Digital Commons Network^™

Perceived Parental Relationship Quality And Adolescent Conscious Bias: Important Links Between Affect, Agency, Gender, And Race/Ethnicity, Amanda Terrall, Michael J. Merten, Thulitha Wickrama

General Human Environmental Sciences Faculty Publications and Presentations

Introduction Guided by attachment, social cognitive, and ecological systems theories, this study examined the direct and indirect effects of perceived parent-adolescent relationship quality on youths' conscious bias toward individuals facing socioeconomic or minority-related challenges.Methods Data were collected from 702 U.S. 18-year-olds via Qualtrics online panels. Measures included parent relationship quality, negative affect, human agency, and conscious bias (disregard for minority experiences and blaming attitudes).Results The findings revealed that strong parent-teen bonds indirectly influenced conscious bias through psychosocial wellbeing. However, while negative emotions were universally influential, the impact of human agency varied depending on gender and race/ethnicity.Discussion Study findings underscore the …

Physician Peer Review: Just Culture And Practical Implementation In An Emergency Department, Christian Fromm, Monica Colicino, Merle A. Carter, Elizabeth M. Datner

Einstein Health Papers

BACKGROUND: Although regulatory agencies require hospitals to engage in peer review to maintain accreditation, quality assurance review processes are not standardized, and well-structured peer review of clinical cases involving medical errors and adverse events governed by Just Culture principles is not widespread. We implemented such an emergency department (ED) physician peer review process and performed an analysis of cases that underwent review.

METHODS: We formed an ED physician peer review committee at our institution guided by Just Culture principles, including promotion of a culture of safety to encourage open reporting of errors and near misses, and top-down leadership commitment to …

The Mechanism Of Action Of Remote Electrical Neuromodulation (Ren) In Treating Migraine And Potentially Other Idiopathic Pain Conditions, Marius Birlea, Christopher L. Robinson, Eden Mama, Alit Stark-Inbar, Alon Ironi, Daniel Atashsokhan, Thomas Berk

College of Nursing Faculty Papers & Presentations

Purpose of Review

This review provides evidence for the mechanism of action (MOA) of Remote Electrical Neuromodulation (REN), a non-pharmacological therapeutic technology for treating migraine and other symptoms manifested by certain idiopathic pain diseases. It discusses the main physiological and anatomical aspects associated with conditioned pain modulation (CPM), and how REN is applied for the treatment of migraine pain and other symptoms.

Recent Findings

The REN wearable device (Nerivio®) is FDA cleared for acute and preventive treatment of migraine in patients aged 8 years and above, and CE marked in patients aged 12 and above. In brief, the REN MOA …

A Phase 1/2 Study Of Ds-1594 Menin Inhibitor In Relapsed/Refractory Acute Leukemias, Jayastu Senapati, Marina Konopleva, Ghayas C Issa, Elias Jabbour, Tapan Kadia, Courtney Dinardo, Gautam Borthakur, Naveen Pemmaraju, Nicholas J Short, Musa Yilmaz, Indraneel Deshmukh, Joie Alvarez, Sanam Loghavi, Guilin Tang, Hussein A Abbas, Michael Andreeff, Kapil Bhalla, Narasimha M Midde, Nabil Said, Amy Noyalis, Derek E Mires, Jing Ning, Lianchun Xiao, Farhad Ravandi, Guillermo Garcia-Manero, Hagop M Kantarjian, Naval G Daver

Faculty, Staff and Student Publications

Several menin inhibitors are in development targeting menin dependent leukemias, however available preclinical results show variable level of activity. We report the phase 1 portion (to establish a recommended phase 2 dose [RP2D]) and pharmacokinetic analysis of a phase 1/2 first-in-human clinical trial of DS-1594b menin inhibitor. Eligible patients included adults (≥ 18 years of age) with relapsed/refractory (R/R) acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) including but not restricted to those with KMT2A-rearrangement (r) or NPM1 mutation. Seventeen patients at a median of age 56 years (range, 19-82 years) were treated, 15 (88%) had R/R AML, and …

Apocalypticism And Prognostication In Early ShiʿI Literature, Mohammad Amin Mansouri

All Faculty Scholarship for the College of Arts and Humanities

This article studies the origins of Jafr, an apocalyptic, eschatological and occult book attributed to the first Shiʿi imam, ʿAlī ibn Abī Ṭālib (d. 661). While it remains unclear whether Jafr was ever physically composed, it became associated with lettrism (ʿilm al-ḥurūf) in medieval Sunni and Shiʿi literature. Jafr gradually evolved into a crucial component of Islamic occult traditions and influenced various cosmological theories as well as the letter-magic practices of prominent Sunni and Shiʿi occultists. Despite its historical significance, confusion regarding Jafr’s roots, authorship and content in Shiʿi sources from the third to fifth centuries AH …

Brain Power Comparison Between Microgravity And Head-Down Tilt Bed Rest: An Electroencephalography Approach, María Sevilla-García, Adrián Quivira-Lopesino, Pablo Cuesta, Sandra Pusil, Ricardo Bruña, Patrique Fiedler, Fernando Maestu, Ana Maria Cebolla, Guy Cheron, Katharina Brauns, Alexander C Stahn, Michael E Funke

Faculty, Staff and Student Publications

This study examines neurophysiological changes in microgravity by comparing EEG data from two ground analog 60-day head-down tilt bed rest (HDBR) experiments (ESA/DLR “Cocktail” and “RSL”) and the NEUROSPAT experiment in space. The primary objective was to determine whether HDBR could effectively model spaceflight’s impact on the human brain’s EEG signal. In the HDBR dataset, increases in relative delta (2–4 Hz) (p <  0.01) and theta (4–8 Hz) (p <  0.001) power bands were observed during a two-month HDBR experiment, predominantly in the left temporal and parieto-occipital regions. Conversely, the NEUROSPAT dataset showed a significant increase in beta (12–30 Hz) (p <  0.05) power in the left somatosensory cortex during in-flight conditions, suggesting a potential adaptation to disrupted proprioceptive input and motor control in microgravity. The contrasting findings between the two datasets indicate that while HDBR can simulate some aspects of microgravity, it may not serve as a model for all central nervous system changes, especially those related to proprioception and motor functions. This highlights the need for further research, including larger sample sizes, consistent EEG recording conditions, and integration of additional physiological and cognitive markers to fully understand the effects of prolonged microgravity.

Accelerating Digital Mental Health: The Society Of Digital Psychiatry's Three-Pronged Road Map For Education, Digital Navigators, And Ai, John Torous, Kathryn Taylor Ledley, Carla Gorban, Gillian Strudwick, Julian Schwarz, Soumya Choudhary, Margaret Emerson, Michelle Patriquin, Allison Dempsey, Jason Bantjes, Laura Ospina-Pinillos, Jennie Hornick, Shruti Kochhar

Faculty, Staff and Student Publications

Digital mental health tools such as apps, virtual reality, and artificial intelligence (AI) hold great promise but continue to face barriers to widespread clinical adoption. The Society of Digital Psychiatry, in partnership with JMIR Mental Health, presents a 3-pronged road map to accelerate their safe, effective, and equitable implementation. First, education: integrate digital psychiatry into core training and professional development through a global webinar series, annual symposium, newsletter, and an updated open-access curriculum addressing AI and the evolving digital navigator role. Second, AI standards: develop transparent, actionable benchmarks and consensus guidance through initiatives like MindBench.ai to assess reasoning, safety, and …

Improving Diagnostic Accuracy In Preoperative Glioma Classification: Performance Of Knowledge-Enhanced Large Language Models Compared With Radiologists, Shuang Li, Xin Fang, Yuqi Jin, Yujiao Deng, Wei Hu, Bing Wu, Xiaobo Zhou, Guotai Wang, Kang Li, Qiang Yue

Faculty, Staff and Student Publications

Accurate preoperative MRI classification of gliomas is essential but challenging due to complex radiological features and inter-observer variability. This study evaluated three large language models (LLMs) for VASARI-based glioma classification compared to radiologist interpretations. We retrospectively analyzed 150 histopathologically confirmed gliomas (43 circumscribed astrocytic, 53 high-grade diffuse, 54 low-grade diffuse gliomas) using standardized MRI protocols. Three radiologists extracted VASARI features, while three LLMs (GPT-4, Claude3.5-Sonnet, Claude3.0-Opus) analyzed these features using standard input-output or knowledge-enhanced prompting incorporating diagnostic guidelines. Knowledge-enhanced prompting consistently outperformed standard prompting, improving diagnostic consistency (intra-model agreement: Sonnet κ = 0.91, Opus κ = 0.92, GPT-4 κ = …

Soluble Immune Factor Profiles In Blood And Csf Associated With Lrrk2 Mutations And Parkinson's Disease, Roshni Jaffery, Yuhang Zhao, Sarfraz Ahmed, Jackson G Schumacher, Jae Ahn, Leilei Shi, Yujia Wang, Yukun Tan, Jiayin Zhang, Ken Chen, Hussein Tawbi, Jian Wang, Michael A Schwarzschild, Weiyi Peng, Xiqun Chen

Faculty, Staff and Student Publications

Mutations in LRRK2, a leading genetic cause of Parkinson's disease (PD), are linked to immune dysregulation, but the immune profiles in the periphery and central nervous system (CNS) remain incompletely defined. This study utilized a large cohort of serum samples (n = 651) and matched CSF samples (n = 129) from LRRK2 mutation carriers and non-carriers, with and without PD, to assess immune regulators using Luminex immunoassay. After correction for multiple comparisons, LRRK2 mutations were associated with significantly elevated serum levels of SDF-1 alpha and TNF-RII, while CSF markers such as BAFF, CD40L, and IL-27 were nominally reduced. Regardless of …

Rewilding Gender: Toward Relational Understandings Of ‘The Wild’, Kim Ward

School of Geography, Earth and Environmental Sciences

This commentary reframes gender and rewilding through a relational understanding of wildness. Moving beyond a binary lens of ‘the wild’, it examines how gendered relations shape rewilding's material, emotional, and epistemic dimensions. Centring relational wildness exposes how rewilding challenges masculine imaginaries of control and ownership while opening space for more equitable multispecies relations.

‘The Truth Was, Most Biodiversity Was Redundant’: Caring About Mass Extinction In Ned Beauman’S Venomous Lumpsucker, David Sergeant

School of Law, Humanities and Social Sciences

This essay reads Ned Beauman’s Venomous Lumpsucker as exploring the gap that exists between caring about mass species extinction and taking meaningful action to prevent it. The novel, at first, undermines the conventional reasons for caring; however, one of its protagonists is then revealed as having become willing to die for the issue. Equally, the reason for this change proves strangely hard to locate. This essay argues that the real reason for caring about species extinction in Venomous Lumpsucker is connected to a transcendence of the self that aligns the novel with both science fiction and spiritual traditions; however, this …

Delphi Panel On Neuromodulation As A Treatment Strategy For Dry Eye Disease: Unlocking The Potential Of Natural Tear Production, Esen Akpek, Lyndon Jones, Kelly K Nichols, Lisa M Nijm, Stephen Pflugfelder

Faculty, Staff and Students Publications

Purpose: Chronic tear deficiency, through reduced production and/or increased evaporation, is regarded as a root cause of dry eye disease (DED). The goal of treating DED is restoration of the tear film ultimately resulting in ocular surface homeostasis. Multiple therapeutic prescription drugs to manage DED exist with varying speed of onset, overall magnitude of efficacy, and tolerability. Neuromodulation is an emerging treatment modality offering direct stimulation of natural tear production. A modified Delphi study was conducted to explore the role of neuromodulation as a treatment for DED.

Methods: Twenty DED experts participated in three rounds of structured electronic Delphi questionnaires. …

Developing Ehealth Interventions To Improve Diabetes Management In Emerging Adulthood: Qualitative Formative Study, Susan Eggly, Steven J Ondersma, Deborah A Ellis

Faculty, Staff and Student Publications

Background: Emerging adulthood is a high-risk period during which many with type 1 diabetes demonstrate suboptimal diabetes management and glycemic control. There is a need for effective, scalable interventions designed specifically for this population. Technology-based approaches are readily accessible to this age group. Furthermore, interventions consistent with self-determination theory-which posits that the fulfillment of psychological needs for autonomy, self-efficacy, and relatedness promotes intrinsic motivation for change-may resonate well with emerging adults' developmental needs for establishing independence and autonomy, and growing their social network.

Objective: This study aimed to enhance the potential relevance, sustainability, and efficacy of 3 self-determination theory-informed mobile …

Human Plasma Proteomic Profile Of Clonal Hematopoiesis, Linke Li, Shamsudheen K Vellarikkal, Md Mesbah Uddin, Abhishek Niroula, Gabriel Griffin, Michael C Honigberg, Amy E Lin, Christopher J Gibson, Daniel H Katz, Usman A Tahir, Shi Fang, Jacqueline S Dron, Michael Pan, Sara Haidermota, Shriienidhie Ganesh, Tajmara Antoine, Joshua Weinstock, Thomas R Austin, Gina M Peloso, Whitney Hornsby, Peter Ganz, Joann E Manson, Bernhard Haring, Charles Kooperberg, Alexander P Reiner, Joshua C Bis, Bruce M Psaty, Yuan-I Min, Adolfo Correa, Leslie A Lange, Wendy S Post, Jerome I Rotter, Stephen S Rich, James G Wilson, Benjamin L Ebert, Bing Yu, Christie M Ballantyne, Josef Coresh, Vijay G Sankaran, Alexander G Bick, Siddhartha Jaiswal, Robert E Gerszten, Nhlbi Trans-Omics For Precision Medicine, Peter Libby, Rajat M Gupta, Pradeep Natarajan

Faculty, Staff and Student Publications

Plasma proteomic profiles associated with subclinical somatic mutations in blood cells may offer insights into downstream clinical consequences. Here we explore these patterns in clonal hematopoiesis of indeterminate potential (CHIP), which is linked to several cancer and non-cancer outcomes, including coronary artery disease (CAD). Among 61,833 participants (3881 with CHIP) from TOPMed and UK Biobank (UKB) with blood-based DNA sequencing and proteomic measurements (1,148 proteins by SomaScan in TOPMed and 2917 proteins by Olink in UKB), we identify 32 and 345 proteins from TOPMed and UKB, respectively, associated with CHIP and most prevalent driver genes (DNMT3A, TET2, and ASXL1). These …

Addressing The Burden Of Prematurity And Its Prevention In Developing Countries: Is It Time To Act Now?, Mahaveer Singh Lakra, Amar Taksande, Revat J. Meshram, Ashwini Lakra, Amit Kumar, Deepak Gandhi, Roshan Prasad, Mayur Wanjari

Chulalongkorn Medical Journal

Around 3.5 million preterm births occur in India annually, accounting for about 25% of all preterm births worldwide. Prematurity poses a significant burden world-wide but leaves a special impact on the families and health systems of low-socioeconomic countries where easy and universal access to adequate health services is compromised. Premature birth imposes a significant risk of neonatal death among all under-fives due to organ immaturity, sepsis, and respiratory distress syndrome. Efforts to address prematurity on a global scale involve a multifaceted approach, including improving access to quality prenatal care, enhancing neonatal care services, and implementing public health interventions to reduce …

Self-Harm In Indonesian Adolescents And Undergraduates (2015–2025): A Bibliometric And Science-Mapping Study With Guidance And Counseling Implications, Febranti Putri Navion, Wikan Galuh Widyarto, Khilman Rofi' Azmi, Muhammad Sholihuddin Zuhdi, Febri Tri Cahyono, Muchammad Saiful Machfud, Alfan Arifuddin

Buletin Konseling Inovatif

The objective of this study is to map a decade (2015–2025) of Indonesian research on self-harm among secondary-school students and undergraduates while examining its implications for guidance and counseling practice in schools and universities. The methods applied were a bilingual, population-bounded bibliometric design in which data were retrieved from Google Scholar using Publish or Perish (PoP), screened through a PRISMA-guided protocol, and analyzed with performance indicators such as annual output, sources, top documents, and citation trends, complemented by science-mapping techniques including keyword harmonization and VOSviewer-based co-word networks. The results show that from 440 records initially retrieved, 119 studies met the …

Building Micro-Credential Frameworks: A Strategic Approach For Institutional Success, Justin R. Louder

TxDLA Journal of Digital Learning

The rise of micro-credentials in higher education presents a transformative opportunity for institutions to deliver flexible, workforce-aligned learning experiences. This article explores key strategies for implementing micro-credential frameworks that align with institutional goals while ensuring quality, scalability, and employer recognition. Drawing from existing models and institutional case studies, the article outlines five critical factors for success: (1) aligning micro-credentials with institutional priorities, (2) conducting market and audience analysis, (3) ensuring academic quality and rigor, (4) leveraging technological infrastructure, and (5) fostering external partnerships. The discussion highlights best practices from leading institutions and offers actionable recommendations for practitioners looking to launch …

The Moderating Effect Of Job Attitudes On Relationship Between Personality Traits And Employees Performance: An Applied Study On Ministry Of Education In Saudi Arabia, Waleed Rashed Alshery

UB Journal for Humanities

Current study aims to provide empirical evidence regarding the impact of personality traits (extraversion, neuroticism, conscientiousness, agreeable and openness to experience) on the employees' performance. Moreover, the paper is focused on investigating the moderating effect of job attitudes on the relationship between personality traits and employees' performance. The model of the study was developed based on relevant theoretical background. To examine the hypothesized model, the quantitative research design was employed. This study used the systematic sampling. 550 questionnaires were distributed among the employees working in the higher education system of KSA. 325 questionnaires were returned and were usable for analysis. …

Unleash The Potential - Our Vision For East Africa

Vision and mission statements

No abstract provided.

Aga Khan University Hospital, Kampala – Overview And Mission

Vision and mission statements

No abstract provided.

How Not To Go Viral? A Covid-19 Handbook For Students

University press releases and calendars

No abstract provided.

Front Matter, Editors Of Comparative Labor Law & Policy Journal

Comparative Labor Law & Policy Journal

Volume 45, Number 3

An Updated Perspective On Learning, Andrew S. Gibbons Iii

Faculty Publications

The subject of human learning is revisited. The emergence of new research findings in cognitive neuroscience and related disciplines using new imaging tools and techniques has revealed the existence of not one but two complementary learning systems. A newly-discovered prospection process, interacting with both memory systems, has been revealed as the pivotal mechanism of learning that leads to new experience and new memory records. The universal impact of emotion on this process also receives a new emphasis. This, coupled with the ever-present social environment, show learning to be the result of conversational activity. The existence of this more complete and …

Lost In Translation: Is Data Protection Labour Law Protection?, Michele Molè

Comparative Labor Law & Policy Journal

This article critically examines how the European General Data Protection Regulation (GDPR) defines and applies the legal categories of “data subject” and “data controller” within employment relationships. Under the GDPR, employers who collect and process personal data are classified as data controllers, while employees are designated as data subjects. However, this article argues that such a “translation” of data protection categories, rights, and obligations into the regulation of workplace dynamics requires closer examination. The focus is on evaluating whether the GDPR’s rights and obligations for data subjects and data controllers accurately capture the agency and interests of employee and employer …

Unpacking Alpha In Innovation-Driven Etfs: A Comparative Study Of Artificial Intelligence And Blockchain Funds, Davinder K. Malhotra

School of Business Faculty Papers

This paper evaluates the performance and portfolio role of Artificial Intelligence (AI) and Blockchain exchange-traded funds (ETFs) based on monthly returns from 2010 to 2025. The findings show that both AI and Blockchain ETFs generate positive alpha and high standalone returns but also display considerable drawdown risk. Their weak correlations with each other and with broad indices highlight diversification benefits, particularly when combined with U.S. benchmarks. Portfolio optimization reveals that Global Minimum Variance (GMV) and Tangency portfolios ascribe lower weights to these ETFs, while Risk Parity portfolios have a more balanced exposure, helping to diversify risks. Efficient frontier analysis highlights …

Interplay Of Menopause, Coronary Artery Calcium Score And Cardiovascular Disease Risk, Tanisha Mishra, Diksha Sanjana Pasnoor, Murtaza Gandhi, Nida Mohamed, Shaylika Chauhan, Kokou Adompreh-Fia, Kesha Mayank Doshi, Prerana Sevella, Rupak Desai

Abington Jefferson Health Papers

BACKGROUND: Postmenopausal women face an increased risk of cardiovascular disease (CVD) due to estrogen withdrawal, which exacerbates traditional cardiovascular risk factors such as dyslipidemia, glucose intolerance, and hypertension. Coronary Artery Calcium Score (CACS), a well-established marker of subclinical atherosclerosis, has emerged as a key predictor of adverse cardiovascular events. Despite the recognized association between menopause and heightened CVD risk, there remains a paucity of literature exploring the specific role of menopause in influencing CACS and its implications for cardiovascular morbidity and mortality.

AIM: To examine the interplay between menopause, CACS, and cardiovascular health by synthesizing existing literature.

METHODS: A comprehensive …

Dna Extrusion Size Determines Pathway Choice During Cag Repeat Expansion, Mayuri Bhatia, Ashutosh S. Phadte, Anna Lakhina, Anthony R. Monte Carloi Iii, Sarah Barndt, Anna Pluciennik

Department of Biochemistry and Molecular Biology Faculty Papers

DNA triplet repeat expansion causes several primarly neurological disorders like Huntington's disease, myotonic dystrophy type 1, and fragile-X related disorders. There is general consensus that recognition of extrahelical extrusions or hairpin-loop structures (formed by strand slippage) by the DNA mismatch repair protein MutSβ leads to repeat expansion by a mutagenic process. By contrast, the FAN1 nuclease attenuates triplet repeat expansion, the molecular basis of which was explained by our recent finding that FAN1 nuclease cleaves and initiates removal of extrahelical extrusions. Here we show that extrusions containing two or more triplet repeats are subject to recognition and processing by either …

Melanoma Mortality Disparity In Asian American And Pacific Islander (Aapi) Communities In Massachusetts: A Systematic Review And Integrated Policy Analysis, Norman Li

Capstones

Abstract

Objective: This systematic review and integrated policy analysis examines the disproportionately high melanoma mortality rate in Asian American and Pacific Islander (AAPI) populations with a focus on policy analysis, change, and equity in the Commonwealth of Massachusetts. The specific aim is to identify the systemic factors contributing to the late-stage diagnosis of Acral Lentiginous Melanoma (ALM) and to propose feasible, evidence-based policy and practice solutions.

Methods: A systematic literature review was conducted following PRISMA guidelines, utilizing databases including PubMed and CINAHL. The search strategy focused on keywords such as "melanoma mortality," "Asian American and Pacific Islander (AAPI)," "skin of …

Experiences Of African Immigrant Nurses Transitioning To The American Healthcare System, Chinomso Nwozichi

Biennial Convention (CONV)

Introduction: The global nursing shortage has driven a significant migration of African Immigrant nurses (AINs) to the United States. While AINs are essential to the U.S. healthcare workforce, they face considerable challenges, including cultural, professional, and emotional adjustments during their transition.

Methods: This study used a phenomenological approach guided by Ricoeur’s interpretive phenomenology framework to explore the lived experiences of AINs transitioning into the American healthcare system. The study was approved by the Institutional Review Board (IRB) of the primary investigator’s institution. Nineteen AINs working in various U.S. health institutions were selected through purposive sampling and participated in in-depth, unstructured …

Innovative Nursing Education: Bridging Theory And Practice With Simulation-Based Learning, Malliga Jambulingam, Raquel Bicknell

Biennial Convention (CONV)

Background: Nursing programs face significant challenges in securing clinical placements for students (American Association of Colleges of Nursing, 2022). Innovative technologies are transforming nursing education by providing realistic, immersive, and flexible learning experiences, bridging the gap between theory and clinical practice. Embracing the latest trends in simulation is crucial for creating an impactful educational environment and encouraging interdisciplinary collaboration (Cheng, 2024).

Objective: This review aims to evaluate recent innovations in simulation-based learning (SBL) in nursing education and their impact on nursing students' knowledge, skills, and confidence. It seeks to identify how innovative technologies are being utilized to overcome clinical placement …