Digital Commons Network^™

Study On The Role Of Shenfu Injection In Mediating Ferroptosis Through The Akt/Gsk-3Β/Nrf2 Pathway In Yang-Deficient Chronic Heart Failure, Xiaojie Chen, Jiayun Guo, Bing Lin, Huamin Wang, Ziyu Lu, Bayi Liu

Turkish Journal of Biology

Background/aim: The present study investigates the role of Shenfu injection in the treatment of yang-deficient chronic heart failure (CHF). Materials and methods: Sprague-Dawley (SD) rats were modeled for yang-deficient CHF by abdominal aortic coarctation. Echocardiography was performed to detect changes in cardiac function, and serum N-terminal B-type natriuretic peptide proteins (NT-proBNP), cardiac troponin I (cTnI), and ferroptosis-related factors were measured using ELISA kits. Pathological changes in cardiac tissues were observed through hematoxylin-eosin (HE) and Masson’ trichrome staining, cardiomyocyte apoptosis was measured by TUNEL staining, and reactive oxygen species (ROS) production was determined through dihydroethidium (DHE) staining. The expression of nuclear …

Identification Of Epigenetic Monotherapy Candidates In Taxane-Resistant Crpc, Buse Cevatemre, İpek Bulut, Ezgi̇ Karyemez, Ceyda Açilan

Turkish Journal of Biology

Background/aim: Taxane resistance remains a significant challenge in the effective treatment of castration-resistant prostate cancer (CRPC). Given the association of epigenetic regulation with chemotherapy resistance and cancer progression, this study aims to identify epigenetic vulnerabilities in two CRPC cell lines (DU145 and 22Rv1) established as resistant to two different taxanes, docetaxel (Dtx) and cabazitaxel (Cbz), using a small-molecule screening approach. Materials and methods: A small-molecule library targeting epigenetic regulators, including histone deacetylases (HDAC), histone methyltransferases, histone demethylases, bromodomain proteins, deoxyribonucleic acid methyltransferases, protein arginine deiminase, and histone acetyltransferase was utilized. Drug screening was performed on parental and taxane-resistant CRPC cell …

In Vitro Antibiofilm Activity Of Tyrosol Against Single And Dual-Species Biofilms Of Candida Tropicalis And Streptococcus Mutans, Zarifeh Adampour, Betül Yilmaz Öztürk, Bükay Yeni̇ce Gürsu, İlknur Dağ

Turkish Journal of Biology

Background/aim: The cross-kingdom biofilm structure formed by Candida tropicalis and Streptococcus mutans may increase caries formation. The aim of this study was to evaluate the in vitro effect of the exogenous tyrosol on single- and dual-species biofilms as well as planktonic cultures formed by C. tropicalis and S. mutans. Materials and methods: The antimicrobial efficacy of tyrosol was evaluated through broth microdilution, colony-forming unit (CFU) enumeration, and XTT reduction tests to assess cell viability and metabolic activity. Transmission electron microscopy (TEM) was used to examine ultrastructural changes in planktonic cells. Biofilm dynamics were visualized via scanning electron microscopy (SEM) and …

Exploring Shootin1’S Oncogenic Role Within Fgfr2 Gene Fusions, Volkan Ergi̇n, Mutlu Erdoğan, Ekrem Yaşar, Sika Zheng

Turkish Journal of Biology

Background/aim: Fibroblast Growth Factor Receptor (FGFR) gene fusions are recognized as pivotal oncogenic drivers, contributing to cancer initiation and progression across diverse malignancies. These fusions often represent significant therapeutic targets, particularly in challenging malignancies like cholangiocarcinoma. This study aimed to characterize the novel FGFR2::SHTN1 fusion, identify it as a de novo chimeric protein, and elucidate its precise oncogenic mechanism. Materials and methods: FGFR2::SHTN1 fusions were identified via cancer genomics databases and modeled using AlphaFold and HADDOCK. SHTN1 variants were expressed in Neuro-2a cells for coimmunoprecipitation, purification, and native polyacrylamide gel electrophoresis to assess oligomerization. Structural modeling included membrane embedding with …

Efflux Pump-Associated Antimicrobial Resistance Genes In Staphylococcus Spp. From Dairy And Meat Samples, M.Burcu Külahci, Sumru Çitak

Turkish Journal of Biology

Background/aim: This study aimed to investigate the phenotypic resistance and distribution of efflux pump-associated antimicrobial resistance genes in Staphylococcus spp. isolated from dairy and meat samples. Antimicrobial resistance in foodborne bacteria increases with antibiotic exposure and biocides, particularly through efflux mechanisms. Thus, monitoring potential genetic reservoirs in the food chain is very important. Materials and methods: A total of 132 dairy and meat samples were collected for the study, and Staphylococcus spp. were isolated using Mannitol salt phenol red agar. Antimicrobial susceptibility was evaluated using the Clinical and Laboratory Standards Institute’s microdilution method. Twenty-six resistant isolates were identified by 16S …

Strengthening Homoeopathy With Standards: The Bis Initiative, Raj K Manchanda, Kumar Vivekanand, Daisy Katarmal

Indian Journal of Research in Homoeopathy

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6c Potency Of Terminalia Chebula Reveals Secondary Metabolites And Induces Apoptosis In Triple-Negative Breast Cancer Cells (Tnbcs), Apoorva Parimoo, Shama Aphale, Prajakta D. Patil, Ruchika Kaul Ghanekar

Indian Journal of Research in Homoeopathy

Background: Breast cancer is a prevalent malignancy in women globally, and TNBCs, being ER-/PR-/Her2-, pose challenges in treatment options. Complementary and alternative medicines, including homoeopathic remedies, have gained popularity as potential anti-cancer agents to mitigate the side e ects of conventional drugs. Previously, the anticancer activity of homoeopathic potencies of Terminalia chebula (MT, 3X, 6C, and 30C) against breast cancer cell lines has been reported. Objectives: This study aimed to evaluate the mechanism of anticancer activity of 6C potency of T. chebula against the TNBC cell line, MDAMB231 and to understand the phytochemical composition of 6C potency. Methods: …

Homoeopathic Intervention In Dual Autoimmune Disorders: A Case Report On Management Of Vitiligo And Hashimoto Thyroiditis, Nitin Kumar Saklani

Indian Journal of Research in Homoeopathy

Background: Vitiligo and Hashimoto Thyroiditis often occur as chronic autoimmune disorders that require careful evaluation and individualised management. This case study examines the usefulness of homoeopathic interventions in addressing the complexities of Vitiligo and Hashimoto Thyroiditis through evidence-based methodologies. Case Summary: A 57-year-old woman initially sought medical attention for a noticeable whitish discolouration on the left side of her lips. Subsequent evaluations unveiled the presence of hypothyroidism, marked by elevated Anti-TPO levels, exposing the dual autoimmune nature of her condition. The patient’s concerns centered on the aesthetic impact of vitiligo on her lips and the broader health implications …

Homoeopathy During One Hundred Years Of Lmhi (1925–2025)– Part 1: Philosophical Perspectives, Josef M. Schmidt

Indian Journal of Research in Homoeopathy

The celebration of 100 years of “Liga medicorum homoeopathica internationalis” (LMHI) in 2025 gives reason to reflect on the philosophical essence of Homoeopathy as well as its historical development within a dynamic, changing world up to now.

From a philosophical perspective, in this first part, it is pointed out that Hahnemann, the founder of Homoeopathy, needs to be understood in his entirety– not only as a keen discoverer, practitioner and thinker, but also in his spiritual shape, i.e. in his ethical, religious and humanitarian attitude and conviction.

Only thus may one grasp the significance of the schism pervading Homoeopathy’s history …

A Workshop On Systematic Review And Meta-Analysis: Ccrh's Capacity Building Initiative For Evidence Synthesis, Surbhi Jain, Harleen Kaur, Purnima Rani, Gurpreet Singh, Shalini Rao, Akansha Harit, Shivam Shivam, K. C. Muraleedharan, Sunil S. Ramteke, Subhash Kaushik

Indian Journal of Research in Homoeopathy

The workshop on `Systematic Review and Meta-Analysis for Beginners: A Practical Introduction' was organised by Central Council for Research in Homoeopathy (CCRH) in hybrid mode on 13^th and 14^thAugust 2025 at the auditorium of the Ayush building in New Delhi, India. The workshop with 8 technical sessions conducted over a span of 2 days, was attended by more than 400 delegates across various units/institutes of CCRH. The aim was to build capacity of scientists/ researchers of CCRH about the conduct of systematic reviews and meta- analyses, as they represent the highest level in the hierarchy of scientific …

Acknowledgement To Our Reviewers (2025), Ijrh Editorial Board

Indian Journal of Research in Homoeopathy

The following experts are sincerely acknowledged for their invaluable inputs, while reviewing the manuscripts for the Indian Journal of Research in Homoeopathy in 2025. Their timely inputs enabled a fair and rigorous peer-review process, and we are immensely thankful for the same.

Closing Issue Of 2025, Subhash Kaushik

Indian Journal of Research in Homoeopathy

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Physicochemical, Pharmacognostic Standardisation And Phytochemical Analyses Of The Homoeopathic Drug Justicia Adhatoda, Bibaswan Biswas, Satish Patel, Digvijay Verma, Satyajit Maity, Shilpi Singh, Paulami Majumdar, Narasimha Kumar Gv

Indian Journal of Research in Homoeopathy

Background: Justicia adhatoda (J. adhatoda), also well known as Vasaka in India is a medicinal plant chiefly used to treat respiratory ailments in traditional and alternative medical systems. Objective: This study aimed to establish the physicochemical, pharmacognostic, and phytochemical standardisation parameters of the drug. The study involved the measurement of physicochemical parameters and chemical profiling of the raw drug. The chemical characteristics of the in-house mother tincture (prepared from in-house raw drug) and commercial mother tinctures available in India were also evaluated to assess the quality of commercially available mother tinctures. Materials and Methods: The present study …

Potency Dependent Angiogenic Effect Of Bellis Perennis On In Ovo Chick Chorioallantoic Membrane Assay, Jayanthdevan V, Winston Vargheese V, Anish Fathima K, Lohita S

Indian Journal of Research in Homoeopathy

Background: Hormesis is the biological response of an organism for a particular dosage of a substance. The lower dose stimulates and higher dose inhibits. J Compton Burnett, an eminent homeopath, prescribed Bellis perennis for breast and uterine tumours, which suggests it could be due to the antiangiogenic property or angiogenic inhibiting property and clinically also it is used for healing of fractured bone and wound healing which may be due to angiogenic promoting property. This experiment deals with the dose dependent effect of Bellis perennis on In Ovo Chick Chorioallantoic Membrane Assay. Objective: To evaluate the Hormesis effect of Bellis …

Indian Standard For Globules Used In Homoeopathy, Kumar Vivekanand, Daisy Katarmal, Indra Gaurav Saxena, Divya Taneja, Shrishti Dixit, Raj Kumar Manchanda

Indian Journal of Research in Homoeopathy

This article aims to describe and critically examine the Indian Standard (IS 18947:2024) for globules used in Homoeopathy, outlining the technical specifications, testing methods, and significance for pharmaceutical quality assurance. The implications of the standard for manufacturers, quality control laboratories, consumers and regulatory bodies engaged in the production and evaluation of homoeopathic drugs are highlighted by presenting a consolidated view of the standard's scope and applications. This discussion underscores the continued importance of systematic standardization in ensuring the safety, consistency, and global credibility of homoeopathic medicinal products produced in India.

Research Highlights, Kusum Lata, Ekta Agrawal

Indian Journal of Research in Homoeopathy

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Book Review: Victim-Centred Peacemaking: Colombia’S Santos–Farc-Ep Peace Process, Patricia M. Rodriguez

Genocide Studies and Prevention: An International Journal

No abstract provided.

Concentric Macular Rings And Oct Corrugations In Foveal Hypoplasia: Proof Of Concept For An Optical Interference Mechanism, Ari August, Ralph Eagle, Tatyana Milman, Rebecca Procopio, Bruce Schnall, Jose Pulido

Wills Eye Hospital Papers

BACKGROUND: Concentric macular rings (CMR) and Henle fiber layer (HFL) corrugations, potential clinical biomarkers of foveal hypoplasia, have been observed in laser fundus photographs and optical coherence tomography (OCT) images, respectively. Some believe these findings represent true anatomical structural changes while others hypothesize that they are artifacts of interference; however, to our knowledge, no previous study has provided evidence to support either theory.

METHODS: This retrospective case series analyzed CMR and OCT corrugations in 3 patients (6 eyes) with foveal hypoplasia. Dark fringe diameters of CMR at different wavelengths (λ: red = 635, green = 532, blue = 488 nm) …

Perspectives On Implementing Environmentally Sustainable Practices In Cataract Surgeries: Interviews Of Administrative And Frontline Healthcare Workers, Daniel Parra, Brooke Sherry, Emma Pak, Lauren Taylor, Erin S. Rogers, Sarah E. Hochman, Maria De Los Angeles Ramos Cadena, Joel S. Schuman, Christina R. Prescott, Cassandra L. Thiel

Wills Eye Hospital Papers

BACKGROUND: Healthcare is responsible for 8.5% of greenhouse gas emission in the United States. Physicians are becoming increasingly concerned about the climate crisis, particularly in the field of ophthalmology where there is a growing body of literature related to sustainability. Although emissions of cataracts surgery, one of the most performed surgical procedures in the world, have been quantified, modifications to practice have yet to be made. This study aims to uplift the perspectives of a diverse set of healthcare workers on implementing environmentally sustainable practices in the cataract surgery setting.

METHODS: 16 semi-structured interviews were conducted with professionals working in …

Effect Of Stages Of Prehospital Hypertensive Crisis And Length-Of-Stay On Acute Stroke Readmission, Thomas Bob Ross Phd

Walden Dissertations and Doctoral Studies

Stroke is the second leading cause of mortality and the third leading cause of disability, affecting over 800,000 Americans annually. Traditional stroke research has focused on in-hospital settings, but not on prehospital stroke admissions, despite evidence that over 75% of acute stroke cases managed by emergency medical services involve prehospital hypertensive crises (HTN-C). HTN-C is classified into three systolic blood pressure (SBP) stages: Stage 1 (140–159 mm Hg), Stage 2 (160–179 mm Hg), and Stage 3 (≥180 mm Hg), the latter associated with organ damage. Hypertension correlates with longer hospital stays and more intensive interventions in hospitalized patients, but HTN-C …

The Art And Science Of Healing: Reframing The Healer's Mindset For The Human-Ai Era, Jen-Hung Yang

Journal of Medical Education

Background: AI's expansion in medicine sharpens the tension between diagnostic science and the art of healing. AI is a complex sociotechnical system. Its integration in medicine is accelerating, yet reactive and tool-driven, which offers both opportunities and risks. AI will potentially worsen depersonalization and burnout. Objectives: The aim is to develop the guiding principles of AI to strengthen the art healing in medical education. Innovations: Healer's Mindset, inspired by Gardner's Five Minds, reframes Respectful and Ethical minds as three pillars: critical validation, a humanistic core, and discerning augmentation. These principles can help AI restore medicine's essence: fostering inquiry, faculty …

Choosing Who To Be: Teaching Ethics Through Value Conflicts And Identity Reflection, Jennifer Kwon, Hsingchi Von Bergmann

Journal of Medical Education

Background: This study introduces a reflective learning approach that combines ethical dilemmas with axiological analysis to explore how students' value hierarchies shape their professional identity formation. Moving beyond traditional frameworks such as Principlism, this approach invites learners to examine the tensions between personal and professional values, encouraging critical reflection on how their decisions relate to multiple identities and evolving professional commitments. Methods: Two open-ended ethical dilemmas were distributed via an anonymous online survey using Qualtrics. This method was intentionally chosen to elicit narrative responses from a large cohort of students while providing space for candid reflection on complex, value-laden situations. …

Evaluating Self-Efficacy In Pharm.D. And B.S. Pharmacy Programs: A Repeated Cross-Sectional Study, Jia-An Hung, Kuan-Lin Chen, Yen-Ming Huang, Li-Jiuan Shen, Fei-Yuan Hsiao, Chia-Yi Wu, Fe-Lin Lin Wu, Chi-Chuan Yeh, Shu-Wen Lin

Journal of Medical Education

Background: Pharmacy education in Taiwan has shifted from a four-year Bachelor of Science (B.S.) degree to a six-year Doctor of Pharmacy (Pharm.D.) degree emphasizing patient-centered competencies. This study evaluated the self-efficacy of pharmacy students at different stages of the programs. Methods: A repeated cross-sectional survey was conducted from 2017 to 2019 at a university in Taiwan. Third- to sixth-year Pharm.D. and fourth-year B.S. students completed a validated 53-item self-efficacy scale comprising five domains. Data were analyzed using ANOVA, repeated-measures ANOVA, and Kruskal–Wallis one-way analysis to evaluate differences in students' self-efficacy scores across academic years and between different programs. Results: Among …

Dental Students' Perceptions Of Patient Safety: A Cross-Sectional Study Using The Traditional Chinese Version Of The Attitudes To Patient Safety Questionnaire, Chen-Yi Lee, Ju-Hui Wu, Yu-Chih Lin, Shu-Yuan Lin

Journal of Medical Education

Objectives: This study aimed to examine the psychometric properties of the traditional Chinese version of the Attitudes to Patient Safety Questionnaire (APSQ-T) in a Taiwanese population (Study 1) and investigate dental students' perceptions of patient safety, identify their educational needs, and correlate these aspects to improve the curriculum (Study 2). Methods: Study 1 conducted a cross-sectional study using convenience sampling at a medical university in Taiwan. A total of 223 participants from the fields of dentistry, oral hygiene, nursing, and medicine were recruited to complete an anonymous survey for the validation of the APSQ-T. In Study 2, data collected from …

Expanding The Horizon Of Pocus Education: Integrating Nutritional Ultrasound Into Interprofessional Critical Care Training, Shih-Ching Lo, Chien-Wei Liu, Hsing-Chun Lin

Journal of Medical Education

No abstract provided.

Reexamining The Abraham Accords: The Dynamics Of The Abraham Alliance Amid Geopolitical Uncertainly, Wahyu Dwi Pambagyo, Ali Maksum

Journal Of Middle East and Islamic Studies

Several studies have discussed the bilateral economic impact of the Abraham Accords, but few of them have thoroughly examined how this agreement has evolved into a collective security framework amid global geopolitical changes. This study attempts to fill the existing research gap by analyzing the transformation of the Abraham Accords into the Abraham Alliance using the Balance of Power theory framework developed by Stephan M. Walt. Using a qualitative approach and case study mode, this study examines secondary data from 2020 to 2025, using academic journals, government policy documents, and reliable news media as sources. This study concludes that the …

QawāʿId Al-Fiqh On Government Energy Subsidies: Controlling Inflation Amid Economic Recovery, Nuzulul Firdaus, Nur Fatwa

Journal Of Middle East and Islamic Studies

The war between Russia and Ukraine significantly affected world life, one of which was the increase in world oil energy prices. Indonesia, in this case, which still imports a lot of energy, is also affected. The government needs to implement policies to face these global challenges, one of which is to provide subsidies for energy so that state budget funds can assist people's purchasing power for energy because if not, this will lead to an increase in the prices of goods and services so that there will be inflation. Still, on the other hand, Indonesia is also carrying out a …

The Concise Guide To Pharmacology 2025/26: Catalytic Receptors, Stephen P. H. Alexander, Doriano Fabbro, Chloe J. Peach, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Annie Beuve, Peter Brouckaert, Clare Bryant, John C. Burnett, Richard W. Farndale, Andreas Friebe, John Garthwaite, Adrian J. Hobbs, Gavin E. Jarvis, Laura Kilpatrick, Doris Koesling, Michaela Kuhn, Birgit Leitinger, David Macewan, Tom P. Monie, Lincoln R. Potter, Michael Russwurm, Harald H. H. W. Schmidt, Johannes-Peter Stasch, Scott A. Waldman

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear, accessible, and well-structured, rather than the scope of the content, which spans approximately 500 pages. The Concise Guide summarises the key pharmacological properties of around 1900 human drug targets, and nearly 7000 interactions, involving around 4400 ligands. While the content is a substantially condensed version of …

Geochemical Fingerprinting Of Tanzanian Uranium Deposits: The Insights Of Ree Ratios (La/Ce, Nd/Ce, And Sm/Nd) As A Provenance Tool, Lazaro H. Meza, John W. Kondoro, Iyabo T. Usman, Najat K. Mohammed, Titus A. Msagati, Mwingereza John Kumwenda, Mohamed S. Mazunga

Tanzania Journal of Science

Accurate uranium provenance determination is crucial for nuclear non-proliferation and environmental protection, yet a forensic-level geochemical framework for Tanzanian uranium deposits has been lacking. This study establishes a robust analytical method using forty-five samples from three major deposits (Mkuju, Manyoni, and Bahi), analyzing elemental compositions, particularly Rare Earth Elements (REEs), via ICP-MS, and validating results using Principal Component Analysis (PCA) and Hierarchical Cluster Analysis (HCA). Despite their proximity, the deposits exhibit distinct geochemical signatures as revealed by key REE ratios and anomalies. Mkuju (mean La/Ce 1.17, Nd/Ce 0.62, Sm/Nd 0.56) is characterized by a positive Europium (Eu) anomaly and heavy …

Detection Of Ultra-Trace Levels Of Copper In Seawater Using A Bare Gold Microwire Electrode And A Portable Digital Voltammeter, Luke M. Brosnan, Wade Lonsdale, Paul Pringle, Paul Lewtas, Samantha Ridgway, Sebastien Allard, Magdalena Wajrak

Research outputs 2022 to 2026

The accumulation of biomass on ship hulls (biofouling) can greatly decrease their fuel efficiency. Many antifouling coatings contain copper as a biocidal agent, which can be released during hull cleanings and is of particular concern when cleaning the hulls in situ (i.e., without dry docking). Previously established voltammetric methods for the detection of copper in seawater using a gold microwire electrode have been modified and adapted to a portable on-site voltammetric technique. Notable differences from previous voltammetric methods include the use of linear sweep voltammetry, analysis under atmospheric conditions, alternating the potential during the deposition period and the use of …