Extracellular Matrix-Mycaf Signatures Correlate With Resistance To Neoadjuvant Apd-L1 Immune Checkpoint Inhibition With Durvalumab + Metformin In Hpv+ Hnscc, Pablo Llerena, Hani Samarah, Kathryn Nunes, Zhao Lin, Kelly Bridgham, Sruti Tekumalla, Amiti Jain, Larry A. Harshyne, Sanket Kumar Shukla, Ioannis Vathiotis, Madalina Tuluc, Stacey Gargano, John R. Eisenbrey, Scott W Keith, David Cognetti, Voichita Bar-Ad, Adam J. Luginbuhl, Rita S. Axelrod, Rajanikanth Vadigepalli, Hushan Yang, Diana Whitaker-Menezes, Megan Roche, My G. Mahoney, Athanassios Argiris, Charalambos C. Solomides, Jennifer Johnson, Md, Mouadh Barbirou, Amanda Miller, Andrew P. South, Ramkrishna Mitra, Alban J Linnenbach, Ubaldo E. Martinez-Outshoorn, Joseph Curry

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

PURPOSE: Immune checkpoint inhibitors (ICI) have demonstrated clinical benefit in head and neck squamous cell carcinoma (HNSCC); however, single-agent efficacy is limited, leaving significant unmet needs. Metformin may synergize with ICIs, offering promise to improve response rates. We leveraged multiomic data from a randomized, presurgical neoadjuvant trial (NCT03618654) evaluating a single infusion of the anti-PD-L1 ICI durvalumab with or without daily, standard dose metformin in previously untreated, nondiabetic patients with HNSCC to understand predictors of response and the effect of combination therapy.

PATIENTS AND METHODS: Clinical, pathologic, and correlative data were analyzed to investigate response and resistance mechanisms. We present …

Trust And Learning In Early Childhood, Anjuii Barrett

Arts & Sciences Graduate Student Theses and Dissertations

Abstract

Psychiatric Symptom Severity And Performance Monitoring: Intraindividual Variability In Neural Responses And Behavioral Adjustments To Errors, Bohyun Park

USF Tampa Graduate Theses and Dissertations

Performance monitoring is a cognitive process that involves evaluating one’s own performance and adjusting behavior accordingly. Atypical neural and behavioral indices of performance monitoring are commonly observed in individuals with psychopathology and have led to hypotheses that perturbed performance monitoring may contribute to functional impairment. However, neural and behavioral indices of performance monitoring are often examined in isolation, so it remains unclear how error-related neural activity relates to subsequent behavioral adaptation on a trial-by-trial basis, and whether this coupling varies across different levels of internalizing and externalizing symptoms. The present study examined trial-level relationships between error monitoring event-related brain potentials …

Enhancing Exercise Engagement And Gait In Parkinson Disease: Participation Factors, Novel Approaches, And The Role Of Rhythmic Auditory Cueing, Allison Haussler

WUSM Theses and Dissertations – All Programs

Parkinson disease (PD) is the second most common neurodegenerative disease, characterized by gait and balance impairments that reduce independence and diminish quality of life. Exercise and other rehabilitation strategies, such as rhythmic auditory cueing, are well-researched methods to address motor impairments. However, despite the strong body of research supporting these approaches, many individuals with PD remain sedentary and do not meet current exercise recommendations. This highlights a critical gap between evidence and real-world behavior.

While prior research identified general motivators and barriers to exercise in people with PD, emerging exercise modalities and the growing diversity of community-based programs emphasize the …

Replacement And Reputation, Navin Kartik, Elliot Lipnowski, Harry Pei

Cowles Foundation Discussion Papers

Does electoral replacement ensure that officeholders eventually act in voters’ interests? We study a reputational model of accountability. Voters observe incumbents’ performance and decide whether to replace them. Politicians may be “good” types who always exert effort or opportunists who may shirk. We find that good long-run outcomes are always attainable, though the mechanism and its robustness depend on economic conditions. In environments conducive to incentive provision, some equilibria feature sustained effort, yet others exhibit some long-run shirking. In the complementary case, opportunists are never fully disciplined, but selection dominates: every equilibrium eventually settles on a good politician, yielding permanent …

Advancing Cybersecurity Practice: Explainable Machine Learning For Network Intrusion Detection, Adam Grabowski, Shengjie Xu

Journal of Cybersecurity Education, Research and Practice

This research investigates explainable artificial intelligence (XAI) integration within machine learning (ML)-based intrusion detection systems (IDS), focusing on distinguishing malicious from benign network activities. We employed Random Forest and XGBoost models evaluated on widely recognized datasets, including NSL-KDD and UNSW-NB15, using both binary and multi-class classification tasks. The objective was to enhance cybersecurity operations through improved model transparency and interpretability. By integrating SHAP (SHapley Additive exPlanations) and LIME (Local Interpretable Model-Agnostic Explanations), the study offers comprehensive global and local insights into model decision-making processes. Results demonstrate SHAP's effectiveness in providing a broad, dataset-wide understanding of feature interactions and importance, while …

Brief Of Agudath Israel Of America, The Jewish Coalition For Religious Liberty, The National Council Of Young Israel, And The Jewish Community Council Of Sullivan County As Amici Curiae In Support Of Appellants, John A. Meiser, Meredith Holland Kessler

Court Briefs

No. 25-2191
Lost Lake Holdings, LLC v. Town of Forestburgh

On Appeal from the United States District Court for the Southern District of New York, No. 22-cv-10656-VB (Hon. Vincent L. Briccetti)

From the Summary of the Argument

As the district court seemed to recognize early on, JA-1506, the Town of Forestburgh is not going to allow Appellants to build a residential community for Hasidic Jews. Once the developers purchased a shovel-ready property for that purpose, the Town—in the words of one prominent resident and former member of the Comprehensive Plan Review Committee—“circle[d] the wagons.” JA-1570. That former committee member (along …

Consumer Lessons From A Pandemic, Nicole J. Olynk Widmar, Michael L. Smith, Erin Robinson

Purdue University Press Books

What did we learn about consumer behavior when the world was turned upside down due to COVID-19? Consumer Lessons From a Pandemic examines how a global crisis exposed and reshaped the values, priorities, and decision-making patterns of everyday people. From disrupted routines to supply-chain shocks, this volume explores the consumer behaviors that emerged in response to extreme uncertainty and how those behaviors continue to evolve. Topics include pandemic-induced grocery spending shifts, the importance of consumer trust, lessons from the infant-formula shortage, and the rise of remote work both as a preference and a negotiation point.

Laozi’S "Daodejing": A New Translation With Environmentalist Commentary, Steve Hallett

Purdue University Press Books

Laozi’s “Daodejing”: A New Translation With Environmentalist Commentary offers a new translation and fresh interpretation of the eighty-one-verse Daodejing, one of the central texts of Eastern philosophy. Likely written during the late Zhou Dynasty between 600–400 BCE, this foundational work is generally attributed to an individual named Laozi, although it is unlikely that any such person actually existed. Here, author Steve Hallett employs contemporary poetic form when translating the document’s approximately 5,000 Chinese characters and provides short analytical essays that illuminate the verses with a specific focus on the teachings they offer about social and environmental sustainability. His examination of …

Loss Of Mfap5 And Its Effect On Skin Homeostasis And Wound Healing, Chen Han, Heidi Yuan, Timothy J Koh, Lin Chen, Robert P Mecham, Luisa A Dipietro

2020-Current year OA Pubs

MFAP5, also known as microfibrillar-associated glycoprotein-2 (MAGP2), may influence parameters of skin wound healing related to scar formation. To further elucidate its role in skin wound healing, we assessed skin wound repair in Mfap5

The Evolution Of Southern Ocean Net Primary Production In A Changing Climate: Challenges And Opportunities, Alessandro Tagliabue, Thomas Ryan-Keogh, Alex Baker, Thomas S. Bibby, Chris Follett, Maeve C. Lohan, Alberto Naveira-Garabato, Daniel J. Mayor, Angela Milne, C. Mark Moore, Simon Ussher

School of Geography, Earth and Environmental Sciences

Net primary production in the Southern Ocean plays a critical role in governing ecosystem production, the biological carbon pump, and global biogeochemical cycles. Recent work has advanced our understanding of novel factors regulating Southern Ocean net primary production and the regional physiological adaptations employed by Southern Ocean phytoplankton in terms of their photosynthetic strategies and resource acquisition. Here we assess trends in Southern Ocean net primary production from different remote sensing algorithms and bgc-Argo floats to compare them to the latest Earth System Models used to forecast future changes under three different future climate scenarios. Overall, remote sensing and bgc-Argo …

Tumor Mirna Signatures Associate With Outcomes Of Patients With Stage Ii/Iii Melanoma, Jennifer M Wiggins, Qiao Zhang, Yian Zhang, Fatemeh Vand-Rajabpour, Douglas Hanniford, Linchen He, Yuting Lu, Jessica M Kenney, Keimya D Sadeghi, Diana Argibay, Irene Orlow, Klaus J Busam, Cecilia Lezcano, Tim K Lee, Li Luo, Ivan P Gorlov, Christopher Amos, Marc S Ernstoff, Venkatraman E Seshan, Anne E Cust, James Wilmott, Richard A Scolyer, Graham J Mann, Allison Reiner, Caroline E Kostrzewa, Eduardo Nagore, Pauline Funchain, Jennifer Ko, Sharon N Edmiston, Kathleen Conway, Paul B Googe, David W Ollila, Jeffrey E Lee, Judy R Rees, Cheryl L Thompson, Meg Gerstenblith, Marcus Bosenberg, Bonnie E Gould Rothberg, Iman Osman, Yvonne Saenger, Adam Z Reynolds, Tawny Boyce, Sheri Holmen, Shaofeng Yan, Elise Brunsgaard, Paul Bogner, Pei Fen Kuan, Nancy E Thomas, Colin B Begg, Ronglai Shen, Marianne Berwick, Yongzhao Shao, David Polsky, Eva Hernando

Faculty, Staff and Students Publications

Purpose: Patients with stage II and resected stage III melanomas have variable clinical outcomes, providing evidence of underlying biological differences in tumors and/or the patients themselves, beyond stage. The approval of adjuvant immunotherapy for stage IIB/C and resected stage III/IV disease (and adjuvant targeted therapy for resected stage III disease) has created a pressing need to develop biomarkers to accurately distinguish patients at low risk versus high risk for recurrence and death from melanoma. miRNAs are promising biomarkers because of their stability in tissues and fluids and their demonstrated functional and prognostic roles in melanoma. We hypothesized that miRNA expression …

Spinach (Spinacia Oleracea L) Flavonoids Are Hydrolyzed During Digestion And Their Bioaccessibility Is Under Stronger Genetic Control Than Raw Material Content, Michael P Dzakovich, Alvin L Tak, Elaine A Le, Rachel P Dang, Benjamin W Redan, Geoffrey A Dubrow

Children’s Nutrition Research Center Staff Publications

Spinach (

The Tax Adviser, Volume 3, Number 12, December 1972, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.

Tax Clinic, Thomas S. Oehring

Tax Adviser

No abstract provided.

Professions At Work: A Report On Complexity And The Income Tax (Part Ii), New York State Bar Association. Tax Section. Committee On Tax Policy

Tax Adviser

No abstract provided.

Reits: Problems And Possible Solutions, Burton M. Mirsky, Barry S. Auerbach

Tax Adviser

No abstract provided.

Pressures For Tax Conformity, Robert G. Skinner

Tax Adviser

No abstract provided.

The Tax Adviser, Volume 3, Number 11, November 1972, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.

Index: Subject Index—12 Months Ended October 1972; Author Index—12 Months Ended October 1972, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.

Tax Trends, Harry Z. Garian

Tax Adviser

No abstract provided.

Professions At Work: A Report On Complexity And The Income Tax (Part I), New York State Bar Association. Tax Section. Committee On Tax Policy

Tax Adviser

No abstract provided.

Hidden Assets And Latent Liabilities: The Non-Employee Spouse’S Community Interest In Qualified Deferred Compensation Plans, John R. Cohan, Albert J. Fink

Tax Adviser

No abstract provided.

Byrum Case And Closely Held Stock: An Analysis, Richard Covey

Tax Adviser

No abstract provided.

The Tax Adviser, Volume 3, Number 10, October 1972, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.

Tax Trends, Harry Z. Garian

Tax Adviser

No abstract provided.

Professions At Work: Proposed Regulations: Comments, Joel Forster

Tax Adviser

No abstract provided.

Tax Clinic, Walter C. Frank

Tax Adviser

No abstract provided.

Taxing The Quick And The Dead - Conflict Of Death Duties And Investment Incentives, H. W. T. Pepper

Tax Adviser

No abstract provided.

Final Accumulation Trust Regulations: Explained, Evaluated And Exemplified, Bernard Barnett

Tax Adviser

No abstract provided.