Digital Commons Network^™

The Right Kind Of Rarefaction: Coronary Microvascular Remodeling In Right Ventricle Failure, Cyrus Vahdatpour, Katharine Clapham, Steven M. Kawut, Kirk Jones, John J. Ryan, Danielle Petty, Shannon Talbot, Kimberly Dumoff, Ellen C. Keeley, Priti Lal, Andrew J. Bryant, Alex M. Parker, Jeremy A. Mazurek, Leonid Mirson, Andrew Murphy, Andrew Baird, Megan Schwietert, Alissa F. Schurr, Andrew Stein, Scott M. Hansen, Zhining Ou, Angela P. Presson, Dylan Miller

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Right ventricular failure (RVF) is the primary determinant of outcomes in pulmonary hypertension (PH). Coronary microvascular dysfunction (CMD), defined by capillary rarefaction and endothelial dysfunction, may contribute to RVF but remains poorly characterized. CMD, defined by capillary rarefaction and endothelial dysfunction, may contribute to RVF through impaired myocardial oxygen delivery and fibrotic remodeling.

OBJECTIVES: To characterize right ventricle (RV) CMD and myocardial fibrosis in explanted human hearts and examine associations with echocardiographic and hemodynamic indices of RVF across PH subtypes.

METHODS: We retrospectively analyzed 57 adult patients who underwent orthotopic heart transplantation at 3 institutions (2023-2024). Explanted hearts were …

Leveraging Student Data To Assess, Inform, And Develop Teachers Capacities, Nathan D. Koerber, Kenneth J. Fasching-Varner

Northwest Journal of Teacher Education

This quantitative study analyzed 47 survey responses to gauge in-service, pre-licensed teacher, and paraprofessional perceptions of cultural competency. Participants responded to the Central Vancouver Island Multicultural Society’s Cultural Competence Self-Assessment Checklist (Alpha = 0.7) to explore their awareness, knowledge, and skills in cultural competency. Moreover, through the application of Culturally Responsive Teaching (CRT) as a theoretical framework, this study highlighted how these perceptions related to culturally responsive teaching and provided several implications for their future preparation to further develop their cultural competency through the tenets of CRT. The analysis identified participant unfamiliarity with privilege and its impact, as well as …

In-Between Spaces: First-Generation College Immigrant Experiences, Silvina Alamo Sousa-Ransford

Dissertations and Theses

It is human nature to seek a sense of belonging, acceptance, and community. College students also share this desire for connection in higher education, but some face more barriers and challenges. This study examined the experiences of first-generation college students who are also immigrants. The goal was to understand how to best support students in college, including through academic advising, at a four-year research university in the Pacific Northwest. To gain insight into the students' experiences, I interviewed participants using narrative qualitative methods guided by the framework of sense of belonging and analyzed the data utilizing Bronfenbrenner's Ecological Model. The …

Bridging Modalities: Enhancing Multimodal Sentiment Analysis For Social Media Networks, Misbah Ul Hoque

LSU Doctoral Dissertations

Social media platforms like X (formerly Twitter) serve as rich sources of textual and visual information, making multimodal sentiment analysis essential for understanding complex human emotions. This dissertation aims to advance multimodal sentiment analysis by improving the semantic alignment and fusion of textual and visual features, thereby enabling more accurate and context-aware sentiment interpretation of social media content.

To address challenges in multimodal integration, this work proposes two complementary MSA approaches. The first approach introduces a similarity-based multi-layer attention neural network (SiMANN) that enhances modality integration through cosine-based similarity fusion and modality-specific attention to emphasize salient features in text and …

Cross Level Effects Of Digitalization And Environment Management On Energy Savings In Chinese Manufacturing Firms, Zijin Wang, Jaime Ortiz, Yuanheng Li, Lingyan Shi

International Business and Entrepreneurship Faculty Publications

The pathway to energy savings requires coordination of technological progress and policy implementation. Specific factors are needed to bridge cross-disciplinary conversations within just one system. Regional public digital infrastructure and enterprises’ environmental management capabilities are incorporated into a research framework on digitalization and energy savings based on the theory of digital ecosystems. A cross-level moderating model is constructed using data from 2014 to 2022 for 650 Chinese enterprises listed in the manufacturing industry to examine the impact of various digital technologies on energy savings, moderating effect of digital infrastructure and the constraint effect of environmental management systems (EMSs). Artificial intelligence …

Startrac-Cyp2d6: A Method For Cyp2d6 Allele-Specific Copy Number Determination Using Digital Pcr, Wendy Y. Wang, Erin C. Boone, Lancy Lin, David Joun, Andrea Gaedigk

Manuscripts, Articles, Book Chapters and Other Papers

Background: Accurate CYP2D6 genotyping is essential for pharmacogenetic-guided prescribing of many clinically used medications. While digital PCR is increasingly used to determine copy number (CN) status for accurate phenotype prediction, there are few convenient methods to discriminate duplicated alleles and diplotypes such as CYP2D6*2/*4x2 and *2x2/*4, which predict intermediate and normal metabolizer phenotypes, respectively. We developed a novel method, StarTRAC-CYP2D6, "Targeted Reporting of Allele-specific CNV", for determining the number of specific CYP2D6 star allele copies. Additionally, we explored the impact of DNA input and interfering variants on CN assay performance.

Methods: Coriell …

Line Transect Surveys And Initial Estimates Of Abundance For Sea Turtles In Biscayne National Park, Florida., Kathryn C. Price

All HCAS Student Capstones, Theses, and Dissertations

The loggerhead (Caretta caretta) and green (Chelonia mydas) turtle are two species of marine megafauna that have suffered abundance declines due to increased anthropogenic pressures. Assessing the distribution and abundance of sea turtles is essential for conserving and managing these imperiled species; however, assessing sea turtle populations poses difficulties due to the sea turtles’ highly migratory nature. Distance sampling surveys are extensively used to study populations of wide-ranging species. In this study, vessel-based line transect survey data collected throughout 2024 were used to estimate overall and seasonal sea turtle abundances and distribution throughout Biscayne National Park, …

Strategies Property Management Leaders Use To Strengthen Employee Engagement In The Workplace, Angela Hartleigh

Walden Dissertations and Doctoral Studies

Lack of employee engagement presents a significant risk and cost across the property management industry. Property management business leaders are concerned with this challenge because employee engagement directly affects performance efficiency and employee turnover costs. Grounded in the self-determination theory, the purpose of this qualitative pragmatic inquiry was to explore strategies property management leaders use to strengthen employee engagement in the workplace. The participants were six purposefully selected property management business leaders in the United States. Data were collected using semistructured interviews and a review of public industry documents. Through thematic analysis, six themes were identified: (a) communication, (b) mentorship, …

December 2025, Office Of Sustainability

Office of Sustainability Newsletter

No abstract provided.

Patient-Reported Experience Measures For Person-Centred Care: A Survey For The Development And Psychometric Testing Of A Targeted Measure, The Epcc-14, Ryan Statton, Lena Rosenlund, James Close, Anna Dencker, Helen Lloyd

School of Psychology

Objectives This study aims to develop a robust, targeted measure of patient experiences of person-centred care (PCC), informed by the lived experiences of patients with chronic illness using the psychometric theory of Rasch measurement. Design The Rasch measurement model was used to analyse the psychometric functioning of 57 candidate items and select appropriate items for a targeted measure. Setting Participants were recruited from Prolific.com, having experience of both chronic or long-term illness and first-hand experience of primary or secondary care in the UK healthcare setting and completed a survey containing PCC items and descriptors of healthcare experience. Participants Data from …

Global, Regional, And National Burden Of Cardiovascular Diseases And Risk Factors In 204 Countries And Territories, 1990-2023, Global Burden Of Cardiovascular Diseases And Risks 2023 Collaborators, Benjamin A. Stark, Nicole K. Decleene, Emily C. Desai, Johnathan M. Hsu, Catherine O. Johnson, Laura Lara-Castor, Kate E. Legrand, Prof Bhoomadevi A, Mohammad Amin Aalipour, Hasan Aalruz, Bedru J. Abafita, Ukachukwu O. Abaraogu, Mohammad Abavisani, Nasir Abbas, Madineh Abbasi, Mohammadreza Abbasian, Hedayat Abbastabar, Abdallah H.A. Abd Al Magied, Samar Abd Elhafeez, Prof Ahmed Abdelalim, Omar M. Abdelfattah, Prof Reda Abdel-Hameed, Mahmoud Abdelnabi, Prof Wael M Abdel-Rahman, Parsa Abdi, Wakgari Mosisa Abdisa, Daba Abdissa, Arman Abdous, Mujahid Abdullah

Peninsula Medical School

Background: Cardiovascular diseases (CVDs) are the leading cause of mortality and are among the foremost causes of disability globally. CVD burden has continued to increase in most countries since 1990, with trends driven by changing exposures to harmful risk factors, population growth, and population aging. Objectives: We report estimates of global, national, and subnational CVD burden, including 18 subdiseases and 12 associated modifiable risk factors. We analyzed change in CVD burden from 1990 to 2023 and identified drivers of change including population growth, population aging, and risk factor exposure. Methods: The Global Burden of Disease (GBD) 2023 study, a multinational …

Early Life And Post-Traumatic Growth Among Urban African Americans, J. Howard Streeter Iii

Walden Dissertations and Doctoral Studies

Post-traumatic growth (PTG) has received increasing attention in psychological research, yet the PTG experiences of African Americans remain underexplored. Trauma researchers have established the common prevalence of trauma within this population, but there have been very few studies on how African Americans traverse trauma according to PTG. Understanding PTG in this population is essential for clergy, coaches, parents, counselors, and others who work in these communities. The purpose of this quantitative survey study was to determine whether there was a statistically significant relationship between rumination, religious orientation, religious commitment, and stressful life events (SLEs) and PTG among urban African American …

An International Comparison Of Staff Perceptions Of Professional Governance, Roberta Kaplow, Polly Willis, Birgit Vogt, Fanny Grüssel-Griethe, Janina Schweiger

Biennial Convention (CONV)

Objectives: The objectives of this study were to evaluate differences among RNs and nurse leaders’ perceptions regarding professional governance (PG), and discern differences in perceptions regarding demographic variables, and determine if there are differences in perceptions of SG between two hospitals.

Background: Data suggest a relationship between PG and improved patient outcomes, nurses’ job satisfaction, and workplace engagement.

Methods: A cross-sectional descriptive comparative design was used. Perception of SG at two academic medical centers were compared. The United States (US) center has Magnet designation; the German center is pursuing designation. Participants completed a demographics questionnaire and the IPNG 3.0 (50 …

Engaging Students In Gap Analysis In Global Service-Learning In Low-Resource Settings, Mabel Ezeonwu, Amanda Sendele

Biennial Convention (CONV)

Purpose: To describe a case study-based approach for training students in gap analysis and cultural humility to articulate and support community health needs in low-resource settings.

Background: Through collaborative academic-community partnership¹, an intensive service-learning program on health promotion was implemented in low-resourced indigenous Mayan communities of Guatemala, as part of a quarter-long 2023 hybrid study abroad course. The goals of the program were to 1) support the primary healthcare needs of the communities 2) allow students to build competencies in global health (GH) practice, including a) articulate barriers to health and healthcare in low-resource settings and b) …

Breaking The Silence: Addressing The Crisis Of Osec & The Knowledge Gap Among Health Professionals, Toni Morris, Elizabeth Ziff

Biennial Convention (CONV)

OSEC is a significant public health crisis globally. It involves the sexual abuse of minors through the internet, including creating, sharing, or possessing sexual material featuring children. OSEC is widespread yet often hidden due to its sensitive nature, making it challenging to address openly. The increasing use of digital technology and social media exacerbates this problem, providing predators with more tools to exploit children.

Children are especially vulnerable, facing serious threats to their physical and emotional well-being. Despite global efforts to combat OSEC, the ubiquity of the internet and advancements in technology have made prevention and intervention difficult. Early identification …

A Double-Edged Sword: Ethical And Psychological Implications Of Apoe Genotype Disclosure Across The Lifespan, Diego Iacono

Department of Neurology Faculty Papers

The apolipoprotein E (APOE) gene is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD), with the ε4 allele increasing risk and decreasing the average age of onset. While APOE genotyping is primarily used in research or clinical settings for patients with memory concerns, interest in disclosing APOE status to asymptomatic individuals—particularly during early adulthood—is growing. This trend is fueled by the rise of direct-to-consumer genetic testing and emerging prevention-focused clinical trials. However, ethical debates remain unresolved about the potential harms of early disclosure, including anxiety, stigma, and misunderstanding of probabilistic risk. Conversely, some argue that knowledge of APOE …

Using Gnotobiotic Mice To Decipher Effects Of Gut Microbiome Repair In Undernourished Children On Tuft And Goblet Cell Function, Yi Wang, Hao-Wei Chang, Jiye Cheng, Daniel M Webber, Hannah M Lynn, Matthew C Hibberd, Clara Kao, Ishita Mostafa, Tahmeed Ahmed, Michael J Barratt, Jeffrey I Gordon

2020-Current year OA Pubs

Studies have implicated perturbations in the postnatal development of the gut microbiome as a contributing factor to childhood undernutrition. Compared to a standard ready-to-use supplementary food, a microbiome-directed complementary food (MDCF-2) designed to repair these perturbations produced superior improvements in ponderal and linear growth in clinical trials of Bangladeshi children with moderate acute malnutrition. Here, "reverse translation" experiments are performed where intact fecal microbiomes collected from trial participants before and at the end of treatment are introduced into female gnotobiotic mice just after delivery of their pups. Pups received diets designed to resemble those consumed by children in the trials …

Statistically Significant Association Does Not Imply Improvement In Prediction Of Clinical Outcomes, Shu Jiang, Bernard A Rosner, Graham A Colditz

2020-Current year OA Pubs

UNLABELLED: In the current landscape of clinical studies, the concept of statistically significant association is often mixed up with the expectation of improved prediction performance. We discuss the two concepts, association and prediction, and present the epidemiologic principles and statistical constructs that underlie the discrepancy between statistically significant associations and the rationale for their lack of impact on improving prediction in terms of discrimination. This issue is illustrated using an existing breast cancer dataset. The concept of statistically significant association should not be mixed up with the expectation of improved discrimination performance. Although some markers may not markedly improve discrimination, …

Fucosylated N-Glycan Landscape Of Triple-Negative Breast Cancer, Danielle A Scott, Souvik Seal, Laura Spruill, Jaclyn Dunne, Graham Colditz, Anand S Mehta, Richard R Drake, Marvella E Ford, Peggi M Angel

2020-Current year OA Pubs

UNLABELLED: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer lacking targeted therapies. Although aberrant N-glycosylation is a hallmark of malignancy, the specific roles of core-fucosylated (CF) and outer arm-fucosylated (OAF) N-glycans in TNBC progression and patient survival remain underexplored. This study utilized multiplexed glycomics by matrix-assisted laser desorption/ionization imaging mass spectrometry to spatially profile 348 N-glycans in 59 TNBC tumors with clinical characteristics including survival data. Spatial analysis revealed distinct localization patterns of CF and OAF isomers within tumor microenvironments. Strikingly, OAF glycans, but not CF, were strongly associated with tumor stage, with expression increasing from stage …

Readability Analysis Of Aaos And Assh Shoulder And Elbow Patient Education Online Content: A 9-Year Follow-Up Study, Connor Parry, Teresa Veselack, Matthew Doscher, Bryan G. Beutel

Student Publications

Given the progressive spread of medical misinformation, access to understandable educational content from trusted sources has become increasingly more crucial for patients. Online patient education materials, particularly from specialty organizations, have been criticized for being too complex for the average reader. It is advised that this information be at or below the 6^th-grade reading level. This study is a 9-year follow-up to an analysis conducted in 2013 which evaluated the overall readability of educational articles from the American Academy of Orthopaedic Surgeons (AAOS) and American Society for Surgery of the Hand (ASSH) websites related to shoulder and elbow …

Christmas Calories And Hallmark Movies, Mark Volkers

Faculty Work Comprehensive List

"Christmas is a great time to indulge in a few sweets, while also enjoying hearty meals that give us strength for the new year to come."

Posting about ­­­­­­­­balancing seasonal comforts with faithful living from In All Things, an online hub that offers insight into maintaining and faithful and orthodox Reformed Christian worldview while fearlessly engaging in every aspect of contemporary life – until all is made new.

Christmas Calories and Hallmark Movies

Proposed Medical School Curricula For 3d Printing, Danielle Heiser, David H Ballard, Et Al.

2020-Current year OA Pubs

BACKGROUND: 3D printing is increasingly utilized in medical education, providing a hands-on approach to anatomical learning, surgical planning, and interdisciplinary collaboration. Despite growing interest, standardized curricula incorporating 3D printing into medical education are lacking.

METHODS: A multidisciplinary team of medical educators, engineers, and students developed three distinct curricular models to integrate 3D printing into undergraduate medical education. These models include (1) integration into anatomy coursework, (2) a fourth-year clerkship elective, and (3) a pre-clerkship elective. The outline for each curriculum was designed to be adaptable across institutions, emphasizing hands-on learning, imaging segmentation, basic elements of computer-aided design (CAD), and 3D …

Netherton Syndrome: A Systematic Review Of The Challenges Of Diagnosis And Treatment, Maximus S. Reese, Ryan Nguyen, Noor Chughtai, Philip J. Haynos, Salma Alkhatib, Shantanu Amin, Ethan Speer, Jared Nichols

Student Publications

Netherton syndrome is an autosomal recessive genodermatosis caused by biallelic mutations in the SPINK5 gene, a gene that codes for lymphoepithelial Kazal-type-related inhibitor 1 (LEKT1) protein. This disorder is characterized by erythroderma, ichthyosis, hair shaft abnormalities, and immune dysregulation. While there is increasing research and recognition of Netherton syndrome, much remains unknown, with limited knowledge of the history, manifestations, and responses to therapies. The purpose of this study was to review case reports of Netherton’s to draw conclusions from patient demographics, symptoms, treatment, and outcomes. A systematic review of 30 case reports and clinical studies on Netherton syndrome was conducted, …

Optimizing Perioperative Antibiotic Prophylaxis: A Prospective Cohort Study On Cefazolin Utilization In Surgical Patients With Penicillin Allergy Labels, Cassius Mensah, Anvinh Nguyen, Jenny Pennycuff, Israa Shwaiki, Belle Parizot, Gary Zhang, Xiaofan Huang, Suman Rajagopalan

Faculty, Staff and Students Publications

Background: Penicillin allergy labels frequently lead to second-line antibiotics for surgical prophylaxis, due to concerns for cross-reactivity. This has led to increased patient morbidity, prolonged hospitalization, and increased healthcare costs. The most common perioperative cephalosporin, cefazolin, has unique R groups, the main antigenic portion of penicillin, which makes it safe to use in type 1 hypersensitivity penicillin allergy. We evaluated the effect of education on the incidence of the following: cefazolin usage in penicillin allergy labelled patients, allergic reactions, and surgical site infections.

Methods: As a prospective study with historical controls, perioperative clinicians were educated on the natural history of …

Single Compost Application Benefits For Organic Dryland Wheat Production, Shikha Sharma, Matt Yost, Earl Creech, Jennifer R. Reeve, Astrid R. Jacobson, Idowu Ademola Atoloye

All Current Publications

This research highlights the long-term value of compost in dryland wheat systems, where water scarcity and declining soil fertility limit productivity. A single, high-rate compost application (22 tons per acre) can improve soil moisture content, organic carbon content, aggregate stability, and microbial activity. All these benefits contributed to higher and more stable wheat yields, even more than two decades after application. These changes help to make the compost-treated wheat more resilient during dry years. While composting incurs a high upfront cost, its long-term benefits can significantly reduce the need for repeated fertilizer or soil amendments, offering cost and labor savings …

Targeting Tet3 Suppresses Group 3 Medulloblastoma Stemness And Progression Via Impairing Hypomethylation Of Otx2 Super-Enhancer, Xuan Chen, Ziwei Wang, Yan Song, Yu Su, Yahui Zhao, Jiankang Li, Wei Wang, Jiao Zhang, Craig Daniels, Xiaochong Wu, Olivier Saulnier, Yanan Wang, Fei Liu, Kaiwen Deng, Dongming Han, Zijia Liu, Meiyu Li, Liam D Hendrikse, Alexandra Rasnitsyn, Evan Y Wang, Dongyang Wang, Zhaoyang Feng, Yanong Li, Zitong Zhao, Hongyu Yuan, Youliang Sun, Yifei Jiang, Yanfeng Shi, Tao Yang, Xueling Qi, Yong Hou, Chunde Li, Yong-Qiang Liu, Yu Tian, Shuaicheng Li, Xiaoguang Qiu, Michael D Taylor, Guo Liang Li, Tao Jiang, Hailong Liu

Faculty, Staff and Students Publications

Medulloblastoma (MB), particularly Group_3 (G3-MB), remains the most aggressive subgroup due to strong stemness and therapeutic resistance. Through genome-wide DNA methylation and transcriptomic analysis of human MB samples, we identify enhancer hypomethylation as a key feature sustaining G3-MB stemness and tumor progression. Notably, hypomethylation of the Otx2 super-enhancer (SE) is a prognostic marker and potential therapeutic target for G3-MB patients. We demonstrate that disrupting Otx2 SE activity effectively reduces tumor growth in vivo, highlighting its critical role in G3-MB maintenance. TET3, recruited by OTX2, demethylates the Otx2 SE, promoting chromatin opening and sustaining tumor proliferation and stemness. To translate these …

The Role Of Religion In Ensuring National Security In Kazakhstan, Nurzhan Arystanbekuly Tursin Nur, Mukhan Issakhan, Shamshadin Kerim, Kovalev Dmitriy, Kalimash Begalinova

Occasional Papers on Religion in Eastern Europe

This article explores the foundations of state policy aimed at ensuring religious stability in Kazakhstan. It analyzes the scientific basis of religious studies, principles of tolerance toward the country’s traditional religions, and the role of religion in maintaining national security. The methodology, goals, and objectives of the study are shaped by the interdisciplinary nature of the subject. The research examines state and interfaith relations, the development of freedom of religion, its integration into domestic and international law, and ways of resolving legal contradictions, traditions, and stereotypes. The theoretical framework relies on the works of domestic and foreign scholars devoted to …

Adventism In The Ukrainian Ssr During The Post-War Period (1946–1952): Structure, Activities, And Relations With The Authorities (A Case Study Of Vinnytsia Region)., Anatoliy A. Voynarovskiy Skiy

Occasional Papers on Religion in Eastern Europe

The article contributes to the study of Adventism as a Protestant movement and examines its structure, activities, and interactions with Soviet authorities in the Ukrainian SSR during the post-war period (1946–1952). Particular attention is paid to the organizational characteristics and functioning of the Seventh-day Adventist Church (hereinafter SDA), which, among Ukrainian SSR regions, had the largest number of adherents in Vinnytsia region. In the present-day context of Ukraine’s fight for sovereignty, formation of the national church, and protection of religious freedoms for all citizens, particular attention should be paid to understanding the role of religious institutions in the development of …

Religious Communication In Ukraine's Media Space As Factor In The Formation Of Confessional Identity, Oleh Sokolovskyi, Dmytro Garaschuk

Occasional Papers on Religion in Eastern Europe

This article presents a comprehensive study within religious studies of religious periodicals in Ukraine from the early 1990s to the present. It attempts to analyze the dynamics of the emergence and transformation of printed religious mass media in the context of the democratization of social life, changes in the information environment, and the development of civil society. It is noted that religious periodicals occupy a special place within the media landscape, since they perform not only the function of conveying information but also tasks of catechesis, spiritual-educational ministry, the formation of value orientations, and the preservation of cultural-historical heritage.

The …

Orthodoxy, Culture And Language: Alaska In Russia’S Religious Diplomacy Of The 21st Century, Oleksandr Lukyanenko

Occasional Papers on Religion in Eastern Europe

The article is devoted to the analysis of the religious factor of the Russian foreign diplomacy in the light of Vladimir Putin’s high-profile visit to Alaska n August 15, 2025. The paper studies a special place of Alaska in the historical imagination of Russian political and church discourse. The status of this particular territory in Russian state worldview – the former “Russian America” – is indicative: it refers to the idea of an unfinished imperial legacy. The research doesn’t touch a main event that included a meeting with US President Donald Trump but an off-schedule meeting with Archbishop Alexei (Trader) …