risk. Since few therapeutic options are available, we focused on understanding the intrinsic protection afforded to female livers. Transcriptomic analysis in control and NR1H4 and NR0B2 double knockout livers identified female-specific changes in metabolism, including amino acids, lipids, and steroids. To assess translational relevance, we examined if transcriptomic signatures obtained from this murine HCC model correlate …


Batf2 Is A Glutamine-Responsive Tumour Suppressor Required For Type-I Interferon-Dependent Anti-Tumour Immunity, Wang Gong, Hülya F Taner, Yuesong Wu, Yumin He, Xingwu Zhou, Zaiye Li, Xin Hu, Charisse Ursin, Kala Chand Debnath, Kohei Okuyama, Qiang Hu, Christopher R Donnelly, Felipe Nör, Chamila D Perera, Emily Bellile, Arash Yunesi, Zhiqian Zhai, Mei Zhao, Wanqing Cheng, Zackary R Fitzsimonds, Luke Broses, Jiaqian Li, Shadmehr Demehri, Deepak Nagrath, Gregory T Wolf, Andrew G Sikora, Yanbao Yu, Haitao Wen, Lei Wei, Steven B Chinn, Jeffrey N Myers, Shizuo Akira, Yuying Xie, James J Moon, Yu Leo Lei Dec 2025

Batf2 Is A Glutamine-Responsive Tumour Suppressor Required For Type-I Interferon-Dependent Anti-Tumour Immunity, Wang Gong, Hülya F Taner, Yuesong Wu, Yumin He, Xingwu Zhou, Zaiye Li, Xin Hu, Charisse Ursin, Kala Chand Debnath, Kohei Okuyama, Qiang Hu, Christopher R Donnelly, Felipe Nör, Chamila D Perera, Emily Bellile, Arash Yunesi, Zhiqian Zhai, Mei Zhao, Wanqing Cheng, Zackary R Fitzsimonds, Luke Broses, Jiaqian Li, Shadmehr Demehri, Deepak Nagrath, Gregory T Wolf, Andrew G Sikora, Yanbao Yu, Haitao Wen, Lei Wei, Steven B Chinn, Jeffrey N Myers, Shizuo Akira, Yuying Xie, James J Moon, Yu Leo Lei

Faculty, Staff and Student Publications

Recent evidence highlights the significance of a new type of tumour suppressors, which are not frequently mutated but inhibited by metabolic cues in cancers. Here, we identify BATF2 as a tumour suppressor whose expression is epigenetically silenced by glutamine in Head and Neck Squamous Cell Carcinomas (HNSCC). BATF2 correlates with type-I interferon and Th1 signatures in human HNSCC, with correlation coefficients even stronger than those of the positive control, STING. The phosphorylation of BATF2 at serine 227 promotes the oligomerization of STING. BATF2 deficiency or high glutamine levels result in higher oxygen consumption rates and metabolic profiles unfavorable for …


Incorporating Obstetrical Simulation Into Physician Assistant Didactic Curriculum., Ashley D. Griffin, Nicole K. Daher, Jolene E. Bohensky Dec 2025

Incorporating Obstetrical Simulation Into Physician Assistant Didactic Curriculum., Ashley D. Griffin, Nicole K. Daher, Jolene E. Bohensky

PCOM Scholarly Works

BACKGROUND: Ensuring physician assistant (PA) students are adequately prepared and exposed to women’s health competencies is a requirement for PA programs regulated by Accreditation Review Commission on Education for Physician Assistants (ARC-PA). Over the years, there has been a growing shortage of clinical rotation sites in women’s health, particularly those offering obstetrical experiences. Medical simulation is being suggested as an alternative method to supplement a student’s experience and to bridge knowledge gaps. Program faculty at the Philadelphia College of Osteopathic Medicine Physician Assistant Program developed, implemented, and piloted a simulated vaginal delivery experience performed on high-fidelity manikins for students in …


Non-Invasive Diagnosis Of Pulmonary Tuberculosis Using Face Mask Sampling: A Prospective Study In Adults, Dariusz Woelk, Lennard Meiwes, Nelly Ciobanu, Valeriu Crudu, Anna-Marya Comanac, Stela Kulcitkaia, Anca Vasiliu, Anna Maria Mandalakas, Christoph Lange, Thomas Theo Brehm, Dumitru Chesov Dec 2025

Non-Invasive Diagnosis Of Pulmonary Tuberculosis Using Face Mask Sampling: A Prospective Study In Adults, Dariusz Woelk, Lennard Meiwes, Nelly Ciobanu, Valeriu Crudu, Anna-Marya Comanac, Stela Kulcitkaia, Anca Vasiliu, Anna Maria Mandalakas, Christoph Lange, Thomas Theo Brehm, Dumitru Chesov

Faculty, Staff and Students Publications

Objectives: Sputum-based diagnostic methods for pulmonary tuberculosis (TB), including culture and nucleic acid amplification tests, provide high sensitivity and specificity. However, these methods rely on the patients' ability to produce sputum. In cases where sputum cannot be obtained, invasive procedures like bronchoscopy may become necessary. Our objective was to evaluate the diagnostic accuracy of face mask sampling (FMS) as a non-invasive alternative.

Methods: Adults with microbiologically confirmed pulmonary TB who had received fewer than three days of anti-TB therapy were recruited in Chişinău, Moldova. FMS was conducted and samples were analyzed on-site using Xpert MTB/RIF Ultra. Diagnostic performance was compared …


Communication Factors Influencing Smallholder Farmers' Adoption Of Climate Change Adaptation Measures In Kenya’S Embu County, Olive Wanjiru Ndwiga, Dominic Mutambu, Daniel Manguriu, Monicah Mucheru-Muna Dec 2025

Communication Factors Influencing Smallholder Farmers' Adoption Of Climate Change Adaptation Measures In Kenya’S Embu County, Olive Wanjiru Ndwiga, Dominic Mutambu, Daniel Manguriu, Monicah Mucheru-Muna

Journal of Environmental Science and Sustainable Development

Climate change in Kenya has severely impacted the agricultural sector, affecting food security. It is crucial to enhance farmers’ adaptive capacity to cope with these threats. Effective communication of climate variation risks and coping measures is essential to improve farmers' adaptive capacity. Nevertheless, the adoption of adaptation measures remains low. This is because the influence of communication factors remains underexplored. Therefore, this study focuses on exploring the communication factors affecting the adoption of climate variation adaptation measures in Embu County. The study was conducted in 2023 and 2024 and analysed using the Statistical Package for Social Sciences (SPSS) software. The …


Identifying Research Priorities For Post-Collision Care In The United Kingdom: Protocol For A Road Injury Priority Setting Partnership, Tim Nutbeam, Caroline Leech, Claire E Baker, Elizabeth Box, Lauren R Rodgers, Kerry Dungay, Louise Johnson, Brian Lee, Marilyn Macqueen, Rob Fenwick, Ian Marritt, Ian Dunbar, Ed B.G. Barnard Dec 2025

Identifying Research Priorities For Post-Collision Care In The United Kingdom: Protocol For A Road Injury Priority Setting Partnership, Tim Nutbeam, Caroline Leech, Claire E Baker, Elizabeth Box, Lauren R Rodgers, Kerry Dungay, Louise Johnson, Brian Lee, Marilyn Macqueen, Rob Fenwick, Ian Marritt, Ian Dunbar, Ed B.G. Barnard

Peninsula Medical School

Background: Road traffic injury remains a significant global health challenge, causing over 1.2 million deaths and tens of millions of non-fatal injuries each year. In the United Kingdom (UK), more than 1,600 people died and nearly 30,000 sustained serious injuries on the roads in 2024. While improvements in vehicle design, road infrastructure, emergency response, and road user behaviour have contributed to a sustained reduction in road deaths over recent decades, outcomes for those injured remain variable, and post-collision care has received comparatively less research attention. The Road Injury Chain of Survival framework identifies five interdependent stages where timely, coordinated interventions …


Utilization Review Pada Jaminan Kesehatan Nasional: Implementasi, Tantangan Dan Komponen Essensial, Luh Putu Sinthya Ulandari, Putu Ayu Indrayathi Dec 2025

Utilization Review Pada Jaminan Kesehatan Nasional: Implementasi, Tantangan Dan Komponen Essensial, Luh Putu Sinthya Ulandari, Putu Ayu Indrayathi

Jurnal Ekonomi Kesehatan Indonesia

Indonesia has implemented the National Health Insurance (JKN) program since 2014; however, various forms of fraud continue to be found. According to regulations, BPJS Kesehatan, as the national social security agency, is required to conduct Utilization Review (UR) as an effort to control costs and improve the quality of healthcare services. The effectiveness of UR remains questionable due to several implementation challenges. This study aims to explore the implementation of UR, identify its challenges, and examine the essential components required for its effective implementation. The study was conducted in August 2023 using a qualitative approach through in-depth interviews. Samples were …


Combination Of Prednisolone And Mycophenolate Mofetil For The Treatment Of A Cat With Immune-Mediated Panniculitis: A Case Report, J.H. Kim, M.H. Jeon, Y.S. Kwon, Seulgi Bae Dec 2025

Combination Of Prednisolone And Mycophenolate Mofetil For The Treatment Of A Cat With Immune-Mediated Panniculitis: A Case Report, J.H. Kim, M.H. Jeon, Y.S. Kwon, Seulgi Bae

The Thai Journal of Veterinary Medicine

A 3-year-old domestic shorthair cat presented with severe diffuse skin lacerations and cutaneous nodules with purulent discharge. Primary immune-mediated panniculitis was diagnosed. After surgical excision of the lesions, immunosuppressive therapy with prednisolone and mycophenolate mofetil was initiated. The cutaneous lesions resolved, and no recurrence was observed over a 2-year follow-up period.


Application Of Flexible Endoscopy For Gastrointestinal Foreign Body Removal In A Leopard Gecko (Eublepharis Macularius), Jang-Hee Han, Seung Yoon Ahn, Do Na Lee, Seong Chan Yeon Dec 2025

Application Of Flexible Endoscopy For Gastrointestinal Foreign Body Removal In A Leopard Gecko (Eublepharis Macularius), Jang-Hee Han, Seung Yoon Ahn, Do Na Lee, Seong Chan Yeon

The Thai Journal of Veterinary Medicine

A male captive-bred leopard gecko (Eublepharis macularius) presented with a history of inadvertent ingestion of a rubber tip from forceps during feeding. The foreign body was impalpable on physical examination, while radiographic evaluation confirmed its presence in the stomach. Considering the procedural risks associated with invasive surgical interventions, endoscopic retrieval under general anesthesia was pursued. An initial attempt using a 2.8 mm superfine flexible endoscope with 0.8 mm forceps was unsuccessful due to insufficient stability, which hindered effective navigation to the foreign body. In contrast, a second attempt using a larger 9.2 mm flexible endoscope with 2.3 mm …


Echocardiographic Alterations After Administration Of Azithromycin In Donkeys: An Experimental Crossover Study, Mohamed Marzok, Maged El-Ashker, Mahmoud Kandeel, Adel Almubarak, Khalid Alkhodair, Alshimaa Farag, Hussam Ibrahim, Sabry El-Khodery, Hussein Babiker Dec 2025

Echocardiographic Alterations After Administration Of Azithromycin In Donkeys: An Experimental Crossover Study, Mohamed Marzok, Maged El-Ashker, Mahmoud Kandeel, Adel Almubarak, Khalid Alkhodair, Alshimaa Farag, Hussam Ibrahim, Sabry El-Khodery, Hussein Babiker

The Thai Journal of Veterinary Medicine

Cardiotoxicity and impairment of cardiac function are mostly diagnosed by echocardiography and based on objective metrics of cardiac function. The aim of the present study is to investigate the effect of azithromycin on the echocardiographic characteristics in healthy donkeys. Ten healthy donkeys were enrolled in a prospective crossover study. The study included two groups: (1) a placebo (normal saline, NaCl 0.9%), and (2) azithromycin (at a dose of 5 mg/kg body weight). A 2.0-3.9 MHz phased-array transducer was used for echocardiographic examination. Echocardiographic examinations were performed for donkeys before treatment (T0) and at 15, 30, 60, 90, 120, 180, and …


Feline Conjunctivitis In Sleman Region Indonesia: Clinical Characteristics, Bacteriological Isolation Of Staphylococcus Aureus, And Antimicrobial Susceptibility, Agung Budi Pramono, Fatkhanudin Aziz, Faiz Ihsanul Kamil, Soedarmanto Indarjulianto, Ida Tjahajati Dec 2025

Feline Conjunctivitis In Sleman Region Indonesia: Clinical Characteristics, Bacteriological Isolation Of Staphylococcus Aureus, And Antimicrobial Susceptibility, Agung Budi Pramono, Fatkhanudin Aziz, Faiz Ihsanul Kamil, Soedarmanto Indarjulianto, Ida Tjahajati

The Thai Journal of Veterinary Medicine

Conjunctivitis is a common ocular condition in domestic cats, often associated with Staphylococcus aureus. Accurate detection and resistance profiling are essential for appropriate therapy. This study aimed to characterize clinical features of feline conjunctivitis, identify S. aureus using phenotypic and genotypic methods, and assess its antibiotic susceptibility. Twenty conjunctivitis-suspected cats in Sleman, Indonesia, underwent clinical examination and conjunctival swabbing. Bacterial isolates were cultured on Mannitol Salt Agar and identified by Gram stain, catalase, coagulase, biochemical tests, and PCR targeting 23S rRNA. Susceptibility to gentamicin, chloramphenicol, ciprofloxacin, and amoxicillin was tested by Kirby-Bauer. Predominant signs included excessive tearing (95%), hyperemia …


Theorizing ‘Magwangala’ As An Unorthodox Livelihood In Geita, Tanzania, Albert Tibaijuka Dec 2025

Theorizing ‘Magwangala’ As An Unorthodox Livelihood In Geita, Tanzania, Albert Tibaijuka

Tanzania Journal of Sociology

The increasing contestation of Magwangala as a livelihood in Geita, Tanzania, invokes a scholarly desire to further the constitution of the term beyond its traditional constructs. Following the present framing of magwangala as a disruptive, hazardous, contentious, and risky engagement; including the sanctions against it and the disparaging remarks upsurging the oppression of its actors, an attempt to advance its comprehension is of paramount importance. Given the nature of Magwangala business and the evident ramifications, its contestation is inevitable and unlikely to yield a uniform understanding. This paper, therefore, draws from the grueling life experiences endured by magwangala dealers in …


Patient And Systemic Barriers To Cancer Care: Implications For Delayed Prostate Cancer Detection In Tanzania, Jane Senga John Dec 2025

Patient And Systemic Barriers To Cancer Care: Implications For Delayed Prostate Cancer Detection In Tanzania, Jane Senga John

Tanzania Journal of Sociology

Prostate cancer is a leading cause of cancer-related mortality among men in Tanzania, with most cases diagnosed at advanced stages. This study explores the interplay of patient-level and systemic barriers that contribute to delayed prostate cancer detection within a tertiary hospital context. Conducted at Bugando Medical Centre in Mwanza, the research employed in-depth interviews with 25 purposefully selected participants, including patients, oncologists, spouses and traditional healers. Thematic analysis was used and guided by Paul Farmer’s structural violence model and Courtenay’s theory of gender and health to interpret how cultural, economic, and structural factors shape health-seeking behaviours. Findings reveal that delays …


Influence Of Household Characteristics And Incident Setting On Child Abuse Cases In Shinyanga Region., Amani Mapamba Dec 2025

Influence Of Household Characteristics And Incident Setting On Child Abuse Cases In Shinyanga Region., Amani Mapamba

Tanzania Journal of Sociology

This study investigates the influence of household characteristics and incident settings on child abuse cases in Shinyanga Region, Tanzania. Grounded in Rational Choice Theory, the study assumes that perpetrators make calculated decisions influenced by household structure and contextual settings. Utilizing a quantitative research approach, cross sectional secondary data were collected from 401 reported child abuse cases at Shinyanga Regional Referral Hospital between July 2020 and April 2023. Binary logistic regression was used to analyze the predictive influence of variables such as relationship to household head, history of abuse in the household, perpetrator identity, and location of the incident. Findings revealed …


Effects Of Corporal Punishments On Students’ Learning: A Case Of Selected Secondary Schools In Tanzania., Adenias Ishabisa Dec 2025

Effects Of Corporal Punishments On Students’ Learning: A Case Of Selected Secondary Schools In Tanzania., Adenias Ishabisa

Tanzania Journal of Sociology

The paper presents the practice of corporal punishment on students’ learning in Tanzania secondary schools. Specifically, the study examine how corporal punishment affects students’ learning. The study adopted a qualitative research approach with multiple embedded case study design. Data were collected from 76 participants selected purposefully from Morogoro Municipal, Mvomero District, Sumbawanga Municipal, and Nkasi District. The participants were students, teachers, Regional Educational Officers, District Secondary Educational Officers, and school board members. In-depth interviews, focus group discussions, observation, and documentary reviews were applied to collect data while thematic analysis was used to address the research question. The findings revealed that …


Electrochemical Characterization And Modulation Of Biological Processes, Yue-Qi Li, Wei-Hua Huang, De-Chen Jiang, Bao-Hong Liu, Bin Su, Yang Tian, Jing-Juan Xu, Ping Yu, Feng Zhao, Huang-Xian Ju, Jing-Hong Li Dec 2025

Electrochemical Characterization And Modulation Of Biological Processes, Yue-Qi Li, Wei-Hua Huang, De-Chen Jiang, Bao-Hong Liu, Bin Su, Yang Tian, Jing-Juan Xu, Ping Yu, Feng Zhao, Huang-Xian Ju, Jing-Hong Li

Journal of Electrochemistry

Electrochemical processes lie at the core of biological function, governing energy transduction, metabolic flux, and molecular signaling. Recent advances in electrochemical science now allow these processes to be probed and controlled with unprecedented spatial, temporal, and chemical resolution. In this review, we present an integrated framework that progresses from fundamental mechanisms to analytical technologies and functional modulation. We begin by outlining electron transfer pathways in mitochondrial respiration, microbial extracellular electron transfer, and DNA- and protein-based charge conduction, followed by the principles of photon-electron conversion in photosynthesis and the central role of redox equilibrium in coordinating cellular responses. We then highlight …


State Of California Cannabis Reporting, University Of Mississippi – National Center For Cannabis Research And Education Dec 2025

State Of California Cannabis Reporting, University Of Mississippi – National Center For Cannabis Research And Education

California

No abstract provided.


Empirical Analysis Of Machine Learning Models For Predicting Equipment Failures Using Iot Sensor Data, Yusuf Shodiyevich Avazov Dec 2025

Empirical Analysis Of Machine Learning Models For Predicting Equipment Failures Using Iot Sensor Data, Yusuf Shodiyevich Avazov

Chemical Technology, Control and Management

This article examines the problem of detecting and predicting industrial equipment faults using IoT sensor data through machine learning techniques. Sensor readings such as temperature, vibration, pressure, voltage, and current, as well as FFT-based features, were statistically analyzed. Class imbalance and low signal informativeness were identified as key factors limiting model accuracy. Results obtained from Logistic Regression, Random Forest, and XGBoost models were comparatively evaluated, showing that when ROC-AUC values remain around 0.5, distinguishing fault and non-fault states becomes challenging. Correlation and feature-importance analyses confirmed the absence of strong dominant indicators. The findings highlight the need to improve sensor architecture …


A Pouch Of Trouble For The Pancreas: Unmasking A Case Of Lemmel Syndrome, Aravindharaj Tamilselvan, Sabari Ramesh Dec 2025

A Pouch Of Trouble For The Pancreas: Unmasking A Case Of Lemmel Syndrome, Aravindharaj Tamilselvan, Sabari Ramesh

Manipal Journal of Medical Sciences

Lemmel syndrome is a rare cause of biliary and pancreatic obstruction arising from periampullary duodenal diverticula. We report a 72-year-old woman presenting with acute pancreatitis, biliary dilation, and a periampullary diverticulum causing distal CBD compression. Multimodality imaging, including CT and MRCP, established the diagnosis. Although ERCP was advised, the patient declined and improved with conservative management. Early recognition of this uncommon entity is essential to prevent recurrent pancreatobiliary complications.


Exploring Cellular Heterogeneity: Single-Cell And Spatial Transcriptomics Of Alzheimer's Disease Brains And Ipsc-Derived Microglia, Anjali Garg, Sheeny Vo, Iara D De Souza, Ayslan Castro Brant, Logan Brase, Ekaterina Aladyeva, Ricardo D 'O Albanus, Aasritha Nallapu, Hongjun Fu, Oscar Harari Dec 2025

Exploring Cellular Heterogeneity: Single-Cell And Spatial Transcriptomics Of Alzheimer's Disease Brains And Ipsc-Derived Microglia, Anjali Garg, Sheeny Vo, Iara D De Souza, Ayslan Castro Brant, Logan Brase, Ekaterina Aladyeva, Ricardo D 'O Albanus, Aasritha Nallapu, Hongjun Fu, Oscar Harari

2020-Current year OA Pubs

BACKGROUND: Microglia, the brain’s resident immune cells, play a pivotal role in Alzheimer’s disease (AD) pathogenesis. These cells exhibit diverse transcriptional states in response to neuroinflammatory stimuli, and characterizing these states is essential for understanding AD mechanisms. METHODS: We integrated single-cell and spatial transcriptomic datasets from multiple cohorts and brain regions, encompassing both experimental models and human tissues. Findings were validated through immunostaining of human brain samples. RESULTS: Our comprehensive atlas revealed pronounced heterogeneity among microglial states, with disease-associated microglia (DAM) significantly enriched in AD brains compared to controls. Spatial transcriptomics and immunohistochemistry demonstrated that DAM predominantly localize to external …


Regenerative And Wellness Medicine: A Boon Or Barrier To Surgical Innovation In Degenerative Spine Care?, Álvaro Dowling, Kai-Uwe Lewandrowski, Morgan P. Lorio, Óscar L. Alves, Rossano Kepler Alvim Fiorelli, Sergio Luis Schmidt, Hansen A. Yuan, Alexander R. Vaccaro Dec 2025

Regenerative And Wellness Medicine: A Boon Or Barrier To Surgical Innovation In Degenerative Spine Care?, Álvaro Dowling, Kai-Uwe Lewandrowski, Morgan P. Lorio, Óscar L. Alves, Rossano Kepler Alvim Fiorelli, Sergio Luis Schmidt, Hansen A. Yuan, Alexander R. Vaccaro

Department of Orthopaedic Surgery Faculty Papers

BACKGROUND: Regenerative and wellness medicine is rapidly reshaping health care, particularly in the management of degenerative spine conditions. Noninvasive or minimally invasive options such as stem cell therapy, platelet-rich plasma (PRP) injections, and holistic wellness programs are increasingly selected by patients who wish to avoid the risks, costs, and prolonged recovery associated with elective spine surgery.

PURPOSE: This perspective article examines whether regenerative and wellness approaches function primarily as a boon or a barrier to innovation in spine surgery and explores their impact on traditional, insurance-based surgical care models.

METHODS: Using a narrative, opinion-based framework, this article synthesizes current trends …


Role Of Gut Microbiome In Oncogenesis And Oncotherapies, Renuka Sri Sai Peddireddi, Sai Kiran Kuchana, Rohith Kode, Saketh Khammammettu, Aishwarya Koppanatham, Supriya Mattigiri, Harshavardhan Gobburi, Suresh K. Alahari Dec 2025

Role Of Gut Microbiome In Oncogenesis And Oncotherapies, Renuka Sri Sai Peddireddi, Sai Kiran Kuchana, Rohith Kode, Saketh Khammammettu, Aishwarya Koppanatham, Supriya Mattigiri, Harshavardhan Gobburi, Suresh K. Alahari

School of Graduate Studies Faculty Publications

The gut microbiome has emerged as a key regulator of human health, influencing not only metabolism and immunity but also the development and treatment of cancer. Mounting evidence suggests that microbial dysbiosis contributes to oncogenesis by driving chronic inflammation, producing genotoxic metabolites, altering bile acid metabolism, and disrupting epithelial barrier integrity. At the same time, the gut microbiome significantly modulates the host response to oncotherapies including chemotherapy, radiotherapy, and especially immunotherapy, where microbial diversity and specific taxa determine treatment efficacy and toxicity. This review synthesizes current evidence on the role of the gut microbiome in both oncogenesis and oncotherapies, focusing …


Metabolic Syndrome As A Risk Factor For Postoperative Complication In Patients Undergoing Spine Surgery: A Systematic Review And Meta-Analysis Of More Than 3 Million Cases, Amir-Mohammad Asgari, Farhad Shaker, Mohammad Taha Pahlevan Fallahy, Sourena Sharifkashani, Alireza Soltani Khaboushan, Dorsa Salabat, César Carballo Cuello, James Harrop, Puya Alikhani Dec 2025

Metabolic Syndrome As A Risk Factor For Postoperative Complication In Patients Undergoing Spine Surgery: A Systematic Review And Meta-Analysis Of More Than 3 Million Cases, Amir-Mohammad Asgari, Farhad Shaker, Mohammad Taha Pahlevan Fallahy, Sourena Sharifkashani, Alireza Soltani Khaboushan, Dorsa Salabat, César Carballo Cuello, James Harrop, Puya Alikhani

Department of Neurosurgery Faculty Papers

OBJECTIVE: Including conditions like obesity, diabetes, hypertension, and dyslipidemia, metabolic syndrome disrupts metabolic homeostasis and impairs recovery, increasing the risk of surgical complications. This study evaluates the impact of metabolic syndrome on spine surgery outcomes, addressing inconsistencies in the existing literature.

METHODS: Four databases were searched until December 2024 for studies comparing the postoperative complication rates of spine surgeries between patients with and without metabolic syndrome. Following deduplication, 2 authors independently reviewed the studies. For each included study, demographics and incidence rates of postoperative complications were extracted separately by 2 authors. Data analysis was performed using R.

RESULTS: After deduplication, …


Radiographic Assessment Of Anterior Maxillary Sites Prior To Immediate Implant Placement: A Retrospective Study On Cbct, Elissa El Alam, Abdallah Menhall, Nabil Ghosn, Pierre Lahoud Dec 2025

Radiographic Assessment Of Anterior Maxillary Sites Prior To Immediate Implant Placement: A Retrospective Study On Cbct, Elissa El Alam, Abdallah Menhall, Nabil Ghosn, Pierre Lahoud

International Arab Journal of Dentistry

Objectives: The purpose of this retrospective radiographic study was to measure alveolar bone width at the alveolar crest, intraosseous root length, apical bucco-palatal bone thickness and apical bone height at the anterior maxillary teeth prior to immediate implant placement. Dehiscence and fenestration at these sites were also reported.

Methods: 50 CBCTs were included in this study. Measurements were taken on the right and left sides of the central incisor, lateral incisor, and canine using a 3d slicer program. Frequency of fenestration and dehiscence at these sites were also reported.

Results: Mean bone width at the alveolar crest of the central …


The Assessment Of Ageism In Dental Hygiene Students And Dental Hygienists: A Cross-Sectional Study, Paolo Boffano, Elena Canciani, Valeria Nikolovska, Francesca Santeusanio, Andrea Melle Dec 2025

The Assessment Of Ageism In Dental Hygiene Students And Dental Hygienists: A Cross-Sectional Study, Paolo Boffano, Elena Canciani, Valeria Nikolovska, Francesca Santeusanio, Andrea Melle

International Arab Journal of Dentistry

Objectives: Ageism is a common type of discrimination and prejudice that consists in the stereotyping and discrimination against individuals or groups on the basis of their age.The purpose of this study was to assess dental hygienists and dental hygiene students’ attitudes toward geriatric patients, the perceptions of curriculum suitability, and their confidence in treating geriatric patients, together with an assessment of ageism in the study population.

Methods: A survey was conducted among dental hygienists and dental hygiene students. The first part of the questionnaire contained questions related to demographics, and regarding their opinion on treatment in the geriatric population. The …


Comparative Evaluation Of The Solubility Of Three Commonly Used Root Canal Sealers When Exposed To Xylene And Endosolv: An In Vitro Study, Aparna Palekar, Piyush Mantri, Basawaraj Biradar, Mukund Singh, Vaidehi Joshi, Pushpal Ingle Dec 2025

Comparative Evaluation Of The Solubility Of Three Commonly Used Root Canal Sealers When Exposed To Xylene And Endosolv: An In Vitro Study, Aparna Palekar, Piyush Mantri, Basawaraj Biradar, Mukund Singh, Vaidehi Joshi, Pushpal Ingle

International Arab Journal of Dentistry

Objectives: This in vitro study compared the solubility of three root canal sealers, AH Plus (epoxy resin-based), MTA Fillapex (MTA-based), and Cerafill RCS (bioceramic), in two solvents: Xylene and Endosolv.

Methods: Sixty standardized cylindrical specimens were prepared using the three sealers of interest. The specimens were divided into six groups (n = 10) and immersed in either Xylene or Endosolv for 10 minutes. Solubility was assessed by calculating the percentage weight loss before and after immersion. Data were analysed using one-way ANOVA and Tukey’s post hoc test (α= 0.05).

Results: All sealers exhibited statistically significant solubility in both solvents (p …


Three-Dimensional Evaluation Of Torque Expression In Maxillary Incisors: Influence Of Crown Shape And Collum Angle, Isha Singh, Achint Juneja, Divya Shetty, Monis Raza, Payal Sharma, Udit Chaudhary Dec 2025

Three-Dimensional Evaluation Of Torque Expression In Maxillary Incisors: Influence Of Crown Shape And Collum Angle, Isha Singh, Achint Juneja, Divya Shetty, Monis Raza, Payal Sharma, Udit Chaudhary

International Arab Journal of Dentistry

Objectives: To evaluate the influence of crown morphology and collum angle of maxillary incisors on torque expression at common bracket-bonding landmarks using cone-beam computed tomography (CBCT).

Methods: Twenty CBCT scans of individuals aged 18–27 years were analyzed. For each central and lateral incisor, the height of maximum labial contour (HMC), height of the labial anatomic (LA) point, collum angle (CA), and alpha angle at both HMC (αc) and LA (αLA) were measured. Stone casts confirmed LA points. Independent and paired t-tests assessed inter- and intra-tooth differences (α = 0.05).

Results: The HMC was located 2.6 ± 0.3 mm (centrals) and …


Effect Of Red Wine Immersion On The Flexural Strength Of Glass Ionomer Cement: An In Vitro Study, Niyola Crasta, Upasana Reddy, Jayaprakash Kukkila Dec 2025

Effect Of Red Wine Immersion On The Flexural Strength Of Glass Ionomer Cement: An In Vitro Study, Niyola Crasta, Upasana Reddy, Jayaprakash Kukkila

International Arab Journal of Dentistry

Background: Alcoholic beverages such as red wine are widely consumed for social and cultural reasons. Ethanol and other constituents in red wine might alter the physical properties of dental restorative materials, particularly those exposed in the oral environment. Glass ionomer cements (GICs) are commonly used in restorative dentistry for their beneficial properties, but their mechanical strength under exposure to acidic or alcoholic solutions is a concern.

Objectives: To evaluate how exposure to red wine over time affects the flexural strength of glass ionomer cement (Shofu FX Ultra Mini).

Methods: Thirty rectangular specimens of glass ionomer cement (Shofu FX Ultra Mini), …