Digital Commons Network^™

251024_Skl_Lingbing_S032_En_M_V01, Julie A. Hochgesang, Krystin Balzarini, Alexander Ivanov, Kolby Lipiz, Steve J. Saenz, Grace Shi

LING BING

Scott Liddell's English narrative response to the list of sample questions related to the LING BING project.

Azo-Schiff Type Ligands Derived From Curcumin And Their Complexes With Transition Metals, Synthesis, Characterization And Bioactivity Studies, Fatima Rasheed Ali, H. A. Hassan

Baghdad Science Journal

In this work the precursor (W1) 2,2'-((1E,1'E)-(4,4'-diamino-5,5'-dimethyl-[1,1'-biphenyl]Diazene-2,1-diyl-3,3’-diyl)-bis((E)-pyridin-3-yldiazenyl)-[1,1'-biphenyl] or (W2) 3,3'-dimethyl-5,5'-bis((E)-pyridin-3-yldiazenyl)-[1,1'-biphenyl] -4,4'-diamine respectively were obtained from the reaction of 2-aminophenol or 2-aminopyridine with toluidine, respectively. Subsequently, these precursors were used for the synthesis of two ligands using the azo compounds (W1) or (W2) and curcumin to produce [H₄L¹] 4,4',4^'', 4^'''-((1E,1'E,6E,6'E)-((3,3'-bis((E)-(2-hydroxyphenyl)diazenyl)-5,5'-dimethyl-[1,1'-bi phenyl]-4,4'-diyl)bis(azaneylylidene))bis(5-hydroxyhepta-1,6-diene-1,7-diyl-3-ylidene))bis(azaneylylidene))bis(aza -neylylidene))tetrakis(2-methoxyphenol) or [H₂L²] 4,4',4^'',4^'''-((3,3'-dimethyl-,4,4'-diyl)bis- (azaneylylidene))bis(5-hydroxyhepta-1,6-diene-1,7-diyl-3-ylidene))tetrakis(2-methoxyphenol). The prepared ligands were characterized by F.T-I.R, U.V, ¹H-NMR,¹³C-NMR spectroscopy. This work also included the preparation of complexes through the reaction of ligands with the metal …

Synthesis, Spectral Characterization, Cytotoxic Assay, And Antimicrobial Evaluation Studies Of Some Transition Metal Complexes Of Schiff Base Derived From Amoxicillin, Alya’A J. Ahmed, Amaal S. Sadiq, Enaam Fadil Mousa, Mahasin Alias

Baghdad Science Journal

Four metal complexes of Schiff base ligand were prepared. To characterize both the ligand and the metal complexes, various techniques were employed, including elemental analysis, FT-IR spectroscopy, UV-Vis spectroscopy, molar conductivity measurements, magnetic moment determination, melting point, mass spectroscopy, ¹H-NMR and ¹³C-NMR spectroscopy. The results showed that the metal complexes formed have the formula [M(L)₂Cl₂]Cl_(n).H₂O, where L= Schiff base ligand and M=Cr(III), Rh(III), Pt(IV) and Au(III), n = 1, 2. Based on spectroscopic analysis, coordination with metal ions involves the ’N’ donor atom of N atoms of the imine and …

Common Heart Medication Shows Promise Against Liver Cancer, Clara Turnage

University of Mississippi News

OXFORD, Miss. – Liver cancer is the third-leading cause of cancer deaths worldwide, but a new study shows the solution to targeting this difficult-to-treat disease may already exist.

Shinydegsem: An Interactive Application For Pathway Perturbation Analysis In Gene Expression Studies Via Structural Equation Modeling, Zhehan Jiang, Jihong Zhang, Yuanfang Liu, Jinying Ouyang, Linlin Sun, Hao Guo

Counseling, Leadership, and Research Methods Faculty Publications and Presentations

Background Researchers in biology and bioinformatics are increasingly interested in unraveling the complex mechanisms underlying phenotypic variations. A key challenge lies in identifying perturbed biological pathways and understanding how these perturbations propagate through intricate gene regulatory networks. Results To address this challenge, we developed ShinyDegSEM, an interactive R Shiny application that leverages structural equation modeling (SEM) to facilitate pathway perturbation analysis in gene expression studies. ShinyDegSEM streamlines identifying differentially expressed genes (DEGs), generating pathway models based on biological knowledge, and evaluating these models to uncover perturbed pathway modules. This article is a tutorial to guide users through the analysis workflow, …

Acceleration Metrics Predict Propulsive Power At Within-Dive Temporal Scales In California Sea Lions, Mason R. Cole, Elizabeth A. Mchuron, Dan P. Costa, Paul J. Ponganis, Birgitte I. Mcdonald

Faculty Research, Scholarly, and Creative Activity

Background: Locomotion can drive variation in an animal’s energy expenditure, but the energetic cost of movement is difficult to measure at fine time scales in free-living animals. The 3 axis acceleration metrics Dynamic Body Acceleration (DBA) and Minimum Specific Acceleration (MSA) are commonly used in biologging studies as a proxy for activity or energy expenditure. These metrics hold potential for relatively simple and affordable estimates of movement-based energy expenditure, but have not been validated for use at fine temporal scales (e.g., within dives) due to logistical limitations of metabolic measurement techniques. Here, we use rates of propulsive power (W kg …

Correction: Magnetized Chitosan Hydrogel And Silk Fibroin, Reinforced With Pva: A Novel Nanobiocomposite For Biomedical And Hyperthermia Applications, Reza Eivazzadeh-Keihan, Zeinab Pajoum, Hooman Aghamirza Moghim Aliabadi, Adibeh Mohammadi, Amir Kashtiaray, Milad Salimi Bani, Banafshe Pishva, Ali Maleki, Majid M. Heravi, Mohammad Mahdavi, Elaheh Ziaei Ziabari

Rothman Institute Papers

The authors regret that they omitted a citation to ref. 1 in their original article. This citation should be included in Section 3 (Result and discussion) before Section 3.1 (FT-IR spectroscopy and XRD analysis). The authors wish to add the following paragraphs to the discussion section of the original article, to be read in Section 3 (Result and discussion) before Section 3.1 (FT-IR spectroscopy and XRD analysis), after the sentence “.Finally, hyperthermia application was appraised and all results were evaluated.” in order to clarify the novelty of this work over ref. 1. In the previous work, we developed a multifunctional …

Generation And Detection Of Photo-Thermal And Photo-Acoustic Waves In Solids For Advanced Near-Field Ir Imaging, Yide Zhang

Theses

Atomic force microscopy-infrared (AFM-IR) spectroscopy has become an essential tool for nanoscale chemical imaging, offering spatial resolution beyond the diffraction limit of conventional infrared spectroscopy. A typical AFM-IR setup directs a pulsed IR laser onto the sample, precisely at the tip of an AFM cantilever, detecting local absorption indirectly as photothermal expansion via the tip. This combination of AFM’s high spatial resolution and infrared spectroscopy’s chemical specificity enables detailed studies of a wide range of materials, from polymers and biological tissues to nanomaterials. However, the factors influencing AFM-IR signal generation and spatial resolution-especially in complex and inhomogeneous samples-remain challenging to …

Automating Candidate Gene Prioritization With Large Language Models: From Naive Scoring To Literature-Grounded Validation., Taushif Khan, Mohammed Toufiq, Marina Yurieva, Nitaya Indrawattana, Akanitt Jittmittraphap, Nathamon Kosoltanapiwat, Pornpan Pumirat, Passanesh Sukphopetch, Muthita Vanaporn, Karolina Palucka, Basirudeen Syed Ahamed Kabeer, Darawan Rinchai, Damien Chaussabel

Faculty Research 2025

MOTIVATION: Identifying promising therapeutic targets from thousands of genes in transcriptomic studies remains a major bottleneck in biomedical research. While large language models (LLMs) show potential for gene prioritization, they suffer from hallucination and lack systematic validation against expert knowledge.

RESULTS: The framework identified 609 sepsis-relevant genes with >94% filtering efficiency, demonstrating strong enrichment for inflammatory pathways including TNF-α signaling, complement activation, and interferon responses. Literature validation yielded 30 ultra-high confidence therapeutic candidates, including both established sepsis genes (IL10, TREM1, S100A9, NLRP3) and novel targets warranting investigation. Benchmark validation against expert-curated databases achieved 71.2% recall, with systematic correlation between computational …

Structure-Activity Relationships Of A–And B-Type Proanthocyanidins In Long-Term Dentin Biomodification And Biocompatibility, Yvette Alania, Mariana Reis-Havlat, Shu-Xi Jing, Fahimeh Tabatabaei, James B. Mcalpine, Shao-Nong Chen, Guido F. Pauli, Ana K. Bedran-Russo

School of Dentistry Faculty Research and Publications

Objective

To explore the structure-activity relationships of plant-based proanthocyanidins (PACs) with dental pulp stem cells (DPSCs) and the long-term biomechanical stability of PAC-modified dentin extracellular matrix (ECM).

Methods

Mid-coronal dentin ECM (n= 8) was treated with eight PAC tetramers and trimers with varying A-/B-type linkages. Chemo-mechanical analyses included dynamic mechanical analysis and ATR-FTIR spectroscopy. Viscoelastic components were calculated after PAC biomodification, 18-month incubation, and protein destabilization. Collagen structure was assessed via IR amide absorbance ratios. DPSCs were cultured with PACs at different concentrations (100, 10, and 1 μg/mL) to measure proliferation. ANOVA and post-hoc tests were used for …

2025 October, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for October of 2025.

Experimental Insights Into High Background Radiation: Reduced Cancer Risks In A Murine Model Study, S. M.J. Mortazavi, M. Arshadi, B. F. Baha'addini Baigy Zarandi, J. S. Welsh, H. Mozdarani, M. Haghani, N. Jooyan, S. Nematollahi, Negar Azarpira, Lembit Sihver

Informatics and Engineering Systems Faculty Publications

Background: Natural background radiation varies geographically and has potential implications for cancer development. High-level natural radiation areas (HLNRAs), like Ramsar, Iran, offer unique opportunities to study the biological effects of radiation exposure. This study investigates the relationship between high background radiation and tumor progression in a murine model. Materials and Methods: Thirty-two C57BL/6 mice were exposed to varying levels of natural radiation (0.097 μSv/h to 9.24 μSv/h) for two months, simulating conditions in Ramsar. Mice were divided into four groups based on radiation intensity. After exposure, 1106 B16-F10 melanoma cells were injected subcutaneously, and tumor growth was monitored for 24 …

Additively Manufactured Bioinspired Microstructures For Active Surface Modification, Zefu Ren

Doctoral Dissertations and Master's Theses

Advancements in additive manufacturing have facilitated the development of bioinspired microstructures, which hold promise for applications, such as liquid transport, self-cleaning, and anti-icing. However, the controllability of these microstructures remains an area requiring further exploration. This research explores the design, fabrication, and active control of 3D-printed bioinspired microstructures for dynamic wettability modulation. First, the anisotropic scales of butterfly wings were replicated through optimized two-photon polymerization printing strategies, achieving directional droplet motion controlled by structural geometry and arrangement. The reversed wetting trend compared with natural wings revealed key insights into the structure–performance relationship. Next, microstructures were integrated with dielectric elastomer actuators …

Cytotoxic And Genotoxic Effects Of Minor Temperature Changes And Zinc Oxide Nanoparticles Synthesized Using Plantago Major On Oncorhynchus Mykiss Gonadal Cells, Semra Çi̇çek, Sevda Işik

Turkish Journal of Zoology

Temperature changes and nanoparticle exposure have emerged as critical environmental stressors with potential cytotoxic and genotoxic effects on aquatic species. This study investigates the impact of zinc oxide nanoparticles (ZnO NPs), synthesized using Plantago major leaves, on Oncorhynchus mykiss gonadal (RTG-2) cells under different temperature conditions (23 °C, 24 °C, and 25 °C). RTG-2 cells were exposed to hexagonal ZnO NPs (≤100 nm) at concentrations of 6.25, 12.5, 25, 50, 75, and 100 μg/mL for 24 and 48 h. Cytotoxicity was assessed using the sulforhodamine B assay, and genotoxicity was evaluated via the comet assay. Results demonstrated that both temperature …

Species Delineation, Phylogeography And Conservation Of Temperate Perches (Actinopterygii: Percichthyidae) From An Endemism And Climate Change Hotspot, Michael P. Hammer, David L. Morgan, Stephen J. Beatty, Mark G. Allen, Peter J. Unmack, Sean J. Buckley, Luciano B. Beheregaray, Jon Murphy, Mark Adams

Research outputs 2022 to 2026

Context: The south-western corner of Australia is a biodiversity hotspot that includes a freshwater fauna with a high proportion of endemic species. The temperate perches comprise nearly half of the obligate freshwater fishes of the region, representing important components of local ecosystems and are of significant conservation concern. Aims: Provide a spatially comprehensive molecular genetic assessment of species boundaries and major substructure for all local members of the family to better understand the interplay of ecology and environment across a common landscape. Methods: Nuclear markers (allozymes) and matrilineal (cytb) datasets were generated to infer genetic groupings and any instances of …

Comparison Of Two Three-Dimensional Imaging Approaches Used In Fluorescence Microscopy, David Adaway, Chrysanthe Preza

QuaesitUM

No abstract provided.

Synthesis, Characterization, And Theoretical Investigation Of The Effectiveness As Anti-Corrosion For Chalcone Derivatives, Acer Juma Hamad, Hamdia Hateem Jawad, Kadhim A. Adem

Baghdad Science Journal

In this research, the focus was on preparing a number of chalcone derivatives using the Claisen-Schmidt reaction method through the reaction of some benzaldehyde derivatives with acetophenone substitutes in the presence of a basic medium represented by (NaOH) at a concentration of 10%. The benzaldehyde derivatives and acetophenone derivatives were also dissolved in ethanol at a concentration of 98%. Before starting the preparation, a number of chalcone derivatives were banned, which were prepared and referred to as [Ch1, Ch2,Ch3, Ch4, Ch5]. The substitutes that were used in the preparation were 4-chlorobenzaldehyde, 4-aminoacetophenone, benzaldehyde, 3-Nitroacetophenone, 4-Nitrobenzaldehyde. Acetophenone ,2-4-dichlorobenzaldehyde, and 4-(dimethylamino)benzaldehyde. The …

The Hepatic Glucagon Receptor As A Novel Regulator Of Lifespan, Alexander Tate Lasher

All ETDs from UAB

In developed nations the average lifespan has nearly doubled over the last 200 years, and the proportion of humans living into old age is ever increasing. While this is certainly a testament to the effectiveness of modern medicine and infrastructure, it presents a unique challenge to public health. Gains to health have not necessarily kept pace with the gains in lifespan, and the expanding aged population positions age-associated diseases to reach unprecedented prevalence. In light of this challenge, a mechanistic understanding of the aging process is necessary to identify factors that control longevity and to ultimately develop strategies for healthy …

The Physiological Impacts Of Nano-Ceramic Window Films In Hot-Climate Architecture: Theoretical Biological Study, Lina M. Shaker, Shahab Abdulla, Ralela Makline

AUIQ Complementary Biological System

This research explores the integration of nano-ceramic window films as a passive architectural strategy to improve both energy performance and occupant biological well-being in commercial buildings. The biological objective centers on enhancing health, comfort, and physiological stability by regulating thermal, optical, and radiative indoor conditions. Simulations on a three-story, 2,000 m² building demonstrated that high-performance films reduced indoor temperatures by up to 3.5°C, lowering thermal stress and core body heat load. Ultraviolet (UV) transmission was curtailed to as low as 1%, significantly decreasing skin damage doses below 0.2 MED/day. Select films maintained optimal Equivalent Melanopic Lux (EML) levels (up to …

Lived Experiences Of Transgender And Non-Conforming Individuals Related To Gender Separation Bathroom Policies, Patricia Ojea

Walden Dissertations and Doctoral Studies

The transgender and gender non-conforming population experiences discrimination when using public restrooms, but scholarly researchers do not know how the varying degrees of acceptance or rejection impact their daily lives. The purpose of this qualitative study was to better understand the lived experiences of transgender and non-conforming (TGNC) adults to determine if bathroom legislation helps alleviate adversity experienced by this group. Kingdon's multiple-streams framework and Meyer's minority stress theory were the theoretical frameworks that served as this study's foundation. The research questions for this study focused on how the lack of enabling restroom policies in New Jersey impacts TGNC adults …

Potential Role Of A Ruthenium-Based Compound Ru-Im In The Treatment Of Triple Negative Breast Cancer, Rachele Rameau

Dissertations, Theses, and Capstone Projects

Triple negative breast cancer (TNBC) is an aggressive and heterogeneous molecular subtype of breast cancer that has limited available treatments. The organometallic cationic ruthenium derivative Ru-IM was found to be highly water soluble, was differentially toxic for breast cancer cells and tumors, and was involved in the pI3K/AKT/mTOR pathway. However, a full understanding of genetic and epigenetic factors that can be part of regulatory mechanisms of Ru-IM is yet to be determined. Epigenetic assays including DNA methylation, histone acetylation and histone deacetylation were performed with the half inhibitory concentration (IC50) values of Ru-IM. Bisulfite sequencing of untreated and treated MDA-MB-231 …

Adaptive Filters At The First Olfactory Synapse, Elizabeth H Moss, Benjamin R Arenkiel

Duncan NRI Faculty and Staff Publications

The olfactory system is able to filter odor representations based on attention and learning. Two PLoS Biology studies reveal how short axon cells in the olfactory bulb integrate cholinergic input from the basal forebrain to dynamically regulate olfactory input.

Bodipy-Based Photocages For The Controlled Release Of Hydrogen Sulfide And Persulfides, Yanmei Li

Dissertations

Reactive sulfur species (RSS) such as hydrogen sulfide (H2S) and hydropersulfides (RSSH) are crucial mediators in a variety of physiological and pathological processes. Their regulatory roles span from maintaining cellular redox balance to influencing signaling pathways critical for homeostasis and stress responses. This dissertation investigates H2S and RSSH as biologically important molecules and explores the development of boron-dipyrromethene (BODIPY)-based photocages for its controlled, light-triggered release. Given H2S and RSSH's critical role in redox regulation and cellular protection, achieving spatiotemporal control over its delivery is essential for both therapeutic and research applications. BODIPY scaffolds offer favorable photophysical properties, including visible-light activation …

Perception Of Conventional Cigarettes And Vaping Among Smokers And Nonsmokers: A Cross-Sectional Study, Indrayadi Gunardi, Rahmi Amtha, Firstine Kelsi Hartanto, Niko Falatehan, Alyah Heriandi, Angelita Victoria Kurniawan, Najla Nadiah, Wiwiek Poedjiastoeti, Andrijanto Andrijanto, Elizabeth Fitriana Sari

Journal of Dentistry Indonesia

Objectives: The growing popularity of vaping has introduced additional challenges, as potential health risks are still under investigation. Exploring differences in smoking perceptions between smokers and non-smokers could provide valuable insights into smoking behavior and inform effective intervention strategies. This study aimed to evaluate and compare the perceptions of smoking, specifically vaping and conventional cigarette use, among young adult smokers and non-smokers. Methods: An analytical cross-sectional design was employed, with 542 university students included through random sampling, using a questionnaire consisting of 8 items. Data were analyzed using the Kruskal-Wallis test and Rasch model analysis. Results: Of the subjects, 259 …

Design And Development Of A Standalone Digital Holographic Microscope Employing Phase-Driven Reconstruction And Classification For Biomedical Imaging And Optical Diagnostics, Charlotte Kyeremah

Graduate Doctoral Dissertations

Access to advanced biomedical imaging technologies remains a significant challenge in resource-limited settings, especially for early disease detection and monitoring of diseases such as malaria, HIV, and other blood-borne diseases. Although point-of-care (POC) devices have gained popularity in global health, many rely on antibody-based tests, lateral flow strips, or optical readouts that often lack quantitative capabilities, sensitivity to early infections, or versatility in different diagnostic targets. In addition, these systems are typically dependent on disposable reagents or manual interpretation, which limits their effectiveness in remote areas. Digital Holographic Microscopy (DHM) presents a promising alternative as a label-free imaging method capable …

The Shorthorn: February 27, 1974

The Shorthorn Newspaper Collection: 1970s

No abstract provided.

Established And Emerging Asthma Biomarkers With A Focus On Biologic Trials: A Narrative Review, Philip F Lavere, Kaitlin M Phillips, Nicola A Hanania, Muhammad Adrish

Faculty, Staff and Students Publications

Chronic airway inflammation with variable airflow obstruction is clinical asthma, and it arises from distinct molecular and pathological mechanisms called endotypes. Biomarkers allow for precise endotype characterization and have been used in clinical trials to design, monitor, and evaluate outcomes for asthma biologic therapies. This review will highlight the central and evolving role of biomarkers for past, present, and future asthma, with a focus on regulatory-approved biologic therapies and emerging biomarkers. Established biomarkers, including serum immunoglobulin E (IgE), blood eosinophils, the fraction of exhaled nitric oxide (FeNO), and serum periostin, helped elucidate the complex pathophysiology of the eosinophilic type 2 …

Computational And Mathematical Modeling Of Microbial Community And Host Responses To Microbiota-Directed Complementary Foods Administered To Children With Acute Malnutrition., Steven J. Hartman

Arts & Sciences Graduate Student Theses and Dissertations

Globally, millions of children suffer from undernutrition, with stunting affecting 150 million and wasting nearly 50 million under five years old. Current interventions have shown limited effectiveness in mitigating long-term consequences such as stunted growth, cognitive deficits, and immune dysfunction. Through this body of work, I investigated the efficacy of a microbiota- directed complementary food (MDCF-2) as a next generation therapeutic food to combat childhood stunting. Across two randomized controlled trials involving Bangladeshi children with either moderate acute malnutrition or post-severe acute malnutrition, MDCF-2 significantly outperformed standard ready-to-use supplementary foods (RUSF), leading to significantly improved ponderal and sustained linear growth …

Population Structure And Stock Assessment Of Tilapia Species In Coastal Lagoon, Lake Manzala, Egypt, Mohamed Fetouh, Kariman Shalloof, Attia El-Aiatt, Alaa El-Far, Walid Aly

Blue Economy

This study aimed to estimate the biology and population structure of cichlid species in Lake Manzala, where tilapias are the main catch. Samples were collected from commercial fishing boats in the fishing areas between 2019 and 2021. The length frequency distributions were evaluated using FiSAT II software. The results showed that Oreochromis niloticus was the most dominant species, making up 50% of the tilapia catch. Four age groups were found in O. niloticus and Coptodon zillii, and three in Oreochomis aureus and Sarotherodon galilaeus. Age group II was the most dominant across all species. The von Bertalanffy equation constants (L∞ …

Artificial Transneurons Emulate Neuronal Activity In Different Areas Of Brain Cortex, Rivu Midya, Ambarish S Pawar, Debi P Pattnaik, Eric Mooshagian, Pavel Borisov, Thomas D Albright, Lawrence H Snyder, R Stanley Williams, J Joshua Yang, Alexander G Balanov, Sergei Gepshtein, Sergey E Savel'ev

2020-Current year OA Pubs

Rapid development of memristive elements emulating biological neurons creates new opportunities for brain-like computation at low energy consumption. A first step toward mimicking complex neural computations is the analysis of single neurons and their characteristics. Here we measure and model spiking activity in artificial neurons built using diffusive memristors. We compare activity of these artificial neurons with the spiking activity of biological neurons measured in sensory, pre-motor, and motor cortical areas of the monkey (male) brain. We find that artificial neurons can operate in diverse self-sustained and noise-induced spiking regimes that correspond to the activity of different types of cortical …