Digital Commons Network^™

Genetics-Nutrition Interactions Control Diurnal Enhancer-Promoter Dynamics And Liver Lipid Metabolism, Dishu Zhou, Ying Chen, Panpan Liu, Kun Zhu, Juliet Holder-Haynes, S Julie-Ann Lloyd, Cam Mong La, Inna I Astapova, Seunghee Choa, Ying Xiong, Hosung Bae, Marlene Aguilar, Hongyuan Yang, Yu A An, Zheng Sun, Mark A Herman, Xia Gao, Liming Pei, Cholsoon Jang, Joshua D Rabinowitz, Samer G Mattar, Yongyou Zhang, Dongyin Guan

Faculty, Staff and Student Publications

The circadian clock controls 24-h rhythmic processes. However, how genetic variations outside clock genes impact peripheral diurnal rhythms remains largely unknown. Here, we find that genetic variation contributes to different diurnal patterns of hepatic gene expression in both humans and mice. Nutritional challenges alter the rhythmicity of gene expression in mouse liver in a strain-specific manner. Remarkably, genetics and nutrition interdependently control more than 80% of rhythmic gene and enhancer-promoter interactions (E-PIs), with a noncanonical clock regulator, estrogen-related receptor gamma (ESRRγ), emerging as a top transcription factor during motif mining. Knockout of Esrrγ abolishes strain-specific metabolic processes in response to …

Scientific Authority In The Public Sphere: The Heroic Legacies Of Carl Sagan And Philip Zimbardo, Scott T. Allison

Heroism Science

This article examines the parallel trajectories of Carl Sagan and Philip Zimbardo as scientists who assumed the role of public intellectuals. Their careers highlighted the tensions and opportunities inherent in bridging scholarly research and public engagement. Sagan, an astronomer, popularized the cosmic perspective to promote planetary stewardship, while Zimbardo, a social psychologist, used compelling methodologies to explore the psychological underpinnings of cruelty and heroism. Both were, in their own ways, heroic in their commitment to making science accessible, employing storytelling and mass media to render complex concepts understandable and relevant, thereby expanding the societal relevance of their disciplines. However, their …

Undoing Gender Performativities In Nawal El Saadawi’S Woman At Point Zero, Tobe Levin Von Gleichen, U. H. Ruhina Jesmin, Tasnuva Khair

Journal of International Women's Studies

Physician, psychiatrist, and Marxist activist for women’s rights, Nawal El Saadawi (1931-2021) published fiction and non-fiction exposing how a capitalistic, phallocratic social order keeps Egyptian women in thrall to men through violent suppression. Women are exploited by men, who see women as weak and prey on these presumed docile subordinates in a display of masculinity. Deciphering the effects of this gendered performativity through the lens of Judith Butler, El Saadawi’s novel Woman at Point Zero (1977/2015a), or Ferdaous, une Voix en Enfer (El Saadawi, 1977/2007) in French, provides a narrative whose significance is amplified by Butlerian theory. The protagonist, …

Animation Film Industry Of India And Service Design: A Systematic Review Of Literature, Abhishek Kumar, Dr. Shikha Rai, Dr. Sonali Srivastav

ServDes Conference Series

The medium of animation transcends the physical limitations posed by other visual media, combining elements of fantasy with realism. By 2030, the animation business in India is expected to grow from ₹215.8 billion to ₹1.21 trillion. The major companies that dominate this segment in India are Disney and Pixar. The fact that the top 10 highest-grossing animation films in India are all produced by international companies, with ‘Kung Fu Panda 4(2024)’ at the top further demonstrating this foreign domination. Compared to its global counterparts, the Indian animation industry is yet to see the boom, despite the market accepting the medium. …

Resilient By Design: The Dissolution Of Alternative Food Networks, Cagri G. Varli, Stefano Maffei

ServDes Conference Series

Alternative food networks (AFNs) are often presented through peak-period success stories, leaving their entire lifecycle — transformations, challenges, and reconfigurations — underexplored. By rethinking AFN dissolution process through a service design lens, this study examines how embedded values, networks, and operational models evolve beyond their initial structures. The research uses a new generation consumer cooperative as a case study, and it employs multiple sources of evidence — semi-structured interviews, archival data, media sources, and direct observations — to analyze the cooperative’s evolution. Findings reveal how AFNs transition from grassroots initiatives to structured models but struggle with economic constraints and governance …

Redesigning Equine Air Transport: A Product-Service System To Empower The Horse-Owner Alliance, Paola Maria Trapani, Ke Ma, Jiao Mo

ServDes Conference Series

Equine air transport poses significant health, and welfare risks due to stress and environmental factors. Current systems lack proactive solutions, leading to preventable health issues like Shipping Fever (SF) and poor service experiences. Design Challenge: This research explores how Product-Service System Design (PSSD) can mitigate common transport challenges, enhance stakeholder experiences, and reposition the Horse-Owner Alliance (HOA) as a key player. Methods: Using a mixed-methods approach, the study examined system, service, and product levels, integrating UX/UI, product design, and PSSD methods, alongside elements of System Design. Prototypes—including a smart stall and a wearable halter—were tested in real-world settings. Results: The …

Tracing Human-Ai Relations: A Participatory Approach To Genai Integration In Creative Public Service Work, Sanna Marttila, Louise Harder Fischer, Sunniva Sandbukt

ServDes Conference Series

This paper examines a participatory process for integrating Generative AI (GenAI) into the creative work of a public service organization. Through this process, we gain insights into the complexities of human-AI relations, the evolving nature of creative work, and the conditions necessary for meaningful AI integration in service organizations. The paper makes two key contributions: it documents a case of participatory GenAI integration in a public service setting, and it explores implications for creative practice and the evolving role of human-AI collaboration. Findings highlight the importance of reflection, value-driven AI integration, and the need for facilitated spaces for critical reflection. …

Animal-Centered Service Design For Stray Animals In India, Faiza Khan, Shamit Shrivastav

ServDes Conference Series

According to the State of Pet Homelessness Index data of 2021, India has a high prevalence of stray animals, with around 80 million homeless cats and dogs. The living conditions of these animals are harsh and unsafe. Services for stray animals are managed by the animal welfare departments, non-profit organizations, and caretakers. The objective of this study is to investigate the efficacy of existing stray animal welfare services and understand the role of the stakeholders towards creating a safe and healthy environment for these animals. Semi-structured interviews of eighteen stakeholders and site immersions at five Mumbai-based NGOs were conducted. The …

Bat Observation During A Solar Eclipse In Georgia, Dalton C. Brantley, Graham B. Moore, Catherine H. Borer

Georgia Journal of Science

Eclipses are astronomical phenomena that occur infrequently enough, either spatially or temporally, that for most animals, experiencing an eclipse may only happen once in a lifetime. Thus, an eclipse can provide a unique combination of meteorological and environmental conditions, through which animal behavior can be evaluated. In this study we observed and documented bat behavior (order Chiroptera) in northwest Georgia during a partial solar eclipse in 2024. Using passive acoustic monitors at locations recognized as high quality bat habitat, we detected a single hoary bat (Lasiurus cinereus) 5 minutes before the solar eclipse peak. The bat was first …

An Overview Of The European Eel Anguilla Anguilla Fisheries In Egypt, Azza A. El Ganainy, Mohamed S. Ahmed, Mohamed F. Osman, Amany A. Mahmoud

Blue Economy

The main objective of this study is to give for the first time an overview of the geographic, seasonal and intraspecific variations in European eel (Anguilla Anguilla) stock in the Egyptian different habitats. The geographical distribution, general status as well as stocks temporal variation in Egypt are analyzed examining long term catch data sets. European eels are found in the Nile Delta and along the Mediterranean coast, occupying the brackish northern lagoons (Edko, Burullus, Manzala) and the hyper saline Bardawil lagoon. Annual total eel landings from 2013 to 2022 fluctuated, with a maximum of 1268 tons recorded in Burullus Lagoon …

In Vitro Screening Of Antibacterial Efficacy Of Moringa Oleifera And Thymus Vulgaris Methanolic Extracts Against Different Escherichia Coli Strains And Their In Vivo Effects Against E. Coli-Induced Infection In Broiler Chickens, Majid Ali, Naila Chand, Sarzamin Khan, Rifat Ullah Khan, Babar Maqbool, Shabana Naz, Ala Abudabos, Abdul Hafeez, Ibrahim A. Alhidary

Food and Animal Sciences Faculty Research

This study evaluated the antibacterial efficacy and growth-promoting potential of Moringa oleifera and Thymus vulgaris methanolic extracts in broiler chickens challenged with Escherichia coli O78. In vitro antibacterial screening using agar well diffusion and disc diffusion assays revealed that ciprofloxacin exhibited the strongest inhibitory effect, followed by tetracycline and enrofloxacin, whereas among plant extracts, T. vulgaris was more effective than M. oleifera. The optimal combination (M100T150; 100 mg M. oleifera + 150 mg T. vulgaris) produced the largest inhibition zones against E. coli strains. For the in vivo trial, 540 Ross-308 broiler chicks were distributed into six treatment groups in …

Alloplastic Implants For Rhinoplasty: A Systematic Review And Meta-Analysis Of Clinical Outcomes And Complications, Rafeni Bunga Cikita, Beta Subakti Nataadmaja

Folia Medica Indonesiana

Alloplastic implants emphasize the importance of a comprehensive understanding of both clinical and histological aspects, which are attributed to enhancing patient satisfaction and surgical success rates. The study aims to assess the viability of different implant materials and their related risks over time. A systematic literature search was conducted across multiple databases, including PubMed, Cochrane, and EBSCOhost, to identify 79 records. After eliminating duplicates and applying specific inclusion and exclusion criteria, four new studies were included for evaluation, focusing on postoperative outcomes related to alloplastic implants in rhinoplasty. Late-onset inflammation in non-healthy capsules required removal and showed histological damage. One …

Climate Change: The World In Uncharted Waters – Exploring The Nexus Of Human-Rights Based Legal Instruments And Climate Change, Emma V. Wilson

Richmond Public Interest Law Review

The framework of human rights is based on a “fundamental and irrevoca- ble belief in the dignity and worth of every individual.”! While many differ- ent channels have emerged for protecting human rights in the face of global climate change, there is still significant room for improvement. For decades, there was no formal recognition of human-centered environmental rights.? The recent United Nations General Assembly (“UNGA”) acknowledgement of a right to a clean, healthy, and sustainable environment is a tool that can “facilitate the reconceptualization of human rights law to better adapt to the negative impacts of climate change.” It represents …

Perceptions Of Whole Plant-Based Diets And Weight Among Hispanics In Miami, Florida, Zoraida Powell

Walden Dissertations and Doctoral Studies

Being overweight or obese poses major public health concerns and contributes to the development of chronic illnesses. While researchers have explored how a total plant-based diet impacts excess body weight or obesity, there is still a lack of clarity about how Hispanics living in Miami, FL, perceive or understand this diet concerning overweight and obesity. Using a generic qualitative approach, this study was conducted on how Hispanics in Miami, FL, understand and view a whole plant-based diet (WPBD) for preventing and reducing overweight and obesity. Through interviews with 14 diverse Hispanic participants, the study revealed that they see WPBD as …

The Free Press Vol. 57, Issue 4, 10-06-2025, Julz Levesque, Caraline Squires

Free Press, The

Shutdown Stalemate--College Dreams at Risk--The Portland Farmer's Market Is in Full Bloom--First Pingo of the School Year--Common Ground Country Fair--USM Honors POW-MIA Recognition Day with Flag Raising Ceremony

Lanthorn, Vol. 60, No. 05, October 6, 2025, Grand Valley State University

Volume 60, August 4, 2025 – April 20, 2026

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Consciousness Below Scuba Depths, Michael Vecchione

Animal Sentience

Abstract: Jennifer Mather has nicely summarized what is known about consciousness in shallow water octopods as well as what is known about shallow water squids and cuttlefish. However, once she gets below SCUBA depths, she misses out on most of cephalopod diversity. I have attempted to add this aspect and perhaps some evolutionary biology to this target article.

Ndls Communicator: Week Of 10.06.25, Notre Dame Law School

NDLS Communicator

The Latest News

• Faculty profile: Professor Mary Ellen O'Connell, globally influential scholar of international law and peace
• Panel explores Catholic Social Teaching and human rights in Africa

Faculty Briefs

• Nicole Garnett
• Sadie Blanchard
• Patrick Corrigan
• Roger Alford
• Mary Ellen O'Connell
• Christine Venter
• Paolo Carozza
• Avishalom Tor
• Emily Bremer
• Fr. John Paul Kimes
• Derek Muller
• Judy Fox
• Gerard Bradley

ND Law in the News

• Notre Dame Law School's partnership with Harvey AI was featured in a Law360 article.

Student News

• Third-year law student Dennis Weiboldt III wrote an article for First Things Magazine about the Red Mass

Events

• Law and Economics …

Intouch Week Of October 6, 2025, New York Medical College

InTouch

• NYMC Goes Pink for Breast Cancer Awareness Month
• Summer Research Fellowships Empower Medical Students to Explore, Innovate, and Lead
• International Symposium on Adolescent and Young Adult NHL Has Far Reach
• A Look Inside NYMC with the 2025-2026 Social Media Ambassadors
• SOM Welcomes New Faculty
• Pet the Stress Away Brings Joy to NYMC
• Stay Warm with Savings on Hoodies
• In The Community: College Joins Forces at Westchester Heart Walk to Fight Heart Disease and Stroke
• In The Community: SHSP Students and Faculty Partner with the White Plains Youth Bureau for Community Health and Wellness Day
• Faculty Spotlight: Christopher Whitehurst, Ph.D., Cracks …

Atg16l1 Controls Mammalian Vacuolar Proton Atpase, Thabata L A Duque, Masroor Paddar, Einar Trosdal, Ruheena Javed, Lee Allers, Michal H Mudd, Prithvi Akepati, Soumya R Mishra, Michelle Salemi, Brett Phinney, Shawn B Bratton, Thomas Wileman, Vojo Deretic

Faculty, Staff and Student Publications

The mechanisms governing mammalian proton pump V-ATPase function are of fundamental and medical interest. The assembly and disassembly of cytoplasmic V1 domain with the membrane-embedded V0 domain of V-ATPase is a key aspect of V-ATPase localization and function. Here, we show that the mammalian protein ATG16L1, primarily appreciated for its role in canonical autophagy and in noncanonical membrane atg8ylation processes, controls V-ATPase. ATG16L1 knockout elevated V-ATPase activity, increased V1 presence on endomembranes, and increased the number of acidified intracellular compartments. ATG16L1's ability to efficiently bind V-ATPase was required for its inhibitory role in endolysosomal acidification and for control of Mycobacterium …

Apoe-Calypse Tau: Apoe-Tau Synergy In Alzheimer's Disease, Matthew Paul Lennol, Chiara Bordier, Léana Kamelher, Jason D Ulrich, David M Holtzman, Maud Gratuze

2020-Current year OA Pubs

Alzheimer's disease (AD), the most common cause of dementia, is characterized by the accumulation of amyloid-β (Aβ) in senile plaques and abnormally hyperphosphorylated tau proteins in neurofibrillary tangles. While much of the research has focused on Aβ, tau-mediated neurodegeneration is more closely associated with synaptic loss and cognitive decline in AD, emphasizing the need for a deeper understanding of tau pathology. In this context, the interaction between tau and APOE, particularly the main genetic risk factor for AD APOE ε4, remains underexplored. APOE encodes apolipoprotein E (apoE), a protein important in lipid metabolism. In addition to promoting Aβ deposition, emerging …

Atg Conjugation-Dependent/Independent Mechanisms Underlie Lysosomal Stress-Induced Tfeb Regulation, Shiori Akayama, Takayuki Shima, Tatsuya Kaminishi, Mengying Cui, Jlenia Monfregola, Kohei Nishino, Andrea Ballabio, Hidetaka Kosako, Tamotsu Yoshimori, Shuhei Nakamura

Duncan NRI Faculty and Staff Publications

TFEB, a master regulator of autophagy and lysosomal biogenesis, is activated by several cellular stresses including lysosomal damage, but its underlying mechanism is unclear. TFEB activation during lysosomal damage depends on the ATG conjugation system, which mediates lipidation of ATG8 proteins. Here, we newly identify ATG conjugation-independent TFEB regulation that precedes ATG conjugation-dependent regulation, designated Modes I and II, respectively. We reveal unique regulators of TFEB in each mode: APEX1 in Mode I and CCT7 and/or TRIP6 in Mode II. APEX1 interacts with TFEB independently of the ATG conjugation system, and is required for TFEB stability, while both CCT7 and …

Engagement By Design: Belongingness, Cultural Value Orientations, And Pathways Into Emerging Technologies, Daisuke Akiba, Michael Perrone, Caterina Almendral, Rebecca Garte

Publications and Research

This theoretical article examines how belongingness, defined as the sense that one’s participation is legitimate and valued, interacts with cultural value orientations to help explain persistent disparities in U.S. technology engagement, including emerging technologies, across racial and ethnic groups. While structural barriers (e.g., racism, poverty, linguistic bias, etc.) remain essential to understanding such inequity, we argue that engagement patterns in technology also reflect how different cultural communities may define and experience belongingness in relation to digital domains. Drawing on Triandis and Gelfand’s framework, and focusing specifically on educational contexts, we propose the Belongingness through Cultural Value Alignment (BCVA) model, whereby …

25 Conference Program - Integrated Continuous Biomanufacturing Vii, Kevin Brower, Alois Jungbauer, Mark Brower, Irina Ramos

Integrated Continuous Biomanufacturing VII (ICB VII)

No abstract provided.

Ronald Crutcher, Cello, Department Of Music, University Of Richmond

Music Department Concert Programs

No abstract provided.

What On Earth Is A Burden On Interstate Commerce?, Andrew Jordan

Northwestern University Law Review

What is a burden on interstate commerce? That’s an important question under the Dormant Commerce Clause’s Pike balancing test. But it’s a question whose answer has proven elusive. This shouldn’t be a surprise. After all, states disagree about what counts as a burden or a benefit, and how much weight each has. And there aren’t any obvious constitutional principles we can point to for resolving those disagreements. Recently, some scholars have tried to ground dormant commerce doctrine in economic cost–benefit analysis. The supposed virtue of that approach is that it is neutral as to competing preferences. Thus, for the Court …

Neuronal Mct2 Promotes Angiogenesis Via Lactate In The Developing Mouse Neocortex, Daehoon Lee, Anika Wu, Lingling Yao, Shreya Satish, Lin Mei, Wen Cheng Xiong

Faculty Scholarship

Neural activity drives blood vessel (BV) formation and energy substrate delivery in the developing brain to meet rising metabolic demands; however, the underlying mechanisms remain poorly understood. In this study, we exposed neonatal mice to chronic whisker stimulation (WS), a paradigm known to enhance BV formation in the somatosensory (S1) cortex. Transcriptomic (RNA-seq) and spatial (RNA-scope) analyses revealed that WS upregulated monocarboxylate transporter 2 (MCT2) in cortical neurons and MCT1 in endothelial cells (ECs). These changes coincided with increased cortical lactate levels, elevated astrocytic vascular endothelial growth factor A (VEGFa), and enhanced angiogenesis. Functional experiments demonstrated that neuronal MCT2 is …

Remedies For Unreasonable Administrative Action After Vavilov, Kate Glover Berger

Articles & Book Chapters

This article comments on Pepa v. Canada (Citizenship and Immigration), arguing that it departs from the Supreme Court's previous guidance on remedies in an unprincipled manner. The article outlines the remedial framework established in Canada (Minister of Citizenship and Immigration) v. Vavilov, traces its development over the past five years, discusses key departures from the general rule of remittal, and highlights the principles these departures reflect. It then examines the approach to remedies adopted in Pepa. This assessment shows that the Pepa majority's invocation of the "single reasonable interpretation" exception to the general rule of remittal departs from the core …

Perioperative Repercussions Of Cannabis Use-Implications For Gi Endoscopy Sedation, Basavana Goudra, Michael Green

Department of Anesthesiology Faculty Papers

The legalization of cannabis in multiple U.S. states and several other countries, along with its increasing social acceptance across diverse demographic and socioeconomic groups, has led to a growing number of patients presenting for interventional procedures with a history of cannabis use. Although anesthetic and sedation-related implications may be less pronounced than in major surgery, they remain clinically relevant and warrant careful consideration. Key factors include acute intoxication, chronic use, and cannabis use disorder. Cannabis users often require higher-and sometimes unpredictable-doses of propofol and other sedatives. Inhalational use is associated with airway hyperreactivity, increasing the risk of bronchospasm and, in …

Secure Gif Files Based On Zuc Stream Cipher And Present Algorithm, Suhad Fakhri Hussein

Al-Esraa University College Journal for Engineering Sciences

Some important security needs include authentication, confidentiality, integrity, non-repudiation, and user privacy. Many security systems include these required protections for information transmission. The encryption process is one of the most important security measures. Many secure encryption algorithms are based on different keys and key lengths to ensure a high degree of security. GIF file format is common file format that is used in several application, securing these files through transmission is imperative. In this paper, an efficient method for encryption GIF file is proposed based on using modified present algorithm, modified ZUC stream cipher, and an efficient method for key …