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The Feminine Way Of Campaigning: How Female Politicians Navigate Gender Bias, Jordan V. Pruitt Dec 2025

The Feminine Way Of Campaigning: How Female Politicians Navigate Gender Bias, Jordan V. Pruitt

2025 Fall Honors Capstones Projects - Archive

Women are rapidly taking over the world of politics, holding more elected positions than ever before. With the increase of women in politics, we begin to question how gender stereotypes and bias affect female politicians. There are numerous studies examining the public's perception of female candidates and how they are framed differently from their male opponents in the media; however, the main objective of this project is to learn how gender affects women’s campaign strategies or public personas, and how this differs from their male counterparts. Through interviews with women in locally elected positions, this study examines these issues through …


Innovative Philanthropy And Community-Based Approaches: Bridging Access To Sustainable Solutions In Low-Infrastructure Settings, Stephanie Zabriskie Dec 2025

Innovative Philanthropy And Community-Based Approaches: Bridging Access To Sustainable Solutions In Low-Infrastructure Settings, Stephanie Zabriskie

Journal of Nonprofit Innovation

Nonprofits operating in remote or low-infrastructure environments often encounter structural barriers that undermine social impact, especially for women and girls. These barriers are frequently attributed to funding shortages or lack of innovation. However, evidence from practice suggests that many social problems in these contexts persist not because solutions do not exist, but because they do not reach the communities who need them. This thought paper examines the role of nonprofit organizations as bridging agents that connect existing solutions to underserved communities, using women’s health access in East Africa as a case example. The analysis highlights the limitations of episodic philanthropic …


The Impact Of Work-Based Learning Experiences On Post-Secondary Readiness, Barbara A. Kain Dec 2025

The Impact Of Work-Based Learning Experiences On Post-Secondary Readiness, Barbara A. Kain

Student Scholarship

The primary goal of secondary education is preparing students for post-secondary success in an evolving global economy. Work-Based Learning (WBL) serves as a critical bridge between academic instruction and real-world application, yet participation rates remain low, particularly for marginalized student populations. This educational leadership project examines the impact of WBL on post-secondary readiness, addressing the disparity between federal policy mandates, such as the Carl D. Perkins Act, and actual student access.

Through a review of current literature, the project highlights the benefits of WBL regarding student persistence and economic mobility, while identifying structural barriers such as transportation and limited community …


Rethinking Wash: Innovative Pathways To Address Water, Health, And Poverty, Erica L. Jensen, Emma Indart, Faith Manchester, Sebastian Dorantes, Isabelle Stoddard Dec 2025

Rethinking Wash: Innovative Pathways To Address Water, Health, And Poverty, Erica L. Jensen, Emma Indart, Faith Manchester, Sebastian Dorantes, Isabelle Stoddard

Journal of Nonprofit Innovation

No abstract provided.


Academic Summaries: Global Access To Water And Sanitation, Erica Jensen Dec 2025

Academic Summaries: Global Access To Water And Sanitation, Erica Jensen

Journal of Nonprofit Innovation

No abstract provided.


Impact Of Flipped Classroom And Virtual Reality On Dental Students' Local Anesthesia Training, Yu-Wei Chiu, Ming-Yi Lu, Chih-Yu Peng, Yi-Tzu Chen Dec 2025

Impact Of Flipped Classroom And Virtual Reality On Dental Students' Local Anesthesia Training, Yu-Wei Chiu, Ming-Yi Lu, Chih-Yu Peng, Yi-Tzu Chen

Journal of Medical Education

Background and Objective: The goal of this study was to evaluate the impact of flipped classroom teaching and virtual reality (VR) on fourth-year dental students' comprehension of procedures and concepts in local anesthesia courses. Methods: The School of Dentistry at Chung Shan Medical University created a VR simulation that guided students through an inferior alveolar nerve block anesthesia procedure using HTC Vive headsets. Following traditional classroom lectures, students of the academic year 2022 participated in VR simulations and one-on-one practice, which was supplemented by instructional videos. Performance was assessed using a checklist, and feedback was collected via questionnaires. Results: Eighty-two …


Effect Of Nettle (Urtica Dioica L.) Seed Powder Supplementation On Some Important Quality Characteristics Of Cakes, Esra İrem Can, Kadi̇r Çebi̇ Dec 2025

Effect Of Nettle (Urtica Dioica L.) Seed Powder Supplementation On Some Important Quality Characteristics Of Cakes, Esra İrem Can, Kadi̇r Çebi̇

Turkish Journal of Agriculture and Forestry

The nutritional adjustment of food products has gained popularity in recent years as consumer interest in healthy eating has increased. Cake is a widely consumed cereal-based product containing such key nutrients as carbohydrate, fat, protein, fiber, vitamins, and minerals. In the present study, crust and crumb color, specific volume, microstructure, antimicrobial activity, total phenolic content, antioxidant activity, and sensory analyses were evaluated in four cake groups: a control cake (IT0) and cakes supplemented with 1% (IT1), 3% (IT2), and 5% (IT3) nettle seed powder. The addition of nettle seed powder to the cakes significantly reduced the crust (L*, a* and …


Mango Leaf Disease Detection And Classification Using A Federated Learning Based Lightweight Vision Transformer Model, Vinay Gautam, Prabhjot Kaur, Anand Muni̇ Mishra, Achyut Shankar, Laxman Singh Dec 2025

Mango Leaf Disease Detection And Classification Using A Federated Learning Based Lightweight Vision Transformer Model, Vinay Gautam, Prabhjot Kaur, Anand Muni̇ Mishra, Achyut Shankar, Laxman Singh

Turkish Journal of Agriculture and Forestry

The detection and management of horticultural crop diseases is crucial for enhancing productivity, reducing costs, and promoting environmentally sustainable practices. Recently, various techniques have been developed for managing crop-related issues, including leaf diseases and pest control. A centralized control approach has been implemented for disease detection. This centralized system faced significant challenges, including concerns over data privacy and the costs associated with data migration. This study addressed the problems with centralized solutions through a federated learning approach enhanced by the attention mechanism of the vision transformer (ViT). We investigated the key features of the federated learning method and propose a …


Jujubenet: A Dual-Stage Spectral Reconstruction Network For Rapid Jujube Moisture Content Estimation, Yalei Xu, Yang Li, Jing Nie, Jingbin Li Dec 2025

Jujubenet: A Dual-Stage Spectral Reconstruction Network For Rapid Jujube Moisture Content Estimation, Yalei Xu, Yang Li, Jing Nie, Jingbin Li

Turkish Journal of Agriculture and Forestry

Spectral analysis methods can nondestructively assess the quality of agricultural products but are limited by imaging speed and equipment costs. Therefore, they have not yet been fully integrated into engineering practices. This paper presents JujubeNet, a two-stage hyperspectral reconstruction model for detecting moisture content in jujubes. The first stage utilizes a generative pretrained Pix2Pix generative adversarial network (GAN) to generate RGB images of jujubes that mimic real camera styles and are pixel-to-pixel aligned with hyperspectral images. The second stage uses a transformer-based spectral reconstruction model to achieve hyperspectral reconstruction. Additionally, we developed a moisture content detection model based on hyperspectral …


State Of California Cannabis Reporting, University Of Mississippi – National Center For Cannabis Research And Education Dec 2025

State Of California Cannabis Reporting, University Of Mississippi – National Center For Cannabis Research And Education

California

No abstract provided.


Nurses' Implicit Bias Toward Older Adults: A Mid-Range Nursing Theory, Jennifer T. May Phd, Rn, Anp-Bc, Hanne Dolan, Jessica G. Rainbow Dec 2025

Nurses' Implicit Bias Toward Older Adults: A Mid-Range Nursing Theory, Jennifer T. May Phd, Rn, Anp-Bc, Hanne Dolan, Jessica G. Rainbow

Publications

This article describes the development of the Nurses' Implicit Bias Toward Older Adults Mid-Range Nursing Theory, which explains how biased care arises and affects older adults. Drawing from Pepper's contextual-development worldview, Parse's Humanbecoming Paradigm, and an emancipatory perspective, the theory integrates implicit social cognition to explain how nurses' backgrounds and unconscious processes influence clinical practice. Key "mitigation points" are identified for targeted interventions to address bias. This framework provides a foundation for future research on implicit bias in nursing, with implications for equitable health care delivery and improved older adult patient outcomes, supporting the advancement of nursing science and professional …


Second Look Commission 2025 Annual Report, Tennessee. Commission On Children And Youth. Dec 2025

Second Look Commission 2025 Annual Report, Tennessee. Commission On Children And Youth.

Second Look Commission Annual Report

No abstract provided.


Eucommia Ulmoides Extract Attenuates Oxidative Stress And Promotes Melanogenesis Via Wnt/Β-Catenin Signaling In B16 Cells And Mice, Xiaojin Liu, Yaqian Qiu, Xiaobing Lv, Lei Chang, Tiancheng Ji, Yefan Gu, Shuyue Chen Dec 2025

Eucommia Ulmoides Extract Attenuates Oxidative Stress And Promotes Melanogenesis Via Wnt/Β-Catenin Signaling In B16 Cells And Mice, Xiaojin Liu, Yaqian Qiu, Xiaobing Lv, Lei Chang, Tiancheng Ji, Yefan Gu, Shuyue Chen

Turkish Journal of Biology

Background/aim: Oxidative stress is a major contributor to melanocyte dysfunction and hair graying by impairing key signaling pathways. Eucommia ulmoides bark extract (EUE), rich in antioxidant phytochemicals, has shown potential in combating oxidative damage. This study investigated the protective and promelanogenic effects of EUE under hydrogen peroxide (H₂O₂)-induced oxidative stress, with a focus on the Wnt/β-catenin signaling pathway. Materials and methods: An oxidative stress model was established using B16 cells and a C57BL/6 mouse hair follicle model. Results: EUE significantly improved melanocyte survival and reduced intracellular reactive oxygen species (ROS). Mechanistically, EUE activated the Wnt/β-catenin pathway, leading to upregulation of …


Effects Of Different Perfluoroalkyl Substances On Rice Morphology, Physiology, And Biochemistry, Maryam M. Alomran, Muhammad Aqeel, Noreen Khalid, Noreen Akhter, Muhammad Kashif Irshad, Suliman Mohammed Suliman Alghanem, Fahad Mohammed Alzuaibr, Saher Nawaz, Omar Mahmoud Alzoubi, Muhammad Usman Akbar, Ali Noman Dec 2025

Effects Of Different Perfluoroalkyl Substances On Rice Morphology, Physiology, And Biochemistry, Maryam M. Alomran, Muhammad Aqeel, Noreen Khalid, Noreen Akhter, Muhammad Kashif Irshad, Suliman Mohammed Suliman Alghanem, Fahad Mohammed Alzuaibr, Saher Nawaz, Omar Mahmoud Alzoubi, Muhammad Usman Akbar, Ali Noman

Turkish Journal of Agriculture and Forestry

Perfluoroalkyl substances (PFASs) are synthetic organic compounds that have not been extensively studied in natural environments. The current study aimed to explore how PFASs, including perfluorooctane sulfonic acid (PFOS), perfluorobutane sulfonate (PFBS), perfluorohexanoate (PFHxA), perfluorotetradecanoate (PFTeDA), and perfluorobutanoate (PFBA), affect rice plants and influence their metabolism. These substances had a notable impact on root and shoot growth, reducing fresh and dry weights across various treatments compared to the control. These attributes were the least affected by PFOS treatment. PFBA treatment had significant adverse effects on chlorophyll a, b, and total chlorophyll levels, followed by the effects of PFHxA and PFTeDA. …


Exploring Bioactive Components Of Sugar Bean With Some Data Mining Algorithms: Relationships Between Antioxidants, Enzyme Inhibitors, And Minerals, İrem Ayran Çolak Dec 2025

Exploring Bioactive Components Of Sugar Bean With Some Data Mining Algorithms: Relationships Between Antioxidants, Enzyme Inhibitors, And Minerals, İrem Ayran Çolak

Turkish Journal of Agriculture and Forestry

Sugar bean (Phaseolus vulgaris L.) is a legume of notable nutritional and functional value, and its genotypes have substantial variation in bioactive compounds, antioxidant activity, mineral composition, and enzyme inhibition properties. This study aimed to comprehensively evaluate the biochemical and functional diversity of 10 sugar bean genotypes using data mining algorithms to identify superior candidates for functional food and nutraceutical development. Associations between the phytochemical profiles of sugar bean genotypes and their bioactivity, antioxidant capacity, and enzyme inhibition were modeled with classification and regression trees (CART), random forests (RF), and multivariate adaptive regression splines (MARS), while one-way ANOVA quantified varietal …


Arts & Literature: Cursed, Nadeem Zaman Dec 2025

Arts & Literature: Cursed, Nadeem Zaman

Genocide Studies and Prevention: An International Journal

No abstract provided.


หลักความคาดหวังอันชอบธรรมในกฎหมายปกครอง: พัฒนาการ แนวคิดเชิงเปรียบเทียบ และบทวิเคราะห์สำหรับประเทศไทย (The Principle Of Legitimate Expectations In Administrative Law: Development, Comparative Concepts, And Analysis For Thailand), Paphanphon Paphangkornphurin Dec 2025

หลักความคาดหวังอันชอบธรรมในกฎหมายปกครอง: พัฒนาการ แนวคิดเชิงเปรียบเทียบ และบทวิเคราะห์สำหรับประเทศไทย (The Principle Of Legitimate Expectations In Administrative Law: Development, Comparative Concepts, And Analysis For Thailand), Paphanphon Paphangkornphurin

Chulalongkorn University Law Journal

หลักความคาดหวังอันชอบธรรมเป็นกลไกสำคัญในระบบกฎหมายปกครองสมัยใหม่ที่มุ่งคุ้มครองความไว้วางใจของประชาชนต่อการกระทำของรัฐ บทความนี้ศึกษาพัฒนาการและสาระสำคัญของหลักการดังกล่าวในระบบกฎหมายเปรียบเทียบ ได้แก่ ระบบกฎหมายเยอรมนีที่หลักความคาดหวังอันชอบธรรมได้รับการยอมรับเป็น “หลักรัฐธรรมนูญทั่วไป” ภายใต้หลักนิติรัฐ และเชื่อมโยงกับหลักความมั่นคงแน่นอนทางกฎหมายและหลักความได้สัดส่วน ในอังกฤษหลักนี้มีจุดเริ่มต้นจากแนวคิดเรื่องความเป็นธรรมในกระบวนการก่อนขยายไปสู่การคุ้มครองผลประโยชน์เชิงเนื้อหาโดยใช้หลักการถ่วงดุลกับประโยชน์สาธารณะ ส่วนประเทศอื่น เช่น ออสเตรเลีย แคนาดา โปแลนด์ อินเดีย และฝรั่งเศส ต่างมีลักษณะการปรับใช้เฉพาะที่สะท้อนเป้าหมายร่วมกันในการจำกัดอำนาจรัฐและคุ้มครองความไว้วางใจของประชาชน สำหรับประเทศไทย ศาลปกครองไทยได้วางหลักการตีความสำคัญหลายประการทั้งการคุ้มครองเชิงเนื้อหาที่รับรองฐานะทางกฎหมายแม้คำสั่งจะถูกเพิกถอนในภายหลัง การชั่งน้ำหนักระหว่างความคาดหวังส่วนบุคคลกับประโยชน์สาธารณะ การเชื่อมโยงหลักความคาดหวังอันชอบธรรมกับหลักนิติรัฐ ข้อยกเว้นกรณีประมาทเลินเล่อร้ายแรงและการปกปิดข้อเท็จจริงที่มีสาระสำคัญ อย่างไรก็ตาม การปรับใช้ยังขาดความสม่ำเสมอในสาระสำคัญของการคุ้มครองความไว้วางใจของประชาชน บทความจึงนำเสนอแนวทางการพัฒนากฎหมายปกครองไทย ทั้งการปรับปรุงกฎหมายที่มีอยู่ให้ครอบคลุมรูปแบบความคาดหวังที่หลากหลาย การพัฒนาแนวทางการตีความของศาลที่ยอมรับการคุ้มครองทั้งในเชิงกระบวนการและเชิงเนื้อหา และการสร้างกลไกทางกฎหมายใหม่ เช่น คณะกรรมการไกล่เกลี่ยข้อพิพาท อันจะนำไปสู่การพัฒนาระบบกฎหมายปกครองไทยที่เป็นธรรม โปร่งใส และสอดคล้องกับหลักนิติรัฐอย่างแท้จริง


Effects Of Auricular Point Acupressure On Inflammatory Signaling In Chronic Low Back Pain: A Secondary Analysis Of A Randomized Controlled Trial, Nada Lukkahatai, Hongyu Wang, Xinran Huang, Wanqi Chen, Hulin Wu, Jennifer Kawi, Zhiyin Yu, Constance M Johnson, Paul Christo Dec 2025

Effects Of Auricular Point Acupressure On Inflammatory Signaling In Chronic Low Back Pain: A Secondary Analysis Of A Randomized Controlled Trial, Nada Lukkahatai, Hongyu Wang, Xinran Huang, Wanqi Chen, Hulin Wu, Jennifer Kawi, Zhiyin Yu, Constance M Johnson, Paul Christo

Faculty, Staff and Student Publications

Objective: Auricular point acupressure (APA) has shown promise for pain relief, but its biological mechanisms remain unclear. This study examined the effects of APA on inflammatory cytokines and explored the relationships between changes in inflammatory markers and clinical outcomes in older adults with chronic low back pain (cLBP).

Method: This secondary analysis utilized plasma samples from a three-arm randomized controlled trial (RCT) (NCT03589703) with 272 participants aged 65 years and older with cLBP. The participants were randomly assigned (1:1:1) to the targeted APA (T-APA), nontargeted APA (NT-APA), or education control (CG) groups for four weeks. Cytokine levels were …


Hasan Al-Banna And Islamic Education Politics: Weaving The Mind, Heart, And Spirit Of Struggle From Egypt To The World, Syamsul Kurniawan, Maimunah . Dec 2025

Hasan Al-Banna And Islamic Education Politics: Weaving The Mind, Heart, And Spirit Of Struggle From Egypt To The World, Syamsul Kurniawan, Maimunah .

Journal Of Middle East and Islamic Studies

This article examines Hasan al-Banna's thoughts on Islamic education politics, with a focus on the integration of three main dimensions: heart, mind, and the spirit of struggle, which form the foundation of the educational system he proposed from Egypt for the world. Through the Ikhwanul Muslimin movement, which originated in Egypt, al-Banna introduced an education that unified spirituality, intellectualism, and political struggle into a cohesive whole. This study employs the Atomic Habits theory by James Clear (2019), which emphasizes small, consistent changes that lead to significant impacts, to understand how al-Banna’s ideas on Islamic education can be viewed as a …


Microglial Expression Of Serotonin Receptors Reveals Parallel Regulation Of 5-Ht2b And Bdnf In The Rat Hippocampus, Andrei Turkin, Maria Sidorova, Ekaterina Kurilova, Natalia Alenina, Oksana Tuchina, Friederike Klempin Dec 2025

Microglial Expression Of Serotonin Receptors Reveals Parallel Regulation Of 5-Ht2b And Bdnf In The Rat Hippocampus, Andrei Turkin, Maria Sidorova, Ekaterina Kurilova, Natalia Alenina, Oksana Tuchina, Friederike Klempin

School of Graduate Studies Faculty Publications

Growing evidence suggests that psychiatric disorders are characterized by a prolonged inflammatory state, which may influence the efficacy of compounds targeting serotonin. Serotonin is a key signaling molecule in neuroplasticity of the adult hippocampus and involved in antidepressant action. Recent in vitro studies indicate the neurotransmitter may also facilitate the response to inflammation and potentially modulate microglial function towards neuroprotection. Using Tph2−/− rats depleted of brain serotonin, we examined microglial expression of various serotonin receptors (5-HTRs) in vivo in both the hippocampus and prefrontal cortex and assessed mRNA levels of cytokines and brain-derived neurotrophic factor (BDNF). We observed age-dependent and …


Utilization Of Phytogenic Silver Nanoparticles And Bacterial Agents For The Management Of Citrus Canker Disease, Zainab Jamil, Tariq Mukhtar, Muhammad Usman Raja, Muhammad Shahbaz, Jaya Seelan S. Seelan, Muhammed Tatar, Amjad Ali, Noor Fatima, Rahma Bejaoui, Ayşe Usanmaz Bozhüyük Dec 2025

Utilization Of Phytogenic Silver Nanoparticles And Bacterial Agents For The Management Of Citrus Canker Disease, Zainab Jamil, Tariq Mukhtar, Muhammad Usman Raja, Muhammad Shahbaz, Jaya Seelan S. Seelan, Muhammed Tatar, Amjad Ali, Noor Fatima, Rahma Bejaoui, Ayşe Usanmaz Bozhüyük

Turkish Journal of Agriculture and Forestry

Citrus is one of the most important and widely cultivated fruit crops globally. However, its productivity is increasingly threatened by various diseases, with bacterial infections being particularly the most destructive. Among these, citrus canker, caused by Xanthomonas axonopodis pv. citri (Xac), poses a significant challenge, requiring effective management strategies. Traditional approaches have shown limited success, but nanotechnology has emerged as a promising alternative for disease control. In this study, Xanthomonas spp. was isolated from two locations: Koont Farm and the National Agricultural Research Centre (NARC) citrus orchards in Islamabad, Pakistan. The isolates were identified through morpho-biochemical methods. Moreover, three Bacillus …


Optimizing Cultivated Land Productivity Through Integrated Fertilization Strategies And Uav-Assisted Management, Kejun Wang Dec 2025

Optimizing Cultivated Land Productivity Through Integrated Fertilization Strategies And Uav-Assisted Management, Kejun Wang

Turkish Journal of Agriculture and Forestry

This study investigates the impact of long-term fertilization modes on crop health and productivity using unmanned aerial vehicle (UAV)-assisted monitoring and a Q-learning-based approach for optimized fertilization strategies. An approximate state-matching Q-learning algorithm was developed to improve the efficiency of agricultural UAVs in fertilization tasks. The spatiotemporal patterns of cultivated land productivity under different fertilization regimes were analyzed in a long-term experiment. An evaluation system for cultivated land health productivity was established. The results indicated that the Q-learning algorithm enabled UAVs to achieve efficient task completion. QLASM outperformed traditional methods on all metrics. QLASM achieved a 92% task completion rate …


Short- Term Effects Of Cypermethrin Pesticide On Nutrient Levels And Microbial Communities In Tropical Soil Of Uganda, Mama N. Simon Dec 2025

Short- Term Effects Of Cypermethrin Pesticide On Nutrient Levels And Microbial Communities In Tropical Soil Of Uganda, Mama N. Simon

Tanzania Journal of Science

Cypermethrin is an insecticide widely used by farmers in Uganda to control pests and diseases. The widespread use leads to biomagnification, affecting humans and the ecosystem. This study examined the short-term effects of cypermethrin on soil macronutrients (N, P, K), meso-nutrients (Ca, Mg), and microbial communities (bacteria, fungi, and actinomycetes) in tropical Ugandan soils. Soil samples treated with cypermethrin and control were collected and analysed using standard methods of flame photometry for potassium (K), atomic absorption spectroscopy for calcium and magnesium, Wet-acid oxidation for nitrogen and phosphorus, and standard plate count techniques for microbial populations. The study used a Randomized …


The State Of The Child In Tennessee 2025, Tennessee. Commission On Children And Youth. Dec 2025

The State Of The Child In Tennessee 2025, Tennessee. Commission On Children And Youth.

The State of the Child in Tennessee

No abstract provided.


Limited Therapeutic Efficacy Of N-Acetyl-L-Leucine In A Mouse Model Of Cln1 Disease, Ewa A Ziółkowska, Nicole A Pagán Torres, Hsintsung Chen, Letitia L Williams, Elizabeth M Eultgen, Agnieszka Nowacka, Joshua T Dearborn, Hemanth R Nelvagal, Ineka T Whiteman, Frances M Platt, Jonathan D Cooper Dec 2025

Limited Therapeutic Efficacy Of N-Acetyl-L-Leucine In A Mouse Model Of Cln1 Disease, Ewa A Ziółkowska, Nicole A Pagán Torres, Hsintsung Chen, Letitia L Williams, Elizabeth M Eultgen, Agnieszka Nowacka, Joshua T Dearborn, Hemanth R Nelvagal, Ineka T Whiteman, Frances M Platt, Jonathan D Cooper

2020-Current year OA Pubs

UNLABELLED: CLN1 disease, one of the most severe forms of neuronal ceroid lipofuscinosis (NCLs or Batten disease), is a rapidly progressing pediatric neurodegenerative disorder caused by mutations in the

SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1038/s41598-025-32984-x.


Isg15 Dysregulates Endoplasmic Reticulum-Mitochondrial Contacts And Calcium Homeostasis In Ataxia Telangiectasia, Oygul Mirzalieva, Ryan E. Reed, Arthur L. Haas, Meredith A. Juncker, Patrick Logarbo, Jennifer M. Klein, David Worthylake, Shyamal D. Desai Dec 2025

Isg15 Dysregulates Endoplasmic Reticulum-Mitochondrial Contacts And Calcium Homeostasis In Ataxia Telangiectasia, Oygul Mirzalieva, Ryan E. Reed, Arthur L. Haas, Meredith A. Juncker, Patrick Logarbo, Jennifer M. Klein, David Worthylake, Shyamal D. Desai

School of Graduate Studies Faculty Publications

Dysregulation of endoplasmic reticulum and mitochondrial (ER:Mit) contacts and mitochondrial calcium (mitCa2+) homeostasis are found in several neurodegenerative disorders, including Ataxia Telangiectasia (A-T). However, the cellular basis of these defects remains unclear. Previously, we demonstrated that the aberrantly elevated Interferon-Stimulated Gene 15 (ISG15) pathway inhibits protein polyubiquitylation, its dependent protein turnover, and mitophagy pathways in A-T. Literature indicates that silencing of mitochondrial ubiquitin ligase 1 (MUL1) stabilizes mitofusin2 (MFN2) and attenuates mitCa2+ uptake from ER to Mit (mitCa2+influx) in primary neurons. We have replicated these findings in apparently healthy fibroblasts. We hypothesized that elevated ISG15 may inhibit ubiquitin-dependent MUL1-mediated degradation …


Subgroup Analyses Of The Phase 3 Focus Study Of Melphalan/Hepatic Delivery System In Patients With Unresectable Metastatic Uveal Melanoma, Jonathan S. Zager, Marlana Orloff, Pier Francesco Ferrucci, Junsung Choi, David J. Eschelman, Evan S. Glazer, Aslam Ejaz, Erika Richtig, Sebastian Ochsenreither, Sunil A. Reddy, Michael C. Lowe, Georgia M. Beasley, Anja Gesierich, Martin Gschnell, Reinhard Dummer, Ana Arance, Stephen William Fenwick, Joseph J. Sacco, Johnny John, Matthew Wheater, Christian H. Ottensmeier Dec 2025

Subgroup Analyses Of The Phase 3 Focus Study Of Melphalan/Hepatic Delivery System In Patients With Unresectable Metastatic Uveal Melanoma, Jonathan S. Zager, Marlana Orloff, Pier Francesco Ferrucci, Junsung Choi, David J. Eschelman, Evan S. Glazer, Aslam Ejaz, Erika Richtig, Sebastian Ochsenreither, Sunil A. Reddy, Michael C. Lowe, Georgia M. Beasley, Anja Gesierich, Martin Gschnell, Reinhard Dummer, Ana Arance, Stephen William Fenwick, Joseph J. Sacco, Johnny John, Matthew Wheater, Christian H. Ottensmeier

Department of Medical Oncology Faculty Papers

PURPOSE: To assess efficacy and safety in subgroups of patients treated with Melphalan/Hepatic Delivery System (melphalan/HDS), a drug/device combination for liver-directed treatment of metastatic UM (mUM) patients. Previously reported FOCUS study results indicated melphalan/HDS treatment provides a clinically meaningful response rate and favorable benefit-risk ratio in patients with unresectable mUM.

METHODS: Patients with mUM received treatment with melphalan (3.0 mg/kg ideal body weight) every 6-8 weeks for up to 6 cycles. Post hoc analyses of efficacy and safety were conducted for patient subgroups based on demographic and baseline disease characteristics.

RESULTS: 102 patients with mUM were enrolled; treatment was attempted …


Cross-Validated Probabilistic Bayesian Bert With Semantic Embedding Fusion For Robust Text Classification, Nabil M. Abdel-Aziz, Mahmoud Ibrahim, Khalid A. Eldrandaly Dec 2025

Cross-Validated Probabilistic Bayesian Bert With Semantic Embedding Fusion For Robust Text Classification, Nabil M. Abdel-Aziz, Mahmoud Ibrahim, Khalid A. Eldrandaly

Sustainable Machine Intelligence Journal

Sentiment Analysis is one of the most prominent branches of natural language processing. It deals with text classification to identify the public emotions and opinions which help businesses and political institutions make strategic decisions. This study proposes a sentiment classification model by integrating the Bayesian inference into the BERT transformer model, augmented with pre-trained GloVe embeddings. The primary objective is to refine sentiment analysis performance on IMDB movie reviews dataset by leveraging BERT's contextualized embeddings and the semantic richness of GloVe vectors, while incorporating Bayesian inference for uncertainty quantification. Using both 5-fold cross-validation and solo training, the model's performance was …


The Role Of Ai In Addressing The United Nations Sustainable Development Goals (Sdgs): A Comprehensive Survey, Walid Abdullah, Muhammad Nawaz, Basma Nasir, Muhammad Javed Ramzan Dec 2025

The Role Of Ai In Addressing The United Nations Sustainable Development Goals (Sdgs): A Comprehensive Survey, Walid Abdullah, Muhammad Nawaz, Basma Nasir, Muhammad Javed Ramzan

Sustainable Machine Intelligence Journal

Artificial Intelligence (AI) emerges as a transformative tool in addressing global challenges, particularly in achieving the United Nations Sustainable Development Goals (SDGs). This paper provides a comprehensive survey of how AI technologies contribute to addressing global challenges across social, economic, and environmental domains. By enabling advanced data analysis, predictive modeling, and automation, AI offers innovative solutions across sectors such as poverty reduction, healthcare, quality education, sustainable cities, climate action, and the protection of life on land and below water. Special attention is given to practical, real-world examples where AI enables more efficient resource management, predictive analytics, environmental monitoring, and data-driven …


Cover And Contents Dec 2025

Cover And Contents

Turkish Journal of Biology

No abstract provided.