Digital Commons Network^™

Functional Characterization Of Abcc8 Mutations Potentially Linked To The Transition From Hyperinsulinemic Hypoglycemia To Diabetes, Hao Zhang

McKelvey School of Engineering Graduate Student Theses & Dissertations

ATP-sensitive potassium (KATP) channels, composed of the SUR1 and Kir6.2 subunits encoded by the ABCC8 and KCNJ11 genes, are critical regulators of membrane excitability and insulin secretion in pancreatic β-cells. Gain-of-function (GOF) mutations in these genes cause neonatal diabetes mellitus through impaired insulin secretion and persistent hyperglycemia, whereas loss-of-function (LOF) mutations lead to congenital hyperinsulinism (CHI) with hypoglycemia due to β-cell hyperexcitability. I have addressed a paradoxical form of maturity-onset diabetes of the young (MODY) arising from KATP mutations, in which patients transition from CHI to glucose intolerance later in life. My experiments indicate that many KATP mutations associated with …

Postoperative Anaemia: The Unseen Challenge In Cardiac Surgery, Matthew A. Warner, Jacob Raphael

Department of Anesthesiology Faculty Papers

Postoperative anaemia is an overlooked complication of cardiac surgery that is associated with adverse clinical outcomes. Although small clinical trials suggest that postoperative treatment with i.v. iron improves haemoglobin recovery and reduces transfusion utilisation, appropriately powered randomised controlled trials are necessary to definitively evaluate the efficacy of treatment on clinical outcomes of importance to patients, clinicians, and healthcare systems. A comprehensive approach to perioperative anaemia management demands a renewed focus on both prevention and treatment to improve patient outcomes.

100 Years: The Uniform System Of Accounts For The Lodging Industry (Usali) 12th Revised Edition, Agnes Defranco, Raymond S. Schmidgall

Journal of Hospitality Financial Management

No abstract provided.

Cover And Contents

Turkish Journal of Medical Sciences

No abstract provided.

Endocrine Disruptors, Obesity, And Metabolic Syndrome, Tuğba Barlas, Alev Eroğlu Altinova, Meriç Coşkun, Ethem Turgay Ceri̇t

Turkish Journal of Medical Sciences

The global prevalence of obesity and metabolic syndrome (MetS) is rising worldwide, and increasing evidence suggests that chemical exposures—particularly endocrine disruptors (EDs)—represent a significant contributing factor. EDs can act as obesogens, increasing the risk of weight gain and related metabolic conditions, including type 2 diabetes, dyslipidemia, hypertension, and cardiovascular disease. They may also alter the basal metabolic rate, gut microbiota composition, and hormonal regulation of appetite and satiety. EDs are reported to exert their effects mainly through the peroxisome proliferator-activated receptor gamma pathway, which is primarily expressed in adipose tissue and is a key regulator of adipogenesis. Common consumer products …

Teachers’ Views About School Playtime: A Systematic Literature Review, Misbah Khan, Cathy Atkinson

International Journal of Playwork Practice

School playtime exists in varying forms across the world, and there is an extensive evidence-base pointing to its beneficial effects on children. The United Nations Convention on the Rights of the Child (UNCRC) recognises these benefits and provides clear guidance to international organisations, including schools, on protecting children’s right to play. However, legislative and societal pressures have led to teacher practices which facilitate the erosion of school playtime. Teachers’ beliefs and their practices are considered to be interlinked and therefore the aim of this systematic literature review is to consolidate existing research on teachers’ views about playtime and consider how …

Acer 2024-2025 Annual Report, Australian Council For Educational Research (Acer)

ACER Annual Reports

For more than 95 years, ACER has been driven by a single purpose – to improve learning for all. Founded in 1930, ACER began as a small team of researchers determined to bring rigour and evidence to education and assessment. Over the decades, that commitment has evolved into a global mission – combining world-class assessment and research to help learners, educators and systems understand what works in education, and why.

The Tenth Annual Report Of The American Society For Colonizing The Free People Of Colour Of The United States: With An Appendix, Tembani D. Barro Jr.

Publications and Research

The Tenth Annual Report of the American Society for Colonizing the Free People of Colour of the United States (1827) outlines the objectives, activities, and ideological foundations of the American Colonization Society during the early nineteenth century. The report details efforts to promote the relocation of free African Americans to the colony of Liberia, emphasizing arguments related to moral reform, racial coexistence, and national stability. Included financial statements, correspondence, and administrative updates document the Society’s organizational growth and political support. The appendix supplements the report with speeches and supporting documents that reflect contemporary attitudes toward race, freedom, and colonization. As …

Visible And Invisible Empires: The Revival Of The Ku Klux Klan 100 Years Ago, Christian Molina

Theses

Hatred and violence breed division, and division breeds more hatred and more violence. In an America where our politics has become name-calling, finger-pointing, scapegoating, and whataboutisms, and violence, unfortunately, it is safe to say our nation has entered this self-perpetuating cycle. A place for malicious groups concerned with growth, power, and profit to capture the angry, the stressed, and the less informed in their webs of elaborate lies and misleading, misinterpreted numbers the way they have in decades past.

On Lethality: Toward A More Complete Definition And Formation Of The Lethality Framework, John M. Hinck, Robert S. Hinck, Jayson A. Altieri, David R. Jarnot

The US Army War College Quarterly: Parameters

This article argues lethality should be conceptualized as a holistic and regenerative process in which adversarial militaries prepare for, adapt to, and sustain the application of force in conflict. Whereas the literature on lethality is widening to include the human war fighter, attempts to define and measure lethality have proven problematic—a struggle this article seeks to remedy. Drawing on historical, doctrinal, and interdisciplinary perspectives, the authors argue that lethality includes the capacity to kill and elements of learning and adaptation. The proposed lethality framework offers policy and military practitioners a model for assessing and operationalizing lethality in military education, leadership …

Using Rhizobia Seed Coatings And Soil Amendments To Combat Herbicide Toxicity For Native Legume Establishment, Ryan Matthew Glover

Theses and Dissertations

Dryland ecosystems face widespread degradation from historical mismanagement, climate change, and invasive species proliferation. Although herbicides effectively control invasive annual weeds, they often suppress the establishment of desirable perennial species, limiting restoration success. Legumes enhanced with rhizobia inoculants offer a promising approach to overcome these challenges by facilitating nitrogen fixation, improving soil microbial communities, and potentially mitigating herbicide stress. We conducted paired greenhouse and field experiments to evaluate whether rhizobia seed coatings improve the establishment of three legume species Astragalus cicer (Cicer Milkvetch), Onobrychis viciifolia (Sainfoin), and Medicago sativa (Alfalfa), in soils treated with imazapic and glyphosate. In the greenhouse, …

Evaluating The Performance Of The Primary Heat Exchanger In A Sco2 Brayton Cycle While Firing Solid Fuels, Brian Jeffrey Schooff

Theses and Dissertations

The sCO2 closed-loop Brayton cycle is an alternative to the standard steam-Rankine cycle for generating electrical power from a heat source. The sCO2 Brayton cycle is advantageous because it can be more efficient, use less water, and have smaller turbomachinery than the steam-Rankine cycle. While there are several research groups advancing the technology necessary to utilize the sCO2 Brayton cycle on an industrial scale, none of these groups use solid fuel combustion as the heat source. A Brigham Young University-led project developed and tested a pilot-scale sCO2 Brayton cycle unit (1.6 MWth) using natural gas, pulverized coal, and pulverized biomass …

Assessing Smooth Muscle Cell Death In Elastase-Treated Mouse Aortas, Bebel B. Trani

Mechanical Engineering and Materials Science Independent Study

No abstract provided.

Dnp Final Report: Hypertension Education In The Primary Care Setting, Michelle L. Sanders

DNP Final Reports

Background: Hypertension is a significant concern at the global, national, and local levels. If left untreated or improperly managed, it can result in severe health issues. Many patients in primary care settings have difficulty controlling their hypertension, which can lead to significant complications.

Practice question: What strategies can be implemented to help patients in primary care manage their hypertension more effectively?

PICOT: For patients age 18+ in a rural primary care clinic (P), how does the use of an education pamphlet (I) compared to no pamphlet use (C) affect patient management of hypertension(O) in three months? (T)

Body of …

Beyond The Standard: A Sociolectal And Probabilistic Turn In Philippine English Phonology, Teri An Joy G. Magpale

Journal of English and Applied Linguistics

This article advocates for probabilistic approaches as a key framework for understanding Philippine English (PhE) phonology, arguing that they reveal socially conditioned variation that traditional descriptive models overlook. Tracing five decades of research, it critiques early standardization efforts and studies centered on scripted speech and elite norms, and highlights the sociolectal turn initiated by Tayao (2004). The discussion foregrounds recent methods that combine instrumental phonetics with constraint-based frameworks, including Optimality Theory (OT) and Maximum Entropy grammar (MaxEnt), to model gradient variation across acrolectal, mesolectal, and basilectal speakers. By synthesizing findings on segmental features, phonotactic patterns, and speech rhythm, the article …

Top-Ranking Grammatical Keyword In Hong Kong English, Chi Wui Ng

Journal of English and Applied Linguistics

Most grammar research of Hong Kong English has been conducted from perspectives of error analysis and interlanguage studies. The present corpus-based study investigates the top-ranking grammatical keyword in Hong Kong English in relation to other English varieties to identify one-of-a-kind morphosyntactic attributes of Hong Kong English systematically. The grammatical keyword with the highest keyness in the Hong Kong component of the International Corpus of English was identified through comparison with a reference corpus comprising six other components of the corpus with the corpus analysis software WordSmith 5.0. The modal auxiliary verb “will” was identified as the top-ranking grammatical keyword in …

The Relationship Between K-12 Public School Funding, Per Pupil Expenditures, And Student Achievement, Regina R. Frazier-Bagley

Walden Dissertations and Doctoral Studies

Public school district leaders are challenged with funding K-12 education that creates the desired student academic performance. Grounded in student-based budgeting theory, this quantitative ex post facto study aimed to investigate the relationship between K–12 public school funding, per-pupil expenditures, student achievement, and graduation rates in Georgia. The study included secondary data from 51 North Georgia public school districts for the 2018–2019 school year. Multiple regression analysis was completed to examine the relationship between the independent variables—state funding, per-pupil expenditures, and academic achievement in math, science, and language arts—and the dependent variable: graduation rates. The results of the analysis were …

Employees’ Perceptions Of Leaders’ Diversity Training For Supporting Organizational Equity, Michelle L. Burchfield

Walden Dissertations and Doctoral Studies

Despite growing organizational attention to diversity, equity, and inclusion, some workplaces continued to struggle with embedding equitable practices. The research problem addressed in this study focused on understanding how employees perceived leaders’ diversity training and its effectiveness in supporting organizational equity. The purpose of this qualitative interpretative phenomenological study was to explore employees’ perspectives of leadership diversity training and its role in supporting organizational equity. Behavioral leadership theory and critical race theory grounded this study. The participants consisted of 10 employees with experience in leadership diversity training in Kentucky, Ohio, and Indiana. Data were collected using semistructured interviews. Seven most …

China’S Securitization Of Agricultural Imports: A Case Of Economic Statecraft Mixed Successes, Gustavo Ferreira, Bert Cramer

The US Army War College Quarterly: Parameters

This article argues that the People’s Republic of China’s agricultural import diversification from 1995–2023 reflects a strategic effort to reduce reliance on US and allied suppliers while prioritizing national food security. Unlike prior studies focused on production or consumption, this analysis centers on trade patterns of high-value, strategically critical commodities. Using trade data and policy documents, it assesses shifts in supplier dependency, notably toward Brazil. This research offers policy and military practitioners insights into how food security intersects with economic statecraft, revealing vulnerabilities and strategic choices in global supply chains relevant to deterrence and resilience planning.

Book Reviews, Usawc Press

The US Army War College Quarterly: Parameters

No abstract provided.

Mechanistic Roles And Design Criteria For Catalysts In Lithium–Sulfur Batteries, Saheed Lateef, Golareh Jalilvand

Faculty Publications

Catalysis is widely explored in lithium–sulfur (Li–S) batteries to address challenges related to limited capacity and cycle durability. Despite extensive research, catalyst development has often focused on materials without a clear understanding of the mechanistic landscape underlying the complex, multi-step, multi-electron sulfur redox pathway. In fact, our understanding of the thermodynamic, kinetic, and mass transport framework in Li–S systems is still evolving, particularly with respect to the reaction pathways during charge and discharge, and the dynamic evolution of materials in both liquid and solid phases. These evolving insights may fundamentally shift the requirements for catalyst design and future research priorities. …

Degrees Of Rate Control And Autodiff-Driven Direct Sensitivity Analysis In Heterogeneous Catalysis, Olajide H. Bamidele, Sina Behtash, Mubarak Bello, Andreas Heyden

Faculty Publications

Despite the wide application and benefits of the degree of rate control (DRC) analysis, several details remain argued, particularly about the conservation of DRCs at transient (TR) and steady-state (SS) conditions, especially for complex reaction networks. This work argues that previous proofs about the conservation properties of DRCs have been incomplete, and we provide new mathematical proofs at TR and SS conditions. In addition, we use both analytical (automatic differentiation) and numerical (finite difference) approaches to compute DRCs for the case study of ethane hydrogenolysis (EH) over Pt(111). This work confirms that at both TR and SS conditions, the sum …

Urinothorax And Empyema: Presentation Of An Unusual Complication Of A Rare Condition, Nolan Fox, Nicholas Fox, Shourjo Chakravorty, Neeraj Sinha

Division of Pulmonary, Allergy, and Critical Care Medicine Faculty Papers

A 68-year-old male with a history of metastatic bladder cancer and urinary obstruction presented with intractable hiccups and chest pain is presented in this case. He was found to have a unilateral pleural effusion in addition to ipsilateral renal metastasis abutting the diaphragm. Imaging revealed empyema. Thoracentesis revealed positive cultures and a lack of malignant cells on cytology. Comorbid urinary obstruction and urinary tract infection suggested the rare diagnosis of an infected urinothorax. Thoracentesis also revealed pleural fluid creatinine greater than serum creatinine, meeting the most specific diagnostic criteria for urinothorax and establishing the diagnosis. Treatment aimed at evacuating the …

Unmasking Oral Health Stigma: A Qualitative Scoping Review, J Doughty, J Booth, M Smith, K Saini, M Paisi, A Rodriguez, A Levine, C Bedos, V Muirhead, C Martins De Barros, C Freeborn

Peninsula Dental School

INTRODUCTION: Health-related stigma can limit access to care, impair adherence to treatment, and negatively impact mental health and quality-of-life. Oral health stigma, defined as stigma arising from oral conditions that diverge from sociocultural norms, operates through labelling, stereotyping, othering, and exclusion. Oral health stigma can lead to shame, diminished self-confidence, and avoidance of dental care, creating a self-perpetuating cycle of poor oral health and reinforcing internalised and anticipated stigma. While previous research has explored the social implications of oral appearance, little is known about the broader concept of oral health stigma or strategies to mitigate it.

METHODS: This scoping review …

Clinical Outcomes Of Patients With Unsuccessful Mechanical Thrombectomy Versus Best Medical Management Of Medium Vessel Occlusion Stroke In The Middle Cerebral Artery Territory, Tobias D Faizy, Vivek Yedavalli, Hamza Adel Salim, Dhairya A Lakhani, Basel Musmar, Nimer Adeeb, Muhammed Amir Essibayi, Motaz Daraghma, Kareem El Naamani, Nils Henninger, Sri Hari Sundararajan, Anna Luisa Kuhn, Jane Khalife, Sherief Ghozy, Luca Scarcia, Leonard Ll Yeo, Benjamin Yq Tan, Robert W Regenhardt, Jeremy Josef Heit, Nicole M Cancelliere, Aymeric Rouchaud, Jens Fiehler, Sunil A Sheth, Ajit S Puri, Christian Dyzmann, Marco Colasurdo, Leonardo Renieri, João Pedro Filipe, Pablo Harker, Răzvan Alexandru Radu, Mohamad Abdalkader, Piers Klein, Thomas R Marotta, Julian Spears, Takahiro Ota, Ashkan Mowla, Pascal Jabbour, Arundhati Biswas, Frédéric Clarençon, James E Siegler, Thanh N Nguyen, Ricardo Varela, Amanda Baker, David Altschul, Nestor Gonzalez, Markus A Möhlenbruch, Vincent Costalat, Benjamin Gory, Christian Paul Stracke, Constantin Hecker, Gaultier Marnat, Hamza Shaikh, Christoph J Griessenauer, David S Liebeskind, Alessandro Pedicelli, Andrea Maria Alexandre, Illario Tancredi, Erwah Kalsoum, Max Wintermark, Boris Lubicz, Aman B Patel, Vitor Mendes Pereira, Adam A Dmytriw, Adrien Guenego, Mad-Mt Investigators

Faculty, Staff and Student Publications

Background: Current randomized controlled trials are investigating the efficacy and safety of mechanical thrombectomy (MT) in patients with medium vessel occlusion (MeVO) stroke. Whether best medical management (MM) is more efficient than unsuccessful vessel recanalization during MT remains unknown.

Methods: This was a retrospective cohort study using data from 37 academic centers across North America, Asia, and Europe between September 2017 and July 2021. Only patients with occlusion of the distal branches (M2 and M3) of the middle cerebral artery territory were included. Unsuccessful MT was defined as a modified Thrombolysis in Cerebral Infarction score of 0-2a. Propensity score matching …

Cover And Contents

Turkish Journal of Veterinary & Animal Sciences

No abstract provided.

Determination Of Serum Cortisol Levels As A Stress Marker In Hospitalized Dogs, Emre Tüfekçi̇, Gencay Eki̇nci̇, İlknur Karaca Bekdi̇k, Ali̇ Cesur Onmaz, Öznur Aslan, Vehbi̇ Güneş, İhsan Keleş, Mehmet Çi̇ti̇l

Turkish Journal of Veterinary & Animal Sciences

In veterinary medicine, various diseases and surgical procedures may require the isolation and hospitalization of dogs, allowing for more effective individual patient monitoring and increasing the chance of successful treatment by preventing unnecessary drug use. However, this process can be stressful. Our study aimed to determine the changes in cortisol levels, one of the primary stress hormones responsible for stress responses, in individually hospitalized dogs. In addition, epinephrine (EPN) levels, another stress marker, as well as hematological and some biochemical values were measured and vital signs were recorded. The dogs included in the study were divided into 3 groups: healthy, …

Endocrine-Disrupting Chemicals And Thyroid Cancer, Özge Baş Aksu, Mustafa Şahi̇n

Turkish Journal of Medical Sciences

Environmental endocrine-disrupting chemicals (EDCs) have emerged as a critical global health concern because of their role in various diseases, including thyroid cancer. Defined as exogenous substances that disrupt endocrine system functions, EDCs can affect multiple generations through mechanisms such as hormone receptor modulation, altered hormone synthesis, and epigenetic modifications.The increasing global incidence of thyroid cancer has heightened interest in environmental factors, with EDC exposure recognized as a significant contributor. Compounds such as heavy metals, persistent organic pollutants, per- and polyfluoroalkyl substances, and bisphenol A play crucial roles in disrupting thyroid homeostasis. Emerging evidence underscores the synergistic effects of multiple EDC …

Enhancing Aerosol Scattering Measurements: Performance Evaluation And Quality Assurance Of Airphoton Integrating Nephelometers In The Surface Particulate Matter Network, Kamlendra Singh Pathak

McKelvey School of Engineering Graduate Student Theses & Dissertations

Integrating nephelometers are key instruments for quantifying aerosol light scattering, a fundamental parameter governing the direct radiative effect of aerosols on climate and visibility, and for interpreting satellite observations of aerosol optical depth. The AirPhoton integrating nephelometer quantifies aerosol light scattering by measuring total scattering from the sample air and subtracting a clean-air reference that represents Rayleigh scattering, instrument wall scattering, and detector background noise. Measurement accuracy depends on rigorous calibration and regular performance evaluation to account for instrumental drift and environmental influences. This study presents a field performance evaluation of the AirPhoton integrating nephelometer within the global Surface Particulate …

Integrating Large Language Models And Single-Cell Omics Analysis For Target Discovery In Pancreatic Ductal Adenocarcinoma, Zixi Xu

McKelvey School of Engineering Graduate Student Theses & Dissertations

The elucidation of cell-type–specific signaling networks is central to understanding pancreatic ductal adenocarcinoma (PDAC) and to nominating mechanistically grounded therapeutic targets. We present a Text-to-Target framework that integrates large language models (LLMs) with single-cell omics to couple literature-derived hypotheses to cell-type–resolved expression evidence. Using publicly available datasets, we construct malignant ductal epithelial and lineage-matched acinar meta-cell cohorts from PDAC and perform differential expression analysis to obtain a robust catalogue of disease-associated transcriptional changes. In parallel, an ensemble of LLMs is prompted in a schema-constrained manner to retrieve cell-type–specific targets, pathways, and mechanistic annotations from the biomedical literature. After normalization and …