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Articles 3691 - 3720 of 23076
Full-Text Articles in Entire DC Network
Review Of Fourierist Networks Of Reform: The Social Networks Of Nineteenth Century Reformers, Mitchell K. Jones
Review Of Fourierist Networks Of Reform: The Social Networks Of Nineteenth Century Reformers, Mitchell K. Jones
Communal Societies
No abstract provided.
Review Of Foodtopia: Communities In Pursuit Of Peace, Love & Homegrown Food, Etta M. Madden
Review Of Foodtopia: Communities In Pursuit Of Peace, Love & Homegrown Food, Etta M. Madden
Communal Societies
No abstract provided.
The Ecstatic Communion And Revelatory Foibles Of Sun House: A Reflection, Chris Roth
The Ecstatic Communion And Revelatory Foibles Of Sun House: A Reflection, Chris Roth
Communal Societies
No abstract provided.
Hematologic Recovery In Ehrlichia-Infected Dogs: A Meta-Analysis Of Doxycycline’S Therapeutic Impact, Mahmoud Kandeel, Mohamed Marzok, Maryam Mahmoud, Khalid M. Al Khodair
Hematologic Recovery In Ehrlichia-Infected Dogs: A Meta-Analysis Of Doxycycline’S Therapeutic Impact, Mahmoud Kandeel, Mohamed Marzok, Maryam Mahmoud, Khalid M. Al Khodair
The Thai Journal of Veterinary Medicine
Canine monocytic ehrlichiosis (CME), caused by Ehrlichia canis, is a globally prevalent tick-borne disease with significant hematologic manifestations, including anemia and thrombocytopenia. Doxycycline is the first-line treatment, but its effects on hematologic recovery remain inconsistently reported. This meta-analysis evaluates the impact of doxycycline on hematologic parameters in E. canis-infected dogs. A systematic search was conducted across PubMed, Scopus, Web of Science, and EMBASE. Five studies (one randomized controlled trial, four non-randomized trials) involving 116 dogs were included. Data on erythrocytes, leukocytes (neutrophils, eosinophils, monocytes, and lymphocytes), platelets, hemoglobin, and hematocrit were extracted. Heterogeneity was assessed using I² statistics, …
Situating Media Literacy With A Theory Of Change: “Mapping Jmle”, Julian Mcdougall
Situating Media Literacy With A Theory Of Change: “Mapping Jmle”, Julian Mcdougall
Journal of Media Literacy Education Pre-Prints
This article uses a theory of change to identify the difference media literacy work makes to people’s lives, based on work published in the Journal of Media Literacy Education in 2024. This is a pilot study stage towards a global field mapping, aiming to make the case for media literacy as an essential element in the health of the communication ecosystem (forthcoming, 2025).
This is an exploratory pilot sharing provisional evidence, but this is the point of the the broader work this article is a part of which seeks to is describe how media literacy can make a difference to …
Techniques For Providing Asynchronous Reliable Transmission Protocol For Application-To-Application Communication, Ashish Kumar Khatri Mr., Preet Nepolean Dabre Mr.
Techniques For Providing Asynchronous Reliable Transmission Protocol For Application-To-Application Communication, Ashish Kumar Khatri Mr., Preet Nepolean Dabre Mr.
Defensive Publications Series
Techniques are disclosed for providing asynchronous reliable transmission (ART) protocol for Application-to-Application messages. A communication protocol is designed to support communication between two devices asynchronously over channels that have limitations to facilitate asynchronous communication and have limited bandwidth. The ART protocol solves communication challenges that arise when transmitting data over channels with such limitations. The ART protocol has the provision to expand for future use cases such as encryption. Further, the ART Protocol provides mechanisms for data packet fragmentation, allowing larger packets to be transmitted over channels with limited bandwidth.
When Is Free Speech “Beyond” The Constitution?, Abner S. Greene
When Is Free Speech “Beyond” The Constitution?, Abner S. Greene
The Journal of Contemporary Legal Issues
The constitution of a nation without a state action doctrine might limit private restriction or compulsion of speech just as it limits the state. In such a nation, “free speech beyond the constitution” might not be a particularly meaningful concept. In the United States, however, the First Amendment’s free speech clause limits only what the federal, state, and local governments may do. As a nonconstitutional policy matter, it might or might not be a good idea for the government to impose First Amendment- like restrictions on private actors or for private actors to voluntarily impose First Amendment-like restrictions on themselves. …
Comment On Hurd And Moore, Richard Arneson
Comment On Hurd And Moore, Richard Arneson
The Journal of Contemporary Legal Issues
In their essay on “Wrongful Student Speech and Rightful Private University Responses to It,” Professors Heidi Hurd and Michael Moore (hereafter, Hurd & Moore) deepen the discussion by situating it in a general account of moral limits on freedom of expression and by noting connections to some of their own views on moral theory. The result is an excellent primer on freedom of speech, and more than just a primer. Their general views are shown to have plausible implications for tangled questions about what private university administrators ought to do in response to problematic examples of campus protest. That this …
Phosphorylation Of Ryr1 At Ser2902 Decreases Ca2+ Leak In Skeletal Muscle And Susceptibility To Malignant Hyperthermia And Heat Stroke, Rachel Sue Zhen Yee, Chang Seok Lee, Ting Chang, Sung Yun Jung, Omar Yousif, Courtney Cavazos, John Colyer, Filip Van Petegem, George G Rodney, Susan L Hamilton
Phosphorylation Of Ryr1 At Ser2902 Decreases Ca2+ Leak In Skeletal Muscle And Susceptibility To Malignant Hyperthermia And Heat Stroke, Rachel Sue Zhen Yee, Chang Seok Lee, Ting Chang, Sung Yun Jung, Omar Yousif, Courtney Cavazos, John Colyer, Filip Van Petegem, George G Rodney, Susan L Hamilton
Faculty, Staff and Students Publications
The ryanodine receptor 1 (RYR1) is the sarcoplasmic reticulum (SR) Ca2+ release channel required for both skeletal muscle contraction and Ca2+ leak. Mutations in RYR1 cause malignant hyperthermia susceptibility (MHS) and enhanced sensitivity to heat stroke (ESHS), which can result in death due to excessive skeletal muscle thermogenesis upon exposure to volatile anesthetics or heat. Here, we investigated the molecular and physiological functions of phosphorylation of RYR1 at Ser2902 by the kinase SPEG (striated muscle preferentially expressed protein). Muscle from SPEG-deficient mice expressing RYR1 with a Ser2902 →Asp2902 (S2902D) point mutation to mimic phosphorylation by SPEG showed decreased SR Ca2+ …
The Latest In Resuscitation Research: Highlights From The 2024 American Heart Association's Resuscitation Science Symposium, Gabriela M Galli, Aarthi Kaviyarasu, Sachin Agarwal, Catherine R Counts, Tommaso Scquizzato, Betty Yang, Clark G Owyang, Ryan Coute, Simon Orlob, Lindsay Shepard, Saleem Halablab, James Horowitz, Sarah Perman, Ryan Morgan, Anne Grossestreuer, Jacob Vine, Nicholas Johnson, Luke Andrea, Ari Moskowitz, Benjamin Abella, Cameron Dezfulian, Walid H Farooqi, Felipe Teran
The Latest In Resuscitation Research: Highlights From The 2024 American Heart Association's Resuscitation Science Symposium, Gabriela M Galli, Aarthi Kaviyarasu, Sachin Agarwal, Catherine R Counts, Tommaso Scquizzato, Betty Yang, Clark G Owyang, Ryan Coute, Simon Orlob, Lindsay Shepard, Saleem Halablab, James Horowitz, Sarah Perman, Ryan Morgan, Anne Grossestreuer, Jacob Vine, Nicholas Johnson, Luke Andrea, Ari Moskowitz, Benjamin Abella, Cameron Dezfulian, Walid H Farooqi, Felipe Teran
Faculty, Staff and Students Publications
No abstract provided.
Molecular Imaging Of The Cochlea, Parveen Bazard, Mikalai Budzevich, Xiaoxia Zhu, Bo Ding, Robert Dana Frisina
Molecular Imaging Of The Cochlea, Parveen Bazard, Mikalai Budzevich, Xiaoxia Zhu, Bo Ding, Robert Dana Frisina
USF Patents
A novel method of measuring endocochlear potential and cochlear function in a patient is presented. The method uses nuclear imaging, such as PET or SPECT, with a radiotracer such as 201Tl to visualize any potassium ion loss in the cochlea of the patient which can contribute to auditory disorders such as hearing loss. This non-invasive technique represents a new method for auditory diagnoses by measurement of cochlear properties which can aid in the development of new therapeutics for auditory disorders.
Post-Traumatic Stress Disorder (Ptsd) In Zoulfa Katouh’S As Long As The Lemon Trees Grow, Mai Hazem El Gebali
Post-Traumatic Stress Disorder (Ptsd) In Zoulfa Katouh’S As Long As The Lemon Trees Grow, Mai Hazem El Gebali
English Language and Literature
This paper aims to analyze the representation of Post-traumatic Stress Disorder (PTSD) in Zoulfa Katouh’s novel, As Long as the Lemon Trees Grow (2022). Katouh, a Canadian-Syrian author who specializes in drug sciences, sets her debut novel against the backdrop of the war in Syria in the aftermath of the Arab Spring. The protagonist, Salama, a teenage girl pursuing an undergraduate degree in pharmacy, faces the harrowing realities of war and volunteers as a surgical assistant amidst the chaos of bombings and sniper attacks. As a result of the war, Salama tragically loses almost all her family members, and in …
Adoption Of Agrivoltaics In Developing Countries: A Review On Challenges, Opportunities And Future Prospects, Abdi J. Athumani, Pater Makolo
Adoption Of Agrivoltaics In Developing Countries: A Review On Challenges, Opportunities And Future Prospects, Abdi J. Athumani, Pater Makolo
Tanzania Journal of Engineering and Technology (TJET)
This paper provides a review of agrivoltaics technology and how it has been applicable in developing countries, including African countries. Agrivoltaics, the integration of agricultural production with photovoltaic energy generation, offers promising solutions to water- energy-food nexus in developing countries. This technology offers the dual benefit of increasing agricultural productivity while generating clean energy, which is very important for regions facing frequent electricity shortages and declining agricultural yields due to climate change. However, despite its potential, the adoption of agrivoltaics in developing nations remains limited in comparison to developed countries due to financial, technical and policy constraints. This paper explores …
October 2025 Faculty Senate Packet, University Of Nebraska At Kearney Faculty Senate
October 2025 Faculty Senate Packet, University Of Nebraska At Kearney Faculty Senate
Faculty Senate Packets
No abstract provided.
The Prospector, October 7, 2025, Utep Student Publications
The Prospector, October 7, 2025, Utep Student Publications
The Prospector
No abstract provided.
Picture Perfect Stem: Ngss Science Standards Alignment Guide, Dr. Peter J. Kalenda Assistant Professor, Elementary Science & Math, School Of Education
Picture Perfect Stem: Ngss Science Standards Alignment Guide, Dr. Peter J. Kalenda Assistant Professor, Elementary Science & Math, School Of Education
School of Education
The Picture-Perfect STEM: Next Generation Science Standards (NGSS) Alignment Chart functions as a comprehensive reference tool that aligns all Picture-Perfect STEM lessons with the NGSS. The resource is organized by grade level (K-5) and disciplinary areas (Physical Science, Life Science, Earth Science, and Engineering), enabling teachers to quickly locate appropriate lessons for their specific instructional needs.
Each grade level section provides specific lesson alignments with NGSS standards appropriate for elementary students. The chart includes both individual grade-specific lessons and cross-grade applications that can be adapted for different developmental levels.
For more details about how to use this document, its core …
A Preliminary, Photography-Based Assessment Of Bee Diversity At The Finca Botánica Organic Farm In The Central Pacific Coast Of Ecuador, Joseph S. Wilson, Tyler M. Wilson, Chris Packer, Orlando Pacheco
A Preliminary, Photography-Based Assessment Of Bee Diversity At The Finca Botánica Organic Farm In The Central Pacific Coast Of Ecuador, Joseph S. Wilson, Tyler M. Wilson, Chris Packer, Orlando Pacheco
Biology Faculty Publications
Understanding wild bee diversity is critical for pollinator conservation, particularly in understudied tropical regions like coastal Ecuador. This preliminary study provides a photography-based assessment of bee diversity at Finca Botánica, an organic and regenerative farm on Ecuador’s central Pacific coast. Over a 10-day survey in December 2024, researchers documented 51 bee species across four families, with Apidae being the most represented. The study highlights a predominance of solitary, ground-nesting bees and a lower-than-expected diversity of Meliponini (stingless bees) and Euglossini (orchid bees) compared to other regions of Ecuador. Many species were found in forest patches, ecological corridors, and cover-cropped maize …
Are Mice A Bad Model For Successive Negative Contrast?, Alan M. Daniel
Are Mice A Bad Model For Successive Negative Contrast?, Alan M. Daniel
All Faculty Scholarship (Archived)
Successive negative contrast (SNC) is a procedure in which animals trained with a large reward consume less of a subsequent smaller reward than animals always trained with the small reward. Studies of SNC in rats have emerged as an important tool in understanding the affective neuroscience of unexpected loss. Establishing a similar procedure in a murine model would allow access to a greater toolbox of neuroscience techniques (e.g., optogenetics, transgenics) that are more readily available in mice than rats. While the rat SNC literature has been thriving for decades, only a few studies report SNC effects in mice. This paper …
A Soft-Stiff Patterned Bioengineering Model Reveals Kinase Pathways Driving Directional Cell Migration In Pulmonary Arterial Hypertension, Tamanna Islam, Jacob Hooper, Xiaojun Zhang, Clarissa Garcia, Md Mahedi Hasan, David H Drewry, Mohammad Anwar Hossain, Taslim A Al-Hilal
A Soft-Stiff Patterned Bioengineering Model Reveals Kinase Pathways Driving Directional Cell Migration In Pulmonary Arterial Hypertension, Tamanna Islam, Jacob Hooper, Xiaojun Zhang, Clarissa Garcia, Md Mahedi Hasan, David H Drewry, Mohammad Anwar Hossain, Taslim A Al-Hilal
Faculty, Staff and Student Publications
Directional cell migration by pulmonary arterial cells (PACs) is one of the important features of diseases involving arterial remodeling, such as pulmonary arterial hypertension (PAH), a disease that is often characterized by reduced arterial compliance and increased extracellular matrix (ECM) stiffening. However, there are no therapeutics that can halt the directional cell migration of PACs in PAH. The inability to identify drug targets or drugs against the directional cell migration during PAH pathogenesis stems from an incomplete understanding of the process and a lack of effective translational models for screening of candidate small molecules. Here, for the first time, we …
Enhanced Piezo1 Function Contributes To The Pathogenesis Of Sickle Cell Disease, Luis O Romero, Manisha Bade, Laila Elsherif, Jada D Williams, Xiangmei Kong, Adebowale Adebiyi, Kenneth I Ataga, Shang Ma, Julio F Cordero-Morales, Valeria Vásquez
Enhanced Piezo1 Function Contributes To The Pathogenesis Of Sickle Cell Disease, Luis O Romero, Manisha Bade, Laila Elsherif, Jada D Williams, Xiangmei Kong, Adebowale Adebiyi, Kenneth I Ataga, Shang Ma, Julio F Cordero-Morales, Valeria Vásquez
Faculty, Staff and Student Publications
Sickle cell disease (SCD), an inherited blood disorder caused by a mutation in the β-globin gene, is characterized by sickle erythrocytes that are prone to hemolysis, leading to anemia and vaso-occlusion crises. In sickle erythrocytes, hemoglobin aggregation is followed by altered cation permeability and subsequent dehydration. Interventions that restore cation permeability can decrease hemolysis and ameliorate the symptoms associated with SCD. PIEZO1 is a nonselective mechanosensitive cation channel that regulates erythrocyte volume. Gain-of-function (GOF) mutations in PIEZO1 cause hemolytic anemia by increasing cation permeability, leading to erythrocyte dehydration in humans and mice. Although PIEZO1 plays a key role in erythrocyte …
Multicenter Stroke Preclinical Assessment Network Analysis Of Cardiovascular Risk Factor Subgroups Treated With The Poly(Adp-Ribose) Polymerase Inhibitor Veliparib, Raymond C Koehler, Karni Bedirian, Mu-Hsun Chen, Yanrong Shi, Suyi Cao, Brooklyn D Avery, Senthilkumar S Karuppagounder, Kazi Akhter, Adnan Bibic, Valina L Dawson, Ted M Dawson, Márcio A Diniz, Jessica Lamb, Karisma A Nagarkatti, Anjali Chauhan, Jaroslaw Aronowski, Louise D Mccullough, Andreia Lopes De Morais, Xuyan Jin, Cenk Ayata, Mariia Kumskova, Rakesh B Patel, Anil K Chauhan, Enrique C Leira, Pradip K Kamat, Mohammad B Khan, Krishnan M Dhandapani, David C Hess, Ligia S B Boisserand, Basavaraju G Sanganahalli, Lauren H Sansing, Patrick D Lyden
Multicenter Stroke Preclinical Assessment Network Analysis Of Cardiovascular Risk Factor Subgroups Treated With The Poly(Adp-Ribose) Polymerase Inhibitor Veliparib, Raymond C Koehler, Karni Bedirian, Mu-Hsun Chen, Yanrong Shi, Suyi Cao, Brooklyn D Avery, Senthilkumar S Karuppagounder, Kazi Akhter, Adnan Bibic, Valina L Dawson, Ted M Dawson, Márcio A Diniz, Jessica Lamb, Karisma A Nagarkatti, Anjali Chauhan, Jaroslaw Aronowski, Louise D Mccullough, Andreia Lopes De Morais, Xuyan Jin, Cenk Ayata, Mariia Kumskova, Rakesh B Patel, Anil K Chauhan, Enrique C Leira, Pradip K Kamat, Mohammad B Khan, Krishnan M Dhandapani, David C Hess, Ligia S B Boisserand, Basavaraju G Sanganahalli, Lauren H Sansing, Patrick D Lyden
Faculty, Staff and Student Publications
Background: The Stroke Preclinical Assessment Network tested 6 therapeutic interventions initiated at the time of reperfusion after focal ischemic stroke in young mice, aging mice, obese mice, and spontaneously hypertensive rats. This randomized, controlled trial was conducted across 6 sites with concealed treatment and blinded neurobehavior assessments. The trial had an adaptive design with preset levels of efficacy and futility interrogated after each of 4 stages. The primary outcome was turning preference on the corner test at 1 month. The PARP (poly(ADP-ribose) polymerase) inhibitor, veliparib, was considered futile after the second stage when pooling all animal models (n=231 …
From Fort To Prison: The Production Of Iloilo City, Ram Paulo A. Anayan
From Fort To Prison: The Production Of Iloilo City, Ram Paulo A. Anayan
Akda: The Asian Journal of Literature, Culture, Performance
The foundation of colonial cities in the Philippines rests on violence. The Spanish policies of the reducción forced the natives to settle in pueblos where colonial power is ensured. The resistance of some natives brought about the divide between tagabayan (town dweller) and tagabundok (mountain dweller)—respective connotations of civilization and savagery (Lumbera and Lumbera, 36). This paper examines how this centripetal-centrifugal force of simultaneous identity-production and displacement is echoed in the metonymy of the fort on which the origins of Iloilo City stand. I navigate how this movement manifests in the consciousness of the city across historical periods represented by …
Graffiti, Neoliberalismo, At Tunggalian Para Sa Espasyo Sa Lungsod Quezon (Graffiti, Neoliberalism, And Contestations For Space In Quezon City), Harvey James G. Castillo
Graffiti, Neoliberalismo, At Tunggalian Para Sa Espasyo Sa Lungsod Quezon (Graffiti, Neoliberalism, And Contestations For Space In Quezon City), Harvey James G. Castillo
Akda: The Asian Journal of Literature, Culture, Performance
Magmula nang umigting ang neoliberalismo bilang ekonomikong kaayusan noong dekada 1970, daan-daang bansa na ang maaapektuhan nito at libo-libong espasyo ang mahuhubog ng masidhing neoliberal na lohika. Tatawagin ng mga paham bilang neoliberal na urbanismo—ang ganitong diwa ng pagsasaayos sa mga lungsod, na nasa anyo ng pribatisasyon at hentripikasyon ng mga espasyo, ay magdudulot ng pag-unlad at lubos-at-labis na yaman para sa iilan, at kaaba-abang karalitaan at guho para sa nakararami. Sa ganitong konteksto ng neoliberal na urbanismo, isinusulong ng artikulo na ang mga graffiti ay umiiral bilang tekstong panlipunan na instrumental sa agawan ng espasyo sa pagitan ng …
Cemented Republic: Infrastructure And Slow Violence In Jun Cruz Reyes’S Ang Huling Dalagang Bukid At Ang Authobiography Na Mali: Isang Imbestigasyon, Jonah Leigh E. Ramos
Cemented Republic: Infrastructure And Slow Violence In Jun Cruz Reyes’S Ang Huling Dalagang Bukid At Ang Authobiography Na Mali: Isang Imbestigasyon, Jonah Leigh E. Ramos
Akda: The Asian Journal of Literature, Culture, Performance
To read the novel is to read history from a vantage point, and to read Jun Cruz Reyes’s metafiction novel, Ang Huling Dalagang Bukid at ang Authobiography na Mali: Isang Imbestigasyon (2011), is to read unaccounted-for experiences of violence in spaces that house the spectacle of national infrastructure. Informed by concepts from environmental humanities and urban studies, this paper explores the intersection of infrastructure and violence in Ang Huling Dalagang Bukid. It interrogates the choice experimental form of the novel, close reads descriptive passages about infrastructure, and highlights corresponding manifestations of slow violence impacting humans and nonhumans alike. The …
Reading-As-Lesbian And Desiring-As-Lesbian: The Commodification Of Kilig And Coming-Of-Age In Samantha Lee’S Billie And Emma (2018), Reya Mari S. Veloso
Reading-As-Lesbian And Desiring-As-Lesbian: The Commodification Of Kilig And Coming-Of-Age In Samantha Lee’S Billie And Emma (2018), Reya Mari S. Veloso
Akda: The Asian Journal of Literature, Culture, Performance
In 2018, Samantha Lee’s second movie Billie and Emma was screened in the QC International Film Festival. I watched it during the pandemic and had since been arrested by its portrayal and narrative of lesbian and queer teens. In this paper, I argue that Samantha Lee’s Billie and Emma (2018) offers a subversive narrative of lesbians by using kilig as affect enveloped in a coming-of-age narrative. By deploying Wilton (the lesbian as subject position) and Berlant (fantasy/desire), I will discuss how Billie and Emma (2018) subverts the lens of heterosexuality/heteronormativity seen in most lesbian films both in the western …
(Ba)Ding, Ang Bato!: Queering Duterte's Drug War In Jun Lana's Big Night! (2021), Jenno Roquero
(Ba)Ding, Ang Bato!: Queering Duterte's Drug War In Jun Lana's Big Night! (2021), Jenno Roquero
Akda: The Asian Journal of Literature, Culture, Performance
Though there are studies around Duterte’s war on drugs and human rights violations, scholarship focusing on the relationship between Duterte’s politics and gender, particularly queerness and kabaklaan, is limited despite his frequent derogatory use of bakla, gay, or homosexual to demean rivals and critics. This article analyzes Jun Lana’s Big Night! (2021) through the Filipino concept of batak—intoxication, being forcibly dragged, and musculature—to examine the intersections of queerness, state violence, and survival in Rodrigo Duterte’s “War on Drugs.” Through close readings of key scenes, the article maps how batak operates as a framework for understanding the bakla’s shifting position: …
Ang Kasama: Agapay Na Sanaysay Sa Librong Kampuhan (The Comrade: A Companion Essay To The Book Kampuhan), Ma. Cecilia C. De La Rosa
Ang Kasama: Agapay Na Sanaysay Sa Librong Kampuhan (The Comrade: A Companion Essay To The Book Kampuhan), Ma. Cecilia C. De La Rosa
Akda: The Asian Journal of Literature, Culture, Performance
Ang sanaysay na ito ay mungkahing pagbasa ng aking librong Kampuhan (2024), koleksyon ng 55 tula tungkol sa buhay ng mga rebolusyonaryo sa isang lihim na kampo. Hango sa komponenteng poetika ng aking tesis masterado na may parehong pamagat, ang sanaysay ay pinaikling bersyon ng seksyong tumututok sa Teorya ng Comrade ni Jodi Dean (2020) bilang balangkas at perspektiba sa pag-unawa sa mga persona at bagay at sa kaligiran nila sa mga tula.
Hinahapag ni Dean ang Comrade bilang lagom ng praktis ng komunismo at unyonismo sa buong mundo sa pamamagitan ng apat na tesis ng kasama na nagpapagitaw sa …
Biliverdin Reductase A Is A Major Determinant Of Protective Nrf2 Signaling, Chirag Vasavda, Ruchita Kothari, Navneet Ammal Kaidery, Suwarna Chakraborty, Sunil Jamuna Tripathi, Ryan S Dhindsa, Cristina Ricco, Shruthi Shanmukha, Samaneh Saberi, Julia E Lefler, Priyanka Kothari, Kalyani Chaubey, Adele M Snowman, Michael C Ostrowski, Eugenio Barone, Lakshminarayan M Iyer, L Aravind, Sudarshana M Sharma, Andrew A Pieper, Bobby Thomas, Solomon H Snyder, Bindu D Paul
Biliverdin Reductase A Is A Major Determinant Of Protective Nrf2 Signaling, Chirag Vasavda, Ruchita Kothari, Navneet Ammal Kaidery, Suwarna Chakraborty, Sunil Jamuna Tripathi, Ryan S Dhindsa, Cristina Ricco, Shruthi Shanmukha, Samaneh Saberi, Julia E Lefler, Priyanka Kothari, Kalyani Chaubey, Adele M Snowman, Michael C Ostrowski, Eugenio Barone, Lakshminarayan M Iyer, L Aravind, Sudarshana M Sharma, Andrew A Pieper, Bobby Thomas, Solomon H Snyder, Bindu D Paul
Duncan NRI Faculty and Staff Publications
Biliverdin reductase A (BVRA), the terminal enzyme in heme catabolism, generates the neuroprotective and lipophilic antioxidant bilirubin. Here, we identify a nonenzymatic role for BVRA in redox regulation. Through phylogenetic, genetic, biochemical, and enzymatic assays, we found that BVRA exerts critical nonenzymatic antioxidant activity. Transcriptomic analyses further revealed that BVRA physically and genetically interacts with nuclear factor erythroid-derived factor-like 2 (NRF2), a major transcriptional regulator of cellular redox signaling. ChIP-seq and RNA-seq analyses reveal that BVRA and NRF2 coordinate the expression of antioxidant genes, many of which are typically dysregulated in neurodegenerative conditions such as Alzheimer's disease. Thus, this noncanonical …
Genetics-Nutrition Interactions Control Diurnal Enhancer-Promoter Dynamics And Liver Lipid Metabolism, Dishu Zhou, Ying Chen, Panpan Liu, Kun Zhu, Juliet Holder-Haynes, S Julie-Ann Lloyd, Cam Mong La, Inna I Astapova, Seunghee Choa, Ying Xiong, Hosung Bae, Marlene Aguilar, Hongyuan Yang, Yu A An, Zheng Sun, Mark A Herman, Xia Gao, Liming Pei, Cholsoon Jang, Joshua D Rabinowitz, Samer G Mattar, Yongyou Zhang, Dongyin Guan
Genetics-Nutrition Interactions Control Diurnal Enhancer-Promoter Dynamics And Liver Lipid Metabolism, Dishu Zhou, Ying Chen, Panpan Liu, Kun Zhu, Juliet Holder-Haynes, S Julie-Ann Lloyd, Cam Mong La, Inna I Astapova, Seunghee Choa, Ying Xiong, Hosung Bae, Marlene Aguilar, Hongyuan Yang, Yu A An, Zheng Sun, Mark A Herman, Xia Gao, Liming Pei, Cholsoon Jang, Joshua D Rabinowitz, Samer G Mattar, Yongyou Zhang, Dongyin Guan
Faculty, Staff and Student Publications
The circadian clock controls 24-h rhythmic processes. However, how genetic variations outside clock genes impact peripheral diurnal rhythms remains largely unknown. Here, we find that genetic variation contributes to different diurnal patterns of hepatic gene expression in both humans and mice. Nutritional challenges alter the rhythmicity of gene expression in mouse liver in a strain-specific manner. Remarkably, genetics and nutrition interdependently control more than 80% of rhythmic gene and enhancer-promoter interactions (E-PIs), with a noncanonical clock regulator, estrogen-related receptor gamma (ESRRγ), emerging as a top transcription factor during motif mining. Knockout of Esrrγ abolishes strain-specific metabolic processes in response to …
Fiber Recruitment Drives A Phase Transition Of Cell Polarization At A Critical Cell Spacing In Matrix-Mediated Tissue Remodeling, Xiangjun Peng, Yuxuan Huang, Wenyu Kong, Yanan Du, Elliot L Elson, Xi-Qiao Feng, Guy M Genin
Fiber Recruitment Drives A Phase Transition Of Cell Polarization At A Critical Cell Spacing In Matrix-Mediated Tissue Remodeling, Xiangjun Peng, Yuxuan Huang, Wenyu Kong, Yanan Du, Elliot L Elson, Xi-Qiao Feng, Guy M Genin
2020-Current year OA Pubs
Biological tissues exhibit sharp phase transitions where cells collectively transition from disordered to ordered states at critical densities. We demonstrate through bio-chemo-mechanical modeling that this emergent behavior arises from a nonmonotonic dependence on nonlinear extracellular matrix (ECM) mechanics: mechanical communication between cells is optimized at intermediate stiffness values where cells can both generate sufficient forces and create strain-stiffened tension bands in the ECM. This balance establishes a critical cell spacing threshold for cell-cell communication ([Formula: see text]100 to 200 [Formula: see text]m) that is conserved across experimental observations for a broad range of cell types and collagen densities. Our model …