Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (8661)
- Social and Behavioral Sciences (6674)
- Arts and Humanities (6312)
- Education (4659)
- Medical Specialties (3908)
-
- Medical Sciences (3781)
- Life Sciences (3084)
- Physical Sciences and Mathematics (2705)
- Law (2231)
- Engineering (1922)
- Psychology (1678)
- Public Health (1580)
- English Language and Literature (1373)
- Religion (1346)
- Computer Sciences (1303)
- Sociology (1196)
- Business (1151)
- Biomedical Informatics (1095)
- History (1085)
- Medical Genetics (1011)
- Nursing (993)
- Higher Education (977)
- Public Affairs, Public Policy and Public Administration (931)
- Oncology (916)
- Genetic Phenomena (912)
- Bioinformatics (841)
- History of Art, Architecture, and Archaeology (716)
- Diseases (704)
- Creative Writing (697)
- Communication (675)
- Institution
-
- The Texas Medical Center Library (4007)
- University of Texas at Arlington (2303)
- Singapore Management University (1261)
- City University of New York (CUNY) (1110)
- Thomas Jefferson University (1020)
-
- University of South Carolina (957)
- University of South Florida (949)
- Liberty University (902)
- Brigham Young University (884)
- Missouri University of Science and Technology (830)
- Israel Antiquities Authority (604)
- University of Central Florida (529)
- Washington University in St. Louis (496)
- University of Arkansas, Fayetteville (490)
- Walden University (468)
- Portland State University (463)
- University of Nevada, Las Vegas (449)
- University of New Mexico (448)
- University of Montana (413)
- Chulalongkorn University (341)
- University of Plymouth (327)
- Edith Cowan University (306)
- Purdue University (306)
- Arkansas State University (305)
- Syracuse University (303)
- St. Mary's University (301)
- Nova Southeastern University (287)
- Grand Valley State University (257)
- University at Albany, State University of New York (244)
- Case Western Reserve University (238)
- Keyword
-
- Humans (2761)
- Female (1782)
- Male (1679)
- Middle Aged (944)
- Adult (914)
-
- Animals (848)
- Aged (741)
- Mice (566)
- Education (381)
- English (381)
- United States (378)
- Child (368)
- Adolescent (359)
- Artificial intelligence (295)
- Young Adult (286)
- Mental health (274)
- COVID-19 (263)
- Retrospective Studies (259)
- Treatment Outcome (242)
- Machine learning (228)
- Preschool (201)
- Biomarkers (197)
- Higher education (197)
- Tumor (197)
- Infant (195)
- Aged, 80 and over (194)
- Child, Preschool (194)
- Inbred C57BL (187)
- 80 and over (185)
- Mice, Inbred C57BL (185)
- Publication
-
- Faculty, Staff and Students Publications (1876)
- Faculty, Staff and Student Publications (1755)
- Theses and Dissertations (1462)
- The Shorthorn Newspaper Collection: 1970s (659)
- 'Atiqot (592)
-
- Research Collection School Of Computing and Information Systems (584)
- Faculty Publications (550)
- Doctoral Dissertations and Projects (539)
- Walden Dissertations and Doctoral Studies (425)
- Electronic Theses and Dissertations (373)
- Faculty Scholarship (353)
- Dissertations (324)
- The Shorthorn Newspaper Collection: 1930s (320)
- Marine Ornithology (301)
- The Shorthorn Newspaper Collection: 1940s (289)
- Dissertations, Theses, and Capstone Projects (280)
- Research outputs 2022 to 2026 (268)
- Open Educational Resources (264)
- The Shorthorn Newspaper Collection: 1920s (261)
- University of Montana Course Syllabi, 2021-2025 (249)
- Dissertations and Theses (238)
- Publications and Research (230)
- The Shorthorn Newspaper Collection: 1950s (220)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (216)
- Electronic Theses & Dissertations (2024 - present) (207)
- Executive Council Minutes (206)
- Honors Theses (201)
- UNLV Theses, Dissertations, Professional Papers, and Capstones (201)
- Graduate Thesis and Dissertation post-2024 (199)
- Honors Undergraduate Theses (199)
- Publication Type
Articles 811 - 840 of 41322
Full-Text Articles in Entire DC Network
Emotions As Work Material: On Dancers' Refined Use Of Affectivity, Camille S. Buttingsrud
Emotions As Work Material: On Dancers' Refined Use Of Affectivity, Camille S. Buttingsrud
Duquesne Studies in Phenomenology
As part of their professional practice, dancers allow their affectivity to enhance their kinesthetic work. Their intentional and disciplined use of personal, emotional resources ensures both creativity, interpretation, absorption, and connections in ways that extend beyond the traditional phenomenological understanding of affectivity as pre-reflectively based. The affective regulations dancers employ can be seen as an “artistic epoché,” and their layered performance awareness corresponds with Edmund Husserl’s descriptions of “image-consciousness.” Through qualitative interviews with three professional dancers, phenomenological theory, and additional supportive literature, this article shows how affectivity can be experienced through high-order levels of Leib, constituting states of “bodily …
With Images In Time. Atmosphere And Art: Mediation And Dialogue, Pauline Von Bonsdorff
With Images In Time. Atmosphere And Art: Mediation And Dialogue, Pauline Von Bonsdorff
Duquesne Studies in Phenomenology
The article challenges the idea that atmospheres are always sensed immediately. Instead, atmospheres in art are mediated and arise in a dialogue between work and audience. To understand how, we should pay attention to temporal structures in and around the work, such as the dynamics and duration of aesthetic experience and the historicity of both work and perceiver, including pasts and present. Mikel Dufrenne’s phenomenological aesthetics, complemented with insights from Maurice Merleau-Ponty’s analyses of perception, offer resources for this. Writing on expression, Dufrenne distinguishes “presence,” in which sense is felt immediately and firmly connected to embodiment, and “sentiment,” which arises …
Rapture "At A Distance": Searching For Pathic-Atmospheric Aesthetics, Tonino Griffero
Rapture "At A Distance": Searching For Pathic-Atmospheric Aesthetics, Tonino Griffero
Duquesne Studies in Phenomenology
The paper proposes a rethinking of the role of aesthetics as a theory of sensory experience as it is encountered in the lifeworld (and only secondarily in relation to art). Accordingly, pathic and atmospheric (bottom-up) aesthetics, which centers on the ability to expose oneself to intense experiences without attempting to control them and conceives feelings as atmospheric powers that permeate a particular space without being reduced to projections of the perceiver’s moods, should replace the idealistic (top-down) approach.
Lutheran Music And The Thirty Years War: Confession, Politics, Devotion, Thomas Marks
Lutheran Music And The Thirty Years War: Confession, Politics, Devotion, Thomas Marks
Yale Journal of Music & Religion
A book review is presented for Lutheran Music and the Thirty Years War: Confession, Politics, Devotion, authored by Derek L. Stauff, by Thomas Marks.
Byzantine Theories Of Scale And Arab-Byzantine Chant Practices: A Comparative Analysis Proposing A New Resolution To The Theoretical System Of Chrysanthos Of Madytos, Rosy Azar
Yale Journal of Music & Religion
In 2015, Amine Beyhom published a book on Byzantine chant, in which he summarised all the existing theories, paying particular attention to the problematic reform of the Byzantine chant theory in 1881, and guiding the reader through the steps that led to that reform. Driven by the first ever comparison between Byzantine and Arabic modes that he had found in Mīkhāʾīl Mashāqa’s epistle, Beyhom first studied Chrysanthos of Madytos’ insight. He documented this research in detail and followed it with a practical comparison to demonstrate if theory is indeed applied or it acts only as prescriptive guide. He recorded and …
Olivier Messiaen’S "Première Communion De La Vierge" And The Translation Of Religious Meaning, Robert Sholl, Jean-Rodolphe Kars
Olivier Messiaen’S "Première Communion De La Vierge" And The Translation Of Religious Meaning, Robert Sholl, Jean-Rodolphe Kars
Yale Journal of Music & Religion
This study creates a rich exegesis of “Première Communion de la Vierge” from Olivier Messiaen’s (1908–1992) piano cycle Vingt Regards sur l’Enfant-Jésus (1944) to show how Messiaen attempted to translate musical symbolism into religious meaning. The first two sections provide background and context on the work, revise previous scholarship, and show how this piece (no XI) functions as a theological hinge in the cycle. The genesis and sources of the Vingt Regards, using previously unavailable archival material, are examined to provide new insight into both the cycle and the “Première Communion.” The aesthetic scaffolding of this piece is then …
Article Draft, Bob Schieffer
Article Draft, Bob Schieffer
Bob Schieffer Vietnam War Collection
Bob Schieffer's notes of events that occured during a battle in Vietnam.
Article Draft, Bob Schieffer
Article Draft, Bob Schieffer
Bob Schieffer Vietnam War Collection
Article draft by Bob Schieffer about the Vietnamese dislike of Americans in Vietnam.
Two Years Of Iqts: Its Current State, And Implications For English Itt By Distance Learning, Oliver C S Au Yeung
Two Years Of Iqts: Its Current State, And Implications For English Itt By Distance Learning, Oliver C S Au Yeung
Plymouth Interdisciplinary Education Open Journal
International qualified teacher status (iQTS), a new programme which enables candidates to qualify while teaching overseas, marks one of the latest major developments in England’s teacher training system. This study endeavours to survey its current state and make an assessment of the nature of its training. The literature review situates the programme in the historical trajectory of English initial teacher training (ITT) and, in turn, the higher education and socio-economic contexts. As an analytic framework, Furlong’s fourfold categorisation of teachers’ knowledge is used to represent competing approaches to teacher training. It is argued that the liberal approach, emphasising a broad, …
Post Traumatic Stress Disorders Within The Hmong Community, Keng Moua
Post Traumatic Stress Disorders Within The Hmong Community, Keng Moua
Master of Arts in Human Services
The paper will provide an overview of who the Hmong folks are, the history of PTSD as well as some background knowledge of the mental health, and comparing them together. This paper will also dive a bit deeper to explore more about mental health in the Hmong community.
Chad Dobson Reflects On The Launch Of The World Bank Reform Campaign, Chad Dobson, Julie Radomski
Chad Dobson Reflects On The Launch Of The World Bank Reform Campaign, Chad Dobson, Julie Radomski
Perspectives
Chad Dobson is the founder of the Bank Information Center (BIC) and led BIC from 1987 to 1997 and 2007 to 2016. He is widely accredited with developing the global campaign strategies for environmental and social reforms of multilateral development banks (MDB). In this interview, he recounts the early days of BIC and the development of the global campaign.
Enhancing Readiness Of Novice Nurse Educators To Use Concept Mapping As An Active Learning Strategy, Kaitlyn Dutch
Enhancing Readiness Of Novice Nurse Educators To Use Concept Mapping As An Active Learning Strategy, Kaitlyn Dutch
MSN Student Capstones
No abstract provided.
Exploring The Impact Of Inpatient Mental Health Care On Adolescents, Alexandria M. Mckahan
Exploring The Impact Of Inpatient Mental Health Care On Adolescents, Alexandria M. Mckahan
2025 Fall Honors Capstones Projects - Archive
Adolescent psychiatric hospitalizations continue to rise, yet there is limited research on which daily practices inside inpatient units genuinely support engagement and recovery. This project examined how structure, staff tone, and therapeutic programming influence adolescents’ participation and emotional stability within a real inpatient setting. The study focused on three questions: how structured routines affect recovery, what challenges staff face when supporting adolescents with complex needs, and how adolescents’ engagement patterns reflect their perception of care. Using a mixed-methods case study at Mesa Springs Behavioral Health Hospital, I conducted approximately twenty field observations, semi-structured staff interviews, and descriptive engagement tracking across …
Examining The Role Of Early Bilingualism On Interference Suppression And Prefrontal Connectivity, Matthew L. Cook, Lisa K. Boyce, Allison S. Hancock, Mackenzy S. Turner, Spencer D. Bradshaw
Examining The Role Of Early Bilingualism On Interference Suppression And Prefrontal Connectivity, Matthew L. Cook, Lisa K. Boyce, Allison S. Hancock, Mackenzy S. Turner, Spencer D. Bradshaw
Human Development and Family Studies Student Research
Inhibitory control is a core cognitive function that is primarily associated with activation in the prefrontal cortex (PFC) and is the cognitive function that inhibits impulses, thoughts, and suppresses irrelevant information to an identified goal or task. Prior research suggests that bilingualism may affect brain activity related to inhibitory control, yet few studies have compared functional activity between monolingual and bilingual children. The current study used functional near-infrared spectroscopy (fNIRS) to examine region of interest comparisons and task-state functional connectivity across the PFC during an interference suppression Simon task with 13 bilingual (East Asian or Ibero-romance paired with English) and …
Kuleana Mākua: Native Hawaiian Parents' Exercise Of Agency In K-12 School Selection, Joseph Piikeha Kahaka`Ulamaikalaniki`Eki`E Hao
Kuleana Mākua: Native Hawaiian Parents' Exercise Of Agency In K-12 School Selection, Joseph Piikeha Kahaka`Ulamaikalaniki`Eki`E Hao
Theses and Dissertations
In this qualitative study the author investigates how Native Hawaiian parents on Hawai`i Island navigate educational choices for their children amidst a history of centralized, Western-dominated schooling and systemic cultural suppression. Grounded in Bandura’s Social Cognitive Theory (SCT), the research explores parent perceptions of different K–12 school types and the complex factors that drive their selection. Through semi-structured interviews and a card sort activity with sixteen Native Hawaiian parents (n = 16), the study confirms that parental choice is fundamentally an act of indigenous self-determination defined by Kuleana Mākua (parental responsibility, authority, and privilege). The findings reveal that parents’ choices …
Cv: Bruce Law (Educational Leadership), Bruce Law
Cv: Bruce Law (Educational Leadership), Bruce Law
Education Department Faculty Curricula Vitae
No abstract provided.
An Analysis Of Ukrainians' Language Attitudes And Ideology: A Conflict-Catalyzed Language And Identity Shift, Kateryna Kravchenko
An Analysis Of Ukrainians' Language Attitudes And Ideology: A Conflict-Catalyzed Language And Identity Shift, Kateryna Kravchenko
Theses and Dissertations
On February 24, 2022, the Russian Federation invaded Ukraine. According to Vladimir Putin's speech, the main goal of the war was to protect the Russian-speaking population of the Donbas region in eastern Ukraine. Many Ukrainians indeed speak Russian on a daily basis, largely due to the long and complicated history between the two countries. Recently, there has been an increase in pro-Ukrainian ideologies (Kulyk 2016); however, as the full-scale invasion began, people started advocating for Ukrainian usage in all public domains, and many even vowed to never speak Russian again. Since then, there has been a profound change in language …
Enhancing Silicon Sampling In Large Language Models: Fine-Tuning Techniques Using Survey Data, Davis P. Forster
Enhancing Silicon Sampling In Large Language Models: Fine-Tuning Techniques Using Survey Data, Davis P. Forster
Theses and Dissertations
Large language models (LLMs) are increasingly used to simulate responses of human demographic groups, a task known as silicon sampling. This paper investigates whether supervised fine-tuning can improve algorithmic fidelity in such settings. We construct a dataset from the General Social Survey (GSS), converting demographic attributes into natural-language backstories and randomly selecting one attribute as a held-out target. Fine-tuning a LLaMA-3.1-70B model on this dataset yields significant improvements on two tasks: (1) imputing missing attributes at the individual level, and (2) reproducing response distributions for demographic slices, such as racial and age groups. Notably, these improvements are achieved with minimal …
Integrating Chatgpt Voice To Enhance German Language Communication, Michael B. Dettinger
Integrating Chatgpt Voice To Enhance German Language Communication, Michael B. Dettinger
Teaching Repository of AI-Infused Learning
In this course, students were required to write four essay topics, and in turn were assigned to use ChatGPT Voice in a task prior to each essay in order to assist them in framing their argument, as well as to practice working through their essay and presentation topic verbally in advance.
Cyber-Physical Framework For Smart Paint Manufacturing: Hybrid Integration Of Plc And Recipe Management Simulation, Stephen A. Michael, Anas M. Atieh, Emmanuel Nkwocha, Nathir A. Rawashdeh
Cyber-Physical Framework For Smart Paint Manufacturing: Hybrid Integration Of Plc And Recipe Management Simulation, Stephen A. Michael, Anas M. Atieh, Emmanuel Nkwocha, Nathir A. Rawashdeh
Michigan Tech Publications
This study investigates the implementation of Industry 4.0 paradigms in the context of smart paint manufacturing, focusing on process control and recipe management through the integration of Ignition SCADA, a Siemens programmable logic controller (PLC), and a MySQL Workbench database. The developed architecture employs Ignition as an interoperable communication interface that facilitates bidirectional data exchange between the PLC and the database, thereby establishing a cyber-physical system for automated monitoring and control. The digital recipe management module formalizes paint formulations into parameterized datasets specifying paint and solvent ingredient ratios, process variables, and operational constraints, which are executed autonomously by the control …
Discourse, Power, And Pedagogy In Ai And Human-Designed Efl Lesson Plans: A Clil And Systemic Functional Linguistic Perspective, Christian D. Libunao, Vincent A. Morales
Discourse, Power, And Pedagogy In Ai And Human-Designed Efl Lesson Plans: A Clil And Systemic Functional Linguistic Perspective, Christian D. Libunao, Vincent A. Morales
Journal of English and Applied Linguistics
The integration of generative artificial intelligence (GAI) into English language teaching (ELT) raises important questions about how AI-generated lesson plans shape pedagogy, interaction, and ideology compared to human-designed materials. This study examines how ChatGPT-generated lesson plans converge with or diverge from those published by the British Council, with particular attention to teacher and learner roles, classroom power dynamics, and pedagogical scaffolding. A triadic framework combining systemic functional linguistics (SFL), critical discourse analysis (CDA), and content and language integrated learning (CLIL) was applied to three British Council lesson plans and three thematically matched ChatGPT outputs. Findings reveal that both sets of …
Framing Of Immigration In The News And Its Effects On Social Media Discourse On The Southcoast Of Massachusetts, Mariel Surprenant
Framing Of Immigration In The News And Its Effects On Social Media Discourse On The Southcoast Of Massachusetts, Mariel Surprenant
Political Science Undergraduate Theses
Why do immigrant communities often express anti-immigrant sentiment? This study will focus on examining what political discourse about immigration dominates the news ecosystem of the Southcoast of Massachusetts, and what effect that discourse has. Immigration in the U.S. has become an increasingly politicized issue, dominating political discourse, motivating voter behavior, and shaping regional political identities. This study will use content analysis of Southcoast newspapers to examine how the local news frames immigration and discourse analysis to examine the opinions of everyday citizens revealed as by their social media comments on posts about immigration by the same local news sources. The …
Exercise And Its' Impact On Student's Mental Health, Braden Wolf
Exercise And Its' Impact On Student's Mental Health, Braden Wolf
Psychology Student Publications
This paper examines how exercise positively impacts the mental health of college students, a group especially vulnerable to mental health challenges. It reviews empirical evidence showing that exercise improves self-efficacy, reduces negative emotions, and lowers suicide risk by enhancing confidence, sleep, academic success, and reducing depression, anxiety, and stress. While exercise is not a complete solution to mental health issues, it can significantly alleviate symptoms and prevent further distress.
Enhancing English Literacy Through Task-Based Learning In A Technology-Integrated Classroom, Yueh-Tzu Chiang
Enhancing English Literacy Through Task-Based Learning In A Technology-Integrated Classroom, Yueh-Tzu Chiang
Journal of English and Applied Linguistics
This study explored the impact of task-based teaching in a technology-enhanced environment, following the blended ladder model (Gravel et al., 2014), on second language (L2) learners’ English reading and writing skills. The study aimed to promote reading habits through extensive reading (ER), improve language skills via technology-assisted platforms (e.g., ZUVIO and Classdojo), and reduce writing anxiety. Two classes of 40 students each were divided into higher proficiency (HP) and lower proficiency (LP) groups for an eight-week intervention. Both classes participated in two interventions: self-selected reading materials with reading journals and task-based learning involving grammar, sentence structure, and authentic writing tasks …
Ecolinguistic Analysis Of Princess Mononoke: Boosting Environmental Literacy, Aditya Alam Soeta Bangsa, George M. Jacobs, Ingrid A. Gavilán Tatin
Ecolinguistic Analysis Of Princess Mononoke: Boosting Environmental Literacy, Aditya Alam Soeta Bangsa, George M. Jacobs, Ingrid A. Gavilán Tatin
Journal of English and Applied Linguistics
The Anthropocene is a term some scientists use for the current geological age, during which human activities profoundly and often negatively impact Earth’s systems, including environmental change. Despite widespread recognition of this global crisis, a gap persists between awareness and meaningful action, underscoring a critical deficit in environmental literacy. This study aims to address this gap by conducting an ecolinguistic analysis of Hayao Miyazaki’s (1997) film, Princess Mononoke. Stibbe’s (2020) Stories We Live By, particularly the story of ideology, was used to analyze the film and its five principal human characters, examining their attitudes and behavior, and connecting …
Discursive And Ideological Issues Foregrounding The Attitudinal Conceptualization Of Yahoo Yahoo (Internet Fraud) In Selected Nigerian Comedy Skits, Temitope Michael Ajayi, Aishat Lare Husseini
Discursive And Ideological Issues Foregrounding The Attitudinal Conceptualization Of Yahoo Yahoo (Internet Fraud) In Selected Nigerian Comedy Skits, Temitope Michael Ajayi, Aishat Lare Husseini
Journal of English and Applied Linguistics
Cybercrime, Yahoo Yahoo in the Nigerian context, has emerged as one of the major issues the global space is currently facing, and as such has received scholarly attention, mostly from the sociological, anthropological, and legal perspectives, but very scant attention from linguistics. From alinguistic perspective, this study thus investigates the discursive-ideological issues foregrounding Nigerians’ attitudinal orientation towards Yahoo Yahoo (Internet Fraud) as portrayed in selected Nigerian comedy skits. Data comprised four purposively selected comedy skits by Lasisi Elenu and Prince Tgb downloaded from their social media pages (YouTube and TikTok). With analytical insight from van Dijk’s socio-cognitive model of ideology, …
Beliefs And Practices Of Filipino Bilingual Senior High School Students On Language Learner Autonomy, Japhet E. Manzano, Zachi Einna R. Orquijo, Giovanni C. Duran
Beliefs And Practices Of Filipino Bilingual Senior High School Students On Language Learner Autonomy, Japhet E. Manzano, Zachi Einna R. Orquijo, Giovanni C. Duran
Journal of English and Applied Linguistics
The concept of learner autonomy (LA) has been investigated mostly from the perspective of language teachers, whereas students’ views regarding this notion have received less attention in recent decades. In line with this, the present study aimed to examine the beliefs and practices of Filipino bilingual senior high school students enrolled in the Humanities and Social Sciences (HumSS) and Science, Technology, Engineering, and Mathematics (STEM) strands. A total of 148 students from two Philippine public schools in Metro Manila participated in an adapted survey questionnaire containing Likert-scale items on beliefs, desirability, and feasibility of LA, along with an open-ended question …
Faith’S Midwest Modern Forms: Midcentury Catholic Churches In St. Louis By Murphy And Mackey, Architects, Mary Reid Brunstrom
Faith’S Midwest Modern Forms: Midcentury Catholic Churches In St. Louis By Murphy And Mackey, Architects, Mary Reid Brunstrom
Arts & Sciences Graduate Student Theses and Dissertations
This project originated in my research on three modernist churches commissioned by the Catholic Archdiocese of St. Louis from 1948-54 which was then under the progressive leadership of Archbishop (later Cardinal) Joseph E. Ritter. What factors accounted for these unprecedented forms for sacred architecture? The architectural partnership of Murphy and Mackey designed the churches in accordance with the new liturgical reform protocols that were embedded in the designs of the German architect, Rudolf Schwarz and his colleagues and disseminated through Catholic pastors of German origin in the St. Louis parishes. Other strands of modernism were also implicated in Murphy and …
The Effect Of Talker Intelligibility On Adaptation And Generalization To An Unfamiliar Accent, Kaitlyn L. Matthews
The Effect Of Talker Intelligibility On Adaptation And Generalization To An Unfamiliar Accent, Kaitlyn L. Matthews
Arts & Sciences Graduate Student Theses and Dissertations
Hearing unfamiliar second language (L2) accented speech reduces intelligibility (i.e. accuracy of speech understanding) and increases the listening effort (i.e. deliberate allocation of cognitive resources) required to process the speech. However, listeners readily adapt to L2-accented speech, improving intelligibility and reducing listening effort. The type of exposure that may lead to lower listening effort when generalizing knowledge to a new speaker of the same accent has yet to be explored. We exposed native English speakers to English sentences spoken by native English speakers, highly intelligible Mandarin Chinese-accented English speakers, or less intelligible Mandarin Chinese-accented English speakers. While measuring pupil dilation …
Optimization Of Research Pipeline To Characterize The Effects Of Atp-Sensitive Potassium Channels Mutations On Native Skeletal Muscle Fibers And Evaluate Potential Drug Therapy, Yuezhou Chen
McKelvey School of Engineering Graduate Student Theses & Dissertations
The ATP-sensitive potassium (KATP) channel is a critical metabolic sensor in skeletal muscle, yet its definitive molecular composition and functional roles remain contested. In this study, I conclusively demonstrate that the Kir6.2/SUR2 complex forms sarcolemmal KATP channel in mouse fast-twitch muscle. Genetic knock-out (KO) of Kir6.2 (Kcnj11−/−) or SUR2 (Abcc9−/−) resulted in a similar phenotype with increased fatigue resistance and a pathological rise in unstimulated resting tension at high-frequency stimulation. In contrast, SUR1 (Abcc8−/−) KO was ineffective. Furthermore, a CRISPR/Cas9 knock-in mouse model of a human SUR2A truncation variant (KCGV/KCGV) recapitulated the abnormal force accumulation, demonstrating that even loss-of-function of …