Digital Commons Network^™

Per Se Driving Under The Influence Of Cannabis Statutes And Blood Delta-9-Tetrahydrocannabinol Concentrations Following Short-Term Cannabis Abstinence, Robert L. Fitzgerald, Anya Umlauf, Raymond T. Suhandynata, David J. Grelotti, Marilyn A. Huestis, Kyle F. Mastropietro, Igor Grant, Thomas D. Marcotte

Institute of Emerging Health Professions Faculty Papers

BACKGROUND: Several US states have per se laws using 2 or 5 ng/mL of delta-9-tetrahydrocannabinol (THC) as cutpoints for driving under the influence of cannabis, while some have zero-tolerance statutes. These cutpoints are considered prima facia evidence of driving impairment.

METHODS: In a cohort of people who regularly use cannabis (N = 190) we measured baseline concentrations of THC after instructing participants to abstain from cannabis for at least 48 hours. Baseline driving performance was evaluated using a driving simulator. We also measured blood THC concentrations serially following a smoking session (placebo or active cannabis).

RESULTS: Forty-three percent of the …

Quality Improvement Project: Educating Nursing Faculty On Medication Administration Labs To Improve Student Competency, Chelsea Pacheco

Doctor of Nursing Practice Projects

Medication administration errors are a leading cause of preventable harm in healthcare. Faculty play a critical role in ensuring nursing students develop the knowledge and confidence to give medications safely. A needs assessment at the project site revealed that only course coordinators were teaching medication administration and dosage calculation, leaving other faculty uncertain about how to teach these skills. This quality improvement project aimed to strengthen faculty confidence and create consistency in first-year instruction through a recorded educational video. Constructivist Learning Theory provided the foundation for active, experience-based learning. Lewin’s Change Theory guided the structured implementation process to support adoption …

Quality Improvement Project: Enhancing Diabetes Management Through Continuous Glucose Monitoring Device Education Among Providers Of Underserved Groups, Shaibu Rashid

Doctor of Nursing Practice Projects

This quality improvement project aimed to enhance diabetes management among underserved populations by increasing provider confidence and utilization of continuous glucose monitoring (CGM) devices in a Federally Qualified Health Center (FQHC). Despite CGM being recognized as a standard of care for patients requiring intensive insulin therapy, its adoption in FQHCs remains limited due to provider knowledge gaps, financial barriers, and workflow challenges. Based on Kurt Lewin’s change theory, the project employed a quasi-experimental one-group pretest–posttest design to evaluate the impact of an evidence-based educational intervention among six family practice providers. The intervention included interactive sessions on CGM device use, data …

Matthew Draper, Matthew Draper, Gus Guikema

Oral Histories of Farming along the Middle Rio Grande

No abstract provided.

Iso-Detr: A Novel Detection Transformer For Industrial Small Object Detection, Faisal Saeed, Anand Paul

School of Public Health Faculty Publications

Effectively detecting and assessing real-time structural and ecological parameters in contemporary manufacturing environments poses significant challenges, particularly in identifying minute objects within product images. The swift evolution of the industrial sector underscores the necessity for intelligent manufacturing environments to uphold stringent product quality standards. However, accelerating production processes at high speeds heightens the risk of defective product outcomes. This research addresses the challenges inherent in small object detection within industrial contexts, proposing an innovative detection transformer model tailored to modern manufacturing environments. The proposed model integrates a feature-enhanced multi-head self-attention block (FEMSA), merging cross-channel communication network and multiple multi-head self-attention …

Covering The Care: Utilization Rate Trends Among Adults Ages 19-64, Erica-Lyn Plante, Bethany Swanson

All Materials

This data brief presents a retrospective analysis of available medical claims data from NH Medicaid, NH Medicare and commercial insurance plans focusing on the trends of utilization rates for chosen medical interactions over a six-year period (2018-2023) among adults ages 19 to 64. This brief is the first of a three-part series of Covering the Care analytic reports exploring healthcare utilization trends in New Hampshire.

Optimizing The Bleaching Conditions For Mechanically Extracted And Solvent-Extracted Hempseed Oil, Preston C. Wilson, Md Sanaul Huda, Roque Evangelista, Clairmont L. Clementson, Sean Liu, Bingcan Chen, Ewumbua Monono

APC Fund Awardees

Hemp (Cannabis sativa) seed oil is recognized as a valuable oil due to its beneficial fatty acid profile, which includes a favorable balance of omega-6 and omega-3 fatty acids, making it highly desirable for edible and bioproduct applications. Crude hempseed oil contains high concentrations of chlorophyll, carotenoids, and other amphiphilic compounds that can negatively affect its appearance, stability, and downstream processing. Therefore, bleaching is a crucial step in removing these pigments after the degumming and neutralization processes. To optimize the bleaching process, a Box–Behnken response surface methodology was employed, focusing on three factors: time (15, 30, 45 min), temperature (100, …

Talking Sudep: Gaps, Confidence And Training Needs Among Spanish Epilepsy Professionals, Rohit Shankar

Peninsula Medical School

Objective: Sudden Unexpected Death in Epilepsy (SUDEP) is a major cause of epilepsy-related mortality, yetdiscussions about SUDEP in clinical settings remain inconsistent. This study aimed to assess the perspectives,practices, and barriers related to SUDEP counselling for epilepsy professionals in Spain.Methods: A cross-sectional online survey of 17 Likert style questions was disseminated via the Spanish EpilepsySociety between September 2023 and February 2024 to epilepsy professionals in Spain using a nondiscriminatory exponential snowballing technique leading to non-probability sampling. The survey was a validated instrument previously employed in similar international studies. Questions revolved around SUDEPcommunication and counselling. Descriptive and comparative analyses were conducted.Results: …

Second- Generation Korean American Adults’ Parenting Styles: The Role Of Acculturation And Enculturation, Teri Lynn Ku'ulei Kim

Walden Dissertations and Doctoral Studies

This quantitative survey study explored whether acculturation and enculturation predicted parenting styles among second-generation Korean American adults. The study was guided by Berry’s acculturation theory, Kim’s enculturation theory, and Baumrind’s parenting typology. Two research questions were addressed: (a) whether acculturation level predicted parenting style when controlling for parent age, gender, and number of children, and (b) whether enculturation level predicted parenting style when controlling for the same demographic variables. Emails and flyers were used to recruit participants from various Korean American groups on social media. A total of 146 Korean American parents completed anonymous online questionnaires about acculturation, enculturation, and …

Examining The Association Between User Fee Exemptions And Maternal Healthcare Utilization In Northern Ghana, Martina Hilton-Ansah

Walden Dissertations and Doctoral Studies

Abstract In Ghana, the user fee exemption policy, implemented in 2008, provides free maternal health services, which are a key component of the National Health Insurance Scheme (NHIS). Grounded in the Health Access Livelihood Framework, the purpose of this study was to determine the association between the user fee exemption policy and the utilization of antenatal care, facility-based delivery, and postnatal care in Northern Ghana, while controlling for sociodemographic factors. A quantitative approach was employed using secondary data from the Ghana Demographic and Health Surveys, encompassing women of reproductive age (15–49 years; N = 6,948). Logistic regression was used to …

Digital Health Literacy And Health Information-Seeking Behavior Among Black Mothers With Hypertensive Disorders During The Perinatal Period, Robyn Ford Kebede

Walden Dissertations and Doctoral Studies

Abstract The purpose of this qualitative phenomenological study was to explore how Black mothers navigated digital health platforms during the perinatal period while managing hypertensive disorders of pregnancy (HDPs). Guided by the social ecological model and the transactional model of eHealth literacy, the study examined how individual, interpersonal, and structural factors influenced digital health engagement and decision-making. Guiding questions focused on how mothers perceived the credibility and trustworthiness of online health information, how healthcare providers shaped and influenced digital health literacy and information-seeking behaviors, and how community and family support affected digital engagement. Data were collected through semi structured interviews …

Transforming Nurse Leaders: The Power Of Flexible Schedules In Healthcare, Emily Calabro, Rodica Pop

Biennial Convention (CONV)

Purpose: This pilot feasibility study investigated the impact of flexible work schedules on the mental, psychological, and physical health of healthcare workers within a large hospital system, aiming to identify innovative leadership strategies for workforce planning and development.

Background: Traditional work schedules often negatively impact productivity, well-being, and job satisfaction, contributing to challenges in recruiting and retaining nurses. This study explored the feasibility and benefits of flexible work schedules as a leadership initiative to improve workforce well-being and retention.

Methods: A quasi-experimental, mixed-methods, time-series design was implemented across a 12-hospital system with the partnership of 4-Day Global. Eligible leadership teams …

An Interdisciplinary Tabletop Simulation For Disaster Preparedness In Nursing Education, Lori Ann Minton, Gabri Warren, Lauren Rollins Lwanga

Biennial Convention (CONV)

The purpose of this study was to explore the effectiveness of an interdisciplinary tabletop simulation on student learning outcomes and American Association of Colleges of Nursing core competences related to disaster preparedness.

Nurses deliver a variety of services in the community and acute care settings and have historically been highly active in volunteerism. Disaster preparedness education can prepare future nurses to meet the needs of their communities during these emergency situations. There are opportunities to provide disaster preparedness education to nursing students using the AACN competencies and domains related to disaster response through simulation.

This IRB reviewed mixed methods study …

Building Research Capacity: Challenges And Lessons Of An Undergraduate Nursing Research Program, Elizabeth Ann Anderson, Leeanne B. Sherwin

Biennial Convention (CONV)

Background: The future of nursing scholarship relies on developing research capacity throughout the professional education trajectory. Nurse educators find motivating undergraduate nursing students to engage in the research process a challenge.¹ Understanding of the nursing research process and its link to optimal clinical practice is not well understood by undergraduate nursing students.² Global health challenges and issues impacting nursing education, such as faculty retirements and decreasing numbers of nurses pursuing research-focused doctoral degrees, necessitate introducing nursing students to the research process early, creatively, and consistently throughout their educational journey.³

Purpose: Describe the challenges and lessons …

Comparing The Impact Of Mentorship On Confidence Among Newly Graduated Registered Nurses, Margaret Matthews

Biennial Convention (CONV)

Newly licensed nurses require professional confidence to deliver quality patient care within today’s complex healthcare settings. While nursing programs provide a foundational knowledge base, many newly graduated nurses report challenges in clinical judgment and translating learned knowledge into practice, contributing to a lack of professional confidence. Extended mentorship during the transition to practice may offer a solution to address this gap.

This study aimed to measure the impact of mentorship on the confidence levels of newly graduated Registered Nurses (RNs) during their first six months of practice. A cohort of nine newly licensed RNs completed a standard twelve-week orientation program. …

Knowledge Of Menopause And Sources Of Information In Women And Men In The United States, Roxanne Ropponen

Biennial Convention (CONV)

Problem: When it comes to health management, knowledge is power. Unfortunately, menopause education is gravely lacking in the U.S., despite the fact that menopause symptoms have a significant effect on women’s lives, including their relationships with men. Most people obtain health information from online sources or family and friends, both of which can vary from highly accurate to extremely inaccurate. Nurses, the patient educators of the health care team, are in a position to provide evidence-based menopause education. In order to create and implement such education there must be an established understanding of the population's current knowledge and sources of …

Investigating The Mechanisms By Which Gut Microbiome Dysbiosis Contributes To The Autoimmune Response In Multiple Sclerosis, Abigail Houtrouw

Honors Theses

This literature review explores the multifaceted relationship between gut microbiome (GM) dysbiosis and multiple sclerosis (MS), highlighting key themes that advance understanding of disease pathogenesis and therapeutic potential for treatments targeting the gut. The review underscores the immune system dysregulation in MS, emphasizing the roles of T cells, B cells, and microglia in neuroinflammation and demyelination. Historically, MS pathogenesis was thought to be driven mainly by T-cell dysregulation, but current research highlights the additional roles of B-cells and microglia, the resident immune cells of the central nervous system (CNS). Additionally, this literature review identifies GM alterations and dysbiosis as critical …

Epigenome-Wide Association Study Of Nuclear Dna Methylation In Relation To Mitochondrial Heteroplasmy, Meng Lai, Kyeezu Kim, Yinan Zheng, Christina A Castellani, Scott M Ratliff, Mengyao Wang, Xue Liu, Jeffrey Haessler, Tianxiao Huan, Kwadwo Bonsu, Charles Newcomb, Kyler Mckessy, Lawrence F Bielak, Wei Zhao, Roby Joehanes, Jiantao Ma, Xiuqing Guo, Joann E Manson, Megan L Grove, Jan Bressler, Kent D Taylor, Tuuli Lappalainen, Silva Kasela, Thomas W Blackwell, Nicole J Lake, Jessica D Faul, Kendra R Ferrier, Stephen C Ekker, Lifang Hou, Charles Kooperberg, Alexander P Reiner, Kai Zhang, Patricia A Peyser, Myriam Fornage, Eric Boerwinkle, Laura M Raffield, April P Carson, Stephen S Rich, Yongmei Liu, Daniel Levy, Jerome I Rotter, Jennifer A Smith, Dan E Arking, Chunyu Liu

Faculty, Staff and Student Publications

We analyze 10,986 participants (mean age 77; 63% women; 54% non-White) across seven U.S. cohorts to study the relationship between mitochondrial DNA (mtDNA) heteroplasmy and nuclear DNA methylation. We identify 597 CpGs associated with heteroplasmy burden, generally showing lower methylation. These CpGs are enriched in dynamically regulated island shores and depleted in CpG islands, indicating involvement in context-specific rather than constitutive gene regulation. In HEK293T cells, we introduce a truncating mtDNA mutation (MT-COX3, mt.9979) and observe a positive correlation between variant allele fraction and methylation at cg04569152, supporting a direct mtDNA-nDNA epigenetic link. Many heteroplasmy-associated CpGs overlap with known methylation-trait …

Spartan Daily, December 2, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 165, Issue 40

Addressing The Ethnic Achievement Gap Through Culturally Relevant Teaching, Arienne Bowman

Masters Projects

Schools are meant to provide all students with equal opportunities to achieve academic success in the classroom yet as the student bodies of American schools becomes increasingly diverse, students of color are achieving academic success at lower rates than their peers. This in part may be due to the growing cultural disparity between teachers and students as the majority of teachers are white. By implementing culturally relevant teaching (CRT) teachers will be more prepared to address this cultural disparity and better equipped to create classroom spaces and lessons that better meet the needs of a diverse body of learners. CRT …

Multi-Omic Profiling Provides Insights Into The Heterogeneity, Microenvironmental Features, And Biomarker Landscape Of Small-Cell Lung Cancer, Mingchao Xie, Miljenka Vuko, Shashank Saran, Siyu Liu, Andrew G Chambers, Hana Baakza, Helen K Angell, Felicia Ng, Carl M Gay, Robert J Cardnell, Felix J Segerer, Alma Andoni, Jaime Rodriguez-Canales, Paul M Waring, Markus Schick, J Carl Barrett, Lauren A Byers, Giulia Fabbri

Faculty, Staff and Student Publications

Background: Greater understanding of differential therapeutic sensitivity, specifically to immunotherapy, in small-cell lung cancer (SCLC) is required.

Methods: We explored SCLC heterogeneity through integrated molecular characterization of tumor tissue samples from 159 treatment-naive patients, utilizing genetic, epigenetic, transcriptional, and proteomic profiling, immunohistochemistry staining for multiple biologically relevant markers including transcriptional subtype-defining proteins, and spatial immune profiling using multiplex immunofluorescence.

Results: Multi-omics analysis confirmed high heterogeneity across/within neuroendocrine and non-neuroendocrine subtypes. Methylomics analysis identified four methylome clusters that may enhance subtype prediction, prognosis, and longitudinal monitoring of subtype evolution. Immunohistochemistry analysis showed high MHC-I expression in non-neuroendocrine subtypes, which have greatest …

Inhibition Of Clostridioides Difficile-Specific Dna Adenine Methyltransferase Cama By Analogs Of S‑Adenosyl‑L‑Methionine, Jujun Zhou, Youchao Deng, Dan Yu, Taraneh Hajian, Masoud Vedadi, Xing Zhang, Robert M Blumenthal, Rong Huang, Xiaodong Cheng

Faculty, Staff and Student Publications

Epigenetically targeted therapies, especially those inhibiting S-adenosyl-l-methionine (SAM)-dependent methylations of DNA, mRNA, and histones, have advanced rapidly in cancer treatment. However, these therapies remain underexplored for antibiotic development, despite the growing threat of antimicrobial resistance. Here, we screened a focused library of SAM analogs against the DNA adenine methyltransferase CamA specific to the enteric pathogen Clostridioides difficile. At the same time, we examined six other adenine methyltransferases, including two bacterial DNA methyltransferases and four human RNA methyltransferases having distinct RNA substrates. Compound 113 selectively inhibited CamA (IC50 = 0.15 μM). In addition, compound 67 inhibited Caulobacter crescentus CcrM …

Characterizing Circulating Rare Cells In Peripheral Blood For Detecting And Monitoring Multiple Myeloma And Precursor States, Stephanie N Shishido, Jeremy Mason, Mohamed Kamal, Sonia Maryam Setayesh, Amishi U Vora, David Berrios, Luz Yurany Moreno Rueda, Krina Patel, Elisabet E Manasanch, Robert Z Orlowski, Peter Kuhn

Faculty, Staff and Student Publications

Multiple myeloma (MM) arises from abnormal plasma cells (PCs) progressing from precursor states, including monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). Understanding this transition and progression to overt MM requires improved non-invasive strategies. We employed a liquid biopsy approach to detect and characterize circulating PCs across disease states in 68 patients (MGUS = 11, SMM = 21, NDMM = 19, RRMM = 17) using multi-channel immunofluorescence staining and machine learning-assisted rare event detection. PCs were identified by CD138 and B-cell maturation antigen (BCMA) expressions, with distinct phenotypic subpopulations stratifying disease states. The D | CD138 | …

Factors Influencing Immediate Post-Angiographic Occlusion Outcomes In Intracranial Aneurysms Treated With The Woven Endobridge Device: A Multi-Center Analysis And Predictive Model From The Worldwideweb Consortium, Muhammed Amir Essibayi, Mohamed Sobhi Jabal, Hasan Jamil, Hamza Adel Salim, Basel Musmar, Nimer Adeeb, Mahmoud Dibas, Nicole M Cancelliere, Jose Danilo Bengzon Diestro, Oktay Algin, Sherief Ghozy, Sovann V Lay, Adrien Guenego, Leonardo Renieri, Joseph Carnevale, Guillaume Saliou, Panagiotis Mastorakos, Kareem El Naamani, Arbaz A Momin, Eimad Shotar, Markus Möhlenbruch, Michael Kral, Charlotte Chung, Mohamed M Salem, Ivan Lylyk, Paul M Foreman, Hamza Shaikh, Vedran Župančić, Muhammad U Hafeez, Joshua Catapano, Muhammad Waqas, Muhammed Said Besler, Yasin Celal Gunes, James D Rabinov, Julian Maingard, Clemens M Schirmer, Mariangela Piano, Anna L Kühn, Caterina Michelozzi, Robert M Starke, Ameer Hassan, Mark Ogilvie, Anh Nguyen, Jesse Jones, Waleed Brinjikji, Marie T Nawka, Marios Psychogios, Christian Ulfert, Bryan Pukenas, Jan-Karl Burkhardt, Thien Huynh, Juan Carlos Martinez-Gutierrez, Sunil A Sheth, Diana Slawski, Rabih Tawk, Benjamin Pulli, Boris Lubicz, Pietro Panni, Ajit S Puri, Guglielmo Pero, Eytan Raz, Christoph J Griessenauer, Hamed Asadi, Adnan Siddiqui, Elad I Levy, Deepak Khatri, Neil Haranhalli, Andrew F Ducruet, Felipe C Albuquerque, Robert W Regenhardt, Christopher J Stapleton, Peter Kan, Vladimir Kalousek, Pedro Lylyk, Srikanth Boddu, Jared Knopman, Stavropoula I Tjoumakaris, Hugo H Cuellar-Saenz, Pascal M Jabbour, Frédéric Clarençon, Nicola Limbucci, Vitor Mendes Pereira, Aman B Patel, David J Altschul, Adam A Dmytriw, Worldwideweb Consortium Collaborators

Faculty, Staff and Student Publications

The Woven EndoBridge (WEB) device treats wide-necked bifurcation aneurysms, but occlusion rates vary. This study aims to identify factors associated with immediate WEB device occlusion. Data from patients treated with WEB devices across 36 sites were analyzed. Machine learning algorithms and ordinal regression models were developed to predict immediate incomplete occlusion for ruptured and unruptured aneurysms. The study included 1565 patients, with 436 ruptured and 1129 unruptured aneurysms. Immediate complete occlusion was achieved in 38.3% of ruptured and 32.8% of unruptured aneurysms. For ruptured aneurysms, the CatBoost classifier achieved an AUROC of 0.69. Key predictors of incomplete occlusion included pretreatment …

Individualized Perioperative Blood Pressure Management In Patients Undergoing Major Abdominal Surgery: The Improve-Multi Randomized Clinical Trial, Bernd Saugel, Agnes S Meidert, Frank M Brunkhorst, Robert Bischoff, Joseph Esser, Minca Mattis, Pauline Naue, Katharina Vogel, Alina Bergholz, Moritz Flick, Alina Kröker, Dominik X Müller, Kristen K Thomsen, Christina Vokuhl, Mirja Wegge, Sebastian Bratke, Martin Graeßner, Bettina Jungwirth, Sebastian Schmid, Carla D Grundmann, Jan M Wischermann, Patrick Kellner, Moritz Steinhaus, Linda Grüßer, Sina M Coldewey, Kai Zacharowski, Patrick Meybohm, Marit Habicher, Alexander Zarbock, Amelie Zitzmann, Svenja Letz, Claudia Neumann, Jan Larmann, Thomas Renné, Linda Krause, Eik Vettorazzi, Antonia Zapf, Annemarie Carlstedt, Daniel I Sessler, Karim Kouz

Faculty, Staff and Student Publications

Importance: Intraoperative hypotension is associated with organ injury. However, it remains unknown if targeted blood pressure management during surgery can improve clinical outcomes.

Objective: To evaluate whether individualized vs routine perioperative blood pressure management during major abdominal surgery improves clinical outcomes in patients considered at high risk of postoperative complications.

Design, setting, and participants: This randomized single-blind clinical trial enrolled patients 45 years or older undergoing elective major abdominal surgery with general anesthesia expected to last 90 minutes or longer who had at least 1 additional high-risk criterion between February 26, 2023, and April 25, 2024, at 15 German university …

Patient And Procedural Factors Associated With Same-Day Discharge Following Pulsed Field Ablation For Atrial Fibrillation: Insights From The Disrupt-Af Registry., Amin Al-Ahmad, Jose Osorio, John Day, Jeremiah Wasserlauf, Devi Nair, Robert Eckart, Dwayne Campbell, Jonathan Dukes, Frank Cuoco, John Costello, Jason Zagrodzky, David Kessler, Gustavo Morales, Anil Rajendra, Saumil Oza, Amr Barakat, Anthony Magnano, Anish Amin, Joshua Silverstein, Amit Thosani, Susan M Bezenek, Paul Zei, Chang Dai, Andrea Natale, Rodney Horton

OhioHealth Research Institute Articles

BACKGROUND: Same-day discharge (SDD) after catheter ablation for atrial fibrillation (AF) may improve patient satisfaction and optimize healthcare resources. Pulsed field ablation (PFA) offers a favorable safety profile, potentially enabling broader adoption of SDD strategies.

OBJECTIVE: To evaluate site-level practice patterns and participant- and procedure-related factors associated with SDD after de novo PFA for AF.

METHODS: We analyzed data from participants in the DISRUPT-AF registry, a prospective, multicenter study evaluating ablation acute outcomes with a pentaspline PFA catheter. We examined participant and procedure characteristics associated with both SDD planning and success.

RESULTS: SDD was preplanned for 81% (1203) of all …

Hif-2-Dependent Regulation Of Pthrp And Paraneoplastic Hypercalcemia In Aggressive Clear-Cell Renal Cell Carcinoma, Arijit Mal, Bingqing Xie, Zane Gray, Charlotte Small, Susmita G Ramanand, Yunpeng Gao, Vanina Toffessi Tcheuyap, Sashi Debnath, Alana Christie, Jeffrey Miyata, Brooklyn Jackson, Hua Zhong, Boning Gao, Jay Lohrey, Naim M Maalouf, Sangeetha M Reddy, John D Minna, Ivan Pedrosa, Xiankai Sun, Ram S Mani, Payal Kapur, James Brugarolas

Faculty, Staff and Student Publications

Renal cell carcinoma (RCC) patients with hypercalcemia (HC) have worse outcomes. HC often involves PTHrP, and the role of HIF-2 is incompletely understood. Leveraging RCC tumorgraft (TG) models of HC, which were characterized by tumor cell autonomous inflamatory/immune signatures, we show that HIF-2 inhibition with PT2399 frequently normalized calcium, downregulated circulating PTHrP and reduced HIF-2 binding to the PTHLH (PTHrP) promoter. Likely contributing to the selective induction of PTHrP in a subset of HIF-2-dependent tumors, the PTHLH locus was generally more accessible in TG(HC). However, PTHLH chromatin accessibility was grossly unaffected by PT2399, unlike elsewhere (including EPO locus in a …

Examining The Relationship Between School Location, Neighborhood Resources And Advancement Courses Offerings, Eudarius Jones

Electronic Theses and Dissertations Archive

This study addresses a critical gap in educational equity research by examining how neighborhood-level factors intersect to shape access to rigorous academic programming, a key gateway to postsecondary success. Integrating geospatial visualization and hierarchical linear modeling within a critical geography framework, the study investigates how structural inequalities—rooted in race, poverty, and place—influence advanced course-taking opportunities across the Memphis metropolitan region. Data sources included the U.S. Department of Education’s Common Core of Data (CCD) for district-level enrollment and school type, the U.S. Census and American Community Survey (ACS) for demographic and socioeconomic indicators, and the National Center for Charitable Statistics (NCCS) …

The George-Anne

The George-Anne

No abstract provided.

Final Butte Mine Waste Repository Geotechnical Investigation Work Plan, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.