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2025

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October 23, 2025, The Daily Mississippian Oct 2025

October 23, 2025, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.


A Critical Alteration In Enolase Is Identified In One Isolate Of Staphylococcus Aureus To Avoid Host Immunity, Ban M. Abdulhadi, Halah H Al-Haideri Oct 2025

A Critical Alteration In Enolase Is Identified In One Isolate Of Staphylococcus Aureus To Avoid Host Immunity, Ban M. Abdulhadi, Halah H Al-Haideri

Baghdad Science Journal

The ability of Staphylococcus aureus enolase to cleave plasminogen has been thought to be important for bacterial virulence. The genetic variants of Eno gene sequences were investigated in the present study to assess the pattern of biological diversity of one isolate of S. aureus isolated from patients with diabetic food from Iraqi hospitals. The observed variant’s possible impact in altering the enolase’s binding with its receptor was assessed by docking with plasminogen before and after mutation. Within the locus 791st, two variations were identified with two different consequences since A>T791 (in S2, S3, S14, and S17) and …


Continuous Flow Injection-Turbidimetric Analysis For Determination Of Cobalt (Ii) Ion In Alloys Using A Microcell With Irradiation Sources At 0–180° Using A Single Solar Cell As A Detector, Murtadha Hadi Athab, Nagham Shakir Al-Awadi Oct 2025

Continuous Flow Injection-Turbidimetric Analysis For Determination Of Cobalt (Ii) Ion In Alloys Using A Microcell With Irradiation Sources At 0–180° Using A Single Solar Cell As A Detector, Murtadha Hadi Athab, Nagham Shakir Al-Awadi

Baghdad Science Journal

A cost-effective and efficient detector was created to conduct thorough turbidimetric measurements by reaction of Co (II) ion with calcium ferro cyanide to form bright green particulate, using the method of continuous flow injection analysis, the use of NAG-5SX1-1D-SSP Analyzer in determining cobalt (II) ion in a test for the validity of the new design. The NAG-5SX1-1D-SSP Analyzer is composed of five irradiation sources of white snow leds having the diameter of 10 mm with one solar cell of 55 mm length, 13.5 mm width. Using a selector switch to select the optimum voltage to be used which was 2.7 …


New Mode For 4 Mm Path Irradiation And One Side Detection At 0–180° For Cu (Ii)Ion Determination In Different Samples Using On-Line Continuous Flow Feed And Simplified, Sensitive, And Portable Photometer, Asma A. Gayed Al-Ani, Nagham S. Turkey Al-Awadie Oct 2025

New Mode For 4 Mm Path Irradiation And One Side Detection At 0–180° For Cu (Ii)Ion Determination In Different Samples Using On-Line Continuous Flow Feed And Simplified, Sensitive, And Portable Photometer, Asma A. Gayed Al-Ani, Nagham S. Turkey Al-Awadie

Baghdad Science Journal

This study presents a rapid, sensitive, and straightforward approach for measuring Cu(II) ions using turbidity continuous flow injection analysis (CFIA) . The method involves reacting Cu(II) ion with calcium Ferro cyanide to produce a brown-red precipitate. To detect the attenuation of incident light as a result of collision on the surfaces of the precipitate particles, the analyzer NAG-SSP-5S-1D was used to measure turbidity at an angle (0–180°).

The linear range of Cu(II) measurements extends from 0.01 to 5 mmol.L–1 with Correlation Coefficient of 0.9993 and R2 % = 99.86 .The limit of detection (LOD) was determined to be …


Azo-Schiff Type Ligands Derived From Curcumin And Their Complexes With Transition Metals, Synthesis, Characterization And Bioactivity Studies, Fatima Rasheed Ali, H. A. Hassan Oct 2025

Azo-Schiff Type Ligands Derived From Curcumin And Their Complexes With Transition Metals, Synthesis, Characterization And Bioactivity Studies, Fatima Rasheed Ali, H. A. Hassan

Baghdad Science Journal

In this work the precursor (W1) 2,2'-((1E,1'E)-(4,4'-diamino-5,5'-dimethyl-[1,1'-biphenyl]Diazene-2,1-diyl-3,3’-diyl)-bis((E)-pyridin-3-yldiazenyl)-[1,1'-biphenyl] or (W2) 3,3'-dimethyl-5,5'-bis((E)-pyridin-3-yldiazenyl)-[1,1'-biphenyl] -4,4'-diamine respectively were obtained from the reaction of 2-aminophenol or 2-aminopyridine with toluidine, respectively. Subsequently, these precursors were used for the synthesis of two ligands using the azo compounds (W1) or (W2) and curcumin to produce [H4L1] 4,4',4'', 4'''-((1E,1'E,6E,6'E)-((3,3'-bis((E)-(2-hydroxyphenyl)diazenyl)-5,5'-dimethyl-[1,1'-bi phenyl]-4,4'-diyl)bis(azaneylylidene))bis(5-hydroxyhepta-1,6-diene-1,7-diyl-3-ylidene))bis(azaneylylidene))bis(aza -neylylidene))tetrakis(2-methoxyphenol) or [H2L2] 4,4',4'',4'''-((3,3'-dimethyl-,4,4'-diyl)bis- (azaneylylidene))bis(5-hydroxyhepta-1,6-diene-1,7-diyl-3-ylidene))tetrakis(2-methoxyphenol). The prepared ligands were characterized by F.T-I.R, U.V, 1H-NMR,13C-NMR spectroscopy. This work also included the preparation of complexes through the reaction of ligands with the metal …


Development And Integration Of A Molecularly Imprinted Determination Atenolol In Pharmaceutical Samples Based On Solid Phase Extraction, Hamsa S. Omaish, Yehya K. Al-Bayati Oct 2025

Development And Integration Of A Molecularly Imprinted Determination Atenolol In Pharmaceutical Samples Based On Solid Phase Extraction, Hamsa S. Omaish, Yehya K. Al-Bayati

Baghdad Science Journal

The current investigation aims to display that bulk polymerization of Atenolol (Ate) can synthesize and store molecular-imprinted polymers (MIP) at room temperature. It is indicated that such an environment has various advantages, including higher sensitivity, lower costs, higher stability, and longer life. To guarantee appropriate adsorption capacity, 0.99:6:20 mmol ratios of template, monomer, and cross-linking agents are employed for polymerization. To start the functional monomer styrene (C8H8) bonding Ethylene glycol dimethacrylate (EGDMA) C10H14O4, the researcher employed benzoyl peroxide (BPO). Accordingly, MIP is created for Atenolol (Ate-MIP), which can be detected for pharmaceuticals employing UV-visible spectrophotometry at 276 nm for drugs. …


Preparation, Characterization, And Studying The Biological Activity Of Schiff Base Metal Complexes Derived From Cephalexin With 3-Methoxy-4-Hydroxy Benzaldehyde, Jenan F. Hassan, Sahar S. Hassan Oct 2025

Preparation, Characterization, And Studying The Biological Activity Of Schiff Base Metal Complexes Derived From Cephalexin With 3-Methoxy-4-Hydroxy Benzaldehyde, Jenan F. Hassan, Sahar S. Hassan

Baghdad Science Journal

The Schiff base reaction between Cephalexin (CFX). (7R)-3-Methyl-7- (α- D -phenylglycylamino) -3-cephem-4-carboxylic acid (C16H17O4N3S) and vanillin C8H8O3 [ 3-methoxy -4-mydroxybenzaldehyde] was carried out resulting in ligand C26H27N3O6S (L). In turn, reacted with the next metal ions (Cobalt (II), Nickel (II), Copper (II), Zinc (II), and Cadmium (II)), forming stable complexes with unique geometries such as (Octahedral for Ni+2, Cu+2, Zn+2&Cd+2, Tetrahedral for Co+2). The complexes were identified using …


The Influence Of Solvent, Concentration, And Temperature On The Resolution Of Protons Signals Of 1H Nmr Spectra Of 1,2,3-Triazole-Tethered Glucopyranose, Rasha Saad Jwad Oct 2025

The Influence Of Solvent, Concentration, And Temperature On The Resolution Of Protons Signals Of 1H Nmr Spectra Of 1,2,3-Triazole-Tethered Glucopyranose, Rasha Saad Jwad

Baghdad Science Journal

Triazoles linked to carbohydrate molecules are one of the most important compounds that have wide applications in the pharmaceutical, biological, and materials science fields. Many of these compounds have been prepared and their structural, chemical, and physical properties have been studied. One of the best techniques used to study and interpret these properties is nuclear magnetic resonance NMR spectroscopy. For this purpose, the simplest glucose-based 1,2,3-triazole derivative 5 has been prepared from D-glucose in four consecutive steps. First, the reaction of glucose with acetic anhydride in the presence of sodium acetate afforded 1,2,3,4,6-penta-O-acetyl-β-D-glucopyranose (2) …


Seasonal Variation Of Phytoplankton And Zooplankton Biomass In Correlation With Physio-Chemical Variables Of Some Water Bodies In Dolly Smaquli, Erbil, Iraq, Sana Kayfi Najmadden, Luay Abdul-Qadir Ali Oct 2025

Seasonal Variation Of Phytoplankton And Zooplankton Biomass In Correlation With Physio-Chemical Variables Of Some Water Bodies In Dolly Smaquli, Erbil, Iraq, Sana Kayfi Najmadden, Luay Abdul-Qadir Ali

Baghdad Science Journal

The seasonal variation of phytoplankton and zooplankton groups in correlation with physio-chemical variables has been examined by monthly water samples from eight distinct locations in Smaquli Dam and Streams within Dolly Smaquli in Erbil city, Iraq. The sampling time spans from September 2021 to August 2022. Nineteen physical and chemical variables were examined including Air and water temperature, Electrical conductivity (EC), Total dissolved solids (TDS), Turbidity, pH, Dissolved oxygen (DO), Biochemical oxygen demand (BOD5), Total Alkalinity, Total Hardness, Nitrite (NO2), Nitrate (NO3), Reactive phosphate (PO4), Ca+2, Mg+2, Na …


Cadmium Removal From Aqueous Solutions Facilitated By Biochar Derived From Active Sewage Sludge, Aya L. Khalil, Faris H. Al-Ani, Abdul Hameed M. J. Al-Obaidy Oct 2025

Cadmium Removal From Aqueous Solutions Facilitated By Biochar Derived From Active Sewage Sludge, Aya L. Khalil, Faris H. Al-Ani, Abdul Hameed M. J. Al-Obaidy

Baghdad Science Journal

Biochar was previously confined to agriculture applications, but its utilization has since expanded across various sectors. In this case, sludge acquired from a sewage treatment facility was employed in the production of biochar. The study investigates the adsorption of cadmium in aqueous solution by both untreated biochar and biochar treated with H3PO4, examining the influence of adsorbent dosage, contact time, pH, and initial concentration. Phosphorus compounds present on the biochar surface activate it, enhancing cadmium removal compared to untreated biochar. The experimental results showed that the optimal dosage (1000 mg/l) and adsorption rate were significantly affected …


Effect Of The Atmospheric Stability On Wind Energy Density Using Similarity Theory, Jafar Mohammed Khadir, Basim Abdulsada Al-Knani, Ahmed F. Hassoon Oct 2025

Effect Of The Atmospheric Stability On Wind Energy Density Using Similarity Theory, Jafar Mohammed Khadir, Basim Abdulsada Al-Knani, Ahmed F. Hassoon

Baghdad Science Journal

Atmospheric stability is considered one of the most important factors affecting the increase or decrease in wind speed in the atmosphere and thus affecting the wind energy density. Stability conditions are classified into three categories: unstable, stable, and neutral. This study aims to analyze the stability of the atmospheric conditions in Southern Iraq, specifically in the Ali al-Gharbi region, using the Monin-Obukhov length method. Which includes field data for the wind speed at three altitudes (10 m, 30 m, and 50 m) in 2017. The mean daily and seasonal friction velocities were calculated. Wind speed was calculated for different atmospheric …


Preparation And Characterization Of Polymer Pva Nanofibers Doped With Cuo Using The Electrospinning Technique And Their Industrial Applications, Ahmed J. Noori, Iftikhar M. Ali Oct 2025

Preparation And Characterization Of Polymer Pva Nanofibers Doped With Cuo Using The Electrospinning Technique And Their Industrial Applications, Ahmed J. Noori, Iftikhar M. Ali

Baghdad Science Journal

This work examines the production and analysis of electrospun fibers made from pure and CuO-doped polyvinylpyrrolidone (PVA) polymers. These fibers are then applied to glass and p-type silicon wafers. The ideal parameters for electrospinning were a flow rate of 0.5 ml/h, a voltage of 15 kV, and a distance of 16 cm between the collector and the needle. X-ray diffraction investigation determined that the PVA fibers were amorphous, but the CuO-doped samples had a tetragonal phase. Fourier Transform Infrared Spectroscopy (FTIR) was employed to examine the vibrational properties, modes, and network bonding in the 400 to 4000 cm–1 spectral …


Analysis Of Export Competitiveness Of Main Commodities Of North Sulawesi Province, Fahrudin Zain Olilingo, Nur Aini Umar, Ivan Rahmat Santoso Oct 2025

Analysis Of Export Competitiveness Of Main Commodities Of North Sulawesi Province, Fahrudin Zain Olilingo, Nur Aini Umar, Ivan Rahmat Santoso

Jurnal Ekonomi dan Studi Pembangunan

This study describes the competitiveness of the main Commodity Exports of North Sulawesi Province. This research is quantitative in nature, using secondary data obtained from the Central Statistics Agency (BPS) in the form of time series with a period of 5 years (2017-2021); the type of data used is the realization of the export value of the four main commodities of North Sulawesi 2017-2021. This research uses Revealed Comparative Advantage (RCA) analysis. The results of this study indicate (1) commodities identified as the most superior commodities of North Sulawesi, namely the commodity Animal/vegetable fats & oils, commodities fish and shrimp, …


Dynamic Competitiveness Of Indonesian Commodities In Major Export Destination, Hertiana Ikasari Oct 2025

Dynamic Competitiveness Of Indonesian Commodities In Major Export Destination, Hertiana Ikasari

Jurnal Ekonomi dan Studi Pembangunan

This study aims to analyze the export competitiveness and market position of the agricultural, manufacturing, and mining sectors in 10 main export destination countries (China, the United States, Japan, India, Singapore, Malaysia, South Korea, Thailand, the Netherlands, and the Philippines). This study uses secondary data sourced from UN COMTRADE for the period of 2013 – 2018. The data is categorized using a 2-digit Harmonized System (HS) classification. This study uses Revealed Comparative Advantage (RCA) and Export Product Dynamics (EPD) analysis tools. The RCA estimation results show the export competitiveness of Indonesia’s agricultural, industrial, and mining products is still weak and …


Deslenguadas: A Photo Essay On The Performative Remembering Of The Impact Of 1940s Americanization Programs In Northern New Mexico, Yvonne M. Montoya, Fawn-Amber Montoya Oct 2025

Deslenguadas: A Photo Essay On The Performative Remembering Of The Impact Of 1940s Americanization Programs In Northern New Mexico, Yvonne M. Montoya, Fawn-Amber Montoya

International Journal on Responsibility

This photo essay captures the dance performance Deslenguadas by choreographer Yvonne Montoya. Deslenguadas, a dance inspired by a writing of the same name published in Gloria Anzaldúa’s Borderlands/La Frontera: The New Mestiza, is a series of three dances – one duet and two solos. The dances in the series explore the impact the forced loss of the Spanish language had on three generations of one nuevomexicano family from the 1940s to the present day. Through dance, movement, projected animation, and spoken word, the dances explore how each generation internalized racism and shame. At the same time, these generations …


Effect Of Au Nanoparticles Doping On The Structure, Surface Morphology And Optical Properties Of Znago Nanorods, Mohsin Talib Mohammed, Salah M. Saleh Al-Khazali, Bassam A. Salih, Adel H. Omran Alkhayatt Oct 2025

Effect Of Au Nanoparticles Doping On The Structure, Surface Morphology And Optical Properties Of Znago Nanorods, Mohsin Talib Mohammed, Salah M. Saleh Al-Khazali, Bassam A. Salih, Adel H. Omran Alkhayatt

Karbala International Journal of Modern Science

In this work, nanoparticles (NPs) composed of noble elements (Au and Ag) were prepared using a chemical reduction method and then combined with a spray pyrolysis technique for synthesizing ZnAgO and Au-doped ZnAgO nanorods (NRs). The films were produced by adding 2 wt% of Ag NPs and 2, 4, and 6 wt% of Au NPs at 420°C. The results showed that the films have a polycrystalline ZnO (wurtzite) with a hexagonal structure. Also, all films had a preference orientation along the (002) plane. The crystal size increased with increasing Au doping from 64.4 to 65.33 nm. For ZnO doped with …


2025 Celebration Of Scholarship, Creativity, And Engagement, Todd Bruns, Jaime Pedigo, Jennifer Smith, Patty Watson, Heather Wohltman, Amanda Wolf Oct 2025

2025 Celebration Of Scholarship, Creativity, And Engagement, Todd Bruns, Jaime Pedigo, Jennifer Smith, Patty Watson, Heather Wohltman, Amanda Wolf

Programs

Each year, Eastern Illinois University proudly recognizes the outstanding achievements of our faculty in research, creativity, and engagement. This collection of accomplishments reflects the dedication of an engaged faculty committed to excellence and the continual pursuit of knowledge. Many of these successes were made possible through meaningful collaboration with our students, who contribute as co-authors, research assistants, and partners in bringing ideas to life. Some of these professional milestones represent years of effort, demonstrating remarkable persistence and determination. We offer our heartfelt congratulations on this wide range of achievements, which bring distinction to our departments, colleges, and the University as …


The Parthenon, October 22, 2025, Baylee Parsons, Kaitlyn Fleming, Ashton Pack, Nate Harrah, Scott Price, Lilli Ross, Wade Sullivan Oct 2025

The Parthenon, October 22, 2025, Baylee Parsons, Kaitlyn Fleming, Ashton Pack, Nate Harrah, Scott Price, Lilli Ross, Wade Sullivan

The Parthenon

No abstract provided.


In Re: Application Of Financialright Claims Gmbh Oct 2025

In Re: Application Of Financialright Claims Gmbh

2025 Decisions

USDC for the District of Delaware


Daily Eastern News: October 22, 2025, Eastern Illinois University Oct 2025

Daily Eastern News: October 22, 2025, Eastern Illinois University

Daily Eastern News: 2025-2026

No abstract provided.


In Utero Rescue Of Neurological Dysfunction In A Mouse Model Of Wiedemann-Steiner Syndrome., Tinna Reynisdottir, Kimberley J Anderson, Katrin Möller, Stefán Pétursson, Andrew Brinn, Katheryn P Franklin, Juan Ouyang, Asbjorg O Snorradottir, Cathleen Lutz, Aamir Zuberi, Valerie B Deleon, Hans T Bjornsson Oct 2025

In Utero Rescue Of Neurological Dysfunction In A Mouse Model Of Wiedemann-Steiner Syndrome., Tinna Reynisdottir, Kimberley J Anderson, Katrin Möller, Stefán Pétursson, Andrew Brinn, Katheryn P Franklin, Juan Ouyang, Asbjorg O Snorradottir, Cathleen Lutz, Aamir Zuberi, Valerie B Deleon, Hans T Bjornsson

Faculty Research 2025

Wiedemann-Steiner syndrome (WDSTS) is a rare genetic cause of intellectual disability that is primarily caused by heterozygous loss-of-function variants in the gene encoding the histone lysine methyltransferase 2A (KMT2A). Prior studies have shown successful postnatal amelioration of disease phenotypes for Rett, Rubinstein-Taybi, and Kabuki syndromes, which are related Mendelian disorders of the epigenetic machinery. To explore whether the neurological phenotype in WDSTS is treatable in utero, we created a mouse model carrying a loss-of-function variant placed between 2 loxP sites. Kmt2a+/LSL mice demonstrated core features of WDSTS including growth retardation, craniofacial abnormalities, and hypertrichosis as well as hippocampal memory defects. …


Enabling Coercive Drivers With Green Supply Chain Management Practices To Gain Performance Nexus Through External Collaboration And Monitoring, Aamir Rashid, Rizwana Rasheed Oct 2025

Enabling Coercive Drivers With Green Supply Chain Management Practices To Gain Performance Nexus Through External Collaboration And Monitoring, Aamir Rashid, Rizwana Rasheed

Publications and Research

Businesses primarily provide products or services, expand operations, and generate profits. However, they frequently disregard the environmental and economic consequences of their actions as they strive for profitability and growth. Consequently, the main objective of this research was to examine the impact of a multifaceted supply chain function on performance. Data were collected from 415 respondents employed in various manufacturing companies within a developing economy. The hypotheses were evaluated using Structural Equation Modeling (SEM) through Smart PLS. The findings discovered that ten of the thirteen hypotheses tested were supported, while three were not. Coercive drivers were observed to significantly influence …


An End-Of-Life Work-Based Quality Improvement Project To Enhance Posttraumatic Growth In Hospital Employees During Covid-19, Emily E. Calabro, Brittany Zimmerman Oct 2025

An End-Of-Life Work-Based Quality Improvement Project To Enhance Posttraumatic Growth In Hospital Employees During Covid-19, Emily E. Calabro, Brittany Zimmerman

Creating Healthy Work Environments (CHWE)

Hospital employees are at a heightened risk for posttraumatic stress because of the increased exposure to death and dying during the COVID-19 pandemic. We examined whether an EOL program would enhance an employee’s ability to cope with the pandemic stressors and experience existential growth over time.

Detailed abstract attached.


Oxygen Supply Capacity Of The Atlantic Horseshoe Crab,, Marty Sims Oct 2025

Oxygen Supply Capacity Of The Atlantic Horseshoe Crab,, Marty Sims

USF Tampa Graduate Theses and Dissertations

The horseshoe crab, Limulus polyphemus, inhabits shallow bays and estuaries where it encounters variable oxygen levels. Moreover, each year, the biomedical industry harvests hemolymph from hundreds of thousands of horseshoe crabs to use in bacterial contamination testing, yet the effects of bloodletting on their physiology are relatively unknown. This study aims to determine the oxygen supply capacity of Limulus polyphemus in relation to environmental hypoxia and biomedical bloodletting. Study animals were collected from the intertidal waters of Tampa Bay, Florida. Experiments included a control group that did not undergo substantial blood-volume reduction and a treatment group from which 10% of …


Just Cause Protection Under Manager Discrimination, Joseph Pickens, Aaron Sojourner Oct 2025

Just Cause Protection Under Manager Discrimination, Joseph Pickens, Aaron Sojourner

Upjohn Institute Working Papers

“Just cause” policies aim to discourage the arbitrary firing of employees. Recent efforts at passing such laws in the U.S. have been motivated by deterring discrimination. This paper presents a framework to study the effects of just cause when managers engage in taste-based discrimination. The framework generates predictions on whether just cause will ease achievement and retention of stable employment by exploiting the timing of separations around a probationary period. Since probationary periods are a typical feature of protections, the approach is generalizable. We test predictions using New York City’s 2021 just cause law for fast-food employees. Using a synthetic …


Vaccination Against Onchocerca Volvulus Induces Igg-Mediated Protective Immunity Dependent On Neutrophils And Complement, Nathan M. Ryan, Jessica A. Hess, Mohini Nakhale, Annabel A. Ferguson, William Stump, Sara Belko, Rachel Monane, Robert S. Pugliese, Nikolai Petrovsky, Benjamin L. Makepeace, Sean A. Gray, Darrick Carter, Sara Lustigman, David Abraham Oct 2025

Vaccination Against Onchocerca Volvulus Induces Igg-Mediated Protective Immunity Dependent On Neutrophils And Complement, Nathan M. Ryan, Jessica A. Hess, Mohini Nakhale, Annabel A. Ferguson, William Stump, Sara Belko, Rachel Monane, Robert S. Pugliese, Nikolai Petrovsky, Benjamin L. Makepeace, Sean A. Gray, Darrick Carter, Sara Lustigman, David Abraham

Department of Microbiology and Immunology Faculty Papers

Onchocerciasis remains a significant cause of morbidity and economic loss in sub-Saharan Africa. Despite the existence of effective therapeutics, a prophylactic vaccine targeting the etiologic agent, Onchocerca volvulus, is needed to control ongoing disease and transmission. Mice were vaccinated against O. volvulus with a fusion of the recombinant antigens Ov-103 and Ov-RAL-2 (Ov-FUS-1) with Advax-CpG adjuvant. Immunized mice developed protective immunity with the killing of third-stage larvae (L3) within 36 h of challenge infection. IgG from immunized mice passively transferred protective immunity to naïve mice, indicating that antigen-specific IgG mediated parasite elimination. Neutrophils were the most abundant subset of immune …


Rtx-303, An Orally Bioavailable Polθ Polymerase Inhibitor That Potentiates Parp Inhibitors In Brca Mutant Tumors, Gurushankar Chandramouly, William Fried, John Gordon, Douglas Ralph, Channita Keuk, Sangeeta Kumari, Mercy Ramanjulu, William Auerbacher, Leonid Minakhin, Taylor Tredinnick, Bernadette Tiberi, George Morton, Robert Betsch, Kathy Q. Cai, Umeshkumar M Vekariya, Mrityunjay Tyagi, Tomasz Skorski, Sergey Karakashev, Neil Johnson, Wayne E. Childers, Xiaojiang S. Chen, Richard T. Pomerantz Oct 2025

Rtx-303, An Orally Bioavailable Polθ Polymerase Inhibitor That Potentiates Parp Inhibitors In Brca Mutant Tumors, Gurushankar Chandramouly, William Fried, John Gordon, Douglas Ralph, Channita Keuk, Sangeeta Kumari, Mercy Ramanjulu, William Auerbacher, Leonid Minakhin, Taylor Tredinnick, Bernadette Tiberi, George Morton, Robert Betsch, Kathy Q. Cai, Umeshkumar M Vekariya, Mrityunjay Tyagi, Tomasz Skorski, Sergey Karakashev, Neil Johnson, Wayne E. Childers, Xiaojiang S. Chen, Richard T. Pomerantz

Department of Biochemistry and Molecular Biology Faculty Papers

DNA polymerase θ (Polθ) is a polymerase-helicase fusion protein that is synthetically lethal with homologous recombination (HR) factors, such as BRCA1/2, and confers resistance to PARP inhibitors (PARPi) and other genotoxic cancer therapies. Previously developed Polθ polymerase (Polθ-pol) inhibitors (Polθi) exhibited limited pharmacological activity and metabolic stability, warranting the development of a Polθi with improved drug-like properties. Here, we developed RTx-303, a selective allosteric small-molecule Polθ-pol inhibitor that exhibits 5.1 nM IC50, 88% oral bioavailability, and a prolonged half-life along with its equipotent metabolite. X-ray crystallography highlights the development of a solvent-exposed side-chain that is essential for the optimal drug-like …


Redefining Gender And Rural Life In The Pampas: Alessandra Sanguinetti’S The Adventures Of Guille And Belinda Series, Alejandra López-Oliveros Oct 2025

Redefining Gender And Rural Life In The Pampas: Alessandra Sanguinetti’S The Adventures Of Guille And Belinda Series, Alejandra López-Oliveros

Art Inquiries

At the time of Argentina’s independence, the gauchos (nomadic horsemen) had become the symbol of the nation in its purest form. Celebrated as independent, heroic and strong, and usually portrayed as the sole inhabitants of the Pampa, the idealized image of the gaucho has flooded popular culture and art even today, to the detriment of flesh-and-bone wage laborers of all genders. As opposed to this static image, I propose to examine Alessandra Sanguinetti’s photographic series, The Adventures of Guille and Belinda (ongoing since 1999), which focuses on girls and women in the countryside, pointedly highlights their previous absence. By contrasting …


The Second Amendment's Catholic Problem, Jared Danaher Oct 2025

The Second Amendment's Catholic Problem, Jared Danaher

Duke Law Journal

After New York State Rifle & Pistol Association v. Bruen, history is the touchstone of Second Amendment analysis. Thus, this Note explores an understudied part of America's long and complicated history with weapons: Catholic disarmament. By undertaking a detailed historical analysis of three Catholic disarmament measures in the late colonial United States, this Note attempts to determine what the history means for present day firearms law. It concludes that even though courts frequently cite America’s history of Catholic disarmament, they rarely use it in a historically accurate way. Modern courts use Catholic disarmament to justify weapons bans on people …


The Genome Sequence Of The Hemlock Woolly Adelgid, Adelges Tsugae Annand 1924, Bryan M.T. Brunet, Dustin T. Dial, Gaelen R. Burke, Carol D. Von Dohlen, Julia Douglas Freitas, Haley Sanderson, Afiya R. Chida, Samantha J. Jones, Fergal J. Martin, Leanne Haggerty, Stephen W. Scherer, Ioannis Ragoussis, Steven J.M. Jones, Robert G. Foottit, Nathan P. Havill Oct 2025

The Genome Sequence Of The Hemlock Woolly Adelgid, Adelges Tsugae Annand 1924, Bryan M.T. Brunet, Dustin T. Dial, Gaelen R. Burke, Carol D. Von Dohlen, Julia Douglas Freitas, Haley Sanderson, Afiya R. Chida, Samantha J. Jones, Fergal J. Martin, Leanne Haggerty, Stephen W. Scherer, Ioannis Ragoussis, Steven J.M. Jones, Robert G. Foottit, Nathan P. Havill

Biology Faculty Publications

The genome of the hemlock woolly adelgid (Adelges tsugae) is presented in 10 chromosomal pseudomolecules along with 132 unplaced scaffolds for a combined length of 216.56 Mb. The genome is highly contiguous with an N50 of 20.54 Mb and its longest scaffold 37.41 Mb in length. The assembly recovered 97.7% of benchmarked universal single-copy Hemiptera orthologs (BUSCO) with an overall completion score of 98.6%. On the basis of chromosomal synteny with other aphid genomes, the hemlock woolly adelgid’s genome is composed of eight autosomes and two sex (X) chromosomes. Annotation of the assembly identified 11,800 coding genes, 1,930 …